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[PMID]: 28627652
[Au] Autor:Liang Y; Niu H; Ma L; Du D; Wen L; Xia Q; Huang W
[Ad] Address:Laboratory of Ethnopharmacology, Department of Integrated Traditional Chinese and Western Medicine, Regenerative Medicine Research Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
[Ti] Title:Eriodictyol 7­O­ß­D glucopyranoside from Coreopsis tinctoria Nutt. ameliorates lipid disorders via protecting mitochondrial function and suppressing lipogenesis.
[So] Source:Mol Med Rep;16(2):1298-1306, 2017 Aug.
[Is] ISSN:1791-3004
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:Coreopsis tinctoria (snow chrysanthemum) has been reported to exert antihyperlipidemic effects. The present study aimed to identify the active compounds of Coreopsis tinctoria and to investigate the molecular mechanisms underlying its effects on lipid dysregulation by measuring lipid levels, reactive oxygen species, lipid peroxidation and fatty acid synthesis. The present results demonstrated that snow chrysanthemum aqueous extracts significantly reduced serum lipid levels and oxidative stress in vivo. The main compounds that were isolated were identified as flavanomarein (compound 1) and eriodictyol 7­O­ß­D glucopyranoside (compound 2). Compounds 1 and 2 demonstrated potent antioxidative properties, including free radical scavenging activity, inhibition of lipid peroxidation, as well as lipid­lowering effects in human HepG2 hepatocellular carcinoma cells treated with free fatty acids (FFAs). Compound 2 was revealed to suppress the elevation of triglyceride levels and inhibit lipid peroxidation following FFA treatment. In addition, it was demonstrated to significantly reduce intracellular levels of reactive oxygen species and improve the mitochondrial membrane potential and adenosine triphosphate levels, thus protecting mitochondrial function in FFA­treated HepG2 cells. Furthermore, compound 2 markedly suppressed the protein expression levels of disulfide­isomerase A3 precursor and fatty acid synthase, thus suppressing FFA­induced lipogenesis in HepG2 cells. In conclusion, the present study identified compound 2 as one of the main active compounds in Coreopsis tinctoria responsible for its lipid­lowering effects. Compound 2 was revealed to possess antihyperlipidemic properties, exerted via reducing oxidative stress, protecting mitochondrial function and suppressing lipogenesis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1706
[Cu] Class update date: 171024
[Lr] Last revision date:171024
[St] Status:In-Process
[do] DOI:10.3892/mmr.2017.6743

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[PMID]: 28681383
[Au] Autor:Deng Y; Lam SC; Zhao J; Li SP
[Ad] Address:State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, P. R. China.
[Ti] Title:Quantitative analysis of flavonoids and phenolic acid in Coreopsis tinctoria Nutt. by capillary zone electrophoresis.
[So] Source:Electrophoresis;38(20):2654-2661, 2017 Oct.
[Is] ISSN:1522-2683
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Capillary zone electrophoresis was developed for the simultaneous determination of five flavonoids and one phenolic acid, including taxifolin-7-O-glucoside, flavanomarein, quercetagetin-7-O-glucoside, okanin 4'-O-glucoside, okanin, and chlorogenic acid, in different parts and origins of Coreopsis tinctoria and its related species. Effects of acidity, running-buffer concentration, and modifier concentration were investigated to determine the optimum conditions for analyte determination. Analysis was performed within 18 min by using 50 mM borax buffer containing 15% acetonitrile as a modifier (pH 9.0) at 25 kV and 25°C. Hyperoside was used as internal standard for quantification. The method was accurate, simple, and repeatable, and was successfully applied to the analysis in 13 samples with satisfactory assay results. Results showed that C. tinctoria obviously differed from the related flower tea materials, "Hangju" and "Gongju". The parts (flowers, buds, seeds, stems, and leaves) of C. tinctoria also varied among one another. This study can serve as a foundation for the quality control and pharmacological evaluation of different parts of C. tinctoria and its related species.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 171012
[Lr] Last revision date:171012
[St] Status:In-Process
[do] DOI:10.1002/elps.201700129

