Database : MEDLINE
Search on : Digestive and System and Abnormalities [Words]
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[PMID]: 29489656
[Au] Autor:Shang Q; Geng Q; Zhang X; Xu H; Guo C
[Ad] Address:Department of Pathology, Linyi People's Hospital, Linyi, Shandong province.
[Ti] Title:The impact of early enteral nutrition on pediatric patients undergoing gastrointestinal anastomosis a propensity score matching analysis.
[So] Source:Medicine (Baltimore);97(9):e0045, 2018 Mar.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:This study was conducted to assess the clinical advantages of early enteral nutrition (EEN) in pediatric patients who underwent surgery with gastrointestinal (GI) anastomosis.EEN has been associated with clinical benefits in various aspect of surgical intervention, including GI function recovery and postoperative complications reduction. Evaluable data documenting clinical advantages with EEN for pediatric patients after surgery with GI anastomosis are limited.We retrospectively reviewed the medical records of 575 pediatric patients undergoing surgical intervention with GI anastomosis. Among them, 278 cases were managed with EEN and the remaining cases were set as late enteral nutrition (LEN) group. Propensity score (PS) matching was conducted to adjust biases in patient selection. Enteral feeding related complications were evaluated with symptoms, including serum electrolyte abnormalities, abdominal distention, abdominal cramps, and diarrhea. Clinical outcomes, including GI function recovery, postoperative complications, length of hospital stay, and postoperative follow-up, were assessed according to EEN or LEN.Following PS matching, the baseline variables of the 2 groups were more comparable. There were no differences in the incidence of enteral feeding-related complications. EEN was associated with postoperative GI function recovery, including time to first defecation (3.1 ±â€Š1.4 days for EEN vs 3.8 ±â€Š1.0 days for LEN, risk ratio [RR], 0.62; 95% confidence interval [CI] 0.43-1.08, P = .042). A lower total episodes of complication, including infectious complications and major complications were noted in patients with EEN than in patients with LEN (117 [45.9%] vs 137 [53.7%]; OR, 0.73, 95% CI 0.52-1.03, P = .046). Mean postoperative length of stay in the EEN group was 7.4 ±â€Š1.8 days versus 9.2 ±â€Š1.4 days in the LEN group (P = .007). Furthermore, the incidence of adhesive small bowel obstruction was lower for patients with laxative administration compared with control, but no significant difference was attained (P = .092)EEN was safe and associated with clinical benefits, including shorten hospital stay, and reduced overall postoperative complications on pediatric patients undergoing GI anastomosis.
[Mh] MeSH terms primary: Digestive System Surgical Procedures
Enteral Nutrition
Postoperative Care
[Mh] MeSH terms secundary: Anastomosis, Surgical/adverse effects
Child, Preschool
Digestive System Surgical Procedures/adverse effects
Enteral Nutrition/adverse effects
Female
Follow-Up Studies
Humans
Intestinal Perforation/surgery
Intestines/surgery
Length of Stay
Male
Postoperative Care/adverse effects
Postoperative Complications
Propensity Score
Recurrence
Retrospective Studies
Time Factors
[Pt] Publication type:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180301
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000010045

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[PMID]: 29500673
[Au] Autor:Amateau SK; Lim CH; McDonald NM; Arain M; Ikramuddin S; Leslie DB
[Ad] Address:Interventional and Therapeutic Endoscopy, Division of Gastroenterology and Hepatology, Department of Medicine, University of Minnesota Medical Center, MMC 36-420 Delaware St SE, Minneapolis, MN, 55455, USA. amateau@umn.edu.
[Ti] Title:EUS-Guided Endoscopic Gastrointestinal Anastomosis with Lumen-Apposing Metal Stent: Feasibility, Safety, and Efficacy.
[So] Source:Obes Surg;, 2018 Mar 02.
[Is] ISSN:1708-0428
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Traditionally, restoration of normal bowel continuity after resection and bypass of a diseased or obstructed gastrointestinal tract can only be achieved through surgery, which can be technically challenging and comes with a risk of adverse events. Here, we describe our institutions' experience with endoscopic-guided gastroenterostomy or enteroenterostomy with lumen-apposing metal stent (LAMS) from March 2015 to August 2016. Ten patients had gastrogastrostomy (gastric pouch to gastric remnant) and three patients had jejunogastrostomy (Roux limb to gastric remnant) for the reversal of Roux-en-Y bariatric surgery. One patient had gastroduodenostomy (stomach to duodenal bulb) post antrectomy and one patient had jejunojejunostomy for distal obstruction following Roux-en-Y reconstruction. Technical and clinical success were achieved in all patients, save for delayed anastomotic stenosis following stent removal in one patient, with a mean follow-up of 126 days (3-318 days) with minimal complications in two patients. Endoscopic gastrointestinal anastomosis therefore may be a safe and feasible technique to re-establish continuity of the digestive system following bypass in the short-term.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180303
[Lr] Last revision date:180303
[St] Status:Publisher
[do] DOI:10.1007/s11695-018-3171-6

