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[PMID]: 25784255
[Au] Autor:Corchia A; Limelette A; Hubault B; Robbins A; Quinquenel A; Bani-Sadr F; N'Guyen Y
[Ad] Address:Service de Médecine Interne, Maladies Infectieuses et Immunologie Clinique, Hôpital Robert Debré, Avenue Général Koenig, 51100, Reims, France, anthonycorchia@gmail.com.
[Ti] Title:Rapidly evolving conjunctivitis due to Pasteurella multocida, occurring after direct inoculation with animal droplets in an immuno-compromised host.
[So] Source:BMC Ophthalmol;15(1):2, 2015 Dec.
[Is] ISSN:1471-2415
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: The rare descriptions, in the literature, of ocular infections due to Pasteurella multocida include: endophtalmitis, keratitis and corneal ulcers, Parinaud's oculoglandular syndrome, and conjunctivitis. Here, we report a rare case of rapidly evolving conjunctivitis due to Pasteurella multocida, occurring after direct inoculation with animal droplets in an immuno-compromised host. CASE PRESENTATION: A 69-year-old, Caucasian male was referred to our department with purulent conjunctivitis, occurring five days after chemotherapy for an angioimmunoblastic-T-cell-lymphoma, and thirty-three hours after being struck in his right eye by his sneezing Dachshund dog. Physical examination revealed purulent conjunctivitis of the right eye associated with inflammatory edema of both lids. Direct bacteriological examination of conjunctival secretions showed gram-negative bacilli and regular, grey non-hemolytic colonies appearing the next day on blood agar. The oxidase test was positive for these colonies. An antibiotherapy associating intravenous amoxicillin and amoxicillin/clavulanate was administered. The outcome was favorable in the next three days allowing discharge of the patient with amoxicillin (2 g tid per os). CONCLUSION: This case report may be of interest for infectious diseases, ophthalmology or oncology specialists, especially nowadays with chemotherapy being administered in day care centres, where unusual home pathogens can be encountered in health related infections. In this case, previous animal contact and conjunctival samples showing Enterobacteriaceae like colonies with positive oxidase test were two important clues which could help clinicians to make the diagnosis of Pasteurella conjunctivitis in every day practice.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Cu] Class update date: 150321
[Lr] Last revision date:150321
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1186/s12886-015-0002-6

  2 / 13141 MEDLINE  
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[PMID]: 25680346
[Au] Autor:Ozturk AB; Ozyigit LP; Olmez MO
[Ad] Address:Allergy and Immunology Department, Koç University Hospital, Istanbul, Turkey, aysebilgeozturk@yahoo.com.
[Ti] Title:Clinical and allergic sensitization characteristics of allergic rhinitis among the elderly population in Istanbul, Turkey.
[So] Source:Eur Arch Otorhinolaryngol;272(4):1033-5, 2015 Apr.
[Is] ISSN:1434-4726
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Prevalence of allergic rhinitis (AR) in elderly population in Turkey is not known. Studies on the prevalence and features of allergy in older adults are needed to identify safe and effective diagnostic/therapeutic methods for elderly AR patients. We aimed to identify the clinical and allergic characteristics of sensitization to aeroallergens among individuals aged ≥60 years with allergic rhinitis admitted to an allergy outpatient clinic in Istanbul. Of 109 patients, 33.9 % were atopic. Sixty-five percent of subjects were sensitized to Dermatophagoides pteronyssinus, 17 % to a grass-pollen mixture, 8 % to Aspergillus fumigatus, and 8 % to Blattella germanica. There was no difference between mono- and polysensitized patients in terms of the duration of rhinitis and symptom severity. No significant difference was observed between the two groups according to age, sex, smoking status, AR onset (<40 or ≥40 years), or duration/severity of disease. There was no significant difference between the two groups in the prevalence of asthma and conjunctivitis, (p = 0.256). Atopic dermatitis/eczema was more prevalent in those with AR (p = 0.046). Clinical characteristics of AR in the elderly could be different from those in non-allergic patients, and the prevalence of allergy may be higher than expected.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00405-015-3552-6

