Database : MEDLINE
Search on : Encephalomalacia [Words]
References found : 2924 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 293 go to page                         

  1 / 2924 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 29523004
[Au] Autor:Pschibul A; Janzarik WG; Franck P; Hufnagel M; Beck C; Korinthenberg R
[Ad] Address:Department of Neuropediatrics and Muscle Disorders, University of Freiburg, Freiburg, Germany.
[Ti] Title:Cystic Encephalomalacia following Vasculopathy and Vasospasm of Proximal Intracranial Arteries Due to Pneumococcal Meningitis in a Infant.
[So] Source:Neuropediatrics;, 2018 Mar 09.
[Is] ISSN:1439-1899
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Despite the availability of modern antibiotics, pneumococcal meningitis in both children and adults remains a severe disease-one known to frequently cause grave complications and residual disability. Although the appearance of arterial vasospasms in bacterial meningitis systematically has been investigated and reported on for adult patients, such research is lacking when it comes to infants. We report on a 4-week-old infant who, 6 days after onset of pneumococcal meningitis, suffered severe neurological deterioration with treatment-resistant seizures and coma. Generalized cortical and subcortical edema developed in conjunction with diminished cerebral blood flow, as depicted in magnetic resonance angiography and serial Doppler-sonographic examinations. The ischemia resulted in extensive cystic encephalomalacia. We propose that the degree of variation in cerebral blood flow in the acute phase was the result of an extensive arterial vasculopathy involving vasospasms. Awareness of this complication and prospective serial Doppler-sonographic examinations may improve our understanding of the connection between brain edema and vasculopathy. At present, however, no effective treatment appears available.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1055/s-0038-1635075

  2 / 2924 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29487082
[Au] Autor:Xu D; Robinson AP; Ishii T; Duncan DS; Alden TD; Goings GE; Ifergan I; Podojil JR; Penaloza-MacMaster P; Kearney JA; Swanson GT; Miller SD; Koh S
[Ad] Address:Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
[Ti] Title:Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy.
[So] Source:J Exp Med;, 2018 Feb 27.
[Is] ISSN:1540-9538
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The pathophysiology of drug-resistant pediatric epilepsy is unknown. Flow cytometric analysis of inflammatory leukocytes in resected brain tissues from 29 pediatric patients with genetic (focal cortical dysplasia) or acquired (encephalomalacia) epilepsy demonstrated significant brain infiltration of blood-borne inflammatory myeloid cells and memory CD4 and CD8 T cells. Significantly, proinflammatory (IL-17- and GM-CSF-producing) γδ T cells were concentrated in epileptogenic lesions, and their numbers positively correlated with disease severity. Conversely, numbers of regulatory T (T reg) cells inversely correlated with disease severity. Correspondingly, using the kainic acid model of status epilepticus, we show ameliorated seizure activity in both γδ T cell- and IL-17RA-deficient mice and in recipients of T reg cells, whereas T reg cell depletion heightened seizure severity. Moreover, both IL-17 and GM-CSF induced neuronal hyperexcitability in brain slice cultures. These studies support a major pathological role for peripherally derived innate and adaptive proinflammatory immune responses in the pathogenesis of intractable epilepsy and suggest testing of immunomodulatory therapies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:Publisher

