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Search on : Conjunctivitis [Words]
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[PMID]: 26275056
[Au] Autor:Flores-Páez LA; Zenteno JC; Alcántar-Curiel MD; Vargas-Mendoza CF; Rodríguez-Martínez S; Cancino-Diaz ME; Jan-Roblero J; Cancino-Diaz JC
[Ad] Address:Department of Microbiology, Escuela Nacional de Ciencias Biológicas-Instituto Politécnico Nacional, Mexico City, Mexico....
[Ti] Title:Molecular and Phenotypic Characterization of Staphylococcus epidermidis Isolates from Healthy Conjunctiva and a Comparative Analysis with Isolates from Ocular Infection.
[So] Source:PLoS One;10(8):e0135964, 2015.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Staphylococcus epidermidis is a common commensal of healthy conjunctiva and it can cause endophthalmitis, however its presence in conjunctivitis, keratitis and blepharitis is unknown. Molecular genotyping of S. epidermidis from healthy conjunctiva could provide information about the origin of the strains that infect the eye. In this paper two collections of S. epidermidis were used: one from ocular infection (n = 62), and another from healthy conjunctiva (n = 45). All isolates were genotyped by pulsed field gel electrophoresis (PFGE), multilocus sequence typing (MLST), staphylococcal cassette chromosome mec (SCCmec), detection of the genes icaA, icaD, IS256 and polymorphism type of agr locus. The phenotypic data included biofilm production and antibiotic resistance. The results displayed 61 PFGE types from 107 isolates and they were highly discriminatory. MLST analysis generated a total of 25 STs, of which 11 STs were distributed among the ocular infection isolates and lineage ST2 was the most frequent (48.4%), while 14 STs were present in the healthy conjunctiva isolates and lineage ST5 was the most abundant (24.4%). By means of a principal coordinates analysis (PCoA) and a discriminant analysis (DA) it was found that ocular infection isolates had as discriminant markers agr III or agr II, SCCmec V or SCCmec I, mecA gene, resistance to tobramycin, positive biofilm, and IS256+. In contrast to the healthy conjunctiva isolates, the discriminating markers were agr I, and resistance to chloramphenicol, ciprofloxacin, gatifloxacin and oxacillin. The discriminant biomarkers of ocular infection were examined in healthy conjunctiva isolates, and it was found that 3 healthy conjunctiva isolates [two with ST2 and another with ST9] (3/45, 6.66%) had similar genotypic and phenotypic characteristics to ocular infection isolates, therefore a small population from healthy conjunctiva could cause an ocular infection. These data suggest that the healthy conjunctiva isolates do not, in almost all cases, infect the eye due to their large genotypic and phenotypic difference with the ocular infection isolates.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1508
[Cu] Class update date: 150821
[Lr] Last revision date:150821
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1371/journal.pone.0135964

  2 / 13319 MEDLINE  
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[PMID]: 26293786
[Au] Autor:Rocha-Cabrera P; Reyes-Batlle M; Martín-Navarro CM; Dorta-Gorrín A; López-Arencibia A; Sifaoui I; Martínez-Carretero E; Piñero JE; Martín-Barrera F; Valladares B; Lorenzo-Morales J
[Ad] Address:1​University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda Astrofísico Fco. Sánchez, S/N, 38203 La Laguna, Tenerife, Canary Islands, Spain 2​Department of Ophthalmology, Hospital Universitario de Canarias, Tenerife, Canary Islands, Spain....
[Ti] Title:Detection of Acanthamoeba on the ocular surface in a Spanish population using the Schirmer strip test: pathogenic potential, molecular classification and evaluation of the sensitivity to chlorhexidine and voriconazole of the isolated Acanthamoeba strains.
[So] Source:J Med Microbiol;64(8):849-53, 2015 Aug.
[Is] ISSN:1473-5644
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Pathogenic strains of Acanthamoeba are causative agents of a sight-threatening infection of the cornea known as Acanthamoeba keratitis, which is often associated with the misuse of contact lenses. However, there is still a question remaining to be answered, which is whether these micro-organisms are present on the ocular surface of healthy individuals. Therefore, the aim of this study was to determine the presence of Acanthamoeba on the ocular surface in healthy patients and also in those with other ocular surface infections. Sterile Schirmer test strips were used to collect samples from a group of patients who attended an ophthalmology consultation at the Hospital del Norte, Icod de los Vinos, Tenerife, Canary Islands. Most of the patients (46 individuals, 79.31  %) presented ocular surface pathologies such as blepharitis or conjunctivitis; the rest did not present any pathology. None of the patients included in the study wore contact lenses. The collected samples were cultured in 2  % non-nutrient agar plates and positive plates were then cultured in axenic conditions for further analyses. Molecular analysis classified all isolated strains as belonging to Acanthamoeba genotype tbl4, and osmotolerance and thermotolerance assays revealed that all strains were potentially pathogenic. Furthermore, all strains were assayed for sensitivity against voriconazole and chlorhexidine. Assays showed that both drugs were active against the tested strains. In conclusion, the Schirmer strip test is proposed as an effective tool for the detection of Acanthamoeba on the ocular surface.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1508
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1099/jmm.0.000103

