Database : MEDLINE
Search on : Cholelithiasis [Words]
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[PMID]: 29524341
[Au] Autor:Tan T; Zhang J; Xu X; Huang WP; Luo Y
[Ad] Address:The National Pharmaceutical Engineering Center (NPEC) for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Jiangxi, Nanchang, China.
[Ti] Title:Geographical discrimination of Glechomae Herba based on fifteen phenolic constituents determined by LC-MS/MS method combined with chemometric methods.
[So] Source:Biomed Chromatogr;, 2018 Mar 10.
[Is] ISSN:1099-0801
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Glechomae Herba (GH) is rich in bioactive phenolic constituents, which is widely used for treatment of cholelithiasis, urolithiasis and dropsy. The simultaneous determination of phenolic constituents in GH from different geographical origins is significant for authentication and quality control purposes. In this study, we developed a strategy integrating targeted analysis and chemometric methods for quality evaluation and discrimination of GH from different geographical origins. Firstly, an accurate and reliable liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for simultaneous quantification of fifteen phenolic constituents in GH from different geographical origins. The established method was well validated in terms of desirable specificity, linearity, precision and accuracy. Secondly, the quantitative data were subjected to the principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA). Thirdly, a heatmap visualization was employed for clarifying the distribution of fifteen phenolic compounds in GH from different geographical origins. These results indicated that GH samples from Shandong province have obviously different with those from other provinces in the content of bioactive phenolic constituents. Collectively, the proposed platform might be well-acceptable tool for quality evaluation and discrimination of GH from different geographical origins, providing promising perspectives in tracking the formulation processes of TCMs products.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1002/bmc.4239

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[PMID]: 29519664
[Au] Autor:Juo YY; Khrucharoen U; Chen Y; Sanaiha Y; Benharash P; Dutson E
[Ad] Address:Center for Advanced Surgical and Interventional Technology (CASIT), University of California at Los Angeles, Los Angeles, California; Department of Surgery, The George Washington University, Washington, D.C.
[Ti] Title:Cost analysis and risk factors for interval cholecystectomy after bariatric surgery: a national study.
[So] Source:Surg Obes Relat Dis;14(3):368-374, 2018 Mar.
[Is] ISSN:1878-7533
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Besides rate and extent of weight loss, little is known regarding demographic factors predicting interval cholecystectomy (IC) after bariatric surgery and its incremental costs. OBJECTIVES: We aim to identify risk factors predicting IC after bariatric surgery and quantify its associated costs. SETTING: Nationally representative sampling of acute care hospitals across the United States. METHODS: A retrospective cohort study was performed using the National Readmission Database 2010 to 2014. Cox proportional hazard analyses were used to identify risk factors for IC. Linear regression models were constructed to examine associations between cholecystectomy timing and cumulative hospitalization costs. RESULTS: An estimated national total of 553,658 patients received bariatric surgery during the study period. Of these, 3.3% received concomitant cholecystectomy (CC). After adjusting for bariatric procedure type, age, sex, complication, and length of stay, CC was independently associated with a US$1589 increase in hospitalization cost (95% confidence interval US$1021-2158, P<.01). Of patients that received no CC, only .6% underwent IC during the up to 1-year follow-up. Age<35 (P<.01), female sex (P<.01), and high preoperative body mass index (P = .03) were all risk factors for IC. IC was independently associated with a US$1499 higher cumulative hospitalization cost than CC (P<.01, 95% confidence interval US$844-2154). CONCLUSIONS: Despite the higher absolute cost of IC, its low incidence does not financially justify a routine prophylactic CC approach. In addition, no significant reduction in cholecystectomy-related complications was achieved by performing CC. An individualized approach taking identified risk factors for IC into consideration is recommended when deciding whether to perform prophylactic CC.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review

