Database : MEDLINE
Search on : Dermatitis and Herpetiformis [Words]
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[PMID]: 29464845
[Au] Autor:Kurosaki Y; Suga Y; Negi O; Takamori K; Ishii N; Makino T; Shimizu T; Hashimoto T
[Ad] Address:Department of Dermatology, Juntendo University Urayasu Hospital, Chiba, Japan.
[Ti] Title:Monitoring of immunoglobulin A antibodies to epidermal and tissue transglutaminases over an 18-month period in a Japanese patient with dermatitis herpetiformis.
[So] Source:J Dermatol;, 2018 Feb 21.
[Is] ISSN:1346-8138
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1802
[Cu] Class update date: 180221
[Lr] Last revision date:180221
[St] Status:Publisher
[do] DOI:10.1111/1346-8138.14264

  2 / 2538 MEDLINE  
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[PMID]: 29328564
[Au] Autor:Stojkovic-Filipovic J; Lekic B; Milcic D; Milinkovic MV
[Ti] Title:Pemphigus herpetiformis - a case report of a rare form of pemphigus and review of the literature.
[So] Source:Vojnosanit Pregl;73(10):967-72, 2016 Oct.
[Is] ISSN:0042-8450
[Cp] Country of publication:Serbia
[La] Language:eng
[Ab] Abstract:Introduction: Pemphigus herpetiformis is the rare variant of pemphigus with characteristic clinical features, histopathological findings different from the convectional pemphigus, and immunological findings consistent with pemphigus. Case report: We presented a 65-year-old woman with initial pruritus followed by pruritic urticarial papules and plaques, some with annular rings of tense vesicles on the periphery, on the trunk and extremities, with no mucous lesions. Histopathological examination demonstrated spongiosis and intraepidermal vesicles in the mid or subcorneal epidermis in some biopsy specimen, with neutrophil and eosinophil infiltrate. Direct immunoflorescent microscopy revealed intercellular IgG deposition, most prominent in the upper layers of epidermis. Indirect immunoflorescent microscopy showed intercellular binding of IgG autoantibodies in the patient's sera. Initially the patient was threated with systemic corticosteroids and azathioprine, but dapson provided complete clinical remission. Conclusion: This entity was established 40 years ago, and around 100 patients have been reported worldwide. It is important to be aware of this particular form of pemphigus because clinical presentation, course of the disease and therapeutic approach are different from conventional forms of pemphigus.
[Mh] MeSH terms primary: Dermatitis Herpetiformis/pathology
Pemphigus/pathology
Skin/pathology
[Mh] MeSH terms secundary: Adrenal Cortex Hormones/therapeutic use
Aged
Autoantibodies/blood
Azathioprine/therapeutic use
Biomarkers/blood
Biopsy
Dapsone/therapeutic use
Dermatitis Herpetiformis/drug therapy
Dermatitis Herpetiformis/immunology
Female
Fluorescent Antibody Technique
Humans
Immunoglobulin G/blood
Pemphigus/drug therapy
Pemphigus/immunology
Remission Induction
Skin/drug effects
Skin/immunology
Treatment Outcome
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Adrenal Cortex Hormones); 0 (Autoantibodies); 0 (Biomarkers); 0 (Immunoglobulin G); 8W5C518302 (Dapsone); MRK240IY2L (Azathioprine)
[Em] Entry month:1802
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[Js] Journal subset:IM
[Da] Date of entry for processing:180113
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150617044S

