Database : MEDLINE
Search on : Conjunctivitis [Words]
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[PMID]: 24642477
[Au] Autor:Ruiz-Felipe M; Ochoa-Zarzuela D; Gimeno-Peribáñez MJ; Madariaga-Ruiz B; Sáenz-Abad D
[Ad] Address:Medicina de Familia y Comunitaria, Centro de Salud Valdefierro, Sector III, Zaragoza, España....
[Ti] Title:Una conjuntivitis de etiología excepcional. [A conjunctivitis of exceptional origin].
[So] Source:Semergen;40(8):475-7, 2014 Nov-Dec.
[Is] ISSN:1578-8865
[Cp] Country of publication:Spain
[La] Language:spa
[Pt] Publication type:LETTER
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Data-Review

  2 / 13021 MEDLINE  
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[PMID]: 25244402
[Au] Autor:Heller W; Cruz M; Bhagat YR; De Leon JM; Felix C; Villanueva L; Hollander DA; Jensen H
[Ad] Address:1 Arizona Center for Clinical Trials , Phoenix, Arizona.
[Ti] Title:Gatifloxacin 0.5% administered twice daily for the treatment of acute bacterial conjunctivitis in patients one year of age or older.
[So] Source:J Ocul Pharmacol Ther;30(10):815-22, 2014 Dec.
[Is] ISSN:1557-7732
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:UNLABELLED: Abstract Purpose: To evaluate the efficacy and safety of gatifloxacin 0.5% ophthalmic solution administered twice daily for treatment of acute bacterial conjunctivitis. METHODS: Two identically designed, double-masked, multicenter studies in the United States and India enrolled patients 1 year or older with acute bacterial conjunctivitis. Patients were randomized to gatifloxacin 0.5% or vehicle treatment for 5 days. Clinical success in clearing conjunctival hyperemia and discharge at day 6 (primary endpoint) and day 4 and microbiological cure were determined. Isolates from positive conjunctival samples were tested for sensitivity and susceptibility. Safety measures included adverse events (AEs). Data from these 2 studies were pooled for these analyses. RESULTS: Of the 1437 randomized patients, 658 constituted the modified intent-to-treat population. Patient characteristics were similar between the pooled treatment groups. Clinical success occurred for 58.0% of gatifloxacin 0.5%-treated versus 45.5% vehicle-treated patients at day 6 (P=0.001) and for 23.7% versus 15.4% in the respective groups at day 4 (P=0.007). Microbiological cure was higher with gatifloxacin 0.5% than vehicle at days 4 and 6 (P<0.001 for both time points). The combined minimum inhibitory concentration required to inhibit 90% of isolates for gatifloxacin 0.5% was 2.0 µg/mL for gram-positive and gram-negative organisms. AEs were reported by 11.6% and 13.3% of patients in the gatifloxacin 0.5% and vehicle safety populations, respectively. One patient in each treatment group experienced a serious AE; neither was treatment related. CONCLUSIONS: The 0.5% concentration of gatifloxacin ophthalmic solution was safe and effective for treatment of acute bacterial conjunctivitis with twice-daily administration for 5 days.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1089/jop.2014.0040

  3 / 13021 MEDLINE  
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[PMID]: 11958742
[Au] Autor:Moreno Escobosa MC; Alonso Lebrero E; Sánchez Alonso A; Méndez Alcalde J; Rico Díaz MA; García Alvárez G; Bartolomé Zavala B
[Ad] Address:Allergy Department, Hospital Niño Jesús, Madrid. Spain.
[Ti] Title:Barnacle hypersensitivity.
[So] Source:Allergol Immunopathol (Madr);30(2):100-3, 2002 Mar-Apr.
[Is] ISSN:1578-1267
[Cp] Country of publication:Spain
[La] Language:eng
[Ab] Abstract:BACKGROUND: the aim of the present study is to investigate the responsible mechanism of different adverse reactions suffered by five patients, aged between six and thirty years-old, after consumption of barnacle. The symptoms were angioedema, dyspnea, generalized urticaria, conjunctivitis and one of them suffered from anaphylactic reaction. Four patients had personal atopic history. METHODS: the allergic study included prick by prick test with raw and boiled barnacle and prick-test with a standardized battery of shellfish and neumoallergens, specific-IgE determination to barnacle, crustacean and house-dust-mite and SDS-PAGE immunoblotting to barnacle. Even though an oral challenge was proposed to three of the patients, they were reluctant to do the test and eventually the challenges were not carried out. RESULTS: prick to prick tests were positive to barnacle for all of them. Specific-IgE was found in four patients. The western blotting results showed an IgE-binding band whose apparent molecular mass ranged between 58 and 68 kDa. CONCLUSIONS: barnacle could induce IgE-mediated adverse reaction. Our study has demonstrated the presence of an IgE-binding protein in barnacle extracts ranged between 58 and 68 kDa of molecular mass. It has not been previously described a crustacean allergen with the same molecular mass, so it could be a specific allergen from barnacle. We believe that further study will confirm this is the case.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:0204
[Js] Journal subset:IM
[St] Status:In-Process

