Database : MEDLINE
Search on : Coccidioidomycosis [Words]
References found : 2633 [refine]
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[PMID]: 28084574
[Au] Autor:Colson AJ; Vredenburgh L; Guevara RE; Rangel NP; Kloock CT; Lauer A
[Ad] Address:Department of Biology, California State University Bakersfield (CSUB), 9001 Stockdale Highway, Bakersfield, CA, 93311-1022, USA.
[Ti] Title:Large-Scale Land Development, Fugitive Dust, and Increased Coccidioidomycosis Incidence in the Antelope Valley of California, 1999-2014.
[So] Source:Mycopathologia;182(5-6):439-458, 2017 Jun.
[Is] ISSN:1573-0832
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Ongoing large-scale land development for renewable energy projects in the Antelope Valley, located in the Western Mojave Desert, has been blamed for increased fugitive dust emissions and coccidioidomycosis incidence among the general public in recent years. Soil samples were collected at six sites that were destined for solar farm construction and were analyzed for the presence of the soil-borne fungal pathogen Coccidioides immitis which is endemic to many areas of central and southern California. We used a modified culture-independent nested PCR approach to identify the pathogen in all soil samples and also compared the sampling sites in regard to soil physical and chemical parameters, degree of disturbance, and vegetation. Our results indicated the presence of C. immitis at four of the six sites, predominantly in non-disturbed soils of the Pond-Oban complex, which are characterized by an elevated pH and salt bush communities, but also in grassland characterized by different soil parameters and covered with native and non-native annuals. Overall, we were able to detect the pathogen in 40% of the soil samples (n = 42). Incidence of coccidioidomycosis in the Antelope Valley was positively correlated with land use and particulate matter in the air (PM10) (Pearson correlation coefficient >0.5). With the predicted population growth and ongoing large-scale disturbance of soil in the Antelope Valley in coming years, incidence of coccidioidomycosis will likely further increase if policy makers and land developers continue to ignore the risk of grading land without implementing long-term dust mitigation plans in Environmental Impact Reports.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1701
[Cu] Class update date: 171030
[Lr] Last revision date:171030
[St] Status:In-Process
[do] DOI:10.1007/s11046-016-0105-5

  2 / 2633 MEDLINE  
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[PMID]: 28289027
[Au] Autor:Shubitz LF; Roy ME; Trinh HT; Hoekstra WJ; Schotzinger RJ; Garvey EP
[Ad] Address:Valley Fever Center for Excellence, The University of Arizona, Tucson, Arizona, USA Lfshubit@email.arizona.edu.
[Ti] Title:Efficacy of the Investigational Antifungal VT-1161 in Treating Naturally Occurring Coccidioidomycosis in Dogs.
[So] Source:Antimicrob Agents Chemother;61(5), 2017 May.
[Is] ISSN:1098-6596
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Coccidioidomycosis can be a chronic, systemic fungal infection requiring long-term to lifetime medication. Thus, there is a need for improved antifungal agents with greater efficacy and reduced toxicity. VT-1161 has a low affinity for mammalian cytochromes and potently inhibits fungal CYP51 with proven efficacy in murine models of central nervous system (CNS) and respiratory coccidioidomycosis. Dogs experience coccidioidomycosis similar to humans and are a useful preclinical model for naturally occurring disease. Twenty-four client-owned dogs diagnosed with respiratory coccidioidomycosis based on radiography, serology, clinical signs, and clinicopathologic abnormalities were treated with a loading dose of VT-1161 for 14 days, followed by 46 days of a lower maintenance dose. Twelve dogs received a high dose (29 mg/kg loading, 6 mg/kg maintenance) and 12 received a low dose (10 mg/kg loading, 1.6 mg/kg maintenance). Response to treatment was assessed by calculating the reduction in disease scores at exit compared to disease scores at enrollment. Overall, 20 of 24 (83%) dogs had ≥50% reduction in enrollment disease scores at exit ( < 0.001), with no difference between the high- and low-dose groups ( = 0.66). Time-weighted average plasma concentrations for the high- and low-dose groups were 39 ± 5 µg/ml and 19 ± 2 µg/ml, respectively. In this open-label study, VT-1161 was efficacious for the treatment of respiratory coccidioidomycosis in naturally infected dogs. Combined with previously reported murine data, this finding supports the further development of VT-1161 for the treatment of coccidioidomycosis in humans.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1703
[Cu] Class update date: 171024
[Lr] Last revision date:171024
[St] Status:In-Process

