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[PMID]: 29501674
[Au] Autor:Gao SM; Liu JS; Wang M; Cao TT; Qi YD; Zhang BG; Sun XB; Liu HT; Xiao PG
[Ad] Address:Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Peking Union Medical College), Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China. Electronic address: g
[Ti] Title:Traditional uses, phytochemistry, pharmacology and toxicology of Codonopsis: A review.
[So] Source:J Ethnopharmacol;, 2018 Feb 28.
[Is] ISSN:1872-7573
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:ETHNOPHARMACOLOGICAL RELEVANCE: Species of the genus Codonopsis are perennial herbs mainly distributed throughout East, Southeast and Central Asia. As recorded, they have been used as traditional Chinese medicines since the Qing Dynasty, where they were claimed for strengthening the spleen and tonifying the lung, as well as nourishing blood and engendering liquid. Some species are also used as food materials in southern China and Southeast Asia, such as tea, wine, soup, plaster, and porridge. AIM OF THE REVIEW: The review aims to assess the ethnopharmacological uses, explicit the material basis and pharmacological action, promote the safety of medical use, and suggest the future research potentials of Codonopsis. MATERIALS AND METHODS: Information on the studies of Codonopsis was collected from scientific journals, books, and reports via library and electronic data search (PubMed, Elsevier, Scopus, Google Scholar, Springer, Science Direct, Wiley, Researchgate, ACS, EMBASE, Web of Science and CNKI). Meanwhile, it is also obtained from published works of material medica, folk records, ethnopharmacological literatures, PhD and Masters Dissertation. Plant taxonomy is confirmed to the database "The Plant List" (www.theplantlist.org). RESULTS: Codonopsis has been used for medicinal purposes all around the world. Some species are also used as food materials in southern China and Southeast Asia. The chemical constituents of Codonopsis mainly are polyacetylenes, polyenes, flavonoids, lignans, alkaloids, coumarins, terpenoids, steroids, organic acids, saccharides, and so on. Extract of Codonopsis exhibit extensive pharmacological activities, including immune function regulation, hematopoiesis improvement, cardiovascular protection, neuroprotection, gastrointestinal function regulation, endocrine function regulation, cytotoxic and antibacterial effects, anti-aging and anti-oxidation, etc.. Almost no obvious toxicity or side effect are observed and recorded for Codonopsis. CONCLUSIONS: The traditional uses, phytochemistry, pharmacology and toxicology of Codonopsis are reviewed in this paper. Species of the genus have long been used as traditional medicines and food materials, they were reported with a large number of chemical constituents with different structures, extensive pharmacological activities in immune system, blood system, digestive system, etc. and almost no toxicity. More profound studies on less popular species, pharmacodynamic material basis and pharmacological mechanism, and quality assurance are suggested to be carried out to fulfil the research on the long-term clinical use and new drug research of Codonopsis.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180304
[Lr] Last revision date:180304
[St] Status:Publisher

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[PMID]: 29286105
[Au] Autor:Luan YP; Li QF; Wu SG; Mao DC; Deng YY; Chen RW
[Ad] Address:College of Life Sciences, Southwest Forestry University, Kunming, Yunnan 650224, P.R. China.
[Ti] Title:Tsoong induces apoptosis and inhibits proliferation, migration and invasion of pancreatic ductal adenocarcinoma cells.
[So] Source:Mol Med Rep;17(3):3527-3536, 2018 Mar.
[Is] ISSN:1791-3004
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:The roots of Codonopsis cordifolioidea (classified as campanulaceae cordifolioidea), locally known as Tsoong, have been used as a tonic food. The major components isolated from Tsoong have been demonstrated to present anti­human immunodeficiency virus­1 activities and cytotoxicity against various tumor cell lines. However, the possible effects of the novel compound isolated from Tsoong, cordifoliketones A, on pancreatic ductal adenocarcinoma (PDAC) cells, are still unknown. In the present study, cordifoliketones A extractions were prepared from Tsoong, and the possible effects on PDAC cell growth, apoptosis, migration and invasion in vitro and in vivo were exlored. The cytotoxicity assay, apoptosis assay, western blotting, migration and invasion assay, and a PDAC cell (AsPC­1, BxPC­3 and PANC­1) xenograft mice model were employed. The results demonstrated that treatment with cordifoliketones A: i) inhibited proliferation and promoted apoptosis of PDAC cells; ii) significantly induced apoptosis and altered expression of apoptosis­associated proteins in a dose­dependent manner; iii) suppressed migration and invasion of PDAC cells in a dose­dependent manner; and iv) restrained the growth of PDAC neoplasm in nude mice. Furthermore, cordifoliketones A demonstrated non­cytotoxic activity in a panel of normal human cells, including hTERT­HPNE, 293, hepatocyte HL­7702 and HL­1 cells. Therefore, these data indicated that cordifoliketones A may be a potential candidate compound for the prevention of PDAC cell proliferation and metastasis, presumably by induction apoptosis and inhibiting viability, invasion and migration of PDAC cells.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:In-Process
[do] DOI:10.3892/mmr.2017.8328