  3 / 2538 MEDLINE  
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[PMID]: 29417981
[Au] Autor:Gornowicz-Porowska J; Seraszek-Jaros A; Bowszyc-Dmochowska M; Kaczmarek E; Dmochowski M
[Ad] Address:Autoimmune Blistering Dermatoses Section, Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland. justynagornowicz1@poczta.onet.pl.
[Ti] Title:Immunoexpression of IgA receptors (CD89, CD71) in dermatitis herpetiformis.
[So] Source:Folia Histochem Cytobiol;55(4):212-220, 2017.
[Is] ISSN:1897-5631
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:INTRODUCTION: The role of IgA receptors in dermatitis herpetiformis (DH) pathogenesis is still unknown. CD89 and CD71 may be associated with immune response during DH development. The purpose of this study was to perform semiquantitative analysis of simultaneous immunoexpression of CD89 and CD71 in DH and IgA/neutrophil-mediated non-DH dermatoses (IgAN) in relation to specific IgA autoantibodies/antibodies (tissue and epidermal transglutaminases, nonapeptides of gliadin - eTG/tTG/npG) as well neutrophil activation via the release of neutrophil elastase (NE). MATERIAL AND METHODS: In total, 48 patients were studied. The study was conducted on skin lesions and sera obtained from DH and IgAN patients. DH and IgAN served as mutually positive control groups. We used immunohistochemical technique with semiquantitative digital morphometry and ELISA to measure serum levels of anti-eTG/tTG/npG IgA. RESULTS: CD89 showed a significantly higher expression in DH than in IgAN. CD71 was overexpressed in DH and IgAN. CD89 immunoexpression correlated negatively with CD71 in IgAN. A positive correlation was revealed between CD89 immunoexpression and anti-npG IgA in DH. No statistically significant correlations were found in DH between the CD89/CD71 and NE immunoexpression, between CD71 immunoexpression and anti-tTG/eTG/npG IgA, or between CD89 immunoexpression and anti-eTG/tTG IgA serum levels. CONCLUSIONS: CD89 is probably a key IgA Fc receptor in DH development, where it is associated with immune response to gluten. CD71 may be linked with inflammation in DH and IgAN. We suggest that interaction between CD89 and CD71 can modulate the inflammation in IgAN.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180212
[Lr] Last revision date:180212
[St] Status:In-Process
[do] DOI:10.5603/FHC.a2017.0024

  4 / 2538 MEDLINE  
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[PMID]: 29301808
[Au] Autor:Vaz SO; Franco C; Santos P; Amaral R
[Ad] Address:Pediatric Department, Hospital of Divino Espírito Santo of Ponta Delgada, Ponta Delgada - São Miguel, Azores, Portugal.
[Ti] Title:Skin and coeliac disease, a lot to think about: a case series.
[So] Source:BMJ Case Rep;2018, 2018 Jan 04.
[Is] ISSN:1757-790X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Coeliac disease (CD) is an autoimmune disease, characterised by a permanent sensitivity to gluten. It is being progressively recognised as a multisystemic disease, with multiple extraintestinal manifestations. Skin conditions (eg, dermatitis herpetiformis) are an example of its manifestations; however, its underlying mechanisms are still not well understood. This article presents three cases of uncommon skin conditions in patients with a history of CD. Two of them concern linear IgA bullous dermatosis and erythema nodosum, which have been described in the literature as having potential associations with CD, though only a few cases were reported. The third case corresponds to pityriasis lichenoides-a rare lymphoproliferative disorder of unknown aetiology-, which has no correlation with CD in the literature reviewed. The authors aim to draw attention to the possibility of CD as a potential predisposing factor for the occurrence of these skin diseases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180105
[Lr] Last revision date:180105
[St] Status:In-Process

  5 / 2538 MEDLINE  
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[PMID]: 29293478
[Au] Autor:Ollague JE; Nousari CH
[Ad] Address:Dermatopathology Fellow, Department of Dermatology, Geisinger Medical Center, Danville, PA.
[Ti] Title:Expression of Elafin in Dermatitis Herpetiformis.
[So] Source:Am J Dermatopathol;40(1):1-6, 2018 Jan.
[Is] ISSN:1533-0311
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Elafin is a serine protease inhibitor that has various epithelial cell regulatory and immunomodulatory effects including inactivation of neutrophil elastases. This later role originated the interest of elafin in certain neutrophil-rich dermatoses. Interestingly, it has been speculated that elafin has a protective role by slowing the deamidation process of gliadin in celiac disease (CD), despite the typical absence of neutrophils in intestinal histologic samplings. Dermatitis herpetiformis (DH) is a chronic recurrent vesicular dermatitis associated with gluten hypersensitivity and also characterized by a neutrophilic infiltrate and granular immunoglobulin A deposits in papillary dermis. MATERIALS AND METHODS: We selected 31 formalin-fixed paraffin-embedded skin specimens of DH that demonstrated typical immunopathologic findings and probed them with rabbit polyclonal immunoglobulinG antielafin antibodies through standard immunohistochemistry analysis. Negative controls consisted of normal skin from elbow and knee surgical re-excisions specimen lacking residual tumor. Positive controls included skin biopsies of active plaque psoriasis, Sweet syndrome, and pyoderma gangrenosum. RESULTS: Similar to what has been previously reported in intestinal sampling of patients with active CD, abnormal expression of elafin was noted in virtually all probed skin biopsies of DH patients with active cutaneous disease. CONCLUSION: Under normal circumstances, keratinocytes overexpress elafin to downregulate a neutrophil mediated inflammatory response. The deficient expression of elafin in the aforementioned probed DH specimens correlates with previous similar elafin underexpression in intestinal samples of active CD. These histological findings suggest that these 2 gluten mediated disorders carry an abnormal elafin underexpression during disease activity.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180102
[Lr] Last revision date:180102
[St] Status:In-Process
[do] DOI:10.1097/DAD.0000000000000915

