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[PMID]: 26875004
[Au] Autor:Callaway NF; Ludwig CA; Blumenkranz MS; Jones JM; Fredrick DR; Moshfeghi DM
[Ad] Address:Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California....
[Ti] Title:Retinal and Optic Nerve Hemorrhages in the Newborn Infant: One-Year Results of the Newborn Eye Screen Test Study.
[So] Source:Ophthalmology;123(5):1043-52, 2016 May.
[Is] ISSN:1549-4713
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To report the birth prevalence, risk factors, characteristics, and location of fundus hemorrhages (FHs) of the retina and optic nerve present in newborns at birth. DESIGN: Prospective cohort study at Stanford University School of Medicine. PARTICIPANTS: All infants who were 37 weeks postmenstrual age or older and stable were eligible for screening. Infants with known or suspected infectious conjunctivitis were excluded. METHODS: Infants born at Lucile Packard Children's Hospital (LPCH) from July 25, 2013, through July 25, 2014, were offered universal newborn screening via wide-angle digital retinal photography in the Newborn Eye Screen Test study. Maternal, obstetric, and neonatal factors were obtained from hospital records. The location, retinal layer, and laterality of FH were recorded by 1 pediatric vitreoretinal specialist. MAIN OUTCOME MEASURES: Birth prevalence of FH. Secondary outcomes included rate of adverse events, risk factors for FH, hemorrhage characteristics, and adverse events. RESULTS: The birth prevalence of FH in this study was 20.3% (41/202 infants). Ninety-five percent of FHs involved the periphery, 83% involved the macula, and 71% involved multiple layers of the retina. The fovea was involved in 15% of FH cases (birth prevalence, 3.0%). No cases of bilateral foveal hemorrhage were found. Fundus hemorrhages were more common in the left eye than the right. Fundus hemorrhages were most commonly optic nerve flame hemorrhages (48%) and white-centered retinal hemorrhages (30%). Retinal hemorrhages were found most frequently in all 4 quadrants (35%) and more often were multiple than solitary. Macular hemorrhages most often were intraretinal (40%). Among the risk factors examined in this study, vaginal delivery compared with cesarean section (odds ratio [OR], 9.34; 95% confidence interval [CI], 2.57-33.97) showed the greatest level of association with FH. Self-identified ethnicity as Hispanic or Latino showed a protective effect (OR, 0.43; 95% CI, 0.20-0.94). Other study factors were not significant. CONCLUSIONS: Fundus hemorrhages are common among newborns. They often involve multiple areas and layers of the retina. Vaginal delivery was associated with a significantly increased risk of FH, whereas self-identified Hispanic or Latino ethnicity was protective against FH in this study. The long-term consequences of FH on visual development remain unknown.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1604
[Js] Journal subset:IM
[St] Status:In-Data-Review

  2 / 13641 MEDLINE  
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[PMID]: 27070912
[Au] Autor:Brasil P; Calvet GA; Siqueira AM; Wakimoto M; de Sequeira PC; Nobre A; Quintana Mde S; Mendonça MC; Lupi O; de Souza RV; Romero C; Zogbi H; Bressan Cda S; Alves SS; Lourenço-de-Oliveira R; Nogueira RM; Carvalho MS; de Filippis AM; Jaenisch T
[Ad] Address:Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases; Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil....
[Ti] Title:Zika Virus Outbreak in Rio de Janeiro, Brazil: Clinical Characterization, Epidemiological and Virological Aspects.
[So] Source:PLoS Negl Trop Dis;10(4):e0004636, 2016 Apr.
