Database : MEDLINE
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[PMID]: 29425683
[Au] Autor:Li XY; Zhou LF; Gao LJ; Wei Y; Xu SF; Chen FY; Huang WJ; Tan WF; Ye YP
[Ad] Address:Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou, 310013, China.
[Ti] Title:Cynanbungeigenin C and D, a pair of novel epimers from Cynanchum bungei, suppress hedgehog pathway-dependent medulloblastoma by blocking signaling at the level of Gli.
[So] Source:Cancer Lett;420:195-207, 2018 Apr 28.
[Is] ISSN:1872-7980
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:Uncontrolled excessive activation of Hedgehog (Hh) signaling pathway is linked to a number of human malignant tumorigenesis. To obtain valuable Hh pathway inhibitors from natural product, in present study, a pair of novel epimers, Cynanbungeigenin C (CBC) and D (CBD) from the plant Cynanchum bungei Decne were chemically characterized by multiple spectroscopic data and chemical derivatization, and evaluated for their inhibition on Hh pathway. Mechanistically, CBC and CBD block Hh pathway signaling not through targeting Smo and Sufu, but at the level of Gli. In addition, both eipmers significantly suppress Hh pathway-dependent Ptch ; p53 medulloblastoma in vitro and in vivo. Furthermore, both CBC and CBD inhibited two Smo mutants induced Hh pathway activation, which suggested that they are potential compounds for the treatment of medulloblastoma with primary or acquired resistance to current Smo inhibitors. These results highlight the potential of CBC and CBD as effective lead compounds in the treatment of medulloblastoma and other Hh-dependent malignancy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:In-Data-Review

  2 / 324 MEDLINE  
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[PMID]: 29480065
[Au] Autor:Jiang HW; Gu SS; Cao L; Jiang SS; Lin J; Chen Y; Wang L; Jiao H; Li JY; Zhao WM; Li JL
[Ad] Address:a Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development , East China Normal University , Shanghai , People's Republic of China.
[Ti] Title:Potential hypoglycemic effect of acetophenones from the root bark of Cynanchum wilfordii.
[So] Source:Nat Prod Res;:1-8, 2018 Feb 25.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Three new acetophenones, named cynwilforones A-C (1-3), together with cynandione A (4) were isolated from the root bark of Cynanchum wilfordii (Maxim.) Hemsl. Their structures were deduced based on spectroscopic analysis and chemical methods. Compounds 1 and 4 exhibited potential hypoglycemic effects through inhibition of hepatic gluconeogenesis by down-regulating the expression of phosphoenolpyruvate carboxykinase and glucose-6-phosphatase. This is the first report that acetophenones from the root bark of C. wilfordii possesses potential hypoglycemic activity in vitro.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[St] Status:Publisher
[do] DOI:10.1080/14786419.2018.1443100

  3 / 324 MEDLINE  
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[PMID]: 29257324
[Au] Autor:Lee H; Kim MH; Choi YY; Hong J; Yang WM
[Ad] Address:Department of Convergence Korean Medical Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
[Ti] Title:Effects of Cynanchum wilfordii on osteoporosis with inhibition of bone resorption and induction of bone formation.
[So] Source:Mol Med Rep;17(3):3758-3762, 2018 Mar.
[Is] ISSN:1791-3004
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:Cynanchum wilfordii Hemsley has been used for the treatment of musculoskeletal diseases in traditional Republic of Korean medicine. The present study investigated the effects of C. wilfordii water extract (CW) on postmenopausal osteoporosis. Female mice were used and randomly assigned into a normal group and three ovariectomized (OVX) groups: OVX with vehicle (OVX + vehicle); OVX with 17ß­estradiol (E2; 10 µg/kg/day); and OVX with CW (1 mg/kg/day). Oral administration of CW or E2 intraperitoneal injection began 9 weeks after OVX and continued for 3 weeks. Following sacrifice, bone histology, bone mineral density (BMD) and bone mineral content (BMC) of the femur were observed. Serum osteocalcin concentration was analyzed. In addition, the expression levels of osteoprotegerin (OPG) and osterix were evaluated in human osteoblast­like Saos­2 cells. In the lateral and medial epicondyles of the CW­administrated group, dense and well­formed bone marrow cells with reduced bone marrow pores were observed. CW decreased the number of tartrate resistant acid phosphatase­positive multinucleated osteoclasts. BMD and BMC were increased following increased serum osteocalcin levels by CW treatment. The expression levels of OPG and osterix were upregulated by CW treatment in vitro. The results suggested that C. wilfordii has an advantageous effect on osteoporosis and possesses the potential to be used in osteoporosis treatment.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[St] Status:In-Process
[do] DOI:10.3892/mmr.2017.8309

