Database : MEDLINE
Search on : Conjunctivitis [Words]
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[PMID]: 27796360
[Au] Autor:Li J; Zhang L; Chen X; Chen D; Hua X; Bian F; Deng R; Lu F; Li Z; Pflugfelder SC; Li DQ
[Ad] Address:School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, China.
[Ti] Title:Pollen/TLR4 Innate Immunity Signaling Initiates IL-33/ST2/Th2 Pathways in Allergic Inflammation.
[So] Source:Sci Rep;6:36150, 2016 Oct 31.
[Is] ISSN:2045-2322
[Cp] Country of publication:England
[La] Language:ENG
[Ab] Abstract:Innate immunity has been extended to respond environmental pathogen other than microbial components. Here we explore a novel pollen/TLR4 innate immunity in allergic inflammation. In experimental allergic conjunctivitis induced by short ragweed (SRW) pollen, typical allergic signs, stimulated IL-33/ST2 signaling and overproduced Th2 cytokine were observed in ocular surface, cervical lymph nodes and isolated CD4(+) T cells of BALB/c mice. These clinical, cellular and molecular changes were significantly reduced/eliminated in TLR4 deficient (Tlr4-d) or MyD88 knockout (MyD88(-/-)) mice. Aqueous SRW extract (SRWe) directly stimulated IL-33 mRNA and protein expression by corneal epithelium and conjunctiva in wild type, but not in Tlr4-d or MyD88(-/-) mice with topical challenge. Furthermore, SRWe-stimulated IL-33 production was blocked by TLR4 antibody and NF-kB inhibitor in mouse and human corneal epithelial cells. These findings for the first time uncovered a novel mechanism by which SRW pollen initiates TLR4-dependent IL-33/ST2 signaling that triggers Th2-dominant allergic inflammation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:In-Data-Review
[do] DOI:10.1038/srep36150

  2 / 13984 MEDLINE  
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[PMID]: 27796213
[Au] Autor:Tabbara KF
[Ad] Address:a Department of Ophthalmology, College of Medicine , King Saud University and The Eye Center, The Eye Foundation for Research in Ophthalmology , Riyadh , Saudi Arabia.
[Ti] Title:Trachoma: A Review.
[So] Source:J Chemother;13(sup1):18-22, 2001 Apr.
[Is] ISSN:1973-9478
[Cp] Country of publication:England
[La] Language:ENG
[Ab] Abstract:Trachoma is a leading cause of preventable blindness worldwide. The disease is caused by an intracellular epithelial Gram-negative bacterium, Chlamydia trachomatis. The presence of children, overcrowding, and the lack of water in the household are factors that predispose to the transmission of the disease. The disease may remain asymptomatic but some patients many complain of redness, irritation, and ocular discharge. The principal initial clinical manifestation is a follicular conjunctivitis that may lead to conjunctival scarring, entropion, trichiasis, corneal thinning, and ulceration. Some patients develop corneal scars that lead to loss of vision. Despite the remarkable progress in our understanding of Chlamydial infections, the basic mechanisms involved in tissue damage and scarring remain to be elucidated. There are several effective therapeutic modalities for trachoma. Azithromycin oral single dose was found to be safe and effective in children with active trachoma. Conjunctival biopsy specimens obtained from adult patients receiving a single oral dose of azithromycin showed sustained high levels of azithromycin (above MIC of chlamydia) for up to 2 weeks after intake. These prolonged high levels of azithromycin in the conjunctival tissue following a single oral dose makes the drug suitable for the treatment of endemic trachoma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:In-Data-Review

