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[PMID]: 25128381
[Au] Autor:Su W; Wan Q; Han L; Huang J; Chen X; Chen G; Zheng SG; Liang D
[Ad] Address:State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China; Clinic Immunology Section, Sun Yat-sen University Third Affiliated Hospital, Guangzhou, China....
[Ti] Title:Doxycycline exerts multiple anti-allergy effects to attenuate murine allergic conjunctivitis and systemic anaphylaxis.
[So] Source:Biochem Pharmacol;91(3):359-68, 2014 Oct 1.
[Is] ISSN:1873-2968
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Allergic diseases, which affect up to 20-30% of the world population, are still therapeutic challenge for allergists. Tetracyclines, which belong to an antibiotic drug family that possesses a striking variety of non-antibiotic properties, have been successfully applied to a wide range of diseases. However, their roles in allergic conjunctivitis and anaphylaxis and their underlying anti-allergy mechanisms remain elusive. Here, we reported that treatment with doxycycline significantly reduced IgE release from mouse B cells and the degranulation and inflammatory cytokines production of mouse mast cells (MCs) activated by IgE-dependent way. Furthermore, doxycycline treatment significantly inhibited histamine-induced vascular hyperpermeability in vitro. Mechanistically, the doxycycline-mediated inhibition of B cells, MCs and histamine may occur via modulation of the PI3K/Akt pathway. In vivo, our results demonstrated that treatment with doxycycline significantly attenuated clinical symptoms of mouse models of experimental allergic conjunctivitis (EAC) with a significant decrease in inflammatory cell frequency, IgE production, histamine release, and a decrease in TNF-α and IL-4 production. Using mouse models of MCs-dependent passive systemic anaphylaxis (PSA), we further confirmed anti-allergy effects of doxycycline and doxycycline-mediated inhibitory effects on MCs. Furthermore, our results showed that doxycycline significantly attenuate histamine-induced systemic anaphylaxis-like reaction (HISA) with a significantly downregulation of PI3K/Akt/eNOS/VE-cadherin pathway. The doxycycline-mediated anti-allergy effects during EAC, PSA and HISA were abrogated when an Akt activator, SC79, was administered. These findings suggest that doxycycline inhibits B cell, MC and histamine function and attenuates experimental allergic conjunctivitis and systemic anaphylaxis by possible modulating the PI3K/Akt pathway.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

  2 / 12934 MEDLINE  
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[PMID]: 24916929
[Au] Autor:Eperon S; Berguiga M; Ballabeni P; Guex-Crosier C; Guex-Crosier Y
[Ad] Address:Ocular Immunology, Jules Gonin Eye Hospital, University of Lausanne, 15, Av. de France, 1000, Lausanne 7, Switzerland, simone.eperon@fa2.ch.
[Ti] Title:Total IgE and eotaxin (CCL11) contents in tears of patients suffering from seasonal allergic conjunctivitis.
[So] Source:Graefes Arch Clin Exp Ophthalmol;252(9):1359-67, 2014 Sep.
[Is] ISSN:1435-702X
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:BACKGROUND: To prospectively investigate patients with seasonal allergic conjunctivitis (SAC) during the pollen season and test associations between tears total IgE, eotaxin concentrations, and SAC severity. METHODS: Enrolled patients presented ocular symptoms and clinical signs of SAC at the time of presentation. Ocular itching, hyperaemia, chemosis, eyelid swelling, and tearing were scored, and the sum of these scores was defined as the clinical score. Conjunctival papillae were separately graded. We measured eotaxin concentration in tears by an enzyme-linked immunosorbent assay (ELISA) and total tear IgE by Lacrytest strip. RESULTS: Among thirty patients (30 eyes), 11 showed neither tear IgE nor tear eotaxin, while 15 out of 19 patients with positive IgE values presented a positive amount of eotaxin in their tears (Fisher's test: p < 0.001). The mean eotaxin concentration was 641 ± 154 (SEM) pg/ml. In patients with no amount of tear IgE, we observed a lower conjunctival papilla grade than in patients whose tears contained some amount of IgE (trend test: p = 0.032). In the 15 patients whose tear eotaxin concentration was null, tear IgE concentration was 5.3 ± 3.5 arbitrary units; in the other 15 patients whose eotaxin was positive, IgE reached 21 ± 4.3 arbitrary U (Mann-Whitney: p < 0.001). We measured 127 ± 47 pg/ml eotaxin in patients with no history of SAC but newly diagnosed as suffering from SAC, and 852 ± 218 pg/ml eotaxin in patients with a known SAC (p = 0.008). In contrast, tear IgE concentrations of both groups did not differ statistically significantly (p = 0.947). CONCLUSIONS: If IgE and eotaxin secreted in tears are major contributors in SAC pathogenesis, they however act at different steps of the process.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00417-014-2683-6

