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[PMID]: 29408160
[Au] Autor:Choi SB; Lee W; Yoon JH; Won JU; Kim DW
[Ad] Address:Department of Medical Engineering, Yonsei University College of Medicine, Seoul, Republic of Korea; Graduate Program in Biomedical Engineering, Yonsei University, Seoul, Republic of Korea.
[Ti] Title:Ten-year prediction of suicide death using Cox regression and machine learning in a nationwide retrospective cohort study in South Korea.
[So] Source:J Affect Disord;231:8-14, 2018 Apr 15.
[Is] ISSN:1573-2517
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: Death by suicide is a preventable public health concern worldwide. The aim of this study is to investigate the probability of suicide death using baseline characteristics and simple medical facility visit history data using Cox regression, support vector machines (SVMs), and deep neural networks (DNNs). METHOD: This study included 819,951 subjects in the National Health Insurance Service (NHIS)-Cohort Sample Database from 2004 to 2013. The dataset was divided randomly into two independent training and validation groups. To improve the performance of predicting suicide death, we applied SVM and DNN to the same training set as the Cox regression model. RESULTS: Among the study population, 2546 people died by intentional self-harm during the follow-up time. Sex, age, type of insurance, household income, disability, and medical records of eight ICD-10 codes (including mental and behavioural disorders) were selected by a Cox regression model with backward stepwise elimination. The area of under the curve (AUC) of Cox regression (0.688), SVM (0.687), and DNN (0.683) were approximately the same. The group with top .5% of predicted probability had hazard ratio of 26.21 compared to that with the lowest 10% of predicted probability. LIMITATIONS: This study is limited by the lack of information on suicidal ideation and attempts, other potential covariates such as information of medication and subcategory ICD-10 codes. Moreover, predictors from the prior 12-24 months of the date of death could be expected to show better performances than predictors from up to 10 years ago. CONCLUSIONS: We suggest a 10-year probability prediction model for suicide death using general characteristics and simple insurance data, which are annually conducted by the Korean government. Suicide death prevention might be enhanced by our prediction model.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review

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[PMID]: 29364542
[Au] Autor:Yelehe-Okouma M; Czmil-Garon J; Pape E; Petitpain N; Gillet P
[Ad] Address:Centre Régional de Pharmacovigilance, CHRU de Nancy, Hôpital Central, 29, avenue du Maréchal de Lattre de Tassigny, 60034, 54035, Nancy, France.
[Ti] Title:Drug-induced aseptic meningitis: a mini-review.
[So] Source:Fundam Clin Pharmacol;, 2018 Jan 24.
[Is] ISSN:1472-8206
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Aseptic meningitis associates a typical clinical picture of meningitis with the absence of bacterial or fungal material in the cerebrospinal fluid. Drug-induced aseptic meningitis (DIAM) may be due to two mechanisms: (i) a direct meningeal irritation caused by the intrathecal administration of drugs and (ii) an immunologic hypersensitivity reaction to a systemic administration. If the direct meningeal irritation allows a rather easy recognition, the immunologic hypersensitivity reaction is a source of challenging diagnostics. DIAM linked to a systemic treatment exerts typically an early onset, usually within a week. This period can be shortened to a few hours in case of drug rechallenge. The fast and spontaneous regression of clinical symptoms is usual after stopping the suspected drug. Apart from these chronological aspects, no specific clinical or biological parameters are pathognomonic. CSF analysis usually shows pleiocytosis. The proteinorachia is increased while glycorachia remains normal. Underlying pathologies can stimulate the occurrence of DIAM. Thus, systemic lupus erythematosus appears to promote DIAM during NSAID therapy, especially ibuprofen-based one. Similarly, some patients with chronic migraine are prone to intravenous immunoglobulin-induced aseptic meningitis. DIAM will be mainly evoked on chronological criteria such as rapid occurrence after initiation, rapid regression after discontinuation, and recurrence after rechallenge of the suspected drug. When occurring, positive rechallenge may be very useful in the absence of initial diagnosis. Finally, DIAM remains a diagnosis of elimination. It should be suggested only after all infectious causes have been ruled out.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1801
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1111/fcp.12349

