Database : MEDLINE
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[PMID]: 29220431
[Au] Autor:Franco ME; Bitencourt TA; Marins M; Fachin AL
[Ad] Address:Unidade de Biotecnologia, Universidade de Ribeirão Preto, Av: Costabile Romano 2201, 14096-900, Ribeirao Preto SP, Brazil.
[Ti] Title:In silico characterization of tandem repeats in Trichophyton rubrum and related dermatophytes provides new insights into their role in pathogenesis.
[So] Source:Database (Oxford);2017, 2017 Jan 01.
[Is] ISSN:1758-0463
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Database URL: http://comp.mch.ifsuldeminas.edu.br/dtrdb/.
[Mh] MeSH terms primary: Arthrodermataceae
DNA, Fungal/genetics
Databases, Genetic
Tandem Repeat Sequences/genetics
Trichophyton
[Mh] MeSH terms secundary: Animals
Arthrodermataceae/genetics
Arthrodermataceae/pathogenicity
Computer Simulation
Dermatomycoses/microbiology
Humans
Internet
Trichophyton/genetics
Trichophyton/pathogenicity
User-Computer Interface
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (DNA, Fungal)
[Em] Entry month:1801
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:171209
[St] Status:MEDLINE
[do] DOI:10.1093/database/bax035

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[PMID]: 29328472
[Au] Autor:Yuan B; Ji W; Xia H; Li J
[Ad] Address:Department of Orthopaedics, Qilu Hospital of Shandong University (Qingdao), Qingdao, Shandong 266035, P.R. China.
[Ti] Title:Combined analysis of gene expression and genome binding profiles identified potential therapeutic targets of ciclopirox in Ewing sarcoma.
[So] Source:Mol Med Rep;17(3):4291-4298, 2018 Mar.
[Is] ISSN:1791-3004
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:Ciclopirox (CPX) is a synthetic antifungal drug that is mainly used to treat dermatomycoses. The aim of the present study was to determine whether CPX could influence Ewing sarcoma progression. The present study suggested that CPX treatment may inhibit Ewing sarcoma (ES) progression through Ewing sarcoma breakpoint region 1­Friend leukemia integration 1 (EWS­FLI1), a common fusion transcript structure in patients with ES. To determine the underlying mechanisms of ES progression, cross analysis was conducted on three high­throughput genome or transcript me datasets from the Gene Expression Omnibus. The results indicated that CPX may inhibit ES growth by affecting vasculature development and DNA replication. A combination of genome­wide expression and binding profiles revealed several potential targets for CPX in ES, including collagen type I α2 chain, N­myc proto­oncogene and transforming growth factor ß1, which contained significantly enriched binding peaks of FLI1. In addition, network analysis, including a protein­protein interaction network and a transcription regulatory network, provided further detailed information about the roles of CPX in ES. This study may provide a novel solution for ES treatment and may also aid in improving its prognosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:In-Process
[do] DOI:10.3892/mmr.2018.8418

  3 / 7391 MEDLINE  
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[PMID]: 29435597
[Au] Autor:Kargl A; Kosse B; Uhrlaß S; Koch D; Krüger C; Eckert K; Nenoff P
[Ad] Address:Hautärzte am Gasteig, München, Deutschland.
[Ti] Title:Igelpilze in einer Münchner Hautarztpraxis : Fallbeschreibungen und Übersicht. [Hedgehog fungi in a dermatological office in Munich : Case reports and review].
[So] Source:Hautarzt;, 2018 Feb 12.
[Is] ISSN:1432-1173
[Cp] Country of publication:Germany
[La] Language:ger
[Ab] Abstract:Patient 1: After contact to a central European hedgehog (Erinaceus europaeus), a 50-year-old female with atopy developed erythrosquamous tinea manus on the thumb and thenar eminence of the right hand. The patient had previously been scalded by hot steam at the affected site. The zoophilic dermatophyte Trichophyton erinacei could be cultured from the hedgehog as well as from scrapings from the woman's skin. Antifungal treatment of the hedgehog was initiated using 2 weekly cycles of itraconazole solution (0.1 ml/kg body weight, BW). In addition, every other day enilconazole solution was used for topical treatment. The patient was treated with ciclopirox olamine cream and oral terbinafine 250 mg daily for 2 weeks, which led to healing of the Tinea manus .Patient 2: An 18-year-old woman presented for emergency consultation with rimmed, papulous, vesicular and erosive crusted skin lesions of the index finger, and an erythematous dry scaling round lesion on the thigh. The patient worked at an animal care facility, specifically caring for hedgehogs. One of the hedgehogs suffered from a substantial loss of spines. Fungal cultures from skin scrapings of both lesions yielded T. erinacei. Treatment with ciclopirox olamine cream and oral terbinafine 250 mg for 14 days was initiated which led to healing of the lesions. Identification of all three T. erinacei isolates from both patients and from the hedgehog was confirmed by sequencing of the internal transcribed spacer (ITS) region of the ribosomal DNA, and of the translation elongation factor (TEF)-1-alpha gene. Using ITS sequencing discrimination between T. erinacei strains from European and from African hedgehogs is possible. T. erinacei should be considered a so-called emerging pathogen. In Germany the zoophilic dermatophyte T. erinacei should be taken into account as causative agent of dermatomycoses in humans after contact to hedgehogs.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[St] Status:Publisher
[do] DOI:10.1007/s00105-018-4134-5