  3 / 13984 MEDLINE  
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[PMID]: 27793114
[Au] Autor:Kyei S; Tettey B; Asiedu K; Awuah A
[Ad] Address:Department of Optometry, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape-Coast, Cape-Coast, PMB, Ghana. skyei@ucc.edu.gh.
[Ti] Title:Knowledge and awareness of ocular allergy among undergraduate students of public universities in Ghana.
[So] Source:BMC Ophthalmol;16(1):190, 2016 Oct 28.
[Is] ISSN:1471-2415
[Cp] Country of publication:England
[La] Language:ENG
[Ab] Abstract:BACKGROUND: Ocular allergy is a growing public health problem that greatly impacts the day-to-day life of sufferers and their families. Other aspects of their activities of daily living such as schooling, professional, and social life are affected hence an increased awareness and knowledge of ocular allergies, their detection and treatment is paramount. This study was to assess the level of knowledge and awareness of ocular allergy among undergraduate students of public universities in Ghana. METHODS: A descriptive cross sectional survey was conducted among 1000 students from three selected public universities in Ghana. Each respondent completed a questionnaire that had questions concerning awareness and knowledge of ocular allergy. RESULTS: Out of the 1000 students, 347 (34.7 %) were aware of ocular allergy. Of these 347 students, the level of knowledge of ocular allergy was generally low. Majority of the students had their source of information about ocular allergy from the media and the internet. There was statistical significant association among awareness of ocular allergy, sources of information and programme of study (p < 0.001). CONCLUSION: Level of awareness among university students is generally low. Students' programmes of study influenced their knowledge of ocular allergy. Public health measures are recommended to help educate students on the prevention and control of ocular allergy as well as the complications associated with this condition.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161030
[Lr] Last revision date:161030
[St] Status:In-Data-Review

  4 / 13984 MEDLINE  
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[PMID]: 27789492
[Au] Autor:MacBride-Stewart S
[Ad] Address:Prescribing and Pharmacy Support Unit. E-mail: Sean.MacBride-Stewart@ggc.scot.nhs.uk.
[Ti] Title:Antibiotic eye drops for conjunctivitis in infants at nursery.
[So] Source:Br J Gen Pract;66(652):558-559, 2016 Nov.
[Is] ISSN:1478-5242
[Cp] Country of publication:England
[La] Language:ENG
[Pt] Publication type:LETTER
[Em] Entry month:1610
[Cu] Class update date: 161030
[Lr] Last revision date:161030
[St] Status:In-Data-Review

  5 / 13984 MEDLINE  
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[PMID]: 27788889
[Au] Autor:Yazu H; Dogru M; Matsumoto Y; Fujishima H
[Ad] Address:Department of Ophthalmology, Hino Municipal Hospital, Tokyo, Japan; Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
[Ti] Title:Efficacy and safety of an eye wash solution in allergic conjunctivitis after conjunctival allergen challenge.
[So] Source:Ann Allergy Asthma Immunol;117(5):565-566, 2016 Nov.
[Is] ISSN:1534-4436
[Cp] Country of publication:United States
[La] Language:ENG
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161030
[Lr] Last revision date:161030
[St] Status:In-Data-Review

  6 / 13984 MEDLINE  
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[PMID]: 27788888
[Au] Autor:Gutiérrez Fernández D; Martínez RV; Lasa Luaces EM; Fernández AF; Andrés García JA; Varo FM
[Ad] Address:UGC Neumología-Alergia, Hospital Universitario Puerta del Mar, Cádiz, España. Electronic address: drgutierrezfernandez@gmail.com.
[Ti] Title:Allergic contact conjunctivitis and cross-reaction between phenylephrine and epinephrine due to phenylephrine eye drops.
[So] Source:Ann Allergy Asthma Immunol;117(5):564-565, 2016 Nov.
[Is] ISSN:1534-4436
[Cp] Country of publication:United States
[La] Language:ENG
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161030
[Lr] Last revision date:161030
[St] Status:In-Data-Review