  6 / 2538 MEDLINE  
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[PMID]: 29267475
[Au] Autor:Faria PCP; Cruz CC; Abulafia LA; Maceira JMP; Cassia FF; Medeiros PM
[Ad] Address:Dermatology Outpatient Clinic of the Department of Dermatology of the Universidade do Estado do Rio de Janeiro (UERJ) - Rio de Janeiro (RJ), Brazil.
[Ti] Title:The importance of direct immunofluorescence in pemphigus herpetiformis diagnosis.
[So] Source:An Bras Dermatol;92(5 Suppl 1):145-147, 2017.
[Is] ISSN:1806-4841
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:Pemphigus herpetiformis is an autoimmune bullous disease, that combines clinical features of dermatitis herpetiformis and linear IgA bullous dermatosis and immunological characteristics of pemphigus, which makes this disease peculiar and this diagnosis rarely suspected in the first evaluation of the patient. The reported case is of a patient with clinically bullous disease similar to dermatitis herpetiformis, whose multiple biopsies were inconclusive, and only after direct immunofluorescence with a pemphigus pattern (intraepidermal intercellular pattern) the confirmation of the diagnosis was possible.
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1712
[Cu] Class update date: 171224
[Lr] Last revision date:171224
[St] Status:In-Process

  7 / 2538 MEDLINE  
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[PMID]: 29203970
[Au] Autor:Juczynska K; Wozniacka A; Waszczykowska E; Danilewicz M; Wagrowska-Danilewicz M; Wieczfinska J; Pawliczak R; Zebrowska A
[Ad] Address:Department of Dermatology and Venereology, Medical University of Lodz, Lodz, Poland.
[Ti] Title:Expression of the JAK/STAT Signaling Pathway in Bullous Pemphigoid and Dermatitis Herpetiformis.
[So] Source:Mediators Inflamm;2017:6716419, 2017.
[Is] ISSN:1466-1861
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:A family of eleven proteins comprises the Janus kinases (JAK) and signal transducers and activators of transcription (STAT) signaling pathway, which enables transduction of signal from cytokine receptor to the nucleus and activation of transcription of target genes. Irregular functioning of the cascade may contribute to pathogenesis of autoimmune diseases; however, there are no reports concerning autoimmune bullous diseases yet to be published. The aim of this study was to evaluate the expression of proteins constituting the JAK/STAT signaling pathway in skin lesions and perilesional area in dermatitis herpetiformis (DH) and bullous pemphigoid (BP), as well as in the control group. Skin biopsies were collected from 21 DH patients, from 20 BP patients, and from 10 healthy volunteers. The localization and expression of selected STAT and JAK proteins were examined by immunohistochemistry and immunoblotting. We found significantly higher expression of JAK/STAT proteins in skin lesions in patients with BP and DH, in comparison to perilesional skin and the control group, which may be related to proinflammatory cytokine network and induction of inflammatory infiltrate in tissues. Our findings suggest that differences in the JAK and STAT expression may be related to distinct cytokines activating them and mediating neutrophilic and/or eosinophilic infiltrate.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171220
[Lr] Last revision date:171220
[St] Status:In-Process
[do] DOI:10.1155/2017/6716419

