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[PMID]: 26147920
[Au] Autor:Kraiwong N; Sanyathitiseree P; Boonprasert K; Diskul P; Charoenphan P; Pintawong W; Thayananuphat A
[Ad] Address:Graduate School, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom, 73140, Thailand....
[Ti] Title:Anterior ocular abnormalities of captive Asian elephants (Elephas maximus indicus) in Thailand.
[So] Source:Vet Ophthalmol;19(4):269-74, 2016 Jul.
[Is] ISSN:1463-5224
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To survey and classify anterior ocular abnormalities in 1478 captive Asian elephants (Elephas maximus indicus) in six regions of Thailand. METHODS: Anterior ocular examination was performed in both eyes (n = 2956) of 1478 elephants selected from the annual health check program involving 2958 animals within six regions of Thailand from January to November 2013. Lesions were described and compared between age and gender. RESULTS: A total of 17.83% (527/2956) of examined eyes from 24.97% (369/1478) of examined elephants had anterior ocular abnormalities. The most common lesions in these examined eyes were frothy ocular discharge (5.85%), corneal edema (5.31%), and conjunctivitis (5.18%). In addition, epiphora, phthisis bulbi, other corneal abnormalities, anterior uveitis, and lens abnormalities were noted. Almost all lesions increased in frequency with age (P < 0.01). CONCLUSIONS: Regular ophthalmic examination in elephants should be included in their annual health check program. Early detection and treatment of any ocular abnormality may avoid the development of subsequent irreversible ocular pathology.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1607
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/vop.12296

  2 / 13813 MEDLINE  
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[PMID]: 27070847
[Au] Autor:Cerbino-Neto J; Mesquita EC; Souza TM; Parreira V; Wittlin BB; Durovni B; Lemos MC; Vizzoni A; Bispo de Filippis AM; Sampaio SA; Gonçalves Bde S; Bozza FA
[Ti] Title:Clinical Manifestations of Zika Virus Infection, Rio de Janeiro, Brazil, 2015.
[So] Source:Emerg Infect Dis;22(7):1318-20, 2016 Jul.
[Is] ISSN:1080-6059
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1606
[Cu] Class update date: 160701
[Lr] Last revision date:160701
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.3201/eid2207.160375

  3 / 13813 MEDLINE  
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[PMID]: 27279226
[Au] Autor:Cugola FR; Fernandes IR; Russo FB; Freitas BC; Dias JL; Guimarães KP; Benazzato C; Almeida N; Pignatari GC; Romero S; Polonio CM; Cunha I; Freitas CL; Brandão WN; Rossato C; Andrade DG; Faria Dde P; Garcez AT; Buchpigel CA; Braconi CT; Mendes E; Sall AA; Zanotto PM; Peron JP; Muotri AR; Beltrão-Braga PC
[Ad] Address:University of São Paulo, Department of Surgery, Stem Cell Laboratory, São Paulo, São Paulo 05508-270, Brazil....
[Ti] Title:The Brazilian Zika virus strain causes birth defects in experimental models.
[So] Source:Nature;534(7606):267-71, 2016 Jun 9.
[Is] ISSN:1476-4687
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Zika virus (ZIKV) is an arbovirus belonging to the genus Flavivirus (family Flaviviridae) and was first described in 1947 in Uganda following blood analyses of sentinel Rhesus monkeys. Until the twentieth century, the African and Asian lineages of the virus did not cause meaningful infections in humans. However, in 2007, vectored by Aedes aegypti mosquitoes, ZIKV caused the first noteworthy epidemic on the Yap Island in Micronesia. Patients experienced fever, skin rash, arthralgia and conjunctivitis. From 2013 to 2015, the Asian lineage of the virus caused further massive outbreaks in New Caledonia and French Polynesia. In 2013, ZIKV reached Brazil, later spreading to other countries in South and Central America. In Brazil, the virus has been linked to congenital malformations, including microcephaly and other severe neurological diseases, such as Guillain-Barré syndrome. Despite clinical evidence, direct experimental proof showing that the Brazilian ZIKV (ZIKV(BR)) strain causes birth defects remains absent. Here we demonstrate that ZIKV(BR) infects fetuses, causing intrauterine growth restriction, including signs of microcephaly, in mice. Moreover, the virus infects human cortical progenitor cells, leading to an increase in cell death. We also report that the infection of human brain organoids results in a reduction of proliferative zones and disrupted cortical layers. These results indicate that ZIKV(BR) crosses the placenta and causes microcephaly by targeting cortical progenitor cells, inducing cell death by apoptosis and autophagy, and impairing neurodevelopment. Our data reinforce the growing body of evidence linking the ZIKV(BR) outbreak to the alarming number of cases of congenital brain malformations. Our model can be used to determine the efficiency of therapeutic approaches to counteracting the harmful impact of ZIKV(BR) in human neurodevelopment.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1606
[Cu] Class update date: 160701
[Lr] Last revision date:160701
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1038/nature18296