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[PMID]: 28374625
[Au] Autor:Yan RJ; Li MY; Zhou HF; Kong DY; Wu T
[Ad] Address:a State Key Laboratory of New Drug & Pharmaceutical Process , Shanghai Institute of Pharmaceutical Industry , Shanghai 200040 , China.
[Ti] Title:Two new biflavonones from Coreopsis tinctoria.
[So] Source:J Asian Nat Prod Res;19(10):960-965, 2017 Oct.
[Is] ISSN:1477-2213
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Two new biflavonone compounds, sikokianin D (1) and sikokianin E (2), were isolated from the capitulum of Coreopsis tinctoria. The structures of these compounds were elucidated by spectroscopic techniques including NMR, HRESIMS and circular dichroism (CD).
[Mh] MeSH terms primary: Biflavonoids/isolation & purification
Coreopsis/chemistry
Drugs, Chinese Herbal/isolation & purification
[Mh] MeSH terms secundary: Biflavonoids/chemistry
Chromatography, High Pressure Liquid
Drugs, Chinese Herbal/chemistry
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Biflavonoids); 0 (Drugs, Chinese Herbal); 0 (sikokianin D); 0 (sikokianin E)
[Em] Entry month:1710
[Cu] Class update date: 171003
[Lr] Last revision date:171003
[Js] Journal subset:IM
[Da] Date of entry for processing:170404
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2017.1307833

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[PMID]: 28959851
[Au] Autor:Ma XL; Ma LN; Mao XM; Zhang YJ; Lan Y
[Ad] Address:Center Laboratory of Xinjiang Medical University, Urumqi 830011, China.
[Ti] Title:[Changes in amino acid profiling in spontaneously hypertensive rats and regulatory effect of extract from Coreopsis tinctoria].
[So] Source:Zhongguo Zhong Yao Za Zhi;42(4):772-776, 2017 Feb.
[Is] ISSN:1001-5302
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:To compare the amino acid metabolic profiling in urine of spontaneously hypertensive rats (SHR) and normal Wistar rats, and investigate the regulatory effect of extract from Coreopsis tinctoria on blood pressure and amino acid metabolic profiling in SHR. Right aged SHR and Wistar rats were housed to fit the new environment for 2 weeks. After that, their systolic pressure(SBP), diastolic pressure(DBP) were measured and urine was collected. Amino acids profiles for SHR and Wistar rats were acquired by using AQC precolumn derivatization HPLC-fluorescence method, and then partial least squares discriminant analysis(PLS-DA) was applied to facilitate differentiation and determine metabolic differences between collected samples from two groups of rats. Consequently, 40 SHR were randomly divided into 5 groups: model group, high, middle, low dosage groups of C. tinctoria extract (3.2, 1.6,0.8 g•kg⁻¹), and captopril group (4 mg•kg⁻¹). They were treated for 4 weeks by ig administration, and then their urine samples were collected to determine the amino acid metabolic profiling in various groups. After treatment for 4 weeks, as compared with Wistar group, serine, alanine, tyrosine, and cystine in the amino acid metabolic profiling were significantly increased in SHR group. As compared with SHR model group, threonine and methionine were decreased significantly in captopril group (P<0.01); amino acid metabolism was changed to different degrees in high, middle, and low dosage groups of C. tinctoria extract, and the threonine in low dose group was significantly decreased (P<0.01); serine and threonine were decreased (P<0.05), and valine, methionine and lysine were significantly decreased (P<0.01) in middle dose group; threonine, valine, methionine and lysine were significantly decreased in large dose group (P<0.01). The results showed that middle and high doses of extract from C. tinctoria could significantly improve disturbance of amino acid metabolism, help to further clarify the drug property research of C. tinctoria, and provide data support for amino acid metabolic pathway abnormalities in hypertension patients.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170929
[Lr] Last revision date:170929
[St] Status:In-Process
[do] DOI:10.19540/j.cnki.cjcmm.20170103.033