  4 / 13021 MEDLINE  
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[PMID]: 11958737
[Au] Autor:Gürkan F; Davutog Lu M; Bilici M; Sincar N; Haspolat K
[Ad] Address:Assoc. Prof. Dr., Medical School, Diyarbakr, Turkey.
[Ti] Title:Pulmonary functions in atopic and nonatopic asthmatic children.
[So] Source:Allergol Immunopathol (Madr);30(2):70-3, 2002 Mar-Apr.
[Is] ISSN:1578-1267
[Cp] Country of publication:Spain
[La] Language:eng
[Ab] Abstract:BACKGROUND: we examined how lung function and certain clinical and laboratory characteristics in asthmatic children were changed according to skin test positivity to aeroallergens. METHODS: a skin prick test was conducted using standardized extracts of 10 different allergens in 56 children with bronchial asthma, aged 5-15 years, in Dicle University Hospital. Lung function was measured by Microplus spirometer. RESULTS: among the 56 subjects, asthma was classified as mild in 16, moderate in 42 and severe in 3. At least one skin prick test was positive (monosensitized) in 35 subjects (62 %) and positive reactivity to two or more aeroallergens (polysensitized) was found in 17 subjects (30 %). Positive skin test reactions to aeroallergens were associated with a decrease (as percentage of the predicted decrease) in FEV1, FVC and PEF values. Significant differences were also found between prick test-positive and -negative asthmatics in duration of breastfeeding (8.5 5 months vs 15 7 months, respectively, p < 0.007), age at which cow's milk had been started (5.7 1.6 vs 10.5 5.4, p = 0.004); total serum IgE concentration (350 221 IU/ml vs 234 164 IU/ml, p = 0.02), age at onset of asthma symptoms (2.5 1.9 years vs 4.1 2.2 years) and number of asthma attacks per year (7.0 3.1 vs 5.2 3.5, p = 0.012). When one-way ANOVA and a post-Hoc test were used, asthma attacks were more frequent and severe and allergic conjunctivitis symptoms were more frequent in the polysensitized group than in the nonsensitized and monosensitized groups (p = 0.03). CONCLUSIONS: children with positive skin prick test results, especially those with combined sensitivity to dust mite, cat and dog, were at increase risk of more severe asthma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:0204
[Js] Journal subset:IM
[St] Status:In-Process

  5 / 13021 MEDLINE  
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[PMID]: 25281489
[Au] Autor:Tananuvat N; Charoenkwan P; Ohazama A; Ketuda Cairns JR; Kaewgahya M; Kantaputra PN
[Ad] Address:Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand....
[Ti] Title:Root dentin anomaly and a PLG mutation.
[So] Source:Eur J Med Genet;57(11-12):630-5, 2014 Nov-Dec.
[Is] ISSN:1878-0849
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:We report a Thai girl affected with plasminogen deficiency, Type I. Ligneous conjunctivitis was first observed when she was one-month-old. The newly recognized findings include tapered incisor roots as a result of thin root dentin, generalized short tooth roots, and mandibular prognathism. Mutation analysis of PLG demonstrated homozygous c.1193G>A missense mutation. The parents were heterozygous for c.1193G>A mutation. The c.1193G>A mutation is novel and predicted to cause amino acid substitution p.Cys398Tyr. Thin root dentin in the patient who was affected with PLG mutation and immunolocalization of Plg during early root development in mice imply the role of plasminogen in root dentin formation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Data-Review

