Database : MEDLINE
Search on : Conjunctivitis [Words]
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[PMID]: 24953451
[Au] Autor:Sugita G; Hotomi M; Sugita R; Kono M; Togawa A; Yamauchi K; Funaki T; Yamanaka N
[Ad] Address:Department of Otolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan....
[Ti] Title:Genetic characteristics of Haemophilus influenzae and Streptococcus pneumoniae isolated from children with conjunctivitis-otitis media syndrome.
[So] Source:J Infect Chemother;20(8):493-7, 2014 Aug.
[Is] ISSN:1437-7780
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Acute conjunctivitis is the most common ocular disorders among children and frequently concomitant with acute otitis media (AOM) as conjunctivitis-otitis syndrome. In this study, we evaluated prevalence of causative pathogens and PCR-based genotypes of Haemophilus influenzae and Streptococcus pneumoniae among children with conjunctivitis-otitis media syndrome. Nontypeable H. influenzae (NTHi) is identified most often at 61.8% in conjunctiva exudates followed by S. pneumoniae at 28.2% and Moraxella catarrhalis at 19.1%. Genetic ß-lactamase nonproducing ampicillin resistant (gBLNAR) strains of NTHi and genetic penicillin resistant S. pneumoniae (gPRSP) were identified at 72.1% and at 74.2% among conjunctiva isolates by polymerase chain reaction (PCR), respectively. Pneumococcal strains having either ermB or mefE genes were identified at 93.5% among conjunctiva isolates. The restriction fragment of patterns of 89.7% pairs of H. influenzae isolates and 100% pairs of pneumococcal isolates from conjunctiva exudates, middle ear fluids (MEFs) and nasopharyngeal swabs were identical. In contrast to the previous reports, most prevalent strains from conjunctivitis-otitis media syndrome was BLNAR H. influenzae in this study. The causative pathogen responsible for acute conjunctivitis will be originated from the nasopharynx. In the absence of MEFs one can possibly rely on the nasopharyngeal culture to guide an appropriate treatment.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review

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[PMID]: 24118571
[Au] Autor:Tappe D; Mueller A; Weißbrich B; Schubert J; Schargus M; Stich A
[Ad] Address:Institute of Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
[Ti] Title:Severe conjunctivitis due to multidrug-resistant Neisseria gonorrhoeae and adenovirus 53 coinfection in a traveler returning from Thailand.
[So] Source:J Travel Med;20(6):403-6, 2013 Nov-Dec.
[Is] ISSN:1708-8305
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:A male traveler returning from Thailand with severe bilateral conjunctivitis was tested for causative pathogens by culture and polymerase chain reaction in late 2010. The culturally grown Neisseria gonorrhoeae strain was resistant against penicillin, ciprofloxacin, and tetracycline. The patient was also found to have an eye infection with the unusual and likely recombinant adenovirus type 53. Besides multidrug-resistant gonococcal strains the unusual adenovirus strain is found circulating in Asia and both pathogens may be a risk for travelers.
[Mh] MeSH terms primary: Adenoviridae Infections/ethnology
Adenoviridae/isolation & purification
Conjunctivitis/ethnology
Drug Resistance, Multiple
Eye Infections, Bacterial/ethnology
Gonorrhea/ethnology
Travel
[Mh] MeSH terms secundary: Adenoviridae Infections/complications
Adenoviridae Infections/virology
Adult
Coinfection
Conjunctivitis/microbiology
Conjunctivitis/virology
Eye Infections, Bacterial/microbiology
Germany/epidemiology
Gonorrhea/microbiology
Humans
Male
Neisseria gonorrhoeae/isolation & purification
Thailand/ethnology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[Da] Date of entry for processing:131029
[St] Status:MEDLINE
[do] DOI:10.1111/jtm.12071