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[PMID]: 28856532
[Au] Autor:Luo R; Yao X; Liu X; Zhang Y; Ying X
[Ad] Address:School of Information Science and Technology, Shihezi University, Shihezi, 832000, Xinjiang, People's Republic of China.
[Ti] Title:Evaluation of the Nitric Oxide and Nitrite Scavenging Capability, N-Nitrosamine Formation Inhibitory Activity, and Optimization of Ultrasound-Assisted Aqueous Two-Phase System Extraction of Total Saponins from Coreopsis tinctoria Flowering Tops by Response Surface Methodology.
[So] Source:Appl Biochem Biotechnol;, 2017 Aug 30.
[Is] ISSN:1559-0291
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Coreopsis tinctoria flowering tops (CTFs) is a popular health product as herbal tea or as a traditional medicinal herb that is rich in saponins and exerts substantial biological activity. In this study, an ultrasound-assisted aqueous two-phase system (ATPS) was utilized to extract total saponins from CTFs and optimize the extraction process by response surface methodology. Moreover, the nitric oxide and nitrite scavenging capability, and N-nitrosamine formation inhibitory activity of total saponins were evaluated. Results showed that the optimal conditions for total saponins were 37.76% (w/w) ammonium sulfate and 35.62% (w/w) ethanol in ATPS coupled with ultrasonic-assisted extraction. Under the optimal conditions, the maximum yield of total saponins of 33.4 g/kg can be obtained from the CTFs raw material. The nitric oxide radical scavenging, nitrite scavenging, and N-nitrosamine inhibitory activities (SC ) were 287.92 ± 7.42, 191.63 ± 7.69, and 1787.4 ± 51.26 µg/mL, respectively. The total saponins has a certain nitric oxide and nitrite scavenging capability, and N-nitrosamine formation inhibitory activity in vitro. Given these activities, research on saponins from CTFs provides profound and lasting implications for the novel applications of C. tinctoria.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170831
[Lr] Last revision date:170831
[St] Status:Publisher
[do] DOI:10.1007/s12010-017-2574-5

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[PMID]: 28367982
[Au] Autor:Hou Y; Li G; Wang J; Pan Y; Jiao K; Du J; Chen R; Wang B; Li N
[Ad] Address:College of Life and Health Sciences, Northeastern University, Shenyang 110819, China.
[Ti] Title:Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways.
[So] Source:Sci Rep;7:45705, 2017 Apr 03.
[Is] ISSN:2045-2322
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The EtOAc extract of Coreopsis tinctoria Nutt. significantly inhibited LPS-induced nitric oxide (NO) production, as judged by the Griess reaction, and attenuated the LPS-induced elevation in iNOS, COX-2, IL-1ß, IL-6 and TNF-α mRNA levels, as determined by quantitative real-time PCR, when incubated with BV-2 microglial cells. Immunohistochemical results showed that the EtOAc extract significantly decreased the number of Iba-1-positive cells in the hippocampal region of LPS-treated mouse brains. The major effective constituent of the EtOAc extract, okanin, was further investigated. Okanin significantly suppressed LPS-induced iNOS expression and also inhibited IL-6 and TNF-α production and mRNA expression in LPS-stimulated BV-2 cells. Western blot analysis indicated that okanin suppressed LPS-induced activation of the NF-κB signaling pathway by inhibiting the phosphorylation of IκBα and decreasing the level of nuclear NF-κB p65 after LPS treatment. Immunofluorescence staining results showed that okanin inhibited the translocation of the NF-κB p65 subunit from the cytosol to the nucleus. Moreover, okanin significantly inhibited LPS-induced TLR4 expression in BV-2 cells. In summary, okanin attenuates LPS-induced activation of microglia. This effect may be associated with its capacity to inhibit the TLR4/NF-κB signaling pathways. These results suggest that okanin may have potential as a nutritional preventive strategy for neurodegenerative disorders.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1704
[Cu] Class update date: 170411
[Lr] Last revision date:170411
[St] Status:In-Data-Review
[do] DOI:10.1038/srep45705

