Database : MEDLINE
Search on : Condylomata and Acuminata [Words]
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[PMID]: 29489693
[Au] Autor:Guo X; Wu X; Guo A; Zhao Y
[Ad] Address:Nursing Department, Peking Union Medical College Hospital.
[Ti] Title:Reliability and validity of the Chinese CECA10 questionnaire for Chinese patients with condyloma acuminata.
[So] Source:Medicine (Baltimore);97(9):e9917, 2018 Mar.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Condyloma acuminata (CA) is a sexually transmitted disease that affects quality of life (QOL). CECA10 is an English-language questionnaire for assessing QOL in patients with CA, but there is no equivalent in China. This study aimed to develop a validated and reliable Chinese version of CECA10.The Chinese CECA10 was developed from the English version by forward translation, back translation, comparison with the original, cultural adjustments, and a pre-test (5 patients). The Chinese CECA10 and EuroQol Five Dimensions Three Level Questionnaire (EQ-5D-3L) was administered to patients with CA. Content validity (item/scale content validity indexes, I-CVI/S-CVI), test-retest reliability (intraclass coefficient, ICC), internal consistency (Cronbach α), criterion validity (comparison with the Dermatology Life Quality Index, DLQL, using Spearman correlation analysis), construct validity (exploratory factor analysis), and discriminant validity (between subgroups based on number of warts, number of recurrences, or number of sites involved) were assessed.The Chinese CECA10 had good test-retest reliability (ICC = 0.98, P < .001), internal consistency (Cronbach α values of 0.88, 0.84, and 0.83 for the total questionnaire, psychological dimension, and sexual dimension, respectively), content validity (I-CVI = 1 for all items), and criterion validity (r = -0.50, P < .001). Exploratory factor analysis extracted 2 factors with a cumulative contribution of 61.75%; the factor loading with each item was >0.4. Discriminant validity was not high. The mean CECA10 and EQ-VAS scores of 211 patients with CA (28.19  7.16 years; 139 males) were 34.56  19.01 and 64.64  19.28, respectively.The Chinese CECA10 has good reliability and validity for evaluating the QOL of Chinese patients with CA.
[Mh] MeSH terms primary: Asian Continental Ancestry Group/psychology
Condylomata Acuminata/psychology
Quality of Life
Surveys and Questionnaires/standards
[Mh] MeSH terms secundary: Adolescent
Adult
China
Cross-Sectional Studies
Factor Analysis, Statistical
Female
Humans
Language
Male
Middle Aged
Reproducibility of Results
Translations
Young Adult
[Pt] Publication type:JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180301
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009917

  2 / 5051 MEDLINE  
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[PMID]: 29513235
[Au] Autor:Carmona Lorduy M; Harris Ricardo J; Hernndez Arenas Y; Medina Carmona W
[Ti] Title:Use of trichloroacetic acid for management of oral lesions caused by human papillomavirus.
[So] Source:Gen Dent;66(2):47-49, 2018 Mar-Apr.
[Is] ISSN:0363-6771
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The human papillomavirus (HPV) has an affinity for squamous cells of stratified keratinized epithelium, thus affecting the lower genital, nasal, and oral tracts. In the oral cavity, HPV is associated with pathoses such as the verruca vulgaris (common wart), squamous cell papilloma, condyloma acuminatum (venereal wart), and focal epithelial hyperplasia (Heck disease). Among the treatments available for these lesions are cryotherapy, electrosurgery, surgical removal, laser therapy, and trichloroacetic acid (TCA). The objective of this research was to determine the behavior of HPV-associated oral pathoses treated with TCA. A prospective cohort study was performed in 20 patients who attended a dental consultation at 2 universities in Cartagena, Colombia. Among the patients, 65% were diagnosed as having focal epithelial hyperplasia, 20% as having verrucae vulgares, and 15% as having condylomata acuminata. Application of TCA to HPV-associated oral lesions proved to be a useful nonsurgical alternative treatment, as the resolution of the lesions was achieved atraumatically in a span of 45 days with 3 applications of 30-60 seconds each.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Data-Review