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[PMID]: 25183929
[Au] Autor:Gelaw Y; Abateneh A
[Ad] Address:Department of Ophthalmology, Jimma University, Ethiopia.
[Ti] Title:Ocular Morbidity among Refugees in Southwest Ethiopia.
[So] Source:Ethiop J Health Sci;24(3):227-34, 2014 Jul.
[Is] ISSN:1029-1857
[Cp] Country of publication:Ethiopia
[La] Language:eng
[Ab] Abstract:BACKGROUND: Low vision and blindness are recognized as one of the major public health problems worldwide, especially in developing countries. The prevalence and cause of blindness and low vision vary from region to region, among different age and population groups in a country or geographical region. The objective of this study is thus to determine the causes of blindness and ocular morbidity among refugees in Southwest Ethiopia. METHODS: A cross-sectional clinic based study was conducted on 1,054 refugees in Southwest Ethiopia. A basic anterior and posterior segment examination was done by ophthalmologists with Magnifying Loupe 2.5X and Direct Ophthalmoscope. Data were analyzed using SPSS version 16.0. RESULTS: The most common causes of ocular morbidity identified were trachoma 547(21.2%), cataract 501(19.4%), refractive error 353(13.7%), conjunctivitis 240(9.3%), glaucoma 130(5.1%) and climatic droplet keratopathy 112(4.4%). The overall prevalence of blindness was 26.2% and the prevalence of childhood blindness was 0.7%. The prevalence was higher among females (16.9%) than males (9.3%) and age groups 60 years and above (15.9%) than other age groups (10.3%) (P<0.05). The overall prevalence of low vision was 25.8% and the prevalence of low vision in pediatric age group was 0.9%. The leading causes of blindness were cataract 112(40.6%), trachomatous corneal opacity 58(21.0%) and glaucoma 49(17.8%). The commonest cause of low vision was cataract 102(37.6%) followed by trachomatous corneal opacity 49(18.1%) and refractive error 35(12.9%). CONCLUSIONS: There is a very high burden of blinding eye diseases among refugees. Integrated multidisciplinary intervention strategies for the prevention and control of blindness and low vision in the study settings should be initiated.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

