Database : MEDLINE
Search on : Conjunctivitis [Words]
References found : 13065 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 1307 go to page                         

  1 / 13065 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 25590460
[Au] Autor:Fehily SR; Cross GB; Fuller AJ
[Ad] Address:Infectious Disease Unit, Alfred Hospital, Melbourne, Australia.
[Ti] Title:Bilateral conjunctivitis in a returned traveller.
[So] Source:PLoS Negl Trop Dis;9(1):e0003351, 2015 Jan.
[Is] ISSN:1935-2735
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1371/journal.pntd.0003351

  2 / 13065 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 25571794
[Au] Autor:Grosche P; Sirockin F; Mac Sweeney A; Ramage P; Erbel P; Melkko S; Bernardi A; Hughes N; Ellis D; Combrink KD; Jarousse N; Altmann E
[Ad] Address:Novartis Institute for Biomedical Research, Novartis Campus, CH-4002 Basel, Switzerland....
[Ti] Title:Structure-based design and optimization of potent inhibitors of the adenoviral protease.
[So] Source:Bioorg Med Chem Lett;25(3):438-43, 2015 Feb 1.
[Is] ISSN:1464-3405
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Adenoviral infections are associated with a wide range of acute diseases, among which ocular viral conjunctivitis (EKC) and disseminated disease in immunocompromised patients. To date, no approved specific anti-adenoviral drug is available, but there is a growing need for an effective treatment of such infections. The adenoviral protease, adenain, plays a crucial role for the viral lifecycle and thus represents an attractive therapeutic target. Structure-guided design with the objective to depeptidize tetrapeptide nitrile 1 led to the novel chemotype 2. Optimization of scaffold 2 resulted in picomolar adenain inhibitors 3a and 3b. In addition, a complementary series of irreversible vinyl sulfone containing inhibitors were rationally designed, prepared and evaluated against adenoviral protease. High resolution X-ray co-crystal structures of representatives of each series proves the successful design of these inhibitors and provides an excellent basis for future medicinal chemistry optimization of these compounds.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Js] Journal subset:IM
[St] Status:In-Data-Review

  3 / 13065 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 25590314
[Au] Autor:Chang DY; Joo YH; Kim SJ; Kim JH; Jung MH; Kim DW; Jeon SY; Kim SW
[Ad] Address:Department of Otorhinolaryngology, Gyeongsang National University Hospital, Jinju, Republic of Korea.
[Ti] Title:Therapeutic effects of intranasal cyclosporine for eosinophilic rhinosinusitis with nasal polyps in a mouse model.
[So] Source:Am J Rhinol Allergy;29(1):29-32, 2015 Jan.
[Is] ISSN:1945-8932
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is a principally type 2 T helper cell (Th2)-mediated inflammatory disease. Systemic corticosteroids currently represent the most effective treatment for CRSwNP, but their long-term use is constrained due to their detrimental side effects. Long-term use of topical steroids is safe, but their efficacy is often limited. Topical cyclosporine has proven to be safe and effective for Th2-mediated diseases such as allergic conjunctivitis. OBJECTIVE: It was hypothesized that topical cyclosporine would be an effective novel drug for the treatment of CRSwNP; its therapeutic efficacy was assessed using a previously established mouse model. METHODS: After induction of eosinophilic CRSwNP in four-week-old BALB/c mice according to previous protocols, the therapeutic effects of intranasal cyclosporine were evaluated and compared with those of triamcinolone acetonide (TAC). Histopathologic changes were evaluated using hematoxylin and eosin for polyp formation and Sirius red staining for eosinophilic infiltration. The production of cytokines in sinonasal tissues, including tumor necrosis factor (TNF), interleukin (IL)-2, interferon (IFN)-γ, IL-4, IL-5, IL-13, and IL-17A, was measured using a cytometric bead array. RESULTS: The number of polyp-like lesions was reduced significantly only by systemic TAC, but the degree of eosinophilic infiltration was decreased significantly by topical cyclosporine, the potency of which was similar to that of topical or systemic TAC. Except for IFN-γ, the majority of measured cytokines were reduced significantly by topical cyclosporine, although their effects on IL-2 and IL-13 were less potent than those of systemic TAC. CONCLUSION: Topical cyclosporine might be an effective drug for the management of CRSwNP.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.2500/ajra.2015.29.4152