  3 / 2924 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29208662
[Au] Autor:Deshmukh M; Patole S
[Ad] Address:Department of Neonatal Paediatrics, Fiona Stanley Hospital, Perth, Western Australia, Australia.
[Ti] Title:Antenatal corticosteroids in impending preterm deliveries before 25 weeks' gestation.
[So] Source:Arch Dis Child Fetal Neonatal Ed;103(2):F173-F176, 2018 Mar.
[Is] ISSN:1468-2052
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Antenatal corticosteroid (ANC) use before 25 weeks' gestation is controversial. Our previous systematic review (eight observational studies, n=10 109) showed that ANC exposure was associated with significantly reduced mortality and severe intraventricular haemorrhage (IVH)/periventricular leukomalacia (PVL) in neonates born <25 weeks. We update our review by adding data (n=3334) from a recent study. We used Cochrane methodology and summarised the results using GRADE (The Grading of Recommendations Assessment, Development and Evaluation) guidelines. Nine high-quality observational studies were included. Meta-analysis (random effects model) showed reduced mortality (n=13 443; OR=0.48 (95% CI 0.42 to 0.55) P<0.00001; level of evidence (LOE): moderate) and IVH or PVL (n=8418; OR=0.70 (95% CI 0.63 to 0.79), P<0.00001; LOE: moderate) in neonates born <25 weeks exposed to ANC. There was no difference in necrotising enterocolitis (NEC) ≥stage II (n=8737; OR=1.01 (95% CI 0.84 to 1.22), P=0.89; LOE: low); incidence of chronic lung disease (CLD) was higher (n=7983; OR=1.32 (95% CI 1.04 to 1.67), P=0.02; LOE: low) in ANC group. Composite outcomes of death/major morbidities (eg, severe IVH, NEC, CLD) were improved after ANC exposure.
[Mh] MeSH terms primary: Adrenal Cortex Hormones/administration & dosage
Cerebral Intraventricular Hemorrhage/mortality
Cerebral Intraventricular Hemorrhage/prevention & control
Leukomalacia, Periventricular/mortality
Leukomalacia, Periventricular/prevention & control
[Mh] MeSH terms secundary: Enterocolitis, Necrotizing/mortality
Enterocolitis, Necrotizing/prevention & control
Gestational Age
Humans
Infant, Newborn
Lung Diseases/mortality
Lung Diseases/prevention & control
Observational Studies as Topic
[Pt] Publication type:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Name of substance:0 (Adrenal Cortex Hormones)
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:171207
[St] Status:MEDLINE
[do] DOI:10.1136/archdischild-2017-313840

  4 / 2924 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29422364
[Au] Autor:Ferenczi EA; Saadi A; Bhattacharyya S; Berkowitz AL
[Ad] Address:Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address: eferenczi@partners.org.
[Ti] Title:Glioblastoma arising within sites of encephalomalacia from cerebrovascular insult: two cases and a review of the literature.
[So] Source:J Clin Neurosci;, 2018 Feb 05.
[Is] ISSN:1532-2653
[Cp] Country of publication:Scotland
[La] Language:eng
[Ab] Abstract:Glioblastoma is the most common primary parenchymal brain malignancy, with median survival of less than one year. While there are likely multiple predisposing genetic and environmental factors in glioblastoma formation, chronic inflammation resulting from non-traumatic vascular brain injury is one proposed risk factor for oncogenesis. Here, we report two instances of glioblastoma arising within areas of encephalomalacia caused by remote vascular insults (one following aneurysmal subarachnoid hemorrhage and one following ischemic infarction), review the literature associating glioblastoma with prior brain injury, and discuss potential mechanisms for malignant transformation in injured brain tissue.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180209
[Lr] Last revision date:180209
[St] Status:Publisher

