Database : MEDLINE
Search on : Cynara and scolymus [Words]
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[PMID]: 29469041
[Au] Autor:Rojas Á; Gallego P; Gil-Gómez A; Muñoz-Hernández R; Rojas L; Maldonado R; Gallego R; García-Valdecasas M; Del Campo JA; Bautista JD; Romero-Gómez M
[Ad] Address:Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain. Laboratorio de Investigación clínica y traslacional en enfermedades hepáticas y digestivas y CIBERehd. Instituto de Biomedicina de Sevilla (IBiS).
[Ti] Title:Natural Extracts Abolished Lipid Accumulation in Cells Harbouring non-favourable PNPLA3 genotype.
[So] Source:Ann Hepatol;17(2):242-249, 2018 Mar 01.
[Is] ISSN:1665-2681
[Cp] Country of publication:Mexico
[La] Language:eng
[Ab] Abstract:Background & aims. G-allele of PNPLA3 (rs738409) favours triglycerides accumulation and steatosis. In this study, we examined the effect of quercetin and natural extracts from mushroom and artichoke on reducing lipid accumulation in hepatic cells. MATERIAL AND METHODS: Huh7.5 cells were exposed to oleic acid (OA) and treated with quercetin and extracts to observe the lipid accumulation, the intracellular-TG concentration and the LD size. Sterol regulatory element binding proteins-1 (SREBP-1), peroxisome proliferator-activated receptor (PPARα-γ) and cholesterol acyltransferase (ACAT) gene expression levels were analysed. RESULTS: Quercetin decreased the intracellular lipids, LD size and the levels of intracellular-TG through the down-regulation of SREBP-1c, PPARγ and ACAT1 increasing PPARα. The natural-extracts suppressed OA-induced lipid accumulation and the intracellular-TG. They down-regulate the hepatic lipogenesis through SREBP-1c, besides the activation of lipolysis through the increasing of PPARα expression. CONCLUSIONS: Quercetin and the aqueous extracts decrease intracellular lipid accumulation by down-regulation of lipogenesis and up-regulation of lipolysis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:In-Data-Review
[do] DOI:10.5604/01.3001.0010.8642

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[PMID]: 29409377
[Au] Autor:Bogavac-Stanojevic N; Kotur Stevuljevic J; Cerne D; Zupan J; Marc J; Vujic Z; Crevar-Sakac M; Sopic M; Munjas J; Radenkovic M; Jelic-Ivanovic Z
[Ad] Address:a Department of Medical Biochemistry, Faculty of Pharmacy , University of Belgrade , Belgrade , Serbia.
[Ti] Title:The role of artichoke leaf tincture (Cynara scolymus) in the suppression of DNA damage and atherosclerosis in rats fed an atherogenic diet.
[So] Source:Pharm Biol;56(1):138-144, 2018 Dec.
[Is] ISSN:1744-5116
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:CONTEXT: Polyphenols and flavonoids in artichoke leaf tincture (ALT) protect cells against oxidative damage. OBJECTIVES: We examined ALT effects on deoxyribonucleic acid (DNA) damage and lipid profiles in rat plasma and gene expression in rat aorta [haemeoxygenase-1 (HO1), haemeoxygenase-2 (HO2), NADPH oxidase 4 (NOX-4), monocyte chemoattractant protein-1 (MCP-1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2)]. MATERIALS AND METHODS: Eighteen male Wistar albino rats were divided into three groups (n = 6/group): The control group (CG) was fed with standard pellet chow for 11 weeks; the AD group was fed for a similar period of time with pellet chow supplemented with 2% cholesterol, 3% sunflower oil and 1% sodium cholate. The ADA group was fed with pellet chow (for 1 week), the atherogenic diet (see above) for the following 4 weeks and then with ALT (0.1 mL/kg body weight) and atherogenic diet for 6 weeks. According to HPLC analysis, the isolated main compounds in ALT were chlorogenic acid, caffeic acid, isoquercitrin and rutin. RESULTS: Normalized HO-1 [0.11 (0.04-0.24)] and MCP-1 [0.29 (0.21-0.47)] mRNA levels and DNA scores [12.50 (4.50-36.50)] were significantly lower in the ADA group than in the AD group [0.84 (0.35-2.51)], p = 0.021 for HO-1 [0.85 (0.61-3.45)], p = 0.047 for MCP-1 and [176.5 (66.50-221.25)], p = 0.020 for DNA scores. HO-1 mRNA was lower in the ADA group than in the CG group [0.30 (0.21-0.71), p = 0.049]. CONCLUSIONS: Supplementation with ALT limited the effects of the atherogenic diet through reduced MCP-1 expression, thereby preventing oxidative damage.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180207
[Lr] Last revision date:180207
[St] Status:In-Process
[do] DOI:10.1080/13880209.2018.1434549

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[PMID]: 29250985
[Au] Autor:Erci F; Cakir-Koc R; Isildak I
[Ad] Address:a Department of Biotechnology, Faculty of Science , Necmettin Erbakan University , Meram-Konya , Turkey.
