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[PMID]: 29338780
[Au] Autor:Yeo S; Tong L
[Ad] Address:Ocular Surface Research Group, Singapore Eye Research Institute, Singapore, Singapore.
[Ti] Title:Coping with dry eyes: a qualitative approach.
[So] Source:BMC Ophthalmol;18(1):8, 2018 Jan 16.
[Is] ISSN:1471-2415
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Dry eye is a common problem that affects many people worldwide, reducing quality of life and impacting daily activities. A qualitative approach often used in medicine and other disciplines is used to evaluate how people with dry eye cope with this impact. METHODS: Six focus group sessions were conducted at the Singapore National Eye Centre (SNEC), premises of an eye research institute. These focus groups consist of a spectrum of dry eye sufferers (30 women, 8 men, aged 61 ± 11.8 years). Standard methods of coding followed by determination of themes were adhered to. Where classification was difficult, consensus was made between 3 assessors. RESULTS: Audio-recorded transcripts were coded in 10 themes by 3 assessors independently. Four of the themes involved traditional measures such as lid warming, cleansing, lubrication and oral dietary supplements. The other themes discovered were Traditional Chinese Medicine, modification of eye-care habits (e.g. wearing sunglasses), environmental humidity, lifestyle (e.g. sleeping habits), psychological attitude, and lastly sharing and communication. CONCLUSION: Holistic coping strategies were found to be prominent in dry eye sufferers from these focus groups, and people tend to find personalised ways of coping with the impact of dry eye on daily living.
[Mh] MeSH terms primary: Adaptation, Psychological
Dry Eye Syndromes/psychology
Focus Groups/methods
Holistic Health
Quality of Life
[Mh] MeSH terms secundary: Adult
Aged
Aged, 80 and over
Dry Eye Syndromes/epidemiology
Female
Humans
Incidence
Male
Middle Aged
Singapore/epidemiology
Surveys and Questionnaires
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:IM
[Da] Date of entry for processing:180118
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0671-z

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[PMID]: 29390284
[Au] Autor:He Y; Li J; Zhu J; Jie Y; Wang N; Wang J
[Ad] Address:Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory.
[Ti] Title:The improvement of dry eye after cataract surgery by intraoperative using ophthalmic viscosurgical devices on the surface of cornea: The results of a consort-compliant randomized controlled trial.
[So] Source:Medicine (Baltimore);96(50):e8940, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUD: This study aimed to investigate the protective effect of intraoperative used hydroxypropyl methylcellulose (HPMC 2%) on the ocular surface after cataract surgery. METHODS: A total of 149 eyes (149 patients) diagnosed with age-related cataract, age 69.19 ±â€Š9.74 years, were enrolled in this prospective, parallel-design, continuous, randomised controlled study. Patients were randomly assigned to receive HPMC 2% (study group) or balanced salt solution (control group) during the surgery to moisturize the cornea surface. The Ocular Surface Disease Index, Schirmer test without topical anesthetics, tear break-up time, and corneal fluorescein staining were assessed preoperatively, 1 day, 1 week, and 1 month after the surgery, respectively. RESULTS: The Schirmer test value of male patients in the study group at 1 week postoperation was higher than that of male patients in the control group (P = .019). For patients diagnosed with dry eye before the surgery, Schirmer test value in the male patients in the study group at 1 month after surgery was higher than that in the male patients in the control group (P = .037). Furthermore, for the cluster of preoperative dry eye patients whose surgical time was longer than median, corneal fluorescein staining of the patients in the study group was superior to that of the patients in the control group (P = .032). CONCLUSION: Intraoperative use of HPMC 2% on the cornea surface could improve clinical outcomes of tear film and ocular surface health to some degree, especially in the patients diagnosed with dry eye before the surgery, male patients, and patients whose surgical time was relatively longer.