  4 / 13813 MEDLINE  
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[PMID]: 25907207
[Au] Autor:McAnena L; Knowles SJ; Curry A; Cassidy L
[Ad] Address:Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland....
[Ti] Title:Prevalence of gonococcal conjunctivitis in adults and neonates.
[So] Source:Eye (Lond);29(7):875-80, 2015 Jul.
[Is] ISSN:1476-5454
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:PURPOSE: To report the prevalence of gonococcal conjunctivitis (GC) presenting to a tertiary referral maternity hospital (NMH) and a tertiary referral ophthalmic hospital (RVEEH) from 2011 to 2013 and describe the demographics, clinical presentation, and antibiotic susceptibility of Neisseria gonorrhoeae ocular infections. METHODS: Demographic, clinical, and microbiological data were collected from patients with laboratory confirmed GC. RESULTS: There were 27 556 live births at NMH during the study period, and no case of neonatal GC was identified. Fourteen cases of GC were identified at RVEEH in this period, representing a prevalence of 0.19 cases per 1000 eye emergency attendees. Antibiotic susceptibility data were available on nine cases, of which, all were ceftriaxone- and ciprofloxacin sensitive. 64.3% of patients were male, with a mean age of 18 years. The mean duration of symptoms was 3 days. All patients presented with unilateral conjunctival injection and purulent discharge. Eight cases had visual impairment at presentation and their mean visual acuity was 6/15. Corneal involvement was present in 25% of patients. Uveitis was not detected. On receipt of positive culture and/or PCR results, treatment was altered in two thirds of patients. All patients were referred for full STI screening and all patients showed a full clinical recovery 1 week posttreatment. CONCLUSION: We observed that GC presented in young adults with a male predominance and was rare in neonates. In cases of unilateral purulent conjunctivitis, there should be a high clinical suspicion of GC, early swab for PCR and culture, and knowledge of current CDC-recommended antibiotic guidelines.
[Mh] MeSH terms primary: Conjunctivitis, Bacterial/epidemiology
Eye Infections, Bacterial/epidemiology
Gonorrhea/epidemiology
Neisseria gonorrhoeae/isolation & purification
Ophthalmia Neonatorum/diagnosis
Ophthalmia Neonatorum/epidemiology
[Mh] MeSH terms secundary: Adolescent
Anti-Bacterial Agents/therapeutic use
Ceftriaxone/therapeutic use
Child
Child, Preschool
Ciprofloxacin/therapeutic use
Conjunctivitis, Bacterial/diagnosis
Conjunctivitis, Bacterial/drug therapy
Eye Infections, Bacterial/diagnosis
Eye Infections, Bacterial/drug therapy
Female
Gonorrhea/diagnosis
Gonorrhea/drug therapy
Hospitals, Maternity/statistics & numerical data
Hospitals, Special/statistics & numerical data
Humans
Ireland/epidemiology
Male
Microbial Sensitivity Tests
Neisseria gonorrhoeae/drug effects
Ophthalmia Neonatorum/drug therapy
Ophthalmology/statistics & numerical data
Polymerase Chain Reaction
Prevalence
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Bacterial Agents); 5E8K9I0O4U (Ciprofloxacin); 75J73V1629 (Ceftriaxone)
[Em] Entry month:1601
[Cu] Class update date: 160701
[Lr] Last revision date:160701
[Js] Journal subset:IM
[Da] Date of entry for processing:150709
[St] Status:MEDLINE
[do] DOI:10.1038/eye.2015.57

  5 / 13813 MEDLINE  
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[PMID]: 27366760
[Au] Autor:Saxena SK; Elahi A; Gadugu S; Prasad AK
[Ad] Address:CSIR-Centre for Cellular and Molecular Biology (CCMB), Uppal Road, Hyderabad, TS 500007 India....
[Ti] Title:Zika virus outbreak: an overview of the experimental therapeutics and treatment.
[So] Source:Virusdisease;27(2):111-5, 2016 Jun.
[Is] ISSN:2347-3584
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Zika virus (ZIKV) infection is a new emerging threat around the globe which might be responsible for microcephaly and Guillain-Barre syndrome in the infants. Recently, ZIKV outbreak has caused a public health crisis in Brazil after being linked to a sharp increase in birth defects. ZIKV is ssRNA virus belongs to the family Flaviviridae. It is mainly transmitted by mosquito bite specifically Aedes species and disease symptoms include fever, joint pain, muscle pain, rash, conjunctivitis, and headache. The reservoir of ZIKV is still not known. Protection at personal level by avoiding mosquito bite would help to reduce the incidence of the disease. Control of ZIKV infection by vaccination or antiviral drug either from modern, complementary and alternative medicines may be considered to be one of the most effective strategies in the long run. Large scale immunization of susceptible human population is highly required to prevent this deadly disease. Attempts should be made as soon as possible to develop effective vaccines or antiviral to prevent ZIKV infection. This article provides a current overview of the experimental therapeutics and treatment options based on modern, complementary and alternative medicines.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1607
[Da] Date of entry for processing:160701
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1007/s13337-016-0307-y