  3 / 13319 MEDLINE  
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[PMID]: 26056901
[Au] Autor:Goodnight AL
[Ti] Title:DIAGNOSIS AND PALLIATIVE MANAGEMENT OF ATOPIC DERMATITIS IN A MALAYAN FLYING FOX (PTEROPUS VAMPYRUS).
[So] Source:J Zoo Wildl Med;46(2):386-92, 2015 Jun.
[Is] ISSN:1042-7260
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:A 7-yr-old male Malayan flying fox (Pteropus vampyrus) presented with chronic, recurrent bilateral conjunctivitis and palpebral chemosis. Variable, temporary response to topical ocular antibiotic-corticosteroid therapy occurred. Histopathology of a conjunctival biopsy was consistent with allergic conjunctivitis. The bat was treated systemically with antihistamines and topically with an ocular antibiotic-corticosteroid combination for acute episodes of conjunctivitis. Pruritus, severe alopecia of the head and neck, and moist dermatitis later developed in conjunction with bilateral conjunctivitis. Cytology and histopathology of affected skin supported a diagnosis of atopic dermatitis. Although the assay was not validated for P. vampyrus, serum immunoglobulin E levels against multiple possible antigens were measured. Acceptable resolution of clinical signs was achieved for 20 mo following systemic cyclosporine administration. Cyclosporine levels were measured in whole blood for additional therapeutic monitoring. This is the first reported case of histopathologic support for atopic dermatitis, novel diagnostics, and palliative management of atopy using cyclosporine in a flying fox.
[Mh] MeSH terms primary: Chiroptera
Cyclosporine/therapeutic use
Dermatitis, Atopic/veterinary
Glucocorticoids/therapeutic use
Immunosuppressive Agents/therapeutic use
Triamcinolone/therapeutic use
[Mh] MeSH terms secundary: Animals
Dermatitis, Atopic/diagnosis
Dermatitis, Atopic/drug therapy
Male
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Glucocorticoids); 0 (Immunosuppressive Agents); 1ZK20VI6TY (Triamcinolone); 83HN0GTJ6D (Cyclosporine)
[Em] Entry month:1508
[Js] Journal subset:IM
[Da] Date of entry for processing:150610
[St] Status:MEDLINE
[do] DOI:10.1638/2014-0141R.1