  3 / 13141 MEDLINE  
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[PMID]: 24678747
[Au] Autor:Mimura T; Yamagami S; Noma H; Kamei Y; Goto M; Kondo A; Matsubara M
[Ad] Address:Department of Ophthalmology, University of Tokyo Graduate School of Medicine , Bunkyo-ku , Japan .
[Ti] Title:Specific IgE for wheat in tear fluid of patients with allergic conjunctivitis.
[So] Source:Cutan Ocul Toxicol;34(1):25-34, 2015 Mar.
[Is] ISSN:1556-9535
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:CONTEXT: Allergy to hydrolyzed wheat protein in facial soap has become a major social issue in Japan. It has been reported that the most frequent early symptoms of allergy to hydrolyzed wheat protein in soap are allergic conjunctivitis and rhinitis, while wheat-dependent exercise-induced anaphylaxis can be induced by long-term use. OBJECTIVE: We evaluated the relation between tear fluid levels of specific IgE for wheat and the features of allergic conjunctivitis. METHODS: A prospective, non-randomized, cross-sectional study was conducted in 103 patients with moderate to severe allergic conjunctivitis (allergic group) and 20 age- and sex-matched healthy control subjects (control group). Specific IgE for wheat was measured in tear fluid with an immunochromatography assay, and a skin prick test (SPT) was also performed. Symptoms (sneezing, rhinorrhea, nasal obstruction, ocular itching, and lacrimation) were assessed in each subject along with the activities of daily living (ADL) score and the total ocular symptom score for allergic conjunctivitis. A severity score (0, 1, 2, or 3) was assigned for various changes of the palpebral and bulbar conjunctiva, as well as for limbal and corneal lesions associated with allergic conjunctivitis. RESULTS: The IgE positive rate and specific IgE score were both higher in the allergic group than in the control group (71.8% versus 40.0% and 1.9 ± 0.7 versus 1.4 ± 0.5). A positive SPT for wheat was also more frequent in the allergic group than in the control group (6.8% versus 0.0%). Within the allergic group, patients with a positive SPT had higher specific IgE scores than patients with a negative SPT (3.3 ± 0.5 versus 1.8 ± 0.6, p < 0.001). In the allergic group, the wheat IgE level in tear fluid was correlated with the severity of allergic conjunctivitis symptoms, including ocular itching (r = 0.665), tearing (r = 0.672), and the total ocular symptom score (r = 0.204). Wheat IgE in tear fluid was also correlated with the severity of rhinitis symptoms, including sneezing (r = 0.610), nose blowing (r = 0.640), and nasal obstruction (r = 0.677). Furthermore, the tear fluid wheat IgE score was correlated with five objective features of allergic conjunctivitis (p < 0.05). CONCLUSIONS: These results suggest that wheat allergy may be involved in the development of allergic conjunctivitis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.3109/15569527.2014.890938

  4 / 13141 MEDLINE  
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[PMID]: 24678746
[Au] Autor:Özen Tunay Z; Ozdemir O; Petricli IS
[Ad] Address:Department of Ophthalmology, Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey and.
[Ti] Title:Povidone iodine in the treatment of adenoviral conjunctivitis in infants.
[So] Source:Cutan Ocul Toxicol;34(1):12-5, 2015 Mar.
[Is] ISSN:1556-9535
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:CONTEXT: Adenoviral conjunctivitis. OBJECTIVE: To examine the effects of conjunctival irrigation with povidone iodine in infants with adenoviral conjunctivitis. MATERIAL AND METHODS: An outbreak of adenovirus conjunctivitis occurred between September and December 2012 at the neonatal intensive care unit of our hospital. Forty-three infants with adenoviral conjunctivitis were examined in this study. Thirty-five eyes of 35 infants who had detailed ophthalmological examination and clinical scoring were included. The conjunctiva of 15 infants (Group 1) were irrigated with povidone iodine 2.5% solution and then treated with preservative-free artificial tears and preservative-free antibiotic drops. Twenty infants (Group 2) were treated only with the same drops with the same posology, without conjunctival irrigation with povidone iodine. Patients were examined two times a week until the complete recovery. Lid edema, conjunctival chemosis, fragility of conjunctival vasculature, pseudomembrane formation, and corneal involvement were scored clinically. RESULTS: Twenty patients (57%) were female and 15 patients (43%) were male and mean age was 3.1 months (ranged from 1 to 4 months). No relation was found between gender and clinical scores. Statistically significant lower clinical scores were obtained from Group 1. The median recovery time was earlier in Group 1 (7 d) than Group 2 (12 d) (p = 0.001). CONCLUSION: Conjunctival irrigation with 2.5% povidone iodine is effective in the treatment of adenoviral conjunctivitis in infants.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.3109/15569527.2014.888077