  6 / 13021 MEDLINE  
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[PMID]: 21982402
[Au] Autor:Sposato B; Scalese M
[Ad] Address:Unità di Pneumologia, Ospedale "Misericordia", Grosseto, Italy. Electronic address: bsposat@tin.it.
[Ti] Title:Prevalence and real clinical impact of Cupressus sempervirens and Juniperus communis sensitisations in Tuscan "Maremma", Italy.
[So] Source:Allergol Immunopathol (Madr);41(1):17-24, 2013 Jan-Feb.
[Is] ISSN:1578-1267
[Cp] Country of publication:Spain
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The aim was to evaluate the impact of Cupressus sempervirens (Cs) and Juniperus communis (Jc) sensitisations in "Maremma" in southern Tuscany. METHODS: 811 consecutive outpatients (357 F - 57.86%; age: 36.9 ± 16.6) with suspected allergic respiratory symptoms underwent skin prick tests (SPT) for common allergens and for Cs and Jc. RESULTS: SPT resulted negative in 295 (36.37%) subjects. A Cs/Jc sensitisation was found in 294 (36.25%): 289 (98.3%) were sensitised to Cs whereas 198 (67.34%) to Jc. There was a co-sensitisation between Cs and Jc in 193 (65.6%) subjects. Cs/Jc mono-sensitisation was found in 39 (13.6%) subjects. A higher number (p<0.0001) of Cs/Jc sensitised subjects reported winter (131-44.55%) and spring (124-42.2%) symptoms compared to Cs/Jc non-sensitised and non-allergic subjects. Most Cs/Jc sensitised subjects reported rhinitis and conjunctivitis (p<0.0001), whereas only few reported coughing and asthma (p<0.01). The most frequent co-sensitisation was with grass, olive and other trees in Cs/Jc subjects (p<0.001). Those who reported winter symptoms, likely influenced by Cupressaceae, rhinitis was the main symptom whereas asthma was less frequent. Cs/Jc sensitisation resulted to be a risk factor (OR: 1.73 [CI95% 1.18-2.55]) for rhinitis whereas the probability of being asthmatic was reduced (OR: 0.62 [CI95% 0.44-0.85]). CONCLUSION: The prevalence of Cs/Jc sensitisation is about 36% in "Maremma". However, only in 44% of the patients, Cs/Jc seem to cause typical winter symptoms. Rhinitis is the predominant symptom, whereas asthma is less frequent. Testing Cupressaceae sensitisation using Jc pollen extract, rather than Cs, may result to be less sensitive.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1410
[Js] Journal subset:IM
[St] Status:In-Process

  7 / 13021 MEDLINE  
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[PMID]: 25223647
[Au] Autor:Jelocnik M; Walker E; Pannekoek Y; Ellem J; Timms P; Polkinghorne A
[Ad] Address:Institute for Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia; Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Sippy Downs, Queensland , 4556 Australia....
[Ti] Title:Evaluation of the relationship between Chlamydia pecorum sequence types and disease using a species-specific multi-locus sequence typing scheme (MLST).
[So] Source:Vet Microbiol;174(1-2):214-22, 2014 Nov 7.
[Is] ISSN:1873-2542
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Chlamydia pecorum is globally associated with several ovine diseases including keratoconjunctivitis and polyarthritis. The exact relationship between the variety of C. pecorum strains reported and the diseases described in sheep remains unclear, challenging efforts to accurately diagnose and manage infected flocks. In the present study, we applied C. pecorum multi-locus sequence typing (MLST) to C. pecorum positive samples collected from sympatric flocks of Australian sheep presenting with conjunctivitis, conjunctivitis with polyarthritis, or polyarthritis only and with no clinical disease (NCD) in order to elucidate the exact relationships between the infecting strains and the range of diseases. Using Bayesian phylogenetic and cluster analyses on 62 C. pecorum positive ocular, vaginal and rectal swab samples from sheep presenting with a range of diseases and in a comparison to C. pecorum sequence types (STs) from other hosts, one ST (ST 23) was recognised as a globally distributed strain associated with ovine and bovine diseases such as polyarthritis and encephalomyelitis. A second ST (ST 69) presently only described in Australian animals, was detected in association with ovine as well as koala chlamydial infections. The majority of vaginal and rectal C. pecorum STs from animals with NCD and/or anatomical sites with no clinical signs of disease in diseased animals, clustered together in a separate group, by both analyses. Furthermore, 8/13 detected STs were novel. This study provides a platform for strain selection for further research into the pathogenic potential of C. pecorum in animals and highlights targets for potential strain-specific diagnostic test development.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Data-Review

  8 / 13021 MEDLINE  
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[PMID]: 22921805
[Au] Autor:Chen YJ; Yu HH; Yang YH; Lau YL; Lee WI; Chiang BL
[Ad] Address:Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan....
[Ti] Title:Recurrent abdominal pain as the presentation of tumor necrosis factor receptor-associated periodic syndrome (TRAPS) in an Asian girl: A case report and review of the literature.
[So] Source:J Microbiol Immunol Infect;47(6):550-4, 2014 Dec.
[Is] ISSN:1995-9133
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is characterized by periodic fever, cutaneous rash, conjunctivitis, lymphadenopathy, abdominal pain, myalgia, and arthralgia. It is a rare autosomal dominant disease and strongly associated with heterozygous mutations in the tumor necrosis factor (TNF) receptor super family 1A (TNFRSF1A) gene. It is believed to be more common in Western countries than in Asian countries. Here, we present the case of a 14-year-old girl with periodic fever and abdominal pain with elevation of inflammatory markers for 2 years. After extensive work-up of infectious etiology with negative results, the diagnosis of TRAPS was made although no gene mutations were identified in the TNFRSF1A gene, MVK gene, and NALP3/CIAS1 gene. She had partial clinical response to corticosteroids and immunomodulatory agents. However, the treatment response to TNF-α inhibitor etanercept was dramatic. She has remained symptom free under regular weekly to biweekly etanercept treatment for 2 years. We also reviewed the related literature and summarized the data of 10 Asian cases of TRAPS.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Data-Review

