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Search on : Dictamnus [Words]
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[PMID]: 29431803
[Au] Autor:Maietta M; Colombo R; Corana F; Papetti A
[Ad] Address:Department of Drug Sciences, University of Pavia, Pavia, Italy. adele.papetti@unipv.it.
[Ti] Title:Cretan tea (Origanum dictamnus L.) as a functional beverage: an investigation on antiglycative and carbonyl trapping activities.
[So] Source:Food Funct;, 2018 Feb 12.
[Is] ISSN:2042-650X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Accumulation of advanced glycation end products (AGEs) in vivo is associated with many chronic disorders such as diabetes, renal failure, aging, and Alzheimer's disease. The aim of this study was to expand the knowledge about the functional properties of Origanum dictamnus L. beverage (Cretan tea) by an investigation about the inhibitory effects on the formation of AGEs and the capacity to trap dicarbonyl compounds. Dittany infusion was characterized for its polyphenolic composition by RP-HPLC-DAD-ESI/MS and twenty compounds were detected. Its antiglycative property was evaluated by in vitro BSA-sugar (glucose, fructose, and ribose) and BSA-methylglyoxal (MGO) assays, tests for the formation of Amadori products and dicarbonyl compounds, and the direct glyoxal (GO) and MGO trapping capacity. The infusion showed the highest inhibitory effect on the formation of dicarbonyl compounds and AGEs (activity values range from 72-100%) and only a weak effect on the formation of Amadori products, indicating that the antiglycative action occurred primarily during the last two phases of the non-enzymatic glycation reaction. These activities are partially correlated with the antioxidant/antiradical activity, as demonstrated by the scavenger capacity against the ABTS cation and DPPH stable radicals, and the reducing power. The registered high anti-AGE capacity could probably be ascribed to the dittany polyphenolic composition particularly rich in flavone derivatives. These findings support further investigations to study the feasibility of dittany as an antiglycative agent in food or cosmetic preparation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180212
[Lr] Last revision date:180212
[St] Status:Publisher
[do] DOI:10.1039/c7fo01930k

  2 / 127 MEDLINE  
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[PMID]: 28952271
[Au] Autor:Huang YX; Guo YM; Zhou YF; Zhang CE; Jing J; Liu SJ; Zhang NN; Song JY; Xiao XH; Wang JB
[Ad] Address:Chengde Medical College, Chengde 067000, China.
[Ti] Title:[Dictamni Cortex powder-induced liver injury based on integrated evidence chain].
[So] Source:Zhongguo Zhong Yao Za Zhi;42(3):600-606, 2017 Feb.
[Is] ISSN:1001-5302
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:A typical clinical case of taking Dictamni Cortex(Baixianpi) powder was analyzed to study liver damage caused by Dictamni Cortex. Liver damage was diagnosed according to the integrated evidence chain method recommended by the Guideline for Diagnosis and Treatment of Herb-Induced Liver Injury. By analyzing clinical history and biochemistry and imaging examinations, underlying diseases, such as viral hepatitis, autoimmune liver disease and alcoholic liver disease, were excluded. Through the investigation of medication history, we made it clear that the patient only took Dictamni Cortex powder during the period, and thus suspected that the liver injury was induced by Dictamni Cortex. Furthermore, the quality of the drug was tested, and the results showed it was consistent with the quality standard of Chinese Pharmacopoeia. DNA barcoding showed that the drug was 100% similar with Dictamnus dasycarpus. Moreover, exogenous harmful substances and chemical drug additions were tested, and the results showed that the content of heavy metal, pesticide residues and microbial toxin were consistent with the required standards, and no chemical drug additions were found in Agilent Fake TCM-Drugs database. In summary, we confirmed that the clinical case of drug-induced liver injury was induced by D. dasycarpus with the dose of 15 g•d⁻¹, which exceeded the prescribed amount of Chinese Pharmacopoeia. According to the Guideline for Diagnosis and Treatment of Herb-Induced Liver Injury, the case of drug-induced liver injury induced by D. dasycarpus was confirmed, which provided a direct and reliable evidence for the study of risk of liver injury induced by D. dasycarpus and its relevant preparations.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170927
[Lr] Last revision date:170927
[St] Status:In-Process
[do] DOI:10.19540/j.cnki.cjcmm.2017.0015