[Is] ISSN:1935-2735
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: In 2015, Brazil was faced with the cocirculation of three arboviruses of major public health importance. The emergence of Zika virus (ZIKV) presents new challenges to both clinicians and public health authorities. Overlapping clinical features between diseases caused by ZIKV, Dengue (DENV) and Chikungunya (CHIKV) and the lack of validated serological assays for ZIKV make accurate diagnosis difficult. METHODOLOGY / PRINCIPAL FINDINGS: The outpatient service for acute febrile illnesses in Fiocruz initiated a syndromic clinical observational study in 2007 to capture unusual presentations of DENV infections. In January 2015, an increase of cases with exanthematic disease was observed. Trained physicians evaluated the patients using a detailed case report form that included clinical assessment and laboratory investigations. The laboratory diagnostic algorithm included assays for detection of ZIKV, CHIKV and DENV. 364 suspected cases of Zika virus disease were identified based on clinical criteria between January and July 2015. Of these, 262 (71.9%) were tested and 119 (45.4%) were confirmed by the detection of ZIKV RNA. All of the samples with sequence information available clustered within the Asian genotype. CONCLUSIONS / SIGNIFICANCE: This is the first report of a ZIKV outbreak in the state of Rio de Janeiro, based on a large number of suspected (n = 364) and laboratory confirmed cases (n = 119). We were able to demonstrate that ZIKV was circulating in Rio de Janeiro as early as January 2015. The peak of the outbreak was documented in May/June 2015. More than half of the patients reported headache, arthralgia, myalgia, non-purulent conjunctivitis, and lower back pain, consistent with the case definition of suspected ZIKV disease issued by the Pan American Health Organization (PAHO). However, fever, when present, was low-intensity and short-termed. In our opinion, pruritus, the second most common clinical sign presented by the confirmed cases, should be added to the PAHO case definition, while fever could be given less emphasis. The emergence of ZIKV as a new pathogen for Brazil in 2015 underscores the need for clinical vigilance and strong epidemiological and laboratory surveillance.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1604
[Cu] Class update date: 160423
[Lr] Last revision date:160423
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1371/journal.pntd.0004636

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[PMID]: 24081481
[Au] Autor:Cicciù M; Chiera F; Gallizzi R; Cicciù A; Salpietro CD
[Ad] Address:Human Pathology Department, Dental School, Messina University, Via Consolare Valeria, 98100, Messina, Italy, acromarco@yahoo.it.
[Ti] Title:Immunoglobulin injection for the treatment of multiple oral ulcers in Stevens-Johnson syndrome.
[So] Source:Eur Arch Paediatr Dent;14(5):355-8, 2013 Oct.
[Is] ISSN:1818-6300
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Stevens-Johnson syndrome (SJS) is a rare genetic disorder. The syndrome presents with severe purulent conjunctivitis, stomatitis with mucosal necrosis, and purpuric macules. This syndrome is associated with hypersensitive reaction usually stimulated by infection, vaccination, systemic diseases, physical agents, foods or drugs. However, only few cases reported can be related to infectious agents, but the causative role of infectious microorganisms seems relevant in paediatric patients. Authors want to underline the positive response of a new way of therapy by immunoglobulin injection. CASE REPORT: This case describes a 10-year-old girl with several erosions disseminated in the oral cavity mucosa. The girl had skin erosions that led to the clinical diagnosis of SJS. The past medical history of the patient revealed that those symptoms occured every 6 months over the last 2 years with 2 consecutive weeks of acute manifestations. At that moment, the paediatrician decided for cortisone administration in order to manage the acute symptoms, but after 6 months a new acute episode was observed. For this reason the patient was referred to the Department of Genetics and Immunological Paediatrics. TREATMENT: Oral ulcers had been topically treated with an oral balance gel. Intravenous injection of immunoglobulin was then applied and the patient was discharged after 5 days of treatment with the total symptoms in remission. FOLLOW-UP: The patient was followed up 3 monthly over the next 24 months. At that time no relapse of the SJS was observed. CONCLUSION: The seriousness of this condition imposes a prompt recognition. Paediatric dentists should recognise the clinical signs of possible SJS as soon as possible in order to perform a quick diagnosis and initiate treatment.