  3 / 5051 MEDLINE  
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[PMID]: 29239064
[Au] Autor:Masuda M; Abiko K; Minamiguchi S; Murakami R; Baba T; Konishi I
[Ad] Address:Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
[Ti] Title:Case of rapidly progressing condylomatous squamous cell carcinoma of the uterine cervix associated with low-risk human papillomavirus type 6.
[So] Source:J Obstet Gynaecol Res;44(3):583-587, 2018 Mar.
[Is] ISSN:1447-0756
[Cp] Country of publication:Australia
[La] Language:eng
[Ab] Abstract:Condylomatous, or warty squamous cell carcinoma (SCC) of the uterine cervix, is a rare variant of invasive SCC. Here, we describe a case of aggressive condylomatous SCC of the uterine cervix. A 43-year-old woman was monitored for 3 years for suspected low-grade squamous intraepithelial lesion. A whitish papillary mass occupied the cervix, and the colposcopic diagnosis was condyloma acuminatum. A cervical biopsy revealed papillary proliferating thick squamous epithelium, which consisted of koilocytes and atypical cells with enlarged nuclei. Hysterectomy specimens showed a thick layer of atypical squamous epithelium with koilocytosis invading the stroma. Immunohistochemistry revealed negative p16 expression. Hysterectomy specimens tested positive for low-risk human papillomavirus type 6, but negative for other high-risk human papillomavirus types. The bilateral pelvic and para-aortic lymph nodes were positive for metastases. In spite of adjuvant chemotherapy, the case relapsed with multiple lymph nodes and lung metastases shortly after the operation.
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1712
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process
[do] DOI:10.1111/jog.13553

  4 / 5051 MEDLINE  
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[PMID]: 29186268
[Au] Autor:Camargo CC; D'Elia MPB; Miot HA
[Ad] Address:Department of Tropical Disesases and Imagery Diagnostics, Botucatu School of Medicine, Universidade Estadual Paulista "Jlio de Mesquita Filho" (FMB-Unesp) - Botucatu (SP) Brazil.
[Ti] Title:Quality of life in men diagnosed with anogenital warts.
[So] Source:An Bras Dermatol;92(3):427-429, 2017 May-Jun.
[Is] ISSN:1806-4841
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:Anogenital warts are a worldwide public health problem. They consist of epithelial proliferations caused by HPV, whose transmission occurs mainly through sexual intercourse. In this study, we evaluated their impact on the quality of life of adult males. We interviewed 88 men in an outpatient clinic for sexually transmitted diseases at a Brazilian public institution, using the DLQI-BRA questionnaire. Most patients (81%) presented mild or no impairment of quality of life. The main dimensions affected were sex life, symptoms, and embarrassment. The low impact on quality of life may well justify the delay in seeking medical treatment, favoring the spread of the disease.
[Mh] MeSH terms primary: Anus Diseases/psychology
Condylomata Acuminata/psychology
Quality of Life/psychology
[Mh] MeSH terms secundary: Adult
Ambulatory Care Facilities
Humans
Male
Socioeconomic Factors
Surveys and Questionnaires
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180131
[Lr] Last revision date:180131
[Js] Journal subset:IM
[Da] Date of entry for processing:171130
[St] Status:MEDLINE

