Database : MEDLINE
Search on : Conjunctivitis [Words]
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[PMID]: 27279226
[Au] Autor:Cugola FR; Fernandes IR; Russo FB; Freitas BC; Dias JL; Guimarães KP; Benazzato C; Almeida N; Pignatari GC; Romero S; Polonio CM; Cunha I; Freitas CL; Brandão WN; Rossato C; Andrade DG; Faria Dde P; Garcez AT; Buchpigel CA; Braconi CT; Mendes E; Sall AA; Zanotto PM; Peron JP; Muotri AR; Beltrão-Braga PC
[Ad] Address:University of São Paulo, Department of Surgery, Stem Cell Laboratory, São Paulo, São Paulo 05508-270, Brazil....
[Ti] Title:The Brazilian Zika virus strain causes birth defects in experimental models.
[So] Source:Nature;534(7606):267-71, 2016 Jun 9.
[Is] ISSN:1476-4687
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Zika virus (ZIKV) is an arbovirus belonging to the genus Flavivirus (family Flaviviridae) and was first described in 1947 in Uganda following blood analyses of sentinel Rhesus monkeys. Until the twentieth century, the African and Asian lineages of the virus did not cause meaningful infections in humans. However, in 2007, vectored by Aedes aegypti mosquitoes, ZIKV caused the first noteworthy epidemic on the Yap Island in Micronesia. Patients experienced fever, skin rash, arthralgia and conjunctivitis. From 2013 to 2015, the Asian lineage of the virus caused further massive outbreaks in New Caledonia and French Polynesia. In 2013, ZIKV reached Brazil, later spreading to other countries in South and Central America. In Brazil, the virus has been linked to congenital malformations, including microcephaly and other severe neurological diseases, such as Guillain-Barré syndrome. Despite clinical evidence, direct experimental proof showing that the Brazilian ZIKV (ZIKV(BR)) strain causes birth defects remains absent. Here we demonstrate that ZIKV(BR) infects fetuses, causing intrauterine growth restriction, including signs of microcephaly, in mice. Moreover, the virus infects human cortical progenitor cells, leading to an increase in cell death. We also report that the infection of human brain organoids results in a reduction of proliferative zones and disrupted cortical layers. These results indicate that ZIKV(BR) crosses the placenta and causes microcephaly by targeting cortical progenitor cells, inducing cell death by apoptosis and autophagy, and impairing neurodevelopment. Our data reinforce the growing body of evidence linking the ZIKV(BR) outbreak to the alarming number of cases of congenital brain malformations. Our model can be used to determine the efficiency of therapeutic approaches to counteracting the harmful impact of ZIKV(BR) in human neurodevelopment.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1606
[Cu] Class update date: 160610
[Lr] Last revision date:160610
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1038/nature18296

