Database : MEDLINE
Search on : Conjunctivitis [Words]
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[PMID]: 25312466
[Au] Autor:Yang C; Jin M
[Ad] Address:Beijing University of Chinese Medicine, China-Japan Friendship Hospital, Beijing 100029, China.
[Ti] Title:[Epidemics of conjunctivitis caused by avian influenza virus and molecular basis for its ocular tropism].
[So] Source:Zhonghua Yan Ke Za Zhi;50(7):550-2, 2014 Jul.
[Is] ISSN:0412-4081
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:Avian influenza virus (AIV) has caused several outbreaks in humans, leading to disasters to human beings. The outbreak of H7N9 avian influenza in China in 2003 re-attracted our close attention to this disease. More and more evidences demonstrated that eye is one of invasion portals of AIV, leading to conjunctivitis. The current studies showed that only subtypes H7 and H5 could cause severe systemic infections. Abundant distribution of α-2, 3 siliac acid receptor in conjunctiva and cornea as well as specific activiation of NF-κB signal transduction pathway by subtype H7 virus may contribute to the ocular tropism of the virus. These studies suggest that avian influenza conjunctivitis should be considered as a differential diagnosis during influenza epidemic seasons, and eyes should be well protected for disease control personnel when handling avian influenza epidemics. This review focused on AIV conjunctivitis and the molecular basis of ocular tropism.
[Mh] MeSH terms primary: Conjunctivitis, Viral/epidemiology
Influenza A Virus, H5N1 Subtype
Influenza A Virus, H7N9 Subtype
[Mh] MeSH terms secundary: Animals
China/epidemiology
Conjunctivitis, Viral/virology
Eye/virology
Humans
Influenza A Virus, H5N1 Subtype/physiology
Influenza A Virus, H7N9 Subtype/physiology
Influenza, Human/epidemiology
Influenza, Human/virology
Orthomyxoviridae Infections/epidemiology
Orthomyxoviridae Infections/virology
Tropism
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1505
[Js] Journal subset:IM
[Da] Date of entry for processing:141014
[St] Status:MEDLINE

  2 / 13212 MEDLINE  
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[PMID]: 25769661
[Au] Autor:Kennedy DP; Chandler JW; McCulley JP
[Ad] Address:Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9057, United States.
[Ti] Title:Ocular surface involvements in ectrodactyly-ectodermal dysplasia-cleft syndrome.
[So] Source:Cont Lens Anterior Eye;38(3):228-31, 2015 Jun.
[Is] ISSN:1476-5411
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:PURPOSE: To present the ocular manifestation of 2 cases of ectrodactyly-ectodermal dysplasia-cleft syndrome, a multiple congenital anomaly syndrome caused by a single point mutation of the p63 gene that controls epidermal development and homeostasis and to present treatment options. CASE REPORTS AND DISCUSSION: Patient 1 presented with mild signs and symptoms of dry eye and limbal stem cell deficiency with retention of 20/30 vision. Patient 2 presented with severe signs and symptoms of limbal stem cell deficiency with diffuse corneal scarring and counting fingers vision. This second patient's course was complicated by allergic conjunctivitis and advanced steroid-induced glaucoma. The cause of visual loss in ectrodactyly-ectodermal dysplasia-cleft syndrome appears to be multifactorial and likely includes inflammation of the ocular surface, tear film abnormalities, eyelid abnormalities, and limbal stem cell deficiency. Treatment modalities including lubrication, contact lenses, and limbal stem cell transplantation are reviewed. CONCLUSIONS: The ophthalmic conditions seen in ectrodactyly-ectodermal dysplasia-cleft syndrome frequently lead to vision loss. Early correct diagnosis and appropriate therapy are paramount because p63 gene mutations have a critical role in maintaining the integrity of the ocular surface in the setting of limbal stem cell deficiency, especially if there are other ocular surface insults such as lid disease, meibomian gland dysfunction and toxicity from topical medications. Patients should be monitored at regular, frequent intervals; and particular attention should be taken to avoid adverse secondary effects of these conditions and medications.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Js] Journal subset:IM
[St] Status:In-Data-Review