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[PMID]: 29436577
[Au] Autor:Sun Y; Liu L; Yuan J; Sun Q; Wang N; Wang Y
[Ad] Address:Department of Neurology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
[Ti] Title:RP105 protects PC12 cells from oxygen­glucose deprivation/reoxygenation injury via activation of the PI3K/AKT signaling pathway.
[So] Source:Int J Mol Med;41(5):3081-3089, 2018 May.
[Is] ISSN:1791-244X
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:Radioprotective 105 kDa protein (RP105) has been reported to produce favorable outcomes in various cardiovascular disorders via a toll­like receptor 4­dependent or ­independent manner. However, whether RP105 exerts neuroprotective effects against oxygen­glucose deprivation (OGD)/reoxygenation (OGD/R) injury remains to be elucidated. In the present study, the PC12 neuronal cell line was exposed to 4 h of OGD followed by 24 h of reoxygenation. Adenoviral vectors encoding RP105 were utilized to upregulate the level of RP105 in PC12 cells prior to OGD/R induction. The results demonstrated that OGD/R reduced the expression of RP105 at the mRNA and protein levels. The overexpression of RP105 significantly reversed OGD/R­induced neuronal injuries, as demonstrated by the reduced release of lactate dehydrogenate and enhanced cellular viability, in addition to decreased inflammation, apoptosis and reactive oxygen species. The mechanistic evaluations indicated that the neuroprotective functions of RP105 were, in part, a result of activation of the phosphatidylinositol 3­kinase (PI3K)/protein kinase B (AKT) pathway. In addition, elimination of the PI3K/AKT axis via the use of a pharmacological inhibitor inhibited the OGD/R­inhibitory effects induced by the overexpression of RP105. Taken together, RP105 protected PC12 cells from OGD/R injury through promotion of the PI3K/AKT pathway; therefore, the RP105­PI3K­AKT axis may provide a novel therapeutic target for the prevention of cerebral ischemia/reperfusion injury.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process
[do] DOI:10.3892/ijmm.2018.3482

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[PMID]: 29179825
[Au] Autor:Siess J; Schalast N
[Ad] Address:Institut für Forensische Psychiatrie, Universität Duisburg-Essen, LVR-Klinikum Essen, Postfach 103043, 45030 Essen, Germany. Electronic address: julia.siess@uni-due.de.
[Ti] Title:Psychometric Properties of the Essen Climate Evaluation Schema (EssenCES) in a Sample of General Psychiatric Wards.
[So] Source:Arch Psychiatr Nurs;31(6):582-587, 2017 12.
[Is] ISSN:1532-8228
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The questionnaire EssenCES (Essen Climate Evaluation Schema) is a widely used instrument to assess social climate in forensic psychiatric and correctional institutions. The purpose of this study was to evaluate the EssenCES in a general psychiatric setting, where it had not previously been evaluated. DESIGN: 648 staff members and 551 patients from 47 general psychiatric wards across 16 hospitals in Germany completed the EssenCES. Factor-, correlation- and scale-analyses were carried out to inspect the questionnaire's properties. RESULTS: The proposed three-dimensional factor structure of the instrument was confirmed. Results indicated that the EssenCES subscales Patients' Cohesion and Experienced Safety had high internal consistency, whereas elimination of item 16 would improve the internal consistency of Therapeutic Hold. Correlations between the EssenCES subscales and other measures supported the validity of the questionnaire. CONCLUSION: The results suggest that the EssenCES is suitable for usage in general psychiatric settings. Along with its brevity, it seems useful as an economic and valid screening instrument for a ward's social climate. Reasons are given why item 16 should be retained.
[Mh] MeSH terms primary: Attitude of Health Personnel
Mental Disorders/psychology
Psychiatric Department, Hospital
Psychometrics/statistics & numerical data
Social Environment
[Mh] MeSH terms secundary: Adult
Female
Forensic Psychiatry
Germany
Humans
Inpatients/psychology
Male
Reproducibility of Results
Self Report
Surveys and Questionnaires
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1802
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[Js] Journal subset:IM; N
[Da] Date of entry for processing:171129
[St] Status:MEDLINE

