Database : MEDLINE
Search on : Chondroma [Words]
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[PMID]: 29484408
[Au] Autor:Shi H; Chen W; Dong Y; Lu X; Zhang W; Wang L
[Ad] Address:Department of Pathology, The First Affiliated Hospital of Sun Yat­Sen University, Guangzhou, Guangdong 510080, P.R. China.
[Ti] Title:BAG3 promotes chondrosarcoma progression by upregulating the expression of ß-catenin.
[So] Source:Mol Med Rep;17(4):5754-5763, 2018 Apr.
[Is] ISSN:1791-3004
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:To investigate the roles of B­cell lymphoma­2 associated athanogene 3 (BAG3) in human chondrosarcoma and the potential mechanisms, the expression levels of BAG3 were detected in the present study, and the associations between BAG3 and clinical pathological parameters, clinical stage as well as the survival of patients were analyzed. The present study detected BAG3 mRNA and protein expression in the normal cartilage cell line HC­a and in SW1353 chondrosarcoma cells by reverse transcription­quantitative polymerase chain reaction and western blot analysis. The BAG3 protein expression in 59 cases of chondrosarcoma, 30 patients with endogenous chondroma and 8 cases of normal cartilage was semi-quantitatively analyzed using the immunohistochemical method. In addition, the BAG3 protein expression level, the clinical pathological parameters, clinical stage and the survival time of patients with chondrosarcoma were analyzed. The plasmid transfection method was employed to upregulate the expression BAG3 and small RNA interference to downregulate the expression of BAG3 in SW1353 cells. The expression levels of BAG3 protein and mRNA were significantly increased in the chondrosarcoma cell line when compared with the normal cartilage cell line. The immunohistochemistry results indicated that BAG3 protein was overexpressed in the tissue of human chondrosarcoma. Statistical analysis showed that the expression level of BAG3 was significantly increased in the different Enneking staging of patients with chondrosarcoma and Tumor staging, and there were no statistical differences in age, gender, histological classification and tumor size. In the in vitro experiments, the data revealed that BAG3 significantly promoted chondrosarcoma cell proliferation, colony­formation, migration and invasion; however, it inhibited chondrosarcoma cell apoptosis. It was observed that BAG3 upregulated ß­catenin expression at the mRNA and protein levels. In addition, BAG3 induced the expression of runt­related transcription factor 2 (RUNX2) in chondrosarcoma cells by upregulating ß­catenin. These clinical analyses revealed a positive association between ß­catenin and BAG3 in chondrosarcoma tumors. BAG3 was significantly increased in chondrosarcoma cells and tissues compared with the normal cartilage cells, tissue and cartilage benign tumors. Thus, BAG3 may serve as an oncogene in the development of chondrosarcoma via the induction of RUNX2 expression. The results of the present study contribute to further research on the biological development of chondrosarcoma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process
[do] DOI:10.3892/mmr.2018.8611

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[PMID]: 29252631
[Au] Autor:Lasater P; Steensma MR; Patthanacharoenphon C; Davis MM
[Ad] Address:Grand Rapids Medical Education Partners, Grand Rapids, Michigan.
[Ti] Title:Enchondroma Protuberans of the Ulna in a Pediatric Patient: A Case Report.
[So] Source:JBJS Case Connect;6(3):e54, 2016 Jul-Sep.
[Is] ISSN:2160-3251
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:CASE: We report the case of a 3-year-old boy who presented with a distal ulnar fracture through a mixed sclerotic and lytic expansile lesion. The underlying lesion, an enchondroma protuberans, can mimic either benign or malignant bone tumors. It was successfully treated with casting and intralesional treatment. CONCLUSION: Enchondroma protuberans is a rare entity that mimics enchondroma, osteochondroma, periosteal chondroma, or chondrosarcoma. Diagnosis is typically made through both radiographic and histologic means. In this case, the pathologic fracture was successfully treated with casting followed by intralesional curettage and bone-grafting. There was no evidence of recurrence at 18 months.
[Mh] MeSH terms primary: Bone Neoplasms/diagnosis
Chondroma/diagnosis
Ulna/pathology
[Mh] MeSH terms secundary: Bone Neoplasms/pathology
Child, Preschool
Chondroma/pathology
Humans
Male
Ulna/diagnostic imaging
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[Js] Journal subset:IM
[Da] Date of entry for processing:171219
[St] Status:MEDLINE
[do] DOI:10.2106/JBJS.CC.15.00241