  3 / 12858 MEDLINE  
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[PMID]: 25015496
[Au] Autor:Jubelt B; Lipton HL
[Ad] Address:Departments of Neurology, Microbiology/Immunology and Neuroscience, SUNY Upstate Medical University, Syracuse, NY, USA. Electronic address: jubeltb@upstate.edu.
[Ti] Title:Enterovirus/Picornavirus infections.
[So] Source:Handb Clin Neurol;123:379-416, 2014.
[Is] ISSN:0072-9752
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:The human enteroviruses (EV) comprise one group of the picornavirus family. The best known members are the polioviruses (PV), coxsackieviruses, and echoviruses. They replicate in the oropharynx and gastrointestinal (GI) tract and are primarily spread by fecal-hand-oral contamination. With systemic invasion nonspecific febrile illness occurs as well as specific syndromes (rashes, hand-foot-and-mouth disease, herpangina, pleurodynia, myocarditis/pericarditis, and conjunctivitis). With systemic replication a high level viremia may result in central nervous system (CNS) invasion. EV activity can be endemic in warm climates or epidemic in temperate climates. In temperate climates, because of improved hygiene, newborns were not exposed to EV until they were older, resulting in large epidemics of poliomyelitis, which were finally curtailed with the killed PV vaccines in the 1950s and the live oral PV vaccines in the 1960s. Today, "aseptic" meningitis is the most common neurologic syndrome caused by EV. EV are also the most common cause of viral meningitis. Other EV neurologic syndromes include encephalitis, paralytic disease, persistent infections, and the severe group B coxsackievirus fatal systemic infections of neonates. Newly recognized emerging infections include EV71 rhombencephalitis/brainstem encephalitis and saffold virus (Saf V) meningitis and cerebellitis. Diagnostic clues can come from epidemics, systemic manifestations, household infections, the cerebrospinal fluid picture, and the neurologic syndromes. However, definite diagnosis depends on laboratory methods, primarily nucleic acid amplification. Treatment of acute infections is supportive. Preventive methods include good hygiene and aggressive polio vaccination programs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review

  4 / 12858 MEDLINE  
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[PMID]: 24886618
[Au] Autor:Yamagishi T; Ochi N; Yamane H; Hasebe S; Takigawa N
[Ti] Title:Epiphora in lung cancer patients receiving docetaxel: a case series.
[So] Source:BMC Res Notes;7:322, 2014.
[Is] ISSN:1756-0500
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Docetaxel is a key antineoplastic drug for treatment of non-small cell lung cancer. Ocular adverse events of docetaxel include epiphora (excess tearing) and conjunctivitis. Epiphora has been reported to be associated with canalicular and nasolacrimal duct stenosis, but it is not necessarily caused by lacrimal duct obstruction. CASE PRESENTATION: We encountered three Japanese non-small cell lung cancer patients who developed epiphora after the administration of docetaxel-based chemotherapy. One patient with lacrimal puncta stenosis showed improvement with probing and irrigation. The other two patients resolved following cessation of docetaxel or administration of artificial tears. CONCLUSION: As epiphora can interfere with activities of daily life and negatively affect quality of life, it is important for thoracic oncologists to be aware of this adverse event.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1406
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1186/1756-0500-7-322

  5 / 12858 MEDLINE  
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[PMID]: 23971648
[Au] Autor:Berger VW; Gudehithlu SK
[Ad] Address:National Cancer Institute and University of Maryland Baltimore County, Biometry Research Group, National Cancer Institute , 9609 Medical Center Drive, Rockville, MD 20850 , USA.
[Ti] Title:Re: Compalati E, Canonica GW. Efficacy and safety of rupatadine for allergic rhino-conjunctivitis: a systematic review of randomized, double-blind, placebo-controlled studies with meta-analysis. Letter to the editor.
[So] Source:Curr Med Res Opin;29(11):1553-4, 2013 Nov.
[Is] ISSN:1473-4877
[Cp] Country of publication:England
[La] Language:eng
[Mh] MeSH terms primary: Conjunctivitis, Allergic/drug therapy
Cyproheptadine/analogs & derivatives
Histamine Antagonists/therapeutic use
Rhinitis, Allergic, Perennial/drug therapy
Rhinitis, Allergic, Seasonal/drug therapy
[Mh] MeSH terms secundary: Cyproheptadine/therapeutic use
Humans
[Pt] Publication type:COMMENT; LETTER
[Nm] Name of substance:0 (Histamine Antagonists); 2AE8M83G3E (rupatadine); 2YHB6175DO (Cyproheptadine)
[Em] Entry month:1407
[Js] Journal subset:IM
[Da] Date of entry for processing:131017
[St] Status:MEDLINE
[do] DOI:10.1185/03007995.2013.837386