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[PMID]: 27770542
[Au] Autor:Shen ZQ; Gao SY; Li SX; Zhang TN; Liu CX; Lv HC; Zhang Y; Gong TT; Xu X; Ji C; Wu QJ; Li D
[Ad] Address:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
[Ti] Title:Sertraline use in the first trimester and risk of congenital anomalies: a systemic review and meta-analysis of cohort studies.
[So] Source:Br J Clin Pharmacol;83(4):909-922, 2017 04.
[Is] ISSN:1365-2125
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:AIM: To perform a meta-analysis of available cohort studies on the association between sertraline use by pregnant women in the first trimester and the findings of congenital anomalies in infants. METHODS: A comprehensive search of articles published from the index date up to 31 December 2015 investigating the aforementioned associations was conducted on PubMed and Web of Science. Mesh headings used included the terms "serotonin reuptake inhibitor," "sertraline," "congenital anomalies" and "obstetrical outcome." RESULTS: Twelve cohort studies that involved 6 468 241 pregnant women were identified. We summarized odds ratios (ORs) and 95% confidence intervals (CIs) of congenital anomalies using the random-effects model. Pregnant women who used sertraline in the first trimester had a statistically significant increased risk of infant cardiovascular-related malformations (OR = 1.36; 95% CI = 1.06-1.74; I  = 64.4%; n = 12) as well as atrial and/or ventricular septal defects (OR = 1.36, 95% CI = 1.06-1.76; I  = 62.2%; n = 8). Additionally, positive but nonsignificant associations between sertraline use and congenital anomalies of the nervous system (OR = 1.39; 95% CI = 0.83-2.32; I  = 0%; n = 5), digestive system (OR = 1.23; 95% CI = 0.76-1.98; I  = 0%; n = 5), eye, ear, face and neck (OR = 1.08; 95% CI = 0.33-3.55; I  = 32.1%; n = 3), urogenital system (OR = 1.03; 95% CI = 0.73-1.46; I  = 0%; n = 5), and musculoskeletal system (OR = 0.97; 95% CI = 0.69-1.36; I  = 0%; n = 5) were observed. CONCLUSION: This meta-analysis suggested that the use of sertraline use by pregnant women in the first trimester had an increased risk of cardiovascular-related malformations as well as atrial and/or ventricular septal defects in infants. Meanwhile, nonsignificant associations between sertraline use and other congenital anomalies were found. More cohort studies are warranted to provide detailed results of other congenital anomalies.
[Mh] MeSH terms primary: Abnormalities, Drug-Induced/etiology
Serotonin Uptake Inhibitors/administration & dosage
Sertraline/administration & dosage
[Mh] MeSH terms secundary: Abnormalities, Drug-Induced/epidemiology
Cohort Studies
Female
Humans
Infant
Pregnancy
Pregnancy Trimester, First
Risk
Serotonin Uptake Inhibitors/adverse effects
Sertraline/adverse effects
[Pt] Publication type:JOURNAL ARTICLE; META-ANALYSIS; REVIEW; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Serotonin Uptake Inhibitors); QUC7NX6WMB (Sertraline)
[Em] Entry month:1711
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[Js] Journal subset:IM
[Da] Date of entry for processing:161023
[St] Status:MEDLINE
[do] DOI:10.1111/bcp.13161

  4 / 2695 MEDLINE  
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SciELO Public Health full text