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[PMID]: 29424182
[Au] Autor:Cui Y; Yue WJ; Lian F; Chen HC; Qu J
[Ad] Address:Department of Orthopaedics, the Fourth Hospital Affiliated to Haerbin Medical University, Haerbin 150001, Heilongjiang, China.
[Ti] Title:[A case report of extraskeletal chondroma on knee joint].
[So] Source:Zhongguo Gu Shang;30(6):573-575, 2017 Jun 25.
[Is] ISSN:1003-0034
[Cp] Country of publication:China
[La] Language:chi
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1802
[Cu] Class update date: 180209
[Lr] Last revision date:180209
[Cl] Clinical Trial:ClinicalTrial
[St] Status:In-Process
[do] DOI:10.3969/j.issn.1003-0034.2017.06.018

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[PMID]: 29414518
[Au] Autor:Gholamrezanezhad A; Basques K; Kosmas C
[Ad] Address:Departments of Emergency Radiology and Musculoskeletal Imaging, Keck School of Medicine, University of Southern California (USC), 1520 San Pablo St, Los Angeles, CA 90033, USA. Electronic address: a.gholamrezanezhad@yahoo.com.
[Ti] Title:Peering beneath the surface: Juxtacortical tumors of bone (part I).
[So] Source:Clin Imaging;51:1-11, 2018 Jan 27.
[Is] ISSN:1873-4499
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Juxtacortical or surface tumors of bone are neoplasms arising from or just outside the cortex, and are composed of different histologic types. Although the imaging appearances of these lesions have similarities to their intramedullary counterparts, their location alters their radiographic and MR characteristics, creating difficulties in diagnosis. Meanwhile, several non-neoplastic lesions, such as stress reaction/stress fracture and indolent infectious processes, compound the differential diagnosis. Neoplastic juxtacortical lesions of bone have been classified into five categories: cartilaginous, fibrous, lipomatous, osseous, and metastatic tumors. Our goal in part one of this review is to illustrate the characteristic radiographic, CT and MR imaging features of various juxtacortical neoplasms, including pathognomonic imaging findings that can aid in diagnosis, and to develop an appropriate differential diagnosis for surface lesions based on imaging characteristics, lesion location and patient age.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180207
[Lr] Last revision date:180207
[St] Status:Publisher

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[PMID]: 29413778
[Au] Autor:Rolvien T; Zustin J; Amling M; Yastrebov O
[Ad] Address:Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Lottestr. 59, 22529 Hamburg, Germany; Department of Orthopaedic Surgery, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany. Electronic address: t.rolvien@uke.de.
[Ti] Title:Periosteal chondroma of the cuboid with secondary aneurysmal bone cyst in a setting of secondary hyperparathyroidism.
[So] Source:Foot Ankle Surg;24(1):71-75, 2018 Feb.
[Is] ISSN:1460-9584
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:We report the case of a 35-year-old woman with painful, nontender mass at the right lateral hindfoot. Computed tomography (CT) and magnetic resonance imaging (MRI) indicated the suspect of a chondroid tumour in the cuboid. The tumour was resected en bloc and histology revealed the presence of a periosteal (juxtacortical) chondroma with secondary aneurysmal bone cyst. Secondary hyperparathyroidism was detected in laboratory tests and put into context with the histopathologic findings. In conclusion, a rare case of periosteal chondroma of the cuboid with secondary aneurysmal bone cyst in a setting of secondary hyperparathyroidism due to vitamin D deficiency is presented. LEVEL OF CLINICAL EVIDENCE: 4.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180207
[Lr] Last revision date:180207
[St] Status:In-Process