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[PMID]: 29513172
[Au] Autor:Sasabuchi Y; Yasunaga H; Matsui H; Lefor AK; Fushimi K; Sanui M
[Ti] Title:Epidural analgesia is infrequently used in patients with acute pancreatitis : a retrospective cohort study.
[So] Source:Acta Gastroenterol Belg;80(3):381-384, 2017 Jul-Sep.
[Is] ISSN:1784-3227
[Cp] Country of publication:Belgium
[La] Language:eng
[Ab] Abstract:BACKGROUNDS AND AIMS: Epidural analgesia is an option for pain control in patients with acute pancreatitis. The aim of this study is to describe characteristics, morbidity and mortality of patients with acute pancreatitis treated with epidural analgesia. PATIENTS AND METHODS: n on patients hospitalized with acute pancreatitis between July 2010 and March 2013. A total of 44,146 patients discharged from acute care hospitals were included in this retrospective cohort study. The patient background, timing and duration of epidural analgesia, complications (epidural hematoma or abscess), surgery (for cholelithiasis / cholecystitis or complications) and mortality were verified. RESULTS: Epidural analgesia was used in 307 patients (0.70 %). The mean age was 64.0 years (standard deviation, 15.4 years) and 116 (37.8%) of the patients were female. The median duration of epidural analgesia was four days (interquartile range, 3-5 days). No patient underwent surgery for epidural hematoma or abscess. Six (2.0%) patients died during hospitalization. Most likely causes of death were pulmonary embolism, multiple organ failure, sepsis, and methicillin-resistant staphylococcus aureus enterocolitis. The responsible physician for 250 of the patients (81.4%) was a gastroenterological surgeon. Epidural analgesia was started on the day of surgery in 278 (90.6%) patients. CONCLUSION: Epidural analgesia is rarely used in patients with acute pancreatitis. None of the patients included in the study required surgery for epidural hematoma or abscess. Further research to evaluate the efficacy and safety of epidural analgesia in patients with acute pancreatitis is warranted.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Data-Review

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[PMID]: 29506881
[Au] Autor:de Santibañes M; Glinka J; Pelegrini P; Alvarez FA; Elizondo C; Giunta D; Barcan L; Simoncini L; Dominguez NC; Ardiles V; Mazza O; Claria RS; de Santibañes E; Pekolj J
[Ad] Address:Department of General Surgery, Hospital Italiano de Buenos Aires, Buenos,Aires, Argentina. Electronic address: martin.desantibanes@hospitalitaliano.org.ar.
[Ti] Title:Extended antibiotic therapy versus placebo after laparoscopic cholecystectomy for mild and moderate acute calculous cholecystitis: A randomized double-blind clinical trial.
[So] Source:Surgery;, 2018 Mar 02.
[Is] ISSN:1532-7361
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Acute calculous cholecystitis (ACC) is the most common complication of cholelithiasis. Laparoscopic cholecystectomy (LC) is the gold standard treatment in mild and moderate forms. Currently there is consensus for the use of antibiotics in the preoperative phase of ACC. However, the need for antibiotic therapy after surgery remains undefined with a low level of scientific evidence. METHODS: The CHART (Cholecystectomy Antibiotic Randomised Trial) study is a single-center, prospective, double blind, and randomized trial. Patients with mild to moderate ACC operated by LC were randomly assigned to receive antibiotic (amoxicillin/clavulanic acid) or placebo treatment for 5 consecutive days. The primary endpoint was postoperative infectious complications. Secondary endpoints were as follows: (1) duration of hospital stay, (2) readmissions, (3) reintervention, and (4) overall mortality. RESULTS: In the per-protocol analysis, 6 of 104 patients (5.8%) in the placebo arm and 6 of 91 patients (6.6%) in the antibiotic arm developed postoperative infectious complications (absolute difference 0.82 (95% confidence interval, -5.96 to 7.61, P = .81). The median hospital stay was 3 days. There was no mortality. There were no differences regarding readmissions and reoperations between the 2 groups. CONCLUSION: Although this trial failed to show noninferiority of postoperative placebo compared to antibiotic treatment after LC for mild and moderate ACC within a noninferiority margin of 5%, the use of antibiotics in the postoperative period does not seem justified, because it was not associated with a decrease in the incidence of infectious and other types of morbidity in the present study.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:Publisher