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[PMID]: 28471110
[Au] Autor:Luo Y; Li WL; Huang WH; Liu XH; Song YG; Qu HB
[Ad] Address:Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310058, China.
[Ti] Title:Rapid quantification of multi-components in alcohol precipitation liquid of Codonopsis Radix using near infrared spectroscopy (NIRS).
[So] Source:J Zhejiang Univ Sci B;18(5):383-392, 2017 May.
[Is] ISSN:1862-1783
[Cp] Country of publication:China
[La] Language:eng
[Ab] Abstract:A near infrared spectroscopy (NIRS) approach was established for quality control of the alcohol precipitation liquid in the manufacture of Codonopsis Radix. By applying NIRS with multivariate analysis, it was possible to build variation into the calibration sample set, and the Plackett-Burman design, Box-Behnken design, and a concentrating-diluting method were used to obtain the sample set covered with sufficient fluctuation of process parameters and extended concentration information. NIR data were calibrated to predict the four quality indicators using partial least squares regression (PLSR). In the four calibration models, the root mean squares errors of prediction (RMSEPs) were 1.22 µg/ml, 10.5 µg/ml, 1.43 µg/ml, and 0.433% for lobetyolin, total flavonoids, pigments, and total solid contents, respectively. The results indicated that multi-components quantification of the alcohol precipitation liquid of Codonopsis Radix could be achieved with an NIRS-based method, which offers a useful tool for real-time release testing (RTRT) of intermediates in the manufacture of Codonopsis Radix.
[Mh] MeSH terms primary: Codonopsis/chemistry
Drugs, Chinese Herbal/chemistry
Ethanol/chemistry
Fractional Precipitation/methods
Models, Statistical
Plant Extracts/chemistry
Spectroscopy, Near-Infrared/methods
[Mh] MeSH terms secundary: Complex Mixtures/analysis
Complex Mixtures/chemistry
Computer Simulation
Drugs, Chinese Herbal/analysis
Models, Chemical
Plant Extracts/analysis
Solutions/chemistry
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Complex Mixtures); 0 (Drugs, Chinese Herbal); 0 (Plant Extracts); 0 (Solutions); 3K9958V90M (Ethanol)
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[Js] Journal subset:IM
[Da] Date of entry for processing:170505
[St] Status:MEDLINE
[do] DOI:10.1631/jzus.B1600141

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[PMID]: 29439445
[Au] Autor:Zheng T; Cheng LZ; Yan YM; Liu BH; Qin FY; Xu FR; Cheng YX
[Ad] Address:College of Pharmacy, Yunnan University of Traditional Chinese Medicine, Kunming 650504, China. zhengtao@cuhk.edu.hk.
[Ti] Title:Two New Triterpenoids from the Roots of Codonopsis pilosula.
[So] Source:Molecules;23(2), 2018 Feb 11.
[Is] ISSN:1420-3049
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Pseudolarolides U and V, two new triterpenoids, and four biogenetically related compounds, pseudolarolides E, F, K, and P were isolated from the roots of (Campanulaceae). Their structures were determined by spectroscopic data. The regulation of Sirtuin 1 (SIRT1) activity by all the isolated compounds was evaluated.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180214
[Lr] Last revision date:180214
[St] Status:In-Process