[PMID]: 28453112
[Au] Autor:Mogollón-Pastrán SC; García-Ubaque JC
[Ad] Address:Universidad Nacional de Colombia. Bogotá, Colombia. scmogollonp@unal.edu.co.
[Ti] Title:Tendencia y causas de la mortalidad infantil en municipios de frontera en Colombia, 2005-2011. [Trend and causes of infant mortality in border areas in Colombia from 2005 to 2011].
[So] Source:Rev Salud Publica (Bogota);18(5):700-713, 2016 Sep-Oct.
[Is] ISSN:0124-0064
[Cp] Country of publication:Colombia
[La] Language:spa
[Ab] Abstract:Objective: To evaluate the registered trends and main causes of Infant Mortality (IM) in border areas of Colombia between 2005 and 2011. Methodology: Ecological study in border areas, developed from the analysis of institutional information on IM and its causes, using the list of leading causes of death of infants and children by the WHO. For analysis, descriptive statistics and cluster analysis techniques were measured using Excel and the R-Project processing software. Results: IM decreased steadily in the country and border areas between 2005 and 2011.The existence of significantly higher numbers in some of the municipalities studied was evident. Municipalities with lower IM had significantly higher average scores related to congenital malformations, deformations and chromosomal abnormalities (conditions originated during the perinatal period), circulatory system diseases, digestive system diseases, and tumors and neoplasms. In contrast, municipalities with higher IM rates presented higher average scores related to endocrine, nutritional and metabolic diseases, infectious and parasitic diseases, and respiratory system diseases, many of them considered preventable. Discussion: Border areas are affected by economic, political and cultural aspects that make them risk zones and generate interest for health. Findings reveal inequalities in the IM behavior when compared to the rest of the country. Understanding the peculiarities in these municipalities is crucial for the health sector to implement strategies and to pose health services that adequately meet the needs, and, thus, achieve health equity for these populations.
[Mh] MeSH terms primary: Infant Mortality/trends
[Mh] MeSH terms secundary: Cardiovascular Diseases
Cause of Death/trends
Colombia/epidemiology
Female
Geography
Healthcare Disparities
Humans
Infant
Male
Neoplasms
Pregnancy
Respiratory Tract Diseases
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[Js] Journal subset:IM
[Da] Date of entry for processing:170429
[St] Status:MEDLINE

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[PMID]: 29174091
[Au] Autor:Vinck WJ; Van de Mierop F; Van Mieghem F; Vinck M; Becq H; Michils G
[Ad] Address:Department of Endocrinology, Sint Augustinus Hospital, Wilrijk, Belgium. Electronic address: wouter.vinck@skynet.be.
[Ti] Title:Pancreatic hemi-agenesis in MEN1: A clinical report.
[So] Source:Eur J Med Genet;, 2017 Nov 23.
[Is] ISSN:1878-0849
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:We first describe a patient with multiple endocrine neoplasia type 1 (MEN1) and dorsal pancreatic hemi-agenesis. Previously, pancreas divisum has been reported in MEN1. Recent data in mice have elucidated the molecular mechanisms of pancreatic endoderm specification. Disinhibition of hedgehog signaling appears to be important in how Gata4 and Gata6 variants cause pancreatic agenesis. Disinhibition of hedgehog signaling has also been observed in Men1 knockout pancreatic islets. Although we cannot exclude a spurious association between dorsal pancreatic hemi-agenesis and MEN1 in our patient, we argue that developmental abnormalities of the pancreas may have to be considered as possibly related to the MEN1 phenotype.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171206
[Lr] Last revision date:171206
[St] Status:Publisher