  6 / 12858 MEDLINE  
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[PMID]: 23826741
[Au] Autor:Compalati E; Canonica GW
[Ad] Address:Allergy and Respiratory Diseases Clinic, Dept of Internal Medicine, University of Genoa, IRCCS AOU San Martino-IST , Genoa , Italy.
[Ti] Title:Efficacy and safety of rupatadine for allergic rhino-conjunctivitis: a systematic review of randomized, double-blind, placebo-controlled studies with meta-analysis.
[So] Source:Curr Med Res Opin;29(11):1539-51, 2013 Nov.
[Is] ISSN:1473-4877
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Allergic rhinitis is a complex inflammatory disease whose pathophysiology involves local and systemic mechanisms. Rupatadine, a molecule with intense antihistaminic activity and with antagonist PAF effects through its interaction with specific receptors, is indicated for the treatment of intermittent or persistent allergic rhinitis and urticaria. SCOPE: This systematic review was aimed at identifying in the most important databases, up to January 2013, the double-blind placebo-controlled randomized trials administering rupatadine in allergic rhinitis. No restriction was introduced for treatment duration and dose, study design, population age, allergen exposition and disease classification. The methodological quality of included studies and risk of bias were systematically assessed. Meta-analysis was performed when possible to summarize information. FINDINGS: Seventeen of 413 initially identified records were fully assessed for eligibility. Ten trials involving 2573 patients overall met the inclusion criteria and entered the analysis. Their internal validity was satisfactory. Data synthesis showed that rupatadine is superior to placebo in relieving the overall allergy symptoms on reflective (SMD: -0.37, 95% CI -0.46 to -0.27; p < 0.00001) and instantaneous (SMD: -0.41, 95% CI -0.71 to -0.11; p = 0.007) assessment, the nasal symptoms considered together (reflective SMD: -0.36, 95% CI -0.48 to -0.25; p < 0.00001; instantaneous SMD: -0.39, 95% CI -0.61 to -0.17; p = 0.0004) or individually and ocular symptoms. Inter-study heterogeneity was low for the main outcomes and the risk of publication bias was judged as unlikely. A number of secondary endpoints were favorably affected by rupatadine. No difference was observed in the incidence of total adverse reactions between rupatadine and placebo (OR 1.23, 95% CI 0.95 to 1.59; p = 0.12). CONCLUSION: Randomized double-blind controlled trials show a favorable risk-benefit ratio in rupatadine for the treatment of allergic rhino-conjunctivitis. This evidence is strengthened when data are pooled in the form of meta-analysis, where accurate and robust effect estimations are derived from a large population.
[Mh] MeSH terms primary: Conjunctivitis, Allergic/drug therapy
Cyproheptadine/analogs & derivatives
Histamine Antagonists/therapeutic use
Rhinitis, Allergic, Perennial/drug therapy
Rhinitis, Allergic, Seasonal/drug therapy
[Mh] MeSH terms secundary: Cyproheptadine/adverse effects
Cyproheptadine/therapeutic use
Histamine Antagonists/adverse effects
Humans
Platelet Activating Factor/antagonists & inhibitors
Treatment Outcome
Urticaria/drug therapy
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Name of substance:0 (Histamine Antagonists); 0 (Platelet Activating Factor); 2AE8M83G3E (rupatadine); 2YHB6175DO (Cyproheptadine)
[Em] Entry month:1407
[Js] Journal subset:IM
[Da] Date of entry for processing:131017
[St] Status:MEDLINE
[do] DOI:10.1185/03007995.2013.822855

