Database : MEDLINE
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[PMID]: 29452147
[Au] Autor:Lin YK; Fang Z; Jiang TY; Wan ZH; Pan YF; Ma YH; Shi YY; Tan YX; Dong LW; Zhang YJ; Wang HY
[Ad] Address:International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, The Second Military Medical University, Shanghai, PR China.
[Ti] Title:Combination of Kras activation and PTEN deletion contributes to murine hepatopancreatic ductal malignancy.
[So] Source:Cancer Lett;421:161-169, 2018 Feb 13.
[Is] ISSN:1872-7980
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:Kras mutations are among the most common genetic abnormalities in human neoplasms, including cholangiocarcinomas, pancreatic cancer and colon cancer. PTEN has previously been associated with cholangiocarcinoma development in murine models. Here, we have established novel mouse models of neoplasms by liver-specific and biliary-pancreatic Kras activation and PTEN deletion. By liver-specific disruption of PTEN and activation of Kras in mice caused rapid development of intrahepatic biliary epithelial proliferative lesions (Intrahepatic cholangiocarcinoma, ICC), which progress through dysplasia to invasive carcinoma. In contrast, Kras activation in combination with heterozygous PTEN deletion induced mixed carcinomas of liver (both ICC and hepatocellular carcinoma, HCC), whereas Kras activation alone did not induce biliary tract neoplasm. Use of Sox9-Cre-LoxP-based approach to coordinately delete PTEN and activate Kras in the adult mouse resulted in not only development of low-grade biliary lesions (ICC and extrahepatic bile duct carcinoma, ECC) but also pancreatic carcinomas. Our data provide a functional link between PTEN gene status, hepatobiliary cell fate, and HCC, biliary carcinoma, pancreatic cancer pathogenesis, and present novel genetically engineered mouse models of PTEN loss-driven malignancy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher

  2 / 8608 MEDLINE  
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[PMID]: 29465591
[Au] Autor:Wang H; Lu SC; He L; Dong JH
[Ad] Address:Department of Hepatobiliary Surgery, The General Hospital of the People's Liberation army.
[Ti] Title:A study on risk factors and diagnostic efficiency of posthepatectomy liver failure in the nonobstructive jaundice.
[So] Source:Medicine (Baltimore);97(8):e9963, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Liver failure remains as the most common complication and cause of death after hepatectomy, and continues to be a challenge for doctors.t test and χ test were used for single factor analysis of data-related variables, then results were introduced into the model to undergo the multiple factors logistic regression analysis. Pearson correlation analysis was performed for related postoperative indexes, and a diagnostic evaluation was performed using the receiver operating characteristic (ROC) of postoperative indexes.Differences in age, body mass index (BMI), portal vein hypertension, bile duct cancer, total bilirubin, alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), operation time, cumulative portal vein occlusion time, intraoperative blood volume, residual liver volume (RLV)/entire live rvolume, ascites volume at postoperative day (POD)3, supplemental albumin amount at POD3, hospitalization time after operation, and the prothrombin activity (PTA) were statistically significant. Furthermore, there were significant differences in total bilirubin and the supplemental albumin amount at POD3. ROC analysis of the average PTA, albumin amounts, ascites volume at POD3, and their combined diagnosis were performed, which had diagnostic value for postoperative liver failure (area under the curve (AUC): 0.895, AUC: 0.798, AUC: 0.775, and AUC: 0.903).Preoperative total bilirubin level and the supplemental albumin amount at POD3 were independent risk factors. PTA can be used as the index of postoperative liver failure, and the combined diagnosis of the indexes can improve the early prediction of postoperative liver failure.
[Mh] MeSH terms primary: Hepatectomy/adverse effects
Jaundice/blood
Liver Failure/etiology
Postoperative Complications
[Mh] MeSH terms secundary: Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Area Under Curve
Ascites/etiology
Bilirubin/blood
Body Mass Index
Chi-Square Distribution
Child
Child, Preschool
Female
Humans
Hypertension, Portal/complications
Hypertension, Portal/surgery
Infant
Jaundice/surgery
Liver Function Tests
Liver Neoplasms/complications
Liver Neoplasms/surgery
Logistic Models
Male
Middle Aged
Operative Time
Postoperative Period
Predictive Value of Tests
Preoperative Period
Prothrombin Time
ROC Curve
Retrospective Studies
Risk Factors
Serum Albumin/analysis
Young Adult
[Pt] Publication type:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Name of substance:0 (Serum Albumin); RFM9X3LJ49 (Bilirubin)
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009963

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[PMID]: 29465585
[Au] Autor:Zhang C; Zhou J; Kou K; Liu S; We F; Wang G
[Ad] Address:First Hospital of Jilin University, Changchun, Jilin, China.
