Database : MEDLINE
Search on : Enterovirus and Infections [Words]
References found : 8833 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 884 go to page                         

  1 / 8833 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 29438743
[Au] Autor:Biscaro V; Piccinelli G; Gargiulo F; Ianiro G; Caruso A; Caccuri F; De Francesco MA
[Ad] Address:Institute of Microbiology, Department of Molecular and Translational Medicine, University of Brescia-Spedali Civili, Brescia, Italy.
[Ti] Title:Detection and molecular characterization of enteric viruses in children with acute gastroenteritis in Northern Italy.
[So] Source:Infect Genet Evol;60:35-41, 2018 Feb 10.
[Is] ISSN:1567-7257
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Enteric viral infections are a major concern for public health, and viral acute gastroenteritis is the principal cause of pediatric morbidity and mortality worldwide, mostly in developing countries. The purpose of this study was to determine the prevalence of different enteric viruses detected in a pediatric population with acute gastroenteritis symptoms, and to characterize the strains detected. Stools were collected from children, aged from 2 months to 15 years old, admitted to one of the main hospitals of Northern Italy, between November 2015 and October 2016. Stools were tested for nine enteric viruses (adenovirus, rotavirus A, norovirus, astrovirus, sapovirus, enterovirus, parechovirus, bocavirus and aichivirus) by molecular methods. Furthermore, rotavirus, norovirus and adenovirus were deeply characterized by nucleotide sequencing and phylogenetic analysis. A total of 151 out of 510 (29.6%) stools analyzed resulted positive for at least one of the enteric virus investigated. The most common virus detected was rotavirus A (53/151, 35.1%), followed by norovirus (39/151, 25.8%), adenovirus (35/151, 23.1%), sapovirus (9/151, 6%), enterovirus (5/151, 3.3%), astrovirus (5/151, 3.3%), parechovirus (4/151, 2.6%) and bocavirus (1/151, 0.6%). Aichi virus was not detected in any sample. Co-infections were detected in 12 out of 510 faecal samples (2.3%). These data improved the knowledge of the enteric viruses circulating in children in Northern Italy. In fact, besides rotavirus, adenovirus and norovirus, several viruses circulated across the whole year in the pediatric population object of this study. The introduction of specific viral diagnosis in our clinical setting will improve patient care by reducing unnecessary use of antibiotics addressing the right etiologic diagnosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  2 / 8833 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29391246
[Au] Autor:Chasqueira MJ; Paixão P; Rodrigues ML; Piedade C; Caires I; Palmeiro T; Botelho MA; Santos M; Curran M; Guiomar R; Pechirra P; Costa I; Papoila A; Alves M; Neuparth N
[Ad] Address:NOVA Medical School-Faculdade de Ciências Médicas, Campo Mártires da Pátria, 130, 1169-056 Lisboa, Portugal. Electronic address: mjchasqueira@nms.unl.pt.
[Ti] Title:Respiratory infections in elderly people: Viral role in a resident population of elderly care centers in Lisbon, winter 2013-2014.
[So] Source:Int J Infect Dis;69:1-7, 2018 Jan 31.
[Is] ISSN:1878-3511
[Cp] Country of publication:Canada
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The aim of this study was to analyze the etiology and clinical consequences of viral respiratory infections in 18 elderly care centers (ECC) in Lisbon, which housed a total of 1022 residents. METHODS: Nasopharyngeal swabs were collected whenever an elderly had symptoms of acute respiratory infections (ARI). PCR and RT-PCR were performed for influenza A/B, human parainfluenza virus 1-4, adenovirus, human metapneumovirus (HMPV), respiratory syncytial virus (RSV), rhinovirus, enterovirus, human coronavirus and human Bocavirus (HBoV). Array cards for atypical bacteria were also used in severe cases. RESULTS: In total, 188 episodes of ARI were reported, being rhinovirus the most frequently detected (n=53), followed by influenza A(H3) (n=19) and HBoV (n=14). Severe infections were reported in 19 patients, 11 of which were fatal, Legionela pneumophila, rhinovirus, HMPV and RSV associated with these fatalities. Nine influenza strains were analyzed, all antigenically dissimilar from vaccine strain 2013/14. "Age", "HMPV" and "Respiratory disease" showed an association with severe infection. CONCLUSIONS: In this study an etiologic agent could be found in 60% of the acute respiratory episodes. These data provides information about the circulating viruses in ECC and highlights the importance of searching both viruses and atypical bacteria in severe ARI.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  3 / 8833 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29523062
[Au] Autor:Nikonov OS; Chernykh ES; Garber MB; Nikonova EY
[Ad] Address:Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia. katya_nik@vega.protres.ru.
[Ti] Title:Enteroviruses: Classification, Diseases They Cause, and Approaches to Development of Antiviral Drugs.
[So] Source:Biochemistry (Mosc);82(13):1615-1631, 2017 Dec.
[Is] ISSN:1608-3040
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The genus Enterovirus combines a portion of small (+)ssRNA-containing viruses and is divided into 10 species of true enteroviruses and three species of rhinoviruses. These viruses are causative agents of the widest spectrum of severe and deadly epidemic diseases of higher vertebrates, including humans. Their ubiquitous distribution and high pathogenicity motivate active search to counteract enterovirus infections. There are no sufficiently effective drugs targeted against enteroviral diseases, thus treatment is reduced to supportive and symptomatic measures. This makes it extremely urgent to develop drugs that directly affect enteroviruses and hinder their development and spread in infected organisms. In this review, we cover the classification of enteroviruses, mention the most common enterovirus infections and their clinical manifestations, and consider the current state of development of anti-enteroviral drugs. One of the most promising targets for such antiviral drugs is the viral Internal Ribosome Entry Site (IRES). The classification of these elements of the viral mRNA translation system is also examined.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Process
[do] DOI:10.1134/S0006297917130041