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[PMID]: 29420823
[Au] Autor:Schneider J; Heydel T; Klasen L; Pees M; Schrödl W; Schmidt V
[Ad] Address:Clinic for Birds and Reptiles, University of Leipzig, Leipzig, Germany.
[Ti] Title:Characterization of Nannizziopsis guarroi with genomic and proteomic analysis in three lizard species.
[So] Source:Med Mycol;, 2017 Oct 09.
[Is] ISSN:1460-2709
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Fungal infections in captive as well as in free-living reptiles caused by emerging obligate pathogenic fungi appear with increasing frequency and give occasion to establish new and fast methods for routine diagnostics. The so-called yellow fungus disease is one of the most important and common fungal dermatomycoses in central bearded dragons (Pogona vitticeps) and green iguanas (Iguana iguana) and is caused by Nannizziopsis guarroi. The aim of this study was to prove reliability in identification of N. guarroi with Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in comparison to molecular biological analysis of ribosomal DNA genes. In seven lizards from three different species, including central bearded dragons, green iguanas, and a European green lizard (Lacerta viridis), dermatomycoses caused by N. guarroi were diagnosed by isolation of the fungal pathogen as well as histopathological confirmation of the granulomatous inflammatory reaction in deep skin biopsies. With this survey, we proved that MALDI-TOF MS is a diagnostic tool for accurate identification of N. guarroi. Besides small subunit 18S rDNA (SSU) and internal transcribed spacer (ITS)1-5.8S rDNA, a large fragment of the large subunit of the 28S rDNA (LSU), including the domain (D)1 and D2 have been sequenced, for phylogenetical analysis. Large fragment of the LSU from N. guarroi has been sequenced for the first time. Yellow fungus disease in a European lizard species is described for the first time to our knowledge as well, which could be of importance for free-ranging populations of European lizards.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180208
[Lr] Last revision date:180208
[St] Status:Publisher
[do] DOI:10.1093/mmy/myx083

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[PMID]: 29417157
[Au] Autor:Buder V; Augustin M; Schäfer I; Welsch G; Catala-Lehnen P; Herberger K
[Ad] Address:Institut für Versorgungsforschung in der Dermatologie und bei Pflegeberufen (IVDP), Universitätsklinikum Hamburg-Eppendorf (UKE), Martinistr. 52, 20246, Hamburg, Deutschland. ivdp@uke.de.
[Ti] Title:Prävalenz von Dermatomykosen bei Profifußballspielern : Untersuchung im Rahmen der Bundesligatauglichkeitsuntersuchung (2013­2015) im Vergleich mit Daten der Allgemeinbevölkerung. [Prevalence of dermatomycoses in professional football players : A study based on data of German Bundesliga fitness check-ups (2013-2015) compared to data of the general population].
[So] Source:Hautarzt;, 2018 Feb 07.
[Is] ISSN:1432-1173
[Cp] Country of publication:Germany
[La] Language:ger
[Ab] Abstract:BACKGROUND: The prevention, early diagnosis and treatment of onychomycosis is of great importance for professional athletes to avoid physical limitations by complications. So far, there is only little data on the prevalence of dermatomycosis in professional athletes. OBJECTIVES: The aim of the study was to detect the prevalence of dermatomycosis in professional football players compared to the general population. MATERIALS AND METHODS: The prospective, non-interventional, controlled study on the prevalence of dermatomycosis in professional football players was carried out on football players of a German Bundesliga team compared with a previously studied, equivalently aged German working population. A questionnaire survey, a dermatological check-up and a microbiological detection of pathogens in cases of suspicion were performed. RESULTS: Data of 84 football players (n = 45 in 2013; n = 39 in 2015) were compared to data of n = 8186 male employees between 17 and 35 years of age. In the group of athletes, there were findings of 60.7% onychomycosis, 36.9% of tinea pedis and 17.8% of pityriasis versicolor. In the group of the age-equivalent general German working population the findings were: onychomycosis 3.3%, tinea pedis 3.2%, pityriasis versicolor 1.4%. CONCLUSION: Our study shows a clearly higher risk for fungal diseases of the skin especially on the feet of professional football players. The results show a necessity for elucidation within prevention and the establishment of an appropriate therapy of dermatomycosis for professional football players.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180208
[Lr] Last revision date:180208
[St] Status:Publisher
[do] DOI:10.1007/s00105-017-4120-3

