Database : MEDLINE
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[PMID]: 25590460
[Au] Autor:Fehily SR; Cross GB; Fuller AJ
[Ad] Address:Infectious Disease Unit, Alfred Hospital, Melbourne, Australia.
[Ti] Title:Bilateral conjunctivitis in a returned traveller.
[So] Source:PLoS Negl Trop Dis;9(1):e0003351, 2015 Jan.
[Is] ISSN:1935-2735
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150122
[Lr] Last revision date:150122
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1371/journal.pntd.0003351

  2 / 13073 MEDLINE  
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[PMID]: 25244402
[Au] Autor:Heller W; Cruz M; Bhagat YR; De Leon JM; Felix C; Villanueva L; Hollander DA; Jensen H
[Ad] Address:1 Arizona Center for Clinical Trials , Phoenix, Arizona.
[Ti] Title:Gatifloxacin 0.5% administered twice daily for the treatment of acute bacterial conjunctivitis in patients one year of age or older.
[So] Source:J Ocul Pharmacol Ther;30(10):815-22, 2014 Dec.
[Is] ISSN:1557-7732
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To evaluate the efficacy and safety of gatifloxacin 0.5% ophthalmic solution administered twice daily for treatment of acute bacterial conjunctivitis. METHODS: Two identically designed, double-masked, multicenter studies in the United States and India enrolled patients 1 year or older with acute bacterial conjunctivitis. Patients were randomized to gatifloxacin 0.5% or vehicle treatment for 5 days. Clinical success in clearing conjunctival hyperemia and discharge at day 6 (primary endpoint) and day 4 and microbiological cure were determined. Isolates from positive conjunctival samples were tested for sensitivity and susceptibility. Safety measures included adverse events (AEs). Data from these 2 studies were pooled for these analyses. RESULTS: Of the 1437 randomized patients, 658 constituted the modified intent-to-treat population. Patient characteristics were similar between the pooled treatment groups. Clinical success occurred for 58.0% of gatifloxacin 0.5%-treated versus 45.5% vehicle-treated patients at day 6 (P=0.001) and for 23.7% versus 15.4% in the respective groups at day 4 (P=0.007). Microbiological cure was higher with gatifloxacin 0.5% than vehicle at days 4 and 6 (P<0.001 for both time points). The combined minimum inhibitory concentration required to inhibit 90% of isolates for gatifloxacin 0.5% was 2.0 µg/mL for gram-positive and gram-negative organisms. AEs were reported by 11.6% and 13.3% of patients in the gatifloxacin 0.5% and vehicle safety populations, respectively. One patient in each treatment group experienced a serious AE; neither was treatment related. CONCLUSIONS: The 0.5% concentration of gatifloxacin ophthalmic solution was safe and effective for treatment of acute bacterial conjunctivitis with twice-daily administration for 5 days.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1089/jop.2014.0040