  6 / 2695 MEDLINE  
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[PMID]: 29049228
[Au] Autor:Zhang W; Sun H; Luo F
[Ad] Address:Department of Medical Ultrasonics, Qianfoshan Hospital Affiliated to Shan Dong University, Jinan, China.
[Ti] Title:The efficiency of sonography in diagnosing volvulus in neonates with suspected intestinal malrotation.
[So] Source:Medicine (Baltimore);96(42):e8287, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:This study is to prospectively evaluate the efficiency of sonography for volvulus diagnosis in neonates with clinically suspected intestinal malrotation.A total of 83 patients with suspected intestinal malrotation who underwent detailed abdominal sonography and upper gastrointestinal contrast study were included. Malrotation was characterized by inversion of the superior mesenteric artery (SMA) and superior mesenteric vein (SMV) in sonographic examination. The "whirlpool sign" of Color Doppler Sonography was recognized as a characteristic for malrotation with volvulus. The degrees of rotation of the SMV winding around SMA were also detected by sonography. Surgery was performed in patients with sonography diagnosed malrotation.A total of 39 patients were sonographically diagnosed as malrotation which was subsequently confirmed by surgery. The sensitivity and positive predictive value of the sonographic diagnosis were both 100% (39/39). The sensitivity, specificity and accuracy of "whirlpool sign" for the detection of midgut volvulus were 95.2% (20/21), 88.9% (16/18), and 92.3% (36/39), respectively. Greater degrees of rotation (equal or greater than 720°) showed higher risk (odds ratio, 5.0; P < .01) for intestinal necrosis occurrence.Sonography is more accurate in diagnosing suspected malrotation than upper gastrointestinal contrast study. Specific sonographic "whirlpool sign" related to volvulus may be used as a potential indicator for intestinal necrosis. In addition, sonography can exclude malrotation and may help the diagnosis of other diseases, such as annular pancreas and duodenal atresia.
[Mh] MeSH terms primary: Digestive System Abnormalities/diagnostic imaging
Intestinal Volvulus/diagnostic imaging
Ultrasonography, Doppler, Color/methods
[Mh] MeSH terms secundary: Digestive System Abnormalities/diagnosis
Digestive System Abnormalities/pathology
Female
Humans
Infant, Newborn
Intestinal Volvulus/diagnosis
Intestinal Volvulus/pathology
Male
Mesenteric Artery, Superior/diagnostic imaging
Mesenteric Artery, Superior/pathology
Mesenteric Veins/diagnostic imaging
Mesenteric Veins/pathology
Sensitivity and Specificity
[Pt] Publication type:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Entry month:1711
[Cu] Class update date: 171122
[Lr] Last revision date:171122
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:171020
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008287

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[PMID]: 28953685
[Au] Autor:Cao Y; Li J; Shen L; Wang J; Xia Z; Tao K; Wang G; Cai K
[Ad] Address:Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
[Ti] Title:Gastric cancer in a situs inversus totalis patient with multiple intestinal and vessel variations related to gastrectomy surgery: A case report and literature review.
[So] Source:Medicine (Baltimore);96(39):e8209, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Situs inversus totalis (SIT) is a rare congenital anomaly characterized by complete inversion of the abdominal and thoracic organs, and often involves multiple genetic mutations. The most suitable surgical technique for patients with multiple vessel and organ variations as well as SIT remains unclear. Furthermore, there has been insufficient clinical evidence that demonstrates which surgical techniques achieve the best outcomes. Finally, the standard of care has not yet been determined. We present the case of a 60-year-old man with SIT, who was diagnosed with moderately and poorly differentiated adenocarcinoma at the gastroesophageal junction. We further describe the advantage of using robotic-assisted laparoscopic surgery in patients with this anomaly. PATIENT CONCERNS: A 60-year-old man complained of pain in his upper abdomen for 3 months. Physical examination revealed an apex beat in the right fifth intercostal space, and vascular anomalies were noted on abdominal angiographic computed tomography. DIAGNOSES: Moderately and poorly differentiated adenocarcinoma at the gastroesophageal junction with SIT. INTERVENTIONS: Robot-assisted total gastrectomy with D2 lymph node dissection and hand-sewn Roux-en-Y anastomosis was performed. OUTCOMES: The postoperative course was uneventful, and the patient was discharged on the seventh postoperative day. LESSONS: Robotic surgery for gastric cancer is a safe and feasible alternative to laparoscopic surgery and it can be successfully used to treat gastric cancer in patients with SIT with multiple anatomic variations. As exemplified by our case, SIT might be accompanied by multiple anatomic variations. Detailed preoperative detailed imaging of the blood vessels and gastrointestinal tract is useful in these patients.
[Mh] MeSH terms primary: Adenocarcinoma in Situ
Esophagogastric Junction/pathology
Gastrectomy/methods
Preoperative Care/methods
Situs Inversus
Stomach Neoplasms
[Mh] MeSH terms secundary: Adenocarcinoma in Situ/pathology
Adenocarcinoma in Situ/physiopathology
Adenocarcinoma in Situ/surgery
Computed Tomography Angiography/methods
Digestive System Abnormalities/diagnosis
Humans
Laparoscopy/methods
Male
Middle Aged
Robotic Surgical Procedures/methods
Situs Inversus/diagnosis
Situs Inversus/physiopathology
Stomach Neoplasms/pathology
Stomach Neoplasms/physiopathology
Stomach Neoplasms/surgery
Treatment Outcome
Vascular Malformations/diagnosis
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171013
[Lr] Last revision date:171013
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:170928
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008209

