Database : MEDLINE
Search on : Empty and Sella and Syndrome [Words]
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[PMID]: 29510819
[Au] Autor:Auer MK; Stieg MR; Crispin A; Sievers C; Stalla GK; Kopczak A
[Ad] Address:Department of Clinical Neuroendocrinology, Max Planck Institute of Psychiatry, Munich; Department of Medicine IV, Ludwig-Maximilians-Universität München, Munich; Institute for Medical Data Processing, Biometrics and Epidemiology, Ludwig-Maximilians- Universität München, Munich.
[Ti] Title:Primary Empty Sella Syndrome and the Prevalence of Hormonal Dysregulation.
[So] Source:Dtsch Arztebl Int;115(7):99-105, 2018 Feb 16.
[Is] ISSN:1866-0452
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:BACKGROUND: Empty sella is the neuroradiological or pathological finding of an apparently empty sella turcica containing no pituitary tissue. The prevalence of primary empty sella, i.e., empty sella without any discernible cause, is not precisely known; estimates range from 2% to 20%. Technical advances in neuroradiology have made empty sella an increasingly common incidental finding. It remains unclear whether, and to what extent, asymptomatic adult patients with an incidentally discovered empty sella should undergo diagnostic testing for hormonal disturbances. METHODS: To answer this question, the authors carried out a systematic search in the PubMed and Web of Science databases for publications that appeared in the period 1995-2016 and that contained the search term "empty sella" (registration: PROSPERO 2015: CRD42015024550). RESULTS: The search yielded 1282 hits. After the exclusion of duplicates, pediatric reports, case reports, and veterinary studies, 120 publications on primary empty sella syndrome (PES) were identified. 4 of these dealt with the prevalence of pituitary insufficiency in patients with PES as an incidental finding. Among patients with PES, the relative frequency of pituitary insufficiency in the pooled analysis was 52% (95% confidence interval [38; 65]). CONCLUSION: The data on PES as an incidental finding are too sparse to enable any evidence-based recommendation on the potential indications for hormone testing or its nature and extent. We advise basic neuroendocrinological testing (fasting cortisol, free thyroxine [fT4], estradiol or testosterone, insulin-like growth factor 1 [IGF-1], and prolactin). There is an unexplained discrepancy between the reported high prevalence of pituitary insufficiency among persons with PES and its low prevalence in epidemiologic studies. We suspect that the former may be high because of selection bias in the publications that we reviewed, or else the latter may be erroneously low.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Data-Review

  2 / 1221 MEDLINE  
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[PMID]: 29421446
[Au] Autor:In-Ping Huang Cobb M; Mintz-Cole R; Husain AM; Berger M; Jang D; Codd P
[Ad] Address:Department of Neurosurgery, Duke University Hospitals. Electronic address: maryih.cobb@duke.edu.
[Ti] Title:Transnasal transphenoidal elevation of optic chiasm in secondary empty sella syndrome following prolactinoma treatment.
[So] Source:World Neurosurg;, 2018 Feb 05.
[Is] ISSN:1878-8769
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Prolactinomas are typically treated non-surgically with a dopamine agonist. However, once the tumor shrinks, adjacent eloquent structures such as the optic apparatus can become skeletonized and herniate into the dilated parasellar space. CASE DESCRIPTION: We describe here a 48-year-old man with a prolactin-secreting macroadenoma treated with cabergoline who presented with progressive bitemporal hemianopsia. MRI showed no recurrence of disease and a stretched optic chiasm herniating into an empty sella. He underwent a transnasal transphenoidal approach elevation of the optic chiasm with an alloderm graft and septal cartilage strut. He was discharged home the next day with significant improvement in his vision and an MRI showing interval elevation of the optic chiasm. CONCLUSIONS: We review here secondary empty sella syndrome and discuss surgical strategies for optic chiasmapexy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180208
[Lr] Last revision date:180208
[St] Status:Publisher

  3 / 1221 MEDLINE  
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[PMID]: 29187947
[Au] Autor:Taieb A; Maha KN; El Abed YH; Beizig AM; Chadli MC; Ach K
[Ad] Address:Endocrinology and Diabetes Department, University Hospital Farhat Hached Sousse, Tunisia.