[Ti] Title:Green synthesis of silver nanoparticles using Thymbra spicata L. var. spicata (zahter) aqueous leaf extract and evaluation of their morphology-dependent antibacterial and cytotoxic activity.
[So] Source:Artif Cells Nanomed Biotechnol;:1-9, 2017 Dec 17.
[Is] ISSN:2169-141X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Silver (Ag) nanoparticles (NPs) were green synthesized at room temperature using different concentrations of the Thymbra spicata L. var. spicata (Zahter) aqueous leaf extracts for the first time. With the synthesis of AgNPs using the leaf extract of Cynara scolymus (Artichoke) and Mentha piperita (Peppermint), the biological activities of the nanoparticles synthesized using leaf extract of three economically significant plants have been studied comparatively. Nanoparticles were characterized by different spectroscopic and microscopic analysis. TEM analysis of the biosynthesized AgNPs revealed that the size and shape of the AgNPs were changed with the plant extract concentration. Biologically synthesized AgNPs from leaf extracts of the three different plants displayed significant differences in antibacterial activity against two different gram-negative and gram-positive bacteria. Also, the results from this study show the shape dependence of the antibacterial and cytotoxic activity of silver nanoparticles synthesized using T. spicata leaf extract. The nanoparticles with different shapes exhibited the strongest antibacterial and cytotoxic activity compared to mostly spherical nanoparticles. Present results clearly indicate that biological activities of silver nanoparticles were affected by nanoparticle shape and the source of the plant extract used in the synthesis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180116
[Lr] Last revision date:180116
[St] Status:Publisher
[do] DOI:10.1080/21691401.2017.1415917

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[PMID]: 29113064
[Au] Autor:Röhrig T; Pacjuk O; Hernández-Huguet S; Körner J; Scherer K; Richling E
[Ad] Address:Division of Food Chemistry and Toxicology, University of Kaiserslautern, Erwin-Schroedinger-Straße 52, 67663 Kaiserslautern, Germany. roehrig@chemie.uni-kl.de.
[Ti] Title:Inhibition of Cyclic Adenosine Monophosphate-Specific Phosphodiesterase by Various Food Plant-Derived Phytotherapeutic Agents.
[So] Source:Medicines (Basel);4(4), 2017 Nov 04.