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[PMID]: 29500536
[Au] Autor:Perez-Rando M; Castillo-Gomez E; Bueno-Fernandez C; Nacher J
[Ad] Address:Neurobiology Unit, Cell Biology Department, Program in Neurosciences and Interdisciplinary Research Structure for Biotechnology and Biomedicine (BIOTECMED), Universitat de València, Dr. Moliner, 50, Burjassot, 46100, Spain.
[Ti] Title:The TrkB agonist 7,8-dihydroxyflavone changes the structural dynamics of neocortical pyramidal neurons and improves object recognition in mice.
[So] Source:Brain Struct Funct;, 2018 Mar 02.
[Is] ISSN:1863-2661
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:BDNF and its receptor TrkB have important roles in neurodevelopment, neural plasticity, learning, and memory. Alterations in TrkB expression have been described in different CNS disorders. Therefore, drugs interacting with TrkB, specially agonists, are promising therapeutic tools. Among them, the recently described 7,8-dihydroxyflavone (DHF), an orally bioactive compound, has been successfully tested in animal models of these diseases. Recent studies have shown the influence of this drug on the structure of pyramidal neurons, specifically on dendritic spine density. However, there is no information yet on how DHF may alter the structural dynamics of these neurons (i.e., real-time study of the addition/elimination of dendritic spines and axonal boutons). To gain knowledge on these effects of DHF, we have performed a real-time analysis of spine and axonal dynamics in pyramidal neurons of barrel cortex, using cranial windows and 2-photon microscopy during a chronic oral treatment with this drug. After confirming TrkB expression in these neurons, we found that DHF increased the gain rates of spines and axonal boutons, as well as improved object recognition memory. These results help to understand how the activation of the BDNF-TrkB system can improve basic behavioral tasks through changes in the structural dynamics of pyramidal neurons. Moreover, they highlight DHF as a promising therapeutic vector for certain brain disorders in which this system is altered.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180303
[Lr] Last revision date:180303
[St] Status:Publisher
[do] DOI:10.1007/s00429-018-1637-x

  6 / 6028 MEDLINE  
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[PMID]: 29425005
[Au] Autor:Novikova IV; Agafonov GV; Korotkikh EA; Kalaev VN; Nechaeva MS; Mal'tseva OY
[Ti] Title:[Evaluation of antimutagenic properties of powdered malt and polymalt extracts with the use of micronucleus test].
[So] Source:Gig Sanit;95(7):669-75, 2016.
[Is] ISSN:0016-9900
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:There were performed studies of the occurrence of cells with pathologies in the buccal epithelium of volunteers who consume drinks based on mixtures ofpowdered malt and polymalt extracts of buckwheat, peas, corn and barley. There was shown their impact on the stability of the genetic material of examined cases. There was established activation of apoptosis, which leads to the elimination of cells with cytogenetic deteriorations. Poliymalt extracts possess protective properties, contribute to the suppression ofprocesses offormation of cells with genetic disorders (micronuclei (from 4.38 ± 0.67 %%, up to 2.53 ± 0.39 %% after intake), protrusions (from 1,98 ± 0,42 %%, up 0,85 ± 0,25 %% after intake), incisures (from 3.34 ± 0.44 %%, up 2.17 ± 0.35 %% after intake), two cores (from 1.63 ± 0.26 %%, up 0.65 ± 0.21 %% after intake) and rid the body of aberrant cells, as evidenced by the increase in the number of cells with karyolysis (up to 5.98 ± 0,91 %%, up 9.55 ± 1.74 %% after intake), karyopyknosis (from 10.71 ± 0.90 %%, up to 11.97 ± 0.85 %% after intake) and perinuclear vacuoles (from 9.24 ± 1.63 %%, up to 12.94 ± 2.57 %% after intake). In women, anti-mutagenic effects ofpolymalt extracts are more pronounced than in men. Antimutagenic effects of extracts can be explained by the properties of contained in them B vitamins and sulfur-containing amino acids (cysteine and methionine).
[Mh] MeSH terms primary: Antimutagenic Agents/pharmacology
Edible Grain
Plant Extracts/pharmacology
[Mh] MeSH terms secundary: Antioxidants/pharmacology
Female
Humans
Male
Micronucleus Tests/methods
Mouth Mucosa/pathology
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antimutagenic Agents); 0 (Antioxidants); 0 (Plant Extracts)
[Em] Entry month:1803
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:IM
[Da] Date of entry for processing:180210
[St] Status:MEDLINE

