Database : MEDLINE
Search on : Endophthalmitis [Words]
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[PMID]: 29249044
[Au] Autor:Yoshida M; Kiyota N; Maruyama K; Kunikata H; Toyokawa M; Hagiwara S; Makimura K; Sato N; Taniuchi S; Nakazawa T
[Ad] Address:Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.
[Ti] Title:Endogenous Fusarium Endophthalmitis During Treatment for Acute Myeloid Leukemia, Successfully Treated with 25-Gauge Vitrectomy and Antifungal Medications.
[So] Source:Mycopathologia;183(2):451-457, 2018 Apr.
[Is] ISSN:1573-0832
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Endogenous fungal endophthalmitis (EFE) caused by disseminated fusariosis is a rare condition that generally has a poor outcome, even with intensive therapy. Here, we describe a case in which this type of EFE was diagnosed with vitreous sampling and was successfully treated with 25-gauge vitrectomy and antifungals, including liposomal amphotericin B and voriconazole. A 16-year-old male patient undergoing treatment for acute myeloid leukemia complained of eye pain and blurred vision in his right eye. Treatment was initiated for a vitreous opacity, possibly associated with herpetic retinitis, but the patient worsened and he was referred to us. Right-eye visual acuity was limited to light perception. We suspected endogenous endophthalmitis and performed 25-gauge vitrectomy with antibiotic perfusion of ceftazidime, vancomycin, and voriconazole. Vitreous culturing revealed the presence of Fusarium solani species complex, and enhanced computed tomography revealed disseminated fusariosis lesions in the lung, spleen, and the soft tissue of the left upper arm. The patient received antifungal treatment with liposomal amphotericin B and voriconazole, and these conditions were eliminated. Visual acuity recovered to 20/400 after additional vitrectomy for tractional retinal detachment and was maintained at this level during the 6-month follow-up period. The success of our treatment allowed the capture of optical coherence tomography images of the retina during fusarium-associated endogenous endophthalmitis and the follow-up period. Furthermore, this case showed that immediate vitrectomy for suspected EFE and intensive treatment can lead to a good clinical outcome.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process
[do] DOI:10.1007/s11046-017-0221-x

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[PMID]: 29515160
[Au] Autor:Kirstahler P; Bjerrum SS; Friis-Møller A; la Cour M; Aarestrup FM; Westh H; Pamp SJ
[Ad] Address:Research Group for Genomic Epidemiology, Technical University of Denmark, Kgs, Lyngby, Denmark.
[Ti] Title:Genomics-Based Identification of Microorganisms in Human Ocular Body Fluid.
[So] Source:Sci Rep;8(1):4126, 2018 Mar 07.
[Is] ISSN:2045-2322
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Advances in genomics have the potential to revolutionize clinical diagnostics. Here, we examine the microbiome of vitreous (intraocular body fluid) from patients who developed endophthalmitis following cataract surgery or intravitreal injection. Endophthalmitis is an inflammation of the intraocular cavity and can lead to a permanent loss of vision. As controls, we included vitreous from endophthalmitis-negative patients, balanced salt solution used during vitrectomy and DNA extraction blanks. We compared two DNA isolation procedures and found that an ultraclean production of reagents appeared to reduce background DNA in these low microbial biomass samples. We created a curated microbial genome database (>5700 genomes) and designed a metagenomics workflow with filtering steps to reduce DNA sequences originating from: (i) human hosts, (ii) ambiguousness/contaminants in public microbial reference genomes and (iii) the environment. Our metagenomic read classification revealed in nearly all cases the same microorganism that was determined in cultivation- and mass spectrometry-based analyses. For some patients, we identified the sequence type of the microorganism and antibiotic resistance genes through analyses of whole genome sequence (WGS) assemblies of isolates and metagenomic assemblies. Together, we conclude that genomics-based analyses of human ocular body fluid specimens can provide actionable information relevant to infectious disease management.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Data-Review
[do] DOI:10.1038/s41598-018-22416-4