[Is] ISSN:2305-6320
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Phosphodiesterases (PDEs) play a major role in the regulation of cyclic adenosine monophosphate (cAMP)- and cyclic guanosine monophosphate (cGMP)-mediated pathways. Their inhibitors exhibit anti-inflammatory, vasodilatory and antithrombotic effects. Therefore, consumption of foods with PDE-inhibiting potential may possess beneficial influence on the risk of cardiovascular diseases. Four plant extracts ( , , , ) with promising ingredient profiles and physiological effects were tested for their ability to inhibit cAMP-specific PDE in vitro in a radioactive assay. Strawberry tree fruit ( ) and tea ( ) extracts did not inhibit PDE markedly. Alternatively, artichoke ( ) extract had a significant inhibitory influence on PDE activity (IC = 0.9 ± 0.1 mg/mL) as well as its flavone luteolin (IC = 41 ± 10 µM) and 3,4-dicaffeoylquinic acid (IC > 1.0 mM). Additionally, the ginger ( ) extract and one of its constituents, [6]-gingerol, significantly inhibited PDE (IC = 1.7 ± 0.2 mg/mL and IC > 1.7 mM, respectively). Crude fractionation of ginger extract showed that substances responsible for PDE inhibition were in the lipoid fraction (IC = 455 ± 19 µg/mL). A PDE-inhibitory effect was shown for artichoke and ginger extract. Whether PDE inhibition in vivo can be achieved through ingestion of artichoke or ginger extracts leading to physiological effects concerning cardiovascular health should be addressed in future research.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171108
[Lr] Last revision date:171108
[St] Status:PubMed-not-MEDLINE

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[PMID]: 28960971
[Au] Autor:Martínez-Esplá A; Valero D; Martínez-Romero D; Castillo S; Giménez MJ; García-Pastor ME; Serrano M; Zapata PJ
[Ad] Address:Department of Food Technology, School of Engineering of Orihuela (EPSO) and ‡Department of Applied Biology, School of Engineering of Orihuela (EPSO), University Miguel Hernández , Carretera de Beniel, km 3.2, 03312 Orihuela, Alicante, Spain.
[Ti] Title:Preharvest Application of Methyl Jasmonate as an Elicitor Improves the Yield and Phenolic Content of Artichoke.
[So] Source:J Agric Food Chem;65(42):9247-9254, 2017 Oct 25.
[Is] ISSN:1520-5118
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The effects of methyl jasmonate (MeJa) treatment as an elicitor of artichoke plants [Cynara cardunculus var. scolymus (L.) Fiori] on the yield and quality attributes of artichokes, especially those related to individual phenolic content and antioxidant activity, at two harvest dates and along storage were analyzed in this research. Plants treated gave a higher yield of artichokes in comparison to control plants, with 0.55 kg more per plant. MeJa treatment also increased artichoke quality and phenolic content in the edible fraction at harvest and during storage at 2 °C for 28 days as a result of the accumulation of hydroxycinnamic acids and luteolin derivatives. In addition, antioxidant activity was enhanced by MeJa treatment and correlated with the total phenolic content. Results suggest that MeJa foliar application could be a simple and practical tool to improve the yield and phytochemical content on artichokes, with elicitation being a cheap and environmentally friendly procedure to improve the health-beneficial effects of artichoke consumption.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171025
[Lr] Last revision date:171025
[St] Status:In-Process
[do] DOI:10.1021/acs.jafc.7b03447

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[PMID]: 28873750
[Au] Autor:Maietta M; Colombo R; Lavecchia R; Sorrenti M; Zuorro A; Papetti A
[Ad] Address:Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
[Ti] Title:Artichoke (Cynara cardunculus L. var. scolymus) waste as a natural source of carbonyl trapping and antiglycative agents.
[So] Source:Food Res Int;100(Pt 1):780-790, 2017 Oct.
[Is] ISSN:1873-7145
[Cp] Country of publication:Canada
[La] Language:eng
[Ab] Abstract:The role of polyphenolic compounds extractable from artichoke solid wastes in the formation of advanced glycation end products (AGEs) was studied. Outer bracts and stems were extracted using different water-ethanol mixtures and HPLC-DAD analyses indicated aqueous and hydro-alcoholic 20:80 stem extracts as the richest in polyphenols. The samples were characterized in their phenolic composition (using mass spectrometry) and antioxidant capacity. Antiglycative capacity was evaluated by in vitro BSA-sugars (glucose, fructose, and ribose) and BSA-methylglyoxal (MGO) tests, formation of Amadori products assay, direct glyoxal (GO) and MGO trapping capacity. Results indicated both extracts as effective inhibitors of fructosamine formation and antiglycative agents. In particular, aqueous extract showed the best activity in the systems containing glucose and fructose, differently from ethanolic extract, that was demonstrated able to better inhibit AGEs formation when ribose or MGO act as precursors. Ethanolic extract was also shown to be able to trap MGO and GO, with efficiency increasing after 24hours of incubation time. These activities are partially correlated with the antioxidant effect of the extract, as demonstrated by the scavenger capacity against ABTS cation and DPPH stable radicals; this relationship is evident when the model system, containing protein incubated with ribose or MGO, is considered. The different activities of the tested extracts could probably be ascribed to the different composition in chlorogenic acids (CQAs), being aqueous extract richer in 1-CQA, 3-CQA, and 1,3-di-CQA, and ethanolic extract in 5-CQA, caffeic acid, 1,5-di-CQA. These findings support further investigations to study the stability of the different CQAs in simil-physiological conditions and the feasibility of artichoke waste as antiglycative agents in food or pharmacological preparations. CHEMICAL COMPOUNDS: 5-caffeoylquinic acid (PubChem CID 5280633); 3-caffeoylquinic acid (PubChem CID 1794427); 1-caffeoylquinic acid (PubChem CID 10155076); 1,3-di-caffeoylquinic acid (PubChem CID 24720973); 1,5 - di-caffeoylquinic acid (PubChem CID 122685); caffeic acid (PubChem CID 689043); apigenin-7-glucuronide (PubChem CID 5319484); methylglyoxal PubChem CID (880); aminoguanidine hydrochloride (PubChem CID 2734687).