  7 / 12858 MEDLINE  
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[PMID]: 24028473
[Au] Autor:Ibáñez MD; Valero AL; Montoro J; Jauregui I; Ferrer M; Dávila I; Bartra J; Del Cuvillo A; Mullol J; Sastre J
[Ad] Address:Allergy Section, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
[Ti] Title:Analysis of comorbidities and therapeutic approach for allergic rhinitis in a pediatric population in Spain.
[So] Source:Pediatr Allergy Immunol;24(7):678-84, 2013 Nov.
[Is] ISSN:1399-3038
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Allergic rhinitis (AR) is the most common chronic disease in children. The main objective of this study was to analyze the comorbidities and therapeutic approaches for AR in a Spanish pediatric population. METHODS: Children aged 6 to 12 years with AR were included in an observational, cross-sectional, multicenter study. RESULTS: 1,275 children were recruited from 271 centers. AR was intermittent in 59.5% of cases, persistent in 40.5%, seasonal in 60.7%, and perennial in 39.3% of patients. The most frequent comorbidities were conjunctivitis (53.6%), asthma (49.5%), atopic dermatitis (40%), rhinosinusitis(26.1%), otitis media (23.8%), and adenoid hypertrophy (17.3%). Overall, patients with persistent, moderate or severe, AR were more likely to present comobidities, except for food allergy and urticaria. The most common drugs used for treatment of AR were oral antihistamines(76%), nasal corticosteroids(49%) and a combination of both (45%). Antihistamines and nasal corticosteroids were used on demand (<18 days) in 38 and 41% of patients, respectively; for 18-30 days in 22 and 27%; for 1-3 months in 31 and 29%; and for more than 3 months in 8 and 3%, respectively. Eye drops were used in 32% and specific immunotherapy in 21% of patients. CONCLUSION: Comorbidities are frequent in children with AR, supporting the notion of allergy as a systemic disease. Severity and duration of AR were significantly associated with presence of most of comorbidities. The most common drugs used for AR treatment were oral antihistamines, followed by nasal corticosteroids and a combination of both used on demand.
[Mh] MeSH terms primary: Asthma/epidemiology
Conjunctivitis/epidemiology
Dermatitis, Atopic/epidemiology
Rhinitis, Allergic, Perennial/epidemiology
Rhinitis, Allergic, Seasonal/epidemiology
[Mh] MeSH terms secundary: Administration, Intranasal
Administration, Oral
Adrenal Cortex Hormones/therapeutic use
Child
Chronic Disease
Comorbidity
Cross-Sectional Studies
Drug Therapy, Combination
Female
Histamine Antagonists/therapeutic use
Humans
Male
Rhinitis, Allergic, Perennial/drug therapy
Rhinitis, Allergic, Seasonal/drug therapy
Spain
[Pt] Publication type:JOURNAL ARTICLE; MULTICENTER STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Adrenal Cortex Hormones); 0 (Histamine Antagonists)
[Em] Entry month:1407
[Js] Journal subset:IM
[Da] Date of entry for processing:131011
[St] Status:MEDLINE
[do] DOI:10.1111/pai.12126

  8 / 12858 MEDLINE  
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[PMID]: 23968667
[Au] Autor:Sánchez G; Nova J
[Ad] Address:Centro Dermatológico Federico Lleras Acosta, E.S.E, Bogotá D.C., Colombia. Electronic address: guillermosanchezvanegas@gmail.com.
[Ti] Title:Risk factors for squamous cell carcinoma, a study by the National Dermatology Centre of Colombia.
[So] Source:Actas Dermosifiliogr;104(8):672-8, 2013 Oct.
[Is] ISSN:1578-2190
[Cp] Country of publication:Spain
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Nonmelanoma skin cancer is the most common malignancy in white individuals. The risk factors for squamous cell carcinoma, which belongs to the family of nonmelanoma skin cancers, have not been studied in Colombia. OBJECTIVE: To determine the risk factors for squamous cell carcinoma in patients at a national referral center for skin diseases in Colombia. MATERIAL AND METHODS: We conducted a case-control study that evaluated sociodemographic, epidemiological, and clinical factors among 332 individuals. Risk was calculated as odds ratio (ORs) using the multivariate conditional logistic regression analysis method. RESULTS: The following risk factors were identified: family history of skin cancer (OR, 6.55; 95% CI, 1.4-28.9), living in a rural area after the age of 30 years (OR, 3.13; 95% CI, 1.3-7.2), a lifetime working outdoors (OR, 2.98; 95% CI, 1.5-5.7), smoking more than 10 cigarettes a day (OR, 2.96; 95% CI, 1.3-6.5), actinic conjunctivitis (OR, 2.68; 95% CI, 1.2-5.9), poikiloderma of Civatte (OR, 3.29; 95% CI, 1.7-6.1), numerous facial actinic keratoses (OR, 9.23; 95% CI, 4.9-17.1), and numerous freckles (OR, 3.68; 95% CI, 1.3-10.1). CONCLUSIONS: We have documented clinical characteristics and personal history factors that should guide the physician in making decisions on the preventive and follow-up measures to be adopted for individuals at risk of squamous cell carcinoma. These findings may help guide policy for controlling the disease using local information.
[Mh] MeSH terms primary: Carcinoma, Squamous Cell/epidemiology
Skin Neoplasms/epidemiology
[Mh] MeSH terms secundary: Adult
Aged
Aged, 80 and over
Arsenicals/adverse effects
Case-Control Studies
Colombia/epidemiology
Facial Dermatoses/epidemiology
Female
Humans
Keratosis, Actinic/epidemiology
Male
Melanosis/epidemiology
Middle Aged
Neoplasms, Radiation-Induced/epidemiology
Occupations/statistics & numerical data
Protective Clothing/utilization
Questionnaires
Risk Factors
Rural Population/statistics & numerical data
Smoking/epidemiology
Socioeconomic Factors
Sunlight/adverse effects
Sunscreening Agents
Tertiary Care Centers/statistics & numerical data
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Arsenicals); 0 (Sunscreening Agents)
[Em] Entry month:1407
[Js] Journal subset:IM
[Da] Date of entry for processing:130926
[St] Status:MEDLINE