[Mh] MeSH terms primary: Oral Ulcer
Stevens-Johnson Syndrome
[Mh] MeSH terms secundary: Humans
Immunoglobulins
Recurrence
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Immunoglobulins)
[Em] Entry month:1604
[Js] Journal subset:D; IM
[Da] Date of entry for processing:131018
[St] Status:MEDLINE
[do] DOI:10.1007/s40368-013-0086-8

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[PMID]: 24007990
[Au] Autor:Sánchez-Caraballo J; Diez-Zuluaga S; Cardona-Villa R
[Ad] Address:Grupo de AlergologÌa ClÌnica y Experimental (GACE), Universidad de Antioquia, MedellÌn Colombia. jotamsc@yahoo.com.
[Ti] Title:Sensibilización a aeroalergenos en pacientes alérgicos de Medellín, Colombia. [Sensitization to aeroallergens in allergic patients from Medellin, Colombia].
[So] Source:Rev Alerg Mex;59(3):139-47, 2012 Jul-Sep.
[Is] ISSN:0002-5151
[Cp] Country of publication:Mexico
[La] Language:spa
[Ab] Abstract:BACKGROUND: Allergen sensitization is the first step in the onset of allergic diseases. Sensitizing sources may vary among geographic region but identification is needed to develop effective treatment as specific avoidance measures and immunotherapy. OBJECTIVE: To determine the prevalence of sensitization to several sources of aeroallergens by prick skin tests, in a group of patients with rhinitis, conjunctivitis, asthma or atopic dermatitis in a tropical city. METHODS: We reviewed the medical records of patients and their results of skin prick tests with aeroallergens, including Dermatophagoides pteronyssinus and Dermatophagoides farina, during the period of January 2008 to December 2011. RESULTS: Three hundred allergic patients with sensitization to 30 different allergens were included. House dust mites (78%), dog dander (47%) and cockroach (21.5%) were the most frequent positive allergens. We observed a significative sensitization pattern with house dust mites, dog dander, molds and piggeon droppings, associated with systemic allergic sensitization. CONCLUSIONS: As we expect, mites are the main source of sensitization in Medellin. However, other sources common in other regions such as the pollen grains are rare. The identification of the sources could help to predict in young children allergic phenotypes.
[Mh] MeSH terms primary: Allergens
Skin Tests
[Mh] MeSH terms secundary: Animals
Asthma/epidemiology
Colombia
Humans
Hypersensitivity/epidemiology
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Name of substance:0 (Allergens)
[Em] Entry month:1604
[Js] Journal subset:IM
[Da] Date of entry for processing:130906
[St] Status:MEDLINE

  5 / 13641 MEDLINE  
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[PMID]: 23390905
[Au] Autor:Ozüberk OÖ; Gökahmetoglu S; Ozçelik B; Ekmekçioglu O
[Ad] Address:Erciyes University Faculty of Medicine, Department of Medical Microbiology, Kayseri, Turkey. selmagk@gmail.com.
[Ti] Title:Semptomatik Hastalarin Genital Sürüntü Örneklerinde Hücre Kültürü, DFA ve PCR Yöntemleriyle Chlamydia trachomatis'in Arastirilmasi [Investigation of Chlamydia trachomatis with Cell Culture, DFA and PCR Methods in the Genital Swab Samples of Symptomatic Patients].
[So] Source:Mikrobiyol Bul;47(1):79-86, 2013 Jan.
