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[PMID]: 29515738
[Au] Autor:Nazeer A; Rai AA; Luck NH
[Ad] Address:Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi.
[Ti] Title:Factors leading to dyspepsia in renal transplant recipients.
[So] Source:Pan Afr Med J;28:120, 2017.
[Is] ISSN:1937-8688
[Cp] Country of publication:Uganda
[La] Language:eng
[Ab] Abstract:Introduction: Renal transplantation is the definitive treatment for end stage renal disease. Patients subjected to transplantation require lifelong immunosuppression and are prone to several gastrointestinal disorders. Dyspepsia is a common disorder in these patients. The objective of this study was to determine factors leading to dyspepsia in renal (kidney) transplant recipients. Methods: It was a cross sectional study conducted at department of hepatogastroenterology and transplant sciences, SIUT Karachi, from 1-6-15 to 1-12-15 for six months. All renal transplanted patients having dyspeptic symptoms for more than 6 weeks. EGD was performed, biopsy specimens obtained from antrum and duodenum, these were sent for histopathological examination. Frequency and percentages were obtained for categorical variables, mean ± SD was calculated for continuous variables. Chi square test was used for categorical variable and student t-test for continuous variables. Results: Ninety patients were included in the study out of which 64 (71.1%) were males, mean age was 35.82 ± 10.04 years (range: 18-65 years). Gastritis (non associated) in 78 (78.6%), duodenitis in 35 (38.9%) and infection in 29 (32.2%), renal transplant recipients. Most of the patients belonged to Sindhi ethnicity, 27 (30%), followed by Punjabi. Hypertension was the most common co-morbid condition in our patients found in 29 (32.2%), while most of them don't have any co morbid condition. Duodenitis was found to be associated with tacrolimus use (p = 0.037). Conclusion: Gastritis is the most common factor accountable for this symptoms, followed by duodenitis and . Patients taking tacrolimus as immunosuppressant are more prone to develop duodenitis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Process
[do] DOI:10.11604/pamj.2017.28.120.12767

  2 / 12145 MEDLINE  
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[PMID]: 29515732
[Au] Autor:Chouchaine A; Fodha M; Abdelkefi MT; Helali K; Fodha M
[Ad] Address:Service de Chirurgie Générale, Hôpital Taher Sfar, Mahdia, Tunisie.
[Ti] Title:Agénésie de la vésicule biliaire: à propos de trois cas. [Gallbladder agenesis: about three cases].
[So] Source:Pan Afr Med J;28:114, 2017.
[Is] ISSN:1937-8688
[Cp] Country of publication:Uganda
[La] Language:fre
[Ab] Abstract:Gallbladder agenesis is a rare congenital anomaly. This study aimed to highlight the epidemiological aspects of this condition as well as the peculiarities of its diagnostic and therapeutic management through three case reports. Two adults were admitted to Hospital with hepatic colics and dyspepsia. Ultrasound showed multilithiasic scleroatrophic vesicle. In one of the two patients, CT scan results showed a stone at the level of scleroatrophic vesicle. These two patients were wrongly operated for vesicular lithiasis by using conventional method. The absence of gallbladder was detected during surgery. In order to confirm post-operative diagnosis, the first patient underwent biliary MRI. The other patient was lost to follow-up. The third patient was a 13-year old child hospitalized with acute pancreatitis. Vesicular agenesis was suspected based on its scannographic aspect and then confirmed using biliary MRI. This patient didn't underwent surgery.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Process
[do] DOI:10.11604/pamj.2017.28.114.11919

  3 / 12145 MEDLINE  
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[PMID]: 29522108
[Au] Autor:Dainton C; Chu CH
[Ad] Address:Grand River Hospital, Kitchener, ON, Canada.
[Ti] Title:A review of gastrointestinal protocols for primary care medical service trips (MSTs) in Latin America and the Caribbean.
[So] Source:Int Health;, 2018 Mar 07.
[Is] ISSN:1876-3405
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Background: Gastrointestinal disorders are among the most common conditions encountered on short-term, primary care medical service trips (MSTs) in Latin America and the Caribbean (LAC), but their optimal management remains unclear. There have been no previous attempts to describe the protocols that Western volunteer clinicians use in managing these patients. Methods: A systematic web search was used to identify organizations operating MSTs in LAC. Clinical protocols were downloaded from organizational websites, and organizations were contacted online to obtain those that were not publicly available. Protocols were analysed qualitatively, and content compared with existing international guidelines. Results: Two hundred and twenty-five organizations were identified and contacted to obtain their clinical protocols, and the content of each protocol was qualitatively analysed. Twenty protocols were obtained, of which 75% (15/20) discussed dyspepsia, 65% (13/20) discussed parasites and 60% (12/20) discussed diarrhoea. The protocols infrequently included literature citations. Conclusion: Gastrointestinal disorder protocols used by MSTs in LAC sometimes neglected important aspects of clinical management that are emphasized in international guidelines. This study is a first step in context-specific clinical guideline development for MSTs operating in LAC.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1093/inthealth/ihy005