  9 / 12858 MEDLINE  
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[PMID]: 24906343
[Au] Autor:Ecochard-Dugelay E; Beliah M; Perreaux F; de Laveaucoupet J; Bouyer J; Epaud R; Labrune P; Ducou-Lepointe H; Gajdos V
[Ti] Title:Clinical predictors of radiographic abnormalities among infants with bronchiolitis in a paediatric emergency department.
[So] Source:BMC Pediatr;14:143, 2014.
[Is] ISSN:1471-2431
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Acute viral respiratory exacerbation is one of the most common conditions encountered in a paediatric emergency department (PED) during winter months. We aimed at defining clinical predictors of chest radiography prescription and radiographic abnormalities, among infants with bronchiolitis in a paediatric emergency department. METHODS: We conducted a prospective cohort study of children less than 2 years of age with clinical bronchiolitis, who presented for evaluation at the paediatric emergency department of an urban general hospital in France. Detailed information regarding historical features, examination findings, and management were collected. Clinical predictors of interest were explored in multivariate logistic regression models. RESULTS: Among 410 chest radiographs blindly interpreted by two experts, 40 (9.7%) were considered as abnormal. Clinical predictors of chest radiography achievement were age (under three months), feeding difficulties, fever over 38°C, hypoxia under than 95% of oxygen saturation, respiratory distress, crackles, and bronchitis rales. Clinical predictors of radiographic abnormalities were fever and close to significance hypoxia and conjunctivitis. CONCLUSION: Our study provides arguments for reducing chest radiographs in infants with bronchiolitis. For infants with clinical factors such as age less than three months, feeding difficulties, respiratory distress without hypoxia, isolated crackles or bronchitis rales, careful clinical follow-up should be provided instead of chest radiography.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1406
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1186/1471-2431-14-143

  10 / 12858 MEDLINE  
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[PMID]: 24809415
[Au] Autor:Doi H; Kunikata H; Kato K; Nakazawa T
[Ad] Address:Department of Ophthalmology, Graduate School of Medicine, Tohoku University, Sendai, Japan....
[Ti] Title:Ophthalmologic examinations in areas of miyagi prefecture affected by the great East Japan earthquake.
[So] Source:JAMA Ophthalmol;132(7):874-6, 2014 Jul 1.
[Is] ISSN:2168-6173
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:IMPORTANCE: One month after the Great East Japan Earthquake on March 11, 2011, our clinic was granted free use of the Mission Vision Van, a customized bus airlifted to Japan. This mobile eye clinic made it possible for us to provide ophthalmologic examinations anywhere in the disaster zone in Miyagi Prefecture. OBSERVATIONS: This study included 731 patients who received treatment in the eye care van in Miyagi Prefecture between April 15 and May 29, 2011. We examined and cared for patients during 25 visits to 11 emergency districts during 15 clinic days. Of the 914 diagnoses we identified, 358 were refractive disorders (39.2%), which were the most common ocular diseases we observed; others included 155 (17.0%) cataracts, 106 (11.6%) dry eye, and 73 (8.0%) infectious diseases, such as conjunctivitis. Overall, we provided emergency prescriptions for 871 bottles of eyedrops comprising 222 prescriptions (25.5%) for dry eye, 189 (21.7%) for cataracts, and 107 (12.3%) for glaucoma. CONCLUSIONS AND RELEVANCE: A substantial number of patients in the earthquake-damaged areas needed replacements for eyeglasses, contact lenses, and eyedrops. The mobile clinic appears to be a useful way to provide ophthalmologic examinations and support after a disaster.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.1001/jamaophthalmol.2014.849


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