[Ti] Title:Occurrence of signet-ring cell carcinoma with cholangiocarcinoma 25 years after choledochal cyst excision: A case report.
[So] Source:Medicine (Baltimore);97(8):e9956, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Choledochal cysts are a risk factor for the development of cholangiocarcinoma. Hence, complete surgical excision is the preferred treatment in most cases. However, cholangiocarcinoma still can develop from the remnant biliary system after surgical excision. Signet-ring cell carcinoma is a rare type of cancer of the biliary system, and the occurrence of signet-ring cell carcinoma after surgical excision of choledochal cysts has not been reported in the English literature to date. PATIENT CONCERNS: We report a case of a 32-year-old woman who presented with a 1-month history of abdominal pain,obstructive jaundice, itching, and fever. The patient had undergone choledochal cyst excision and Roux-en-Y hepatico-jejunostomy 25 years previously and had now developed signet-ring cell carcinoma along with cholangiocarcinoma at the anastomotic site. DIAGNOSES:: signet-ring cell carcinoma along with cholangiocarcinoma. INTERVENTIONS: Interventions included laparotomy with evacuation,blood transfusion,and other adjuvant therapy. OUTCOMES: The patient died five months later. LESSONS: Surgery is the best treatment for CCCs, and the surgeon should try to remove as much as of the bile duct cyst as possible.
[Mh] MeSH terms primary: Bile Duct Neoplasms/etiology
Biliary Tract Surgical Procedures/adverse effects
Carcinoma, Signet Ring Cell/etiology
Cholangiocarcinoma/etiology
Choledochal Cyst/surgery
Postoperative Complications/etiology
[Mh] MeSH terms secundary: Adult
Anastomosis, Roux-en-Y/adverse effects
Female
Humans
Jejunum/surgery
Liver/surgery
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009956

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[PMID]: 29272078
[Au] Autor:Nakanuma Y; Jang KT; Fukushima N; Furukawa T; Hong SM; Kim H; Lee KB; Zen Y; Jang JY; Kubota K
[Ad] Address:Department of Diagnostic Pathology, Shizuoka Cancer Center, Sunto-Nagaizumi 1007, Shizuoka 411-8777, Japan.
[Ti] Title:A statement by the Japan-Korea expert pathologists for future clinicopathological and molecular analyses toward consensus building of intraductal papillary neoplasm of the bile duct through several opinions at the present stage.
[So] Source:J Hepatobiliary Pancreat Sci;, 2017 Dec 22.
[Is] ISSN:1868-6982
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:Intraductal papillary neoplasm of bile duct (IPNB) was described as a preinvasive neoplastic lesion of the biliary tract in the 2010 World Health Organization (WHO) classification. Although a number of studies have since been conducted on IPNBs, controversy remains, particularly regarding the standardization of its definition. Meetings by Japanese and Korean expert pathologists were held twice to resolve the pathological diagnostic aspects of IPNB. Through round-table discussions and histological reviews, we reached the common understanding that IPNBs diagnosed according to the criteria of WHO 2010 are characterized by intraductal predominant papillary or villous biliary neoplasms covering delicate fibrovascular stalks and are classified into two types pathologically. One type (type 1 IPNB) is histologically similar to intraductal papillary mucinous neoplasms of pancreas, and typically develops in the intrahepatic bile ducts, while the other (type 2 IPNB) has a more complex histological architecture with irregular papillary branching or with foci of solid-tubular components and typically involves the extrahepatic bile ducts. This report states the diagnostic pathologic features of IPNB proposed by WHO 2010. Since currently, the concept of IPNB is still confusing, the proposed diagnostic pathologic features stated here will be of use for future clinicopathological and molecular analyses toward consensus building of IPNB.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[St] Status:Publisher
[do] DOI:10.1002/jhbp.532

  5 / 8608 MEDLINE  
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[PMID]: 28470686
[Au] Autor:Sideras K; Biermann K; Yap K; Mancham S; Boor PPC; Hansen BE; Stoop HJA; Peppelenbosch MP; van Eijck CH; Sleijfer S; Kwekkeboom J; Bruno MJ
[Ad] Address:Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
[Ti] Title:Tumor cell expression of immune inhibitory molecules and tumor-infiltrating lymphocyte count predict cancer-specific survival in pancreatic and ampullary cancer.