  3 / 127 MEDLINE  
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[PMID]: 28884830
[Au] Autor:Han X; Chen H; Zhou J; Tai H; Gong H; Wang X; Huang N; Qin J; Fang T; Wang F; Xiao H
[Ad] Address:Lab for Aging Research, Center of Gerontology and Geriatrics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China.
[Ti] Title:The inhibitory effect in Fraxinellone on oxidative stress-induced senescence correlates with AMP-activated protein kinase-dependent autophagy restoration.
[So] Source:J Cell Physiol;, 2017 Sep 08.
[Is] ISSN:1097-4652
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:As a natural metabolite of limonoids from Dictamnus dasycarpus, fraxinellone has been reported to be neuroprotective and anti-inflammatory. However, its influence on cellular metabolism remains largely unknown. In the present study, we investigated the effect of fraxinellone on cellular senescence-induced by oxidative stress and the potential mechanism. We found that fraxinellone administration caused growth arrest and certainly repressed the activity of senescence associated ß-galactosidase as well as the expression of senescence-associated-genes. Interestingly, this effect of fraxinellone is closely correlated with the restoration of impaired autophagy and the activation of AMPK. Notably, fraxinellone reacts in an AMPK-dependent but mTORC1-independent manner. Together, our study demonstrates for the first time that fraxinellone has the effect on senescence inhibition and AMPK activation, and supports the notion that autophagic mechanism is important for aging prevention. These findings expanded the list of natural compounds and will be potentially utilized for aging decay and/or AMPK activation.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1709
[Cu] Class update date: 170929
[Lr] Last revision date:170929
[St] Status:Publisher
[do] DOI:10.1002/jcp.26169

  4 / 127 MEDLINE  
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[PMID]: 28839376
[Au] Autor:Yang B; Lee HB; Kim S; Park YC; Kim K; Kim H
[Ad] Address:Division of Pharmacology, School of Korean Medicine, Pusan National University, Gyeongnam, Korea.
[Ti] Title:Decoction of Turcz. Root Bark Ameliorates Skin Lesions and Inhibits Inflammatory Reactions in Mice with Contact Dermatitis.
[So] Source:Pharmacogn Mag;13(51):483-487, 2017 Jul-Sep.
[Is] ISSN:0973-1296
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:BACKGROUND: The root bark of Turcz. (Dictamni Radicis Cortex) has been widely used to treat skin diseases in Korea, and its anti-inflammatory efficacies were recently reported. OBJECTIVE: The paper aims to investigate the inhibitory effects of decoction of Dictamni Radicis Cortex (DDRC) in mice with contact dermatitis (CD). MATERIALS AND METHODS: We investigated the effects of DDRC on skin lesion characteristics such as crust, scales, incrustation and petechiae, the erythema and melanin indexes, skin thickness, histopathologic changes, and cytokine production in 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced CD mice. RESULTS: Topical application of DDRC ameliorated crust, scales, incrustation, and induced by DNFB. In addition, DDRC lowered the erythema index significantly ( < 0.05). DDRC effectively inhibited enlargement of skin thickness ( < 0.05). Histopathologic observation showed that DDRC inhibited epidermal hyperplasia, hyperkeratosis, and spongiotic changes. Finally, DDRC decreased production levels of IFN-γ, TNF-α and IL-6 induced by repeated application of DNFB ( < 0.05). CONCLUSION: These data suggest that DDRC can be used in the treatment of inflammatory skin diseases including CD. Moreover, these results are closely related to the decreasing production of TNF-α IFN-γ and IL-6 in inflamed tissues. SUMMARY: DDRC ameliorated skin lesions such as crust, scales, incrustation and petechiae, and lowered erythema index on skin surface in CD miceDDRC inhibited enlargement of dorsal skin and prevented epidermal hyperplasia, hyperkeratosis, and spongiotic changes in inflamed tissuesDDRC reduced the levels of TNF-α, IFN-γ, and IL-6 in inflamed tissues of CD miceDDRC did not affect spleen/body weight ratio in CD mice. DDRC: decoction of Dictamni Radicis Cortex, CD: contact dermatitis, DNFB: 1-fluoro-2,4-dinitrofluorobenzene, AOO: acetone and olive oil, DEX: dexamethasone, CBA: cytometric bead array.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170828
[Lr] Last revision date:170828
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/0973-1296.211034