  7 / 6028 MEDLINE  
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[PMID]: 29424207
[Au] Autor:Mirskaya NB; Sinyakina AD; Kolomenskaya AN
[Ti] Title:[Shaping a healthy lifestyle as necessary condition for prevention of disorders and diseases of visual organ in younger schoolchildren].
[So] Source:Gig Sanit;95(5):466-70, 2016.
[Is] ISSN:0016-9900
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:Purpose. Study of the lifestyle and identification of behavioral risk factors negatively affecting on the state of the visual organ in primary school children. Patients and methods. There was performed a questionnaire survey of parents of 384 younger schoolchildren in Moscow. Questionnaire specially designed by authors included questions relating to lifestyle and behavioral risk factors that affect vision. Results. More than 46% of the younger schoolchildren in the mode of the day have no daily walks in the fresh air, including during daylight hours in 51.6%; time daily needed for this age on air is spent by only 32.8% of schoolchildren. Among younger schoolchildren every day 57.2%, 44.8% and 39.5% spend longer time than needed for homework, TV and computer correspondingly; all the time only 9.4% keepproperfit at their desk, 15.6% at the computer, 20.8% - when watch television; 40.6% do not constantly comply with the requirements for proper illumination while watching TV; 45.8% sometimes read in lyingposition , 9.9% - in transport. Conclusion. Identified in junior schoolchildren of the city of Moscow a high prevalence of behavioral risk factors that negatively affect their visual organ and health in general, requires the elimination of these factors by means of hygienic education and shaping a healthy lifestyle in schoolchildren since 1st grade.
[Mh] MeSH terms primary: Attitude to Computers
Healthy Lifestyle/physiology
School Health Services/organization & administration
Vision Disorders
[Mh] MeSH terms secundary: Child
Female
Humans
Male
Needs Assessment
Parents/psychology
Risk Assessment/statistics & numerical data
Risk Factors
Russia/epidemiology
Surveys and Questionnaires
Vision Disorders/epidemiology
Vision Disorders/etiology
Vision Disorders/prevention & control
Vision Disorders/psychology
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:IM
[Da] Date of entry for processing:180210
[St] Status:MEDLINE

  8 / 6028 MEDLINE  
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[PMID]: 29400049
[Au] Autor:Wang R; Han X; You J; Yu F; Chen L
[Ad] Address:Key Laboratory of Life-Organic Analysis, Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, College of Chemistry and Chemical Engineering, Qufu Normal University , Qufu 273165, China.
[Ti] Title:Ratiometric Near-Infrared Fluorescent Probe for Synergistic Detection of Monoamine Oxidase B and Its Contribution to Oxidative Stress in Cell and Mice Aging Models.
[So] Source:Anal Chem;, 2018 Mar 02.
[Is] ISSN:1520-6882
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:As new biomarkers, monoamine oxidases (MAOs) play important roles in maintaining the homeostasis of biogenic amines via catalyzing the oxidation of biogenic amines to corresponding aldehydes with the generation of reactive oxygen species (ROS). MAOs have two isoforms, MAO-A and MAO-B. MAO-A is considered to be a major factor of neuropsychiatric and depressive disorders. However, MAO-B is thought to be involved in several neurodegenerative diseases. Therefore, to explore their distinct roles in different diseases, the selective detection of MAOs is essential. Herein, two new types of near-infrared (NIR) fluorescent probes, MitoCy-NH and MitoHCy-NH , are provided for synergistic imaging of MAO-B and its contribution to oxidative stress in cells and in mice aging models. These probes are composed of three moieties: heptamethine cyanine as fluorophore, propanamide as recognition group, and triphenylphosphonium cation as mitochondrial targeting group. The amine oxidation and ß-elimination reaction can lead to obvious fluorescence increase and color changes from green to blue. The probe MitoHCy-NH can be used to synergistically detect MAO-B and its contribution to oxidative stress in the replicative senescence model. And the probe MitoCy-NH can offer ratiometric near-infrared fluorescence for the selective detection of MAO-B in the H O -induced cell aging model and in mice aging models. The results reveal that there are different MAO-B levels in different ages of mice models. MitoCy-NH also can evaluate therapeutic effects of pargyline and selegiline in mice models. The desirable analytical behaviors of our probes make them useful chemical tools for the selective detection of MAO-B and its contribution to oxidative stress in biosystems.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:Publisher
[do] DOI:10.1021/acs.analchem.7b05297