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170906
[Lr] Last revision date:170906
[St] Status:In-Data-Review

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[PMID]: 28722756
[Au] Autor:Spanu E; Deligios PA; Azara E; Delogu G; Ledda L
[Ad] Address:Dipartimento di Agraria, Sezione di Agronomia, Coltivazioni erbacee e Genetica, Università di Sassari, Sassari, Italy.
[Ti] Title:Effects of alternative cropping systems on globe artichoke qualitative traits.
[So] Source:J Sci Food Agric;, 2017 Jul 19.
[Is] ISSN:1097-0010
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Traditionally, globe artichoke cultivation in the Mediterranean basin is based on monoculture and on use of high amounts of nitrogen fertiliser. This raises issues regarding its compatibility with sustainable agriculture. We studied the effect of one typical conventional (CONV) and two alternative cropping systems [globe artichoke in sequence with French bean (NCV1), or in biannual rotation (NCV2) with cauliflower and with a leguminous cover crop in inter-row spaces] on yield, polyphenol and mineral content of globe artichoke heads over two consecutive growing seasons. RESULTS: NCV2 showed statistical differences in terms of fresh product yield with respect to the monoculture systems. In addition, the dihydroxycinnamic acids and dicaffeoylquinic acids of non-conventional samples were one-fold significantly higher than the conventional one. All the samples reported good mineral content, although NCV2 achieved a higher Fe content than conventional throughout the two seasons. After two and three dates of sampling, the CONV samples showed the highest levels of K content. CONCLUSION: In our study, an acceptable commercial yield and quality of 'Spinoso sardo' were achieved by shifting the common conventional agronomic management to more sustainable ones, by means of an accurate choice of cover crop species and rotations introduced in the systems. © 2017 Society of Chemical Industry.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170829
[Lr] Last revision date:170829
[St] Status:Publisher
[do] DOI:10.1002/jsfa.8558

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[PMID]: 28717205
[Au] Autor:Acquadro A; Barchi L; Portis E; Mangino G; Valentino D; Mauromicale G; Lanteri S
[Ad] Address:DISAFA, Plant Genetics and Breeding, University of Torino, Torino, Italy.
[Ti] Title:Genome reconstruction in Cynara cardunculus taxa gains access to chromosome-scale DNA variation.
[So] Source:Sci Rep;7(1):5617, 2017 Jul 17.