  5 / 127 MEDLINE  
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[PMID]: 28493524
[Au] Autor:Zhai W; Liu J; Liu Q; Wang Y; Yang D
[Ad] Address:The First Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China.
[Ti] Title:Rapid identification and global characterization of multiple constituents from the essential oil of Cortex Dictamni based on GC-MS.
[So] Source:J Sep Sci;40(12):2671-2681, 2017 Jun.
[Is] ISSN:1615-9314
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:The root of Dictamnus dasycarpus Turcz., also known as Cortex Dictamni, is a Chinese herbal medicine that has been commonly used in the treatment of inflammation, microbial infection, cancer, and other diseases in China for thousands of years. Recently, the essential oil of Cortex Dictamni has been widely studied, and a large number of volatile constituents have been discovered. However, the research of the essential oil of Cortex Dictamni in vivo remains unknown, especially the constituents absorbed into blood after oral administration. Hence, a sensitive and rapid method using gas chromatography with mass spectrometry combined with MassHunter software and the National Institute of Standards and Technology 2014 database was used to investigate the absorbed components in rat serum after oral administration of the essential oil of Cortex Dictamni. With the established method, a total of 36 compounds were screened and identified in the essential oil of Cortex Dictamni based on the mass spectrometry data and compound database. Among them, eight compounds, elemol, thymol methyl ether, ß-eudesmol, ß-cyclocostunolid, guaiazulene, trans-4-hydroxystilbene, ethyl oleate, and monoelaidin, were tentatively characterized in rat serum. This work demonstrated that the established method proved to be a powerful technique for rapid, simple, reliable, and automated identification of bioactive components of herbal medicine.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1705
[Cu] Class update date: 170622
[Lr] Last revision date:170622
[St] Status:In-Data-Review
[do] DOI:10.1002/jssc.201700072

  6 / 127 MEDLINE  
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[PMID]: 28240396
[Au] Autor:Li ZY; Zhang C; Chen L; Chen BD; Li QZ; Zhang XJ; Li WP
[Ad] Address:Department of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, 3002# Sungang Road, Futian District, Shenzhen, 518035, China.
[Ti] Title:Radicol, a Novel Trinorguaiane-Type Sesquiterpene, Induces Temozolomide-Resistant Glioma Cell Apoptosis via ER Stress and Akt/mTOR Pathway Blockade.
[So] Source:Phytother Res;31(5):729-739, 2017 May.
[Is] ISSN:1099-1573
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Glioblastoma multiforme (GBM) is the most frequent, lethal and aggressive tumour of the central nervous system (CNS) in adults. Multidrug resistance (MDR) results in undesirable prognosis during GBM chemotherapy. In this study, we determined that Radicol (RAD), a novel trinorguaiane-type sesquiterpene originally isolated from the root of Dictamnus radicis Cortex, exhibited potently cytotoxic effect on temozolomide (TMZ)-resistant GBM cell lines in a dose-dependent manner. Radicol-induced apoptosis was confirmed with Hoechst 33342/propidium iodide and terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end-labelling (TUNEL) staining. Studies investigating the mechanism revealed that RAD triggered an attenuation of protein disulphide isomerase (PDI) and induced the unmitigated unfolded protein response (UPR) and lethal endoplasmic reticulum (ER) stress. Simultaneously, we further demonstrated that RAD suppressed the activation of Akt/mTOR/p70S6K phosphorylation by up-regulating the induction of glycogen synthase kinase-3ß (GSK-3ß). These results established a link between RAD-induced ER stress and inhibition of the Akt/mTOR/p70S6K pathway, and the attenuation of PDI and activation of GSK-3ß might be the synergistic target of antineoplastic effects during RAD-induced apoptosis. These findings suggested that RAD, possessing multiple cytotoxicity targets, low molecular weight and high lipid solubility, could be a promising agent for the treatment of malignant gliomas. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] MeSH terms primary: Antineoplastic Agents/pharmacology
Dacarbazine/analogs & derivatives
Drug Resistance, Neoplasm
Glioma/pathology
Sesquiterpenes/pharmacology
[Mh] MeSH terms secundary: Animals
Apoptosis/drug effects
Cell Line, Tumor
Dacarbazine/pharmacology
Dictamnus/chemistry
Endoplasmic Reticulum Stress/drug effects
Glioblastoma/drug therapy
Glycogen Synthase Kinase 3/metabolism
Humans
In Situ Nick-End Labeling
Phosphorylation/drug effects
Phytotherapy
Proto-Oncogene Proteins c-akt/metabolism
Ribosomal Protein S6 Kinases, 70-kDa/metabolism
Sesquiterpenes/chemistry
Sesquiterpenes/classification
TOR Serine-Threonine Kinases
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antineoplastic Agents); 0 (Sesquiterpenes); 0 (radicol); 7GR28W0FJI (Dacarbazine); EC 2.7.1.1 (MTOR protein, human); EC 2.7.1.1 (TOR Serine-Threonine Kinases); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 70-kDa); EC 2.7.11.26 (Glycogen Synthase Kinase 3); YF1K15M17Y (temozolomide)
[Em] Entry month:1709
[Cu] Class update date: 170925
[Lr] Last revision date:170925
[Js] Journal subset:IM
[Da] Date of entry for processing:170228
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5793