  4 / 13319 MEDLINE  
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[PMID]: 25724936
[Au] Autor:De Boeck C; Kalmar I; Dumont A; Vanrompay D
[Ad] Address:Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium Cindy.Deboeck@ugent.be....
[Ti] Title:Longitudinal monitoring for respiratory pathogens in broiler chickens reveals co-infection of Chlamydia psittaci and Ornithobacterium rhinotracheale.
[So] Source:J Med Microbiol;64(Pt 5):565-74, 2015 May.
[Is] ISSN:1473-5644
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Chlamydia psittaci is prevalent in broiler chicken production. However, the role of C. psittaci in the respiratory disease complex needs to be clarified. Our aim was to identify the time point when a C. psittaci infection appeared on a broiler farm and to examine the presence of other respiratory pathogens at that time. We focused on the 'major' respiratory pathogens occurring in Belgian broilers, namely infectious bronchitis virus (IBV), avian metapneumovirus (aMPV), Ornithobacterium rhinotracheale, Mycoplasma gallisepticum and Mycoplasma synoviae, and examined their co-occurrence with C. psittaci on three commercial broiler farms. For all farms, 1-day-old broilers showed high maternal antibody titres against C. psittaci in the presence of viable C. psittaci. Maternal antibodies seemed to protect against respiratory signs. Maternal antibodies declined and clinical outbreaks could be identified serologically even before maternal antibodies completely disappeared. Mixed infections with genotypes B/C and B/C/D were observed. Broilers with C. psittaci antibody increases showed conjunctivitis, signs of upper respiratory disease and dyspnoea. C. psittaci always preceded an O. rhinotracheale infection. Infections with aMPV, IBV or Mycoplasma spp. were not observed. Evidence was provided that C. psittaci could occur at an early age in broilers without a predisposing respiratory infection. Both C. psittaci and O. rhinotracheale should be considered when developing prevention strategies for respiratory disease in broilers.
[Mh] MeSH terms primary: Chlamydophila psittaci/isolation & purification
Coinfection/veterinary
Flavobacteriaceae Infections/veterinary
Ornithobacterium/isolation & purification
Poultry Diseases/microbiology
Psittacosis/veterinary
[Mh] MeSH terms secundary: Animals
Belgium/epidemiology
Chickens
Coinfection/epidemiology
Coinfection/microbiology
Flavobacteriaceae Infections/epidemiology
Flavobacteriaceae Infections/microbiology
Psittacosis/epidemiology
Psittacosis/microbiology
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1508
[Js] Journal subset:IM
[Da] Date of entry for processing:150609
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000047

  5 / 13319 MEDLINE  
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[PMID]: 25454510
[Au] Autor:Pajno GB; Nadeau KC; Passalacqua G; Caminiti L; Hobson B; Jay DC; Arasi S; Chiera F; Salzano G
[Ad] Address:Department of Pediatrics- Allergy Unit, University of Messina, Via Consolare Valeria-Gazzi, 98124 Messina, Italy.
[Ti] Title:The evolution of allergen and non-specific immunotherapy: past achievements, current applications and future outlook.
[So] Source:Expert Rev Clin Immunol;11(1):141-54, 2015 Jan.
[Is] ISSN:1744-8409
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Recent epidemiological studies estimated that more than 30% of European suffer from allergic rhinitis or conjunctivitis, while up to 20% suffer from asthma and 15% from allergic skin conditions, while for many other regions the prevalence is increasing. Allergen immunotherapy represents the only available treatment that can modify the allergic disease process, and thus is worth considering as a treatment in affected individuals. A beneficial effect of allergen immunotherapy has been shown in both adults and children affected by allergic rhinitis, allergic conjunctivitis, allergic asthma and hymenoptera venom allergy. The present study represents an overview on allergen immunotherapy, focusing on the principal aspects of the use of immunotherapy in the past, its recent clinical applications and future outlook.
[Mh] MeSH terms primary: Allergens/therapeutic use
Desensitization, Immunologic/methods
Hypersensitivity/therapy
[Mh] MeSH terms secundary: Adolescent
Adult
Child
Child, Preschool
Desensitization, Immunologic/trends
Female
Humans
Hypersensitivity/epidemiology
Male
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Allergens)
[Em] Entry month:1508
[Js] Journal subset:IM
[Da] Date of entry for processing:141223
[St] Status:MEDLINE
[do] DOI:10.1586/1744666X.2015.977260