  2 / 13715 MEDLINE  
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[PMID]: 27275431
[Au] Autor:Long Q; Zuo YG; Yang X; Gao TT; Liu J; Li Y
[Ad] Address:Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China....
[Ti] Title:Clinical features and in vivo confocal microscopy assessment in 12 patients with ocular cicatricial pemphigoid.
[So] Source:Int J Ophthalmol;9(5):730-7, 2016.
[Is] ISSN:2222-3959
[Cp] Country of publication:China
[La] Language:eng
[Ab] Abstract:AIM: To describe the clinical features and microstructural characteristics assessed by in vivo confocal microscopy (IVCM) in patients with ocular cicatricial pemphigoid (OCP). METHODS: A descriptive, uncontrolled case series study. Patients diagnosed with OCP were examined by clinical history, slit-lamp biomicroscopy features and IVCM images. The results of direct immunofluorescence (DIF) biopsies and indirect immunofluorescence (IIF) were also recorded. Local and systemic immunosuppressive therapy were administered and adjusted according to response. RESULTS: A total of 12 consecutive OCP patients (7 male, 5 female; mean age 60.42±10.39y) were recruited. All patients exhibited bilateral progressive conjunctival scarring and recurrent chronic conjunctivitis was the most frequent clinical pattern. The mean duration of symptoms prior to diagnosis of OCP was 2.95±2.85y (range: 5mo to 10y). The Foster classification varied from stage I to IV and 20 eyes (83%) were within or greater than Foster stage III on presentation. Two of the 12 patients (17%) demonstrated positive DIF; 3 of the 12 (25%) patients reported positive IIF. The mean duration of the follow-up period was 20.17±11.88mo (range: 6 to 48mo). IVCM showed variable degrees of abnormality in the conjuctiva-cornea and conjuctival scarring was detected in all the involved eyes. Corneal stromal cell activation and dendritic cell infiltration presented as ocular surface inflammation, ocular surface keratinization along with the destroyed Vogt palisades was noted in eyes with potential limbal stem cell deficiency. After treatment, remission of ocular surface inflammation was achieved in all the patients, 18 eyes (75%) remained stable, 6 eyes (25%) had recurrent conjunctivitis and cicatrization in 2 eyes (8%) was progressing. CONCLUSION: As an autoimmune disease, OCP manifests as variable degrees of clinical and laboratory abnormalities with both local and systemic immunosuppressive treatment playing important roles in disease therapy. IVCM can be as a valuable non-invasive technique to assess ocular surface changes in a cellular level with a potential value for providing diagnostic evidence and monitoring therapeutic effects during follow-up.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Cu] Class update date: 160610
[Lr] Last revision date:160610
[Da] Date of entry for processing:160609
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.18240/ijo.2016.05.17

  3 / 13715 MEDLINE  
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[PMID]: 27224053
[Au] Autor:Hsieh VC; Liu CC; Hsiao YC; Wu TN
[Ad] Address:Department of Health Services Administration, College of Public Health, China Medical University, Taichung, Taiwan....
[Ti] Title:Risk of Allergic Rhinitis, Allergic Conjunctivitis, and Eczema in Children Born to Mothers with Gum Inflammation during Pregnancy.
[So] Source:PLoS One;11(5):e0156185, 2016.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: Despite links between maternal and child health status, evidence on the association between gum infection in pregnant mothers and childhood allergies is scarce. We aim to evaluate the risk of developing allergy in children born to periodontal mothers in a nationwide study. METHODS: We conducted a 9-year population-based, retrospective cohort study using Taiwan's National Health Insurance database. A study cohort of 42,217 newborns born to mothers with periodontal disease during pregnancy was identified in 2001 and matched with 42,334 babies born to mothers without any infection (control) by mother's age at delivery and baby sex. With a follow-up period from 2001 to 2010, we observed the incidence of allergic rhinitis (AR), allergic conjunctivitis (AC), and eczema in these children. Cox proportional hazards regression models were performed with premature deaths as competing risk for the estimation of allergic disease risks. RESULTS: Nine-year cumulative incidences were the highest among children born to periodontal mothers; they reached 46.8%, 24.2%, and 40.4% (vs. 39.5%, 18.3% and 34.8% in control) for AR, AC, and eczema, respectively. Our results showed moderately increased risks for the allergies in children born to periodontal mothers relative to their matched non-inflammatory control (adjusted HRs: 1.17, 95% CI: 1.15-1.20; 1.27, 1.24-1.31; 1.14, 1.12-1.17, respectively). Because the impact of food consumption and living environment cannot be considered using insurance data, we attempted to control it by adjusting for parental income and mother's residential area. CONCLUSIONS: Overall cumulative incidence and risks of children born to periodontal mothers for AR, AC, and eczema are significantly higher than those born to non-inflammatory mothers. Gum infection in women during pregnancy is an independent risk factor for allergic diseases in children, thus its intergenerational consequences should be considered in gestational care.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1605
[Cu] Class update date: 160610
[Lr] Last revision date:160610
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1371/journal.pone.0156185

  4 / 13715 MEDLINE  
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[PMID]: 27281835
[Au] Autor:Mounsey AL; Gray RE
[Ad] Address:University of North Carolina School of Medicine, Chapel Hill, NC, USA.
[Ti] Title:Topical Antihistamines and Mast Cell Stabilizers for Treating Allergic Conjunctivitis.
[So] Source:Am Fam Physician;93(11):915-6, 2016 Jun 1.
[Is] ISSN:1532-0650
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review