  4 / 8833 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29362406
[Au] Autor:Wang J; Teng Z; Cui X; Li C; Pan H; Zheng Y; Mao S; Yang Y; Wu L; Guo X; Zhang X; Zhu Y
[Ad] Address:Department of Microbiology and Immunology, Institutes of Medical Science, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
[Ti] Title:Epidemiological and serological surveillance of hand-foot-and-mouth disease in Shanghai, China, 2012-2016.
[So] Source:Emerg Microbes Infect;7(1):8, 2018 Jan 24.
[Is] ISSN:2222-1751
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Aside from enterovirus 71 (EV71) and coxsackie virus A16 (CV-A16), viruses that are known to cause hand-foot-and-mouth disease (HFMD), epidemiological profiles of other enteroviruses that induce HFMD are limited. We collected 9949 laboratory surveillance HFMD cases and 1230 serum samples from infants and children in Shanghai from 2012-2016. Since 2013, CV-A6 has displaced EV71 and CV-A16 to become the predominant serotype. Interestingly, novel epidemiological patterns in EV71 and CV-A16 infections were observed, with one large peak in both 2012 and 2014, followed by two smaller peaks in the respective following years (2013 and 2015). Through sequencing, we found that C4a, B1b, D-Cluster-1 and B constituted the major subgenotypes of EV71, CV-A16, CV-A6 and CV-A10, respectively. Among healthy individuals, 50.49% and 54.23% had positive neutralising antibodies (NtAbs) against EV71 and CV-A16, respectively, indicating that EV71 and CV-A16 silent infections were common. These populations may be an important potential source of infection. The overall seropositive rate of EV71 NtAbs showed a fluctuating, markedly downward trend, indicating the potential risk of a future EV71 epidemic. High CV-A16 NtAb seroprevalence corroborated a documented CV-A16 'silent' epidemic. Children aged 1-5 years had the lowest EV71 NtAb seropositive rate, whereas those aged 1-2 years exhibited the lowest CV-A16 NtAb seropositive rate. This is the first comprehensive investigation of the epidemiology and aetiology, as well as the seroprevalence, of HFMD in Shanghai between 2012 and 2016. This study provides the latest insights into developing a more efficient HMFD vaccination programme.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process
[do] DOI:10.1038/s41426-017-0011-z