  4 / 12934 MEDLINE  
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[PMID]: 23725348
[Au] Autor:Murphy K; Gawchik S; Bernstein D; Andersen J; Pedersen MR
[Ti] Title:A phase 3 trial assessing the efficacy and safety of grass allergy immunotherapy tablet in subjects with grass pollen-induced allergic rhinitis with or without conjunctivitis, with or without asthma.
[So] Source:J Negat Results Biomed;12:10, 2013.
[Is] ISSN:1477-5751
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Design and execution of immunotherapy trials for seasonal allergies may be complicated by numerous factors including variable allergy testing methods, pollen levels, and timing and intensity of other seasonal allergens. We evaluated grass allergy immunotherapy tablet (AIT) treatment in North American adults with grass pollen-induced allergic rhinitis with or without conjunctivitis (AR/C), with/without asthma. METHODS: Subjects age 18-65 with clinical history of grass pollen-induced AR/C, with/without asthma were randomized 1:1 to once-daily 2800 BAU Timothy grass AIT (oral lyophilisate, Phleum pratense, 75,000 SQ-T, containing approximately 15 µg of Phl p 5) or placebo. The AR/C symptom and medication scores were recorded daily. The primary end point was the average AR/C daily symptom score (DSS) during the entire grass pollen season (GPS). Ranked key secondary end points were Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) score, daily medication score (DMS), and percentage of well days, all over entire GPS. Safety was monitored through adverse event reporting. RESULTS: Efficacy analysis included 289 subjects. Over the entire GPS, mean DSS was 6% lower with AIT versus placebo (5.69 vs. 6.06), but this difference was not statistically significant (p = 0.3475) despite significantly higher immunological response in the grass AIT group. No significant between-group differences were seen for key secondary end points. In general, DSS was high before GPS began and no clear relationship between DSS and grass pollen counts was seen during GPS. In post hoc analysis of subjects with pre-seasonal DSS ≤3, mean DSS and DMS were both significantly lower with grass AIT versus placebo (27%; p = 0.0327 and 68%; p = 0.0060, respectively). In this subgroup a relationship between DSS and grass pollen counts was observed. Grass AIT was generally well tolerated, with no events of anaphylactic shock or respiratory compromise. CONCLUSIONS: In this trial, 2800 BAU grass AIT did not demonstrate significant symptom improvement versus placebo. Lack of relationship between pollen count and symptom score in the study population, and post hoc findings among subjects with low pre-seasonal symptoms, suggest that the symptoms reported in this study were not primarily reflective of the effects of grass pollen exposure. TRIAL REGISTRATION: NCT00421655.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1407
[Js] Journal subset:IM
[Cl] Clinical Trial:ClinicalTrial
[St] Status:In-Process
[do] DOI:10.1186/1477-5751-12-10

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[PMID]: 25000933
[Au] Autor:Wong AH; Barg SS; Leung AK
[Ti] Title:Seasonal and perennial allergic conjunctivitis.
[So] Source:Recent Pat Inflamm Allergy Drug Discov;8(2):139-53, 2014.
[Is] ISSN:1872-213X
[Cp] Country of publication:United Arab Emirates
[La] Language:eng
[Ab] Abstract:Seasonal and perennial allergic conjunctivitis are IgE-mediated, hypersensitivity conditions characterized by ocular pruritus, epiphora, and hyperemia. Proper diagnosis is usually made clinically based on history and physical examination. Diagnostic procedures are rarely necessary. Non-pharmacological measures, such as environmental modification and proper eye care, should be considered for all patients with allergic conjunctivitis. Pharmacological interventions may also be required. Milder cases can be treated with short-term topical ophthalmic therapy such as a decongestant/ antihistamine combination, a mast cell stabilizer, or a multi-action agent. Moderate to severe cases may require longer usage of the above agents and/or the addition of an oral antihistamine. Refractory cases may necessitate the use of topical ophthalmic corticosteroids and topical NSAIDs. Immunotherapy, whether via the subcutaneous route or the intranasal route, should be considered in the treatment of persistent severe cases refractory to conventional treatment. Despite all the available therapeutic agents, there continues to be a constant need to discover more effective ways to treat seasonal and perennial allergic conjunctivitis. This article also discusses recent patents related to the field.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Process

  6 / 12934 MEDLINE  
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[PMID]: 24235317
[Au] Autor:Garg L; Dauwels J; Earnest A; Leong KP
[Ti] Title:Tensor-Based Methods for Handling Missing Data in Quality-of-Life Questionnaires.
[So] Source:IEEE J Biomed Health Inform;18(5):1571-80, 2014 Sep.
[Is] ISSN:2168-2208
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:A common problem with self-report quality-of-life questionnaires is missing data. Despite enormous care and effort to prevent it, some level of missing data is common and unavoidable. Missing data can have a detrimental impact on the data analysis. In this paper, a novel approach to imputing missing data in quality-of-life questionnaires is proposed, based on matrix and tensor decompositions. In order to illustrate and assess those methods, two datasets are considered: The first dataset contains the responses of 100 patients to a systemic lupus erythematosus-specific quality-of-life questionnaire; the other contains the responses of 43 patients to a rhino-conjunctivitis quality-of-life questionnaire. The two datasets contain almost no missing data, and for testing purposes, data entries are removed at random to have missing completely at random data. Several proportions of missing values are considered, and for each, the imputation error is assessed through k-fold cross validation. We also evaluate different imputation methods for missing at random and missing not at randomdata. The numerical results demonstrate that the proposed tensor factorization-based methods outperform standard methods in terms of root mean square error with at least 4% improvement, while the bias and variance are similar.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1109/JBHI.2013.2288803

