Database : MEDLINE
Search on : Chondrocalcinosis [Words]
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[PMID]: 29471516
[Au] Autor:Besselink NJ; van der Meijde P; Rensen WHJ; Meijer PBL; Marijnissen ACA; van Laar JM; Lafeber FPJG; Jacobs JWG
[Ad] Address:Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
[Ti] Title:Optical spectral transmission to assess inflammation in hand and wrist joints of rheumatoid arthritis patients.
[So] Source:Rheumatology (Oxford);, 2018 Feb 19.
[Is] ISSN:1462-0332
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Objective: To develop an optical spectral transmission (OST) model to measure joint inflammation, and thus disease activity, as well as to evaluate (patho-)physiological findings that could lead to misclassification of inflammation. Methods: Forty-six RA patients were included in this cross-sectional study, where US scores, duplicate OST measurements and 28-joint DAS (DAS28) were acquired. With US as a reference standard, the diagnostic performance of OST in detecting inflammation at the joint level was evaluated using receiver operating characteristic (ROC) curve analyses. At the patient level, correlations with US were analysed for DAS28 and OST, and at joint level for OST and tender and swollen joint counts (TJC and SJC, respectively). Joint pathology potentially influencing misclassification by OST [erosions, osteophytes, tendon (sheath) inflammation (ab)normal vasculature and chondrocalcinosis] was evaluated for significance in a multivariate nominal logistic regression model. Results: Diagnostic performance of OST was good for MCP [area under the ROC curve (AUC-ROC) 0.88], PIP (AUC-ROC 0.83) and wrist (AUC-ROC 0.74) joints and for all joints together (AUC-ROC 0.85). At the patient level, DAS28 correlated very poorly (ρ = 0.06) and OST moderately (ρ = 0.54) with US. At the joint level, US correlation with OST was strong (ρ = 0.64), with SJC it was weak (ρ = 0.30) and with TJC it was very weak (ρ = -0.02). Misclassification of inflammation by OST was relatively rare (17%). Dorsal erosions [odds ratio (OR) 4.0], osteophytes (OR 2.1) and extensor tendinitis (OR 4.6) increased the risk of underestimating inflammation of MCP and PIP joints and osteophytes (OR 3.0) also increased the risk of overestimating inflammation. Conclusion: OST is a sensitive, specific and objective technique to assess joints inflammation of the hands and wrists of RA patients, even though bone and tendon pathology increases the risk of misclassification.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:Publisher
[do] DOI:10.1093/rheumatology/kex531

  2 / 2131 MEDLINE  
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[PMID]: 29252740
[Au] Autor:Krochak R; Culbertson MD; Vigorita V; Goodman H
[Ad] Address:Departments of Orthopaedic Surgery (R.K., M.D.C., and H.G.) and Pathology (V.V.), Maimonides Medical Center, Brooklyn, New York.
[Ti] Title:Atypical Tumoral Presentation of Calcium Pyrophosphate Deposition Disease: A Case Report.
[So] Source:JBJS Case Connect;6(4):e86, 2016 Oct-Dec.
[Is] ISSN:2160-3251
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:CASE: A 55-year-old man presented with a history of forefoot pain and swelling. Radiographs revealed a mass with internal calcifications and osseous erosion of the fifth metatarsophalangeal bone. The mass was isointense to muscle on T1-weighted magnetic resonance imaging (MRI) and hyperintense on T2-weighted MRI. A biopsy was performed, and intraoperatively, the lesion appeared as chalky white material, which under polarized light microscopy was composed of weakly positively birefringent rhomboid crystals, leading to a diagnosis of tophaceous pseudogout. CONCLUSION: Tophaceus pseudogout should be included in the differential diagnosis of neoplastic-appearing lesions in the foot, and polarized light microscopy should be used when examining biopsy specimens.
[Mh] MeSH terms primary: Chondrocalcinosis/diagnosis
Forefoot, Human/diagnostic imaging
[Mh] MeSH terms secundary: Chondrocalcinosis/pathology
Chondrocalcinosis/surgery
Diagnosis, Differential
Forefoot, Human/surgery
Humans
Male
Middle Aged
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[Js] Journal subset:IM
[Da] Date of entry for processing:171219
[St] Status:MEDLINE
[do] DOI:10.2106/JBJS.CC.16.00050