[Ti] Title:Macroprolactinemia and Empty Sella Syndrome.
[So] Source:Pan Afr Med J;27:278, 2017.
[Is] ISSN:1937-8688
[Cp] Country of publication:Uganda
[La] Language:eng
[Ab] Abstract:Macroprolactinemia is a polymeric form of prolactin-release, causing mildly symptomatic clinical pictures. The former can be isolated or associated with other causes of hyperprolactinemia. The association with an empty sella syndrome is rare. We report a case of a female patient discovered with this association. It's about a female patient 47 years old, followed up since the age of 31 years for bilateral galactorrhea and a spaniomenorrhea. There has been no associated drug intake. Her exploration has showed a serum prolactin level of 635 mIU/L. Thyroid test results were normal T4 = 10,2ng/L and TSH = 1.76 mIU/L. A brain scan has showed an empty sella turcica. Despite the unchanged levels of prolactinemia, the evolution under dopaminergic 5 mg /D has been marked by the occurrence of a pregnancy with persistent moderate hyperprolactinemia in the postpartum. Chromatography has showed a predominance of the macroprolactin form with: Prolactin monomer at 4.8%, Big Prolactin at 5% and Big Big Prolactin at 83%, thus stopping bromocriptine. Our observation suggests that macroprolactinemia can be associated with conventional etiologies of moderate hyperprolactinemia as the empty sella syndrome. Its detection would prevent the use of dopaminergic therapy which seems not useful.
[Mh] MeSH terms primary: Empty Sella Syndrome/diagnosis
Hyperprolactinemia/etiology
Prolactin/blood
[Mh] MeSH terms secundary: Bromocriptine/administration & dosage
Dopamine Agonists/administration & dosage
Empty Sella Syndrome/complications
Female
Humans
Middle Aged
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Dopamine Agonists); 0 (prolactin, polymeric); 3A64E3G5ZO (Bromocriptine); 9002-62-4 (Prolactin)
[Em] Entry month:1712
[Cu] Class update date: 171219
[Lr] Last revision date:171219
[Js] Journal subset:IM
[Da] Date of entry for processing:171201
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.278.11361

  4 / 1221 MEDLINE  
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[PMID]: 29027644
[Au] Autor:Barzaghi LR; Donofrio CA; Panni P; Losa M; Mortini P
[Ad] Address:Pituitary Unit of the Department of Neurosurgery and Gamma Knife Radiosurgery, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy.
[Ti] Title:Treatment of empty sella associated with visual impairment: a systematic review of chiasmapexy techniques.
[So] Source:Pituitary;, 2017 Oct 13.
[Is] ISSN:1573-7403
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: Chiasmapexy is a poorly described surgical procedure adopted to correct the downward displacement of suprasellar visual system (SVS) into an empty sella (ES) causing visual worsening. The aim of our study is to define the indications for extradural and intradural chiasmapexy. METHODS: A systematic literature review has been performed on MEDLINE database (US National Library of Medicine), including only articles that depicted cases of surgically treated patients affected by ES and progressive delayed visual worsening. Moreover, we have reported three cases of secondary ES syndrome (SESS) with visual worsening treated in our Department with transsphenoidal (TS) microsurgical intradural approach. Finally, we have compared the results of extradural and intradural chiasmapexy described in literature. RESULTS: The etiology of visual impairment is different in primary and secondary ESS. In primary ESS (PESS) the only predisposing factor is a dehiscence of diaphragma sellae, and the anatomical distortion caused by displacement of optic chiasm or traction of pituitary stalk and infundibulum may determine a direct injury of neural fibers and ischemic damage of SVS. In PESS the mechanical elevation of SVS performed through extradural approach is sufficient to resolve the main pathologic mechanism. In SESS, arachnoidal adhesions play an important role in addition to downward herniation of SVS. Consequently, the surgical technique should provide elevation of SVS combined to intradural release of scar tissue and arachnoidal adhesions. In treatment of SESS, the intradural approaches result to be more effective, guaranteeing the best visual outcomes with the lowest complications rates. CONCLUSIONS: The intradural chiasmapexy is indicated in treatment of SESS, instead the extradural approaches are suggested for surgical management of PESS.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1710
[Cu] Class update date: 171014
[Lr] Last revision date:171014
[St] Status:Publisher
[do] DOI:10.1007/s11102-017-0842-6

  5 / 1221 MEDLINE  
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[PMID]: 28843758
[Au] Autor:Tsukiyama A; Hattori Y; Tahara S; Ishisaka E; Morimoto D; Oyama K; Teramoto A; Morita A
[Ad] Address:Department of Neurosurgery, Nippon Medical School, Tokyo, Japan.