[Mh] MeSH terms primary: Cataract Extraction/methods
Dry Eye Syndromes/prevention & control
Hypromellose Derivatives/therapeutic use
Ophthalmic Solutions/therapeutic use
[Mh] MeSH terms secundary: Aged
Cornea
Dry Eye Syndromes/etiology
Female
Humans
Intraoperative Care
Male
Prospective Studies
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Name of substance:0 (Ophthalmic Solutions); 3NXW29V3WO (Hypromellose Derivatives)
[Em] Entry month:1802
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008940

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[PMID]: 29422755
[Au] Autor:Maharana PK; Raghuwanshi S; Chauhan AK; Rai VG; Pattebahadur R
[Ad] Address:Department of Ophthalmology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
[Ti] Title:Comparison of the Efficacy of Carboxymethylcellulose 0.5%, Hydroxypropyl-guar Containing Polyethylene Glycol 400/Propylene Glycol, and Hydroxypropyl Methyl Cellulose 0.3% Tear Substitutes in Improving Ocular Surface Disease Index in Cases of Dry Eye.
[So] Source:Middle East Afr J Ophthalmol;24(4):202-206, 2017 Oct-Dec.
[Is] ISSN:0975-1599
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:PURPOSE: To compare the efficacy of carboxymethylcellulose 0.5% (CMC), hydroxypropyl-guar containing polyethylene glycol 400/propylene glycol (PEG/PG), and hydroxypropyl methylcellulose 0.3% (HPMC) as tear substitutes in patients with dry eye. METHODS: A retrospective evaluation of cases presenting with symptoms of dry eye from July 2014 to June 2015 was done. Patients with Ocular Surface Disease Index (OSDI) scoring >12 were included in the study. Parameters such as age, gender, Schirmer test (ST), and tear film breakup time (TBUT) were recorded on day 0, week 1, and week 4. For analysis, cases were divided into three groups; Group 1 - CMC, Group 2 - PEG/PG, and Group 3 - HPMC. RESULTS: Overall, 120 patients were included in the study. Demographic data and baseline characteristics were comparable among the groups. Group 2 had significant improvement in percentage change in OSDI (weeks 0-1, 0-4, and 1-4, = 0.00), TBUT (weeks 0-1, = 0.01; 0-4, = 0.006; and 1-4, = 0.007), and in ST (weeks 0-1, = 0.02; 0-4, = 0.002; and 1-4, = 0.008) compared to Group 1 at all follow-ups. Group 3 had improvements similar to Group 2, but it was not at all follow-ups (improvement in percentage change OSDI [weeks 0-1, 0-4, and 1-4, = 0.00], TBUT [weeks 0-1, = 0.10; 0-4, = 0.03; and 1-4, = 0.04], and in ST [weeks 0-1, = 0.007; 0-4, = 0.03; and 1-4, = 0.12]). No significant difference was found between Groups 2 and 3. CONCLUSIONS: Hydroxypropyl-guar containing PEG/PG and HPMC as tear substitutes are better than CMC. While HPMC was comparable to PEG/PG in subjective improvement, the objective improvement was not consistent.
[Mh] MeSH terms primary: Carboxymethylcellulose Sodium/administration & dosage
Dry Eye Syndromes/drug therapy
Hypromellose Derivatives/administration & dosage
Lubricant Eye Drops/administration & dosage
Polysaccharides/administration & dosage
[Mh] MeSH terms secundary: Administration, Ophthalmic
Adult
Drug Combinations
Dry Eye Syndromes/physiopathology
Female
Humans
Male
Middle Aged
Ophthalmic Solutions
Polyethylene Glycols/chemistry
Polysaccharides/chemistry
Propylene Glycol/chemistry
Retrospective Studies
Tears/physiology
Treatment Outcome
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Name of substance:0 (Drug Combinations); 0 (Lubricant Eye Drops); 0 (Ophthalmic Solutions); 0 (Polysaccharides); 0 (hydroxypropyl guar); 30IQX730WE (Polyethylene Glycols); 3NXW29V3WO (Hypromellose Derivatives); 6DC9Q167V3 (Propylene Glycol); B697894SGQ (polyethylene glycol 400); K679OBS311 (Carboxymethylcellulose Sodium)
[Em] Entry month:1802
[Cu] Class update date: 180223
[Lr] Last revision date:180223
[Js] Journal subset:IM
[Da] Date of entry for processing:180210
[St] Status:MEDLINE
[do] DOI:10.4103/meajo.MEAJO_165_15

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[PMID]: 28452989
[Au] Autor:Labetoulle M; Chiambaretta F; Shirlaw A; Leaback R; Baudouin C
[Ad] Address:Service d'Ophtalmologie, CHU Bicêtre, APHP, Université Paris Sud, Paris, France.