  3 / 2131 MEDLINE  
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[PMID]: 29338885
[Au] Autor:Sabchyshyn V; Konon I; Ryan LM; Rosenthal AK
[Ad] Address:Division of Rheumatology, Department of Medicine, Medical College of Wisconsin, FOEB, 4th Floor, 9200 Wisconsin Ave, Milwaukee, WI 53226. Electronic address: vsabchyshyn@mcw.edu.
[Ti] Title:Concurrence of rheumatoid arthritis and calcium pyrophosphate deposition disease: A case collection and review of the literature.
[So] Source:Semin Arthritis Rheum;, 2017 Dec 02.
[Is] ISSN:1532-866X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Calcium pyrophosphate deposition disease (CPDD) is arthritis caused by calcium pyrophosphate (CPP) crystal deposition in joints. It is commonly associated with aging as well as a handful of metabolic syndromes. Recent epidemiologic studies suggest a positive association of CPDD and rheumatoid arthritis (RA). Yet how these diseases are related remains unclear. We set out to describe 21 well-characterized patients with both diagnoses. METHODS: Medical records of patients with both RA and CPDD identified at a single academic practice site were reviewed for age, gender, age of CPDD and RA onset, disease duration, joint involvement, and lab values including rheumatoid factor (RF), cyclic citrullinated peptide antibody (CCP), iron studies, and parathyroid hormone and calcium levels. RESULTS: The mean age of CPDD onset was 69.5 ± 11.4 years, with a mean RA age onset of 53.9 ± 16 years, demonstrating a mean lag of 13.4 ± 10.9 years between diagnoses. The majority of RA patients were diagnosed with CPDD based on the presence of radiographic chondrocalcinosis (15/21). The most commonly involved joint was the knee, followed by the wrist, hip, and shoulder. CONCLUSIONS: These data show that the diagnosis of RA often precedes the diagnosis of CPDD. This asynchronous presentation taken together with the classic age of onset for CPDD and typical pattern of joint involvement supports the hypothesis that CPDD develops in RA patients through similar processes as those that cause the idiopathic forms of this disease.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180117
[Lr] Last revision date:180117
[St] Status:Publisher

  4 / 2131 MEDLINE  
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[PMID]: 29236161
[Au] Autor:Taillandier A; Domingues C; Dufour A; Debiais F; Guggenbuhl P; Roux C; Cormier C; Cortet B; Porquet-Bordes V; Coury F; Geneviève D; Chiesa J; Colin T; Fletcher E; Guichet A; Javier RM; Laroche M; Laurent M; Lausch E; LeHeup B; Lukas C; Schwabe G; van der Burgt I; Muti C; Simon-Bouy B; Mornet E
[Ad] Address:Unité de Génétique Constitutionnelle, Service de Biologie, Centre Hospitalier de Versailles, 177 rue de Versailles, 78150, Le Chesnay, France.
[Ti] Title:Genetic analysis of adults heterozygous for ALPL mutations.
[So] Source:J Bone Miner Metab;, 2017 Dec 13.
[Is] ISSN:1435-5604
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:Hypophosphatasia (HPP) is a rare inherited metabolic bone disease due to a deficiency of the tissue nonspecific alkaline phosphatase isoenzyme (TNSALP) encoded by the ALPL gene. Patients have consistently low serum alkaline phosphatase (AP), so that this parameter is a good hallmark of the disease. Adult HPP is heterogeneous, and some patients present only mild nonpathognomonic symptoms which are also common in the general population such as joint pain, osteomalacia and osteopenia, chondrocalcinosis, arthropathy and musculoskeletal pain. Adult HPP may be recessively or dominantly inherited; the latter case is assumed to be due to the dominant negative effect (DNE) of missense mutations derived from the functional homodimeric structure of TNSALP. However, there is no biological argument excluding the possibility of other causes of dominant HPP. Rheumatologists and endocrinologists are increasingly solicited for patients with low AP and nonpathognomonic symptoms of HPP. Many of these patients are heterozygous for an ALPL mutation and a challenging question is to determine if these symptoms, which are also common in the general population, are attributable to their heterozygous ALPL mutation or not. In an attempt to address this question, we reviewed a cohort of 61 adult patients heterozygous for an ALPL mutation. Mutations were distinguished according to their statistical likelihood to show a DNE. One-half of the patients carried mutations predicted with no DNE and were slightly less severely affected by the age of onset, serum AP activity and history of fractures. We hypothesized that these mutations result in another mechanism of dominance or are recessive alleles. To identify other genetic factors that could trigger the disease phenotype in heterozygotes for potential recessive mutations, we examined the next-generation sequencing results of 32 of these patients for a panel of 12 genes involved in the differential diagnosis of HPP or candidate modifier genes of HPP. The heterozygous genotype G/C of the COL1A2 coding SNP rs42524 c.1645C > G (p.Pro549Ala) was associated with the severity of the phenotype in patients carrying mutations with a DNE whereas the homozygous genotype G/G was over-represented in patients carrying mutations without a DNE, suggesting a possible role of this variant in the disease phenotype. These preliminary results support COL1A2 as a modifier gene of HPP and suggest that a significant proportion of adult heterozygotes for ALPL mutations may have unspecific symptoms not attributable to their heterozygosity.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171213
[Lr] Last revision date:171213
[St] Status:Publisher
[do] DOI:10.1007/s00774-017-0888-6