  5 / 25654 MEDLINE  
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[PMID]: 29501782
[Au] Autor:Peponis T; Eskesen TG; Mesar T; Saillant N; Kaafarani HM; Yeh DD; Fagenholz PJ; de Moya MA; King DR; Velmahos GC
[Ad] Address:Department of Surgery, Massachusetts General Hospital, Boston, MA.
[Ti] Title:Bile Spillage as a Risk Factor for Surgical Site Infection after Laparoscopic Cholecystectomy: A Prospective Study of 1,001 Patients.
[So] Source:J Am Coll Surg;, 2018 Mar 01.
[Is] ISSN:1879-1190
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Bile spillage (BS) occurs frequently during laparoscopic cholecystectomy, yet its impact on postoperative outcomes remains unknown. We hypothesized that BS increases the risk of surgical site infections (SSI) after laparoscopic cholecystectomy. STUDY DESIGN: Patients older than 18, who were admitted to an academic hospital for a laparoscopic (or laparoscopic converted to open) cholecystectomy from 05/2010 to 03/2017, were prospectively included. Open cholecystectomies were excluded. Patients were assessed clinically during hospitalization and two to four weeks after discharge. We compared those who had BS during the operation to those who did not. Our primary endpoint was the rate of SSI. Stepwise logistic regression was used to identify independent predictors of SSI. RESULTS: Of 1,001 patients, 49.9% underwent laparoscopic cholecystectomy for acute cholecystitis, 20.9% for symptomatic cholelithiasis or biliary colic, 12.8% for gallstone pancreatitis, and 16.4% for other indications. Bile was spilled intra-operatively in 591 patients (59.0%), with hydrops noted in 10.5% and empyema in 14.6% of them. In 202 (20.2%) patients BS was accompanied by stone spillage. Patients with BS were older (median age of 52 versus 42, p<0.001) and more frequently male (44.8% versus 27.8%, p<0.001). Conversion to open was more likely in operations with BS (13.0% versus 4.4%, p<0.001). BS was associated with a higher SSI rate (7.1% versus 2.4%, p=0.001) and longer hospital stay (median of 3 versus 2 days, p<0.001). In the multivariable analysis, BS, conversion to open, and ASA>2 were independent predictors of SSI (odds ratio: 2.29, 2.46, and 2.1 respectively, p<0.05). CONCLUSION: BS is associated with SSI and surgeons should take extra caution to avoid it during laparoscopic cholecystectomy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180304
[Lr] Last revision date:180304
[St] Status:Publisher

  6 / 25654 MEDLINE  
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[PMID]: 29465584
[Au] Autor:Fan X; He L; Khadaroo PA; Zhou D; Lin H
[Ad] Address:Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine.
[Ti] Title:Duplication of the extrahepatic bile duct: A case report and review of the literatures.
[So] Source:Medicine (Baltimore);97(8):e9953, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Duplication of the extrahepatic bile duct is an extremely rare congenital anomaly of the biliary system. PATIENT CONCERNS: A 44-year-old woman presented with a history of continuous upper abdominal pain and vomiting. DIAGNOSES: Magnetic resonance cholangiopancreatography (MRCP) disclosed diffuse dilatation of the intrahepatic and extrahepatic bile ducts. Endoscopic retrograde cholangiopancreatography (ERCP) showed the presence of two extrahepatic bile ducts with calculus at the distal end of the CBD. INTERVENTIONS: Laparoscopic cholecystectomy (LC) was performed after an ERCP. Choledochoscopy, performed during the operation, showed duplicated common bile duct and the cystic duct was seen opening at the right side of the extrahepatic duct. OUTCOMES: The patient was doing well after 6 months of follow-up. LESSONS: We reported a case of a double common duct with choledocholithiasis and gallstone. This rare anomaly may lead to cholangitis, common bile duct injury during surgery, malignancy occurrence, and should be treated with extreme care.
[Mh] MeSH terms primary: Bile Duct Diseases/congenital
Bile Ducts, Extrahepatic/abnormalities
Common Bile Duct/abnormalities
[Mh] MeSH terms secundary: Adult
Cholangiopancreatography, Endoscopic Retrograde
Cholangiopancreatography, Magnetic Resonance
Cholecystectomy, Laparoscopic
Choledocholithiasis/congenital
Female
Gallstones/congenital
Humans
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009953