[Ti] Title:Osmoprotectants, carboxymethylcellulose and hyaluronic acid multi-ingredient eye drop: a randomised controlled trial in moderate to severe dry eye.
[So] Source:Eye (Lond);31(10):1409-1416, 2017 Oct.
[Is] ISSN:1476-5454
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:PurposeTo assess the safety and efficacy of an eye drop combining osmoprotectants, carboxymethylcellulose and hyaluronic acid (O/CMC/HA) in reducing symptomatic, moderate to severe dry eye, compared with HA.MethodsIn this investigator-masked, randomised study, patients instilled 1-2 drops/eye of O/CMC/HA or HA (2-6 times/day) for 3 months. Primary endpoint: mean change in Global Ocular Staining Score (GOSS) from baseline at day 35. Noninferiority of O/CMC/HA was tested in the per-protocol population; if achieved, superiority was tested in the intent-to-treat population. Secondary efficacy endpoints: mean change from baseline in GOSS, Ocular Surface Disease Index (OSDI), Schirmer score, tear break-up time (TBUT), corneal/conjunctival staining, conjunctival hyperaemia, symptoms, and patient/investigator assessments.ResultsBaseline characteristics were comparable between groups (n=40 each). O/CMC/HA was noninferior (and not superior) to HA based on similar GOSS reductions from baseline at day 35 and month 3 in both groups (P=0.778, day 35, per-protocol population). Overall, O/CMC/HA and HA provided similar reductions in OSDI, Schirmer score, TBUT, corneal staining and hyperaemia from baseline at 35 days (P≥0.155). More patients reported less severe stinging/burning, sandiness/grittiness, and painful/sore eyes at month 3 with O/CMC/HA (P≤0.039), and more rated the dropper bottle easy to use (87.5%), compared with HA (46.2%; P=0.002). Other patient and investigator assessments were similar between groups. O/CMC/HA and HA were well tolerated.ConclusionsO/CMC/HA is noninferior to HA in improving objective signs of dry eye, with potential advantages for subjective symptoms and patient acceptance.
[Mh] MeSH terms primary: Carboxymethylcellulose Sodium/administration & dosage
Dry Eye Syndromes/drug therapy
Hyaluronic Acid/administration & dosage
Tears/chemistry
[Mh] MeSH terms secundary: Carboxymethylcellulose Sodium/pharmacokinetics
Dose-Response Relationship, Drug
Drug Administration Schedule
Dry Eye Syndromes/diagnosis
Female
Humans
Hyaluronic Acid/pharmacokinetics
Male
Middle Aged
Ophthalmic Solutions/administration & dosage
Osmosis/drug effects
Severity of Illness Index
Treatment Outcome
Viscosupplements/administration & dosage
Viscosupplements/pharmacokinetics
[Pt] Publication type:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Name of substance:0 (Ophthalmic Solutions); 0 (Viscosupplements); 9004-61-9 (Hyaluronic Acid); K679OBS311 (Carboxymethylcellulose Sodium)
[Em] Entry month:1802
[Cu] Class update date: 180223
[Lr] Last revision date:180223
[Js] Journal subset:IM
[Da] Date of entry for processing:170429
[St] Status:MEDLINE
[do] DOI:10.1038/eye.2017.73

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[PMID]: 29415667
[Au] Autor:Ren Y; Chen J; Zheng Q; Chen W
[Ad] Address:School of Ophthalmology and Optometry, Wenzhou Medical University, 270 Xueyuan West Road, Wenzhou, Zhejiang, 325027, People's Republic of China.
[Ti] Title:Short-term effect of a developed warming moist chamber goggle for video display terminal-associated dry eye.
[So] Source:BMC Ophthalmol;18(1):33, 2018 Feb 07.