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[PMID]: 29433673
[Au] Autor:Han AY; Lee YS; Kwon S; Lee HS; Lee KW; Seol GH
[Ad] Address:Department of Basic Nursing Science, College of Nursing, Korea University, Seoul 02841, Republic of Korea.
[Ti] Title:Codonopsis lanceolata extract prevents hypertension in rats.
[So] Source:Phytomedicine;39:119-124, 2018 Jan 15.
[Is] ISSN:1618-095X
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:BACKGROUND: Codonopsis lanceolata, a plant with antioxidant, anti-cancer, anti-inflammatory and blood lipid improving effects, has been widely used as a therapeutic agent in traditional medicine. PURPOSE: The present study investigated the ability of an ethanol extract of Codonopsis lanceolata (ECL) to prevent hypertension in hypertensive rats. METHODS: Rats were orally administered daily doses of 0 mg/kg, 200 mg/kg and 400 mg/kg ECL for 3 weeks. As a positive control, rats were orally administered 10 mg/kg/day nifedipine. Hypertension was induced by immobilization stress for 2 h/day and by administration of 0.8 mg/kg/day nicotine for 3 weeks, followed by injection of 3 mg/kg nicotine on the day of sacrifice. Blood pressure and heart rate were measured using a volume pressure recording system. Vasoconstriction and vasodilation of aortic cross sections were measured with a physiological recorder. Neutrophil counts in bronchoalveolar lavage fluid were estimated with an automated cell counter. RESULTS: Treatment with both dosages of ECL significantly reduced systolic blood pressure (SBP) in hypertensive rats. Both doses of ECL tended to increase ACh- and SNP-induced vascular relaxation in hypertensive rats. Treatment with 200 mg/kg ECL significantly reduced neutrophil in hypertensive rats. CONCLUSIONS: These results suggest that ECL is effective in reducing SBP and inflammation in hypertensive conditions.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[St] Status:In-Process

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[PMID]: 29376238
[Au] Autor:Tong YJ; Zhang HX; Chen YX; Dong ML; Ma K
[Ad] Address:Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
[Ti] Title:[Features of Professor Ma Kun's medication in treating ovulatory infertility].
[So] Source:Zhongguo Zhong Yao Za Zhi;42(23):4459-4463, 2017 Dec.
[Is] ISSN:1001-5302
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:In order to analyze Professor Ma Kun's medication in treating anovulatory infertility, her prescriptions for treating anovulatory infertility in 2012-2015 were collected. The medication features and the regularity of prescriptions were mined by using traditional Chinese medicine inheritance support system, association rules, complex system entropy clustering and other mining methods. Finally, a total of 684 prescriptions and 300 kinds of herbs were screened out, with a total frequency of 11 156 times; And 68 core combinations and 8 new prescriptions were mined. The top three frequently used herbs by effect were respectively tonic herb, blood circulation promoting herb, and Qi-circulation promoting herb. The top three tastes were sweetness, bitterness and pungent flavor. The results showed 28 herbs with a high frequency of ≥100.The top 10 frequently used herbs were respectively Angelica Sinensis Radix, Cyperi Rhizoma, Chuanxiong Rhizome, Paeoniae Radix Rubra, Cyathulae Radix, Taxilli Herba, Cuscutae Semen, Codonopsis Radix, Ligustri Lucidi Fructus, Paeoniae Albaand Paeoniae Radix Alba. The association rules analysis showed commonly used herbal pairs, including Rehmanniae Radix Preparata-Chuanxiong Rhizome, Rehmanniae Radix Preparata-Angelica Sinensis Radix, Cuscutae Semen-Dipsaci Radix. In conclusion, Professor Ma has treated anovulatory infertility by nourishing the kidney and activating blood throughout the treatment course, and attached the importance to the relationship between Qi and blood and there gulation of liver, spleen and kidney in treating anovulatory infertility.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180129
[Lr] Last revision date:180129
[Cl] Clinical Trial:ClinicalTrial
[St] Status:In-Data-Review
[do] DOI:10.19540/j.cnki.cjcmm.20171012.003

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[PMID]: 29337873
[Au] Autor:Qin FY; Cheng LZ; Yan YM; Liu BH; Cheng YX
[Ad] Address:State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. qinfuying@mail.kib.ac.cn.
[Ti] Title:Two Novel Proline-Containing Catechin Glucoside from Water-Soluble Extract of Codonopsis pilosula.
[So] Source:Molecules;23(1), 2018 Jan 16.
[Is] ISSN:1420-3049
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Choushenflavonoids A ( ) and B ( ), two unusual proline-containing catechin glucosides, were isolated from the roots of cultivated in a high-altitude location of Yunnan province. Their structures were determined by spectroscopic data and chemical methods. Specifically, the absolute configuration of glucose residue in and was assigned by acid hydrolysis followed by derivatization and gas chromatography (GC) analysis. In addition, biological evaluation of and against Sirtuin 1 (SIRT1) was carried out.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180116
[Lr] Last revision date:180116
[St] Status:In-Process

