Database : MEDLINE
Search on : Central and Serous and Chorioretinopathy [Words]
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[PMID]: 29523299
[Au] Autor:Venkatesh P; Takkar B; Temkar S
[Ad] Address:Retina and Uvea Services, Dr. R P Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. Electronic address: venkyprao@yahoo.com.
[Ti] Title:Clinical manifestations of pachychoroid may be secondary to pachysclera and increased scleral rigidity.
[So] Source:Med Hypotheses;113:72-73, 2018 Apr.
[Is] ISSN:1532-2777
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Current imaging advancements have led to emergence of pachychoroid as an association of important vision threatening diseases like chronic serous chorioretinopathy and polypoidal choroidal vasculopathy. While the precise relation between thick choroid and such disorder is being investigated, the etiology behind pachychoroid remains elusive. We hypothesize pachychoroid to be a resultant of impeded vascular outflow due to thick sclera and increased scleral rigidity. We discuss our hypothesis in the perspective of other choroidal manifestations of anomalously thick scleral structure.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Process

  2 / 1621 MEDLINE  
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[PMID]: 29353272
[Au] Autor:Lauermann JL; Eter N; Alten F
[Ti] Title:Optical Coherence Tomography Angiography Offers New Insights into Choriocapillaris Perfusion.
[So] Source:Ophthalmologica;239(2-3):74-84, 2018.
[Is] ISSN:1423-0267
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:The choriocapillaris (CC) represents a fundamentally important vascular layer that is subject to physiologic changes with increasing age and that is also associated with a wide range of chorioretinal diseases. So far, information on blood flow in this specific layer has remained limited. With the advent of optical coherence tomography angiography (OCTA), new perspectives and possibilities of CC imaging have begun to evolve. This article shall review the opportunities and challenges of applying OCTA technology to the CC layer and summarize the current clinical efforts in OCTA CC imaging exemplarily in dry age-related macular degeneration and central serous chorioretinopathy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Process
[do] DOI:10.1159/000485261

  3 / 1621 MEDLINE  
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[PMID]: 29517581
[Au] Autor:Hwang S; Kang SW; Kim SJ; Jang JW; Kim KT
[Ad] Address:Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
[Ti] Title:PHOTODYNAMIC THERAPY FOR SYMPTOMATIC SUBFOVEAL RETINAL PIGMENT EPITHELIAL DETACHMENT IN CENTRAL SEROUS CHORIORETINOPATHY: Outcomes and Prognostic Factors.
[So] Source:Retina;, 2018 Mar 05.
[Is] ISSN:1539-2864
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To report the clinical outcomes of reduced-fluence photodynamic therapy (PDT) for symptomatic subfoveal retinal pigment epithelial detachment (RPED) in central serous chorioretinopathy and identify prognostic factors affecting treatment outcome. METHODS: This retrospective interventional study included 35 eyes of 35 patients with serous subfoveal RPED with choroidal hyperpermeability. Cases with evidence of age-related macular degeneration were excluded from the study. Reduced-fluence PDT was applied to each patient. Best-corrected visual acuity, anatomical resolution of RPED, subjective symptom improvement, and complications were analyzed. RESULTS: One month after reduced-fluence PDT, 28 eyes (80.0%) manifested complete resolution of subfoveal RPED. Among the patients whose eyes manifested complete resolution, 19 (67.9%) reported subjective vision improvement. This subjective improvement was significantly associated with the presence of dysmorphopsia at baseline. Logarithm of the minimal angle of resolution visual acuity improved from 0.15 (Snellen equivalent of 20/28) to 0.09 (20/25) between baseline and 3 months after PDT (P = 0.008). Older age and increased RPED height were independent risk factors of poor resolution of RPED after PDT. The mean follow-up period after treatment was 10.4 ± 13.6 months; recurrence of RPED did not occur in any case. CONCLUSION: Subfoveal RPED in central serous chorioretinopathy responded well to reduced-fluence PDT, especially in younger patients with less RPED. Dysmorphopsia, rather than decreased visual acuity, is a main symptomatic presentation in subfoveal RPED.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1097/IAE.0000000000002108