  3 / 2633 MEDLINE  
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[PMID]: 29053941
[Au] Autor:Nicas M
[Ad] Address:a School of Public Health, University of California , Berkeley , CA.
[Ti] Title:A point-source outbreak of coccidioidomycosis among a highway construction crew.
[So] Source:J Occup Environ Hyg;:0, 2017 Oct 20.
[Is] ISSN:1545-9632
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Coccidioidomycosis is an infection caused by inhaling spores of the soil fungus Coccidioides immitis (hereafter termed Cocci). Cocci is endemic in certain areas of California. When soil containing the fungus is disturbed, as during earth-moving activities, respirable Cocci spores can become airborne and be inhaled by persons in the vicinity. This paper describes a cluster of seven Cocciodioidomycosis cases among a highway construction crew that occurred in June/July 2008 in Kern County, CA, which is among the most highly endemic regions for Cocci in California. The exposures spanned no more than seven work days, and illness developed within two to three weeks of the exposures. Given the common source of exposure (soil dust generated at the work site) and the multiple cases occurring close in time, the cluster can also be termed a "point-source outbreak." The contractor was not informed of the infection risk and did not take adequate precautions against dust exposure. Appropriate engineering/administrative controls and respiratory protection are discussed.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171020
[Lr] Last revision date:171020
[St] Status:Publisher
[do] DOI:10.1080/15459624.2017.1383612

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[PMID]: 28811115
[Au] Autor:Shahab R; Amra NK; Rabah R; Saunar J; Soriano J; Al-Tawfiq JA
[Ad] Address:Specialty Internal Medicine, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.
[Ti] Title:Recurrence of cutaneous coccidioidomycosis 6 years after valley fever: A case presentation and literature review.
[So] Source:Diagn Microbiol Infect Dis;89(3):218-221, 2017 Nov.
[Is] ISSN:1879-0070
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Coccidioidomycosis is usually acquired by inhalation of spores of Coccidioides immitis and C. posadasii. The disease ranges from a self-limited acute pneumonia (Valley Fever) to a disseminated disease. We present a 44-year-old healthy male who had patchy hair loss of several months duration resembling discoid lupus. He developed a firm non-scaly red plaque on the right forehead. Initial biopsy showed spongiotic dermatitis, and he was treated with systemic steroids. He then developed forehead and periorbital cellulitis and was treated with systemic antibiotics. A second biopsy showed fungal hyphae, and he was treated with itraconazole 200mg bid for 4months beyond clinical resolution. A year later, he presented with intermittent swelling of the right forehead lesion and worsening of the scalp lesions. A forehead biopsy showed interface dermatitis and negative PAS stain for fungi. Scalp biopsy was highly suggestive of discoid lupus and he was started on plaquenil. Many months later, a third biopsy showed fungal infection, and the culture grew C. immitis. He was treated with itraconazole. Retrospectively, the patient gave a history of Valley fever 6 years back when he was in Arizona, USA.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 171020
[Lr] Last revision date:171020
[St] Status:In-Process

  5 / 2633 MEDLINE  
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[PMID]: 29032736
[Au] Autor:Zahid U; Shaukat AA; Hassan N; Anwer F
[Ad] Address:Department of Medicine, Division of Hematology, Oncology, Blood and marrow transplantation, University of Arizona, Tucson, AZ 85724, USA.
[Ti] Title:Coccidioidomycosis, immunoglobulin deficiency: safety challenges with CAR T cells therapy for relapsed lymphoma.
[So] Source:Immunotherapy;9(13):1061-1066, 2017 Oct.
[Is] ISSN:1750-7448
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Treatment of patients with relapsed or refractory lymphoma may require allogenic hematopoietic stem cell transplant (HSCT), but treatment of post-transplant relapse disease remains very challenging. Donor lymphocyte infusion and blinatumomab have been used with limited success for the treatment of relapse. Initial data on donor-derived CAR T cells has shown this modality to be safe and highly effective in various hematological malignancies. We present a case of a patient with highly refractory, transformed follicular lymphoma who failed both autologous and allogenic HSCT. Patient achieved long-lasting complete remission with the use of donor origin CD19 CAR T-cell therapy, without any evidence of graft-versus-host disease flare. Our patient later developed disseminated coccidioidomycosis and persistent hypogammaglobulinemia. Immunotherapy using CD19 CAR T cells can be a highly effective salvage modality, especially in cases of focal lymphoma relapse. Long-term immunosuppression secondary to B cell lymphopenia, hypogammaglobulinemia, immunoglobulin subclass deficiency, fungal infections and other infectious complications need to be monitored and promptly treated as indicated.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171016
[Lr] Last revision date:171016
[St] Status:In-Process
[do] DOI:10.2217/imt-2017-0070