[Ti] Title:New Technique for Chiasmapexy Using Iliac Crest Bone Graft: 2 Cases of Visual Impairment Caused by Empty Sella Syndrome.
[So] Source:World Neurosurg;107:1051.e19-1051.e25, 2017 Nov.
[Is] ISSN:1878-8769
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Chiasmapexy is used to treat empty sella syndrome, and various materials are used for the elevation of the optic chiasm. However, the use of artificial substances may have the risk of graft infection, and fat and muscle may be absorbed over the long term after surgery. In addition, bone and cartilage may be unavailable in adequate amounts. Here, we describe a new technique for chiasmapexy using an iliac crest bone graft. CASE DESCRIPTION: The first patient was a 71-year-old woman who had undergone transsphenoidal surgery twice for the treatment of pituitary adenoma and Rathke cleft cyst. The optic chiasm collapsed after the second surgery and her visual field worsened gradually. We performed chiasmapexy using fat, fascia, and a septal mucosal flap, but the optic chiasm did not remain in the normal position because of graft shrinkage. Finally, we used an iliac crest bone graft, which resulted in good visual function. The second patient was a 58-year-old man who was incidentally diagnosed with empty sella syndrome. The patient's bitemporal hemianopia gradually progressed. As in the first case, we used an iliac crest bone graft, which halted the deterioration of visual function after chiasmapexy. CONCLUSIONS: The advantages of iliac bone are that it is less likely to absorb and become infected than synthetic materials. This method may be suitable for reoperative cases, especially those wherein the septal cartilage has been removed in a previous surgery. This method will halt visual deterioration and may be one of the considerable options for chiasmapexy operations.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 171024
[Lr] Last revision date:171024
[St] Status:In-Data-Review

  6 / 1221 MEDLINE  
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[PMID]: 28780516
[Au] Autor:Chiloiro S; Giampietro A; Bianchi A; Tartaglione T; Capobianco A; Anile C; De Marinis L
[Ad] Address:Pituitary UnitDepartment of Endocrinology.
[Ti] Title:DIAGNOSIS OF ENDOCRINE DISEASE: Primary empty sella: a comprehensive review.
[So] Source:Eur J Endocrinol;177(6):R275-R285, 2017 Dec.
[Is] ISSN:1479-683X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Primary empty sella (PES) is characterized by the herniation of the subarachnoid space within the sella, which is often associated with variable degrees of flattening of the pituitary gland in patients without previous pituitary pathologies. PES pathogenetic mechanisms are not well known but seem to be due to a sellar diaphragm incompetence, associated to the occurrence of upper sellar or pituitary factors, as intracranial hypertension and change of pituitary volume. As PES represents in a majority of cases, a neuroradiological findings without any clinical implication, the occurrence of endocrine, neurological and opthalmological symptoms, due to the above describes anatomical alteration, which delineates from the so called PES syndrome. Headache, irregular menses, overweight/obesity and visual disturbances compose the typical picture of PES syndrome and can be the manifestation of an intracranial hypertension, often associated with PES. Although hyperprolactinemia and growth hormone deficit represent the most common endocrine abnormalities, PES syndrome is characterized by heterogeneity both in clinical manifestation and hormonal alterations and can sometime reach severe extremes, as occurrence of papilledema, cerebrospinal fluid rhinorrhea and worsening of visual acuity. Consequently, a multidisciplinary approach, with the integration of endocrine, neurologic and ophthalmologic expertise, is strongly advocated and recommended for a properly diagnosis, management, treatment and follow-up of PES syndrome and all of the related abnormalities.