  5 / 2131 MEDLINE  
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[PMID]: 29199508
[Au] Autor:Kang G; Leow MQH; Tay SC
[Ad] Address:Singapore General Hospital, Singapore.
[Ti] Title:Wrist inflammation: a retrospective comparison between septic and non-septic arthritis.
[So] Source:J Hand Surg Eur Vol;:1753193417738166, 2017 Jan 01.
[Is] ISSN:2043-6289
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:This study aims to identify differences in demographics, clinical and laboratory data between wrist septic arthritis and non-septic arthritis in patients admitted for wrist inflammation. A retrospective review of inpatients from May 2012 to April 2015 was conducted. Seventy-seven patients were included. Non-septic arthritis patients were more likely to have chronic kidney disease, pre-existing gout, or both. All septic arthritis patients had normal serum uric acid levels, and two or more raised inflammatory markers (white cell count, C-reactive protein, erythrocyte sedimentation rate). In patients with isolated wrist inflammation, the mean C-reactive protein in the septic arthritis group was significantly higher compared with the non-septic arthritis group (mean difference 132 mg/L, 95% CI 30.9-234). In this study, polyarticular involvement did not exclude a septic cause; nor did it imply a non-septic aetiology. Diabetic or immunosuppressed patients were not more likely to develop septic arthritis. The presence of chondrocalcinosis on wrist radiographs was virtually diagnostic of non-septic arthritis. LEVEL OF EVIDENCE: IV.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171204
[Lr] Last revision date:171204
[St] Status:Publisher
[do] DOI:10.1177/1753193417738166

  6 / 2131 MEDLINE  
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[PMID]: 29104755
[Au] Autor:Couto AR; Parreira B; Thomson R; Soares M; Power DM; Stankovich J; Armas JB; Brown MA
[Ad] Address:Serviço Especializado de Epidemiologia e Biologia Molecular (SEEBMO), Hospital de Santo Espírito da Ilha Terceira (HSEIT), Angra do Heroísmo, Portugal.
[Ti] Title:Combined approach for finding susceptibility genes in DISH/chondrocalcinosis families: whole-genome-wide linkage and IBS/IBD studies.
[So] Source:Hum Genome Var;4:17041, 2017.
[Is] ISSN:2054-345X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Twelve families with exuberant and early-onset calcium pyrophosphate dehydrate chondrocalcinosis (CC) and diffuse idiopathic skeletal hyperostosis (DISH), hereafter designated DISH/CC, were identified in Terceira Island, the Azores, Portugal. Ninety-two (92) individuals from these families were selected for whole-genome-wide linkage analysis. An identity-by-descent (IBD) analysis was performed in 10 individuals from 5 of the investigated pedigrees. The chromosome area with the maximal logarithm of the odds score (1.32; =0.007) was not identified using the IBD/identity-by-state (IBS) analysis; therefore, it was not investigated further. From the IBD/IBS analysis, two candidate genes, and , were identified and sequenced. Nine genetic variants were identified in the gene; one regulatory variant (rs146447064) was significantly more frequent in control individuals than in DISH/CC patients ( =0.03). Four variants were identified in , and the rs201930700 variant was further investigated using segregation analysis. None of the genetic variants in or segregated within the studied families. Therefore, although a major genetic effect was shown to determine DISH/CC occurrence within these families, the specific genetic variants involved were not identified.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171108
[Lr] Last revision date:171108
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1038/hgv.2017.41