  4 / 1621 MEDLINE  
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[PMID]: 29513616
[Au] Autor:Khochtali S; Ksiaa I; Megzari K; Khairallah M
[Ad] Address:a Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine , University of Monastir , Monastir , Tunisia.
[Ti] Title:Retinal Pigment Epithelium Detachment in Acute Vogt-Koyanagi-Harada Disease: An Unusual Finding at Presentation.
[So] Source:Ocul Immunol Inflamm;:1-4, 2018 Mar 07.
[Is] ISSN:1744-5078
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:PURPOSE: To report the cases of two patients who presented with acute Vogt-Koyanagi-Harada (VKH) disease and associated retinal pigment epithelium detachment (PED). METHODS: 2 case reports. Case 1: A 22-year-old male patient complained of acute bilateral decrease in vision. Initial best corrected visual acuity (BCVA) was 20/63, OU. There was 1+ vitreous cells, OU, exudative retinal detachment (ERD) in the right eye (RE), and a macular deep yellow lesion suggestive of PED in the left eye (LE). Case 2: A 40-year-old female patient presented with bilateral vision blurring. BCVA was 20/40 in the RE and 20/32 in the LE. There was 1+ vitreous cells OU, bilateral optic disc swelling and retinal striae. RESULTS: Multimodal imaging showed features of acute VKH disease with associated PED in the two patients. ERD and PED resolved under oral prednisone and cyclosporine in both cases. CONCLUSION: PED may rarely occur in acute VKH disease at presentation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:Publisher
[do] DOI:10.1080/09273948.2018.1433304

  5 / 1621 MEDLINE  
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[PMID]: 29368595
[Au] Autor:Park J; Lee M
[Ad] Address:Department of Ophthalmology, College of Medicine, Dankook University, 119, Dandae-ro, Dnognam-gu, Cheonan-si, Chungchungnam-do, Republic of Korea.
[Ti] Title:Short-term effects and safety of an acute increase of intraocular pressure after intravitreal bevacizumab injection on corneal endothelial cells.
[So] Source:BMC Ophthalmol;18(1):17, 2018 Jan 25.
[Is] ISSN:1471-2415
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: The purpose of this study is to evaluate short-term effects and safety of an acute increase of intraocular pressure (IOP) after single-dose intravitreal bevacizumab injection on corneal endothelial cells and central corneal thickness. METHODS: Forty-two patients who underwent intravitreal injection of 2.5 mg/0.1 ml bevacizumab because of central serous chorioretinopathy or diabetic macular edema were included in this study. The changes of IOP, corneal endothelial cells, and corneal thickness at baseline, 2 min, 5 min, and 30 min after injection were analyzed prospectively with a specular microscope. RESULTS: In all patients, the mean IOPs at baseline, 2 min, 5 min, and 30 min after injection were 11.48 ± 2.22 mmHg, 49.71 ± 10.73 mmHg, 37.64 ± 11.68 mmHg, and 14.88 ± 4.77 mmHg, respectively. These changes were significant (p < 0.01). In only one eye, IOP did not decrease to ≤30 mmHg even at 30 min after injection. According to changes in IOP with time, the coefficient of variation of the corneal endothelium significantly increased (p = 0.03), but cell density, hexagonality of the corneal endothelium, and central corneal thickness did not change (p = 0.79, 0.21, and 0.08, prospectively). One week after injection, there was no sign of inflammation or any other complications in all 42 eyes. CONCLUSIONS: After intravitreal injection, IOP rapidly increases, then decreases to the normal range in most eyes 30 min after injection and it is tolerable to corneal endothelium. TRIAL REGISTRATION: Clinical Research Information Service (CRiS), Republic of Korea, KCT0002645 . Retrospectively registered 9 January 2018.
[Mh] MeSH terms primary: Bevacizumab/adverse effects
Endothelium, Corneal/drug effects
Intraocular Pressure/drug effects
Macular Degeneration/drug therapy
Macular Edema/drug therapy
Ocular Hypertension/chemically induced
[Mh] MeSH terms secundary: Acute Disease
Angiogenesis Inhibitors/administration & dosage
Angiogenesis Inhibitors/adverse effects
Bevacizumab/administration & dosage
Endothelium, Corneal/pathology
Female
Follow-Up Studies
Humans
Incidence
Intraocular Pressure/physiology
Intravitreal Injections
Macular Degeneration/diagnosis
Macular Edema/diagnosis
Male
Middle Aged
Ocular Hypertension/epidemiology
Ocular Hypertension/physiopathology
Prospective Studies
Republic of Korea/epidemiology
Time Factors
Vascular Endothelial Growth Factor A/antagonists & inhibitors
[Pt] Publication type:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Name of substance:0 (Angiogenesis Inhibitors); 0 (Vascular Endothelial Growth Factor A); 2S9ZZM9Q9V (Bevacizumab)
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:IM
[Da] Date of entry for processing:180126
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0682-9