  5 / 13715 MEDLINE  
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[PMID]: 26740466
[Au] Autor:Baig MS; Ahad A; Aslam M; Imam SS; Aqil M; Ali A
[Ad] Address:Faculty of Pharmacy, Jamia Hamdard (Hamdard University), M.B. Road, New Delhi 110062, India....
[Ti] Title:Application of Box-Behnken design for preparation of levofloxacin-loaded stearic acid solid lipid nanoparticles for ocular delivery: Optimization, in vitro release, ocular tolerance, and antibacterial activity.
[So] Source:Int J Biol Macromol;85:258-70, 2016 Apr.
[Is] ISSN:1879-0003
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:The aim of the present study was to develop and optimize levofloxacin loaded solid lipid nanoparticles for the treatment of conjunctivitis. Box-Behnken experimental design was applied for optimization of solid lipid nanoparticles. The independent variables were stearic acid as lipid (X1), Tween 80 as surfactant (X2) and sodium deoxycholate as co-surfactant (X3) while particle size (Y1) and entrapment efficiency (Y2) were the dependent variables. Further in vitro release and antibacterial activity in vitro were also performed. The optimized formulation of levofloxacin provides particle size of 237.82 nm and showed 78.71% entrapment efficiency and achieved flux 0.2,493 µg/cm(2)/h across excised goat cornea. In vitro release study showed prolonged drug release from the optimized formulation following Korsmeyer-Peppas model. Antimicrobial study revealed that the developed formulation possesses antibacterial activity against Staphylococcus aureus, and Escherichia coli equivalent to marketed eye drops. HET-CAM test demonstrated that optimized formulation was found to be non-irritant and safe for topical ophthalmic use. Our results concluded that solid lipid nanoparticles are an efficient carrier for ocular delivery of levofloxacin and other drugs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1602
[Js] Journal subset:IM
[St] Status:In-Process

  6 / 13715 MEDLINE  
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[PMID]: 27142484
[Au] Autor:Ko R; Hayashi M; Hayashi H; Hayashi K; Kato H; Kurata Y; Fuchino Y; Nakamichi T; Migita H; Yano H; Sakata T; Uchio E
[Ad] Address:a Department of Ophthalmology , Fukuoka University , Fukuoka , Japan....
[Ti] Title:Correlation between acute conjunctivitis and Asian dust on ocular surfaces.
[So] Source:J Toxicol Environ Health A;79(8):367-75, 2016.
[Is] ISSN:1528-7394
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The aim of this study was to determine the presence of Asian dust particles (ADP) in patients suffering from conjunctivitis and its correlation with clinical scores for conjunctivitis. Forty-five patients from the Fukuoka area who were newly diagnosed acute conjunctivitis were selected. The degrees of inflammatory reaction, itchy sensation, hyperemia, eye discharge, and foreign body sensation were clinically recorded and scored. Eyes were washed with physiological solution. Solid particles collected from the washing solution were observed using a scanning electron microscope. Of the 45 samples, 44 were positive for the elements silicon (Si) and aluminum (Al), which are components of ambient Asian dust. Higher conjunctivitis scores were found in the subgroup in which the Asian dust/whole particle ratio was greater than average. This is the first apparent report on the correlation between amount of ADP exposure at the ocular surface and severity of ocular symptoms.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1080/15287394.2016.1162248