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[PMID]: 28259154
[Au] Autor:Tsai JC; Chiu CS; Chen YC; Lee MS; Hao XY; Hsieh MT; Kao CP; Peng WH
[Ad] Address:Department of Medicinal Botanicals and Health Applications, College of Biotechnology and Bio-resources, Da-Yeh University, 168 University Rd, Dacun, Chang-Hua, Taiwan, Republic of China.
[Ti] Title:Hepatoprotective effect of Coreopsis tinctoria flowers against carbon tetrachloride-induced liver damage in mice.
[So] Source:BMC Complement Altern Med;17(1):139, 2017 Mar 04.
[Is] ISSN:1472-6882
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Coreopsis tinctoria is a traditional remedy for the management of various diseases including hepatitis. The hepatoprotective role of the plant is not scientifically explored till now. This study was designed to investigate the hepatoprotective potentials of the ethanol extract from C. tinctoria (CTEtOH) using an animal model of carbon tetrachloride (CCl )-induced acute liver injury. METHODS: CTEtOH (0.5 and 1.0 g/kg) and silymarin (200 mg/kg) were administered to the experimental mice for 7 days followed by 0.2% CCl (10 mL/kg of body weight (bw), ip), then all mice were sacrificed after 24 h. The serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were measured. Histological analysis of liver was performed. The tumor necrosis factor-α (TNF-α), interleukin-1ß (IL-1ß), interleukin-6 (IL-6), nitric oxide (NO), malondialdehyde (MDA), and antioxidant enzymatic activities were also measured.. RESULTS: The results revealed that the serum ALT and AST levels significantly decreased after treatment with CTEtOH. Moreover, histological analyses indicated that CTEtOH (0.5 and 1.0 g/kg) and silymarin reduced the extent of CCl -induced liver lesions. CTEtOH (0.5 and 1.0 g/kg) reduced the levels of malondialdehyde, nitric oxide, and proinflammatory cytokines (TNF-α and IL-1ß). Furthermore, CTEtOH (1.0 g/kg) reduced the level of IL-6. The activities of antioxidant enzymes, namely superoxide dismutase and glutathione reductase, significantly increased after treatment with CTEtOH (0.5 and 1.0 g/kg) and that of glutathione peroxidase increased after treatment with 1.0 g/kg of CTEtOH. CONCLUSIONS: These results demonstrate the hepatoprotective effect of CTEtOH against CCl -induced acute liver injury in mice, and the underlying hepatoprotective mechanisms are associated with antioxidant and antiproinflammatory activities.
[Mh] MeSH terms primary: Carbon Tetrachloride/toxicity
Chemical and Drug Induced Liver Injury/pathology
Coreopsis/chemistry
Flowers/chemistry
Liver/drug effects
Plant Extracts/pharmacology
Protective Agents/pharmacology
[Mh] MeSH terms secundary: Animals
Cytokines
Liver/pathology
Mice
Mice, Inbred ICR
Oxidoreductases/drug effects
Oxidoreductases/metabolism
Plant Extracts/chemistry
Protective Agents/chemistry
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Cytokines); 0 (Plant Extracts); 0 (Protective Agents); CL2T97X0V0 (Carbon Tetrachloride); EC 1.- (Oxidoreductases)
[Em] Entry month:1703
[Cu] Class update date: 170323
[Lr] Last revision date:170323
[Js] Journal subset:IM
[Da] Date of entry for processing:170305
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1604-8

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[PMID]: 28104231
[Au] Autor:Guo J; Wang A; Yang K; Ding H; Hu Y; Yang Y; Huang S; Xu J; Liu T; Yang H; Xin Z
[Ad] Address:Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China.
[Ti] Title:Isolation, characterization and antimicrobial activities of polyacetylene glycosides from Coreopsis tinctoria Nutt.
[So] Source:Phytochemistry;136:65-69, 2017 Apr.
[Is] ISSN:1873-3700
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Polyacetylene glycosides, (6Z, 12E)-tetradecadiene-8,10-diyne-1-ol-3(R)-O-ß-D-glucopyranoside (trivially named coreoside E) and (6Z, 12E)-tetradecadiene-8,10-diyne-1-ol-3(R)-O-ß-L-arabinopyranosyl-(1 â†’ 2)-ß-D-glucopyranoside (trivially named coreoside F), were isolated from buds of Coreopsis tinctoria Nutt., together with one known compound, coreoside B. Their chemical structures were elucidated by extensive spectroscopic analysis and on the basis of their chemical reactivities. Coreoside E exhibited high levels of antimicrobial activity against Staphylococcus aureus and Bacillus anthracis with minimum inhibitory concentrations of 27 ± 0.27 and 18 ± 0.40 µM, respectively, whereas coreoside F and coreoside B showed weak antimicrobial activity against S. aureus and B. anthracis.
[Mh] MeSH terms primary: Anti-Infective Agents/isolation & purification
Anti-Infective Agents/pharmacology
Coreopsis/chemistry
Glycosides/isolation & purification
Glycosides/pharmacology
Polyacetylenes/isolation & purification
Polyacetylenes/pharmacology
[Mh] MeSH terms secundary: Anti-Infective Agents/chemistry
Bacillus anthracis/drug effects
Glucosides
Glycosides/chemistry
Microbial Sensitivity Tests
Molecular Structure
Polyacetylenes/chemistry
Staphylococcus aureus/drug effects
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Infective Agents); 0 (Glucosides); 0 (Glycosides); 0 (coreoside E); 0 (coreoside F); 25067-58-7 (Polyacetylenes)
[Em] Entry month:1703
[Cu] Class update date: 170321
[Lr] Last revision date:170321
[Js] Journal subset:IM
[Da] Date of entry for processing:170120
[St] Status:MEDLINE