  6 / 13813 MEDLINE  
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[PMID]: 26935235
[Au] Autor:Binkley MS; Hiniker SM; Donaldson SS; Hoppe RT
[Ad] Address:Department of Radiation Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California....
[Ti] Title:Partial orbit irradiation achieves excellent outcomes for primary orbital lymphoma.
[So] Source:Pract Radiat Oncol;6(4):255-61, 2016 Jul-Aug.
[Is] ISSN:1879-8519
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: Primary radiation therapy (RT) achieves excellent local control and overall survival when treating localized orbital lymphoma. However, evidence supporting irradiation of partial orbit volumes to spare nearby critical structures is lacking. We sought to investigate outcomes for patients with localized orbital lymphoma treated with partial orbit irradiation. METHODS AND MATERIALS: We retrospectively reviewed patients with orbital lymphoma treated with RT at our institution who met our inclusion criteria: biopsy-confirmed, low-grade lymphoma, localized disease, partial orbit treatment volumes, and follow-up >3months. The Kaplan-Meier method was used to measure overall survival (OS), and the cumulative incidence function adjusted for the competing risk of death was used to measure local failure (LF), contralateral orbit recurrence (COR), and progression. Patient characteristics were compared with outcomes using Fisher exact test for dichotomous variables and Wilcoxon rank-sum test for continuous variables. RESULTS: Thirty-two patients meeting inclusion criteria were identified with median follow-up of 45.8months (range, 3.6-171.9). The majority had stage IEA disease; their sites included conjunctiva (n=20) and retrobulbar or lacrimal gland (n=12). Median partial orbit RT dose was 30.6Gy (range, 22.5-36). Five-year OS was 100%. Five-year cumulative incidence of LF, COR, and overall disease progression was 5.3%, 5.9%, and 21.4%, respectively. Five-year cumulative incidence of LF was 8.3% for conjunctival disease versus 0.0% for retrobulbar or lacrimal gland involvement (P=.15). No significant association was observed between the outcomes of LF, COR, or progression and pretreatment characteristics. Acute and late toxicity included grade 2 periorbital edema (n=3, 9.4%), dry eye (n=3, 9.4%), retinal vascular disorder (n=1, 3.1%), conjunctivitis (n=2, 6.3%), and grade 3 cataract (n=1, 3.1%). CONCLUSIONS: Use of partial orbit irradiation in treating low-grade, localized orbital lymphoma achieves excellent survival with low rates of LF, COR, or progression.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1607
[Js] Journal subset:IM
[St] Status:In-Data-Review

  7 / 13813 MEDLINE  
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[PMID]: 26956897
[Au] Autor:Ock M; Jo MW; Gong YH; Lee HJ; Lee J; Sim CS
[Ad] Address:Department of Preventive Medicine, University of Ulsan College of Medicine, Seoul, South Korea. ohohoms@naver.com....
[Ti] Title:Estimating the severity distribution of disease in South Korea using EQ-5D-3L: a cross-sectional study.
[So] Source:BMC Public Health;16:234, 2016.
[Is] ISSN:1471-2458
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: There is a paucity of data on the distribution of disease severity. In this study, we estimated disease severity distributions in South Korea using two EQ-5D-3L population surveys. METHODS: A total of 110 health states for 35 diseases with 2-5 severity levels (e.g., mild, moderate, severe) were included in this study. A general population of 360 participants from the areas surrounding Seoul and Gyunggi evaluated these health states using EQ-5D-3L via face-to-face interviews and a paper questionnaire. The EQ-5D indices were used to measure the severity levels of health states and used as the cutoff points for the disease severity distributions. Finally, these cutoff points were applied to disease prevalence data with EQ-5D-3L, which were obtained from the Korean National Health and Nutrition Examination Surveys (KNHNES) and Korean Community Health Survey, in order to estimate the disease severity distributions. RESULTS: The severity distributions of 8 diseases were estimated, including asthma, angina, stroke, chronic obstructive pulmonary disease, major depressive disorder, musculoskeletal problems in the legs, anemia, and allergic rhinitis and conjunctivitis. For example, the EQ-5D indices for chronic obstructive pulmonary disease severity were 0.929, 0.742, and 0.620, and the cut-off points were 0.835 (between mild and moderate) and 0.681 (between moderate and severe). Using these cutoff points, the distributions of chronic obstructive pulmonary disease severity were 66.5 % (mild), 23.3 % (moderate), and 10.1 % (severe) according to KNHNES. CONCLUSIONS: The estimated severity distributions in this study can be used as a valid calculation of the disease burden in the general population.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1603
[Cu] Class update date: 160311
[Lr] Last revision date:160311
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1186/s12889-016-2904-5