  7 / 13715 MEDLINE  
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[PMID]: 26584064
[Au] Autor:King R; Langrock R
[Ad] Address:School of Mathematics, University of Edinburgh, James Clerk Maxwell Building, The King's Buildings, Peter Guthrie Tait Road, Edinburgh EH9 3FD, UK.
[Ti] Title:Semi-Markov Arnason-Schwarz models.
[So] Source:Biometrics;72(2):619-28, 2016 Jun.
[Is] ISSN:1541-0420
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We consider multi-state capture-recapture-recovery data where observed individuals are recorded in a set of possible discrete states. Traditionally, the Arnason-Schwarz model has been fitted to such data where the state process is modeled as a first-order Markov chain, though second-order models have also been proposed and fitted to data. However, low-order Markov models may not accurately represent the underlying biology. For example, specifying a (time-independent) first-order Markov process involves the assumption that the dwell time in each state (i.e., the duration of a stay in a given state) has a geometric distribution, and hence that the modal dwell time is one. Specifying time-dependent or higher-order processes provides additional flexibility, but at the expense of a potentially significant number of additional model parameters. We extend the Arnason-Schwarz model by specifying a semi-Markov model for the state process, where the dwell-time distribution is specified more generally, using, for example, a shifted Poisson or negative binomial distribution. A state expansion technique is applied in order to represent the resulting semi-Markov Arnason-Schwarz model in terms of a simpler and computationally tractable hidden Markov model. Semi-Markov Arnason-Schwarz models come with only a very modest increase in the number of parameters, yet permit a significantly more flexible state process. Model selection can be performed using standard procedures, and in particular via the use of information criteria. The semi-Markov approach allows for important biological inference to be drawn on the underlying state process, for example, on the times spent in the different states. The feasibility of the approach is demonstrated in a simulation study, before being applied to real data corresponding to house finches where the states correspond to the presence or absence of conjunctivitis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/biom.12446

  8 / 13715 MEDLINE  
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[PMID]: 26530900
[Au] Autor:Teng JL; Tang Y; Wong SS; Ngan AH; Huang Y; Tsang CC; Choi GK; Lau SK; Woo PC
[Ad] Address:1​Department of Microbiology, The University of Hong Kong, Hong Kong 3​Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong 2​State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong 4​Carol Yu Centre for Infection, The Unive...
[Ti] Title:Tsukamurella hongkongensis sp. nov. and Tsukamurella sinensis sp. nov., isolated from patients with keratitis, catheter-related bacteraemia and conjunctivitis.
[So] Source:Int J Syst Evol Microbiol;66(1):391-7, 2016 Jan.
[Is] ISSN:1466-5034
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Three bacterial strains, HKU51T, HKU52T and HKU53, were isolated from a conjunctival swab, corneal scraping and blood culture of three patients in Hong Kong with conjunctivitis, keratitis and catheter-related bacteraemia, respectively. Cells were Gram-stain-positive, aerobic, catalase-positive, non-sporulating and non-motile bacilli. The three strains had unique biochemical profiles that were distinguishable from those of closely related species of the genus Tsukamurella. Fatty acids, mycolic acids, cell-wall sugars and peptidoglycan analyses showed that they were typical of members of Tsukamurella. 16S rRNA gene sequence analysis revealed 100 % sequence identity between HKU52T and HKU53, and the two strains shared 99.5 % sequence identity with Tsukamurella sunchonensis JCM 15929T and Tsukamurella pseudospumae JCM 13375T; HKU51T shared 99.6 % sequence identity with Tsukamurella pulmonis CCUG 35732T. The DNA G+C contents of strains HKU51T, HKU52T and HKU53 were 70.9 ± 2.2, 71.3 ± 2.1 and 71.2 ± 2.3 mol% (mean ± sd; n = 3), respectively. DNA-DNA hybridization confirmed that the novel strains were distinct from other known species of the genus Tsukamurella ( ≤ 50.1 ± 3.7 % DNA-DNA relatedness); two of the isolates, HKU52T and HKU53, represented the same species ( ≥ 94.6 ± 5.6 % DNA-DNA relatedness), while the third isolate, HKU51T, represented another species. The novel species Tsukamurella hongkongensis sp. nov. is proposed to accommodate strains HKU52T and HKU53, with HKU52T ( = JCM 30715T = DSM 100208T) as the type strain; whilst another novel species, Tsukamurella sinensis sp. nov., is proposed to accommodate the third isolate, HKU51T ( = JCM 30714T = DSM 100207T), which is designated the type strain.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1602
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1099/ijsem.0.000733