  8 / 2538 MEDLINE  
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[PMID]: 29182792
[Au] Autor:Hietikko M; Hervonen K; Ilus T; Salmi T; Huhtala H; Laurila K; Rauhavirta T; Reunala T; Kaukinen K; Lindfors K
[Ad] Address:Coeliac Disease Research Center, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
[Ti] Title:Ex vivo Culture of Duodenal Biopsies from Patients with Dermatitis Herpetiformis Indicates that Transglutaminase 3 Antibody Production Occurs in the Gut.
[So] Source:Acta Derm Venereol;, 2017 Nov 28.
[Is] ISSN:1651-2057
[Cp] Country of publication:Sweden
[La] Language:eng
[Ab] Abstract:Coeliac disease and dermatitis herpetiformis (DH) are characterized by autoantibodies targeting transglutaminase (TG)2 and TG3, respectively. Previous studies show that TG2 antibodies are produced in the gut and can be assessed in organ culture of small-intestinal biopsies from patients with coeliac disease. Thus far, no studies have investigated TG3 antibodies in organ culture of biopsies from patients with DH, or exploited the method in DH. The aim of this study was to investigate TG3 and TG2 antibody responses in serum and small-intestinal biopsies from patients with DH with active disease, and from those in remission. The majority of patients with DH were negative for both serum and organ culture medium TG2-targeting antibodies. Surprisingly, patients with active DH secreted TG3 antibodies into the culture medium despite seronegativity. In patients secreting high levels of TG3 antibodies into the culture medium, we also detected TG3-antibody-positive cells in the small-intestinal mucosa. These findings suggest that TG3 antibodies can be investigated in the organ culture system and that their secretion occurs in the small intestine, especially in active DH.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171128
[Lr] Last revision date:171128
[St] Status:Publisher
[do] DOI:10.2340/00015555-2849

  9 / 2538 MEDLINE  
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[PMID]: 29141126
[Au] Autor:Aikoye SA; Osuagwu FC; Khalid Z; Shah B; Noveloso B; Bradley R
[Ad] Address:Department of Psychiatry, Central Michigan University College of Medicine, Saginaw, Michigan, USA.
[Ti] Title:Exacerbation of Depression Symptoms in the Presence of Dermatitis Herpetiformis Rash, Celiac Disease, and Low Cholesterol.
[So] Source:Prim Care Companion CNS Disord;19(6), 2017 Nov 09.
[Is] ISSN:2155-7780
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1711
[Cu] Class update date: 171115
[Lr] Last revision date:171115
[St] Status:In-Data-Review

  10 / 2538 MEDLINE  
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[PMID]: 29048096
[Au] Autor:Mansikka E; Salmi T; Kaukinen K; Collin P; Huhtala H; Reunala T; Hervonen K
[Ad] Address:Department of Dermatology, Tampere University Hospital, PO Box 2000, FIN-33521 Tampere, Finland.
[Ti] Title:Diagnostic Delay in Dermatitis Herpetiformis in a High-prevalence Area.
[So] Source:Acta Derm Venereol;, 2017 Oct 19.
[Is] ISSN:1651-2057
[Cp] Country of publication:Sweden
[La] Language:eng
[Ab] Abstract:Dermatitis herpetiformis (DH) is an extra-intestinal manifestation of coeliac disease. The highest currently reported prevalence of DH is in Finland, but knowledge of diagnostic delay is limited. This study investigated the duration of rash prior to diagnosis in 446 patients with DH, analysing the results in 3 periods of 15 years. The diagnosis was considered delayed when the duration of rash before diagnosis was 2 years or longer. Factors associated with delayed diagnosis were analysed. Within the 45 years, the median duration of rash before diagnosis decreased significantly, from 12.0 to 8.0 months (p = 0.002) and the occurrence of a delayed diagnosis decreased from 47% to 25% (p = 0.002). Female sex, the presence of villous atrophy, and a diagnosis of DH before the year 2000 were significantly associated with delayed diagnosis. In conclusion, the present study showed that one-quarter of patients currently have a diagnostic delay of 2 years or more, which is far from ideal.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171019
[Lr] Last revision date:171019
[St] Status:Publisher
[do] DOI:10.2340/00015555-2818


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