  7 / 13984 MEDLINE  
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[PMID]: 27788397
[Au] Autor:Zhu L; Thunuguntla P; Liu Y; Hancock M; Jones C
[Ad] Address:Oklahoma State University Center for Veterinary Health Sciences Department of Veterinary Pathobiology Stillwater, OK 74078, USA; Yangzhou University, College of Veterinary Medicine and Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, 48 We
[Ti] Title:The ß-catenin signaling pathway stimulates bovine herpesvirus 1 productive infection.
[So] Source:Virology;500:91-95, 2016 Oct 24.
[Is] ISSN:1096-0341
[Cp] Country of publication:United States
[La] Language:ENG
[Ab] Abstract:Bovine herpes virus 1 (BoHV-1), an important bovine pathogen, causes conjunctivitis and disorders in the upper respiratory tract. Following acute infection, BoHV1 establishes life-long latency in sensory neurons. Recent studies demonstrated that viral gene products expressed in trigeminal ganglionic neurons during latency stabilize ß-catenin levels, an important signaling molecule that interacts with a family of DNA binding proteins (T-cell factors) and subsequently stimulates transcription. In this study, we provide new evidence demonstrating that BoHV-1 transiently increased ß-catenin protein levels in bovine kidney (CRIB) cells, but not in rabbit skin cells. ß-catenin dependent transcription was also stimulated by infection of CRIB cells. The ß-catenin small molecule inhibitor (iCRT14) significantly reduced the levels of BoHV-1 virus during productive infection of CRIB cells and rabbit skin cells. In summary, these studies suggested the ability of ß-catenin to stimulate cell survival and cell cycle regulatory factors enhances productive infection in non-neuronal cells.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161028
[Lr] Last revision date:161028
[St] Status:Publisher

  8 / 13984 MEDLINE  
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[PMID]: 27786545
[Au] Autor:Zicari AM; Cafarotti A; Occasi F; Lollobrigida V; Nebbioso M; Pecorella I; De Castro G; Spalice A; Loffredo L; Villa MP; Duse M
[Ad] Address:a Department of Pediatrics , "Sapienza" University of Rome , Rome , Italy.
[Ti] Title:Vitamin D levels in children affected by Vernal Keratoconjuctivitis.
[So] Source:Curr Med Res Opin;:1-18, 2016 Oct 27.
[Is] ISSN:1473-4877
[Cp] Country of publication:England
[La] Language:ENG
[Ab] Abstract:BACKGROUND: Vernal keratoconjunctivitis (VKC) is a chronic and often severe bilateral conjunctivitis. VKC etiology remains still unclear although endocrine, genetic, neurogenic and environmental factors have been implied. Vitamin D is a fat-soluble prohormone whose main function is the regulation of calcium and phosphate metabolism. The aim of this study was to evaluate serum vitamin D in children affected by VKC compared to the healthy children and investigate the relationship between its levels and disease severity. METHODS: 110 children; 47 affected by VKC aged between 5 and 12 years of life were enrolled at the Department of Pediatrics, Division of Allergy and Immunology, 'Sapienza' University of Rome. 63 healthy children with negative skin prick test (SPT), without allergic, ocular and systemic disease were used as controls. Serum samples were obtained in April from all the children included in the study. Vitamin D dosage was repeated in October in 20 patients after therapy and in 20 controls. A conjunctival scraping was performed in all children affected by VKC. RESULTS: Children affected by VKC had lower vitamin D levels compared to HC and we found an increase in vitamin D levels after therapy with cyclosporine eye drops 1% although this increase was lower than that of healthy controls. Moreover we found significant correlations between vitamin D level and the severity of the disease. CONCLUSIONS: The study shows that children affected by VKC have lower vitamin D levels when compared to healthy controls and highlights a significant correlation between its levels and disease severity.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161028
[Lr] Last revision date:161028
[St] Status:Publisher