  6 / 13319 MEDLINE  
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[PMID]: 25900842
[Au] Autor:Puri S; Bhattarai D; Adhikari P; Shrestha JB; Paudel N
[Ad] Address:B P Koirala Lions Centre for Ophthalmic Studies, Institute of Medicine, Kathmandu, Nepal....
[Ti] Title:Burden of ocular and visual disorders among pupils in special schools in Nepal.
[So] Source:Arch Dis Child;100(9):834-7, 2015 Sep.
[Is] ISSN:1468-2044
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVES: To determine detailed oculo-visual characteristics of children with intellectual disability studying in special schools and explore the burden of visual impairment. DESIGN OF THE STUDY: Detailed ophthalmic examination was carried out in all pupils studying at the seven special needs schools of Kathmandu valley, Nepal. Ophthalmic examination included case history, presenting distance visual acuity, cycloplegic refraction, binocular vision examination, contrast sensitivity and anterior and posterior segment evaluation. MAIN OUTCOME MEASURES: Ocular and visual status of children. RESULTS: Refractive errors (40%) and strabismus (17%) were the commonest visual disorders in our study children. Ninety-five per cent of the children who had clinically significant refractive errors presented without any correction. Visual impairment was present in 25% of the children. Severe visual impairment or worse was present in 3% of the children. Other common ocular findings were conjunctivitis, blepharitis, chalazion and ectropion. CONCLUSIONS: High prevalence of preventable visual impairment in this population requires immediate attention. It is hoped that the formulation of proper vision care guidelines at a national level may help in early detection and management of visual disorders in this special population and enhance their quality of life.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1508
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.1136/archdischild-2014-308131

  7 / 13319 MEDLINE  
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[PMID]: 26061233
[Au] Autor:Zanluca C; de Melo VC; Mosimann AL; Dos Santos GI; Dos Santos CN; Luz K
[Ad] Address:Laboratório de Virologia Molecular, Instituto Carlos Chagas, Fundação Oswaldo Cruz, Curitiba, PR, Brasil....
[Ti] Title:First report of autochthonous transmission of Zika virus in Brazil.
[So] Source:Mem Inst Oswaldo Cruz;110(4):569-72, 2015 Jun.
[Is] ISSN:1678-8060
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:In the early 2015, several cases of patients presenting symptoms of mild fever, rash, conjunctivitis and arthralgia were reported in the northeastern Brazil. Although all patients lived in a dengue endemic area, molecular and serological diagnosis for dengue resulted negative. Chikungunya virus infection was also discarded. Subsequently, Zika virus (ZIKV) was detected by reverse transcription-polymerase chain reaction from the sera of eight patients and the result was confirmed by DNA sequencing. Phylogenetic analysis suggests that the ZIKV identified belongs to the Asian clade. This is the first report of ZIKV infection in Brazil.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1506
[Cu] Class update date: 150817
[Lr] Last revision date:150817
[Js] Journal subset:IM
[St] Status:In-Process

  8 / 13319 MEDLINE  
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[PMID]: 25443753
[Au] Autor:Tanacs L; Littlefair E
[Ad] Address:Södra Älvsborgs Hospital Emergency Department Borås, Sweden.
[Ti] Title:Symptoms and treatment of acute conjunctivitis caused by skin secretions of veined tree frog (Trachycephalus venulosus).
[So] Source:Wilderness Environ Med;25(4):486-7, 2014 Dec.
[Is] ISSN:1545-1534
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Anura/physiology
Bodily Secretions
Conjunctivitis/etiology
[Mh] MeSH terms secundary: Adult
Animals
Anti-Bacterial Agents/administration & dosage
Conjunctivitis/diagnosis
Conjunctivitis/drug therapy
Humans
Male
Mexico
Skin
Tetracycline/administration & dosage
Young Adult
[Pt] Publication type:LETTER
[Nm] Name of substance:0 (Anti-Bacterial Agents); F8VB5M810T (Tetracycline)
[Em] Entry month:1508
[Js] Journal subset:IM
[Da] Date of entry for processing:141216
[St] Status:MEDLINE

