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[PMID]: 29432913
[Au] Autor:Ren X; Liu W; Liu Y
[Ad] Address:Department of Infectious Diseases Medicine, Cangzhou Central Hospital, 16 Xinhua West Road, Cangzhou, 061001, China. Electronic address: renxiaojuan888@163.com.
[Ti] Title:Effects of fluconazole on the clinical outcome and immune response in fungal co-infected tuberculosis patients.
[So] Source:Microb Pathog;117:148-152, 2018 Feb 09.
[Is] ISSN:1096-1208
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:With overuse of the broad-spectrum antibiotics, the pulmonary fungal infection increasingly becomes the most common complication associated with senile pulmonary tuberculosis (TB) and attracts intensive attentions from clinicians. Here we presented the retrospective analysis of impact of fluconazole treatment on the clinical outcome and immune response in fungal co-infected tuberculosis patients. A randomized, double-blind, placebo-controlled trial of fluconazole (100 mg per day for consecutive weeks) in fungal-positive senile tuberculosis patients was conducted in our hospital. Peripheral eosinophil counts were computed by the automatic hematology analyzer. The secretory inflammatory cytokines interferon (IFN)-γ, tumor necrosis factor (TNF)-α and chemokines chemokine C-X-C motif ligand (CXCL)9, CXCL10, CXCL11 were determined with enzyme-linked immunosorbent assay kits. The peripheral T helper 1 cells (Th1) and regulatory T cells (Treg) population were analyzed by flow cytometry. None of significant difference in respect to baseline TB score was observed between placebo and fluconazole groups. Administration of fluconazole significantly stimulated eosinophils population and secretion of inflammatory cytokines IFN-γ and TNF-α. Simultaneously, the peripheral Th1% and chemokines including CXCL9, CSCL10, CXCL11 were markedly induced in response to fluconazole treatment. Fungal infection significantly affected host immunity during tuberculosis which was effectively reversed by fluconazole treatment.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  2 / 34821 MEDLINE  
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[PMID]: 29432856
[Au] Autor:Azevedo BC; Morel LJF; Carmona F; Cunha TM; Contini SHT; Delprete PG; Ramalho FS; Crevelin E; Bertoni BW; Frana SC; Borges MC; Pereira AMS
[Ad] Address:Departamento de Biotecnologia em Plantas Medicinais, Universidade de Ribeiro Preto, Av. Costbile Romano 2201, 14096-900 Ribeiro Preto, SP, Brazil.
[Ti] Title:Aqueous extracts from Uncaria tomentosa (Willd. ex Schult.) DC. reduce bronchial hyperresponsiveness and inflammation in a murine model of asthma.
[So] Source:J Ethnopharmacol;218:76-89, 2018 Feb 10.
[Is] ISSN:1872-7573
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:ETHNOPHARMACOLOGICAL RELEVANCE: Uncaria tomentosa (Willd. Ex Schult) DC is used by indigenous tribes in the Amazonian region of Central and South America to treat inflammation, allergies and asthma. The therapeutic properties of U. tomentosa have been attributed to the presence of tetracyclic and pentacyclic oxindole alkaloids and to phenolic acids. AIMS OF THE STUDY: To characterize aqueous bark extracts (ABE) and aqueous leaf extracts (ALE) of U. tomentosa and to compare their anti-inflammatory effects. MATERIALS AND METHODS: Constituents of the extracts were identified by ultra performance liquid chromatography-mass spectrometry. Anti-inflammatory activities were assessed in vitro by exposing lipopolysaccharide-stimulated macrophage cells (RAW264.7-Luc) to ABE, ALE and standard mitraphylline. In vivo assays were performed using a murine model of ovalbumin (OVA)-induced asthma. OVA-sensitized animals were treated with ABE or ALE while controls received dexamethasone or saline solution. Bronchial hyperresponsiveness, production of Th1 and Th2 cytokines, total and differential counts of inflammatory cells in the bronchoalveolar lavage (BAL) and lung tissue were determined. RESULTS: Mitraphylline, isomitraphylline, chlorogenic acid and quinic acid were detected in both extracts, while isorhyncophylline and rutin were detected only in ALE. ABE, ALE and mitraphylline inhibited the transcription of nuclear factor kappa-B in cell cultures, ALE and mitraphylline reduced the production of interleukin (IL)-6, and mitraphylline reduced production of tumor necrosis factor-alpha. Treatment with ABE and ALE at 50 and 200 mg kg , respectively, reduced respiratory elastance and tissue damping and elastance. ABE and ALE reduced the number of eosinophils in BAL, while ALE at 200 mg kg reduced the levels of IL-4 and IL-5 in the lung homogenate. Peribronchial inflammation was significantly reduced by treatment with ABE and ALE at 50 and 100 mg kg respectively. CONCLUSION: The results clarify for the first time the anti-inflammatory activity of U. tomentosa in a murine model of asthma. Although ABE and ALE exhibited distinct chemical compositions, both extracts inhibited the production of pro-inflammatory cytokines in vitro. In vivo assays revealed that ABE was more effective in treating asthmatic inflammation while ALE was more successful in controlling respiratory mechanics. Both extracts may have promising applications in the phytotherapy of allergic asthma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  3 / 34821 MEDLINE  
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[PMID]: 29524085
[Au] Autor:Han XJ; Su DH; Yi JY; Zou YW; Shi YL
[Ad] Address:Graduate School, Southern Medical University, Guangzhou, 510515, China. hanxiujing@sina.com.