  7 / 127 MEDLINE  
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[PMID]: 27519711
[Au] Autor:Efferth T; Schöttler U; Krishna S; Schmiedek P; Wenz F; Giordano FA
[Ad] Address:Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Staudinger Weg 5, 55128, Mainz, Germany. efferth@uni-mainz.de.
[Ti] Title:Hepatotoxicity by combination treatment of temozolomide, artesunate and Chinese herbs in a glioblastoma multiforme patient: case report review of the literature.
[So] Source:Arch Toxicol;91(4):1833-1846, 2017 Apr.
[Is] ISSN:1432-0738
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Glioblastoma multiforme (GBM) represents an aggressive tumor type with poor prognosis. The majority of GBM patients cannot be cured. There is high willingness among patients for the compassionate use of non-approved medications, which might occasionally lead to profound toxicity. A 65-year-old patient with glioblastoma multiforme (GBM) has been treated with radiochemotherapy including temozolomide (TMZ) after surgery. The treatment outcome was evaluated as stable disease with a tendency to slow tumor progression. In addition to standard medication (ondansetron, valproic acid, levetiracetam, lorazepam, clobazam), the patient took the antimalarial drug artesunate (ART) and a decoction of Chinese herbs (Coptis chinensis, Siegesbeckia orientalis, Artemisia scoparia, Dictamnus dasycarpus). In consequence, the clinical status deteriorated. Elevated liver enzymes were noted with peak values of 238 U/L (GPT/ALAT), 226 U/L (GOT/ASAT), and 347 U/L (γ-GT), respectively. After cessation of ART and Chinese herbs, the values returned back to normal and the patient felt well again. In the literature, hepatotoxicity is well documented for TMZ, but is very rare for ART. Among the Chinese herbs used, Dictamnus dasycarpus has been reported to induce liver injury. Additional medication included valproic acid and levetiracetam, which are also reported to exert hepatotoxicity. While all drugs alone may bear a minor risk for hepatotoxicity, the combination treatment might have caused increased liver enzyme activities. It can be speculated that the combination of these drugs caused liver injury. We conclude that the compassionate use of ART and Chinese herbs is not recommended during standard radiochemotherapy with TMZ for GBM.
[Mh] MeSH terms primary: Antineoplastic Combined Chemotherapy Protocols/adverse effects
Chemical and Drug Induced Liver Injury/etiology
Glioblastoma/therapy
[Mh] MeSH terms secundary: Aged
Antineoplastic Combined Chemotherapy Protocols/administration & dosage
Artemisinins/administration & dosage
Chemical and Drug Induced Liver Injury/physiopathology
Chemoradiotherapy/methods
Dacarbazine/administration & dosage
Dacarbazine/analogs & derivatives
Drugs, Chinese Herbal/administration & dosage
Female
Glioblastoma/pathology
Humans
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Artemisinins); 0 (Drugs, Chinese Herbal); 60W3249T9M (artesunate); 7GR28W0FJI (Dacarbazine); YF1K15M17Y (temozolomide)
[Em] Entry month:1709
[Cu] Class update date: 171116
[Lr] Last revision date:171116
[Js] Journal subset:IM
[Da] Date of entry for processing:160814
[St] Status:MEDLINE
[do] DOI:10.1007/s00204-016-1810-z