  9 / 13021 MEDLINE  
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[PMID]: 24962046
[Au] Autor:Liapakis IE; Paschalis EI; Zambacos GJ; Englander M; Mandrekas AD
[Ad] Address:OpsisClinical Plastic and Reconstructive Surgery, 48 Anogion St., 71304, Therissos, Heraklion-Crete, Greece. Electronic address: liapjo@yahoo.com....
[Ti] Title:Redraping of the fat and eye lift for the correction of the tear trough.
[So] Source:J Craniomaxillofac Surg;42(7):1497-502, 2014 Oct.
[Is] ISSN:1878-4119
[Cp] Country of publication:Scotland
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Tear trough deformity is very difficult to correct. It can appear at relatively young age and it deepens over the years due to laxity and loss of structural support. We describe a technique for the correction of tear trough deformity and mid-face laxity by means of redraping blepharoplasty and lateral "eye lift". MATERIALS AND METHODS: Upper lid markings were made and removal of the excess skin was employed. The herniated fat was removed from the nasal fat pad. Using a subciliary incision the dissection was completed at the level of the orbital rim and the fat was repositioned with 5-0 Monocryl (poliglecaprone 25, Ethicon) sutures at the inner canthus to correct the tear trough. Subsequently, a canthopexy performed to secure the lower eyelid. We then dissected the cheek over the periosteum of the zygomatic bone-arch and the flap was suspended through a tunnel at the periosteum of the upper-lateral orbit by 5-0 Monocryl (poliglecaprone 25, Ethicon) suture. RESULTS: Thirty-five procedures were performed between 2009 and 2013. Patients were followed for at least one year. Successful correction of the tear trough deformity with middle face elevation was achieved in all patients. Sclera show was noted in 7 patients but resolved over 3-6 months period with no surgical intervention. Diplopia was noted in 1 patient probably due to oedema and was released 4 weeks after the operation. The oedema was prolonged (more than 1.5 month) in 10 patients probably due to the lymphatic stasis. Conjunctivitis was also noted in 2 patients and was released by conservative treatment. CONCLUSION: Our technique of redraping blepharoplasty and mid-face lift describes a relatively new approach for the correction of the tear trough deformity and middle face laxity. It shows stable results for up to 4 years although longer follow-up is needed to confirm the stability of the correction.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Js] Journal subset:D; IM
[St] Status:In-Data-Review

  10 / 13021 MEDLINE  
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[PMID]: 24928063
[Au] Autor:Ogi K; Takabayashi T; Sakashita M; Susuki D; Yamada T; Manabe Y; Fujieda S
[Ad] Address:Division of Otorhinolaryngology, Shinseikai Toyama Hospital, Toyama 939-0243, Japan. Electronic address: ogikazu@shinseikai.or.jp....
[Ti] Title:Effect of Asian sand dust on Japanese cedar pollinosis.
[So] Source:Auris Nasus Larynx;41(6):518-22, 2014 Dec.
[Is] ISSN:1879-1476
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Asian sand dust (ASD), originating in the deserts of Mongolia and China, spreads over large areas and is associated with adverse effects on human health in East Asia, including asthma, heart disease, and some allergic diseases. However, the effect of ASD on patients with seasonal allergic rhinitis caused by Japanese cedar pollen (SAR-JCP), the most common form of allergic rhinitis, remains unclear. The aim of this study was to investigate the effect of ASD on SAR-JCP patients. METHODS: A total of 41 patients with SAR-JCP recorded nasal and ocular allergic symptom scores in a diary. We assessed the influence of ASD events on patients with SAR-JCP during the JCP season and before and after the JCP season. RESULTS: ASD events did not influence nasal and ocular allergy symptoms during the JCP season. Scores for sneezing and runny nose were significantly increased by ASD events in the pre-JCP season. Ocular symptom scores were significantly increased by ASD events in the post-JCP season. CONCLUSION: Our results suggest that ASD may exacerbate allergy symptoms even before mass scattering of JCP, which usually does not cause allergic symptoms in patients with SAR-JCP. ASD also induced conjunctivitis symptoms after the JCP season. However, we did not observe any adverse effects of ASD on allergic symptoms during the JCP season.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Data-Review


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