  4 / 324 MEDLINE  
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[PMID]: 29430752
[Au] Autor:Ham WS; Kim J; Park DJ; Ryu HC; Jang YP
[Ad] Address:Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.
[Ti] Title:Discrimination of Cynanchum wilfordii and Cynanchum auriculatum by terahertz spectroscopic analysis.
[So] Source:Phytochem Anal;, 2018 Feb 12.
[Is] ISSN:1099-1565
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Precise identification of botanical origin of plant species is crucial for the quality control of herbal medicine. In Korea, the root part of Cynanchum auriculatum has been misused for C. wilfordii in the herbal drug market due to their morphological similarities. Currently, DNA analysis using the polymerase chain reaction (PCR) method is employed to discriminate between these species. OBJECTIVE: In order to develop a new analytical tool for the rapid discrimination of C. wilfordii and C. auriculatum, terahertz (THz) spectroscopy was employed. METHODOLOGY: Authentic samples of C. wilfordii and C. auriculatum were provided from the National Institute and standardized pellets for each species were prepared to get optimum results with terahertz time-domain spectroscopy (THz-TDS) in frequency range 0.2-1.20 THz. RESULTS: The C. wilfordii pellet showed longer time delay compare to the sample of C. auriculatum and this was due to the difference in permittivity. The pellet samples of C. wilfordii and C. auriculatum showed a permittivity difference of about 0.08 at 0.2-1.20 THz. CONCLUSION: The experimental results indicated that THz-TDS analysis can be an effective and rapid method for the discrimination of C. wilfordii and C. auriculatum, and this application can be expanded for the discrimination of other similar herbal medicines.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180212
[Lr] Last revision date:180212
[St] Status:Publisher
[do] DOI:10.1002/pca.2751

  5 / 324 MEDLINE  
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[PMID]: 29428763
[Au] Autor:Luo J; Xiao C; Zhang H; Ren F; Lei X; Yang Z; Yu Z
[Ad] Address:Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, Beijing 100083, China.
[Ti] Title:Characterization and milk coagulating properties of Cynanchum otophyllum Schneid. proteases.
[So] Source:J Dairy Sci;, 2018 Feb 07.
[Is] ISSN:1525-3198
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The herbaceous plant, Cynanchum otophyllum Schneid., is widely used as a milk coagulant to make a Chinese traditional milk product, milk cake. However, the milk-clotting compounds and their mechanism remain unclear. In this study, crude proteases were extracted from the dried leaves of Cynanchum otophyllum Schneid. using citric acid-phosphate buffer and then partially purified by weak anion exchange chromatography. Two proteases, QA and QC, with molecular weights of 14 and 27 kDa, respectively, were shown to exhibit milk-clotting activity. A study of the effects of pH and temperature on the milk-clotting activity and proteolytic activity of the proteases showed that they exhibited good pH stability from pH 5.5 to 7.5 and good thermal stability at temperatures from 50 to 70°C. The QA and QC were the cysteine proteases, able to hydrolyze ß-casein and κ-casein completely, and α-casein partially. The cleavage site on κ-casein determined by Orbitrap (Thermo Fisher Scientific, San Jose, CA) analysis showed that QA and QC could cleave κ-casein at Ser132-Thr133. Overall, the results suggest that the Cynanchum otophyllum Schneid. proteases are a promising milk-clotting enzyme that could be used for manufacturing milk cake and cheese.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180211
[Lr] Last revision date:180211
[St] Status:Publisher