  6 / 1621 MEDLINE  
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[PMID]: 29289690
[Au] Autor:Tripathy K
[Ad] Address:ICARE Eye Hospital & Postgraduate Institute, Noida, Uttar Pradesh, India.
[Ti] Title:Central serous chorioretinopathy following medial transposition of split lateral rectus muscle for complete oculomotor nerve palsy.
[So] Source:J AAPOS;22(1):83, 2018 Feb.
[Is] ISSN:1528-3933
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1801
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[St] Status:In-Data-Review

  7 / 1621 MEDLINE  
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[PMID]: 29474303
[Au] Autor:Wu CY; Riangwiwat T; Rattanawong P; Nesmith BLW; Deobhakta A
[Ad] Address:Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York.
[Ti] Title:ASSOCIATION OF OBSTRUCTIVE SLEEP APNEA WITH CENTRAL SEROUS CHORIORETINOPATHY AND CHOROIDAL THICKNESS: A Systematic Review and Meta-Analysis.
[So] Source:Retina;, 2018 Feb 22.
[Is] ISSN:1539-2864
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: Obstructive sleep apnea (OSA) has been associated with an array of ocular disorders. This systematic review aims to investigate the association of OSA with central serous chorioretinopathy (CSCR) and subfoveal choroidal thickness changes on enhanced depth imaging optical coherence tomography. METHODS: Systematic review and meta-analysis of all articles published up to November 2017 examining rate of OSA in patients with CSCR versus controls or examining subfoveal choroidal thickness measurements on enhanced depth imaging optical coherence tomography in patients with OSA versus controls. Pooled odds ratios and weighted mean difference with 95% confidence intervals (CIs) were calculated. RESULTS: For the CSCR/OSA analysis, 7,238 patients (1,479 with CSCR and 5,759 controls) from 6 studies were eligible. For the choroidal thickness/OSA analysis, 778 eyes of 778 patients (514 with OSA and 264 controls) from 9 studies were eligible. Patients with CSCR had a 1.56 increased odds of having OSA than controls (odds ratio, 1.56; 95% CI, 1.16-2.10). There was no statistically significant difference in choroidal thickness between mild OSA subjects and controls (weighted mean difference = -3.17; 95% CI, -19.10 to 12.76). Patients with moderate OSA (weighted mean difference = -24.14; 95% CI, -42.16 to -6.12) and severe OSA (weighted mean difference = -51.19; 95% CI, -99.30 to -3.08) had thinner choroidal thickness measurements than controls. CONCLUSION: In summary, our results suggest that patients with CSCR are more likely to have OSA, and that moderate/severe OSA is associated with smaller subfoveal choroidal measurements on enhanced depth imaging optical coherence tomography.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180223
[Lr] Last revision date:180223
[St] Status:Publisher
[do] DOI:10.1097/IAE.0000000000002117

  8 / 1621 MEDLINE  
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[PMID]: 29470299
[Au] Autor:Saito W; Hashimoto Y; Hirooka K; Ishida S
[Ad] Address:Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
[Ti] Title:CHOROIDAL THICKNESS CHANGES IN A PATIENT DIAGNOSED WITH CENTRAL SEROUS CHORIORETINOPATHY DURING FOLLOW-UP FOR PACHYCHOROID PIGMENT EPITHELIOPATHY.
[So] Source:Retin Cases Brief Rep;, 2018 Feb 21.
[Is] ISSN:1937-1578
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To evaluate chronological changes in choroidal thickness in a patient with pachychoroid pigment epitheliopathy (PPE) who was later diagnosed with central serous chorioretinopathy (CSC) during follow-up. METHODS: Case report. RESULTS: A 43-year-old man complained of metamorphopsia in the left eye. Funduscopy showed several punctate white subretinal lesions at the macula, but no macular serous retinal detachment in the left eye. Retinal pigment epithelium abnormality without serous retinal detachment at the macula on optical coherence tomography and choroidal vascular hyperpermeability on indocyanine green angiography suggested PPE in the left eye. Macular lesions disappeared with no treatment. Twenty-five months after the initial visit, PPE recurred in the left eye. Thirty-five months after the initial visit, the patient was diagnosed with CSC in the left eye. Macular serous retinal detachment spontaneously resolved. In the eye with PPE and CSC, the choroid was consistently thicker than that in the fellow eye during follow-up. The choroid became thicker during the alternate onsets of PPE and CSC and thinner after regression of these diseases. CONCLUSION: These results suggest that PPE and CSC overlap clinically and choroidal thickening is involved in the pathogenesis of both diseases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:Publisher
[do] DOI:10.1097/ICB.0000000000000728