  4 / 12145 MEDLINE  
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[PMID]: 29520918
[Au] Autor:Smeets FGM; Masclee AAM; Conchillo JM; Keszthelyi D
[Ad] Address:Division of Gastroenterology-Hepatology, Department of Internal Medicine, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands.
[Ti] Title:Systematic review: Disease-specific instruments to assess gastrointestinal symptoms in functional dyspepsia.
[So] Source:Neurogastroenterol Motil;, 2018 Mar 09.
[Is] ISSN:1365-2982
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Functional dyspepsia (FD) is a common functional gastrointestinal disorder with incompletely understood pathophysiology and heterogeneous symptom presentation. Assessment of treatment efficacy in FD is a methodological challenge as response to treatment must be assessed primarily by measuring subjective symptoms. Therefore, the use of patient-reported outcome measures (PROMs) is recommended by regulatory authorities to assess gastrointestinal symptoms in clinical trials for FD. In the last decades, a multitude of outcome measures has been developed. However, currently no PROM has been approved by the regulatory authorities, and no consensus has been reached with regard to the most relevant outcome measure in FD. PURPOSE: This systematic review discusses the available disease-specific outcome measures for assessment of FD symptoms with psychometric validation properties, strengths, and limitations. Moreover, recommendations for use of current available outcome measures are provided, and potential areas of future research are discussed.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1111/nmo.13327

  5 / 12145 MEDLINE  
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[PMID]: 29519989
[Au] Autor:Ray-Offor E; Obiorah CC
[Ad] Address:Digestive Disease Unit, Oak Endoscopy Centre Port Harcourt; Departments of Surgery, University of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State, Nigeria.
[Ti] Title: and precancerous lesions of the stomach in a Nigerian Metropolis: A Cohort Study.
[So] Source:Niger J Clin Pract;21(3):375-379, 2018 Mar.
[Is] ISSN:1119-3077
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Introduction: Helicobacter pylori (H. pylori)-related atrophic gastritis transits through a sequential pathway of intestinal metaplasia, dysplasia to gastric cancer. Gastroscopy offers early detection, treatment and surveillance of gastric cancer. Aims: This study aims to study the prevalence of H. pylori infection and evaluate precancerous lesions (PCLs) of the stomach. Patients and Methods: This is a case controlled study of patients with dyspepsia undergoing gastroscopy at a referral endoscopy facility in Port Harcourt metropolis of Nigeria. The variables studied included demographics, clinical, endoscopic, and histopathologic findings. Statistical analysis of data was done using IBM SPSS Statistics for Windows, Version 20.0. (Armonk, NY, USA). Results: A total of 104 patients were included in the study. Age ranged from 20 to 80 years (mean 47.1 ± 14.4 years); 56 were males and 48 were females. H. pylori were detected in 40 (38.5%) mucosal biopsies. The prevalence of PCLs was: chronic atrophic gastritis 6.7% (7 cases); intestinal metaplasia 2.9% (3 cases); and dysplasia 5.8% (6 cases). There was no statistical significance in sex distribution of PCLs (P = 0.245). Conclusion: There is a low prevalence of H. pylori in this metropolitan population. Mandatory multiple topographically targeted biopsies, even with normal mucosal appearance, at gastroscopy in addition to surveillance of PCL are recommended for early detection of gastric cancer.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process
[do] DOI:10.4103/njcp.njcp_302_17

  6 / 12145 MEDLINE  
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[PMID]: 29368191
[Au] Autor:Dutta AK; Reddy VD; Iyer VH; Unnikrishnan LS; Chacko A
[Ad] Address:Department of Gastrointestinal Sciences, Christian Medical College and Hospital, Vellore, 632 004, India. akdutta1995@gmail.com.
[Ti] Title:Exploring current status of Helicobacter pylori infection in different age groups of patients with dyspepsia.
[So] Source:Indian J Gastroenterol;36(6):509-513, 2017 Nov.
[Is] ISSN:0975-0711
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Recent data from Asian countries including India has shown a significant decline in the frequency of peptic ulcer disease (PUD) compared to the past. H. pylori is considered the most important risk factor for PUD, and we aimed to explore the current frequency of H. pylori infection in different age groups of patients with dyspepsia. Patients >15 years of age with dyspeptic symptoms were prospectively recruited in this study from 2010 to 2014 after obtaining informed consent. Patients were divided into three age groups: 15-30 years, 31-50 years, and >50 years, and the minimum sample size required in the three groups with a power of 90% was 259, 256, and 188, respectively. All patients underwent upper gastrointestinal endoscopy; rapid urease test was done on gastric mucosal biopsy to detect H. pylori. The clinical, demographic features and socioeconomic status were recorded. The institute review board approved the study. We included 1000 patients with dyspepsia during the study period. Their mean age was 40.0+13.3 years, and 69.3% were males. Infection with H. pylori was detected in 419 (41.9%) patients. Among men, H. pylori was present in 45.7% while the frequency of infection in women was lower at 33.2% (p < 0.001). In the 15-30 years age group (n = 303), the frequency of infection was 42.6% while it was 48.3% in the 31-50 years group (n = 350) and 34.9% in the above 50 years group (n = 347). Male sex was a significant risk factor for H. pylori infection (p < 0.001). H. pylori infection, an important risk factor for PUD, was detected in less than half of the dyspeptic patients in the current study.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review
[do] DOI:10.1007/s12664-017-0810-0