  6 / 7391 MEDLINE  
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[PMID]: 29186239
[Au] Autor:Castrejón-Pérez AD; Welsh EC; Miranda I; Ocampo-Candiani J; Welsh O
[Ad] Address:Department of Dermatology, Universidad Autonoma de Nuevo Leon, School of Medicine, University Hospital Dr. Jose Eleuterio Gonzalez - Monterrey, Mexico.
[Ti] Title:Cutaneous mucormycosis.
[So] Source:An Bras Dermatol;92(3):304-311, 2017 May-Jun.
[Is] ISSN:1806-4841
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:Cutaneous mucormycosis is an emerging fungal infection caused by opportunistic fungi of the phylum Glomeromycota. It is frequent in poorly controlled diabetic patients and individuals with immunosuppression. It is usually acquired by direct inoculation through trauma. The clinical presentation is nonspecific, but an indurated plaque that rapidly evolves to necrosis is a common finding. Diagnosis should be confirmed by demonstration of the etiological agent and new molecular diagnostic tools have recently been described. It is an invasive life-threatening disease and in order to improve survival, a prompt diagnosis and multidisciplinary management should be provided. The treatment of choice is amphotericin B, but new azoles, such as posaconazole and isavuconazole, must be considered.
[Mh] MeSH terms primary: Dermatomycoses
Mucormycosis
[Mh] MeSH terms secundary: Antifungal Agents/therapeutic use
Dermatomycoses/diagnosis
Dermatomycoses/drug therapy
Dermatomycoses/epidemiology
Dermatomycoses/microbiology
Humans
Mucormycosis/diagnosis
Mucormycosis/drug therapy
Mucormycosis/epidemiology
Mucormycosis/microbiology
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Antifungal Agents)
[Em] Entry month:1801
[Cu] Class update date: 180131
[Lr] Last revision date:180131
[Js] Journal subset:IM
[Da] Date of entry for processing:171130
[St] Status:MEDLINE

  7 / 7391 MEDLINE  
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[PMID]: 29310381
[Au] Autor:Liu X; Yang J; Ma W
[Ad] Address:Department of Pulmonary Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
[Ti] Title:Primary cutaneous aspergillosis caused by Aspergillus.fumigatus in an immunocompetent patient: A case report.
[So] Source:Medicine (Baltimore);96(48):e8916, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Primary cutaneous aspergillosis in immunocompromised patients has been well described in extensive investigations. However, in immunocompetent hosts, primary cutaneous infection of aspergillus occurs rarely, and remains poorly characterized. PATIENT CONCERNS: We present a case of primary cutaneous aspergillosis manifested by erythematous plague covered with flava eschar. DIAGNOSES: The patient was diagnosed with primary cutaneous aspergillosis. INTERVENTIONS: Treatments with oral itraconazole at a dose of 75 mg/d and local wound care with ciclopirox olamine ointment were administered. OUTCOMES: After half a month, a partial resolution and a decrease in tenderness indicated gradual improvement, and a complete remission was achieved 2 months later. LESSONS: Primary cutaneous aspergillosis could occur in immunocompetent hosts. The initial lesions may appear in different forms, including macules, papules, nodules, or plaques. Repeated biopsy of a skin lesion for both culture and histopathology is needed.
[Mh] MeSH terms primary: Aspergillosis/drug therapy
Aspergillus fumigatus
Dermatomycoses/drug therapy
[Mh] MeSH terms secundary: Antifungal Agents/therapeutic use
Child
Dermatomycoses/pathology
Humans
Immunocompetence
Itraconazole/therapeutic use
Male
Pyridones/therapeutic use
Skin/drug effects
Skin/pathology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Antifungal Agents); 0 (Pyridones); 19W019ZDRJ (ciclopirox); 304NUG5GF4 (Itraconazole)
[Em] Entry month:1801
[Cu] Class update date: 180116
[Lr] Last revision date:180116
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180110
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008916