  4 / 13065 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 25223647
[Au] Autor:Jelocnik M; Walker E; Pannekoek Y; Ellem J; Timms P; Polkinghorne A
[Ad] Address:Institute for Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia; Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Sippy Downs, Queensland , 4556 Australia....
[Ti] Title:Evaluation of the relationship between Chlamydia pecorum sequence types and disease using a species-specific multi-locus sequence typing scheme (MLST).
[So] Source:Vet Microbiol;174(1-2):214-22, 2014 Nov 7.
[Is] ISSN:1873-2542
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Chlamydia pecorum is globally associated with several ovine diseases including keratoconjunctivitis and polyarthritis. The exact relationship between the variety of C. pecorum strains reported and the diseases described in sheep remains unclear, challenging efforts to accurately diagnose and manage infected flocks. In the present study, we applied C. pecorum multi-locus sequence typing (MLST) to C. pecorum positive samples collected from sympatric flocks of Australian sheep presenting with conjunctivitis, conjunctivitis with polyarthritis, or polyarthritis only and with no clinical disease (NCD) in order to elucidate the exact relationships between the infecting strains and the range of diseases. Using Bayesian phylogenetic and cluster analyses on 62 C. pecorum positive ocular, vaginal and rectal swab samples from sheep presenting with a range of diseases and in a comparison to C. pecorum sequence types (STs) from other hosts, one ST (ST 23) was recognised as a globally distributed strain associated with ovine and bovine diseases such as polyarthritis and encephalomyelitis. A second ST (ST 69) presently only described in Australian animals, was detected in association with ovine as well as koala chlamydial infections. The majority of vaginal and rectal C. pecorum STs from animals with NCD and/or anatomical sites with no clinical signs of disease in diseased animals, clustered together in a separate group, by both analyses. Furthermore, 8/13 detected STs were novel. This study provides a platform for strain selection for further research into the pathogenic potential of C. pecorum in animals and highlights targets for potential strain-specific diagnostic test development.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Process

  5 / 13065 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 24594452
[Au] Autor:Morozumi M; Shimizu H; Matsushima Y; Mitamura K; Tajima T; Iwata S; Ubukata K
[Ad] Address:Laboratory of Molecular Epidemiology for Infectious Agents, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan; Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan....
[Ti] Title:Evaluation of new immunochromatographic assay kit for adenovirus detection in throat swab: comparison with culture and real-time PCR results.
[So] Source:J Infect Chemother;20(5):303-6, 2014 May.
[Is] ISSN:1437-7780
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:A new immunochromatographic (IC) assay kit, BD Veritor System Adeno was evaluated to comparing with commercial available kit, BD Adeno Examan, cell culture, and real-time PCR using throat swab samples. Specimens were collected from 146 pediatric patients between July 2011 and January 2012. Mean age of patients was 4 years (8 months-15 years old). Patients were diagnosed with pharyngitis (n = 67), tonsillitis (n = 45), pharyngoconjunctival fever (n = 26), upper respiratory tract infection (n = 6), conjunctivitis (n = 1), or bronchitis (n = 1). Thirty-one of the patients (21.2%) had more than one disease. Among all samples, 61 (41.8%) were positive for adenovirus with BD Veritor System Adeno; 68 (46.6%) with BD Adeno Examan; 63 (43.2%) with real-time PCR; and 65 (44.5%) with cell culture. Serotype 3 (n = 41; 63.1%) was predominant among the 65 adenovirus isolates, followed by serotype 2 (n = 12; 18.5%), 1 (n = 6; 9.2%), 5 (n = 4; 6.2%), and 4 (n = 2; 3.1%). Relative sensitivity and specificity of BD Veritor System Adeno, BD Adeno Examan, and real-time PCR were 93.8% and 98.7%, 96.9% and 93.8%, and 96.9% and 100%, respectively. Positive predictive and negative predictive values for these methods were 98.4% and 95.1%, 92.6% and 97.4%, and 100% and 97.6%, respectively. The sensitivity and specificity of real-time PCR was greater than that of IC assay kits. However, IC assay kits also showed high sensitivity and specificity appropriate for clinical use.
[Mh] MeSH terms primary: Adenoviruses, Human/isolation & purification
Immunochromatography/methods
Pharynx/virology
Reagent Kits, Diagnostic
Real-Time Polymerase Chain Reaction/methods
[Mh] MeSH terms secundary: Humans
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Name of substance:0 (Reagent Kits, Diagnostic)
[Em] Entry month:1501
[Js] Journal subset:IM
[Da] Date of entry for processing:140422
[St] Status:MEDLINE