  5 / 8833 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29323107
[Au] Autor:Zhu R; Cheng T; Yin Z; Liu D; Xu L; Li Y; Wang W; Liu J; Que Y; Ye X; Tang Q; Zhao Q; Ge S; He S; Xia N
[Ad] Address:State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, 361102, China.
[Ti] Title:Serological survey of neutralizing antibodies to eight major enteroviruses among healthy population.
[So] Source:Emerg Microbes Infect;7(1):2, 2018 Jan 10.
[Is] ISSN:2222-1751
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Human enteroviruses (EVs) are the most common causative agents infecting human, causing many harmful diseases, such as hand, foot, and mouth disease (HFMD), herpangina (HA), myocarditis, encephalitis, and aseptic meningitis. EV-related diseases pose a serious worldwide threat to public health. To gain comprehensive insight into the seroepidemiology of major prevalent EVs in humans, we firstly performed a serological survey for neutralizing antibodies (nAbs) against Enterovirus A71 (EV-A71), Coxsackie virus A16 (CV-A16), Coxsackie virus A6 (CV-A6), Coxsackie virus A10 (CV-A10), Coxsackie virus B3 (CV-B3), Coxsackie virus B5 (CV-B5), Echovirus 25 (ECHO25), and Echovirus 30 (ECHO30) among the healthy population in Xiamen City in 2016, using micro-neutralization assay. A total of 515 subjects aged 5 months to 83 years were recruited by stratified random sampling. Most major human EVs are widely circulated in Xiamen City and usually infect infants and children. The overall seroprevalence of these eight EVs were ranged from 14.4% to 42.7%, and most of them increased with age and subsequently reached a plateau. The co-existence of nAbs against various EVs are common among people ≥ 7 years of age, due to the alternate infections or co-infections with different serotypes of EVs, while most children were negative for nAb against EVs, especially those < 1 year of age. This is the first report detailing the seroepidemiology of eight prevalent EVs in the same population, which provides scientific data supporting further studies on the improvement of EV-related disease prevention and control.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process
[do] DOI:10.1038/s41426-017-0003-z

  6 / 8833 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29323105
[Au] Autor:Zhang C; Zhang X; Zhang W; Dai W; Xie J; Ye L; Wang H; Chen H; Liu Q; Gong S; Geng L; Huang Z
[Ad] Address:Joint Center for Infection and Immunity, Guangzhou Institute of Pediatrics, Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 510623, Guangzhou, China.
[Ti] Title:Enterovirus D68 virus-like particles expressed in Pichia pastoris potently induce neutralizing antibody responses and confer protection against lethal viral infection in mice.
[So] Source:Emerg Microbes Infect;7(1):3, 2018 Jan 10.
[Is] ISSN:2222-1751
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Enterovirus D68 (EV-D68) has been increasingly associated with severe respiratory illness and neurological complications in children worldwide. However, no vaccine is currently available to prevent EV-D68 infection. In the present study, we investigated the possibility of developing a virus-like particle (VLP)-based EV-D68 vaccine. We found that co-expression of the P1 precursor and 3CD protease of EV-D68 in Pichia pastoris yeast resulted in the generation of EV-D68 VLPs, which were composed of processed VP0, VP1, and VP3 capsid proteins and were visualized as ~30 nm spherical particles. Mice immunized with these VLPs produced serum antibodies capable of specifically neutralizing EV-D68 infections in vitro. The in vivo protective efficacy of the EV-D68 VLP candidate vaccine was assessed in two challenge experiments. The first challenge experiment showed that neonatal mice born to the VLP-immunized dams were fully protected from lethal EV-D68 infection, whereas in the second experiment, passive transfer of anti-VLP sera was found to confer complete protection in the recipient mice. Collectively, these results demonstrate the proof-of-concept for VLP-based broadly effective EV-D68 vaccines.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process
[do] DOI:10.1038/s41426-017-0005-x