[Ti] Title:A Literature Review of Blood-Disseminated P. marneffei Infection and a Case Study of this Infection in an HIV-Negative Child with Comorbid Eosinophilia.
[So] Source:Mycopathologia;, 2018 Mar 09.
[Is] ISSN:1573-0832
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: The typical manifestations of Penicillium marneffei (nowadays Talaromyces marneffei) infection in children without human immunodeficiency virus (HIV) remain unclear. The current work presents the case of a child without an underlying disease who was infected with P. marneffei comorbid with eosinophilia. CASE PRESENTATION: A 2-year-old male was infected with P. marneffei. A physical examination revealed a high-grade fever, ulcerated lesions in the oral mucosa, anemia, pruritic erythematous papules on the sac and thigh and watery diarrhea. A chest enhanced computed tomography scan showed multiple small, nodular, high-density shadows in the lungs, multiple lymphadenectasis in the hilum of the lungs and mediastinum, and liquid in the right pleural cavity. The patient's plasma was negative for HIV. Routine blood tests initially indicated that the patient had leucopenia; however, later tests indicated that he had leukocytosis. This peak was caused by a significant increase in eosinophils. The total IgE and specific allergen levels were normal. The stool was negative for parasite eggs. Aspergillus antigen (galactomannan, GM) levels were significantly increased and were present in the serum for a relatively long period. CONCLUSIONS: Eosinophilia can occur during P. marneffei infection, and this finding might provide additional information on the activity of this intracellular parasite. In addition, GM detection might be useful for monitoring the effect of antifungal treatments; however, this theory requires more data for verification.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1007/s11046-018-0255-8

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[PMID]: 29522851
[Au] Autor:Tanaka A; Allam VSRR; Simpson J; Tiberti N; Shiels J; To J; Lund M; Combes V; Weldon S; Taggart C; Dalton JP; Phipps S; Sukkar MB; Donnelly S
[Ad] Address:School of Life Sciences, Faculty of Science, The University of Technology Sydney, Ultimo, NSW, Australia.
[Ti] Title:The Parasitic 68-mer Peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity in experimental asthma.
[So] Source:J Allergy Clin Immunol;, 2018 Mar 06.
[Is] ISSN:1097-6825
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher

  5 / 34821 MEDLINE  
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[PMID]: 29484748
[Au] Autor:Peurala E; Tuominen M; Lyttyniemi E; Syrjnen S; Rautava J
[Ad] Address:Department of Oral Pathology and Oral Radiology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland.
[Ti] Title:Eosinophilia is a favorable prognostic marker for oral cavity and lip squamous cell carcinoma.
[So] Source:APMIS;126(3):201-207, 2018 Mar.