  6 / 13065 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 23385072
[Au] Autor:Herzog A; Buchholz J; Ruess-Melzer K; Lang J; Kaser-Hotz B
[Ad] Address:Animal Oncology and Imaging Center, Hünenberg. herzog@aoicenter.ch
[Ti] Title:Kombinierte Anwendung von Strahlentherapie und DNS Tumor Vakzine zur Behandlung des oralen malignen Melanoms beim Hund: Eine Pilotstudie. [Combined use of irradiation and DNA tumor vaccine to treat canine oral malignant melanoma: a pilot study].
[So] Source:Schweiz Arch Tierheilkd;155(2):135-42, 2013 Feb.
[Is] ISSN:0036-7281
[Cp] Country of publication:Switzerland
[La] Language:ger
[Ab] Abstract:Melanoma is the most common oral tumor in dogs, characterized by rapid growth, local invasion, and high metastatic rate. The goal of this study was to evaluate the combination of radiation therapy and DNA tumor vaccine. We hypothesized, that the concurrent use would not increase toxicity. Nine dogs with oral melanoma were treated with 4 fractions of 8 Gray at 7-day intervals. The vaccine was given 4 times every 14 days, beginning at the first radiation fraction. Local acute radiation toxicities were assessed according to the VRTOG toxicity scoring scheme over a time period of 7 weeks. In none of the evaluated dogs, mucositis, dermatitis and conjunctivitis exceeded grade 2. In 3 dogs mild fever, lethargy, and local swelling at the injection site were seen after vaccine application. In conclusion, the concurrent administration of radiation therapy and vaccine was well tolerated in all dogs.
[Mh] MeSH terms primary: Cancer Vaccines/therapeutic use
Dog Diseases/therapy
Melanoma/veterinary
Mouth Neoplasms/veterinary
Vaccines, DNA/therapeutic use
[Mh] MeSH terms secundary: Animals
Combined Modality Therapy/veterinary
Dog Diseases/radiotherapy
Dogs
Female
Male
Melanoma/radiotherapy
Melanoma/therapy
Mouth Neoplasms/radiotherapy
Mouth Neoplasms/therapy
Pilot Projects
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Name of substance:0 (Cancer Vaccines); 0 (Vaccines, DNA)
[Em] Entry month:1501
[Js] Journal subset:IM
[Da] Date of entry for processing:130206
[St] Status:MEDLINE
[do] DOI:10.1024/0036-7281/a000430