  7 / 8833 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 29292957
[Au] Autor:Bjerin O; Martín Muñoz D; Gerald C; Brytting M; Eriksson M
[Ad] Address:Karolinska sjukhuset - Solna, Sweden - pediatric neurology Solna, Sweden.
[Ti] Title:Misstänkt koppling mellan enterovirus D68 och akut slapp myelit hos svenska barn - Ansamling av fall under några veckor hösten 2016.
[So] Source:Lakartidningen;114, 2017 Nov 30.
[Is] ISSN:1652-7518
[Cp] Country of publication:Sweden
[La] Language:swe
[Ab] Abstract:Acute flaccid myelitis amongst Swedish children with a possible link to an outbreak of enterovirus D68 In september 2016 we had several cases of acute flaccid myelitis in our clinic. This coincided with an outbreak of enterovirus D68 (EV-D68) in Sweden during the same period. We describe three cases, of which one tested positive for EV-D68. Acute flaccid paralysis of one or more limbs preceded by an upper respiratory tract infection is highly suspicious of myelitis, and a viral cause must be included in the clinical work-up. In order to detect infection with EV-D68 in suspected acute flaccid myelitis, nasopharyngeal aspirate should be performed as early as possible. EV-D68 is normally not found in stool or cerebrospinal fluid tests but should be included in the clinical work-up. Treatment of acute flaccid myelitis is supportive only. There is no effective antiviral treatment and immunomodulating therapies show little effect. Persisting neurological deficits are common but lethal cases are rare.
[Mh] MeSH terms primary: Enterovirus Infections/complications
Myelitis/virology
Paralysis/virology
[Mh] MeSH terms secundary: Acute Disease
Child
Child, Preschool
Disease Outbreaks
Enterovirus D, Human/isolation & purification
Enterovirus Infections/epidemiology
Enterovirus Infections/therapy
Female
Humans
Magnetic Resonance Imaging
Male
Myelitis/diagnostic imaging
Myelitis/epidemiology
Myelitis/therapy
Paralysis/epidemiology
Paralysis/therapy
Sweden/epidemiology
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[Js] Journal subset:IM
[Da] Date of entry for processing:180103
[St] Status:MEDLINE

  8 / 8833 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29507246
[Au] Autor:Pons-Salort M; Oberste MS; Pallansch MA; Abedi GR; Takahashi S; Grenfell BT; Grassly NC
[Ad] Address:Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, United Kingdom; m.pons-salort@imperial.ac.uk.
[Ti] Title:The seasonality of nonpolio enteroviruses in the United States: Patterns and drivers.
[So] Source:Proc Natl Acad Sci U S A;, 2018 Mar 05.
[Is] ISSN:1091-6490
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Nonpolio enteroviruses are diverse and common viruses that can circulate year-round but tend to peak in summer. Although most infections are asymptomatic, they can result in a wide range of neurological and other diseases. Many serotypes circulate every year, and different serotypes predominate in different years, but the drivers of their geographical and temporal dynamics are not understood. We use national enterovirus surveillance data collected by the US Centers for Disease Control and Prevention during 1983-2013, as well as demographic and climatic data for the same period, to study the patterns and drivers of the seasonality of these infections. We find that the seasonal pattern of enterovirus cases is spatially structured in the United States and similar to that observed for historical prevaccination poliomyelitis (1931-1954). We identify latitudinal gradients for the amplitude and the timing of the peak of cases, meaning that those are more regularly distributed all year-round in the south and have a more pronounced peak that arrives later toward the north. The peak is estimated to occur between July and September across the United States, and 1 month earlier than that for historical poliomyelitis. Using mixed-effects models, we find that climate, but not demography, is likely to drive the seasonal pattern of enterovirus cases and that the dew point temperature alone explains ∼30% of the variation in the intensity of transmission. Our study contributes to a better understanding of the epidemiology of enteroviruses, demonstrates important similarities in their circulation dynamics with polioviruses, and identifies potential drivers of their seasonality.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:Publisher