[Is] ISSN:1471-2415
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Video display terminal (VDT)-associated dry eye (DE) patients are the rising group worldwide, and moisture goggles are the preferable treatment since they are capable of improving tear film stability and DE discomfort. The current study aims to evaluate the short-term efficacy and safety of the developed warming moist chamber goggles (WMCGs) for VDT-associated DE patients. METHODS: In this prospective self-control study, 22 DE patients (22 eyes) working with VDTs over 4 h daily were enrolled and instructed to wear WMCGs for 15 min. Sodium hyaluronate (SH, 0.1%) eyedrops were applied as a control on another day on these same patients, however 4 subjects denied the eyedrop application. The symptomatology visual analog scale (VAS) score, tear meniscus height (TMH), noninvasive tear film break-up time (NI-BUT), tear film lipid layer thickness (LLT), and bulbar conjunctival redness were assessed with Keratograph 5 M at baseline, 5, 30 and 60 min after treatment. The WMCGs wearing comfort was also evaluated. RESULTS: The ocular discomfort evaluated by VAS decreased in the WMCGs group throughout 60 min (P<0.001), better than the control group levels (P ≤ 0.015). TMH, NI-BUT (including the first BUT and average BUT) increased than baseline level accross 60 min in the WMCG group (P ≤ 0.012), while those in the control group only showed temporary improvements in 5 min. LLT also increased obviously after WMCGs wear, while the change in the control group was nearly innoticeable. No adverse responses were detected. CONCLUSIONS: Temporary use of the WMCGs is able to relieve ocular discomfort, and improves tear film stability in DE patients for at least 1 h, making it a promising alternative to other treatments.
[Mh] MeSH terms primary: Asthenopia/therapy
Computer Terminals
Dry Eye Syndromes/therapy
Eye Protective Devices
[Mh] MeSH terms secundary: Adult
Asthenopia/etiology
Dry Eye Syndromes/etiology
Equipment Design
Female
Humans
Humidity
Lipid Metabolism/physiology
Male
Prospective Studies
Tears/physiology
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[Js] Journal subset:IM
[Da] Date of entry for processing:180209
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0700-y

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[PMID]: 29391860
[Au] Autor:Galor A; Small L; Feuer W; Levitt RC; Sarantopoulos KD; Yosipovitch G
[Ad] Address:Miami Veterans Administration Medical Center, Miami, Florida (Dr Galor); Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami, Miami, Florida (Dr Galor, Dr Small, Mr Feuer); and Department of Anesthesiology, Perioperative Medicine and Pain Management (Dr Levitt, Dr Sarantopo
[Ti] Title:The Relationship Between Ocular Itch, Ocular Pain, and Dry Eye Symptoms (An American Ophthalmological Society Thesis).
[So] Source:Trans Am Ophthalmol Soc;115:T5, 2017 Aug.
[Is] ISSN:1545-6110
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Purpose: To evaluate associations between sensations of ocular itch and dry eye (DE) symptoms, including ocular pain, and DE signs. Methods: A cross-sectional study of 324 patients seen in the Miami Veterans Affairs eye clinic was performed. The evaluation consisted of questionnaires regarding ocular itch, DE symptoms, descriptors of neuropathic-like ocular pain (NOP), and evoked pain sensitivity testing on the forehead and forearm, followed by a comprehensive ocular surface examination including corneal mechanical sensitivity testing. Analyses were performed to examine for differences between those with and without subjective complaints of ocular itch. Results: The mean age was 62 years with 92% being male. Symptoms of DE and NOP were more frequent in patients with moderate-severe ocular itch compared to those with no or mild ocular itch symptoms. With the exception of ocular surface inflammation (abnormal matrix metalloproteinase 9 testing) which was less common in those with moderate-severe ocular itch symptoms, DE signs were not related to ocular itch. Individuals with moderate-severe ocular itch also demonstrated greater sensitivity to evoked pain on the forearm and had higher non-ocular pain, depression, and post-traumatic stress disorders scores, compared to those with no or mild itch symptoms. Conclusions: Subjects with moderate-severe ocular itch symptoms have more severe symptoms of DE, NOP, non-ocular pain and demonstrate abnormal somatosensory testing in the form of increased sensitivity to evoked pain at a site remote from the eye, consistent with generalized hypersensitivity.