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[PMID]: 28932959
[Au] Autor:Hussey M; Holleran G; Smith S; Sherlock M; McNamara D
[Ad] Address:Department of Gastroenterology, Adelaide and Meath Hospital, Tallaght, Dublin 24, Ireland. husseyma@tcd.ie.
[Ti] Title:The Role and Regulation of the 11 Beta-Hydroxysteroid Dehydrogenase Enzyme System in Patients with Inflammatory Bowel Disease.
[So] Source:Dig Dis Sci;62(12):3385-3390, 2017 Dec.
[Is] ISSN:1573-2568
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Glucocorticoids are known to modulate a number of immunological responses including counteracting inflammation. Within tissues expressing the glucocorticoid and mineralocorticoid receptors including the colon, glucocorticoid metabolism is regulated by the isoenzymes of 11ß-hydroxysteroid dehydrogenase (11ß-HSD). 11ß-HSD1 acts as an oxidoreductase converting inactive cortisone into active cortisol, while 11ß-HSD2 acts as a dehydrogenase converting active cortisol to inactive cortisone. Hexose-6 phosphate dehydrogenase (H6PDH) is a key regulator of 11ß-HSD1 activity via its generation of NADPH. Variations in the 11ß-HSD enzyme system in relation to levels of expression and regulation may have a role in IBD. The aim of this study was to investigate possible abnormalities of 11ß-HSD enzyme system in the colon of patients with IBD. METHODS: By using quantitative real-time PCR, we investigated the transcription levels of 11ß-HSD1 and 2 in colonic tissue from IBD patients and healthy controls undergoing a colonoscopy for disease assessment. Disease activity was recorded using clinical (Mayo Score/Harvey-Bradshaw Index), Biochemical (C-reactive protein), histological, and endoscopic parameters. In addition, transcription levels of H6PDH and the glucocorticoid receptor alpha (GR-α) as well as key pro-inflammatory cytokines (TNF-α, IL-1ß, IL-6, Rela (subunit for NF Kappa B)) were later examined among this group, and results were correlated with 11ß-HSD2 gene expression. Results and patient demographics were expressed as a mean (and SD), and differences between IBD patients and control groups were analyzed using a Student's t test or Mann-Whitney U test as appropriate, with a p value of ≤0.05 considered significant. Results were controlled for disease activity as outlined above. RESULTS: Results have demonstrated a significant downregulation in 11ß-HSD2 expression in IBD patients compared with controls (13.8 ± 17.1 au vs. 318.4 ± 521.1 au, p = 0.01), whereas levels of 11ß-HSD1 did not appear to vary across the two groups. Among IBD patients, there was a trend toward higher 11ß-HSD1 expression in inflamed tissue compared with matched non-inflamed tissue (422.1 ± 944 au vs. 102.2 ± 103.9, P = 0.09). Levels of H6PDH and the GR-α expression did not appear to vary among active inflamed IBD tissue and controls. As a result, we examined the association between pro-inflammatory cytokines and levels of 11ß-HSD2 expression. Results showed an upregulation of key pro-inflammatory cytokine mRNA expression (TNF-α, IL-1ß, IL-6) during inflammation with an associated downregulation of 11ß-HSD2 mRNA expression when compared to controls. Dysregulation in this pathway could have a potential role in IBD pathogenesis and may account for exogenous glucocorticoid resistance in IBD. Further work assessing the role of the 11ß-HSD enzyme system in steroid-resistant subjects is warranted.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171124
[Lr] Last revision date:171124
[St] Status:In-Process
[do] DOI:10.1007/s10620-017-4753-1