  3 / 13212 MEDLINE  
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[PMID]: 25684056
[Au] Autor:Ackoundou-N'Guessan C; Coulibaly N; Guei CM; Aye D; N'guessan FY; N'Dah JK; Lagou DA; Tia MW; Coulibaly PA; Nzoue S; Konan S; Gnionsahe DA
[Ad] Address:Service de néphrologie et hémodialyse, CHU de Yopougon, Abidjan, Côte d'Ivoire. Electronic address: cnackoundoun66@hotmail.fr....
[Ti] Title:Cystite hémorragique à adénovirus chez le transplanté rénal: à propos d'un premier cas en Afrique noire survenu dans un tout débutant programme de greffe rénale et revue de la littérature. [Hemorrhagic cystitis due to adenovirus in a renal transplant recipient: the first reported case in black Africa in a setting of a very beginning of a kidney transplantation program and review of the literature].
[So] Source:Nephrol Ther;11(2):104-10, 2015 Apr.
[Is] ISSN:1872-9177
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:Viral infections are an important complication of transplantation. Polyomavirus are the commonest viruses that infect the renal allograft. Herpes virus nephropathy has also been described. In the past 15 years, adenovirus nephritis has emerged as a potentially life-threatening disease in renal transplant patients in developed countries. Most of the papers devoted to adenovirus nephritis are reported cases. The fate of such patients in resources-limited countries is not known. Herein, we describe the clinical, biological and prognostic findings of a black African transplanted patient with adenoviral hemorrhagic cystitis. This case is the very first of its kind reported in black Africa in a setting of a start of a renal transplantation pilot project. The patient is a 54-year-old man admitted at the nephrology service for gross haematuria and fever occurred 1 month after kidney transplantation. The diagnosis of adenoviral hemorrhagic cystitis has been suspected because the patient has displayed recurrent conjunctivitis and gastroenteritis well before transplantation, which was then confirmed by the real-time polymerase chain reaction performed on the blood. Conservatory measures associated with immunosuppression reduction have permitted the discontinuation of haematuria. This case has been discussed in regard of the epidemiology, the diagnosis, the treatment, the evolution and the prognosis of the adenoviral infection in the renal transplant patient. A review of the literature has been performed subsequently.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Process

  4 / 13212 MEDLINE  
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[PMID]: 25168823
[Au] Autor:Pallavi R; Popescu-Martinez A
[Ad] Address:Department of Internal Medicine, New York Medical College and Metropolitan Hospital Center, New York, New York, USA.
[Ti] Title:More than meets the eye: the 'pink salmon patch'.
[So] Source:BMJ Case Rep;2014, 2014.
[Is] ISSN:1757-790X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Ocular adnexal lymphomas account for 1-2% of all non-Hodgkin's lymphomas. Conjunctiva is the primary site of involvement in one-third of cases. We present a case of a 47-year-old Hispanic woman who presented with left eye itching and irritation associated with a painless pink mass. Physical examination revealed the presence of a 'pink salmon-patch' involving her left medial conjunctiva. Orbital CT showed a subcentimeter left preseptal soft tissue density. Biopsy revealed a dense subepithelial lymphoid infiltrate comprised predominantly of B cells that did not coexpress CD5 or CD43. These findings were consistent with B-cell marginal zone lymphoma. Further staging assessment did not reveal disseminated disease. She had stage 1E extranodal marginal zone lymphoma as per Ann Arbor staging system. She received external beam radiotherapy to her left eye with complete resolution of the lymphoma in 2 months and continues to remain tumour free at 8-month follow-up. She will be followed up closely for development of any local (unilateral or contralateral eye) or systemic recurrence in the long run.
[Mh] MeSH terms primary: Conjunctival Neoplasms/pathology
Lymphoma, B-Cell, Marginal Zone/pathology
[Mh] MeSH terms secundary: Conjunctival Neoplasms/radiography
Conjunctival Neoplasms/radiotherapy
Conjunctivitis/diagnosis
Diagnosis, Differential
Female
Follow-Up Studies
Humans
Lymphoma, B-Cell, Marginal Zone/radiography
Lymphoma, B-Cell, Marginal Zone/radiotherapy
Middle Aged
Treatment Outcome
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1505
[Js] Journal subset:IM
[Da] Date of entry for processing:140829
[St] Status:MEDLINE