  6 / 324 MEDLINE  
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[PMID]: 29328438
[Au] Autor:Park KH; Kim J; Lee EH; Lee TH
[Ad] Address:Graduate School of Biotechnology and College of Life Science, Kyung Hee University, Yongin, Gyeonggi 446­701, Republic of Korea.
[Ti] Title:Cynandione A inhibits lipopolysaccharide-induced cell adhesion via suppression of the protein expression of VCAM­1 in human endothelial cells.
[So] Source:Int J Mol Med;41(3):1756-1764, 2018 Mar.
[Is] ISSN:1791-244X
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:Cynandione A (CA) is one of the most active compounds in the roots of Cynanchum wilfordii, the extracts of which have been used extensively in East Asia to treat various diseases including anti­ischemic stroke. In the present study, the anti­adherent activity of CA in lipopolysaccharide (LPS)­stimulated human umbilical vascular endothelial cells (HUVECs) was investigated. CA markedly reduced the expression of vascular adhesion molecule­1 (VCAM­1) by LPS in HUVECs. The results also demonstrated that CA significantly reduced the expression of pro­inflammatory and chemoattractant cytokines, including interleukin (IL)­1ß, IL­6, IL­8, monocyte chemoattractant protein­1 and tumor necrosis factor­α, in LPS­activated human endothelial cells. CA inhibited the phosphorylation of mitogen­activated protein kinases, including the extracellular signal­regulated kinase 1/2 and p38 kinases. It was found that CA decreased the IKK/IκB­α phosphorylation of inhibitor of nuclear factor (NF)­κB kinase/inhibitor of NF­κB­α, suppressed translocation of the NF­κB p65 subunit into the nucleus and inhibited the transcriptional activity of NF­κB. CA also decreased human monocyte cell adhesion to endothelial cells in LPS­stimulated conditions. These results demonstrated that CA inhibited the protein expression of VCAM­1 and pro­inflammatory cytokines by suppressing the transcriptional activity of NF­κB. The results also suggested that CA may be important in the development of anti­inflammatory drugs by inhibiting the expression of cell adhesion molecules.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180118
[Lr] Last revision date:180118
[St] Status:In-Process
[do] DOI:10.3892/ijmm.2018.3376

  7 / 324 MEDLINE  
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[PMID]: 29171292
[Au] Autor:Liu JC; Yu LL; Tang MX; Lu XJ; Zhao D; Wang HF; Chen G; Su GY; Pei YH
[Ad] Address:a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
[Ti] Title:Two new steroidal saponins from the roots of Cynanchum limprichtii.
[So] Source:J Asian Nat Prod Res;:1-8, 2017 Nov 24.
[Is] ISSN:1477-2213
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:As a part of our continuing research for bioactive constituents from Cynanchum limprichtii Schltr., two new C steroidal glycosides limproside A (1) and limproside B (2) were isolated from the roots of Cynanchum limprichtii. Their structures were elucidated on the basis of 1D- and 2D-NMR spectroscopic data as well as HR-ESI-MS analysis. The cytotoxicity of two compounds against two selected human cancer cell lines was assayed.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171124
[Lr] Last revision date:171124
[St] Status:Publisher
[do] DOI:10.1080/10286020.2017.1405939

  8 / 324 MEDLINE  
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[PMID]: 29154862
[Au] Autor:Qin JJ; Chen X; Lin ZM; Xu YS; Li YM; Zuo JP; Zhao WM
[Ad] Address:Department of Natural Products Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, People's Republic of China.
[Ti] Title:C -steroidal glycosides and sesquiterpenes from the roots of Cynanchum bungei and their inhibitory activities against the proliferation of B and T lymphocytes.
[So] Source:Fitoterapia;, 2017 Nov 14.
[Is] ISSN:1873-6971
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Phytochemical investigation of the roots of Cynanchum bungei Decne (Asclepiadaceae) led to the elucidation of seven C -steroidal glycosides (1-7) including three new compounds (1-3), named cynabungosides A-C, one new eudesmane-type sesquiterpene (8), named cynabungone, and one new humulane-type sesquiterpene (9), named cynabungolide. Their structures were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations of 8 and 9 were defined unequivocally by ECD analysis and X-ray crystallography, respectively. A putative biosynthetic pathway of humulane-type sesquiterpenes 9 and 10 is proposed.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171122
[Lr] Last revision date:171122
[St] Status:Publisher

