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[PMID]: | 28964874 | [Au] Autor: | Matos TS; Silva AKO; Quintela AL; Francisco das Chagas Pinto L; Canuto KM; Braz-Filho R; Fonseca MJS; Luna-Costa AM; Paz IA; Nascimento NRF; Silveira ER; Pessoa ODL |
[Ad] Address: | Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, 60971-270 Fortaleza, CE, Brazil. | [Ti] Title: | Neuroinhibitory meroterpenoid compounds from Cordia oncocalyx. | [So] Source: | Fitoterapia;123:65-72, 2017 Nov. | [Is] ISSN: | 1873-6971 | [Cp] Country of publication: | Netherlands | [La] Language: | eng | [Ab] Abstract: | Five new meroterpenoid compounds designed as rel-10ß,11ß-epoxy-2,11-dimethoxy-8α-hydroxy-8aß-methyl-5α,6,7,8,8a,9,10,10aß-octahydro-1,4-anthracendione (1), rel-10ß,11ß-epoxy-8α,5-dihydroxy-2-methoxy-8aß-methyl-5,6,7,8,8a,9,10,10aß-octahydro -1.4-anthracendione (2), rel-1,4,8α-trihydroxy-5-furanyl-2-methoxy-8aß-methyl-6,7,8, 8a,9,10-hexahydro-10-anthracenone (3), rel-10α,11α-epoxy-8α,11ß-dihydroxy-8aß-methyl-5ß,6,7,8,8a,9,10,10aß-octahydro-1,4-anthracenediol (4) and rel-1,4,8α-trihydroxy-5-carboxyethyl-2-methoxy-8aß-methyl-6,7,8,8a,9,10-hexahydro-10-anthra-cenone (5), besides seven (6-12) known compounds were isolated from the heartwood and sapwood ethanol extracts of Cordia oncocalyx. Moreover, the main isolated compounds were screened using the electrically driven mice vas deferens bioassay, which has a rich pharmacological receptors diversity. | [Pt] Publication type: | JOURNAL ARTICLE | [Em] Entry month: | 1710 | [Cu] Class update date: |
171115 | [Lr] Last revision date: | 171115 | [St] Status: | In-Process |
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