  3 / 13073 MEDLINE  
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[PMID]: 24761804
[Au] Autor:Pfaar O; Demoly P; Gerth van Wijk R; Bonini S; Bousquet J; Canonica GW; Durham SR; Jacobsen L; Malling HJ; Mösges R; Papadopoulos NG; Rak S; Rodriguez del Rio P; Valovirta E; Wahn U; Calderon MA; European Academy of Allergy and Clinical Immunology
[Ad] Address:Center for Rhinology and Allergology Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim, Germany.
[Ti] Title:Recommendations for the standardization of clinical outcomes used in allergen immunotherapy trials for allergic rhinoconjunctivitis: an EAACI Position Paper.
[So] Source:Allergy;69(7):854-67, 2014 Jul.
[Is] ISSN:1398-9995
[Cp] Country of publication:Denmark
[La] Language:eng
[Ab] Abstract:BACKGROUND: Allergen immunotherapy (AIT) has been thoroughly documented in randomized controlled trials (RCTs). It is the only immune-modifying and causal treatment available for patients suffering from IgE-mediated diseases such as allergic rhinoconjunctivitis, allergic asthma and insect sting allergy. However, there is a high degree of clinical and methodological heterogeneity among the endpoints in clinical studies on AIT, for both subcutaneous and sublingual immunotherapy (SCIT and SLIT). At present, there are no commonly accepted standards for defining the optimal outcome parameters to be used for both primary and secondary endpoints. METHODS: As elaborated by a Task Force (TF) of the European Academy of Allergy and Clinical Immunology (EAACI) Immunotherapy Interest Group, this Position Paper evaluates the currently used outcome parameters in different RCTs and also aims to provide recommendations for the optimal endpoints in future AIT trials for allergic rhinoconjunctivitis. RESULTS: Based on a thorough literature review, the TF members have outlined recommendations for nine domains of clinical outcome measures. As the primary outcome, the TF recommends a homogeneous combined symptom and medication score (CSMS) as a simple and standardized method that balances both symptoms and the need for antiallergic medication in an equally weighted manner. All outcomes, grouped into nine domains, are reviewed. CONCLUSION: A standardized and globally harmonized method for analysing the clinical efficacy of AIT products in RCTs is required. The EAACI TF highlights the CSMS as the primary endpoint for future RCTs in AIT for allergic rhinoconjunctivitis.
[Mh] MeSH terms primary: Allergens/immunology
Conjunctivitis, Allergic/prevention & control
Desensitization, Immunologic/standards
Rhinitis, Allergic/prevention & control
[Mh] MeSH terms secundary: Humans
[Pt] Publication type:JOURNAL ARTICLE; PRACTICE GUIDELINE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Allergens)
[Em] Entry month:1501
[Cu] Class update date: 141224
[Lr] Last revision date:141224
[Js] Journal subset:IM
[Da] Date of entry for processing:140606
[St] Status:MEDLINE
[do] DOI:10.1111/all.12383

  4 / 13073 MEDLINE  
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[PMID]: 25281489
[Au] Autor:Tananuvat N; Charoenkwan P; Ohazama A; Ketuda Cairns JR; Kaewgahya M; Kantaputra PN
[Ad] Address:Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand....
[Ti] Title:Root dentin anomaly and a PLG mutation.
[So] Source:Eur J Med Genet;57(11-12):630-5, 2014 Nov-Dec.
[Is] ISSN:1878-0849
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:We report a Thai girl affected with plasminogen deficiency, Type I. Ligneous conjunctivitis was first observed when she was one-month-old. The newly recognized findings include tapered incisor roots as a result of thin root dentin, generalized short tooth roots, and mandibular prognathism. Mutation analysis of PLG demonstrated homozygous c.1193G>A missense mutation. The parents were heterozygous for c.1193G>A mutation. The c.1193G>A mutation is novel and predicted to cause amino acid substitution p.Cys398Tyr. Thin root dentin in the patient who was affected with PLG mutation and immunolocalization of Plg during early root development in mice imply the role of plasminogen in root dentin formation.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Process