  8 / 127 MEDLINE  
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[PMID]: 27914532
[Au] Autor:Guo LN; Pei YH; Xie FX; Liu L; Cong H; Cui HX; Wang XL; Li WJ; Jian BY; Liu JC
[Ad] Address:School of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China.
[Ti] Title:Identification of antioxidant activity of two new aromatic ring butyrolactone derivatives from Dictamnus dasycarpus Turcz.
[So] Source:Chin J Nat Med;14(11):876-880, 2016 Nov.
[Is] ISSN:1875-5364
[Cp] Country of publication:China
[La] Language:eng
[Ab] Abstract:The present study carried out a phytochemical investigation on the root barks of Dictamnus dasycarpus Turcz, leading to the isolation and characterization of two new aromatic ring butyrolactone derivatives, dasycarpusphenol acid A (1) and dasycarpusphenol acid B (2). Their structures were elucidated by using spectroscopic techniques and HR-FAB-MS. Compounds 1 and 2 exhibited antioxidant activity, with their IC values being 28.95 and 41.76 mg·mL , respectively.
[Mh] MeSH terms primary: 4-Butyrolactone/chemistry
Antioxidants/chemistry
Dictamnus/chemistry
Plant Extracts/chemistry
[Mh] MeSH terms secundary: 4-Butyrolactone/isolation & purification
Antioxidants/isolation & purification
Molecular Structure
Plant Bark/chemistry
Plant Extracts/isolation & purification
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antioxidants); 0 (Plant Extracts); OL659KIY4X (4-Butyrolactone)
[Em] Entry month:1701
[Cu] Class update date: 170131
[Lr] Last revision date:170131
[Js] Journal subset:IM
[Da] Date of entry for processing:161205
[St] Status:MEDLINE

  9 / 127 MEDLINE  
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[PMID]: 27602787
[Au] Autor:Takis PG; Oraiopoulou ME; Konidaris C; Troganis AN
[Ad] Address:Department of Biological Applications and Technology, University of Ioannina, GR-451 10 Ioannina, Greece. ptakis@cc.uoi.gr atrogani@uoi.gr.
[Ti] Title:(1)H-NMR based metabolomics study for the detection of the human urine metabolic profile effects of Origanum dictamnus tea ingestion.
[So] Source:Food Funct;7(9):4104-15, 2016 Sep 14.
[Is] ISSN:2042-650X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:(1)H NMR spectroscopy was employed to investigate the repercussion of Origanum dictamnus tea ingestion in several volunteers' urine metabolic profiles, among them two with chronic inflammatory bowel diseases (IBD), mild IBD and Crohn's disease. Herein, we demonstrate that the concentrations of a lot of urinary metabolites such as hippurate, trimethylamine oxide (TMAO), citrate, and creatinine are altered, which prompts the intestinal microflora function/content perturbation as well as kidney function regulation by dictamnus tea. Interestingly, our preliminary results showed that a high dose of dictamnus tea intake appeared to be toxic for a person with Crohn's disease, since it caused high endogenous ethanol excretion in urine. All subjects' metabolic effects caused by the dictamnus tea appeared to be reversible, when all volunteers stopped its consumption. Finally, we highlight that individuals' metabolic phenotype is reflected in their urine biofluid before and after the dictamnus tea effect while all individuals have some common and different metabolic responses to this tea, implying that each phenotype has a quite different response to this tea consumption.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1609
[Cu] Class update date: 161219
[Lr] Last revision date:161219
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1039/c6fo00560h

  10 / 127 MEDLINE  
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[PMID]: 27601203
[Au] Autor:Sun JB; Tang BQ; Li Q; Wang B; Liang JY; Chen L
[Ad] Address:Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
[Ti] Title:Cytotoxic limonoids from the root bark of Dictamnus angustifolius.
[So] Source:Fitoterapia;115:92-95, 2016 Dec.
[Is] ISSN:1873-6971
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Three novel limonoids, dictangustone G (1), dictangustone H (2), and dictangustone I (3) were isolated from the root bark of Dictamnus angustifolius. Their structures were elucidated on the basis of detailed spectroscopic analysis including UV, IR, HRESIMS, 1D and 2D NMR spectroscopic experiments. Compounds 1-3 were evaluated for their cytotoxic activities using Hela, A549, MCF7, and LN229 cell lines.
[Mh] MeSH terms primary: Antineoplastic Agents, Phytogenic/chemistry
Dictamnus/chemistry
Limonins/chemistry
[Mh] MeSH terms secundary: Antineoplastic Agents, Phytogenic/isolation & purification
Cell Line, Tumor
Humans
Limonins/isolation & purification
Molecular Structure
Plant Bark/chemistry
Plant Roots/chemistry
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antineoplastic Agents, Phytogenic); 0 (Limonins)
[Em] Entry month:1701
[Cu] Class update date: 170131
[Lr] Last revision date:170131
[Js] Journal subset:IM
[Da] Date of entry for processing:161107
[St] Status:MEDLINE


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