  7 / 12145 MEDLINE  
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[PMID]: 29385513
[Au] Autor:Koo MM; von Wagner C; Abel GA; McPhail S; Hamilton W; Rubin GP; Lyratzopoulos G
[Ad] Address:University College London, 1-19 Torrington Place, London WC1E 6BT, UK.
[Ti] Title:The nature and frequency of abdominal symptoms in cancer patients and their associations with time to help-seeking: evidence from a national audit of cancer diagnosis.
[So] Source:J Public Health (Oxf);, 2018 Jan 27.
[Is] ISSN:1741-3850
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Background: Raising awareness of possible cancer symptoms is important for timely help-seeking; recent campaigns have focused on symptom groups (such as abdominal symptoms) rather than individual alarm symptoms associated with particular cancer sites. The evidence base supporting such initiatives is still emerging however; understanding the frequency and nature of presenting abdominal symptoms among cancer patients could inform the design and evaluation of public health awareness campaigns. Methods: We examined eight presenting abdominal symptoms (abdominal pain, change in bowel habit, bloating/distension, dyspepsia, rectal bleeding, dysphagia, reflux and nausea/vomiting) among 15 956 patients subsequently diagnosed with cancer in England. We investigated the cancer site case-mix and variation in the patient interval (symptom-onset-to-presentation) by abdominal symptom. Results: Almost a quarter (23%) of cancer patients presented with abdominal symptoms before being diagnosed with one of 27 common and rarer cancers. The patient interval varied substantially by abdominal symptom: median (IQR) intervals ranged from 7 (0-28) days for abdominal pain to 30 (4-73) days for dysphagia. This variation persisted after adjusting for age, sex and ethnicity (P < 0.001). Conclusions: Abdominal symptoms are common at presentation among cancer patients, while time to presentation varies by symptom. The need for awareness campaigns may be greater for symptoms associated with longer intervals to help-seeking.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1093/pubmed/fdx188

  8 / 12145 MEDLINE  
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[PMID]: 28452210
[Au] Autor:Talley NJ
[Ad] Address:Faculty of Health and Medicine, University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW, Australia.
[Ti] Title:Functional Dyspepsia: Advances in Diagnosis and Therapy.
[So] Source:Gut Liver;11(3):349-357, 2017 May 15.
[Is] ISSN:2005-1212
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:Functional dyspepsia (FD) is a common but under-recognized syndrome comprising bothersome recurrent postprandial fullness, early satiety, or epigastric pain/burning. Epidemiologically, there are two clinically distinct FD syndromes (although these often overlap clinically): postprandial distress syndrome (PDS; comprising early satiety or meal-related fullness) and epigastric pain syndrome. Symptoms of gastroesophageal reflux disease overlap with FD more than expected by chance; a subset has pathological acid reflux. The pretest probability of FD in a patient who presents with classical FD symptoms and no alarm features is high, approximately 0.7. Coexistent heartburn should not lead to the exclusion of FD as a diagnosis. One of the most exciting observations in FD has been the consistent finding of increased duodenal eosinophilia, notably in PDS. Small bowel homing T cells, signaling intestinal inflammation, and increased cytokines have been detected in the circulation, and elevated tumor necrosis factor-α levels have been significantly correlated with increased anxiety. Postinfectious gastroenteritis is a risk factor for FD. Therapeutic options remain limited and provide only symptomatic benefit in most cases. Only one therapy is known to change the natural history of FD- eradication. Treatment of duodenal eosinophilia is under investigation.
[Mh] MeSH terms primary: Dyspepsia/diagnosis
Dyspepsia/therapy
Postprandial Period
Symptom Assessment
[Mh] MeSH terms secundary: Diagnosis, Differential
Duodenal Diseases/complications
Duodenal Diseases/diagnosis
Dyspepsia/etiology
Eosinophilia/complications
Eosinophilia/diagnosis
Gastroesophageal Reflux/complications
Gastroesophageal Reflux/diagnosis
Heartburn/complications
Heartburn/diagnosis
Helicobacter Infections/complications
Helicobacter Infections/drug therapy
Helicobacter pylori
Humans
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[Js] Journal subset:IM
[Da] Date of entry for processing:170429
[St] Status:MEDLINE
[do] DOI:10.5009/gnl16055