[Is] ISSN:0374-9096
[Cp] Country of publication:Turkey
[La] Language:tur
[Ab] Abstract:Chlamydia trachomatis infection is considered the most prevalent bacterial sexually transmitted disease worldwide. C.trachomatis causes eye infections such as trachoma and newborn inclusion conjunctivitis, newborn pneumonia, genitourinary system infections and suppurative inguinal lymphadenitis namely lymphogranuloma venerum. The aim of this study was to investigate C.trachomatis by direct fluorescent antibody (DFA), polymerase chain reaction (PCR) and cell culture methods in the clinical samples sent to the microbiology laboratory with the prediagnosis of genital infections. A total of 50 swab samples obtained from adult patients (49 female, 1 male) who were admitted to Erciyes University Hospital, Kayseri, Turkey between February-March 2010, were included in the study. C.trachomatis antigens were investigated by a commercial DFA (PathoDx, Remel, USA) method. McCoy cell cultures prepared in microplate wells were used for the isolation of C.trachomatis. The growth of C.trachomatis in cell cultures was confirmed by DFA and iodine staining methods. C.trachomatis DNA was investigated by commercially available PCR (Chlamydia trachomatis 330/740 IC; Sacace, Italy) method. In our study, 4 (8%) of the 50 swab samples were found positive with DFA, 1 (2%) was positive with cell culture, and 1 (2%) was positive with PCR. The only sample that gave positive results with all of the three methods was an urethral swab. Three cervical swab samples that were found positive only with DFA method was evaluated as false positivity. When cell culture was considered as the reference method, the sensitivity and specificity of DFA method were estimated as 100% and 94%, respectively, while those rates for PCR were 100% and 100%, respectively. In conclusion, although cell culture is still the gold standard in the diagnosis of C.trachomatis. infections, since it is time consuming and difficult to apply, more rapid and reliable PCR methods may be applied in diagnosis. DFA method which is practical and cheap, is preferred largely in routine laboratory practice. However, false negative and false positive DFA results should be prevented by the maintainence of good quality clinical specimens, evaluation of the test by experienced personnel and use of quality control samples in each run.
[Mh] MeSH terms primary: Chlamydia Infections
Chlamydia trachomatis
[Mh] MeSH terms secundary: Chlamydia Infections/microbiology
Fluorescent Antibody Technique, Direct
Humans
Polymerase Chain Reaction
Sensitivity and Specificity
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1604
[Js] Journal subset:IM
[Da] Date of entry for processing:130208
[St] Status:MEDLINE

  6 / 13641 MEDLINE  
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[PMID]: 27101541
[Au] Autor:Dasgupta S; Reagan-Steiner S; Goodenough D; Russell K; Tanner M; Lewis L; Petersen EE; Powers AM; Kniss K; Meaney-Delman D; Oduyebo T; O'Leary D; Chiu S; Talley P; Hennessey M; Hills S; Cohn A; Gregory C; Zika Virus Response Epidemiology and Laboratory Team; CDC; CDC (all these individuals meet collaborator criteria
[Ti] Title:Patterns in Zika Virus Testing and Infection, by Report of Symptoms and Pregnancy Status - United States, January 3-March 5, 2016.
[So] Source:MMWR Morb Mortal Wkly Rep;65(15):395-9, 2016.
[Is] ISSN:1545-861X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:CDC recommends Zika virus testing for potentially exposed persons with signs or symptoms consistent with Zika virus disease, and recommends that health care providers offer testing to asymptomatic pregnant women within 12 weeks of exposure. During January 3-March 5, 2016, Zika virus testing was performed for 4,534 persons who traveled to or moved from areas with active Zika virus transmission; 3,335 (73.6%) were pregnant women. Among persons who received testing, 1,541 (34.0%) reported at least one Zika virus-associated sign or symptom (e.g., fever, rash, arthralgia, or conjunctivitis), 436 (9.6%) reported at least one other clinical sign or symptom only, and 2,557 (56.4%) reported no signs or symptoms. Among 1,541 persons with one or more Zika virus-associated symptoms who received testing, 182 (11.8%) had confirmed Zika virus infection. Among the 2,557 asymptomatic persons who received testing, 2,425 (94.8%) were pregnant women, seven (0.3%) of whom had confirmed Zika virus infection. Although risk for Zika virus infection might vary based on exposure-related factors (e.g., location and duration of travel), in the current setting in U.S. states, where there is no local transmission, most asymptomatic pregnant women who receive testing do not have Zika virus infection.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1604
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.15585/mmwr.mm6515e1

  7 / 13641 MEDLINE  
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[PMID]: 26894619
[Au] Autor:Panchal B; Eddleston M; Thomas SH; Thompson JP; Vale JA
[Ad] Address:a NPIS (Birmingham Unit), City Hospital , Birmingham , UK ;...