  8 / 311 MEDLINE  
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[PMID]: 29319339
[Au] Autor:Li XZ; Cheng LZ; Yan YM; Liu BH; Cheng YX
[Ad] Address:a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
[Ti] Title:SIRT1 inhibitory compounds from the roots of Codonopsis pilosula.
[So] Source:J Asian Nat Prod Res;:1-8, 2018 Jan 10.
[Is] ISSN:1477-2213
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Three new compounds, pilosulinene A (1), pilosulinols A (2), and B (3), along with seven known compounds, were isolated from the roots of Codonopsis pilosula cultivated in Xundian County of Yunnan Province. The structures of new compounds were established by spectroscopic methods. In particular, the presence of an aromatic ring in the structure of 1 makes it intriguing. The inhibitory activity of compounds against SIRT1 was evaluated. The results showed that 8 could inhibit Sirt1 in a dose-dependent manner.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180110
[Lr] Last revision date:180110
[St] Status:Publisher
[do] DOI:10.1080/10286020.2017.1422491

  9 / 311 MEDLINE  
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[PMID]: 29318837
[Au] Autor:Wu XJ; Zhang XB; Guo LP; Yu Y; Huang LQ
[Ad] Address:Department of Pharmacy, Zhejiang Chinese Medicine University, Hangzhou 310053, China.
[Ti] Title:[Study on distribution division of Codonopsis Radix].
[So] Source:Zhongguo Zhong Yao Za Zhi;42(22):4368-4372, 2017 Nov.
[Is] ISSN:1001-5302
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:This paper is aimed to clarify the distribution of Codonopsis Radix in China and search the main ecological factors that affect the suitability distribution. Through literature reading, National Specimen Information Infrastructure researching, field investigation and general survey of Chinese medicine resources, the distribution information was acquired. The MaxEnt model and ArcGIS technology were applied to analyze the main environmental factors influencing the suitability of Codonopsis Radix with integrated 55 environmental factors. The results showed the precipitation and altitude were the major factors impacting the ecology suitable of Codonopsis Radix. The ecological suitable region of C. pilosula was mainly concentrated in south Gansu, Shanxi, Shanxi, Ningxia and, and the ecological suitable region of C. pilosula var. modesta was mainly concentrated in south Gansu, northwest Guizhou, northeast Sichuan, and the ecological suitable region of C. tangshen was mainly concentrated in west Hubei, east Chongqing, middle Sichuan. Combined with the investigation and cultivation of Codonopsis Radix distribution information, the results of ecological suitability of Codonopsis Radix were verified. The ecological suitability distribution result of Codonopsis Radix was consistent with each species actual distribution, which could provide scientific basis for carrying out the rational cultivation of Codonopsis Radix.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180110
[Lr] Last revision date:180110
[St] Status:In-Data-Review
[do] DOI:10.19540/j.cnki.cjcmm.2017.0186

  10 / 311 MEDLINE  
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[PMID]: 29103497
[Au] Autor:Wu D; Cui L; Yang G; Ning X; Sun L; Zhou Y
[Ad] Address:Jilin Province Key Laboratory for Chemistry and Biology of Natural Drugs in Changbai Mountain, School of Life Sciences, Northeast Normal University, Changchun 130024, PR China.
[Ti] Title:Preparing rhamnogalacturonan II domains from seven plant pectins using Penicillium oxalicum degradation and their structural comparison.
[So] Source:Carbohydr Polym;180:209-215, 2018 Jan 15.
[Is] ISSN:1879-1344
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Rhamnogalacturonan II (RG-II) is a complex pectin with diverse pharmaceutical activities. To assess how RG-II functions, the development of methods for its preparation is required. In this paper, pectin from Codonopsis pilosula was used to evaluate the ability of fungi and bacteria to degrade the pectin. We discovered that the fungus Penicillium oxalicum could efficiently lead to the recovery of RG-II domains by degrading the other pectic domains. Further, six pectin fractions from different medical plants were used as the sole carbon source for the growth of Penicillium oxalicum. The major polymeric products remaining after fungus degradation was RG-II domains. Depending of plant source, side chains A differed with respect to their proportion of L-Gal and L-Fuc and to their degree of methyletherification. Side chains B were made of 8-10 sugar residues and up to 2 acetyl groups. Overall, our method provides an effective way to prepare RG-II pectin domains for investigating their structure-function relationships.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 180103
[Lr] Last revision date:180103
[St] Status:In-Process


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