  6 / 2633 MEDLINE  
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[PMID]: 28935008
[Au] Autor:Kundu MC; Ringenberg MA; d'Epagnier DL; Haag HL; Maguire S
[Ad] Address:Integrated Biological Platform Sciences, GlaxoSmithKline Research and Development, Collegeville, Pennsylvania, Veterinary Sciences, Bristol-Myers Squibb, New Brunswick, New Jersey.
[Ti] Title:Coccidioidomycosis in an Indoor-housed Rhesus Macaque ( ).
[So] Source:Comp Med;67(5):452-455, 2017 Oct 01.
[Is] ISSN:1532-0820
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Coccidioides spp. are saprophytic, dimorphic fungi that are endemic to arid climates, are capable of infecting many species, and result in diverse clinical presentations. An indoor-housed laboratory rhesus macaque presented with weight loss and decreased activity and appetite. During the diagnostic evaluation, a bronchiolar-alveolar pattern in the cranial lung lobes, consistent with bronchopneumonia, was noted on radiographs. Given the poor prognosis, the macaque was euthanized. Confirming the radiographic assessment, gross necropsy findings included multifocal to coalescing areas of consolidation in the right and left cranial lung lobes. Microscopically, the consolidated regions were consistent with a pyogranulomatous bronchopneumonia and contained round, nonbudding, fungal yeast structures considered to be morphologically consistent with Coccidioides immitis. Culture and colony morphology results were confirmed through additional diagnostic testing. Sequencing of the D1-D2 domain of the 28S large ribosomal subunit positively matched with a known sequence specific to C. immitis. Serology for Coccidioides spp. by both latex agglutination (IgM) and immunodiffusion (IgG) was positive. In this rhesus macaque, the concordant results from histology, culture, DNA sequencing, and serology were collectively used to confirm the diagnosis of coccidioidomycosis. This animal likely acquired a latent pulmonary infection with Coccidioides months prior to arrival, when housed outdoors in a Coccidioides-endemic area. The nonspecific clinical presentation in this macaque, coupled with the recent history of indoor housing and lag between clinical presentation and outdoor housing, can make similar diagnostic cases challenging and highlights the need for awareness regarding animal source when making an accurate diagnosis in an institutional laboratory setting.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171005
[Lr] Last revision date:171005
[St] Status:In-Process

  7 / 2633 MEDLINE  
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[PMID]: 28695649
[Au] Autor:Lohrmann GM; Vucicevic D; Lawrence R; Steidley DE; Scott RL; Kusne S; Blair JE
[Ad] Address:Mayo Clinic School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
[Ti] Title:Single-center experience of antifungal prophylaxis for coccidioidomycosis in heart transplant recipients within an endemic area.
[So] Source:Transpl Infect Dis;19(5), 2017 Oct.
[Is] ISSN:1399-3062
[Cp] Country of publication:Denmark
[La] Language:eng
[Ab] Abstract:In endemic regions, coccidioidomycosis causes substantial morbidity and mortality for patients receiving solid organ transplants. We aimed to demonstrate the effect of antifungal coccidioidal prophylaxis in heart transplant (HT) recipients. We retrospectively reviewed the electronic health records of all patients who received HTs between October 19, 2005, and December 13, 2014. We collected information regarding antifungal regimens and determined whether patients subsequently developed infections. Our 174-person cohort all received antifungal prophylaxis for at least 6 months (mean follow-up, 53.8 months). One proven and one probable coccidioidal infection (each, 0.6%) occurred during the study period. The incidence of coccidioidomycosis was 0.6% at 1 year and 2.3% at 5 years. No cases of proven coccidioidomycosis occurred within 2 years after transplantation. No patients developed disseminated disease, and no sentinel events were attributed to coccidioidomycosis. Both fluconazole and voriconazole were well tolerated. In the absence of intolerance or contraindication, we suggest continuing a universal antifungal prophylactic regimen with fluconazole for at least 6-12 months in HT recipients residing in a coccidioidomycosis-endemic area.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 171005
[Lr] Last revision date:171005
[St] Status:In-Process
[do] DOI:10.1111/tid.12744