[Is] ISSN:1600-0463
[Cp] Country of publication:Denmark
[La] Language:eng
[Ab] Abstract:Eosinophils are frequently encountered with squamous cell carcinomas (SCC) and it has been proposed that tumor-associated tissue eosinophilia (TATE) could be of prognostic significance in oral SCC. The aim was to evaluate TATE in 83 oral cavity and 16 lip SCCs as well as the best possible use of TATE as a prognostic marker. The number of eosinophils was counted per high power fields (HPF, 400) in three different representative areas of the tumor and its stroma. The degree of TATE was analyzed in relation to clinicopathological features of tumors and patients' survival (follow-up mean 40.7months) using Fisher's exact test. TATE was detected in 58 (70%) oral and 8 (50%) lip SCC samples. The median number of eosinophils between oral and lip SCC was different (p=0.028) but TATE was similar per HPF (p=0.085). Totally, 6% of lip and 21% of oral SCC patients died during the follow-up. The patients with the higher TATE had significantly better survival than the patients with the lower TATE (p=0.0136). The best cut-off value predicting the survival was 4 eosinophils/HPF. TATE is a prognostic marker for oral and lip SCC: more than 4 eosinophils/HPF may predict more favorable prognosis.
[Mh] MeSH terms primary: Carcinoma, Squamous Cell/pathology
Eosinophilia/pathology
Eosinophils/pathology
Lip Neoplasms/pathology
Lip/pathology
[Mh] MeSH terms secundary: Adult
Aged
Aged, 80 and over
Alcohol Drinking/adverse effects
Biomarkers, Tumor/metabolism
Carcinoma, Squamous Cell/mortality
Disease-Free Survival
Eosinophils/cytology
Female
Humans
Leukocyte Count
Lip Neoplasms/mortality
Male
Middle Aged
Retrospective Studies
Smoking/adverse effects
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Biomarkers, Tumor)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180228
[St] Status:MEDLINE
[do] DOI:10.1111/apm.12809

  6 / 34821 MEDLINE  
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[PMID]: 29446280
[Au] Autor:Stepanenko LA; Savchenkov MF; Ilina SV; Anganova EV; Savilov ED
[Ti] Title:[An assessment of the immune status of the children population as a marker of technogenic pollution of the environment].
[So] Source:Gig Sanit;95(12):1129-33, 2016.
[Is] ISSN:0016-9900
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:This article describes results of the immunological study of school-aged children residing in cities with different levels of the technogenic air pollution. Children from cities with the highest level of the technogenic pollution had a high number of immature neutrophils (band cells) and eosinophils. The children living in these ecologically unfavorable areas have presented a reduction of T-cell antigen receptor CD3, CD4, CD8, CD20, CD16, CD95. This indicates to that both T-cell and B-cell immunity is suppressed. The decline of the phagocytic function in neutrophils indicates to the suppression of the nonspecific host defense mechanisms also.
[Mh] MeSH terms primary: Air Pollutants
B-Lymphocytes/immunology
Environmental Exposure
T-Lymphocytes/immunology
[Mh] MeSH terms secundary: Air Pollutants/adverse effects
Air Pollutants/analysis
Child
Environmental Exposure/adverse effects
Environmental Exposure/analysis
Environmental Exposure/prevention & control
Female
Humans
Immunocompetence/drug effects
Male
Monitoring, Immunologic/methods
Monitoring, Immunologic/statistics & numerical data
Population
Receptors, Antigen, T-Cell/analysis
School Health Services/organization & administration
School Health Services/statistics & numerical data
Siberia/epidemiology
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Air Pollutants); 0 (Receptors, Antigen, T-Cell)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180216
[St] Status:MEDLINE

  7 / 34821 MEDLINE  
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[PMID]: 29408878
[Au] Autor:Freundt-Revilla J; Heinrich F; Zoerner A; Gesell F; Beyerbach M; Shamir M; Oevermann A; Baumgrtner W; Tipold A
[Ad] Address:Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany.
[Ti] Title:The endocannabinoid system in canine Steroid-Responsive Meningitis-Arteritis and Intraspinal Spirocercosis.