[Mh] MeSH terms primary: Asymptomatic Diseases
Empty Sella Syndrome/diagnosis
Encephalocele/diagnosis
Pituitary Gland/diagnostic imaging
Sella Turcica/diagnostic imaging
Subarachnoid Space/diagnostic imaging
[Mh] MeSH terms secundary: Empty Sella Syndrome/diagnostic imaging
Empty Sella Syndrome/physiopathology
Empty Sella Syndrome/therapy
Encephalocele/diagnostic imaging
Encephalocele/physiopathology
Encephalocele/therapy
Human Growth Hormone/deficiency
Human Growth Hormone/secretion
Humans
Hyperprolactinemia/etiology
Hyperprolactinemia/prevention & control
Intracranial Hypertension/etiology
Intracranial Hypertension/prevention & control
Magnetic Resonance Imaging
Neuroimaging
Papilledema/etiology
Papilledema/prevention & control
Pituitary Gland/physiopathology
Pituitary Gland/secretion
Sella Turcica/physiopathology
Severity of Illness Index
Subarachnoid Space/physiopathology
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:12629-01-5 (Human Growth Hormone)
[Em] Entry month:1710
[Cu] Class update date: 171020
[Lr] Last revision date:171020
[Js] Journal subset:IM
[Da] Date of entry for processing:170807
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0505

  7 / 1221 MEDLINE  
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[PMID]: 28642181
[Au] Autor:Wang Q; Guo X; Gao L; Wang Z; Deng K; Lian W; Wang R; Zhu H; Xing B
[Ad] Address:Department of Neurosurgery, Peking Union Medical College Hospital, Beijing, China; Peking Union Medical College, Beijing, China.
[Ti] Title:Surgical Outcome of Growth Hormone-Secreting Pituitary Adenoma with Empty Sella Using a New Classification.
[So] Source:World Neurosurg;105:651-658, 2017 Sep.
[Is] ISSN:1878-8769
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To investigate outcomes and identified risk factors affecting cure and intraoperative cerebrospinal fluid leak after transsphenoidal surgery using a new classification for growth hormone-secreting pituitary adenoma associated with empty sella. METHODS: In this retrospective cohort study, 51 patients enrolled from January 2010 to June 2016 were categorized into 3 groups using a new classification scheme: grade A, whole tumor occupation area beneath a horizontal line drawn along the lowest level of empty sella; grade B, tumor occupation area that crossed the horizontal line on 1 side; and grade C, tumor occupation area that crossed the horizontal line on 2 sides. Clinical data were collected and analyzed. RESULTS: Cure rate for grade A patients (88.24%; 15/17) was significantly higher than cure rate for grade B (55.00%; 11/20) and grade C (50.00%; 7/14) patients. Occurrence of cerebrospinal fluid leaks in grade C patients (35.71%; 5/14) was higher than in grade A patients (5.88%; 1/17). Logistic regression analysis indicated that risk factors affecting cure included large maximum tumor diameter (P = 0.009, odds ratio [OR] = 1.222), high preoperative fasting growth hormone level (P = 0.031, OR = 1.088), and high classification (P = 0.017, OR = 4.485). Risk factor affecting intraoperative cerebrospinal fluid leak was high classification (P = 0.039, OR = 3.580). CONCLUSIONS: Transsphenoidal surgery is the current optimal treatment strategy. Empty sella increases the difficulty of surgery with a higher incidence of complications. The new classification scheme was better for predicting the surgical outcome for this disease.
[Mh] MeSH terms primary: Adenoma/classification
Adenoma/surgery
Empty Sella Syndrome/classification
Empty Sella Syndrome/surgery
Human Growth Hormone/secretion
Pituitary Neoplasms/classification
Pituitary Neoplasms/surgery
[Mh] MeSH terms secundary: Adult
Aged
Female
Follow-Up Studies
Humans
Male
Middle Aged
Retrospective Studies
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:12629-01-5 (Human Growth Hormone)
[Em] Entry month:1710
[Cu] Class update date: 171004
[Lr] Last revision date:171004
[Js] Journal subset:IM
[Da] Date of entry for processing:170624
[St] Status:MEDLINE

  8 / 1221 MEDLINE  
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[PMID]: 28587427
[Au] Autor:Xu C; Zhang X; Dong L; Zhu B; Xin T
[Ad] Address:Department of Radiology, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221002, P.R. China.