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[PMID]: 29174577
[Au] Autor:Cantelli BAM; Bitencourt TA; Komoto TT; Beleboni RO; Marins M; Fachin AL
[Ad] Address:Biotechnology Unit, Ribeirão Preto University, SP, Brazil.
[Ti] Title:Caffeic acid and licochalcone A interfere with the glyoxylate cycle of Trichophyton rubrum.
[So] Source:Biomed Pharmacother;96:1389-1394, 2017 Dec.
[Is] ISSN:1950-6007
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:Trichophyton rubrum is the most common causative agent of dermatomycoses worldwide. Despite the increasing incidence of fungal infections, the number of commercially available antifungal drugs is limited, mainly because of the biochemical similarities between fungal and mammalian cells. Biomolecules of different origins might lead to the discovery of new pharmacological targets that are more specific to the fungal cell. In this respect, caffeic acid (CA) and licochalcone A (LicoA) exhibit activity against some human pathogenic fungi by acting on important fungal molecular targets. The glyoxylate cycle is involved in the adaptation of fungal cells inside the human cell and is well established for some fungi of clinical interest. Activation of this cycle is related to the survival of fungi in nutrient-limited environments. However, little is known about the involvement of the glyoxylate cycle in this process in dermatophytes. The objective of this study was to evaluate the antifungal activity of CA and LicoA against T. rubrum, investigating specifically the effect of these compounds on important antifungal targets such as ergosterol synthesis, cell wall and glyoxylate cycle. The minimum inhibitory concentration was 86.59 µM for CA and 11.52 µM for LicoA. Plasma membrane damage and a reduction in ergosterol levels were observed after the exposure of T. rubrum to CA, but not to LicoA. Evaluation of gene expression in T. rubrum co-cultured with human keratinocytes (HaCat) in the absence of the antifungal compounds showed induction of genes related to the ergosterol biosynthesis pathway and genes encoding enzymes involved in cell wall synthesis and in the glyoxylate cycle. The same genes were significantly repressed after exposure of the co-culture to subinhibitory concentrations of CA and LicoA. The enzymatic activity of isocitrate lyase was reduced in the presence of LicoA and a moderate reduction was observed in the presence of CA. These results indicate that CA and LicoA act on targets that play important roles in pathogen-host interactions, in antifungal activity and, especially, in the glyoxylate cycle.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171219
[Lr] Last revision date:171219
[St] Status:In-Process

  9 / 7391 MEDLINE  
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[PMID]: 29067631
[Au] Autor:Uhrlaß S; Mayser P; Schwarz R; Koch D; Krüger C; Korfmann I; Nenoff P
[Ad] Address:Laboratory for Medical Microbiology, Mölbiser Hauptstraße 8, 04571, Rötha/OT Mölbis, Germany.
[Ti] Title:Dermatomycoses Due to Nannizzia praecox (Formerly Microsporum praecox) in Germany: Case Reports and Review of the Literature.
[So] Source:Mycopathologia;, 2017 Oct 24.
[Is] ISSN:1573-0832
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Nannizzia praecox, formerly known as Microsporum praecox, is a geophilic dermatophyte. Up to now 31 cases of human tinea have been reported in the literature, most of them with an inflammatory course. Three recent cases diagnosed in Germany within 1 year suggest that the fungus might be a more common cause of human dermatophytosis than reported so far. This might be based on the fact that N. praecox is often found in an equine environment and that horse riding is becoming more popular recently.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1710
[Cu] Class update date: 171025
[Lr] Last revision date:171025
[St] Status:Publisher
[do] DOI:10.1007/s11046-017-0213-x

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[PMID]: 29049207
[Au] Autor:Cheng W; Wang G; Yang M; Sun L; Dong H; Chen Y; Cheng H
[Ad] Address:Division of Nephrology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
[Ti] Title:Cutaneous mucormycosis in a patient with lupus nephritis: A case report and review of literature.
[So] Source:Medicine (Baltimore);96(42):e8211, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Mucormycosis is a rare fungal infection but life-threatening, especially in lupus nephritis (LN). Mucormycosis may manifest as rhino-orbital-cerebral, pulmonary, cutaneous, gastrointestinal, renal, or disseminated forms. PATIENT CONCERNS: We report a case of a 52-year-old woman with cutaneous mucormycosis infection who was admitted because of LN. DIAGNOSES: Histopathological analysis of the lesion confirmed the Rhizopus microspores from the family Mucoraceae. INTERVENTIONS AND OUTCOMES: The mortality of mucormycosis remains unacceptably high. Our patient died at last even with standard therapy (aggressive surgical debridement and anti-mucormycosis drugs). LESSONS: It is difficult to diagnose because lacking of specific clinical features, it is necessary to identify the susceptible patients, and then make diagnosis rapidly through tissue biopsy. Despite the outcome is poor, aggressive surgical debridement and Amphotericin B/Posaconazole can be effective.
[Mh] MeSH terms primary: Dermatomycoses/microbiology
Lupus Nephritis/microbiology
Mucormycosis/microbiology
[Mh] MeSH terms secundary: Fatal Outcome
Female
Humans
Middle Aged
Rhizopus/isolation & purification
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1710
[Cu] Class update date: 171122
[Lr] Last revision date:171122
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:171020
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008211


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