[So] Source:Int J Cancer;141(3):572-582, 2017 08 01.
[Is] ISSN:1097-0215
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Understanding the mechanisms of immune resistance in pancreatic and ampullary cancers is crucial for the development of suitable biomarkers and effective immunotherapeutics. Our aim was to examine the expression of the immune inhibiting molecules PD-L1, Galectin-9, HVEM, IDO and HLA-G, as well as CD8+ and FoxP3+ tumor infiltrating lymphocytes (TIL), in pancreatic and ampullary cancers, and to relate their individual, as well as their combined expression, to cancer survival. Tumor tissue from 224 patients with resected pancreatic (n = 148) and ampullary (n = 76) cancer was used to construct tissue-microarrays. Expression of immune inhibitory molecules and TIL was examined by immunohistochemistry. We show that immune inhibitory molecules are prevalently expressed. Moreover, high tumor expression of PD-L1 (p = 0.002), Gal-9 (p = 0.003), HVEM (p = 0.001), IDO (p = 0.049), HLA-G (p = 0.004) and high CD8/FoxP3 TIL ratio (p = 0.006) were associated with improved cancer-specific survival. All immune biomarkers, with the exception of IDO, were individually predictive of cancer-specific survival when adjusted for clinicopathologic characteristics. For every additional immune biomarker present survival was almost two-fold prolonged (HR 0.57 95%CI 0.47-0.69, p < 0.0001). When patients with pancreatic and ampullary cancer were analyzed separately the results were similar. We conclude that pancreas and ampullary cancers are rich in expression of immune-inhibitory molecules. These molecules can be targets for future immunotherapeutics, as well as form powerful immunological biomarkers. We propose that such immune biomarker panels be included in future prospective immunotherapy trials.
[Mh] MeSH terms primary: B7-H1 Antigen/metabolism
Common Bile Duct Neoplasms/mortality
Galanin/metabolism
HLA-G Antigens/metabolism
Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism
Lymphocytes, Tumor-Infiltrating/immunology
Pancreatic Neoplasms/mortality
Receptors, Tumor Necrosis Factor, Member 14/metabolism
[Mh] MeSH terms secundary: Adult
Aged
Aged, 80 and over
Ampulla of Vater/immunology
Ampulla of Vater/metabolism
Biomarkers, Tumor/metabolism
Common Bile Duct Neoplasms/immunology
Common Bile Duct Neoplasms/metabolism
Female
Humans
Lymphocytes, Tumor-Infiltrating/metabolism
Lymphocytes, Tumor-Infiltrating/pathology
Male
Middle Aged
Pancreatic Neoplasms/immunology
Pancreatic Neoplasms/metabolism
Prognosis
Retrospective Studies
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (B7-H1 Antigen); 0 (Biomarkers, Tumor); 0 (CD274 protein, human); 0 (GAL protein, human); 0 (HLA-G Antigens); 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase); 0 (Receptors, Tumor Necrosis Factor, Member 14); 0 (TNFRSF14 protein, human); 88813-36-9 (Galanin)
[Em] Entry month:1710
[Cu] Class update date: 180208
[Lr] Last revision date:180208
[Js] Journal subset:IM
[Da] Date of entry for processing:170505
[St] Status:MEDLINE
[do] DOI:10.1002/ijc.30760

  6 / 8608 MEDLINE  
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[PMID]: 29317591
[Au] Autor:Tasch JJ; Dube N
[Ad] Address:Graduate Medical Education, Camden Clark Medical Center, Parkersburg, WV, USA.
[Ti] Title:An Unusual Presentation of Advanced Intrahepatic Cholangiocarcinoma: When Biopsy Results Fail.
[So] Source:Am J Case Rep;19:35-40, 2018 Jan 10.