  5 / 13073 MEDLINE  
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[PMID]: 24906343
[Au] Autor:Ecochard-Dugelay E; Beliah M; Perreaux F; de Laveaucoupet J; Bouyer J; Epaud R; Labrune P; Ducou-Lepointe H; Gajdos V
[Ti] Title:Clinical predictors of radiographic abnormalities among infants with bronchiolitis in a paediatric emergency department.
[So] Source:BMC Pediatr;14:143, 2014.
[Is] ISSN:1471-2431
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Acute viral respiratory exacerbation is one of the most common conditions encountered in a paediatric emergency department (PED) during winter months. We aimed at defining clinical predictors of chest radiography prescription and radiographic abnormalities, among infants with bronchiolitis in a paediatric emergency department. METHODS: We conducted a prospective cohort study of children less than 2 years of age with clinical bronchiolitis, who presented for evaluation at the paediatric emergency department of an urban general hospital in France. Detailed information regarding historical features, examination findings, and management were collected. Clinical predictors of interest were explored in multivariate logistic regression models. RESULTS: Among 410 chest radiographs blindly interpreted by two experts, 40 (9.7%) were considered as abnormal. Clinical predictors of chest radiography achievement were age (under three months), feeding difficulties, fever over 38°C, hypoxia under than 95% of oxygen saturation, respiratory distress, crackles, and bronchitis rales. Clinical predictors of radiographic abnormalities were fever and close to significance hypoxia and conjunctivitis. CONCLUSION: Our study provides arguments for reducing chest radiographs in infants with bronchiolitis. For infants with clinical factors such as age less than three months, feeding difficulties, respiratory distress without hypoxia, isolated crackles or bronchitis rales, careful clinical follow-up should be provided instead of chest radiography.
[Mh] MeSH terms primary: Bronchiolitis/radiography
[Mh] MeSH terms secundary: Anoxia/epidemiology
Bronchiolitis/epidemiology
Bronchitis/epidemiology
Conjunctivitis/epidemiology
Emergency Service, Hospital
Feeding Behavior
Female
Fever/epidemiology
Humans
Infant
Male
Multivariate Analysis
Otitis/epidemiology
Prospective Studies
Respiratory Insufficiency/epidemiology
Respiratory Sounds
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Js] Journal subset:IM
[Da] Date of entry for processing:140612
[St] Status:MEDLINE
[do] DOI:10.1186/1471-2431-14-143

  6 / 13073 MEDLINE  
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[PMID]: 25606121
[Au] Autor:Mallika P; Asok T; Faisal H; Aziz S; Tan A; Intan G
[Ti] Title:Neonatal conjunctivitis - a review.
[So] Source:Malays Fam Physician;3(2):77-81, 2008.
[Is] ISSN:1985-207X
[Cp] Country of publication:Malaysia
[La] Language:eng
[Ab] Abstract:Ophthalmia neonatorum remains a significant cause of ocular morbidity, blindness and even death in underdeveloped countries. The organisms causing ophthalmia neonatorum are acquired mainly from the mother's birth canal during delivery and a small percentage of cases are acquired by other ways. Chlamydia and Neisseria are the most common pathogens responsible for the perinatal infection. Fortunately in most cases, laboratory studies can identify the causative organism and unlike other form of conjunctivitis, this perinatal ocular infection has to be treated with systemic antibiotics to prevent systemic colonization of the organism. Routine prophylaxis with 1% silver nitrate solution (crédés method) has been discontinued in many developed nations for the fear of development of chemical conjunctivitis.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1501
[Da] Date of entry for processing:150121
[St] Status:PubMed-not-MEDLINE

  7 / 13073 MEDLINE  
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[PMID]: 25196311
[Au] Autor:Erdin BN; Pas SD; Durak I; Schutten M; Sayiner AA
[Ad] Address:Department of Microbiology, Van Regional Research and Training Hospital, Van, Turkey.
[Ti] Title:A 5-year study of adenoviruses causing conjunctivitis in Izmir, Turkey.
[So] Source:J Med Virol;87(3):472-7, 2015 Mar.
[Is] ISSN:1096-9071
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Adenoviruses are a common cause of conjunctivitis. Genotypes are diverse and differ according to population and geographical distribution of the virus. There is limited data regarding ocular adenoviral infections and genotype distribution in Turkey. This study aimed to determine the adenovirus genotypes and their epidemiological features among patients with conjunctivitis between 2006 and 2010, in Izmir, Turkey. Adenoviral DNA was detected by PCR in 213 of 488 (44%) of the ocular samples collected from patients with viral conjunctivitis during the 5-year study period. Of these, 101 (47%) were randomly chosen and genotyped by sequence analysis. Seven genotypes were identified, including 3, 4, 8, 11, 19, 37, and 53. Genotype 8 and 4 were the dominant types detected in 67 (66.3%) and 25 (24.7%) of the samples, respectively. Other five genotypes (3, 11, 19, 37, 53) were detected in 9 (8.9%) samples. Genotype and seasonal differences observed throughout the study. Human adenoviruse (HAdV)-8 was the most frequent type, except 2008. The prevalence of genotype 4 increased starting from 2006, became dominant in 2008 and decreased in the following years. The peak season was mostly spring months, although it was possible to detect positive samples throughout the year. In conclusion, genotype 8 followed by genotype 4 was the most frequent adenoviral types causing conjunctivitis during the 5-year study period. Findings suggest that there is a slow shift between genotypes throughout the years. J. Med. Virol. 87:472-477, 2015. © 2014 Wiley Periodicals, Inc.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1002/jmv.24071