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[PMID]: 29470901
[Au] Autor:Sumin SA; Avdeeva NN; Bystrova NA; Konoplya AL; Komissinskaya LS
[Ti] Title:[STRUCTURAL AND FUNCTIONAL PROPERTIES OF ERYTHROCYTES WHEN USING VARIOUS METHODS OF MULTICOMPONENT GENERAL ANESTHESIA AT LAPAROSCOPIC HOLETSISTEKTOMY AT PATIENTS WITH CHOLELITHIASIS.]
[So] Source:Anesteziol Reanimatol;61(4):296-300, 2016 Jul.
[Is] ISSN:0201-7563
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:At patients with the verfied diagnosis have a cholelithiasis, transferred a laparoscopic holetsistektomy against the combined general anesthesia with muscle relaxants and artificial lung ventilation with use ofvarious anesthetics, the intraerythrocyte intensifi- cation of processes of peroxidation of lipids is established, and in a membrane of erythrocytes essential change of the contents and a ratio of the proteins and lipids responsible for structure, stabilization of a membrane and function of erythrocytes is revealed. Application of a sevoflurane, in comparison with propofol and, especially, a halothane, to a lesser extent influences structurally functional properties of erythrocytes that demands profile development ofpharmacological correction of the revealed violations.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:In-Process

  8 / 25654 MEDLINE  
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[PMID]: 29224843
[Au] Autor:Subirana Magdaleno H; Caro Tarragó A; Olona Casas C; Díaz Padillo A; Franco Chacón M; Vadillo Bargalló J; Saludes Serra J; Jorba Martín R
[Ad] Address:Servei de Cirurgia General i de l'Aparell Digestiu, Hospital Universitari Joan XXIII, Tarragona, España. Electronic address: Helena.subirana@gmail.com.
[Ti] Title:Valoración del impacto de la educación preoperatoria en la colecistectomía laparoscópica ambulatoria. Ensayo prospectivo aleatorizado doble ciego. Evaluation of the impact of preoperative education in ambulatory laparoscopic cholecystectomy. A prospective, double-blind randomized trial.
[So] Source:Cir Esp;96(2):88-95, 2018 Feb.
[Is] ISSN:1578-147X
[Cp] Country of publication:Spain
[La] Language:eng; spa
[Ab] Abstract:INTRODUCTION: Outpatient laparoscopic cholecystectomy is a safe procedure and provides a better use of health resources and perceived satisfaction without affecting quality of care. Preoperative education has shown less postoperative stress, pain and nausea in some interventions. The principal objective of this study is to assess the impact of preoperative education on postoperative pain in patients undergoing ambulatory laparoscopic cholecystectomy. Secondary objectives were: to evaluate presence of nausea, morbidity, hospital admissions, readmissions rate, quality of life and satisfaction. METHODS: Prospective, randomized, and double blind study. Between April 2014 and May 2016, 62 patients underwent outpatient laparoscopic cholecystectomy. INCLUSION CRITERIA: ASA I-II, age 18-75, outpatient surgery criteria, abdominal ultrasonography with cholelithiasis. Patient randomization in two groups, group A: intensified preoperative education and group B: control. RESULTS: Sixty-two patients included, 44 women (71%), 18 men (29%), mean age 46,8 years (20-69). Mean BMI 27,5. Outpatient rate 92%. Five cases required admission, two due to nausea. Pain scores obtained using a VAS was at 24-hour, 2,9 in group A and 2,7 in group B. There were no severe complications or readmissions. Results of satisfaction and quality of life scores were similar for both groups. CONCLUSIONS: We did not find differences due to intensive preoperative education. However, we think that a correct information protocol should be integrated into the patient's preoperative preparation. Registered in ISRCTN number ISRCTN83787412.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180225
[Lr] Last revision date:180225
[St] Status:In-Process