  3 / 8582 MEDLINE  
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[PMID]: 29442030
[Au] Autor:Resende AFC; Pereira AF; Moreira TP; Patrício PSO; Fialho SL; Cunha GMF; Silva-Cunha A; Magalhães JT; Silva GR
[Ti] Title:PLGA Implants containing vancomycin and dexamethasone: development, characterization and bactericidal effects.
[So] Source:Pharmazie;71(8):439-446, 2016 08 01.
[Is] ISSN:0031-7144
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Post-operative endophthalmitis is an infection and an inflammation of the eye following a surgical procedure. Its treatment is based on drug injections into the eye. However, this treatment can lead to ocular complications. Intraocular implants could substitute the conventional therapy. Poly(lactic-co-glycolic acid) (PLGA) implants comprising on vancomycin and dexamethasone were evaluated as drug delivery system to treat endophthalmitis after cataract surgery. Implants were characterized by drug content uniformity, Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Wide Angle X-ray Scattering (WAXS), Scanning Electron Microscopy (SEM) and in vitro drug release. The bactericidal effect of vancomycin, eluted from the implants, was demonstrated against Staphylococcus aureus and Staphylococcus epidermidis. The drugs were uniformly distributed in the polymer. The analytical techniques revealed the chemical integrity of the drugs incorporated into the polymer and the modification of dexamethasone semi-crystalline nature. Drugs were controlled released from implants; and the eluted vancomycin showed bactericidal effects. In conclusion, PLGA implants containing vancomycin and dexamethasone may represent a therapeutic alternative to treat post-operative endophthalmitis.
[Mh] MeSH terms primary: Anti-Bacterial Agents/administration & dosage
Anti-Bacterial Agents/therapeutic use
Anti-Inflammatory Agents/administration & dosage
Anti-Inflammatory Agents/therapeutic use
Bacteria/drug effects
Dexamethasone/administration & dosage
Dexamethasone/therapeutic use
Drug Carriers
Lactic Acid
Polyglycolic Acid
Surgical Wound Infection/prevention & control
Vancomycin/administration & dosage
Vancomycin/therapeutic use
[Mh] MeSH terms secundary: Anti-Bacterial Agents/pharmacology
Drug Implants
Drug Liberation
Endophthalmitis/microbiology
Endophthalmitis/prevention & control
Humans
Microbial Sensitivity Tests
Ophthalmologic Surgical Procedures
Staphylococcus aureus/drug effects
Staphylococcus epidermidis/drug effects
Vancomycin/pharmacology
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Anti-Bacterial Agents); 0 (Anti-Inflammatory Agents); 0 (Drug Carriers); 0 (Drug Implants); 0 (polylactic acid-polyglycolic acid copolymer); 26009-03-0 (Polyglycolic Acid); 33X04XA5AT (Lactic Acid); 6Q205EH1VU (Vancomycin); 7S5I7G3JQL (Dexamethasone)
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[Js] Journal subset:IM
[Da] Date of entry for processing:180215
[St] Status:MEDLINE
[do] DOI:10.1691/ph.2016.6009

  4 / 8582 MEDLINE  
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[PMID]: 29303885
[Au] Autor:Palioura S; Sivaraman K; Joag M; Sise A; Batlle JF; Miller D; Espana EM; Amescua G; Yoo SH; Galor A; Karp CL
[Ad] Address:Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL.
[Ti] Title:Candida Endophthalmitis After Descemet Stripping Automated Endothelial Keratoplasty With Grafts From Both Eyes of a Donor With Possible Systemic Candidiasis.
[So] Source:Cornea;37(4):515-518, 2018 Apr.
[Is] ISSN:1536-4798
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To report 2 cases with late postoperative Candida albicans interface keratitis and endophthalmitis after Descemet stripping automated endothelial keratoplasty (DSAEK) with corneal grafts originating from a single donor with a history of presumed pulmonary candidiasis. METHODS: Two patients underwent uncomplicated DSAEK by 2 corneal surgeons at different surgery centers but with tissue from the same donor and were referred to the Bascom Palmer Eye Institute with multifocal infiltrates at the graft-host cornea interface 6 to 8 weeks later, and anterior chamber cultures that were positive for the same genetic strain of C. albicans. Immediate explantation of DSAEK lenticules and daily intracameral and instrastromal voriconazole and amphotericin injections failed to control the infection. Thus, both patients underwent therapeutic penetrating keratoplasty with intraocular lens explantation, pars plana vitrectomy, and serial postoperative intraocular antifungal injection. RESULTS: Both patients are doing well at 2 years postoperatively with best-corrected vision of 20/20 and 20/30+ with rigid gas permeable lenses. One patient required repeat optical penetrating keratoplasty and glaucoma tube implantation 1 year after the original surgery. Literature review reveals that donor lenticule explantation and intraocular antifungals are often inadequate to control fungal interface keratitis, and a therapeutic graft is commonly needed. CONCLUSIONS: Interface fungal keratitis and endophthalmitis due to infected donor corneal tissue is difficult to treat, and both recipients of grafts originating from the same donor are at risk of developing this challenging condition.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process
[do] DOI:10.1097/ICO.0000000000001333