[Is] ISSN:1941-5923
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND Intrahepatic cholangiocarcinoma is a rare condition which typically occurs in males between 50 and 70 years of age, and presents with symptoms related to biliary obstruction including jaundice, pruritus, and dark urine. Other common symptoms at presentation include abdominal pain, weight loss, and fever. CASE REPORT We present a case of a 67-year-old female initially presenting with chest pain at rest, found to have a lung nodule on diagnostic imaging at the time of admission. On further imaging, a 9 cm liver lesion was incidentally discovered, initially suspicious for hepatocellular carcinoma on imaging, with initial biopsy staining CK7 positive, and CK20 negative. The patient also had an elevated alpha-fetoprotein level. Biopsy results were later confirmed as moderately differentiated adenocarcinoma consistent with intrahepatic cholangiocarcinoma. CONCLUSIONS This report illustrates an unusual presentation of intrahepatic cholangiocarcinoma. Although rare, cholangiocarcinoma is diagnosed most frequently as an incidental finding on imaging studies. With quick work-up and successful biopsy results, patients can undergo surgical or chemo-radiation therapy earlier, potentially leading to a longer survival time.
[Mh] MeSH terms primary: Bile Duct Neoplasms/diagnosis
Biomarkers, Tumor/blood
Cholangiocarcinoma/diagnosis
alpha-Fetoproteins/metabolism
[Mh] MeSH terms secundary: Aged
Bile Duct Neoplasms/blood
Bile Ducts, Intrahepatic/pathology
Biopsy
Cholangiocarcinoma/blood
Diagnosis, Differential
Female
Humans
Incidental Findings
Neoplasm Staging
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Biomarkers, Tumor); 0 (alpha-Fetoproteins)
[Em] Entry month:1802
[Cu] Class update date: 180205
[Lr] Last revision date:180205
[Js] Journal subset:IM
[Da] Date of entry for processing:180111
[St] Status:MEDLINE

  7 / 8608 MEDLINE  
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[PMID]: 28461144
[Au] Autor:Bourgouin S; Ewald J; Mancini J; Moutardier V; Delpero JR; Le Treut YP
[Ad] Address:Aix-Marseille University, APHM La Conception, Department of Surgery and Liver Transplantation, Marseille, France; Sainte Anne Military Teaching Hospital, Department of Oncologic and Digestive Surgery, Toulon, France. Electronic address: stephane_bourgouin@hotmail.fr.
[Ti] Title:Disease-free survival following resection in non-ductal periampullary cancers: A retrospective multicenter analysis.
[So] Source:Int J Surg;42:103-109, 2017 Jun.
[Is] ISSN:1743-9159
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Predictors of recurrence following pancreaticoduodenectomy are well described for ductal periampullary cancers but lack reliability for non-ductal tumors. The purpose of this study is to analyze the disease-free survival (DFS) and to define the predictors of recurrence following resection for ampullary (AC), bile duct (BDC) and duodenal cancers (DC). MATERIALS AND METHODS: Clinico-pathological data of patients operated on between 2001 and 2011 were retrospectively reviewed. The effect of lymphatic invasion was specified using the lymph node ratio (LNR) and the number of positive nodes (NPN), with thresholds calculated with the likelihood ratio. Kaplan-Meier disease-free survival (DFS) curves were compared for all covariates by a log-rank test. Multivariate logistic regression analyses were performed to identify predictors of recurrence. RESULTS: 135 patients were identified. Mean follow-up was 49 ± 35 months. Median DFS was not reached for AC and was 36 and 18 months for DC and BDC, respectively. Five-year DFS was 52%, 43% and 32% for AC, DC and BDC, respectively. Predictors of recurrence were T4 tumors, neural invasion and preoperative biliary drainage for DC, ≥3 positive nodes and ≥4% loss of BMI for AC, and T3-T4 tumors for BDC. CONCLUSION: Loss of BMI ≥4% is a strong predictor of recurrence in AC, and the recurrence risk increases with the total number of lymph nodes invaded (0; 1-3; ≥4). Only T stage influences recurrence for BDC. Considering DC, the adverse effect of preoperative biliary drainage should be validated in randomized series.