  5 / 13212 MEDLINE  
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[PMID]: 25115683
[Au] Autor:Gomes PJ
[Ad] Address:Department of Allergy, Ora, Inc, Andover, Massachusetts, USA.
[Ti] Title:Trends in prevalence and treatment of ocular allergy.
[So] Source:Curr Opin Allergy Clin Immunol;14(5):451-6, 2014 Oct.
[Is] ISSN:1473-6322
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE OF REVIEW: This review describes recent findings and trends in prevalence and treatment of allergic ocular diseases. Although the major focus is on seasonal and perennial allergic conjunctivitis, related disorders will also be considered. RECENT FINDINGS: Published reports from countries around the world suggest that the spectrum of atopic diseases, including seasonal and perennial allergic conjunctivitis, is continuing its pattern of increasing prevalence, which has been well documented over the past few decades. In addition, although treatment modalities have focused on topical formulations including antihistamines and corticosteroids, there is a significant emphasis on immunotherapy as an alternative treatment modality, particularly in the USA. SUMMARY: Allergic conjunctivitis is a key component in the spectrum of allergic diseases that is sometimes collectively referred to as rhinoconjunctivitis. Because of its high prevalence worldwide, it exacts an increasing toll in terms of patient discomfort, morbidity, and loss of productivity. Current estimates suggest that at least 20% of the overall population suffers from some form of allergic conjunctivitis, many without ever seeking treatments. In addition, a significant proportion of patients experience chronic forms of allergy that are less responsive to existing therapies. Recent approval of immunotherapy-based treatments may address this therapeutic gap.
[Mh] MeSH terms primary: Adrenal Cortex Hormones/therapeutic use
Conjunctivitis, Allergic/therapy
Histamine Antagonists/therapeutic use
Immunotherapy/methods
Rhinitis, Allergic, Perennial/therapy
Rhinitis, Allergic, Seasonal/therapy
[Mh] MeSH terms secundary: Administration, Topical
Conjunctivitis, Allergic/epidemiology
Humans
Prevalence
Rhinitis, Allergic, Perennial/epidemiology
Rhinitis, Allergic, Seasonal/epidemiology
United States
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Adrenal Cortex Hormones); 0 (Histamine Antagonists)
[Em] Entry month:1505
[Js] Journal subset:IM
[Da] Date of entry for processing:140823
[St] Status:MEDLINE
[do] DOI:10.1097/ACI.0000000000000100

  6 / 13212 MEDLINE  
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[PMID]: 25102104
[Au] Autor:Syed BA; Kumar S; Bielory L
[Ad] Address:aIMS Health Limited, London, UK bRobert Wood Johnson University Hospital, Rutgers University, New Brunswick, New Jersey, USA.
[Ti] Title:Current options and emerging therapies for anterior ocular inflammatory disease.
[So] Source:Curr Opin Allergy Clin Immunol;14(5):485-9, 2014 Oct.
[Is] ISSN:1473-6322
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE OF REVIEW: Ophthalmic disorders are highly prevalent in the United States, with approximately 3.5 million individuals aged at least 40 either blind or having impaired vision. This article reviews the current leading agents and pipeline therapies for the treatment of anterior ocular inflammatory disease (AOID). RECENT FINDINGS: There has been great progress in the understanding of ocular pathophysiology in recent years. Although current treatments for AOID are effective and well tolerated in many patients, a continued demand persists for more efficacious alternatives to the limited modalities available to clinicians. SUMMARY: Several promising modalities for AOID, particularly for allergic conjunctivitis, immune treatments for uveitis and dry eye syndrome are in late-stage development that could offer optimal treatment paradigm once available in the clinic.
[Mh] MeSH terms primary: Anti-Infective Agents/therapeutic use
Antibodies, Monoclonal/therapeutic use
Conjunctivitis, Allergic/drug therapy
Cyclosporine/therapeutic use
Dry Eye Syndromes/therapy
Immunotherapy/trends
Uveitis, Anterior/drug therapy
[Mh] MeSH terms secundary: Chemokine CCL11/immunology
Clinical Trials as Topic
Dibenzoxepins/therapeutic use
Fluoroquinolones/therapeutic use
Histamine H1 Antagonists/therapeutic use
Humans
Levofloxacin/therapeutic use
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Anti-Infective Agents); 0 (Antibodies, Monoclonal); 0 (Chemokine CCL11); 0 (Dibenzoxepins); 0 (Fluoroquinolones); 0 (Histamine H1 Antagonists); 6GNT3Y5LMF (Levofloxacin); 83HN0GTJ6D (Cyclosporine); D27V6190PM (olopatadine); U188XYD42P (moxifloxacin)
[Em] Entry month:1505
[Js] Journal subset:IM
[Da] Date of entry for processing:140823
[St] Status:MEDLINE
[do] DOI:10.1097/ACI.0000000000000097