  7 / 13065 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text
Full text

[PMID]: 25565052
[Au] Autor:Gemicioglu B; Musellim B; Dogan I; Guven K
[Ad] Address:Department of Pulmonary Diseases, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
[Ti] Title:Fractional exhaled nitric oxide (FeNo) in different asthma phenotypes.
[So] Source:Allergy Rhinol (Providence);5(3):157-61, 2014 Jan.
[Is] ISSN:2152-6575
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Fractioned exhaled nitric oxide (FeNO) is a noninvasive marker of inflammation in asthmatic patients. FeNO can be used to monitor airway inflammation, but individual responses make tailored interventions based on FeNO difficult. The correlation between the asthma control test (ACT), FEV1, and FeNO was evaluated in this study to ascertain the correct usage of FeNO with different asthma phenotypes regarding their control, allergy, comorbidity, obesity, age, smoking status, and severity. ACT, pulmonary function, and FeNO in 416 asthmatic patients on combined therapy were retrospective evaluated. Correlations between these parameters and the FeNO levels in different asthma phenotypes were calculated. In the study population, FeNO was 31.8 ± 28.5 parts per billion (ppb), FEV1 was 83.4 ± 19% and ACT was 19 ± 5.2. ACT scores were negatively correlated with FeNO (r = -0.31; p = 0.002). FeNO was different in patients with positive and negative skin-prick test (p < 0.05), with and without allergic rhinitis (p < 0.01), and with and without allergic conjunctivitis (p < 0.01). Significantly higher FeNO levels were found with logistic regression analysis only in patients with a history of emergency room visits (ERVs) (p = 0.024). The rate of the ERV of the patients with an ACT score more than or equal to 20 and with a FeNO value of more than 35 ppb was 22.9%, but with a FeNO value of less than 35 ppb was 6.5% (p = 0.004). Allergy and allergic comorbidities may lead to an increase in FeNO levels. Patients with a history of ERV have markedly higher FeNO levels, although they have an ACT score more than or equal to 20.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150113
[Lr] Last revision date:150113
[Da] Date of entry for processing:150108
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.2500/ar.2014.5.0099

  8 / 13065 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text
Full text

[PMID]: 25553262
[Au] Autor:Cibella F; Ferrante G; Cuttitta G; Bucchieri S; Melis MR; La Grutta S; Viegi G
[Ad] Address:National Research Council of Italy, Institute of Biomedicine and Molecular Immunology, Palermo, Italy....
[Ti] Title:The burden of rhinitis and rhinoconjunctivitis in adolescents.
[So] Source:Allergy Asthma Immunol Res;7(1):44-50, 2015 Jan.
[Is] ISSN:2092-7355
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:PURPOSE: Rhinitis and conjunctivitis are common diseases worldwide that are frequently associated. Nevertheless, the risk factors for rhinoconjunctivitis are not well-described and the impact of conjunctivitis on rhinitis and asthma in children remains unknown. This study explored the different risk factors and evaluated the burden of rhinoconjunctivitis among adolescents. METHODS: This was a cross-sectional study conducted on a random sample of schoolchildren, aged 10-17 years, using skin prick tests and a self-administered questionnaire on respiratory health investigating the impact of rhinitis and rhinoconjunctivitis on daily activities. RESULTS: A complete evaluation was obtained for 2,150 children. The prevalence of rhinitis alone was 18.2% and rhinitis associated with conjunctivitis was 20.5%. Rhinoconjunctivitis was more frequently associated with females, a parental history of atopy, domestic exposure to mold/dampness, passive smoke exposure, and reported truck traffic in residential streets. Moreover, rhinoconjunctivitis was associated with a higher level of allergic sensitization. The prevalence of current asthma was 1.7% in subjects without rhinitis or rhinoconjunctivitis, 5.1% in rhinitis and 10.7% in rhinoconjunctivitis. In a logistic model, rhinoconjunctivitis yielded a 2-fold risk for current asthma with respect to rhinitis. Subjects with rhinoconjunctivitis had poorer quality of life (QoL); there was an impact on daily activities in 4.6% of rhinitis and 10.7% of rhinoconjunctivitis. CONCLUSIONS: Ocular symptoms increase the role of rhinitis as a risk factor for asthma and its impact on daily activities in children.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150113
[Lr] Last revision date:150113
[Da] Date of entry for processing:150101
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4168/aair.2015.7.1.44