[Mh] MeSH terms primary: Ampulla of Vater
Common Bile Duct Neoplasms/surgery
Duodenal Neoplasms/surgery
Pancreaticoduodenectomy
[Mh] MeSH terms secundary: Adult
Aged
Aged, 80 and over
Ampulla of Vater/surgery
Common Bile Duct Neoplasms/mortality
Common Bile Duct Neoplasms/pathology
Disease-Free Survival
Duodenal Neoplasms/mortality
Duodenal Neoplasms/pathology
Female
Humans
Male
Middle Aged
Retrospective Studies
[Pt] Publication type:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Entry month:1801
[Cu] Class update date: 180131
[Lr] Last revision date:180131
[Js] Journal subset:IM
[Da] Date of entry for processing:170503
[St] Status:MEDLINE

  8 / 8608 MEDLINE  
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[PMID]: 29310402
[Au] Autor:Ye Z; Ye S; Zhou D; Zheng S; Wang W
[Ad] Address:Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital.
[Ti] Title:A rare variation of celiac trunk and hepatic artery complicating pancreaticoduodenectomy: A case report and literature review.
[So] Source:Medicine (Baltimore);96(48):e8969, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Anatomical variations of the celiac trunk and the hepatic artery are of considerable importance in hepatopancreatobiliary surgery, liver transplants, and radiological abdominal interventions. PATIENT CONCERNS: Here, we report a 57-year-old man with 2 weeks of painless progressive jaundice. Preoperative imaging and cytology brush results suggested an ampullary tumor and common hepatic artery anomaly (CTA) was reported. The patient underwent pancreaticoduodenectomy (PD). Intraoperatively, the CHA and gastroduodenal artery (GDA) were abnormal. The CHA emerged from the superior mesenteric artery (SMA). Computer tomography angiography (CTA) was performed postoperatively; surprisingly, the left gastric artery (LGA) and splenic artery (SA) arising from the anterior wall of the abdominal aorta replaced the normal structure of the celiac trunk, and an accessory left hepatic artery (LHA) emerged from the LGA. DIAGNOSES: The patient was diagnosed with cholangiocarcinoma and accompanying extremely rare variation of celiac trunk and hepatic artery. INTERVENTIONS AND OUTCOMES: The patient underwent PD and had an uneventful postoperative evolution. There was no recurrence of the tumor and with normal liver function during the 10-month follow-up. INTERVENTIONS: The patient underwent PD and had an uneventful postoperative evolution. OUTCOMES: There was no recurrence of the tumor and with normal liver function during the 10-month follow-up. LESSONS: Surgeons must keep in mind that arterial variation may be present in the vascular structures intraoperatively, even if it was not revealed in preoperative imaging. The preoperative identification of arterial variation and its relationship with the tumor is necessary to avoid intraoperative vascular injury and complications after surgery.
[Mh] MeSH terms primary: Anatomic Variation
Bile Duct Neoplasms/surgery
Celiac Artery
Cholangiocarcinoma/surgery
Hepatic Artery
Pancreaticoduodenectomy
[Mh] MeSH terms secundary: Bile Duct Neoplasms/complications
Bile Duct Neoplasms/diagnostic imaging
Celiac Artery/diagnostic imaging
Celiac Artery/surgery
Cholangiocarcinoma/complications
Cholangiocarcinoma/diagnostic imaging
Diagnosis, Differential
Hepatic Artery/diagnostic imaging
Hepatic Artery/surgery
Humans
Jaundice/diagnostic imaging
Jaundice/etiology
Jaundice/surgery
Male
Middle Aged
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1801
[Cu] Class update date: 180116
[Lr] Last revision date:180116
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180110
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008969

  9 / 8608 MEDLINE  
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[PMID]: 29307199
[Au] Autor:Mostafa ME; Erbarut-Seven I; Pehlivanoglu B; Adsay V
[Ad] Address:Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA.
[Ti] Title:Pathologic classification of "pancreatic cancers": current concepts and challenges.
[So] Source:Chin Clin Oncol;6(6):59, 2017 Dec.