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[PMID]: 27803790
[Au] Autor:Zhang Y; Yuan C; Fang H; Li J; Su S; Chen W
[Ad] Address:Ministry of Education, Pharmacy Shihezi University Xinjiang China.
[Ti] Title:Total flavonoid extract from Nutt. protects rats against myocardial ischemia/reperfusion injury.
[So] Source:Iran J Basic Med Sci;19(9):1016-1023, 2016 Sep.
[Is] ISSN:2008-3866
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:OBJECTIVES: This study aimed to evaluate the protective effects of total flavonoid extract from Coreopsis tinctoria Nutt. (CTF) against myocardial ischemia/reperfusion injury (MIRI) using an isolated Langendorff rat heart model. MATERIALS AND METHODS: Left ventricular developed pressure (LVDP) and the maximum rate of rise and fall of LV pressure (±dp/dtmax) were recorded. Cardiac injury was assessed by analyzing lactate dehydrogenase (LDH) and creatine kinase (CK) released in the coronary effluent. Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) levels were determined. Myocardial inflammation was assessed by monitoring tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), interleukin-8 (IL-8), and interleukin-6 (IL-6) levels. Myocardial infarct size was estimated. Cell morphology was assessed by 2,3,5-triphenyltetrazolium chloride and hematoxylin and eosin (HE) staining. Cardiomyocyte apoptosis was determined by terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) staining. RESULTS: Pretreatment with CTF significantly increased the heart rate and increased LVDP, as well as SOD and GSH-Px levels. In addition, CTF pretreatment decreased the TUNEL-positive cell ratio, infarct size, and levels of CK, LDH, MDA, TNF-α, CRP, IL-6, and IL-8. CONCLUSION: These results suggest that CTF exerts cardio-protective effects against MIRI via anti-oxidant, anti-inflammatory, and anti-apoptotic activities.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1611
[Cu] Class update date: 161104
[Lr] Last revision date:161104
[St] Status:In-Data-Review

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[PMID]: 27722437
[Au] Autor:Molitor C; Bijelic A; Rompel A
[Ad] Address:Universität Wien, Fakultät für Chemie, Institut für Biophysikalische Chemie, Althanstraße 14, 1090 Wien, Austria. annette.rompel@univie.ac.at.
[Ti] Title:In situ formation of the first proteinogenically functionalized [TeW O O (Glu)] structure reveals unprecedented chemical and geometrical features of the Anderson-type cluster.
[So] Source:Chem Commun (Camb);52(83):12286-12289, 2016 Oct 11.
[Is] ISSN:1364-548X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The chemistry of polyoxometalates (POMs) in a protein environment is an almost unexplored but highly relevant research field as important biological and pharmacological attributes of certain POMs are based on their interactions with proteins. We report on the A-type Anderson-Evans polyoxotungstate, [TeW O ] (TEW), mediated crystallization of Coreopsis grandiflora aurone synthase (cgAUS1) using ∼0.24 mM protein and 1.0 mM TEW. The 1.78 Å crystal structure reveals the covalent binding of TEW to the protein under the formation of an unprecedented polyoxotungstate cluster, [TeW O O (Glu)] (GluTEW). The polyoxotungstate-protein complex exhibits the first covalent bond between a protein and the A-type Anderson-Evans cluster, an archetype where up to now no hybrid structures exist. The polyoxotungstate is modified at two of its six addenda tungsten atoms, which covalently bind to the carboxylic oxygen atoms of glutamic acid (Glu157), leading to W-O distances of ∼2.35 Å. This ligand substitution reaction is accompanied by a reduction of the coordination number of two µ polyoxotungstate oxygen atoms. This is so far unique since all known hybridizations of the Anderson-Evans POM with organic units have been obtained via the functionalization of the B-type Anderson-Evans structure through its bridging oxygen atoms. The structure reported here proves the reactivity of this POM archetype's addenda atoms as it has been administered into the protein solution as a pre-assembled cluster. Moreover, the novel cluster [TeW O O (Glu)] displays the great versatility of the Anderson-Evans POM class.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161102
[Lr] Last revision date:161102
[St] Status:In-Data-Review


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