  7 / 2131 MEDLINE  
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[PMID]: 29101102
[Au] Autor:Fernandes GS; Parekh SM; Moses J; Fuller C; Scammell B; Batt ME; Zhang W; Doherty M
[Ad] Address:Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham City Hospital, Nottingham, UK.
[Ti] Title:Prevalence of knee pain, radiographic osteoarthritis and arthroplasty in retired professional footballers compared with men in the general population: a cross-sectional study.
[So] Source:Br J Sports Med;, 2017 Nov 03.
[Is] ISSN:1473-0480
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVES: To determine the prevalence of knee pain, radiographic knee osteoarthritis (RKOA), total knee replacement (TKR) and associated risk factors in male ex-professional footballers compared with men in the general population (comparison group). METHODS: 1207 male ex-footballers and 4085 men in the general population in the UK were assessed by postal questionnaire. Current knee pain was defined as pain in or around the knees on most days of the previous month. Presence and severity of RKOA were assessed on standardised radiographs using the Nottingham Line Drawing Atlas (NLDA) in a subsample of 470 ex-footballers and 491 men in the comparison group. The adjusted risk ratio (aRR) and adjusted risk difference (aRD) with 95% CI in ex-footballers compared with the general population were calculated using the marginal model in Stata. RESULTS: Ex-footballers were more likely than the comparison group to have current knee pain (aRR 1.91, 95% CI 1.77 to 2.06), RKOA (aRR 2.21, 95% CI 1.92 to 2.54) and TKR (aRR 3.61, 95% CI 2.90 to 4.50). Ex-footballers were also more likely to present with chondrocalcinosis (aRR 3.41, 95% CI 2.44 to 4.77). Prevalence of knee pain and RKOA were higher in ex-footballers at all ages. However, even after adjustment for significant knee injury and other risk factors, there was more than a doubling of risk of these outcomes in footballers. CONCLUSIONS: The prevalence of all knee osteoarthritis outcomes (knee pain, RKOA and TKR) were two to three times higher in male ex-footballers compared with men in the general population group. Knee injury is the main attributable risk factor. Even after adjustment for recognised risk factors, knee osteoarthritis appear to be an occupational hazard of professional football.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171104
[Lr] Last revision date:171104
[St] Status:Publisher

  8 / 2131 MEDLINE  
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[PMID]: 29065924
[Au] Autor:Zeng C; Wei J; Terkeltaub R; Yang T; Choi HK; Wang YL; Xie DX; Hunter DJ; Zhang Y; Li H; Cui Y; Li LJ; Lei GH
[Ad] Address:Department of Orthopaedics, Xiangya Hospital, Central South University, #87 Xiangya Road, Changsha, Hunan Province, 410008, China.
[Ti] Title:Dose-response relationship between lower serum magnesium level and higher prevalence of knee chondrocalcinosis.
[So] Source:Arthritis Res Ther;19(1):236, 2017 Oct 24.
[Is] ISSN:1478-6362
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: The aim was to assess serum magnesium levels in relation to prevalence of knee chondrocalcinosis in two population-based Chinese studies. METHODS: Data included in this analysis consisted of two population-based cross-sectional studies, i.e., the Xiangya Hospital Health Management Center Study and the Xiangya Osteoarthritis (XO) Study I. A bilateral knee anteroposterior radiograph was obtained from each subject. Radiographic knee chondrocalcinosis was present if there was definite linear cartilage calcification. Serum magnesium concentration was measured using the chemiluminescence method. We examined the relation of serum magnesium levels to prevalence of knee chondrocalcinosis using generalized estimating equations. RESULTS: The prevalence of knee chondrocalcinosis was 1.4% in the Xiangya Hospital Health Management Center Study (n = 12,631). Compared with the lowest tertile, the age, sex and body mass index (BMI)-adjusted odds ratios (ORs) of chondrocalcinosis were 0.59 (95% CI 0.40-0.87) and 0.49 (95% CI 0.33-0.72) in the second and the third tertiles of serum magnesium, respectively (P for trend <0.001). The prevalence of knee chondrocalcinosis in the XO Study I (n = 1316) was 4.1%. The age, sex and BMI-adjusted ORs of chondrocalcinosis were 0.67 (95% CI 0.34-1.30) in the second and 0.45 (95% CI 0.21-0.94) in the third tertile of serum magnesium when compared with the lowest tertile (P for trend = 0.030). Similar results were observed in men and women in both studies. Adjusting for additional potential confounders did not change the results materially. CONCLUSIONS: Subjects with lower levels of serum magnesium, even within the normal range, had higher prevalence of knee chondrocalcinosis in a dose-response relationship manner, suggesting that magnesium may have a preventive or therapeutic potential for knee chondrocalcinosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171102
[Lr] Last revision date:171102
[St] Status:In-Process
[do] DOI:10.1186/s13075-017-1450-6