  9 / 13984 MEDLINE  
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[PMID]: 27785298
[Au] Autor:Delmondes LM; Nunes MO; Azevedo AR; Oliveira MM; Coelho LE; Torres-Neto JD
[Ad] Address:Department of Medicine, Tiradentes University, Aracaju 49032-490, Brazil.
[Ti] Title:Clinical and Sociodemographic Aspects of Inflammatory Bowel Disease Patients.
[So] Source:Gastroenterology Res;8(3-4):207-215, 2015 Aug.
[Is] ISSN:1918-2805
[Cp] Country of publication:Canada
[La] Language:ENG
[Ab] Abstract:BACKGROUND: In Brazil, there are few epidemiological studies available about the demographic and clinical aspects of inflammatory bowel disease (IBD). The aim of this study was to identify epidemiological and clinical characteristics of patients with IBD treated at the University Hospital (HU) of the Sergipe Federal University (UFS). METHODS: A cross-sectional descriptive study was conducted in HU/UFS from October 2011 to January 2014. The sample consisted of 87 patients with IBD, who registered in the coloproctology clinic. We applied a questionnaire with sociodemographic and clinical variables. RESULTS: Of the 87 patients, 40 (46%) had Crohn's disease (CD) and 47 (54%) had ulcerative colitis (UC). Women had a higher prevalence of IBD. Data obtained were significant (P < 0.05) in the variables: age, origin and level of education. CD patients were younger (< 25 years old), had higher prevalence of smoking habits and were associated with urban origin, conjunctivitis, palpable mass, appendectomy and intestinal complications. UC was more prevalent in older individuals (> 25 years old), with rural origin, bloody diarrhea and rectal bleeding. Location and initial behavior of CD were ileum-colic (L3), inflammatory behavior and penetrating form of the disease. There is higher prevalence of proctitis and mild and severe forms of the UC among women. Osteoarticular and systemic manifestations predominated in both diseases. CONCLUSIONS: IBD affected more women than men. The age, origin and level of education can interfere with early diagnosis. Demographic and clinical aspects were similar to the literature. Data differ in the time interval between the onset of symptoms and diagnosis, smoking habit, appendectomy and severity of UC for age and gender.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161028
[Lr] Last revision date:161028
[St] Status:In-Data-Review

  10 / 13984 MEDLINE  
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[PMID]: 27783678
[Au] Autor:Ramadhani AM; Derrick T; Macleod D; Holland MJ; Burton MJ
[Ad] Address:Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, United Kingdom.
[Ti] Title:The Relationship between Active Trachoma and Ocular Chlamydia trachomatis Infection before and after Mass Antibiotic Treatment.
[So] Source:PLoS Negl Trop Dis;10(10):e0005080, 2016 Oct.
[Is] ISSN:1935-2735
[Cp] Country of publication:United States
[La] Language:ENG
[Ab] Abstract:BACKGROUND: Trachoma is a blinding disease, initiated in early childhood by repeated conjunctival infection with the obligate intracellular bacterium Chlamydia trachomatis. The population prevalence of the clinical signs of active trachoma; ''follicular conjunctivitis" (TF) and/or ''intense papillary inflammation" (TI), guide programmatic decisions regarding the initiation and cessation of mass drug administration (MDA). However, the persistence of TF following resolution of infection at both the individual and population level raises concerns over the suitability of this clinical sign as a marker for C. trachomatis infection. METHODOLOGY/PRINCIPLE FINDINGS: We systematically reviewed the literature for population-based studies and those including randomly selected individuals, which reported the prevalence of the clinical signs of active trachoma and ocular C. trachomatis infection by nucleic acid amplification test. We performed a meta-analysis to assess the relationship between active trachoma and C. trachomatis infection before and after MDA. TF and C. trachomatis infection were strongly correlated prior to MDA (r = 0.92, 95%CI 0.83 to 0.96, p<0.0001); the relationship was similar when the analysis was limited to children. A moderate correlation was found between TI and prevalence of infection. Following MDA, the relationship between TF and infection prevalence was weaker (r = 0.60, 95%CI 0.25 to 0.81, p = 0.003) and there was no correlation between TI and C. trachomatis infection. CONCLUSIONS/SIGNIFICANCE: Prior to MDA, TF is a good indicator of the community prevalence of C. trachomatis infection. Following MDA, the prevalence of TF tends to overestimate the underlying infection prevalence. In order to prevent unnecessary additional rounds of MDA and to accurately ascertain when elimination goals have been reached, a cost-effective test for C. trachomatis that can be administered in low-resource settings remains desirable.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161027
[Lr] Last revision date:161027
[St] Status:In-Data-Review
[do] DOI:10.1371/journal.pntd.0005080


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