  5 / 13141 MEDLINE  
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[PMID]: 25785750
[Au] Autor:Lee S; Nolte H; Benninger MS
[Ad] Address:University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
[Ti] Title:Clinical considerations in the use of sublingual immunotherapy for allergic rhinitis.
[So] Source:Am J Rhinol Allergy;29(2):106-14, 2015 Mar.
[Is] ISSN:1945-8932
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Allergen immunotherapy (AIT) has been in practice for more than 100 years. However, research in novel routes and delivery methods of immunotherapy to treat allergic rhinitis (AR) and conjunctivitis has only recently occurred in the United States, where the predominant form of AIT provided is largely via a subcutaneous immunotherapy (SCIT) route. AIT may prevent new sensitizations, improve symptoms, decrease medication usage, and prevent allergic asthma. Although AIT is the only potentially curative treatment for AR, access and adherence continue to be problematic. Only a fraction of eligible patients actually undergo treatment, and attrition rates are high. An obvious limitation of SCIT includes the requirement of regular injections to be provided in the physician's office due to the potential for anaphylaxis. Sublingual immunotherapy (SLIT) for home administration has been investigated as a potential alternative to address this limitation of SCIT. METHODS: A literature review was performed including the current findings from randomized clinical trials and meta-analyses with a discussion of the most recent evidence for the efficacy, safety, and dosing of allergen SLIT. RESULTS: The current data suggest that SLIT is effective for treatment of seasonal allergies, can potentially prevent asthma, and has a favorable safety profile. Head-to-head studies, however, are few, and comparative effectiveness still remains to be answered. Optimal treatment algorithms for SLIT have not yet been established, with wide variation in dosage selection and schedules. Similarly to SCIT, only a few allergens such as ragweed and grass pollen have been found to be effective in large clinical trials. CONCLUSION: Recent data indicate that SLIT is an effective treatment modality for seasonal AR, improve quality of life, and can potentially prevent asthma but head-to head studies comparing SLIT to SCIT are needed.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.2500/ajra.2015.29.4148

  6 / 13141 MEDLINE  
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[PMID]: 25785742
[Au] Autor:Yenigun A; Dadaci Z; Oncel M
[Ad] Address:Konya Hospital, Otorhinolaryngology Clinic, Konya, Turkey.
[Ti] Title:Plasma vitamin D levels of patients with allergic rhino-conjunctivitis with positive skin prick test.
[So] Source:Am J Rhinol Allergy;29(2):46-9, 2015 Mar.
[Is] ISSN:1945-8932
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Allergic rhino-conjunctivitis (ARC) and allergic rhinitis are inflammatory diseases that develop through immunoglobulin E in the rhino-ocular mucosa due to allergy. The main symptoms are runny nose, nasal congestion, sneezing, itchy nose, and conjunctivitis. OBJECTIVE: This study was designed to evaluate plasma 25-hydroxyvitamin D levels in patients with ARC. STUDY DESIGN: This study was planned as a prospective and cross sectional study. This study was performed in a tertiary referral center. METHODS: This observational study involved 42 patients with ARC and 35 consecutive, age- and sex-matched healthy subjects. Patients in both groups underwent skin-prick test. Plasma 25-hydroxyvitamin D levels of all subjects were quantified with electrochemiluminescence technique. Results were compared between the groups and p < 0.05 was considered as statistically significant. RESULTS: Group one included 42 ARC patients (15 male, 27 female, ages between 12 and 43, average age 25.7 ± 8.6); group two included 35 healthy people (15 male, 20 female, ages between 12 and 44, average age 26.9 ± 9.1). Plasma 25-hydroxyvitamin D levels of the subjects with ARC group (7.33 ± 3.61 ng/mL, standard error mean: 0.55, range 3.17-13.68 ng/mL) were significantly lower than the control group (13.37 ± 5.42 ng/mL, standard error mean: 0.91, range 6.84-25.92 ng/mL) (p = 0.010, Independent-Samples test). CONCLUSIONS: We found lower plasma vitamin D levels in patients with ARC when compared with the control group.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.2500/ajra.2015.29.4164