  9 / 13319 MEDLINE  
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[PMID]: 25535199
[Au] Autor:Geier DA; Geier MR
[Ad] Address:Institute of Chronic Illnesses, Inc, 14 Redgate Ct, Silver Spring, MD, 20905, USA.
[Ti] Title:A case-control study of quadrivalent human papillomavirus vaccine-associated autoimmune adverse events.
[So] Source:Clin Rheumatol;34(7):1225-31, 2015 Jul.
[Is] ISSN:1434-9949
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:GARDASIL (Merck & Co., Inc., Whitehouse Station, NJ, USA) is a quadrivalent human papillomavirus (HPV4) vaccine. An epidemiological study was undertaken to evaluate concerns about the potential for HPV4 vaccination to induce serious autoimmune adverse events (SAAEs). The vaccine adverse event reporting system (VAERS) database was examined for adverse event reports associated with vaccines administered from January 2006 through December 2012 to recipients between 18 and 39 years old with a listed residence in the USA and a specified female gender. It was observed that cases with the SAAE outcomes of gastroenteritis (odds ratio (OR) = 4.6, 95% confidence interval (CI) = 1.3-18.5), arthritis (OR = 2.5, 95% CI = 1.4-4.3), systemic lupus erythematosus (OR = 5.3, 95% CI = 1.5-20.5), vasculitis (OR = 4, 95% CI = 1.01-16.4), alopecia (OR = 8.3, 95% CI = 4.5-15.9), or CNS conditions (OR = 1.8, 95% CI = 1.04-2.9) were significantly more likely than controls to have received HPV4 vaccine (median onset of SAAE symptoms from 6 to 55 days post-HPV4 vaccination). Cases with the outcomes of Guillain-Barre syndrome (OR = 0.75, 95% CI = 0.42-1.3) or thrombocytopenia (OR = 1.3, 95% CI = 0.48-3.5) were no more likely than controls to have received HPV4 vaccine. Cases with the general health outcomes of infection (OR = 0.72, 95% CI = 0.27-1.7), conjunctivitis (OR = 0.88, 95% CI = 0.29-2.7), or diarrhea (OR = 1.01, 95% CI = 0.83-1.22) were no more likely than controls to have received HPV4 vaccine. Previous case series of SAAEs and biological plausibility support the observed results. Additional studies should be conducted to further evaluate the potential biological mechanisms involved in HPV4 vaccine-associated SAAEs in animal model systems, and to examine the potential epidemiological relationship between HPV4 vaccine-associated SAAEs in other databases and populations.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1506
[Cu] Class update date: 150625
[Lr] Last revision date:150625
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1007/s10067-014-2846-1

  10 / 13319 MEDLINE  
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[PMID]: 24510061
[Au] Autor:Scarpioni R; Rigante D; Cantarini L; Ricardi M; Albertazzi V; Melfa L; Lazzaro A
[Ad] Address:Nephrology and Dialysis Unit, Department of Medicine, "Guglielmo da Saliceto" Hospital AUSL Piacenza, via Taverna 49, Piacenza, 29121, Italy, rscarpioni@hotmail.com.
[Ti] Title:Renal involvement in secondary amyloidosis of Muckle-Wells syndrome: marked improvement of renal function and reduction of proteinuria after therapy with human anti-interleukin-1ß monoclonal antibody canakinumab.
[So] Source:Clin Rheumatol;34(7):1311-6, 2015 Jul.
[Is] ISSN:1434-9949
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Muckle-Wells syndrome (MWS) is a rare hereditary autoinflammatory disorder characterized by recurrent urticaria-like skin rashes, arthralgias, conjunctivitis, hypoacusia, and risk of reactive AA amyloidosis due to the progressive accumulation of amyloid fibrils in different organs. Its genetic defect lies in mutations in the NLRP3 gene, encoding the cryopyrin protein, and resulting in interleukin (IL)-1ß oversecretion. Renal involvement, in terms of proteinuria or renal insufficiency, can be observed in up to 25% of patients. Herein, we describe our experience with two Caucasian patients, father and son, aged 52 and 26 years, respectively, heterozygous for both V198M and R260W NLRP3 mutations who had AA amyloid deposits on renal biopsy. The fully human monoclonal antibody canakinumab, providing selective and prolonged IL-1ß blockade, was administered in both patients every 60 days over a period of 18 months. This treatment allowed to obtain amazing results: a rapid disappearance of any clinical symptoms, the stable normalization of serum amyloid-A and, furthermore, a marked improvement of glomerular filtration rate and proteinuria with no adverse events. Our data, though limited to only two patients, emphasize that therapeutic intervention with canakinumab, suppressing both inflammation and IL-1ß-mediated manifestations, can contribute to improve kidney function in MWS with overt renal amyloidosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1506
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1007/s10067-013-2481-2


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