  9 / 6028 MEDLINE  
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[PMID]: 29318513
[Au] Autor:Yang Y; Wu H; Kang X; Liang Y; Lan T; Li T; Tan T; Peng J; Zhang Q; An G; Liu Y; Yu Q; Ma Z; Lian Y; Soh BS; Chen Q; Liu P; Chen Y; Sun X; Li R; Zhen X; Liu P; Yu Y; Li X; Fan Y
[Ad] Address:Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
[Ti] Title:Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs.
[So] Source:Protein Cell;9(3):283-297, 2018 Mar.
[Is] ISSN:1674-8018
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Mitochondrial diseases are maternally inherited heterogeneous disorders that are primarily caused by mitochondrial DNA (mtDNA) mutations. Depending on the ratio of mutant to wild-type mtDNA, known as heteroplasmy, mitochondrial defects can result in a wide spectrum of clinical manifestations. Mitochondria-targeted endonucleases provide an alternative avenue for treating mitochondrial disorders via targeted destruction of the mutant mtDNA and induction of heteroplasmic shifting. Here, we generated mitochondrial disease patient-specific induced pluripotent stem cells (MiPSCs) that harbored a high proportion of m.3243A>G mtDNA mutations and caused mitochondrial encephalomyopathy and stroke-like episodes (MELAS). We engineered mitochondrial-targeted transcription activator-like effector nucleases (mitoTALENs) and successfully eliminated the m.3243A>G mutation in MiPSCs. Off-target mutagenesis was not detected in the targeted MiPSC clones. Utilizing a dual fluorescence iPSC reporter cell line expressing a 3243G mutant mtDNA sequence in the nuclear genome, mitoTALENs displayed a significantly limited ability to target the nuclear genome compared with nuclear-localized TALENs. Moreover, genetically rescued MiPSCs displayed normal mitochondrial respiration and energy production. Moreover, neuronal progenitor cells differentiated from the rescued MiPSCs also demonstrated normal metabolic profiles. Furthermore, we successfully achieved reduction in the human m.3243A>G mtDNA mutation in porcine oocytes via injection of mitoTALEN mRNA. Our study shows the great potential for using mitoTALENs for specific targeting of mutant mtDNA both in iPSCs and mammalian oocytes, which not only provides a new avenue for studying mitochondrial biology and disease but also suggests a potential therapeutic approach for the treatment of mitochondrial disease, as well as the prevention of germline transmission of mutant mtDNA.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[St] Status:In-Data-Review
[do] DOI:10.1007/s13238-017-0499-y

  10 / 6028 MEDLINE  
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[PMID]: 28464931
[Au] Autor:Wulf MA; Senatore A; Aguzzi A
[Ad] Address:Institute of Neuropathology, University of Zurich, Rämistrasse 100, CH-8091, Zürich, Switzerland.
[Ti] Title:The biological function of the cellular prion protein: an update.
[So] Source:BMC Biol;15(1):34, 2017 05 02.
[Is] ISSN:1741-7007
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The misfolding of the cellular prion protein (PrP ) causes fatal neurodegenerative diseases. Yet PrP is highly conserved in mammals, suggesting that it exerts beneficial functions preventing its evolutionary elimination. Ablation of PrP in mice results in well-defined structural and functional alterations in the peripheral nervous system. Many additional phenotypes were ascribed to the lack of PrP , but some of these were found to arise from genetic artifacts of the underlying mouse models. Here, we revisit the proposed physiological roles of PrP in the central and peripheral nervous systems and highlight the need for their critical reassessment using new, rigorously controlled animal models.
[Mh] MeSH terms primary: Central Nervous System/pathology
Peripheral Nervous System/pathology
Prion Diseases/metabolism
Prion Proteins/metabolism
[Mh] MeSH terms secundary: Animals
Disease Models, Animal
Mice
Prion Diseases/etiology
Prion Proteins/toxicity
[Pt] Publication type:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Prion Proteins)
[Em] Entry month:1801
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:IM
[Da] Date of entry for processing:170504
[St] Status:MEDLINE
[do] DOI:10.1186/s12915-017-0375-5


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