  5 / 5051 MEDLINE  
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[PMID]: 29255542
[Au] Autor:Naciri I; Ismaili N
[Ad] Address:Service de Dermatologie et Vnrologie, Centre Hospitalier Universitaire IBN Sina, Facult de Mdecine et de Pharmacie, Universit Mohammed V, Rabat, Maroc.
[Ti] Title:Kratoses sborrhiques gantes de sige inhabituel. [Unusual location of giant seborrhoeic keratoses].
[So] Source:Pan Afr Med J;28:72, 2017.
[Is] ISSN:1937-8688
[Cp] Country of publication:Uganda
[La] Language:fre
[Ab] Abstract:Seborrhoeic keratoses (SK) are benign tumors that mainly occur in the head and in the trunk. Their size generally varies from a few millimeters up to a few centimeters. Giant lesions are very rare but pose a problem in terms both of treatment and transformation. Their occurrence in the genital area is even more rare, posing a problem in differential diagnosis of genital warts. Differentiation is only based on histopathology. We report the case of a 80-year old man, with no particular past medical history, who presented with asymptomatic abdominal and genital lesions evolving over the last twenty years. Clinical examination showed four hyperpigmented, humped, well-defined tumors, with warty surface measuring 2-10 cm along its longer axis (A). Dermoscopic examination showed cerebriform convolutions appearance suggesting seborrhoeic keratoses (B). Histology confirmed the diagnosis, without signs of viral infection or malignant transformation. The patient underwent surgical resection resulting in permanent scar.
[Mh] MeSH terms primary: Condylomata Acuminata/diagnosis
Dermoscopy/methods
Genital Diseases, Male/diagnosis
Keratosis, Seborrheic/diagnosis
[Mh] MeSH terms secundary: Aged, 80 and over
Condylomata Acuminata/surgery
Diagnosis, Differential
Genital Diseases, Male/pathology
Genital Diseases, Male/surgery
Humans
Keratosis, Seborrheic/surgery
Male
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171222
[Lr] Last revision date:171222
[Js] Journal subset:IM
[Da] Date of entry for processing:171220
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.28.72.13766

  6 / 5051 MEDLINE  
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[PMID]: 29161070
[Au] Autor:Flagg EW; Torrone EA
[Ad] Address:Both authors are with the Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
[Ti] Title:Declines in Anogenital Warts Among Age Groups Most Likely to Be Impacted by Human Papillomavirus Vaccination, United States, 2006-2014.
[So] Source:Am J Public Health;:e1-e8, 2017 Nov 21.
[Is] ISSN:1541-0048
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVES: To detect decreases in anogenital warts (AGW) among sex and age groups likely to be affected by human papillomavirus vaccination. METHODS: We estimated annual AGW prevalence during 2006 to 2014 using health care claims among US private health insurance enrollees aged 15 to 39 years. We derived AGW diagnoses using 1 of the following: (1) condylomata acuminata diagnosis, (2) viral wart diagnosis combined with a benign anogenital neoplasm diagnosis or destruction or excision of an anogenital lesion, or (3) AGW medication combined with a benign anogenital neoplasm diagnosis or destruction or excision of an anogenital lesion. RESULTS: Prevalence decreased during 2008 to 2014 among females aged 15 to 19 years (annual percentage change [APC] = -14.1%; P < .001) and during 2009 to 2014 among women aged 20 to 24 years (APC = -12.9%; P < .001) and among women aged 25 to 29 years (APC = -6.0%; P = .001). We observed significant declines among men aged 20 to 24 years (APC = -6.5%; P = .005). Prevalence increased or was stable in all other sex and age groups. CONCLUSIONS: We observed AGW decreases among females in the age groups most likely to be affected by human papillomavirus vaccination and decreases in men aged 20 to 24 years. Decreased prevalence in young men is likely attributable to herd protection from vaccination among females. (Am J Public Health. Published online ahead of print November 21, 2017: e1-e8. doi:10.2105/AJPH.2017.304119).
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171121
[Lr] Last revision date:171121
[St] Status:Publisher
[do] DOI:10.2105/AJPH.2017.304119