  9 / 8833 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29458129
[Au] Autor:Li X; Huang Y; Sun M; Ji H; Dou H; Hu J; Yan Y; Wang X; Chen L
[Ad] Address:Central Laboratory, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China.
[Ti] Title:Honeysuckle-encoded microRNA2911 inhibits Enterovirus 71 replication via targeting VP1 gene.
[So] Source:Antiviral Res;152:117-123, 2018 Feb 16.
[Is] ISSN:1872-9096
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Enterovirus 71 (EV71) is the primary pathogen of hand-foot-and-mouth disease (HFMD) in children and virus infections are associated with severe neurological dysfunctions and even death. MIR2911 is a honeysuckle-encoded atypical microRNA with extreme stability. Here, we report that MIR2911 directly inhibits EV71 replication by targeting the VP1 gene. Bioinformatics prediction and luciferase reporter assay showed that MIR2911 could target the VP1 gene of EV71. Transfection experiments using synthetic MIR2911 and extracted RNA from HS decoction shown that each of these preparations was capable of inhibiting EV71 VP1 protein expression; however, these preparations did not impact EV71 mutants in which the MIR2911-binding sites were mutated. Furthermore, EV71 replication was increased by antagomirs against MIR2911 in the HS decoction, implying that MIR2911 was physiologically functional in controlling EV71 replication in vitro. These results indicated that, by targeting VP1 gene, MIR2911 may effectively inhibit EV71 replication. Our results also provide a potential novel strategy on the therapy and/or prevention of HFMD originating from EV71 virus infection.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180304
[Lr] Last revision date:180304
[St] Status:Publisher

  10 / 8833 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 29339251
[Au] Autor:Carta A; Sanna G; Briguglio I; Madeddu S; Vitale G; Piras S; Corona P; Peana AT; Laurini E; Fermeglia M; Pricl S; Serra A; Carta E; Loddo R; Giliberti G
[Ad] Address:Department of Chemistry and Pharmacy, University of Sassari, Via Muroni 23, 07100 Sassari, Italy. Electronic address: acarta@uniss.it.
[Ti] Title:Quinoxaline derivatives as new inhibitors of coxsackievirus B5.
[So] Source:Eur J Med Chem;145:559-569, 2018 Feb 10.
[Is] ISSN:1768-3254
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:Enteroviruses are among the most common and important human pathogens for which there are no specific antiviral agents approved by the US Food and Drug Administration so far. Particularly, coxsackievirus infections have a worldwide distribution and can cause many important diseases. We here report the synthesis of new 14 quinoxaline derivatives and the evaluation of their cytotoxicity and antiviral activity against representatives of ssRNA, dsRNA and dsDNA viruses. Promisingly, three compounds showed a very potent and selective antiviral activity against coxsackievirus B5, with EC in the sub-micromolar range (0.3-0.06 µM). A combination of experimental techniques (i.e. virucidal activity, time of drug addition and adsorption assays) and in silico modeling studies were further performed, aiming to understand the mode of action of the most active, selective and not cytotoxic compound, the ethyl 4-[(2,3-dimethoxyquinoxalin-6-yl)methylthio]benzoate (6).
[Mh] MeSH terms primary: Antiviral Agents/pharmacology
Enterovirus B, Human/drug effects
Quinoxalines/pharmacology
[Mh] MeSH terms secundary: Animals
Antiviral Agents/chemical synthesis
Antiviral Agents/chemistry
Cattle
Cell Line
Cell Survival/drug effects
Cricetinae
Dose-Response Relationship, Drug
Haplorhini
Humans
Microbial Sensitivity Tests
Models, Molecular
Molecular Structure
Quinoxalines/chemical synthesis
Quinoxalines/chemistry
Structure-Activity Relationship
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antiviral Agents); 0 (Quinoxalines)
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[Js] Journal subset:IM
[Da] Date of entry for processing:180118
[St] Status:MEDLINE


page 1 of 884 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information