  5 / 2924 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 29319242
[Au] Autor:Koshy JM; Mohan S; Deodhar D; John M; Oberoi A; Pannu A
[Ad] Address:Associate Professor, Department of Medicine.
[Ti] Title:Clinical Diversity of CNS Cryptococcosis.
[So] Source:J Assoc Physicians India;65(10):15-19, 2017 Oct.
[Is] ISSN:0004-5772
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Background: Though cryptococcal meningitis (CM) is recognized as a disease of the immunocompromised, studies have implicated that it also affect immunocompetent patients. Methodology: This was a cross sectional study conducted in the Department of Medicine of a tertiary teaching institution in North India. All the patients diagnosed with CM on the basis of detection of cryptococcal antigen or the presence of capsulated budding yeast cells on India ink preparation, from April 2009 to March2015 were included in the study. Demographical profile, clinical presentation, predisposing factors, CSFcharacteristics, imaging abnormalities and in patient outcome were noted and analyzed. Results: Among the 40 patients diagnosed with CM, 62.5% of them were males. Patients who were immunocompetent constituted 20%, those with predisposing factors other than HIV were 25% and55% had HIV infection (initial presentation in 59%). Mean age of presentation was 44.75 15.58 years. Mean duration of symptoms in all three groups varied from few days to 4-5 weeks. Clinical presentations included fever (16), headache (14), altered sensorium (16), seizures (5), paraparesis (4), hemiparesis (2), lateral rectus palsy (3), VII nerve palsy (2), bilateral vision loss with ptosis (1) and ataxia (1). Neck stiffness was present in 50% patients of immunocompetent group, 45.45% of HIV patients and none in the 3rd group. Acellular CSF (37.5%) was not unusual. Mean CSF white cell count in HIV patients, in other immunocompromised patients and immunocompetent patients were 100 158.53, 36.88 92.43 and 32.5 62.05 /mm3 respectively which was predominantly lymphocytic. Mean CSF protein were 136.73 139.82, 62.67 51.11 and 152.29 218.24 g/dl in these groups. Abnormalities detected on imaging included, meningeal enhancement, encephalomalacia, infarct, cerebellitis, hydrocephalus, cord hyper intensities and cervical spine intramedullary lesion. Mortality rate in CM patients was 20%. On mortality analysis, death was mostly attributed to the primary disease. Conclusion: Clinical presentation of CM in both immunocompetent and immunocompromised patients was similar. Though previous studies noted less inflammation in immunocompromised patients, in this series it was noted that both immunocompromised and immunocompetent patients mounted similar inflammatory response. Since the presentation of CM is variable, all cases of meningitis should be screened for the same.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180110
[Lr] Last revision date:180110
[St] Status:In-Data-Review

  6 / 2924 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29250724
[Au] Autor:Tulloch I; Palmer S; Scott R; Lozsadi D; Martin AJ
[Ad] Address:Neurosurgical Department, Atkinson Morley Wing, St George's Hospital, London, UK. isabeltulloch@doctors.org.uk.
[Ti] Title:Cognitive improvement following repair of a basal encephalocele.
[So] Source:Acta Neurochir (Wien);, 2017 Dec 17.
[Is] ISSN:0942-0940
[Cp] Country of publication:Austria
[La] Language:eng
[Ab] Abstract:We report the case of a 55-year-old woman presenting with progressive memory impairment secondary to a transsphenoidal encephalocele involving her dominant medial temporal lobe. Her clinical deterioration was accompanied by radiological progression in the encephalocele's size and associated encephalomalacia. Through a temporal craniotomy, her encephalocele was resected and the defect closed. Baseline neuropsychological assessment indicated global cognitive impairment, but post-operatively, she reported improved memory and concentration. Standardized assessment reflected an improvement in perceptual skills and an associated improved recall of a complex figure. This is the first case report to date of a patient's memory improving following treatment of a basal encephalocele.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171218
[Lr] Last revision date:171218
[St] Status:Publisher
[do] DOI:10.1007/s00701-017-3422-7