  9 / 324 MEDLINE  
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[PMID]: 29113806
[Au] Autor:Hu G; Hong D; Zhang T; Duan H; Wei P; Guo X; Mu X
[Ad] Address:Department of Animal Science and Technology, Beijing Agricultural College, Beijing 102206, People's Republic of China.
[Ti] Title:Cynatratoside-C from Cynanchum atratum displays anti-inflammatory effect via suppressing TLR4 mediated NF-κB and MAPK signaling pathways in LPS-induced mastitis in mice.
[So] Source:Chem Biol Interact;, 2017 Nov 04.
[Is] ISSN:1872-7786
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:The present study was conducted to isolate anti-inflammatory compound from Cynanchum atratum and investigate the molecular mechanisms of active compound against lipopolysaccharide (LPS)-induced mastitis in mice. Bioassay-guided fractionations and isolation (via ex vivo tests) of compounds with anti-inflammatory activity were performed on roots of C. atratum yielding a pure bioactive compound: Cynatratoside-C, identified by comparing spectral data (EI-MS, H NMR and C NMR) with literature values. Ex vivo tests showed that Cynatratoside-C inhibited the expression of TLR4 and pro-inflammatory cytokine (TNF-α, IL-6 and IL-1ß) production in LPS-stimulated primary mouse mammary epithelial cells. In vivo results indicated that Cynatratoside-C markedly attenuated LPS-induced mammary histopathologic changes and mammary oxidative stress (MDA, SOD, GPx) activity. Besides, Cynatratoside-C blocked the expression of Toll-like receptor 4 (TLR4) and then suppressed the phosphorylation of nuclear transcription factor-kappa B (NF-κB) p65 and degradation inhibitor of NF-κBα (IκBα). Further study showed that Cynatratoside-C could suppress the phosphorylation of p38, extracellular signal-regulated kinase (ERK) and c-jun NH2-terminal kinase (JNK) in mitogen-activated protein kinase (MAPK) signal pathway. In conclusion, our results suggest that Cynatratoside-C played an anti-inflammatory role in LPS-induced mastitis by regulating TLR4 and the NF-κB and MAPK signaling pathways in mammary gland tissues. Cynatratoside-C may be a promising potential therapeutic reagent for the treatment of mastitis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171108
[Lr] Last revision date:171108
[St] Status:Publisher

  10 / 324 MEDLINE  
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[PMID]: 29099237
[Au] Autor:Zhao D; Tang MX; Su SS; Lu XJ; Wang YB; Chen SF; Wang HF; Chen G; Pei YH
[Ad] Address:a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
[Ti] Title:Structure determination of two new C steroidal glycosides from Cynanchum komarovii.
[So] Source:J Asian Nat Prod Res;:1-8, 2017 Nov 03.
[Is] ISSN:1477-2213
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Two new 13,14:14,15-disecopregnane-type C steroidal glycosides, namely komarosides R (1) and S (2), along with four known compounds (3-6), were obtained from the 95% ethanol extract of the whole herbs of Cynanchum komarovii Al.Iljinski (Asclepiadaceae). The structures of new compounds were elucidated on the basis of 1D, 2D NMR spectroscopic data and acid hydrolysis. Compounds 1 and 2 showed potent inhibitory activities against human leukemia cell line (HL-60) with IC values being 6.2 and 17.6 µM, respectively, compared to the positive control 5-fluorouracil (6.4 µM).
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171103
[Lr] Last revision date:171103
[St] Status:Publisher
[do] DOI:10.1080/10286020.2017.1396977


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