[Ti] Title:MRI features of growth hormone deficiency in children with short stature caused by pituitary lesions.
[So] Source:Exp Ther Med;13(6):3474-3478, 2017 Jun.
[Is] ISSN:1792-0981
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:We verified the advantages of using magnetic resonance imaging (MRI) for improving the diagnostic quality of growth hormone deficiency (GHD) in children with short stature caused by pituitary lesions. Clinical data obtained from 577 GHD patients with short stature caused by pituitary lesions were retrospectively analyzed. There were 354 cases (61.3%) with anterior pituitary dysplasia; 45 cases (7.8%) of pituitary stalk interruption syndrome (PSIS); 15 cases (2.6%) of pituitary hyperplasia due to primary hypothyroidism; 38 cases (6.6%) of Rathke cleft cyst; 68 cases (11.8%) of empty sella syndrome; 16 cases (2.8%) of pituitary invasion from Langerhans cell histiocytosis; 2 cases (0.3%) of sellar regional arachnoid cyst and 39 cases (6.8%) of craniopharyngioma. MRI results showed that the height of anterior pituitary in patients was less than normal. Location, size and signals of posterior pituitary and pituitary stalk were normal in anterior pituitary dysplasia. In all cases pituitary hyperplasia was caused by hypothyroidism. MRI results showed that anterior pituitary was enlarged, and we detected upward apophysis and obvious homogeneous enhancement. There were no pituitary stalk interruption and abnormal signal. We also observed that after hormone replacement therapy the size of pituitary gland was reduced. Anterior pituitary atrophy was observed in Rathke cleft cyst, empty sella syndrome, sellar regional arachnoid cyst and craniopharyngioma. The microstructure of hypophysis and sellar region was studied with MRI. We detected pituitary lesions, and the characteristics of various pituitary diseases of GHD in children with short stature. It was concluded that in children with GHD caused by pituitary lesions, MRI was an excellent method for early diagnosis. This method offers clinical practicability and we believe it can be used for differential diagnosis and to monitor the therapeutic effects.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1706
[Cu] Class update date: 170816
[Lr] Last revision date:170816
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.3892/etm.2017.4377

  9 / 1221 MEDLINE  
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[PMID]: 28552871
[Au] Autor:Mizuno Y; Yamaguchi H; Uehara T; Yamashita K; Yamasaki R; Kira JI
[Ad] Address:Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University.
[Ti] Title:A case of stiff-person syndrome due to secondary adrenal insufficiency.
[So] Source:Rinsho Shinkeigaku;57(6):298-302, 2017 06 28.
[Is] ISSN:1882-0654
[Cp] Country of publication:Japan
[La] Language:jpn
[Ab] Abstract:We report a case of flexion contractures in a patient's legs secondary to postpartum hypopituitarism. A 56-year-old woman presented with a 3-year history of worsening flexion contractures of the hips and knees. On admission, her hips and knees could not be extended, and she had muscle stiffness and tenderness to palpation of the lower extremities. We first suspected stiff-person syndrome or Isaacs' syndrome because of her muscle stiffness. However, multiple hormones did not respond to stimulation tests, and an MRI of the brain showed atrophy of the pituitary gland with an empty sella. A subsequent interview revealed that she had suffered a severe hemorrhage while delivering her third child. She was diagnosed with panhypopituitarism and started on cortisol replacement therapy. After 1 week of treatment with hydrocortisone (10 mg/day), her symptoms quickly improved. We then added 75 µg/day of thyroid hormone. During the course of her treatment, autoantibodies against VGKC complex were found to be weakly positive. However, we considered the antibodies to be unrelated to her disease, because her symptoms improved markedly with low-dose steroid treatment. There are a few reports describing flexion contractures of the legs in patients with primary and secondary adrenal insufficiency. As these symptoms are similar to those seen in stiff-person syndrome, adrenal and pituitary insufficiency should be taken into account to achieve the correct diagnosis and treatment in patients with flexion contractures and muscle stiffness.