  9 / 13715 MEDLINE  
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[PMID]: 26578052
[Au] Autor:Racil H; Loukil M; Ferah Y; Cheikh Rouhou S; Chaouch N; Yaalaoui S; Chabbou A
[Ti] Title:The Pollen-Food Olive-Olive Syndrome.
[So] Source:Tunis Med;93(5):326-7, 2015 May.
[Is] ISSN:0041-4131
[Cp] Country of publication:Tunisia
[La] Language:eng
[Ab] Abstract:BACKGROUND: The pollen-foods syndrome is rare and of difficult diagnosis. The aim is to report a rare case, it's the four case reported in the literature. CASE REPORT: A 48-year-old woman presenting with palatal itching and generalized urticaria following ingestion of olive fruit, 5 years after being diagnosed with olive pollinosis. She did not have a history of other food allergy or urticaria. The prick-test was positive in olive pollen.The olive pollen specific IgE was positive. The oral provocation test was positive for olives and negative for olive oil. The diagnosis of "pollen-food olive-olive syndrome" was accepted. Interestingly, in this rare case the patient developed olive fruit allergy in the presence of olive pollinosis, but did not experience allergic symptoms to fruits other than olive. CONCLUSION: In spite its rarity this syndrome should be evoke particularly in our country.
[Mh] MeSH terms primary: Food Hypersensitivity/etiology
Olea/adverse effects
Rhinitis, Allergic, Seasonal/complications
[Mh] MeSH terms secundary: Asthma/etiology
Conjunctivitis/etiology
Female
Humans
Middle Aged
Pruritus/etiology
Rhinitis/etiology
Syndrome
Urticaria/etiology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[Da] Date of entry for processing:151120
[St] Status:MEDLINE

  10 / 13715 MEDLINE  
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[PMID]: 26351635
[Au] Autor:Pfaar O; Richter HG; Klimek L; Sieber J; Hadler M; Karagiannis E
[Ad] Address:Center for Rhinology and Allergology, 65183 Wiesbaden, Germany ; Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany....
[Ti] Title:Sublingual Immunotherapy with a Five-Grass Pollen Tablet in Adult Patients with Allergic Rhinitis: An Open, Prospective, Noninterventional, Multicenter Study.
[So] Source:Biomed Res Int;2015:584291, 2015.
[Is] ISSN:2314-6141
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Although the safety and efficacy of sublingual immunotherapy (SLIT) with a five-grass pollen tablet have been demonstrated in randomized clinical trials (RCTs), these outcomes must always be evaluated in real-life medical practice. METHODS: In a prospective, open-label, noninterventional, "real-life" study in Germany, we evaluated the safety, tolerability, and effectiveness of SLIT with a five-grass pollen tablet in adults with grass-pollen-induced allergic rhinoconjunctivitis. RESULTS: 808 adults were enrolled between September 2008 and December 2009. 35.3% of the participants experienced at least one adverse drug reaction (ADR), the most common of which were mild-to-moderate gastrointestinal and respiratory disorders. Serious ADRs considered causally related to SLIT treatment occurred in four patients. Overall, the five-grass pollen tablet was considered to have good or very good tolerability by most investigators and patients. Treatment was associated with the relief of nasal, ocular, and bronchial symptoms and decreased symptomatic medication use. However, interpretation of clinical improvements was limited by lower atmospheric grass pollen levels during the study season (relative to the preceding season). CONCLUSIONS: In a large population of patients treated in real-life medical practice, SLIT with a five-grass pollen tablet was safe and well tolerated. The patient-reported symptom relief suggests that SLIT was associated with clinical benefits.
[Mh] MeSH terms primary: Allergens/immunology
Poaceae/immunology
Pollen/immunology
Rhinitis, Allergic, Seasonal/immunology
Tablets/administration & dosage
[Mh] MeSH terms secundary: Administration, Sublingual
Adolescent
Adult
Aged
Aged, 80 and over
Conjunctivitis, Allergic/immunology
Desensitization, Immunologic/methods
Female
Germany
Humans
Male
Middle Aged
Prospective Studies
Seasons
Sublingual Immunotherapy/methods
Young Adult
[Pt] Publication type:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Name of substance:0 (Allergens); 0 (Tablets)
[Em] Entry month:1606
[Cu] Class update date: 150912
[Lr] Last revision date:150912
[Js] Journal subset:IM
[Da] Date of entry for processing:150909
[St] Status:MEDLINE
[do] DOI:10.1155/2015/584291


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