[Mh] MeSH terms primary: Dry Eye Syndromes/diagnosis
Eye Diseases/diagnosis
Eye Pain/diagnosis
Pruritus/diagnosis
[Mh] MeSH terms secundary: Cornea/physiology
Cross-Sectional Studies
Dry Eye Syndromes/physiopathology
Eye Diseases/physiopathology
Eye Pain/physiopathology
Female
Humans
Male
Middle Aged
Ophthalmology/organization & administration
Pain Measurement
Pruritus/physiopathology
Quality of Life
Skin Physiological Phenomena
Societies, Medical
Surveys and Questionnaires
Tears/physiology
United States
Veterans
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[Js] Journal subset:IM
[Da] Date of entry for processing:180203
[St] Status:MEDLINE

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[PMID]: 29390975
[Au] Autor:Yao W; Le Q
[Ad] Address:Department of Ophthalmology, Eye & ENT Hospital of Fudan University, No.83 Fenyang Road, Shanghai, 200031, China.
[Ti] Title:Social-economic analysis of patients with Sjogren's syndrome dry eye in East China: a cross-sectional study.
[So] Source:BMC Ophthalmol;18(1):23, 2018 Feb 02.
[Is] ISSN:1471-2415
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Sjogren's syndrome is the leading cause for aqueous tear-deficiency dry eye. Little is known regarding the relationship between Sjogren's syndrome dry eye (SSDE) and patients' medical expenditure, clinical severity and psychological status changes. METHODS: Thirty-four SSDE patients and thirty non-Sjogren's syndrome dry eye (non-SSDE) subjects were enrolled. They were required to complete three self-report questionnaires: Ocular Surface Disease Index, Zung Self Rating Anxiety Scales, and a questionnaire designed by the researchers to study the patients' treatment, medical expenditure and income. The correlations between expenditures and these parameters were analyzed. RESULTS: The annual total expenditure on the treatment of SSDE was Chinese Yuan 7637.2 (approximately US$1173.8) on average, and the expense paid by SSDE patients themselves was Chinese Yuan 2627.8 (approximately US$403.9), which were 5.5 and 4.5 times higher than non-SSDE patients (both P < 0.001). The annual total expense on Chinese medicine and western medicine were 35.6 times and 78.4% higher in SSDE group than in non-SSDE group (both P < 0.001). Moreover, indirect costs associated with the treatment were 70.0% higher in SSDE group. In SSDE group, the score of Zung Self Rating Anxiety Scales had significantly positive correlation with total medical expenditure and the expense on Chinese medicine (ρ = 0.399 and ρ = 0.400,both P = 0.019). Nevertheless, total medical expenditure paid by the patients in non-SSDE group positively correlated with the score of Ocular Surface Disease Index (ρ = 0.386, P = 0.035). CONCLUSIONS: Medication expenditures and associated costs is an unignorable economic burden to the patients with SSDE. The medical expense had a significantly correlation with clinical severity of SSDE and the patients' psychological status.
[Mh] MeSH terms primary: Health Expenditures
Health Services Accessibility/economics
Sjogren´s Syndrome/economics
Socioeconomic Factors
[Mh] MeSH terms secundary: Activities of Daily Living
Adult
Aged
Asian Continental Ancestry Group/ethnology
China/epidemiology
Cross-Sectional Studies
Dry Eye Syndromes/drug therapy
Dry Eye Syndromes/economics
Dry Eye Syndromes/psychology
Female
Humans
Income
Male
Middle Aged
Sjogren's Syndrome/drug therapy
Sjogren's Syndrome/psychology
Surveys and Questionnaires
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[Js] Journal subset:IM
[Da] Date of entry for processing:180203
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0694-5

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[PMID]: 29429301
[Au] Autor:Yang X; Li Y
[Ad] Address:Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
[Ti] Title:[Research progress of corneal Langerhans cells' role in the pathogenesis of dry eye disease].