  9 / 25654 MEDLINE  
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[PMID]: 29390530
[Au] Autor:Raasck K; Khoury J; Aoude A; Abduljabbar F; Jarzem P
[Ti] Title:Nonsurgical management of an extensive spontaneous spinal epidural hematoma causing quadriplegia and respiratory distress in a choledocholithiasis patient: A case report.
[So] Source:Medicine (Baltimore);96(51):e9368, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Spontaneous spinal epidural hematoma (SSEH) manifests from blood accumulating in the epidural space, compressing the spinal cord, and leading to acute neurological deficits. The disease's cloudy etiology and rarity contribute to dangerously suboptimal therapeutic principles. These neural deficits can be permanent, even fatal, if the SSEH is not treated in a timely and appropriate manner. Standard therapy is decompressive laminectomy, though nonsurgical management is a viable course of action for patients who meet a criterion that is continuously being refined. PATIENT CONCERNS: A 76-year-old woman on warfarin for a past pulmonary embolism presented to the emergency room with jaundice, myalgia, hematuria, neck pain, and an International Normalized Ratio (INR) of 14. Upon admission, she rapidly developed quadriplegia and respiratory distress that necessitated intubation. DIAGNOSES: T2-weighted magnetic resonance imaging (MRI) revealed an epidural space-occupying hyperintensity from C2 to S5 consistent with a spinal epidural hematoma. An incidental finding of dilated intrahepatic and common bile ducts prompted an endoscopic retrograde cholangiopancreatography, which demonstrated choledocholithiasis. INTERVENTIONS: The patient's INR was normalized with Vitamin K and Beriplex. Upon transfer to the surgical spine team for assessment of a possible intervention, the patient began to demonstrate recovery of neural functions. The ensuing sustained motor improvement motivated the team's preference for close neurologic monitoring and continued medical therapy over surgery. Thirteen hours after the onset of her symptoms, the patient was extubated. A sphincterotomy was later performed, removing 81 common bile duct stones. OUTCOMES: MRI demonstrated complete resorption of the SSEH and the patient maintained full neurological function at final follow-up. LESSONS: Nonsurgical management of SSEH should be considered in the context of early and sustained recovery. Severe initial neural deficit does not necessitate surgical decompression. Choledocholithiasis and subsequent Vitamin K deficiency, particularly when coupled with anticoagulant use, can increase INR and is a novel proposed risk factor for SSEH. Furthermore, coagulopathies should be medically corrected before surgical intervention within a given timeframe, as spontaneous recovery may manifest. This should be favored over surgery in patients demonstrating early and sustained recovery, as nonsurgical management is 25% more effective in achieving full recovery.
[Mh] MeSH terms primary: Choledocholithiasis/surgery
Hematoma, Epidural, Spinal/diagnostic imaging
Quadriplegia/rehabilitation
Respiratory Insufficiency/therapy
Warfarin/adverse effects
[Mh] MeSH terms secundary: Aged
Cholangiopancreatography, Endoscopic Retrograde/methods
Choledocholithiasis/complications
Choledocholithiasis/diagnostic imaging
Conservative Treatment
Emergency Service, Hospital
Female
Follow-Up Studies
Hematoma, Epidural, Spinal/complications
Hematoma, Epidural, Spinal/etiology
Humans
International Normalized Ratio
Intubation, Intratracheal
Pulmonary Embolism/diagnosis
Pulmonary Embolism/drug therapy
Quadriplegia/diagnosis
Quadriplegia/etiology
Recovery of Function
Respiratory Insufficiency/diagnosis
Risk Assessment
Severity of Illness Index
Warfarin/therapeutic use
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:5Q7ZVV76EI (Warfarin)
[Em] Entry month:1802
[Cu] Class update date: 180219
[Lr] Last revision date:180219
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009368

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[PMID]: 29454428
[Au] Autor:Kurtcehajic A; Alibegovic E; Hujdurovic A; Vele E; Kurtcehajic D
[Ad] Address:Department of Internal Medicine, Medical Center "Plava Poliklinika", Tuzla, Bosnia and Herzegovina.
[Ti] Title:Role of Cholelithiasis in Development of Portal Vein Aneurysm.
[So] Source:Am J Med;131(3):e119, 2018 Mar.
[Is] ISSN:1555-7162
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1802
[Cu] Class update date: 180218
[Lr] Last revision date:180218
[St] Status:In-Data-Review


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