  7 / 13141 MEDLINE  
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[PMID]: 25788949
[Au] Autor:Kim H; Waserman S; Hébert J; Blaiss M; Nelson H; Creticos P; Kaur A; Maloney J; Li Z; Nolte H
[Ad] Address:McMaster University, Hamilton, ON Canada ; Western University, London, ON Canada ; 525 Belmont Ave West, Suite 205, Kitchener, ON N2M 5E2 Canada....
[Ti] Title:Efficacy and safety of ragweed sublingual immunotherapy in Canadian patients with allergic rhinoconjunctivitis.
[So] Source:Allergy Asthma Clin Immunol;10(1):55, 2014.
[Is] ISSN:1710-1484
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Currently accepted therapies for ragweed allergy in North America consist of pharmacotherapy and subcutaneous allergen immunotherapy injections to treat symptoms. Allergen immunotherapy not only reduces symptoms and the need for pharmacotherapy but has also been shown to have disease-modifying potential. Recently, ragweed immunotherapy administered via sublingual allergen tablet has been approved in North America for treatment of allergic rhinitis with and without conjunctivitis. METHODS: This was an analysis of pooled data for a prespecified subgroup of Canadian subjects from two multicentre, randomized, double-blind placebo-controlled trials of ragweed sublingual tablet (SLIT-T; 6 and 12 Amb a 1-U of Ambrosia artemisiifolia) in patients aged ≥18y, with ragweed-induced allergic rhinoconjunctivitis (AR/C) with or without asthma. Randomized subjects used once-daily ragweed SLIT-T or placebo for at least 12 weeks before the ragweed season and for up to 52 weeks post-randomization. The primary efficacy endpoint was the total combined score (TCS) based on the sum of AR/C daily symptom score (DSS) and daily medication score (DMS) averaged over the peak season. Treatment effects on TCS, DSS, and DMS in the entire season were also assessed. Adverse events (AEs) were monitored to assess safety. RESULTS: 337 Canadian subjects were randomized in the two trials. During the peak season, ragweed SLIT-T 6 and 12 Amb a 1-U significantly reduced TCS by 26% (difference, -2.46 score point; p = .0009) and 40% (difference, -3.75 score point; p < .0001), respectively. In the overall population (N = 961), TCS reductions with 6 and 12 Amb a 1-U were 20% and 23%, respectively (both p < .001). Clinically meaningful reductions in entire-season TCS in Canadians were similar to those during peak ragweed season. Dose-dependent reduction of DSS and DMS was also observed for ragweed SLIT-T 6 and 12 Amb a 1-U during the peak season and the entire season. Ragweed SLIT-T was well tolerated in Canadian subjects and the overall population. Adverse events were generally mild to moderate and transient, occurring early in treatment; no systemic allergic reaction/anaphylaxis was noted. CONCLUSION: Ragweed SLIT-T is an effective form of immunotherapy that provides symptomatic efficacy of AR/C with a favorable risk profile in Canadian and overall populations. TRIAL REGISTRATION: Clinicaltrials.gov identifiers NCT00783198 and NCT00770315.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Da] Date of entry for processing:150319
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1186/1710-1492-10-55