[Mh] MeSH terms primary: Hypopituitarism/diagnosis
Isaacs Syndrome/diagnosis
Stiff-Person Syndrome/diagnosis
[Mh] MeSH terms secundary: Atrophy
Autoantibodies/blood
Biomarkers/blood
Diagnosis, Differential
Drug Administration Schedule
Drug Therapy, Combination
Female
Humans
Hydrocortisone/administration & dosage
Hypopituitarism/diagnostic imaging
Hypopituitarism/drug therapy
Middle Aged
Pituitary Gland/pathology
Thyroid Hormones/administration & dosage
Thyroxine/administration & dosage
Treatment Outcome
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Autoantibodies); 0 (Biomarkers); 0 (Thyroid Hormones); Q51BO43MG4 (Thyroxine); WI4X0X7BPJ (Hydrocortisone)
[Em] Entry month:1709
[Cu] Class update date: 171012
[Lr] Last revision date:171012
[Js] Journal subset:IM
[Da] Date of entry for processing:170530
[St] Status:MEDLINE
[do] DOI:10.5692/clinicalneurol.cn-001008

  10 / 1221 MEDLINE  
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[PMID]: 28355719
[Au] Autor:Li J; Jia HW; Wang CL; Zhang R; Qu MY; Li W; Yuan MH; Cui J; He Q; Wei HY; Zhu TH; Ma ZS; Liu W; Dong ZL; Gao ZG
[Ad] Address:Department of Endocrinology and Metabolism, General Hospital of Tianjin Medical University, Tianjin 300052, China.
[Ti] Title:[A clinical analysis of 123 cases of primary empty sella].
[So] Source:Zhonghua Nei Ke Za Zhi;56(4):268-272, 2017 Apr 01.
[Is] ISSN:0578-1426
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:This study was conducted to analyze the clinical characteristics and pituitary function of patients with primary empty sella (PES). The clinical data from 123 hospitalized adult patients with PES from January 2010 to May 2016 were retrospectively studied. (1) The average age of the 123 (male 43, female 80) PES patients was (59.2±13.6) years (ranging 24-92 years), among whom 61% patients were in the age group between 50-69 years. (2) The symptoms of the patients included fatigue (56.1%), headache (34.1%), nausea and vomiting (17.9%), gonadal dysfunction (17.1%), visual disturbance (5.7%) and hypopituitarism crisis (3.3%). (3) Hypopituitarism was found in 66 of the 123 patients. Among them, 36.6%, 31.7% and 17.1% were central hypoadrenalism, hypogonadism, and hypothyroidism, respectively.The percentage of hypopituitarism in complete PES was significantly higher than that in partial PES ( <0.05). (4) Sixteen patients were concomitant with other autoimmune diseases including 11 patients with Graves' disease and 2 with Cushing's syndrome due to adrenal adenoma. The incidence of hypopituitarism in PES was 53.7%, in which the pituitary-adrenal axis hypofunction was more common. An overall evaluation of the pituitary function was essential for the patients who had headache and fatigue, or with suspected PES. The patients with hypopituitarism should be given hormone replacement therapy in time and followed up afterword.
[Mh] MeSH terms primary: Empty Sella Syndrome/complications
Hypopituitarism/etiology
Hypothyroidism/etiology
Pituitary Gland/physiology
[Mh] MeSH terms secundary: Adrenal Insufficiency/complications
Adult
Aged
Aged, 80 and over
China/epidemiology
Empty Sella Syndrome/diagnosis
Empty Sella Syndrome/physiopathology
Fatigue/etiology
Female
Headache/etiology
Humans
Hypogonadism/complications
Hypopituitarism/diagnosis
Hypopituitarism/epidemiology
Hypothyroidism/diagnosis
Incidence
Male
Middle Aged
Retrospective Studies
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170731
[Lr] Last revision date:170731
[Js] Journal subset:IM
[Da] Date of entry for processing:170330
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0578-1426.2017.04.006


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