  7 / 13212 MEDLINE  
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[PMID]: 25061855
[Au] Autor:Dartt DA; Masli S
[Ad] Address:aDepartment of Ophthalmology, Schepens Eye Research Institute/Massachusetts Eye and Ear, Harvard Medical School bDepartment of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, USA.
[Ti] Title:Conjunctival epithelial and goblet cell function in chronic inflammation and ocular allergic inflammation.
[So] Source:Curr Opin Allergy Clin Immunol;14(5):464-70, 2014 Oct.
[Is] ISSN:1473-6322
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE OF REVIEW: Although conjunctival goblet cells are a major cell type in ocular mucosa, their responses during ocular allergy are largely unexplored. This review summarizes the recent findings that provide key insights into the mechanisms by which their function and survival are altered during chronic inflammatory responses, including ocular allergy. RECENT FINDINGS: Conjunctiva represents a major component of the ocular mucosa that harbors specialized lymphoid tissue. Exposure of mucin-secreting goblet cells to allergic and inflammatory mediators released by the local innate and adaptive immune cells modulates proliferation, secretory function, and cell survival. Allergic mediators like histamine, leukotrienes, and prostaglandins directly stimulate goblet cell mucin secretion and consistently increase goblet cell proliferation. Goblet cell mucin secretion is also detectable in a murine model of allergic conjunctivitis. Additionally, primary goblet cell cultures allow evaluation of various inflammatory cytokines with respect to changes in goblet cell mucin secretion, proliferation, and apoptosis. These findings in combination with the preclinical mouse models help understand the goblet cell responses and their modulation during chronic inflammatory diseases, including ocular allergy. SUMMARY: Recent findings related to conjunctival goblet cells provide the basis for novel therapeutic approaches, involving modulation of goblet cell mucin production, to improve treatment of ocular allergies.
[Mh] MeSH terms primary: Conjunctiva/immunology
Conjunctivitis, Allergic/immunology
Goblet Cells/immunology
[Mh] MeSH terms secundary: Animals
Apoptosis/immunology
Cell Proliferation
Chronic Disease
Cytokines/metabolism
Disease Models, Animal
Humans
Immunity, Mucosal
Inflammation/immunology
Mice
Mucins/secretion
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; REVIEW
[Nm] Name of substance:0 (Cytokines); 0 (Mucins)
[Em] Entry month:1505
[Js] Journal subset:IM
[Da] Date of entry for processing:140823
[St] Status:MEDLINE
[do] DOI:10.1097/ACI.0000000000000098