  7 / 12934 MEDLINE  
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[PMID]: 25183103
[Au] Autor:Hayleeyesus SF; Manaye AM
[Ad] Address:Department of Environmental Health Science and Technology, College of Public Health and Medical Science, Jimma University, Ethiopia.
[Ti] Title:Microbiological quality of indoor air in university libraries.
[So] Source:Asian Pac J Trop Biomed;4(Suppl 1):S312-7, 2014 May.
[Is] ISSN:2221-1691
[Cp] Country of publication:China
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To evaluate the concentration of bacteria and fungi in the indoor environment of Jimma University libraries, so as to estimate the health hazard and to create standards for indoor air quality control. METHODS: The microbial quality of indoor air of eight libraries of Jimma University was determined. The settle plate method using open Petri-dishes containing different culture media was employed to collect sample twice daily. Isolates were identified according to standard methods. RESULTS: The concentrations of bacteria and fungi aerosols in the indoor environment of the university libraries ranged between 367-2595 CFU/m(3). According to the sanitary standards classification of European Commission, almost all the libraries indoor air of Jimma University was heavily contaminated with bacteria and fungi. In spite of their major source difference, the average fungi density found in the indoor air of libraries did appear to follow the same trend with bacterial density (P=0.001). The bacteria isolates included Micrococcus sp., Staphylococcus aureus, Streptococcus pyogenes, Bacillus sp. and Neisseria sp. while Cladosporium sp., Alternaria sp., Penicillium sp. and Aspergillus sp. were the most isolated fungi. CONCLUSIONS: The indoor air of all libraries were in the range above highly contaminated according to European Commission classification and the most isolates are considered as potential candidates involved in the establishment of sick building syndromes and often associated with clinical manifestations like allergy, rhinitis, asthma and conjunctivitis. Thus, attention must be given to control those environmental factors which favor the growth and multiplication of microbes in indoor environment of libraries to safeguard the health of users and workers.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Cu] Class update date: 140905
[Lr] Last revision date:140905
[Da] Date of entry for processing:140903
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.12980/APJTB.4.2014C807

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[PMID]: 25186606
[Au] Autor:Cuppari C; Leonardi S; Manti S; Filippelli M; Alterio T; Spicuzza L; Rigoli L; Arrigo T; Lougaris V; Salpietro C
[Ad] Address:Department of Pediatrics, Unit of Pediatric Genetics & Immunology, University of Messina, Italy.
[Ti] Title:Allergen immunotherapy, routes of administration and cytokine networks: an update.
[So] Source:Immunotherapy;6(6):775-86, 2014 Jun.
[Is] ISSN:1750-7448
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Allergen immunotherapy is a disease-modifying therapy, effective for the treatment of allergic rhinitis, allergic asthma, conjunctivitis or stinging insect allergy. Allergen immunotherapy involves the administration of increasing doses of allergens with the aim of ameliorating the allergic response. Although precise underlying mechanisms of the induction of immune tolerance remain unclear, immunotherapy has been associated with the induction of distinct subsets of Tregs that eventually lead to peripheral tolerance by inducing a deviation from Th2 to Th1 immune responses. This review focuses on the current knowledge of the mechanisms of immunotherapy in relationship to different routes of administration and also provides a unifying view.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.2217/imt.14.47