[So] Source:Zhonghua Yan Ke Za Zhi;54(2):149-153, 2018 Feb 11.
[Is] ISSN:0412-4081
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:Dry eye disease (DED) is the most common ocular surface diseasenowadays. DED can be divided into different types based on the pathogenesis. The progression of DED is strongly related to chronic ocular surface inflammation, regardless of the type of DED. The corneal Langerhans cells (LC) are the dedicated antigen presenting cells in the ocular surface immune system. Along with further understanding of LC recently, its double-sided functions have been discovered: on one hand, LC phagocytize antigen and induce immune tolerance, and on the other hand, LC process and present antigen, and initiate immune response. Therefore, the functional status of LC is of profound impact on the progression and prognosis of DED. Previous researches on DED pathogenesis were mainly focused on T lymphocyte while the importance of LC have not been emphasized. This article reviews the researches on corneal LC in DED of recent years. .
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180212
[Lr] Last revision date:180212
[St] Status:In-Data-Review
[do] DOI:10.3760/cma.j.issn.0412-4081.2018.02.017

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[PMID]: 29429300
[Au] Autor:Lin X; Liu ZL; Wu JL; Liu ZG
[Ad] Address:Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen University affiliated Xiamen Eye Center, Xiamen 361102, China.
[Ti] Title:[Research progress of conscious pain and neurosensory abnormalities in dry eye disease].
[So] Source:Zhonghua Yan Ke Za Zhi;54(2):144-148, 2018 Feb 11.
[Is] ISSN:0412-4081
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:Dry eye is one of the most common ocular problems in ophthalmology clinic. With the change of social environment and people's life style, the prevalence of dry eye disease is increasing. Currently, the diagnosis criteria for dry eye is controversial, diagnosis of dry eye mainly rely on the comprehensive assessment of symptoms and the presence of associated ocular surface signs. However, previous studies have shown a poor correlation between dry eye symptoms and objective clinical signs in patients. Recent studies have found that neuropathic pain plays an important role in the occurrence of discordance between symptoms and signs in dry eye disease. The purpose of this paper is to present the conception of pain, the distribution and function of sensory nerves in ocular surface, the prevalence and mechanism of neuropathic pain and analgesic treatment in dry eye disease. .
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180212
[Lr] Last revision date:180212
[St] Status:In-Data-Review
[do] DOI:10.3760/cma.j.issn.0412-4081.2018.02.016

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[PMID]: 29429299
[Au] Autor:Song WJ; Yan XM
[Ad] Address:Department of Ophthalmology, the First Hospital of Peking University, Beijing 100034, China.
[Ti] Title:[Research progress of intense pulsed light treatment on meibomian gland dysfunction and relevant dry eye diseases].
[So] Source:Zhonghua Yan Ke Za Zhi;54(2):140-143, 2018 Feb 11.
[Is] ISSN:0412-4081
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:Intense pulsed light (IPL) is a broad spectrum incoherent light which is produced by high-output xenon lamp. Since the invention of the first-generation IPL in 1994, IPL technology has been developing rapidly and extensively utilized in multiple fields relevant to dermatology across the world. In 2004, the fourth-generation IPL system was introduced with the optimal pulse technology (OPT) and has soon been used for cosmetic purposes all over the world. In 2002, Dr. Toyos found that the meibomian gland dysfunction (MGD) and dye eye disease (DED)symptoms of the rosacea patients who received IPL treatment have been improving significantly, therefore he started to explore the application of IPL system to treatment of dry eye disease. Several recent clinical studies have demonstrated the therapeutic potential of IPL for improving the symptoms and signs of MGD and DED. However, the published data of IPL treatment for MGD and DED is limited, the mechanism of IPL treatment for MGD and DED remained unclear and more relevant researches needed to be done in the future. This article discusses the clinical application history and general mechanism of IPL, and introduces the treatment of IPL for MGD and DED. .
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180212
[Lr] Last revision date:180212
[St] Status:In-Data-Review
[do] DOI:10.3760/cma.j.issn.0412-4081.2018.02.015


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