  8 / 13212 MEDLINE  
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[PMID]: 25054831
[Au] Autor:Erdinest N; Solomon A
[Ad] Address:Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
[Ti] Title:Topical immunomodulators in the management of allergic eye diseases.
[So] Source:Curr Opin Allergy Clin Immunol;14(5):457-63, 2014 Oct.
[Is] ISSN:1473-6322
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE OF REVIEW: Allergic eye diseases comprise a spectrum of diseases, with each condition being characterized by a complex immunopathology. The more severe and chronic conditions, such as vernal keratoconjunctivitis and atopic keratoconjunctivitis, involve predominantly mast cells and eosinophils, while also being associated with a preponderance of T cells. Treatment with topical antihistamines or mast cell stabilizers is often unsatisfactory, and therapy depends on topical corticosteroids. Corticosteroids have significant side-effects with long-term use; therefore, they appear to be more appropriate for short-term pulse therapy. Immunomodulatory agents can also be used to inhibit T-cell activation and show encouraging results among patients with severe allergic eye conditions. The present review is an attempt to present a coherent picture of the recent investigations of topical immunomodulatory agents' therapy in severe allergic eye diseases, especially cyclosporine A and tacrolimus, and their mechanisms of action. RECENT FINDINGS: Immunomodulatory agents are commonly indicated for the treatment of severe and prolonged allergic conjunctivitis. This article reviews the recent studies of these drugs and the development of immunomodulatory treatments for severe allergic eye diseases. SUMMARY: Cyclosporine A and tacrolimus are currently available for the treatment of severe allergic conjunctivitis. These agents have led to improved therapeutic results for patients with severe and chronic allergic eye diseases.
[Mh] MeSH terms primary: Conjunctivitis, Allergic/drug therapy
Cyclosporine/therapeutic use
Eye/drug effects
T-Lymphocytes/drug effects
Tacrolimus/therapeutic use
[Mh] MeSH terms secundary: Administration, Topical
Adrenal Cortex Hormones/therapeutic use
Conjunctivitis, Allergic/immunology
Eosinophils/drug effects
Eosinophils/immunology
Eye/immunology
Eye/pathology
Humans
Immunomodulation
Lymphocyte Activation/drug effects
Mast Cells/drug effects
Mast Cells/immunology
T-Lymphocytes/immunology
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Name of substance:0 (Adrenal Cortex Hormones); 83HN0GTJ6D (Cyclosporine); WM0HAQ4WNM (Tacrolimus)
[Em] Entry month:1505
[Js] Journal subset:IM
[Da] Date of entry for processing:140823
[St] Status:MEDLINE
[do] DOI:10.1097/ACI.0000000000000089

  9 / 13212 MEDLINE  
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[PMID]: 25970112
[Au] Autor:Lahiri K; Landge A; Gahlowt P; Bhattar A; Rai R
[Ad] Address:Department of Pediatrics, D Y Patil Hospital and Research Centre, Nerul, India.
[Ti] Title:Phlyctenular conjunctivitis and tuberculosis.
[So] Source:Pediatr Infect Dis J;34(6):675, 2015 Jun.
[Is] ISSN:1532-0987
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1097/INF.0000000000000628

  10 / 13212 MEDLINE  
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SciELO Brazil full text

[PMID]: 25714075
[Au] Autor:Dreyfuss JL; Regatieri CV; Coelho B; Barbosa JB; De Freitas D; Nader HB; Martins JR
[Ad] Address:Departamento de Bioquímica, Universidade Federal de São Paulo, São Paulo, SP, Brasil....
[Ti] Title:Altered hyaluronic acid content in tear fluid of patients with adenoviral conjunctivitis.
[So] Source:An Acad Bras Cienc;87(1):455-62, 2015 Mar.
[Is] ISSN:1678-2690
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:The adenoviral conjunctivitis is one of the biggest causes of conjunctival infection in the world. Conjunctivitis causes relatively nonspecific symptoms, as hyperaemia and chemosis. Even after biomicroscopy, complex laboratory tests, such as viral culture, are necessary to identify the pathogen or its etiology. To contribute to the better understanding of the pathobiology of the adenoviral conjunctivitis, the tear fluids of patients with unilateral acute adenovirus conjunctivitis (UAAC), normal donors (control) and patients with allergic conjunctivitis were analyzed. Tear samples were collected with Schirmer strips from control, allergic conjunctivitis and UAAC patients, diagnosed by clinical signs. UAAC tears were tested positive in viral cultures. After the elution, HA was quantified using an ELISA-like fluorometric assay and the protein profile was determined by SDS-PAGE. A profound increase in the HA tear content in UAAC patients was found when compared to control and ALC. This HA increase in UAAC tears remarkably was not observed in tears from contralateral eyes without clinical signs, nor in allergic conjunctivitis. In addition a distinct profile of UAAC tear proteins was observed in patients with UAAC. The quantification of HA in the tear fluid is a rapid, sensitive and specific test. This molecule might be a biomarker candidate for acute conjunctivitis.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Process


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