[Is] ISSN:2045-2322
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The genome sequence of globe artichoke (Cynara cardunculus L. var. scolymus, 2n = 2x = 34) is now available for use. A survey of C. cardunculus genetic resources is essential for understanding the evolution of the species, carrying out genetic studies and for application of breeding strategies. We report on the resequencing analyses (~35×) of four globe artichoke genotypes, representative of the core varietal types, as well as a genotype of the related taxa cultivated cardoon. The genomes were reconstructed at a chromosomal scale and structurally/functionally annotated. Gene prediction indicated a similar number of genes, while distinctive variations in miRNAs and resistance gene analogues (RGAs) were detected. Overall, 23,5 M SNP/indel were discovered (range 6,34 M -14,50 M). The impact of some missense SNPs on the biological functions of genes involved in the biosynthesis of phenylpropanoid and sesquiterpene lactone secondary metabolites was predicted. The identified variants contribute to infer on globe artichoke domestication of the different varietal types, and represent key tools for dissecting the path from sequence variation to phenotype. The new genomic sequences are fully searchable through independent Jbrowse interfaces (www.artichokegenome.unito.it), which allow the analysis of collinearity and the discovery of genomic variants, thus representing a one-stop resource for C. cardunculus genomics.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170723
[Lr] Last revision date:170723
[St] Status:In-Data-Review
[do] DOI:10.1038/s41598-017-05085-7

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[PMID]: 28629341
[Au] Autor:Ben Salem M; Ben Abdallah Kolsi R; Dhouibi R; Ksouda K; Charfi S; Yaich M; Hammami S; Sahnoun Z; Zeghal KM; Jamoussi K; Affes H
[Ad] Address:Laboratory of pharmacology, Faculty of Medicine, University of Sfax, Avenue Majida Boulila, 3029, Sfax, Tunisia.
[Ti] Title:Protective effects of Cynara scolymus leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats.
[So] Source:BMC Complement Altern Med;17(1):328, 2017 Jun 19.
[Is] ISSN:1472-6882
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Diabetes mellitus (DM) is associated with hyperglycemia, inflammatory disorders and abnormal lipid profiles, currently the extracts from leaves of cynara scolymus has been discovered to treat metabolic disorders and has been stated by multitudinous scientists according to a good source of polyphenols compounds. The present study aimed to evaluate the protective effect of the ethanol leaves extract of C. scolymus in alloxan induced stress oxidant, hepatic-kidney dysfunction and histological changes in liver, kidney and pancreas of different experimental groups of rats. METHODS: We determinate the antioxidant activity by ABTS and antioxidant total capacity (TAC) of all extracts of C. scolymus leaves, the inhibition of α-amylase activity in vitro was also investigated. Forty male Wistar rats were induced to diabetes with a single dose intraperitoneal injection (i.p.) of alloxan (150 mg/kg body weight (b.w.)). Diabetic rats were orally and daily administrated of ethanol extract from C. scolymus at two doses (200-400 mg/kg, b.w) or (12 mg/kg, b.w) with anti-diabetic reference drug, Acarbose for one month. Ethanol extract of C. scolymus effect was confirmed by biochemical analysis, antioxidant activity and histological study. RESULTS: The results indicated that the ethanol extract from leaves of C. scolymus showed the highest antioxidant activity by ABTS (499.43g± 39.72 Trolox/g dry extract) and (128.75 ± 8.45 mg VC /g dry extract) for TAC and endowed the powerful inhibition in vitro of α-amylase activity with IC50=72,22 ug/uL. In vivo, the results showed that ethanol extract from the leaves of C. scolymus (200-400 mg/kg) decreased significantly (p < 0.001) the α-amylase levels in serum of diabetic rats, respectively associated with significant reduction (p < 0.001) in blood glucose rate of 42,84% and 37,91% compared to diabetic groups after 28 days of treatment, a significant lowered of plasma total cholesterol (T-Ch) by 18,11% and triglyceride (TG) by 60,47%, significantly and low-density lipoproteins (LDL-C) by 37,77%, compared to diabetic rats, moreover, the administration of ethanol extract appears to exert anti-oxidative activity demonstrated by the increase of CAT, SOD and GSH activities in liver, kidney and pancreas of diabetic rats. This positive effect of the ethanol extract from C. scolymus was confirmed by histological study. CONCLUSION: These observed strongly suggest that ethanol extract from the leaves of C. scolymus has anti-hyperglycemic properties, at least partly mediated by antioxidant and hypolipidemic effects.