  9 / 13065 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text
Full text

[PMID]: 25471667
[Au] Autor:Kolawole OM; Oladosu TO; Abdulkarim AA; Okoh AI
[Ad] Address:Department of Biochemistry and Microbiology, Applied and Environmental Microbiology Research Group, University of Fort Hare, Alice, South Africa. tomak74@yahoo.com.
[Ti] Title:Prevalence of adenovirus respiratory tract and hiv co-infections in patients attending the University of Ilorin, teaching hospital, Ilorin, Nigeria.
[So] Source:BMC Res Notes;7:870, 2014.
[Is] ISSN:1756-0500
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Adenovirus co-infections in HIV patients cause wide-spread morbidity in sub-Saharan Africa, but little research has documented the burden and distribution of these pathogens. This study was conducted between December, 2010 and March, 2011 to investigate the prevalence of Adenovirus Respiratory Tract and HIV co-infections in Patients attending the University of Ilorin Teaching Hospital Ilorin, Nigeria. METHOD: One Hundred and Eighty Four (184) patients were recruited with confirmed HIV positive status. Investigation was done by serology using the Human Adenovirus IgG ELISA Kit to test for the presence of the Immunoglobulin G (antibody) against the virus. This was conducted and juxtaposed simultaneously with responses received from the questionnaires provided to each participant to correlate the relationship of the co-infections to their socio-demographic factors (Age, Gender, Occupation and location of residence), risk factors (Average hours of exposure per day (time spent outdoor daily), proximity of their apartments to livestock settlements), recent occurrence of respiratory tract infections/conjunctivitis and their ART status. RESULTS: This study recorded a prevalent rate of 38% (70 patients) to the co-infections. Nevertheless, 62% (114 patients) tested negative to the co-infections. CONCLUSION: There was statistical significance between the ages of HIV patients and Adenovirus co-infection (p < 0.05). However, there was no significance with respect to gender of the subjects (p > 0.05). The findings also showed that there were statistical significance for all the risk factors; Occupation, Location and Proximity to Livestock settlement, recent respiratory tract infection/conjunctivitis, and ART status in relation to Adenovirus and HIV co-infections (p < 0.05).
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Cu] Class update date: 150113
[Lr] Last revision date:150113
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1186/1756-0500-7-870

  10 / 13065 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 22921805
[Au] Autor:Chen YJ; Yu HH; Yang YH; Lau YL; Lee WI; Chiang BL
[Ad] Address:Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan....
[Ti] Title:Recurrent abdominal pain as the presentation of tumor necrosis factor receptor-associated periodic syndrome (TRAPS) in an Asian girl: a case report and review of the literature.
[So] Source:J Microbiol Immunol Infect;47(6):550-4, 2014 Dec.
[Is] ISSN:1995-9133
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is characterized by periodic fever, cutaneous rash, conjunctivitis, lymphadenopathy, abdominal pain, myalgia, and arthralgia. It is a rare autosomal dominant disease and strongly associated with heterozygous mutations in the tumor necrosis factor (TNF) receptor super family 1A (TNFRSF1A) gene. It is believed to be more common in Western countries than in Asian countries. Here, we present the case of a 14-year-old girl with periodic fever and abdominal pain with elevation of inflammatory markers for 2 years. After extensive work-up of infectious etiology with negative results, the diagnosis of TRAPS was made although no gene mutations were identified in the TNFRSF1A gene, MVK gene, and NALP3/CIAS1 gene. She had partial clinical response to corticosteroids and immunomodulatory agents. However, the treatment response to TNF-α inhibitor etanercept was dramatic. She has remained symptom free under regular weekly to biweekly etanercept treatment for 2 years. We also reviewed the related literature and summarized the data of 10 Asian cases of TRAPS.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Process


page 1 of 1307 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information