  7 / 2924 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29192634
[Au] Autor:Ezeala-Adikaibe AB; Ohaegbulam SC; Ndubuisi CA
[Ad] Address:Department of Neurosurgery, Neurosurgery Unit, Memfys Hospital for Neurosurgery; Department of Medicine, University of Teaching Hospital, Enugu, Nigeria.
[Ti] Title:The Pattern of significant lesions found in computerized tomography scan of recurrent seizure patients at a center in Enugu, Nigeria.
[So] Source:Niger J Clin Pract;20(10):1289-1293, 2017 Oct.
[Is] ISSN:1119-3077
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Seizures are common reasons for neurologic consultations and investigations. In the absence of magnetic resonance imaging, computerized tomography scanning of the brain is a reliable and cheaper alternative. Little is known about the pattern of brain lesions in patients with recurrent seizures in Nigeria. OBJECTIVES: To determine the pattern of significant intracerebral lesions in patients presenting with recurrent seizures in a tertiary hospital in Enugu. METHODS: All the medical and computer tomography records of patients with a clinical diagnosis of recurrent seizures were reviewed. The study duration was 11 years (January 2003 to December 2013). Relevant data were obtained and statistical analysis was done using SPSS version 19 and GraphPad Prism 6. RESULTS: The diagnostic yield of CT was 55.1%. Twenty (9.3%) individuals had two lesions each. The significant findings were tumors (20.4%), encephalomalacia (18.9%) and strokes (7.7% (ischemic stroke, 4.1%, intracerebral hemorrhage, 3.1%, subarachnoid hemorrhage/intraventricular hemorrhage, 0.5%). Hydrocephalus (HCP) was found in 18 (9.2%) cases, and 30% of them occurred together with other lesions. The diagnostic yield increased with age reaching 84.4% from the age of 60 years. Only patients with encephalomalacia were statistically older than those with normal imaging. CONCLUSION: Computed tomography scan has a high diagnostic yield, especially in elderly patients with recurrent generalized seizures. Brain tumors, encephalomalacia, and HCP are most common causes of recurrent seizures in the adults.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171201
[Lr] Last revision date:171201
[St] Status:In-Process
[do] DOI:10.4103/njcp.njcp_215_16

  8 / 2924 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29156559
[Au] Autor:Comitato R; Ambra R; Virgili F
[Ad] Address:Council for Agricultural Research and Economics, Research Centre for Food and Nutrition (CREA-AN) via Ardeatina 546, 00178 Rome, Italy. raffaella.comitato@crea.gov.it.
[Ti] Title:Tocotrienols: A Family of Molecules with Specific Biological Activities.
[So] Source:Antioxidants (Basel);6(4), 2017 Nov 18.
[Is] ISSN:2076-3921
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Vitamin E is a generic term frequently used to group together eight different molecules, namely: α-, -, γ- and δ-tocopherol and the corresponding tocotrienols. The term tocopherol and eventually Vitamin E and its related activity was originally based on the capacity of countering foetal re-absorption in deficient rodents or the development of encephalomalacia in chickens. In humans, Vitamin E activity is generally considered to be solely related to the antioxidant properties of the tocolic chemical structure. In recent years, several reports have shown that specific activities exist for each different tocotrienol form. In this short review, tocotrienol ability to inhibit cancer cell growth and induce apoptosis thanks to specific mechanisms, not shared by tocopherols, such as the binding to Estrogen Receptor- (ER) and the triggering of endoplasmic reticulum (EndoR) stress will be described. The neuroprotective activity will also be presented and discussed. We propose that available studies strongly indicate that specific forms of tocotrienols have a distinct mechanism and biological activity, significantly different from tocopherol and more specifically from α-tocopherol. We therefore suggest not pooling them together within the broad term "Vitamin E" on solely the basis of their putative antioxidant properties. This option implies obvious consequences in the assessment of dietary Vitamin E adequacy and, probably more importantly, on the possibility of evaluating a separate biological variable, determinant in the relationship between diet and health.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1711
[Cu] Class update date: 171121
[Lr] Last revision date:171121
[St] Status:PubMed-not-MEDLINE