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[PMID]: 28854190
[Au] Autor:Al-Obaid K; Asadzadeh M; Ahmad S; Khan Z
[Ad] Address:Microbiology, Department of Medical Laboratories, Al-Amiri Hospital, Sharq, Kuwait.
[Ti] Title:Population structure and molecular genetic characterization of clinical Candida tropicalis isolates from a tertiary-care hospital in Kuwait reveal infections with unique strains.
[So] Source:PLoS One;12(8):e0182292, 2017.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Candida tropicalis is a frequently isolated yeast species causing bloodstream, urinary tract and other infections particularly in patients admitted to intensive care units (ICUs) and those requiring prolonged urinary catheterization (UC) or receiving broad-spectrum antibiotics (BSA). This study investigated clinical characteristics and genetic relatedness among C. tropicalis strains isolated from patients at Al-Amiri Hospital in Kuwait. C. tropicalis strains (n = 63) isolated from blood, genito-urinary, respiratory (RT) and digestive (GIT) tracts and wound sites from 54 patients were used. All isolates were phenotypically identified and tested against six antifungal drugs by using Vitek 2 system. Molecular identification was performed by PCR amplification of rDNA. Fingerprinting was achieved by 6-loci-based multilocus sequence typing (MLST) and data were analyzed by BioNumerics software for phylogenetic relationships. Patients mean age was >65 years and >20% patients were hospitalized in ICUs. Most patients had underlying conditions that included UC, BSA, diabetes and RT/GIT abnormalities. Most candiduria cases had UC, ureteric stent or suprapubic catheters. All isolates were identified as C. tropicalis by Vitek 2 and by species-specific PCR. Sixty-two isolates were susceptible to all tested antifungal drugs. MLST identified 59 diploid sequence types (DSTs) including 54 newly-identified DSTs. C. tropicalis isolates from multiple sites of same patient usually belonged to different DSTs. Interestingly, 56 of 57 isolates from 48 patients belonged to unique genotypes. Only six isolates from six patients belonged to three DSTs (clusters), however, C. tropicalis strains in each cluster were isolated >3 months apart. Our data show diverse origins of C. tropicalis infections in Kuwait as most isolates were unique strains. There was no obvious correlation between cluster isolates with time of isolation and/or hospital ward of their origin. This study presents the first MLST analysis of C. tropicalis isolates from Middle East and may be useful for studying genetic relationships among global C. tropicalis strains.
[Mh] MeSH terms primary: Candida tropicalis/genetics
Candidiasis/microbiology
[Mh] MeSH terms secundary: Antifungal Agents/pharmacology
Candida tropicalis/classification
Candida tropicalis/drug effects
Candida tropicalis/isolation & purification
Candidiasis/diagnosis
Candidiasis/drug therapy
Candidiasis/epidemiology
Drug Resistance, Fungal
Genetic Variation
Genotype
Humans
Kuwait/epidemiology
Microbial Sensitivity Tests
Multilocus Sequence Typing
Mycological Typing Techniques
Phylogeny
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antifungal Agents)
[Em] Entry month:1710
[Cu] Class update date: 171013
[Lr] Last revision date:171013
[Js] Journal subset:IM
[Da] Date of entry for processing:170831
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182292

  10 / 2695 MEDLINE  
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[PMID]: 28823262
[Au] Autor:Zhong FL; Zhang HY; Zhang Q; Zhang WL; Feng J; Meng QX
[Ad] Address:Department of Hematology, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China.
[Ti] Title:[Clinical Analysis of 10 Cases of B Cell Lymphoma-Associated Hemophagocytic Syndrome].
[So] Source:Zhongguo Shi Yan Xue Ye Xue Za Zhi;25(4):1022-1029, 2017 Aug.
[Is] ISSN:1009-2137
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To investigate the clinical and laboratory features of patient with B cell lymphoma associated hemophagocytic syndrome(B-LAHS). METHODS: The clinical data of 10 cases of B-LAHS were retrospectively analysed and the relevant literatures were reviewed. RESULTS: The median age of 10 cases diagnosed as B-LAHS was 55.5 (31-88) years old, and median time from attack to diagnosis was 2 months (2 weeks-4 months). The diagnosis can be made histopathologically and immunohistochemically by bone marrow biopsy. Among them 7 cases were diagnosed as large B cell lymphoma, 2 cases as mantle cell lymphoma and 1 case as small B cell lymphoma. The prominent clinical symptoms and signs were persistent fever (100%) and splenomegaly(90%), and the involvements with respiratory and digestive system were common. Another 1 case had systemic muscle pain and lactic acidosis as the first onset. Laboratory studies showed hepatic dysfunction, significantly elevated ferritin and lactate dehydrogenase, abnormal lymphocytes in peripheral blood smear, and hemophagocytosis in bone marrow smear. The FSC/SSC abnormalities of cloned B lymphoma cells were detected through flow cytometry (FCM). The complete remission (CR) was maintained in 4 cases receiving immunochemotherapy based on rituximab. CONCLUSION: B-LAHS possesses heterogeneous clinical manifestations and rapid deterioration. Bone marrow biopsy and immunohistochemical examination can confirm the diagnosis. FCM may improve the early diagnosis of B-LAHS.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170821
[Lr] Last revision date:170821
[St] Status:In-Data-Review
[do] DOI:10.7534/j.issn.1009-2137.2017.04.011


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