  8 / 13073 MEDLINE  
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[PMID]: 25432143
[Au] Autor:DuBiner HB; Hubatsch DA
[Ad] Address:Clayton Eye Center, 1000 Corporate Center Drive, Suite 102, Morrow, GA 30260, USA. glaucdocatl@mindsping.com.
[Ti] Title:Late-day intraocular pressure-lowering efficacy and tolerability of travoprost 0.004% versus bimatoprost 0.01% in patients with open-angle glaucoma or ocular hypertension: a randomized trial.
[So] Source:BMC Ophthalmol;14:151, 2014.
[Is] ISSN:1471-2415
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Medications to control intraocular pressure (IOP) are frequently preserved using benzalkonium chloride (BAK), which can negatively affect the ocular surface. Data are needed to assess efficacy and safety of prostaglandin drugs preserved with and without BAK. The present study compared the efficacy and safety of BAK-free travoprost 0.004% (TRAV) and BAK 0.02%-preserved bimatoprost 0.01% (BIM) during late-day time points in patients with open-angle glaucoma or ocular hypertension. METHODS: This was a 12-week, phase 4, randomized, investigator-masked, crossover study. 84 patients with IOP ≥24 and <36 mmHg were randomized 1:1 to receive once-daily TRAV or BIM for 6 weeks followed by an additional 6-week crossover period. IOP was measured at the end of each treatment period at 4, 6, and 8 pm. TRAV was considered noninferior to BIM if the upper limit of the 95% CI of the between-group difference in mean IOP was ≤1.5 mmHg. Adverse events were assessed throughout the study. RESULTS: One patient discontinued due to allergic conjunctivitis, and 2 patients with missing data were excluded; 81 patients were included in the per-protocol population (mean ± SD age, 58.3 ± 11.4 years; TRAV/BIM, n = 41; BIM/TRAV, n = 40). After 6 weeks, mean IOP with TRAV (17.4 ± 2.7 mmHg; change from baseline, -6.0 mmHg) was similar to BIM (17.2 ± 2.6 mmHg; change from baseline, -6.3 mmHg); the between-group difference was 0.22 mmHg (95% CI, -0.22 to 0.67). Thus, noninferiority of TRAV versus BIM was demonstrated. Mean IOP at each time point and mean and percentage IOP change from baseline were not significantly different between treatments. All treatment-emergent adverse events were mild to moderate. The incidences of mild ocular hyperemia with TRAV and BIM were 31% and 39%, respectively; moderate hyperemia was observed in 2% of patients receiving BIM. CONCLUSION: Late-day IOP-lowering efficacy of BAK-free TRAV was noninferior to that of BAK 0.02%-preserved BIM; both reduced baseline IOP by 25%. Both treatments were well tolerated, although a higher incidence of moderate ocular hyperemia was observed with BIM. TRIAL REGISTRATION: ClinicalTrials.gov identifier, NCT01464424; registered November 1, 2011.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1412
[Cu] Class update date: 150120
[Lr] Last revision date:150120
[Js] Journal subset:IM
[Cl] Clinical Trial:ClinicalTrial
[St] Status:In-Process
[do] DOI:10.1186/1471-2415-14-151