  8 / 13141 MEDLINE  
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[PMID]: 25569311
[Au] Autor:Liu X; Kuriyan AE; Amescua G
[Ad] Address:Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, Florida.
[Ti] Title:A painful red eye.
[So] Source:JAMA Ophthalmol;133(1):95-6, 2015 Jan.
[Is] ISSN:2168-6173
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Conjunctivitis/diagnosis
Eye Pain/diagnosis
Granulomatosis with Polyangiitis/diagnosis
Scleritis/diagnosis
[Mh] MeSH terms secundary: Administration, Oral
Adult
Antibodies, Antineutrophil Cytoplasmic/blood
Biopsy
Glucocorticoids/therapeutic use
Granulomatosis with Polyangiitis/drug therapy
Humans
Immunosuppressive Agents/therapeutic use
Male
Methotrexate/therapeutic use
Microscopy, Acoustic
Prednisone/therapeutic use
Referral and Consultation
Scleritis/drug therapy
Sinusitis/diagnosis
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Antibodies, Antineutrophil Cytoplasmic); 0 (Glucocorticoids); 0 (Immunosuppressive Agents); VB0R961HZT (Prednisone); YL5FZ2Y5U1 (Methotrexate)
[Em] Entry month:1503
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:150109
[St] Status:MEDLINE
[do] DOI:10.1001/jamaophthalmol.2014.3888

  9 / 13141 MEDLINE  
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[PMID]: 25232655
[Au] Autor:Vora GK; Marr B; Cummings TJ; Mruthyunjaya P
[Ad] Address:Department of Cornea and Refractive Surgery, Duke Eye Center, Durham, North Carolina....
[Ti] Title:Conjunctival pseudotumor caused by herpes simplex virus infection.
[So] Source:JAMA Ophthalmol;133(1):105-7, 2015 Jan.
[Is] ISSN:2168-6173
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Conjunctivitis, Viral/virology
Eye Infections, Viral/virology
Herpes Simplex/virology
Simplexvirus/isolation & purification
[Mh] MeSH terms secundary: Administration, Oral
Administration, Topical
Adult
Anti-Bacterial Agents/therapeutic use
Antiviral Agents/therapeutic use
Azithromycin/therapeutic use
Conjunctival Neoplasms/diagnosis
Conjunctival Neoplasms/virology
Conjunctivitis, Viral/diagnosis
Conjunctivitis, Viral/drug therapy
Diagnosis, Differential
Drug Therapy, Combination
Eye Infections, Viral/diagnosis
Eye Infections, Viral/drug therapy
Female
Ganciclovir/therapeutic use
HIV Infections/diagnosis
Hepatitis C/diagnosis
Herpes Simplex/diagnosis
Herpes Simplex/drug therapy
Humans
Male
Middle Aged
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Bacterial Agents); 0 (Antiviral Agents); 83905-01-5 (Azithromycin); P9G3CKZ4P5 (Ganciclovir)
[Em] Entry month:1503
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:150109
[St] Status:MEDLINE
[do] DOI:10.1001/jamaophthalmol.2014.3316

  10 / 13141 MEDLINE  
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[PMID]: 25580738
[Au] Autor:Chiang MR; Wei CC; Muo CS; Fu LS; Li TC; Kao CH
[Ad] Address:Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan....
[Ti] Title:Association of primary immune thrombocytopenia and common allergic diseases among children.
[So] Source:Pediatr Res;77(4):597-601, 2015 Apr.
[Is] ISSN:1530-0447
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Growing evidence has revealed a link between autoimmune and allergic diseases. However, few studies have assessed the relationship between allergic diseases and primary immune thrombocytopenia (ITP), an autoimmune disease frequently occurring in children. This population-based case-control study investigated the association between common allergic diseases and the subsequent risk of developing ITP during childhood. METHODS: This study investigated 1,203 children younger than 18 y of age who were diagnosed with ITP between 1998 and 2008, as well as 4,812 frequency-matched controls. The odds ratios of the association between ITP and preexisting allergic diseases were calculated. RESULTS: Children with every type of allergic disease examined in this study (except asthma) exhibited an increased risk of developing ITP; the lowest adjusted odds ratio (aOR) was 1.39 for allergic conjunctivitis (95% confidence interval (CI) = 1.09-1.79), whereas the greatest aOR was 1.84 for allergic rhinitis (95% CI = 1.49-2.27). The aORs increased with the number of concurrent allergic diseases to 2.89 (95% CI = 1.98-4.22) for children with at least three allergic diseases. CONCLUSION: Children with atopic diathesis have a greater risk of subsequently developing ITP. The fundamental determinants of this relationship warrant further study.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1038/pr.2015.6


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