  7 / 5051 MEDLINE  
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[PMID]: 29154519
[Au] Autor:Mistrangelo M; Dal Conte I; Volpatto S; DI Benedetto G; Testa V; Currado F; Morino M
[Ad] Address:Department of Surgical Sciences, University of Torino, Citt della Salute e della Scienza di Torino, Turin, Italy - mistrangelo@katamail.com.
[Ti] Title:Current treatments for anal condylomata acuminata.
[So] Source:Minerva Chir;, 2017 Nov 20.
[Is] ISSN:1827-1626
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Condylomata acuminate are the most common sexually transmitted disease worldwide. They are usually a serious problem, but it causes emotional distress to patient and physician alike because of its marked tendency to recurrence. The presence of anogenital warts mandates treatment, also for potential degeneration of the lesions. EVIDENCE ACQUISITION: A review of the Literature has been performed to analyze proposed treatments for anogenital warts. EVIDENCE SYNTHESIS: Many treatments have been employed. They include cytotoxic agents, immunomodulation and physical ablation. The choice of the appropriate treatment varies depending on the number, size, and location of warts. Complications of various treatments are rare but include permanent depigmentation, itching, pain, scarring, bleeding, anal stenosis or incontinence and sepsis. The therapy of these lesions can sometimes be very painful and expensive, and therapy should not be worse than the disease. CONCLUSIONS: No specific antiviral treatment is available and no consensus has been reached on the appropriate treatment for anogenital warts. No data are available to indicate whether treatment eliminates infectivity, the primary aim of treatment being to remove the lesions. There is a paucity of published randomized trials. Despite the introduction of antiviral treatments such as interferon or imiquimod, surgical destruction or removal remains the treatment of choice.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171120
[Lr] Last revision date:171120
[St] Status:Publisher
[do] DOI:10.23736/S0026-4733.17.07554-X

  8 / 5051 MEDLINE  
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[PMID]: 29100527
[Au] Autor:Wang Y; Li X; Song S; Sun Y; Zhang J; Yu C; Chen W
[Ad] Address:Department of Pharmacology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 12 Jiang Wang Miao Street, Nanjing, 210042, China.
[Ti] Title:HPV11 E6 mutation by overexpression of APOBEC3A and effects of interferon-ω on APOBEC3s and HPV11 E6 expression in HPV11.HaCaT cells.
[So] Source:Virol J;14(1):211, 2017 Nov 03.
[Is] ISSN:1743-422X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Condyloma acuminatum, infected by low-risk human papillomaviruses (e.g., HPV6 and HPV11), is one of the most widespread sexually transmitted diseases. Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 proteins (APOBEC3s, A3s) are cellular cytidine deaminases acting as antiviral factors through hypermutation of viral genome. However, it remains unknown whether A3s results in HPV11 gene mutations and interferon-ω (IFN-ω) exhibits antiviral activities through the A3s system. Here we investigated whether enhanced APOBEC3A (A3A) resulted in the E6 gene mutations and explore the effects of recombinant human interferon-ω (rhIFN-ω) on A3s/E6 expression in HaCaT keratinocytes containing the genome of HPV 11 (HPV11.HaCaT cells). METHODS: A3A-overexpressed HPV11.HaCaT (A3A-HPV11.HaCaT) cells were established by lentiviral infection and verified by immunofluorescence and western-blotting. Cell cycle, E6 gene mutations, APOBEC3s/E6 gene expression and subcellular localization were detected by FACS, 3D-PCR and sequencing, qRT-PCR and immunofluorescence respectively. RESULTS: The results suggested that A3A-HPV11.HaCaT cells were successfully established. Enhanced A3A induced S-phase arrest, G>A/C>T mutations and obvious reduction of E6 mRNA expression. A3A/A3B mRNA expression was up-regulated at 6h and 12h and obvious A3A staining existed throughout HPV11.HaCaT cells after rhIFN-ω treatment. RhIFN-ω could also inhibit mRNA expression of HPV11 E6 significantly. CONCLUSIONS: Enhanced A3A repressed HPV11 E6 expression through gene hypermutation, and rhIFN-ω might be an effective agent against HPV11 infection by up-regulation of A3A.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171116
[Lr] Last revision date:171116
[St] Status:In-Process
[do] DOI:10.1186/s12985-017-0878-2