[Mh] MeSH terms primary: Cynara scolymus/chemistry
Diabetes Mellitus/drug therapy
Hypoglycemic Agents/administration & dosage
Metabolic Diseases/drug therapy
Oxidative Stress/drug effects
Plant Extracts/administration & dosage
[Mh] MeSH terms secundary: Alloxan/adverse effects
Animals
Blood Glucose/metabolism
Diabetes Mellitus/enzymology
Diabetes Mellitus/metabolism
Humans
Hypoglycemic Agents/chemistry
Hypoglycemic Agents/isolation & purification
Lipoproteins, LDL/metabolism
Male
Metabolic Diseases/enzymology
Metabolic Diseases/metabolism
Plant Extracts/chemistry
Plant Extracts/isolation & purification
Plant Leaves/chemistry
Rats
Rats, Wistar
alpha-Amylases/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (Lipoproteins, LDL); 0 (Plant Extracts); 6SW5YHA5NG (Alloxan); EC 3.2.1.1 (alpha-Amylases)
[Em] Entry month:1708
[Cu] Class update date: 170821
[Lr] Last revision date:170821
[Js] Journal subset:IM
[Da] Date of entry for processing:170621
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1835-8

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[PMID]: 28552793
[Au] Autor:Sharaf El-Deen SA; Brakat RM; Mohamed ASED
[Ad] Address:Parasitology Department, Faculty of Medicine Menoufia University, Egypt. Electronic address: drsharaf81@yahoo.com.
[Ti] Title:Artichoke leaf extract protects liver of Schistosoma mansoni infected mice through modulation of hepatic stellate cells recruitment.
[So] Source:Exp Parasitol;178:51-59, 2017 Jul.
[Is] ISSN:1090-2449
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Schistosomiasis is the second most common human parasitic disease worldwide. It is responsible for 300000 deaths per year. Liver fibrosis is the main pathology of schistosomiasis and its complications are the major cause of death in infected cases. Unfortunately, the therapeutic dose of praziquantel (PZQ) - the main drug treatment - doesn't markedly affect fibrosis. In the present study, antiparasitic and hepatoprotective properties of artichoke leaf extract (ALE) were tested on mice experimentally infected with Schistosoma mansoni (S. mansoni) and were compared to PZQ. Four mice groups were infected with S. mansoni. The first three groups received ALE, ALE + PZQ and PZQ respectively. The 4th was the positive control and the 5th was the negative control group. Worm load, egg count, granuloma numbers and diameters were measured to assess ALE anti-schistoaomal properties. Masson's trichrome staining of fibrosis, immune staining of hepatic stellate cells (HSCs) and estimation of liver enzymes were done to assess its hepato-protective action. Although it had no significant effects on worm or tissue egg load and granuloma number, ALE caused significant reduction of granuloma diameter, improvement of liver functions and liver fibrosis. ALE caused statistically significant changes in HSCs distribution. It reduced granuloma size by increasing HSCs recruitment inside granuloma and limited liver fibrosis by their inhibition in the peri- and inter-granuloma liver tissue. It was concluded that despite failure of ALE to treat S. mansoni infection, it can limit liver damage caused by this parasite by modulating HSCs recruitment.
[Mh] MeSH terms primary: Anthelmintics/therapeutic use
Cynara scolymus/chemistry
Plant Extracts/therapeutic use
Schistosomiasis mansoni/drug therapy
[Mh] MeSH terms secundary: Alanine Transaminase/analysis
Animals
Anthelmintics/pharmacology
Aspartate Aminotransferases/analysis
Female
Hepatic Stellate Cells/drug effects
Hepatic Stellate Cells/parasitology
Intestines/parasitology
Liver/enzymology
Liver/parasitology
Liver/pathology
Liver Cirrhosis/parasitology
Liver Cirrhosis/pathology
Male
Mice
Mice, Inbred BALB C
Parasite Egg Count
Plant Extracts/pharmacology
Plant Leaves/chemistry
Praziquantel/pharmacology
Praziquantel/therapeutic use
Schistosomiasis mansoni/pathology
Specific Pathogen-Free Organisms
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anthelmintics); 0 (Plant Extracts); 6490C9U457 (Praziquantel); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase)
[Em] Entry month:1706
[Cu] Class update date: 170622
[Lr] Last revision date:170622
[Js] Journal subset:IM
[Da] Date of entry for processing:170530
[St] Status:MEDLINE


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