[Ti] Title:754 exposures to reed diffusers reported to the United Kingdom National Poisons Information Service 2010-2014.
[So] Source:Clin Toxicol (Phila);54(4):333-8, 2016 Apr.
[Is] ISSN:1556-9519
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The objective of this study is to review the reported toxicity of reed diffuser fragrance liquid which, in addition to essential oils, commonly contains glycol ethers but other ingredients and/or alternatives are 3-methoxy-3-methyl-1-butanol, petroleum distillates, ethanol and isopropanol. METHODS: We analysed retrospectively enquiries to the United Kingdom National Poisons Information Service between 1 January 2010 and 31 December 2014. RESULTS: 754 patients were exposed to reed diffusers; the majority (n = 712) were children < 5 years. Ingestion was the most common route of exposure (706 of 754 patients) and involved the liquid alone (n = 570), water beads alone (n = 84), sucking on the reeds (n = 31) or ingesting the liquid and water beads (n = 21). The reported amount of fragrance liquid ingested was known in only 76 of 591 cases (12.9%), with a median (IQR) volume of 20.0 (IQR = 10-40) mL. The WHO/IPCS/EC/EAPCCT Poisoning Severity Score (PSS) was known in 702 of 706 sole ingestions: in 574 (81.3%), the PSS was 0 (asymptomatic); in 117 (16.6%) patients, the PSS was 1 (minor toxicity); in 11 (1.6%), the PSS was 2 (moderate toxicity); there were no patients with features graded PSS 3 (severe toxicity). Significantly (p = 0.008) more patients became symptomatic (PSS 1 and PSS 2) following the ingestion of a reed diffuser containing 3-methoxy-3-methyl-1-butanol than propylene glycol monobutyl ether, though there was no significant difference when compared with those containing dipropylene glycol monomethyl ether (p = 0.181). The most common features following ingestion of fragrance liquid were nausea and vomiting (n = 53), coughing (n = 17) and CNS depression (n = 9). Seven patients suffered eye exposure alone: two developed eye pain and four conjunctivitis. Dermal exposure alone was reported in six patients, two of whom developed skin irritation. CONCLUSIONS: The majority of patients in our study developed no features or only minor symptoms following ingestion of reed diffuser fragrance liquid.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1604
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.3109/15563650.2016.1140772

  8 / 13641 MEDLINE  
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[PMID]: 27101674
[Au] Autor:Wang R; Zhang C
[Ti] Title:[Clinical evaluation of Montelukast plus Budesonide nasal spray and Desloratadine citrate disodium in treating moderate and severe persistent allergic rhinitis].
[So] Source:Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;29(23):2041-3, 2015 Dec.
[Is] ISSN:1001-1781
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To investigate the clinical efficacy of montelukast plus budesonide nasal spray and desloratadine citrate disodium tablets on moderate and severe persistent allergic rhinitis. METHOD: Senenty patients with moderate and severe persistent allergic rhinitis were devided randomly study group (n = 35) and control group (n = 35). The study group were treated with montelukast sodium tablets combined with budesonide nasal spray and desloratadine citrate disodium tablets for 4 weeks, the control group received budesonide nasal spray and desloratadine citrate disodium tablets for 4 weeks. Comparing visual analogue scale (VAS) scores of nasal symptoms, rhino conjunctivitis quality of life questionnaire (RQLQ) scores and total effective rate in two groups at baseline and after treatment. RESULT: (1) VAS scores of nasal symptoms: the difference of total nasal symptoms VAS scores or single nasal symptom VAS scores from both groups at 2 weeks and 4 weeks after treatment were statistically significant (P < 0.05); (2) RQLQ scores: the difference of RQLQ scores of 2 group's at baseline and 4 weeks after treatment were statistically significant, the difference of RQLQ scores about nasal symptoms in two groups at 4 weeks after treatment were statistically significant (P < 0.05); (3) The total effective rate was 94.29% in study group but 80.00% in control group, the differences were statistically significant (P < 0.05). CONCLUSION: Montelukast plus budesonide nasal spray and desloratadine citrate disodium tablets can work together better on relieving clinical syptoms quickly and promoting the life quality of patients with moderate and severe persistent allergic rhinitis.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1604
[Js] Journal subset:IM
[St] Status:In-Process

  9 / 13641 MEDLINE  
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[PMID]: 27092227
[Au] Autor:Demiray T; Aydemir OA; Koroglu M; Ozbek A; Altindis M
[Ad] Address:Department of Clinical Microbiology, Sakarya Research and Training Hospital, Sakarya, Turkey....