  8 / 2633 MEDLINE  
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[PMID]: 28096163
[Au] Autor:Thompson GR; Barker BM; Wiederhold NP
[Ad] Address:Department of Medicine, Division of Infectious Diseases, University of California-Davis Medical Center, Sacramento, California, USA grthompson@ucdavis.edu.
[Ti] Title:Large-Scale Evaluation of Amphotericin B, Triazole, and Echinocandin Activity against Coccidioides Species from U.S. Institutions.
[So] Source:Antimicrob Agents Chemother;61(4), 2017 Apr.
[Is] ISSN:1098-6596
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Large-scale testing of isolates has not been performed, and the frequency of clinical isolates with elevated amphotericin B or triazole MICs has not been evaluated. isolates ( = 581) underwent antifungal susceptibility testing. Elevated MIC values were observed for fluconazole (≥16 µg/ml, 37.3% of isolates; ≥32 µg/ml, 7.9% of isolates), itraconazole (≥2 µg/ml, 1.0% of isolates), posaconazole (≥1 µg/ml, 1.0% of isolates), and voriconazole (≥2 µg/ml, 1.2% of isolates). However, mold-active triazoles exhibited low MICs for the majority of isolates tested. Additional correlation with patient outcomes to determine the relevance of elevated MICs in isolates is needed.
[Mh] MeSH terms primary: Amphotericin B/pharmacology
Antifungal Agents/pharmacology
Coccidioides/drug effects
Echinocandins/pharmacology
Triazoles/pharmacology
[Mh] MeSH terms secundary: Coccidioidomycosis/microbiology
Flucytosine/pharmacology
Itraconazole/pharmacology
Lipopeptides/pharmacology
Microbial Sensitivity Tests
United States
Voriconazole/pharmacology
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antifungal Agents); 0 (Echinocandins); 0 (Lipopeptides); 0 (Triazoles); 304NUG5GF4 (Itraconazole); 6TK1G07BHZ (posaconazole); 7XU7A7DROE (Amphotericin B); D83282DT06 (Flucytosine); F0XDI6ZL63 (caspofungin); JFU09I87TR (Voriconazole)
[Em] Entry month:1709
[Cu] Class update date: 170925
[Lr] Last revision date:170925
[Js] Journal subset:IM
[Da] Date of entry for processing:170118
[St] Status:MEDLINE

  9 / 2633 MEDLINE  
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[PMID]: 28889900
[Au] Autor:Hountras P; Cajigas H
[Ad] Address:Department of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL. Electronic address: peter.hountras@northwestern.edu.
[Ti] Title:A 62-Year-Old Woman With Wheezing, Respiratory Failure, and an Abnormal CT Scan.
[So] Source:Chest;152(3):e73-e76, 2017 Sep.
[Is] ISSN:1931-3543
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:CASE PRESENTATION: A previously healthy 62-year-old woman was transferred to the ICU from the medical ward with acute bronchospastic respiratory failure requiring intubation and mechanical ventilation. Four weeks before, the patient was vacationing in Arizona and acquired a mildly productive cough as well as mild dyspnea. She presented to an urgent care facility and was diagnosed with community-acquired pneumonia. She received a 5-day course of azithromycin, with partial improvement of her symptoms. The patient returned home 1 week prior to admission, reporting worsening dyspnea, chest pressure, cough, and fever. The patient was admitted to the medical ward, and treatment for unresolved pneumonia was begun with levofloxacin, an inhaled short-acting beta agonist, and oral prednisone. Despite this treatment, the patient experienced severe respiratory distress with audible wheezing as well as increased work of breathing. She was intubated for acute hypoxemic respiratory failure and transferred to the ICU.
[Mh] MeSH terms primary: Coccidioidomycosis/diagnostic imaging
Lung Diseases, Fungal/diagnostic imaging
Respiratory Insufficiency/microbiology
Respiratory Sounds/etiology
[Mh] MeSH terms secundary: Coccidioidomycosis/complications
Coccidioidomycosis/therapy
Critical Care
Female
Humans
Lung Diseases, Fungal/complications
Lung Diseases, Fungal/therapy
Middle Aged
Respiration, Artificial
Respiratory Insufficiency/diagnostic imaging
Respiratory Insufficiency/therapy
Respiratory Sounds/diagnosis
Tomography, X-Ray Computed
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170922
[Lr] Last revision date:170922
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:170911
[St] Status:MEDLINE

  10 / 2633 MEDLINE  
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[PMID]: 28419259
[Au] Autor:Thompson GR; Blair JE; Wang S; Bercovitch R; Bolaris M; Van Den Akker D; Lopez R; Heidari A; Catanzaro A; Cadena J; Chin-Hong P; Spellberg B; Johnson R
[Ad] Address:Department of Medical Microbiology and Immunology.
[Ti] Title:Adjunctive Corticosteroid Therapy in the Treatment of Coccidioidal Meningitis.
[So] Source:Clin Infect Dis;65(2):338-341, 2017 Jul 15.
[Is] ISSN:1537-6591
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Coccidioidal meningitis (CM) has high morbidity, and adjunctive measures to improve outcomes are needed. Using an established multicenter retrospective cohort study of CM (N = 221), we found that patients receiving adjunctive corticosteroids had a significant reduction in secondary cerebrovascular events (P = .0049). Those with CM-associated cerebrovascular events (8%) may benefit from short-term corticosteroids.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1704
[Cu] Class update date: 170921
[Lr] Last revision date:170921
[St] Status:In-Process
[do] DOI:10.1093/cid/cix318


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