  8 / 13813 MEDLINE  
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[PMID]: 26423146
[Au] Autor:Bohlin J
[Ad] Address:Department of Bacteriology and Immunology, Norwegian Institute of Public Health, Lovisenberggata 6, P.O. Box 4404, 0403, Oslo, Norway. jon.bohlin@fhi.no.
[Ti] Title:Genome expansion in bacteria: the curios case of Chlamydia trachomatis.
[So] Source:BMC Res Notes;8:512, 2015.
[Is] ISSN:1756-0500
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Recent findings indicated that a correlation between genomic % AT and genome size within strains of microbial species was predominantly associated with the uptake of foreign DNA. One species however, Chlamydia trachomatis, defied any explanation. In the present study 79 fully sequenced C. trachomatis genomes, representing ocular- (nine strains), urogenital- (36 strains) and lymphogranuloma venereum strains (LGV, 22 strains), in three pathogroups, in addition to 12 laboratory isolates, were scrutinized with the intent of elucidating the positive correlation between genomic AT content and genome size. RESULTS: The average size difference between the strains of each pathogroup was largely explained by the incorporation of genetic fragments. These fragments were slightly more AT rich than their corresponding host genomes, but not enough to justify the difference in AT content between the strains of the smaller genomes lacking the fragments. In addition, a genetic region predominantly found in the ocular strains, which had the largest genomes, was on average more GC rich than the host genomes of the urogenital strains (58.64% AT vs. 58.69% AT), which had the second largest genomes, implying that the foreign genetic regions cannot alone explain the association between genome size and AT content in C. trachomatis. 23,492 SNPs were identified for all 79 genomes, and although the SNPs were on average slightly GC rich (~47% AT), a significant association was found between genome-wide SNP AT content, for each pathogroup, and genome size (p < 0.001, R (2) = 0.86) in the C. trachomatis strains. CONCLUSIONS: The correlation between genome size and AT content, with respect to the C. trachomatis pathogroups, was explained by the incorporation of genetic fragments unique to the ocular and/or urogenital strains into the LGV- and urogential strains in addition to the genome-wide SNP AT content differences between the three pathogroups.
[Mh] MeSH terms primary: Chlamydia trachomatis/genetics
Genome Size
Genome, Bacterial
Phylogeny
Polymorphism, Single Nucleotide
[Mh] MeSH terms secundary: Bacterial Outer Membrane Proteins/genetics
Base Composition
Chlamydia trachomatis/classification
Chlamydia trachomatis/isolation & purification
Conjunctivitis, Inclusion/microbiology
Conjunctivitis, Inclusion/pathology
DNA Transposable Elements
Genotype
Humans
Lymphogranuloma Venereum/microbiology
Lymphogranuloma Venereum/pathology
Trachoma/microbiology
Trachoma/pathology
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Bacterial Outer Membrane Proteins); 0 (DNA Transposable Elements); 149024-69-1 (OMPA outer membrane proteins)
[Em] Entry month:1607
[Cu] Class update date: 151004
[Lr] Last revision date:151004
[Js] Journal subset:IM
[Da] Date of entry for processing:151001
[St] Status:MEDLINE
[do] DOI:10.1186/s13104-015-1464-6