[Ti] Title:A severe Morganella morganii endophthalmitis; followed by bacteremia.
[So] Source:Iran J Microbiol;8(1):70-2, 2016 Feb.
[Is] ISSN:2008-3289
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:Morganella morganii is rarely isolated from nosocomial infections. However, postoperative infections due to Morganella spp. were documented in literature and eye involvements of the infections usually result in severe sequels. We present a severe case infection, which was caused by M. morganii subsp. morganii, firstly appearing as conjunctivitis and complicated by bacteremia. The infectious agent isolated from both conjunctival and consecutive blood cultures. Identification and antimicrobial susceptibility tests were performed with the Vitek 2(®) automated system. The isolate was resistant to cephalosporins and carbapenems and it had ability to produce extended spectrum beta-lactamases. Patient was successfully treated with intravenous ciprofloxacin according to susceptibility test results. This is the first report of M. morganii infection detected as a local infection then complicated by bacteremia.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1604
[Cu] Class update date: 160421
[Lr] Last revision date:160421
[Da] Date of entry for processing:160419
[St] Status:PubMed-not-MEDLINE

  10 / 13641 MEDLINE  
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[PMID]: 26472169
[Au] Autor:Wang XQ; Ke X; Shen Y; Kang HY; Gu Z; Hu GH; Hong SL
[Ad] Address:a Department of Otorhinolaryngology-Head and Neck Surgery , the First Affiliated Hospital of Chongqing Medical University , Chongqing , PR China....
[Ti] Title:Changes in circulating follicular helper T-cells in Chinese patients with allergic rhinitis.
[So] Source:Acta Otolaryngol;136(2):199-204, 2016.
[Is] ISSN:1651-2251
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:CONCLUSIONS: Changes of circulating Follicular helper T (cTfh) cells existed in allergic rhinitis (AR) patients, and the severity of disease was associated with a more severe change of cTfh milieu. These results imply that cTfh cells may play a crucial role in the pathology of AR in Chinese patients. OBJECTIVES: The aim of this study was to investigate the changes in cTfh cells in Chinese AR patients. METHODS: Fifty-two patients were studied (32 in the AR group and 20 in the control group) for this research. The cTfh cell frequency and mRNA levels of transcription factor Bcl-6, B lymphocyte induced maturation protein 1 (BLIMP-1), and related cytokine IL-21 (IL-21 protein was also measured) were analyzed. Clinical severity was evaluated by total serum IgE levels, visual analog scale scores (VAS), and rhino-conjunctivitis quality-of-life questionnaires (RQLQ). RESULTS: The frequency of cTfh cells were elevated in AR groups vs healthy controls (p < 0.05). Levels of IL-21 mRNA, Bcl-6 mRNA and the level of IL-21 protein were also significantly higher in the AR groups (p < 0.05), whereas BLIMP-1 mRNA was decreased (p < 0.05). Furthermore, positive correlations were identified between the frequency of cTfh cells and indicators of clinical severity (p < 0.01).
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1601
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.3109/00016489.2015.1093169


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