  9 / 12934 MEDLINE  
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[PMID]: 25161470
[Au] Autor:Okesola AO; Salako AO
[Ad] Address:Department of Medical Microbiology and Parasitology, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria.
[Ti] Title:Microbiological profile of bacterial conjunctivitis in ibadan, Nigeria.
[So] Source:Ann Ib Postgrad Med;8(1):20-4, 2010 Jun.
[Is] ISSN:1597-1627
[Cp] Country of publication:Nigeria
[La] Language:eng
[Ab] Abstract:OBJECTIVE: In bacterial conjunctivitis, clinical presentations are not diagnostic of the causative agent, therefore, microbiological analysis is mandatory for specific treatment option. This study was undertaken to determine the microbiology profile of bacterial conjunctivitis in our environment. METHODOLOGY: This is a laboratory-based study carried out in the Medical Microbiology Laboratory of University College Hospital, Ibadan, Nigeria. Conjunctival swabs collected from 365 patients with clinically diagnosed conjunctivitis, were analysed by standard bacteriological methods. RESULTS: Bacterial pathogens were detected in 342 (93.7%) conjunctival samples while 23(6.3%) were sterile. Of the pathogens, 256 (74.9%) were Staphylococcus aureus, 35(10.2%) Coagulase- negative staphylococci, 22 (6.4%) Pseudomonas aeruginosa , 11(3.2%) Escherichia coli, 7(2.1%) Klebsiella species, 5(1.5%) Streptococcus pneumoniae , 4(1.2%) Haemophilus influenzae, 1(0.3%) Proteus mirabilis, and 1(0.3%)Neisseria gonorrhoeae. The highest rate of conjunctivitis 96(26.3%) was found among infants and children (0-10years).Resistance rates to most of the tested antibiotics were high. However, 67% of them were susceptible to ceftriaxone while only 39.2% were susceptible to chloramphenicol. CONCLUSION: This study has recorded high antibiotic resistance in bacterial pathogens of conjunctivitis in this environment; therefore, determining the susceptibility pattern of these pathogens to available antibiotics is crucial to effective management of bacterial conjunctivitis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Cu] Class update date: 140904
[Lr] Last revision date:140904
[Da] Date of entry for processing:140827
[St] Status:PubMed-not-MEDLINE

  10 / 12934 MEDLINE  
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[PMID]: 25056074
[Au] Autor:Fujimoto T; Yamane S; Ogawa T; Hanaoka N; Ogura A; Hotta C; Niwa T; Chiba Y; Gonzalez G; Aoki K; Koyanagi KO; Watanabe H
[Ad] Address:National Institute of Infectious Diseases.
[Ti] Title:A novel complex recombinant form of type 48-related human adenovirus species D isolated in Japan.
[So] Source:Jpn J Infect Dis;67(4):282-7, 2014.
[Is] ISSN:1884-2836
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:Recently, new genotypes of human adenoviruses (HAdVs) have been reported and many of them have been found to be recombinant forms of different known types of HAdV species D (HAdV-D). The objective of this study was to document the evolutionary features of a novel isolate (HAdV_Chiba_E086/2012) obtained from the eye swab of a patient with conjunctivitis in Japan. Viral DNA was extracted from the isolate to sequence the whole genome by the Sanger method and aligned with available genome sequences of HAdV-Ds. The phylogenetic trees of the nucleotide sequences of the penton base, hexon, and fiber genes and the E3 region showed that HAdV_Chiba_E086/2012 is closest to HAdV genotype 65 (HAdV-GT65), HAdV-48, HAdV-GT60 and HAdV-22 at 98%, 99%, 95% and 98% identity, respectively, suggesting that this isolate is a novel recombinant form to be designated as P65H48F60. Further phylogenetic and recombination analyses of the genome alignment of the new isolate implied that nested recombination events involving HAdV-GT59, GT65, 48, GT60, 22, and some ancestral lineages or their close relatives have shaped its genome. These results showed that HAdV_Chiba_E086/2012 is the first HAdV-48-related HAdV found in Japan, which has the most complicated evolutionary history among the known HAdVs so far.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Process


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