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[PMID]: 29353715
[Au] Autor:Gholamrezanezhad A; Basques K; Kosmas C
[Ad] Address:Department of Radiology, Cleveland Medical Center, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH, USA. Electronic address: ali.gholamrezanezhad@med.usc.edu.
[Ti] Title:Peering beneath the surface: juxtacortical tumors of bone (part II).
[So] Source:Clin Imaging;50:113-122, 2018 Jan 11.
[Is] ISSN:1873-4499
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Juxtacortical or surface tumors of bone are neoplasms arising from or just outside the cortex, and are composed of different histologic types. Although the imaging appearances of these lesions have similarities to their intramedullary counterparts, their location alters their radiographic and MR characteristics, creating difficulties in diagnosis. Meanwhile, several non-neoplastic lesions, such as stress reaction/stress fracture and indolent infectious processes, compound the differential diagnosis. Neoplastic juxtacortical lesions of bone have been classified into five categories: cartilaginous, fibrous, lipomatous, osseous, and metastatic tumors. Our goal in part two of this review is to illustrate the characteristic radiographic, CT and MR imaging features of various juxtacortical neoplasms, including pathognomonic imaging findings that can aid in diagnosis, and to develop an appropriate differential diagnosis for surface lesions based on imaging characteristics, lesion location and patient age.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1801
[Cu] Class update date: 180122
[Lr] Last revision date:180122
[St] Status:Publisher

  7 / 3436 MEDLINE  
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[PMID]: 29339836
[Au] Autor:Schaefer IM; Hornick JL; Bovée JVMG
[Ad] Address:Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
[Ti] Title:The role of metabolic enzymes in mesenchymal tumors and tumor syndromes: genetics, pathology, and molecular mechanisms.
[So] Source:Lab Invest;, 2018 Jan 16.
[Is] ISSN:1530-0307
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The discovery of mutations in genes encoding the metabolic enzymes isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH), and fumarate hydratase (FH) has expanded our understanding not only of altered metabolic pathways but also epigenetic dysregulation in cancer. IDH1/2 mutations occur in enchondromas and chondrosarcomas in patients with the non-hereditary enchondromatosis syndromes Ollier disease and Maffucci syndrome and in sporadic tumors. IDH1/2 mutations result in excess production of the oncometabolite (D)-2-hydroxyglutarate. In contrast, SDH and FH act as tumor suppressors and genomic inactivation results in succinate and fumarate accumulation, respectively. SDH deficiency may result from germline SDHA, SDHB, SDHC, or SDHD mutations and is found in autosomal-dominant familial paraganglioma/pheochromocytoma and Carney-Stratakis syndrome, describing the combination of paraganglioma and gastrointestinal stromal tumor (GIST). In contrast, patients with the non-hereditary Carney triad, including paraganglioma, GIST, and pulmonary chondroma, usually lack germline SDH mutations and instead show epigenetic SDH complex inactivation through SDHC promoter methylation. Inactivating FH germline mutations are found in patients with hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome comprising benign cutaneous/uterine leiomyomas and renal cell carcinoma. Mutant IDH, SDH, and FH share common inhibition of α-ketoglutarate-dependent oxygenases such as the TET family of 5-methylcytosine hydroxylases preventing DNA demethylation, and Jumonji domain histone demethylases increasing histone methylation, which together inhibit cell differentiation. Ongoing studies aim to better characterize these complex alterations in cancer, the different clinical phenotypes, and variable penetrance of inherited and sporadic cancer predisposition syndromes. A better understanding of the roles of metabolic enzymes in cancer may foster the development of therapies that specifically target functional alterations in tumor cells in the future. Here, the physiologic functions of these metabolic enzymes, the mutational spectrum, and associated functional alterations will be discussed, with a focus on mesenchymal tumor predisposition syndromes.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1801
[Cu] Class update date: 180117
[Lr] Last revision date:180117
[St] Status:Publisher
[do] DOI:10.1038/s41374-017-0003-6

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[PMID]: 29202349
[Au] Autor:Arouj HA; AlBader AK; Bhat IN
[Ad] Address:Otolaryngology department, Farwaniya Hospital, Kuwait.
[Ti] Title:Chondrometaplasia of the vocal cord in an adult male.
[So] Source:Int J Surg Case Rep;42:10-12, 2017 Nov 22.
[Is] ISSN:2210-2612
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:INTRODUCTION: (Chondrometaplasia of the larynx is a rare disease. We report a case that presented at the otolaryngology department in our institute in 2015.) PRESENTATION OF CASE: A 62year old man without any history of trauma presented with progressive dysphonia, dyspnoea, without any dysphagia. A fibreoptic laryngoscopic examination revealed nodular mass arising at the junction of anterior 1/3rd and posterior 2/3rd of left vocal cord. DISCUSSION: A computed tomography scan of the neck region showed a rounded and circumscribed mass without infiltration of the surrounding tissues. Histological investigation of the lesion revealed the presence of fibroelastic cartilaginous tissue, surrounded by a thin rim of fibrous tissue, with rare hypercellular areas, occasional binucleated cells, slight hyperchromasia, and an irregular nuclear profile. Mitotic activity was absent. CONCLUSION: The patient didn't have history of laryngeal trauma. Subacute and progressive onset of clinical symptoms and histological and radiological findings helps to distinguish the chondrometaplastic nature from true laryngeal cartilaginous tumours, such as chondroma and low grade chondrosarcoma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171220
[Lr] Last revision date:171220
[St] Status:Publisher