  9 / 13813 MEDLINE  
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[PMID]: 26927330
[Au] Autor:Ayaki M; Kawashima M; Negishi K; Kishimoto T; Mimura M; Tsubota K
[Ad] Address:Department of Ophthalmology Keio University, School of Medicine, Tokyo, Japan....
[Ti] Title:Sleep and mood disorders in dry eye disease and allied irritating ocular diseases.
[So] Source:Sci Rep;6:22480, 2016.
[Is] ISSN:2045-2322
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The aim of the present study was to evaluate sleep and mood disorders in patients with irritating ocular diseases. The study design was a cross-sectional/case-control study conducted in six eye clinics. Out of 715 outpatients diagnosed with irritating ocular surface diseases and initially enrolled, 301 patients with dry eye disease (DED) and 202 age-matched control participants with other ocular surface diseases were analyzed. The mean Pittsburgh Sleep Quality Index (PSQI) and Hospital Anxiety and Depression Scale (HADS) scores were 6.4 ± 3.2 and 11.1 ± 5.7 for severe DED (n = 146), 5.5 ± 3.3 and 9.8 ± 4.0 for mild DED (n = 155), 5.5 ± 3.1 and 9.5 ± 6.6 for chronic conjunctivitis (n = 124), and 5.0 ± 3.3 and 8.9 ± 5.3 for allergic conjunctivitis (n = 78). There were significant differences among these diagnostic groups for PSQI (P < 0.05). Regression analysis of patients with DED revealed the PSQI and HADS scores were significantly correlated with the severity of DED (P < 0.05). Our results demonstrate that sleep quality in patients with DED is significantly worse than in patients with other irritating ocular surface diseases and it is correlated with the severity of DED.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1603
[Cu] Class update date: 160308
[Lr] Last revision date:160308
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1038/srep22480

  10 / 13813 MEDLINE  
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[PMID]: 27352492
[Au] Autor:Ni W; Li J; Ji Q; Song Y; Liu B; Wang G; Zhu J; Chen H
[Ti] Title:[Clinical efficacy on xerosis conjunctivitis of liver and kidney yin deficiency treated with SHI's acupuncture manipulation].
[So] Source:Zhongguo Zhen Jiu;36(4):364-8, 2016 Apr.
[Is] ISSN:0255-2930
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To compare the efficacy of the patients of xerosis conjunctivitis with liver and kidney yin deficiency among the combined therapy of acupuncture and Shi's manipulation, common acupuncture and artificial tears therapy. METHODS: One hundred and eight patients were randomized into an acupuncture group, a SHI's manipulation group and an artificial tears group, 36 cases in each group. A total of 15 cases dropped out before the end of the study, including 4 cases in the acupuncture group, 6 cases in the SHI's manipulation group, and 5 cases in the artificial tears group. In the acupuncture group, acupuncture was applied to Jingming (BL 1) and Qiuhou (EX-HN 7) on the affected side, and the bilateral Sanyinjiao (SP 6) and Taixi (KI 3). The needles were retained for 20 min. In the SHI's manipulation group, on the basis of the treatment as the acupuncture group, Shuigou (GV26) was added and stimulated with SHI's acupuncture manipulation. In these two groups, acupuncture was given 3 times a week totally for 3 weeks. In the artificial tears group, sodium hyaluronate eye drops were used, 5 times a day, for 3 weeks totally. Separately, before treatment, at the moment after the 1st treatment and 3 weeks after treatment, the subjective symptom score, Schirmer I test, breakup time (BUT) of tear film were observed in each group. RESULTS: (1) Subjective symptom score: at the moment after the 1st treatment and 3 weeks after treatment, the scores in each group were all reduced significantly as compared with those before treatment (all P < 0.05). At the moment after the 1st treatment, the score in the SHI's manipulation group and the artificial tears group was reduced apparently as compared with that in the acupuncture group (both P < 0.05). In 3 weeks of treatment, the score in the SHI's manipulation group was reduced apparently as compared with the acupuncture group and the artificial tears group (both P < 0.05). (2) For Schirmer I test, at the moment of the 1st treatment, the result in the SHI's manipulation group and the artificial tears group was improved significantly as compared with that before treatment (both P < 0.05). In 3 weeks of treatment, the result in the acupuncture group and the SHI's manipulation group group was improved significantly as compared with that before treatment (both P < 0.05). At the moment of the 1st treatment, the result in the artificial tears group was improved significantly as compared with the acupuncture group and the SHI's manipulation group (both P < 0.05). In 3 weeks of treatment, the result in the acupuncture group and the SHI's manipulation group was better than that in the artifi-cial tears group separately (both P < 0.05). (3) For BUT, the result in the acupuncture group and the SHI's manipulation group was prolonged significantly as compared with that before treatment and was prolonged apparently as compared with that in the artificial tears group (both P < 0.05) in 3 weeks of treatment. CONCLUSION: The intervention of SHI's acupuncture manipulation relieves the subjective symptoms of xerosis conjunctivitis of liver and kidney yin deficiency and achieves the same efficacy as the common acupuncture and artificial tears treatment. It does not present the apparent advantages as the common acupuncture in the short term for promoting the tear secretion and tears film repair.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[St] Status:In-Process


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