  9 / 12145 MEDLINE  
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[PMID]: 29513301
[Au] Autor:Velázquez-Dohorn ME; López-Durand CF; Gamboa-Domínguez A
[Ad] Address:Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
[Ti] Title:Changing Trends in Gastric Polyps.
[So] Source:Rev Invest Clin;70(1):40-45, 2018.
[Is] ISSN:0034-8376
[Cp] Country of publication:Mexico
[La] Language:eng
[Ab] Abstract:Background: The prevalence of gastric polyps varies around the world reflecting regional associations. We describe demographic features of patients with gastric polyp diagnosis treated between 1980 and 2016 at a referral center in Mexico City and analyzed trends of polyp subtype. Materials and Methods: We conducted a blind review of archival slides of gastric biopsies with polyp diagnosis from the years 1980, 1990, 2000, 2010, and 2016. Initial diagnosis; patient's gender, age and symptoms; and number and location of lesions were recorded. Blind slide review and trend analysis were performed. Results: In 3887 gastric biopsies, 192 patients (4.93%) with epithelial polyps were identified. The median age of patients was 58 years; 73% were female. Polyps were single in 143/192 cases (74.4%), almost 67% in the oxyntic mucosa, and 85% were associated with dyspepsia. The prevalence was 0.5%, 1.6%, 1.9%, 4.6%, and 9.6% for the years 1980, 1990, 2000, 2010, and 2016, respectively, resulting in a rising trend in the prevalence of epithelial polyps of 380% in 46 years. Fundic gland polyps (FGPs) had a global frequency of 66.6% (128/192). They were identified for the first time in the third period of the study, with a frequency of 28.6% (6/21), 66.6% (35/53), and 78.3% (87/111) for the years 2000, 2010, and 2016, respectively. Contrary, hyperplastic polyps (HPs) decreased 20%. A relative prevalence of 3.29%, 0.97%, and 0.15% was observed for FGP, HP, and gastric adenoma, respectively. Discussion: The 1400% change of FGP explains the increased prevalence of gastric polyps. Chronic treatment with proton pump inhibitors and Helicobacter pylori eradication are possible explanations.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process
[do] DOI:10.24875/RIC.17002430

  10 / 12145 MEDLINE  
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[PMID]: 29209863
[Au] Autor:Schoenmakers TWA; Wensing M; De Smet PAGM; Teichert M
[Ad] Address:Department of IQ Healthcare, Radboud Institute for Health Sciences, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands. tim.schoenmakers@radboudumc.nl.
[Ti] Title:Patient-reported common symptoms as an assessment of interventions in medication reviews: a randomised, controlled trial.
[So] Source:Int J Clin Pharm;40(1):126-134, 2018 Feb.
[Is] ISSN:2210-7711
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Background A 'Patient-Reported Outcome Measure, Inquiry into Side Effects' (PROMISE) instrument was developed for patients to report common symptoms in clinical medication reviews. Objective To determine changes in patient-reported drug-associated symptoms collected by PROMISE before and after community pharmacist-led clinical medication reviews compared with usual care. Setting Community pharmacies in the Netherlands. Methods Patients were randomised into an intervention group (IG) and a control group (CG). PROMISE was used to collect symptoms experienced during the previous month, and any suspected drug-associated symptoms from both groups at baseline and at follow-up after 3 months. IG patients received a one-time clinical medication review, while CG patients received usual care. Main outcome measure Mean number of drug-associated symptoms at follow-up. Results Measurements were completed by 78 IG and 67 CG patients from 15 community pharmacies. Mean numbers of drug-associated symptoms per patient at follow-up were 4.0 in the IG and 5.0 in the CG, with an incident rate ratio between the groups of 0.90 (95% CI 0.62-1.33). Mean numbers of drug-associated symptoms per patient reported at follow-up and persisting since baseline were 2.1 in the IG and 2.6 in the CG, with an incident rate ratio of 0.85 (95% CI 0.43-1.42). The lowest percentages of persisting drug-associated symptoms detected in the IG were 'palpitations' and 'stomach pain, dyspepsia' while in the CG they were 'stomach pain, dyspepsia' and 'trembling, shivering'. Conclusion PROMISE provided meaningful information on drug-associated symptoms in clinical medication reviews, however the number of drug-associated symptoms was not reduced by performing clinical medication reviews compared with usual care.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process
[do] DOI:10.1007/s11096-017-0575-7


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