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[PMID]: 29366591
[Au] Autor:Omari A; Abaloune Y; Hanafi Y; Riani M; Reda K; Aoubaaz A
[Ad] Address:Service d'ophtalmologie, hôpital militaire d'instruction Mohamed V, Hay Riad, Rabat, Maroc. Electronic address: dr.omari85@gmail.com.
[Ti] Title:Endophtalmie endogène compliquant un ulcère variqueux de la jambe : à propos d'un cas. [Endogenous endophthalmitis as a complication of varicose ulcer of the leg: Case report].
[So] Source:J Fr Ophtalmol;41(2):e85-e87, 2018 Feb.
[Is] ISSN:1773-0597
[Cp] Country of publication:France
[La] Language:fre
[Pt] Publication type:LETTER
[Em] Entry month:1801
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:In-Data-Review

  6 / 8582 MEDLINE  
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[PMID]: 29361927
[Au] Autor:Lin Z; Feng X; Zheng L; Moonasar N; Shen L; Wu R; Chen F
[Ad] Address:The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, No. 270 West College Road, Wenzhou, Zhejiang, 325027, China.
[Ti] Title:Incidence of endophthalmitis after 23-gauge pars plana vitrectomy.
[So] Source:BMC Ophthalmol;18(1):16, 2018 Jan 23.
[Is] ISSN:1471-2415
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Endophthalmitis is a rare but severe complication following PPV. The incidence of endophthalmitis varies between 20-gauge, 23-gauge, and 25-gauge incisions. The incidence and clinical features of endophthalmitis after 23-gauge PPV in an eye hospital in China was reported in this study. METHODS: Data of the eyes that underwent 23-gauge PPV from January 2011 to December 2014 at the Eye Hospital of Wenzhou Medical University was retrospectively collected. All the information was obtained from the electronic medical system. The exclusion criteria included: (1) preoperative diagnosis of endophthalmitis; (2) history of vitrectomy; (3) intraocular surgery within 6 months; (4) history of ocular penetrating trauma; (5) sutures for any of the 3 sclerotomy incisions; (6) patients with cancer, acquired immune deficiency syndrome, or taking drugs that may influence the immune system. The diagnosis of endophthalmitis was based on clinical characteristics and/or culture results from an operative sample. RESULTS: Three thousand nine hundred seventy nine eyes that underwent 23-gauge PPV surgery were included in this study. Among these eyes, 3 eyes developed endophthalmitis after surgery, giving an incidence of 0.075% (3/3979). The period in which endophthalmitis developed ranged from 1 to 5 days post-operation. The visual acuity decreased to hand motions or light perception postoperatively. The culture of aqueous and vitreous of the 2 eyes revealed Staphylococcus epidermidis and enterococcus faecalis respectively, however was negative for the third eye. All 3 eyes had a favorable response to the treatment of vitreous tap and intravitreal antibiotics injection. Two eyes gained visual acuity of 0.05 and 0.5, respectively at the final visit. CONCLUSIONS: Endophthalmitis is a rare but sight-threatening complication after 23-gauge pars plana vitrectomy. The peak duration of onset was within 5 days post-operation, with gram positive cocci being the common pathogenic organism.
[Mh] MeSH terms primary: Endophthalmitis/epidemiology
Eye Infections, Bacterial/epidemiology
Microsurgery/adverse effects
Retinal Diseases/surgery
Staphylococcal Infections/epidemiology
Surgical Wound Infection/epidemiology
Vitrectomy/adverse effects
[Mh] MeSH terms secundary: Adult
Aged
Aqueous Humor/microbiology
China/epidemiology
Endophthalmitis/diagnosis
Endophthalmitis/microbiology
Enterococcus faecalis/isolation & purification
Eye Infections, Bacterial/diagnosis
Eye Infections, Bacterial/microbiology
Female
Follow-Up Studies
Gram-Positive Bacterial Infections/diagnosis
Gram-Positive Bacterial Infections/epidemiology
Gram-Positive Bacterial Infections/microbiology
Humans
Incidence
Male
Microsurgery/instrumentation
Middle Aged
Retrospective Studies
Staphylococcal Infections/diagnosis
Staphylococcal Infections/microbiology
Staphylococcus epidermidis/isolation & purification
Surgical Wound Infection/microbiology
Ultrasonography
Visual Acuity
Vitrectomy/instrumentation
Vitreous Body/diagnostic imaging
Vitreous Body/microbiology
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:IM
[Da] Date of entry for processing:180125
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0678-5