  9 / 13073 MEDLINE  
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[PMID]: 25012226
[Au] Autor:Van Eldere J; Slack MP; Ladhani S; Cripps AW
[Ad] Address:Department of Microbiology and Immunology, Catholic University Leuven, Belgium; Clinical Department of Laboratory Medicine, University Hospital Leuven, Belgium. Electronic address: johan.vaneldere@uzleuven.be....
[Ti] Title:Non-typeable Haemophilus influenzae, an under-recognised pathogen.
[So] Source:Lancet Infect Dis;14(12):1281-92, 2014 Dec.
[Is] ISSN:1474-4457
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Non-typeable Haemophilus influenzae (NTHi) is a major cause of mucosal infections such as otitis media, sinusitis, conjunctivitis, and exacerbations of chronic obstructive pulmonary disease. In some regions, a strong causal relation links this pathogen with infections of the lower respiratory tract. In the past 20 years, a steady but constant increase has occurred in invasive NTHi worldwide, with perinatal infants, young children, and elderly people most at risk. Individuals with underlying comorbidities are most susceptible and infection is associated with high mortality. ß-lactamase production is the predominant mechanism of resistance. However, the emergence and spread of ß-lactamase-negative ampicillin-resistant strains in many regions of the world is of substantial concern, potentially necessitating changes to antibiotic treatment guidelines for community-acquired infections of the upper and lower respiratory tract and potentially increasing morbidity associated with invasive NTHi infections. Standardised surveillance protocols and typing methodologies to monitor this emerging pathogen should be implemented. International scientific organisations need to raise the profile of NTHi and to document the pathobiology of this microbe.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Process

  10 / 13073 MEDLINE  
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[PMID]: 25395268
[Au] Autor:Krasny J; Hruba D; Netukova M
[Ti] Title:The Role of Chlamydia pneumoniae in the Etiology of Keratoconjunctivitis Sicca (KCS).
[So] Source:Recent Pat Inflamm Allergy Drug Discov;8(3):216-22, 2014.
[Is] ISSN:1872-213X
[Cp] Country of publication:United Arab Emirates
[La] Language:eng
[Ab] Abstract:AIM: The authors aimed to show the possible relationship between keratoconjunctivitis sicca (KCS) and Chlamydia pneumonia from the point of view of clinical and microbiological diagnostics. MATERIAL AND METHODS: 94 adult patients were treated for follicular conjunctivitis with symptoms of KCS with possible Chlamydia pneumoniae etiology. The diagnosis of a chlamydial infection is based on the serological positivity of chlamydia antibodies and is further based on the antigen positivity in conjunctival imprint preparations. Patients were treated with azithromycin for a period of 12 days. RESULTS: The reciprocal relationship between chlamydial infection and ocular symptoms was proved at 21 patients (22%). Ninety% of patients showed positive anti-Chlamydia pneumoniae IgA and/or IgM with positivity in 80%, including anti-LSP IgA and/or IgM antibodies. This finding was in correlation with the medium to strongly positive finding of anti-cHSP60 IgG. In two patients, this infection was confirmed by the positivity of Chlamydia pneumoniae DNA in peripheral leucocytes. The test group (100 healthy persons) showed 69% negative finding of anti-Chlamydia pneumoniae antibodies or only positive anamnestic antibodies (IgG) and 31% positive antibodies IgA or IgM without clinical sings. CONCLUSION: This study indicated the possible relationship between KCS and Chlamydia pneumoniae in the course of simultaneous clinical signs of follicular conjunctivitis. KCS is a consequence of the action of local infection at the surface of the conjunctiva. It also indicated the necessity of simultaneous evaluation of microbiological findings and the clinical picture in consideration of overall antibiotic treatment in view of the high antibody background of Chlamydia pneumoniae in the adult population in the Czech Republic. The authors aimed to show the possible relationship between the keratoconjunctivitis sicca and Chlamydia pneumoniae based on results of the two studies. Some patents on conjunctivitis are also briefly described in this article.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Js] Journal subset:IM
[St] Status:In-Data-Review


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