  9 / 2131 MEDLINE  
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[PMID]: 28965942
[Au] Autor:Forien M; Combier A; Gardette A; Palazzo E; Dieudé P; Ottaviani S
[Ad] Address:Service de rhumatologie, hôpital Bichat, université Paris Diderot, AP-HP, 46, rue Henri-Huchard, 75018 Paris, France.
[Ti] Title:Comparison of ultrasonography and radiography of the wrist for diagnosis of calcium pyrophosphate deposition.
[So] Source:Joint Bone Spine;, 2017 Sep 28.
[Is] ISSN:1778-7254
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Ultrasound (US) seems a useful tool for diagnosis of calcium pyrophosphate (CPP) deposition (CPPD). We aimed to compare the performance of US and conventional radiography of the wrist for diagnosis of CPPD. METHODS: Patients with CPP crystals identified in synovial fluid (SF) (knee, hip, shoulder, ankle or wrist) were consecutively included and compared to patients without CPP crystals in synovial fluid considered as controls. As recommended, we used the term chondrocalcinosis (CC) to assess imaging features suggesting CPPD. In all patients, US and radiographic assessment of CC of the wrists was performed by two distinct operators blinded each other (one operator by imaging modality). The two operators were blinded to clinical data, SF analysis and US or radiography findings. RESULTS: We included 32 CPPD patients and 26 controls. Among CPPD patients, US revealed CC in 30 (93.7%) and radiography in 17 (53.1%) (P<0.001). The sensitivity and specificity of US for the diagnosis of CPPD were 94% and 85%, respectively; the positive likelihood ratio (LR+) was 6.1. The sensitivity and specificity of radiography were 53.1% and 100%, respectively. At joints level independently of SF analysis, US revealed CC in 35 joints without radiographic CC whereas X-rays showed CC in 3 joints without US CC. The κ coefficient between US and radiography for CC was moderate: 0.33 (0.171-0.408). CONCLUSION: Our study suggests that wrist US should be considered as a relevant tool for the diagnosis of CPPD, with higher sensitivity than radiography for detecting CPP deposits.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171118
[Lr] Last revision date:171118
[St] Status:Publisher

  10 / 2131 MEDLINE  
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[PMID]: 28828349
[Au] Autor:Karimzadeh H; Sirous M; Sadati SN; Bashshash M; Mottaghi P; Ommani B; Karimifar M
[Ad] Address:Department of Rheumatology, Isfahan University of Medical Sciences, Isfahan, Iran.
[Ti] Title:Prevalence of Chondrocalcinosis in Patients above 50 Years and the Relationship with Osteoarthritis.
[So] Source:Adv Biomed Res;6:98, 2017.
[Is] ISSN:2277-9175
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:BACKGROUND: Some studies showed a relation between chondrocalcinosis and osteoarthritis (OA). Hence, considering the importance of chondrocalcinosis diagnosis andnecessity for its integration with OA, the current study aims at investigating prevalence of chondrocalcinosis in patients above 50 years admitted to Isfahan Al-Zahra Medical Center and its relationship with OA. MATERIALS AND METHODS: In a cross-sectional study, 600 patients who referred to the radiology units of Al-Zahra Hospital for radiography of different joints were studied during 2013-2014. The patients images were studied for chondrocalcinosis and OA by a radiologist and also examined clinically and results of imaging by an expert rheumatologist. The prevalence of chondrocalcinosis and it relation with OA was determined by Statistical Package for Social Sciences software and using of Chi-square and -test. RESULTS: 23 patients under study had chondrocalcinosis (3.83%). patients with chondrocalcinosis had higher age average, and they were in age group of 70 years and older, but no significant difference was observed regarding the prevalence of the disease in both genders. Chondrocalcinosis prevalence in terms of body mass index showed significant differences ( = 0.001). All patients with chondrocalcinosis had a history of joint disease and prevalence of chondrocalcinosis in terms of joint disease history showed a significant difference ( < 0.001). CONCLUSION: Prevalence of chondrocalcinosis is relatively high in the Iranian population of 70 years and older. Hence, more investigation considering to the diagnosis of chondrocalcinosis among patients with OA is very important.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170825
[Lr] Last revision date:170825
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/2277-9175.211835


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