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[PMID]: 29252024
[Au] Autor:Prins D; Fuchs L
[Ti] Title:Extraskeletal Chondroma with Concomitant Arthrosis of the Foot at the First Metatarsophalangeal Joint .
[So] Source:J Am Podiatr Med Assoc;107(6):561-564, 2017 Nov.
[Is] ISSN:1930-8264
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Extraskeletal chondroma is a benign tumor that is found most often in the fingers but can be found in the feet as well. A symptom of this lesion is pressure from the slow-growing mass. We present the case of a 58-year-old woman who presented with an extraskeletal chondroma in the plantar aspect of the left first metatarsophalangeal joint with concomitant symptomatic arthrosis at the joint. Operative treatment was excision of the lesion in addition to arthrodesis of the joint attributable to the presence of symptomatic arthrosis. The patient was seen approximately 1 year postoperatively and had no postoperative complications. Distinction between extraskeletal chondromas and other lesions, such as extraskeletal myxoid chondrosarcomas, is critical because delayed treatment of the latter has the propensity to lead to detriment to the patient. Therefore, proper diagnosis is critical.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171218
[Lr] Last revision date:171218
[St] Status:In-Process
[do] DOI:10.7547/15-047

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[PMID]: 29239034
[Au] Autor:Gill AJ
[Ad] Address:Department of Anatomical Pathology, Royal North Shore Hospital, St Leonards, NSW, Australia.
[Ti] Title:Succinate dehydrogenase (SDH)-deficient neoplasia.
[So] Source:Histopathology;72(1):106-116, 2018 Jan.
[Is] ISSN:1365-2559
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The succinate dehydrogenase (SDH) complex is a key respiratory enzyme composed of four subunits: SDHA, SDHB, SDHC and SDHD. Remarkably, immunohistochemistry for SDHB becomes negative whenever there is bi-alleic inactivation of any component of SDH, which is very rare in the absence of syndromic disease. Therefore, loss of SDHB immunohistochemistry serves as a marker of syndromic disease, usually germline mutation of one of the SDH subunits. Tumours which show loss of SDHB expression are termed succinate dehydrogenase-deficient. In addition to loss of SDHB, tumours associated with SDHA mutation also show loss of SDHA expression. Fifteen per cent of pheochromocytoma and paraganglioma (PHEO/PGL) are associated with germline SDH mutation, and therefore SDH-deficient. We recommend screening SDHB immunohistochemistry for all PHEO/PGL. SDH-deficient gastrointestinal stromal tumours (GISTs) show distinctive features, including absent KIT proto-oncogene receptor tyrosine kinase/platelet-derived growth factor receptor A (KIT/PDGFRA) mutations [but positive staining for cKIT and DOG1], virtually exclusive gastric location, lobulated growth, multi-focality, a prognosis not predicted by size and mitotic rate, frequent metastasis to lymph nodes and primary resistance to imatinib therapy. Thirty per cent are associated with SDHA germline mutation and 50% are associated with SDHC epimutation (post-zygotic promoter hypermethylation) - the hallmark of the syndromic but non-hereditary Carney triad (SDH- deficient GIST, SDH-deficient paraganglioma and pulmonary chondroma). SDH-deficient renal carcinoma is newly recognized under the World Health Organization (WHO) 2016 classification and shows vacuolated eosinophilic cytoplasmic and cytoplasmic inclusions. It is particularly associated with SDHB mutation, although SDHC and SDHA mutation occur. SDH-deficient pituitary adenomas are recognized, but appear to be the least common SDH-deficient neoplasm.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1712
[Cu] Class update date: 171214
[Lr] Last revision date:171214
[St] Status:In-Process
[do] DOI:10.1111/his.13277


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