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[PMID]: 29502618
[Au] Autor:Kindle T; Ferguson T; Ibach M; Greenwood M; Schweitzer J; Swan R; Sudhagoni RG; Berdahl JP
[Ad] Address:From the University of South Dakota Sanford School of Medicine (Kindle, Ferguson), the University of South Dakota School of Health Sciences (Sudhagoni), and Vance Thompson Vision (Ibach, Schweitzer, Berdahl), Sioux Falls, South Dakota, and Vance Thompson Vision (Greenwood), Fargo, North Dakota, and
[Ti] Title:Safety and efficacy of intravitreal injection of steroid and antibiotics in the setting of cataract surgery and trabecular microbypass stent.
[So] Source:J Cataract Refract Surg;44(1):56-62, 2018 Jan.
[Is] ISSN:1873-4502
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To evaluate the safety and efficacy of intravitreal administration of a steroid and antibiotics during cataract surgery compared with the typical postoperative topical regimen in preventing postoperative inflammation, pain, cystoid macular edema (CME), and endophthalmitis. SETTING: Private practice, Sioux Falls, South Dakota, USA. DESIGN: Retrospective case series. METHODS: The study group included eyes that had an intravitreal injection of triamcinolone-moxifloxacin-vancomycin at the time of cataract surgery with concomitant trabecular microbypass stent insertion. The control eyes had the same procedure but were prescribed topical antibiotics, steroids, and nonsteroidal antiinflammatory drugs postoperatively. Data were recorded preoperatively and 1 day, 1 week, 1 month, and 3 months postoperatively. Primary outcomes included the number of glaucoma medications, intraocular pressure (IOP), and IOP spikes of at least 15 mm Hg from baseline. RESULTS: There were 234 eyes in the study group and 249 eyes in the control group. The mean reduction in glaucoma medications was 0.24 drops in the study group and 0.80 drops in the control group 3 months postoperatively, whereas the mean IOP reduction was 2.59 mm Hg in the study group and 3.63 mm Hg in the control group. Pressure spikes were detected at 54 (5.7%) of 936 postoperative visits in the study group and at 37 (3.7%) of 996 visits in the control group. There were no cases of severe inflammation, CME, infection, or retinal detachments. CONCLUSIONS: Both groups had similar postoperative pressure reductions and incidence of IOP spikes. The results indicate that intravitreal injections of a steroid and antibiotics might be a safe option for glaucomatous eyes having cataract surgery with trabecular microbypass stent insertion.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:In-Data-Review