  9 / 2924 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29053073
[Au] Autor:Kerezoudis P; Grewal SS; Stead M; Lundstrom BN; Britton JW; Shin C; Cascino GD; Brinkmann BH; Worrell GA; Van Gompel JJ
[Ad] Address:Departments of 1 Neurosurgery and.
[Ti] Title:Chronic subthreshold cortical stimulation for adult drug-resistant focal epilepsy: safety, feasibility, and technique.
[So] Source:J Neurosurg;:1-11, 2017 Oct 20.
[Is] ISSN:1933-0693
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE Epilepsy surgery is effective for lesional epilepsy, but it can be associated with significant morbidity when seizures originate from eloquent cortex that is resected. Here, the objective was to describe chronic subthreshold cortical stimulation and evaluate its early surgical safety profile in adult patients with epilepsy originating from seizure foci in cortex that is not amenable to resection. METHODS Adult patients with focal drug-resistant epilepsy underwent intracranial electroencephalography monitoring for evaluation of resection. Those with seizure foci in eloquent cortex were not candidates for resection and were offered a short therapeutic trial of continuous subthreshold cortical stimulation via intracranial monitoring electrodes. After a successful trial, electrodes were explanted and permanent stimulation hardware was implanted. RESULTS Ten patients (6 males) who underwent chronic subthreshold cortical stimulation between 2014 and 2016 were included. Based on radiographic imaging, intracranial pathologies included cortical dysplasia (n = 3), encephalomalacia (n = 3), cortical tubers (n = 1), Rasmussen encephalitis (n = 1), and linear migrational anomaly (n = 1). The duration of intracranial monitoring ranged from 3 to 20 days. All patients experienced an uneventful postoperative course and were discharged home with a median length of stay of 10 days. No postoperative surgical complications developed (median follow-up length 7.7 months). Seizure severity and seizure frequency improved in all patients. CONCLUSIONS The authors' institutional experience with this small group shows that chronic subthreshold cortical stimulation can be safely and effectively performed in appropriately selected patients without postoperative complications. Future investigation will provide further insight to recently published results regarding mechanism and efficacy of this novel and promising intervention.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171020
[Lr] Last revision date:171020
[St] Status:Publisher
[do] DOI:10.3171/2017.5.JNS163134

  10 / 2924 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 28931047
[Au] Autor:Huang J; Zhang L; Kang B; Zhu T; Li Y; Zhao F; Qu Y; Mu D
[Ad] Address:Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
[Ti] Title:Association between perinatal hypoxic-ischemia and periventricular leukomalacia in preterm infants: A systematic review and meta-analysis.
[So] Source:PLoS One;12(9):e0184993, 2017.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Although investigators have implicated hypoxic-ischemia (HI) as a potential cause of periventricular leukomalacia (PVL), the role of clinical risk factors or markers for HI in the development of PVL remains controversial. The aim of this study was to identify perinatal HI-related factors associated with PVL. METHOD: The PubMed, EMBASE, and Cochrane Library databases were searched. The last search was performed on January 2017. Summary effect estimates (pooled odds ratios [ORs]) were calculated for each risk factor using fixed or random effects models with tests for heterogeneity and publication bias. RESULTS: Fifteen studies with a total of 12,851 participants were included in this meta-analysis, and 14 potential risk factors were analyzed. The pooled results showed that mothers with oligohydramnios (OR, 1.55; 95% confidence interval [CI], 1.05 to 2.30), preterm infants with acidemia (OR, 1.87; 95% CI, 1.18 to 2.97), 1-minute Apgar score <7 (OR 2.69; 95% CI, 1.13 to 6.41), 5-minute Apgar score <7 (OR, 1.89; 95% CI, 1.39 to 2.56), apnea (OR, 1.76; 95% CI, 1.07 to 2.90), respiratory distress syndrome (OR, 1.46; 95% CI, 1.04 to 2.03), and seizures (OR, 4.60; 95% CI, 2.84 to 7.46) were associated with increased risk of PVL. CONCLUSION: This study identified perinatal HI-related risk factors for the development of PVL in preterm infants. Future large-scale prospective clinical studies are required to validate and extend these findings.
[Mh] MeSH terms primary: Hypoxia-Ischemia, Brain/complications
Infant, Premature, Diseases/etiology
Leukomalacia, Periventricular/etiology
[Mh] MeSH terms secundary: Female
Humans
Infant, Newborn
Infant, Premature
Pregnancy
Risk Factors
[Pt] Publication type:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Entry month:1710
[Cu] Class update date: 171017
[Lr] Last revision date:171017
[Js] Journal subset:IM
[Da] Date of entry for processing:170921
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184993


page 1 of 293 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information