  9 / 1621 MEDLINE  
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[PMID]: 29380797
[Au] Autor:Panigrahi PK; Minj A; Satapathy J
[Ad] Address:Department of Ophthalmology, Institute of Medical Sciences and SUM Hospital, SOA University, Bhubaneswar, Odisha, India.
[Ti] Title:Torpedo maculopathy with multifocal central serous chorioretinopathy: A rare case report.
[So] Source:Indian J Ophthalmol;66(2):330-331, 2018 Feb.
[Is] ISSN:1998-3689
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:We present a very rare case of torpedo maculopathy (TM) with multifocal central serous chorioretinopathy. A 26-year-old male presented with painless loss of vision in the right eye of 2 months duration. Clinical examination showed a torpedo-shaped lesion temporal to fovea and subretinal fluid in foveal center. Fluorescein angiography showed multifocal leaks. Optical coherence tomography showed an optically clear space/neurosensory detachment at the site of lesion. Patient underwent focal laser to the leaks. TM is a rare congenital disorder detected accidentally during routine fundus examination. It is usually unilateral and does not affect vision.
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1801
[Cu] Class update date: 180223
[Lr] Last revision date:180223
[St] Status:In-Data-Review
[do] DOI:10.4103/ijo.IJO_812_17

  10 / 1621 MEDLINE  
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[PMID]: 29420438
[Au] Autor:Lim HB; Sung JY; Ahn SI; Jo YJ; Kim JY
[Ad] Address:Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
[Ti] Title:Retinal Nerve Fiber Layer Thickness in Various Retinal Diseases.
[So] Source:Optom Vis Sci;95(3):247-255, 2018 Mar.
[Is] ISSN:1538-9235
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:SIGNIFICANCE: Peripapillary retinal nerve fiber layer (RNFL) thickness measurements may be influenced by the range and severity of lesions that are observed distinctively in each retinal disease. PURPOSE: We investigated the effects of various macular (central serous chorioretinopathy, macular hole, epiretinal membrane, wet age-related macular degeneration) and retinal vascular (branch retinal vein occlusion, central retinal vein occlusion, diabetic macular edema) diseases on peripapillary RNFL thickness measurements using spectral-domain optical coherence tomography. METHODS: Six hundred thirty-one eyes from 464 patients with various retinal diseases and 167 controls of similar age were included in this retrospective study. Using spectral-domain optical coherence tomography, we measured the thickness of the macula and the RNFL in both various retinal disease eyes and normal control eyes. Four sectorial and average RNFL thicknesses were compared between each disease and age-matched control eyes. The macular thicknesses were also compared. RESULTS: In the macular disease group, superior (P = .033) and temporal (P = .024) quadrant RNFL thicknesses of central serous chorioretinopathy and temporal (P < .001) quadrant RNFL thicknesses of epiretinal membrane were greater than the age-matched control eyes. No RNFL measurements in macular hole or wet age-related macular degeneration differed significantly from the controls. In the retinal vascular disease group, all sectorial and average RNFL thicknesses of diabetic macular edema and central retinal vein occlusion were greater than those of the controls (all P < .05). In branch retinal vein occlusion, superior (P = .012) and temporal (P < .001) quadrant RNFL thicknesses were greater than those of the controls. CONCLUSIONS: Peripapillary RNFL thickness measurements may be influenced by the range and severity of lesions that are observed distinctively in each retinal disease. It also appeared that macular disease had a local effect on RNFL thickness, whereas retinal vascular disease had a diffuse effect on RNFL thickness.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180221
[Lr] Last revision date:180221
[St] Status:In-Data-Review
[do] DOI:10.1097/OPX.0000000000001181


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