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[PMID]: 29217351
[Au] Autor:Relhan N; Forster RK; Flynn HW
[Ad] Address:Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.
[Ti] Title:Endophthalmitis: Then and Now.
[So] Source:Am J Ophthalmol;187:xx-xxvii, 2018 Mar.
[Is] ISSN:1879-1891
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To report historically evolving strategies (then and now) in prevention and management of endophthalmitis. DESIGN: A perspective on relevant topics in the prophylaxis and management of endophthalmitis. METHODS: This is an author-selected review of studies leading to changes in strategies for endophthalmitis management over the last 100 years. RESULTS: The current perspective discusses the trends and strategies over the past century. Historically, 3 endophthalmitis time-periods have existed and include the pre-antimicrobial era, the predominantly systemic antimicrobial era, and the current intravitreal antimicrobial era. The management of endophthalmitis from different etiologies, including endogenous, postinjection, post-cataract surgery, and other anterior segment-related (eg, post-penetrating keratoplasty), bleb-associated, glaucoma drainage device-associated, and open globe injury-associated, are discussed. Specific etiologies may predict most common microbial causes and may guide differing management strategies. Pars plana vitrectomy offers theoretical advantages but is generally reserved for patients with more advanced disease. CONCLUSIONS: Despite advances over the past 100 years, endophthalmitis is an important sight-threatening complication. Timely management with the appropriate use of antimicrobial agents may optimize visual outcomes.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:In-Data-Review

  9 / 8582 MEDLINE  
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[PMID]: 27772657
[Au] Autor:Balne PK; Agrawal R
[Ad] Address:National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore.
[Ti] Title:Re: Raman et al.: Five-year incidence and visual outcomes in postintravitreal injection endophthalmitis (Ophthalmology 2016;123:1162-4).
[So] Source:Ophthalmology;123(11):e67-e68, 2016 11.
[Is] ISSN:1549-4713
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:LETTER; COMMENT
[Em] Entry month:1610
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:In-Process

  10 / 8582 MEDLINE  
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[PMID]: 29326317
[Au] Autor:Bowen RC; Zhou AX; Bondalapati S; Lawyer TW; Snow KB; Evans PR; Bardsley T; McFarland M; Kliethermes M; Shi D; Mamalis CA; Greene T; Rudnisky CJ; Ambati BK
[Ad] Address:Department of Ophthalmology, University of Wisconsin, Madison, Wisconsin, USA.
[Ti] Title:Comparative analysis of the safety and efficacy of intracameral cefuroxime, moxifloxacin and vancomycin at the end of cataract surgery: a meta-analysis.
[So] Source:Br J Ophthalmol;, 2018 Jan 11.
[Is] ISSN:1468-2079
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Current practice methods are unclear as to the most safe and effective prophylactic pharmacotherapy and method of delivery to reduce postoperative endophthalmitis occurrence. METHODS: A systematic review and meta-analysis using Meta-analysis of Observational Studies in Epidemiology guidelines was performed to compare the efficacy of intracameral cefuroxime, moxifloxacin and vancomycin in preventing postphacoemulsification cataract surgery endophthalmitis. A safety analysis of intracameral antibiotics was concurrently performed. DATA SOURCES: BIOSIS Previews, CINAHL, ClinicalTrials.gov, Cochrane Library, Dissertations & Theses, EMBASE, PubMed, ScienceDirect and Scopus were searched from inception to January 2017. Data were pooled using a random effects model. All articles were individually reviewed and data were extracted by two independent reviewers. Funnel plot, risk of bias and quality of evidence analyses were performed. RESULTS: Seventeen studies with over 900 000 eyes were included, which favoured the use of intracameral antibiotics at the end of cataract surgery (OR 0.20; 95% CI 0.13 to 0.32; P<0.00001). The average weighted postoperative endophthalmitis incidence rates with intracameral cefuroxime, moxifloxacin and vancomycin were 0.0332%, 0.0153% and 0.0106%, respectively. Secondary analyses showed no difference in efficacy between intracameral plus topical antibiotics versus intracameral alone (P>0.3). Most studies had low to moderate risk of bias. The safety analysis showed minimal toxicity for moxifloxacin. Dosing errors led to the majority of toxicities with cefuroxime. Although rare, vancomycin was associated with toxic retinal events. CONCLUSION: Intracameral cefuroxime and moxifloxacin reduced endophthalmitis rates compared with controls with minimal or no toxicity events at standard doses. Additionally, intracameral antibiotics alone may be as effective as intracameral plus topical antibiotics.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180304
[Lr] Last revision date:180304
[St] Status:Publisher


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