[Is] ISSN:2304-3873
[Cp] Country of publication:China
[La] Language:eng
[Ab] Abstract:As the most common and most important cancer of the pancreas, with rapid mortality and now also as the third leading cause of cancer-related deaths in the United States, pancreatic ductal adenocarcinoma (PDAC) has become synonymous with "pancreas cancer". PDAC is also the prototype of the "pancreatobiliary-type" adenocarcinomas, along the biliary tract, ampullary and gallbladder cancers with the similar morphology and behavior. Recent molecular profiling studies have identified distinct subsets of PDAC, potentially with different behaviors and targetability. Moreover, while PDAC is by far the most common cancer of the pancreas, there are various other types that occur in this organ and are erroneously classified together with PDAC. Many of these have different molecular and biologic characteristics that warrant their management separately although they are also technically "pancreatic cancers". While some are closely related to PDAC and have as aggressive behavior (such as adenosquamous carcinomas which are recently recognized under "basal" like category in profiling studies, which are actually even worse prognostically than PDACs), in the meantime, others such as colloid carcinoma has a much better behavior than PDAC, and as a carcinoma with intestinal lineage (MUC2/CDX2) colloid carcinoma may require an entirely different treatment approach as well. Similarly, medullary carcinomas also appear to have different biology. Additionally, non-ductal cancers such as acinar, neuroendocrine, solid-pseudopapillary neoplasms and pancreatoblastoma have their respective clinicopathologic and molecular associations and warrant careful elimination in the management and study protocols. Another very problematic aspect in the classification of "pancreas cancer" is its delineation from the cancers of neighboring organs, in particular, ampullary/duodenal and common bile duct (CBD) cancers, for which recently more refined criteria have been provided. Additionally, the possibility of metastasis from another site and lymphomas also need to be considered. In summary, there is a whole host of cancers that occur in the pancreas that ought to be considered carefully before a case is classified as an ordinary "pancreas cancer" (PDAC).
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180108
[Lr] Last revision date:180108
[St] Status:In-Process
[do] DOI:10.21037/cco.2017.12.01

  10 / 8608 MEDLINE  
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[PMID]: 28458597
[Au] Autor:Park HJ; Kim HJ; Park SH; Lee JS; Kim AY; Ha HK
[Ad] Address:Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea.
[Ti] Title:Gastrointestinal Involvement of Recurrent Renal Cell Carcinoma: CT Findings and Clinicopathologic Features.
[So] Source:Korean J Radiol;18(3):452-460, 2017 May-Jun.
[Is] ISSN:2005-8330
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To retrospectively evaluate the CT findings and clinicopathologic features in patients with gastrointestinal (GI) involvement of recurrent renal cell carcinoma (RCC). MATERIALS AND METHODS: The medical records were reviewed for 15 patients with 19 pathologically proven GI tract metastases of RCC. The CT findings were analyzed to determine the involved sites and type of involvement; lesion size, morphology, and contrast enhancement pattern; and occurrence of lymphadenopathy, ascites and other complications. RESULTS: The most common presentation was GI bleeding (66.7%). The average interval between nephrectomy and the detection of GI involvement was 30.4 ± 37.4 months. GI lesions were most commonly found in the ileum (36.8%) and duodenum (31.6%). A distant metastasis (80%) was more common than a direct invasion from metastatic lesions. The mean lesion size was 34.1 ± 15.0 mm. Intraluminal polypoid masses (63.2%) with hyperenhancement (78.9%) and heterogeneous enhancement (63.2%) were the most common findings. No patients had regional lymphadenopathy. Complications occurred in four patients, with one each of bowel obstruction, intussusception, bile duct dilatation, and pancreatic duct dilatation. CONCLUSION: GI involvement of recurrent RCC could be included in the differential diagnosis of patients with heterogeneous, hyperenhanced intraluminal polypoid masses in the small bowel on CT scans along with a relative paucity of lymphadenopathy.
[Mh] MeSH terms primary: Carcinoma, Renal Cell/diagnostic imaging
Tomography, X-Ray Computed
[Mh] MeSH terms secundary: Adult
Aged
Aged, 80 and over
Carcinoma, Renal Cell/pathology
Diagnosis, Differential
Female
Gastrointestinal Hemorrhage/diagnostic imaging
Gastrointestinal Hemorrhage/pathology
Gastrointestinal Neoplasms/diagnostic imaging
Gastrointestinal Neoplasms/secondary
Humans
Intussusception/diagnostic imaging
Lymphatic Diseases
Male
Middle Aged
Neoplasm Recurrence, Local
Neoplasm Staging
Nephrectomy
Retrospective Studies
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 180102
[Lr] Last revision date:180102
[Js] Journal subset:IM
[Da] Date of entry for processing:170502
[St] Status:MEDLINE
[do] DOI:10.3348/kjr.2017.18.3.452


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