  9 / 5051 MEDLINE  
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[PMID]: 28983946
[Au] Autor:Kawase M; Egawa K; Ishiji T; Nakagawa H
[Ad] Address:Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.
[Ti] Title:Human papillomavirus type 6/11 identified in an epidermoid cyst of the scrotum.
[So] Source:J Dermatol;, 2017 Oct 06.
[Is] ISSN:1346-8138
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:To date, epidermoid cysts associated with human papillomavirus (HPV) infection have been described mainly in palmoplantar locations, and have involved HPV types 60 and 57. In contrast, HPV-6/11 is a major cause of condyloma acuminatum. Here, we report the case of a healthy 31-year-old man who presented to our clinic with a 1-month history of a 1-cm, reddish-brown, cystic scrotal tumor with a punctum. The lesion was studied histologically, immunohistochemically and by DNA-DNAin situ hybridization. Histology revealed an epidermoid cyst with vacuolated keratinocytes with shrunken nuclei (koilocytes) in the cyst wall. Immunostaining was positive for HPV antigens and in situ hybridization revealed HPV-6/11 DNA in the koilocytes. This is the first report of an HPV-6/11-associated epidermoid cyst in the anogenital skin of an immunocompetent individual.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171006
[Lr] Last revision date:171006
[St] Status:Publisher
[do] DOI:10.1111/1346-8138.14089

  10 / 5051 MEDLINE  
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[PMID]: 28898279
[Au] Autor:Lopez-Diez E; Perez S; Carballo M; Iarrea A; de la Orden A; Castro M; Rodrguez M; Almuster S; Montero R; Perez M; Sanchez J; Ojea A
[Ad] Address:Department of Urology, University Hospital of Vigo, Vigo, Spain.
[Ti] Title:Lifestyle factors and oncogenic papillomavirus infection in a high-risk male population.
[So] Source:PLoS One;12(9):e0184492, 2017.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: High risk human papillomavirus (HR-HPV) infection in males is a health issue with implications for HPV-related lesions in their partners. The identification of risk factors for male infection may improve our understanding of HR-HPV transmission and prevention. The aim of this study was to evaluate the relationships between lifestyle, genital warts and HR-HPV infection. The study was focused on men with an increased risk of HR-HPV infection: male sexual partners of women diagnosed with high-grade squamous intraepithelial cervical lesions. METHODS: Men were enrolled and prospectively recruited within the first six months after diagnosis of cervical lesions in their female partners (n = 175, 2013-2016). Epidemiological and sexual behaviour data were obtained. The presence of genital warts was established by visual inspection. Detection and genotyping of HR-HPV infection in genital samples were performed with a Linear Array HPV Genotyping Test. All HR-HPV positive men were offered a follow-up exam at 12 months. SPSS version 19 was used for statistical analysis. RESULTS AND DISCUSSION: The prevalence of HR-HPV infection in men was 45.1% (79/175). Genital warts were observed in 10.3% (18/175) of the subjects. Detection of genital warts (OR 3.5, p = 0.015), smoking habits (OR 2.3, p = 0.006) and sexual debut before 16 years old (OR 2, p = 0.035) were associated with an increased risk for HR-HPV infection (univariate analysis). This association was also observed for genital warts and smoking status in a multivariate analysis. The same genotype was found after one year in 71.4% (20/28) of subjects. CONCLUSIONS: The presence of genital warts and smoking habits seem to be associated with a higher risk of HR-HPV infection in males. Earlier sexual debut may increase this risk. Extensive knowledge of the natural history of HR-HPV infection in males is an absolute requirement for the design and implementation of prevention strategies for the general population as well as for specific populations such as couples after treatment for high-grade cervical lesions.
[Mh] MeSH terms primary: Condylomata Acuminata/epidemiology
Sexual Behavior
Squamous Intraepithelial Lesions of the Cervix/epidemiology
[Mh] MeSH terms secundary: Adult
Aged
Condylomata Acuminata/virology
Female
Humans
Life Style
Male
Middle Aged
Papillomaviridae/genetics
Papillomaviridae/isolation & purification
Sexual Partners
Squamous Intraepithelial Lesions of the Cervix/virology
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171012
[Lr] Last revision date:171012
[Js] Journal subset:IM
[Da] Date of entry for processing:170913
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184492


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