[So] Source:PLoS One;13(2):e0187197, 2018.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Endocannabinoids (ECs) are involved in immunomodulation, neuroprotection and control of inflammation in the central nervous system (CNS). Activation of cannabinoid type 2 receptors (CB2) is known to diminish the release of pro-inflammatory factors and enhance the secretion of anti-inflammatory cytokines. Furthermore, the endocannabinoid 2-arachidonoyl glycerol (2-AG) has been proved to induce the migration of eosinophils in a CB2 receptor-dependent manner in peripheral blood and activate neutrophils independent of CB activation in humans. The aim of the current study was to investigate the influence of the endocannabinoid system in two different CNS inflammatory diseases of the dog, i.e. Steroid-Responsive Meningitis-Arteritis (SRMA) and Intraspinal Spirocercosis (IS). The two main endocannabinoids, anandamide (AEA) and 2-AG, were quantified by mass spectrometry in CSF and serum samples of dogs affected with Steroid- Responsive Meningitis-Arteritis in the acute phase (SRMA A), SRMA under treatment with prednisolone (SRMA Tr), intraspinal Spirocercosis and healthy dogs. Moreover, expression of the CB2 receptor was evaluated in inflammatory lesions of SRMA and IS and compared to healthy controls using immunohistochemistry (IHC). Dogs with SRMA A showed significantly higher concentrations of total AG and AEA in serum in comparison to healthy controls and in CSF compared to SRMA Tr (p<0.05). Furthermore, dogs with IS displayed the highest ECs concentrations in CSF, being significantly higher than in CSF samples of dogs with SRMA A (p<0.05). CSF samples that demonstrated an eosinophilic pleocytosis had the highest levels of ECs, exceeding those with neutrophilic pleocytosis, suggesting that ECs have a major effect on migration of eosinophils in the CSF. Furthermore, CB2 receptor expression was found in glial cells in the spinal cord of healthy dogs, whereas in dogs with SRMA and IS, CB2 was strongly expressed not only in glial cells but also on the cellular surface of infiltrating leukocytes (i.e. neutrophils, eosinophils, lymphocytes, plasma cells, and macrophages) at lesion sites. The present study revealed an upregulated endocannabinoid system in dogs with inflammatory CNS diseases, highlighting the endocannabinoid system as a potential target for treatment of inflammatory CNS diseases.
[Mh] MeSH terms primary: Arteritis/veterinary
Dog Diseases/physiopathology
Endocannabinoids/physiology
Meningitis/veterinary
Spinal Diseases/veterinary
Spirurida Infections/veterinary
[Mh] MeSH terms secundary: Animals
Arteritis/blood
Arteritis/cerebrospinal fluid
Arteritis/physiopathology
Chromatography, Liquid
Dog Diseases/blood
Dog Diseases/cerebrospinal fluid
Dogs
Endocannabinoids/blood
Endocannabinoids/cerebrospinal fluid
Mass Spectrometry
Meningitis/blood
Meningitis/cerebrospinal fluid
Meningitis/physiopathology
Spinal Diseases/blood
Spinal Diseases/cerebrospinal fluid
Spinal Diseases/physiopathology
Spirurida Infections/blood
Spirurida Infections/cerebrospinal fluid
Spirurida Infections/physiopathology
Tandem Mass Spectrometry
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Endocannabinoids)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180207
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0187197

  8 / 34821 MEDLINE  
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[PMID]: 29337391
[Au] Autor:Ishii T; Niikura Y; Kurata K; Muroi M; Tanamoto K; Nagase T; Sakaguchi M; Yamashita N
[Ad] Address:Department of Pharmacotherapy, Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo, Japan.
[Ti] Title:Time-dependent distinct roles of Toll-like receptor 4 in a house dust mite-induced asthma mouse model.
[So] Source:Scand J Immunol;87(3), 2018 Mar.
[Is] ISSN:1365-3083
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:House dust mites (HDMs) are a common source of allergens that trigger both allergen-specific and innate immune responses in humans. Here, we examined the effect of allergen concentration and the involvement of Toll-like receptor 4 (TLR4) in the process of sensitization to house dust mite allergens in an HDM extract-induced asthma mouse model. Intranasal administration of HDM extract induced an immunoglobulin E response and eosinophilic inflammation in a dose-dependent manner from 2.5 to 30g/dose. In TLR4-knockout mice, the infiltration of eosinophils and neutrophils into the lung was decreased compared with that in wild-type mice in the early phase of inflammation (total of three doses). However, in the late phase of inflammation (total of seven doses), eosinophil infiltration was significantly greater in TLR4-knockout mice than in wild-type mice. This suggests that the roles of TLR4 signaling are different between the early phase and the later phase of HDM allergen-induced inflammation. Thus, innate immune response through TLR4 regulated the response to HDM allergens, and the regulation was altered during the phase of inflammation.
[Mh] MeSH terms primary: Allergens/immunology
Antigens, Dermatophagoides/immunology
Asthma/immunology
Immunity, Innate/immunology
Pyroglyphidae/immunology
Toll-Like Receptor 4/immunology
[Mh] MeSH terms secundary: Airway Resistance/immunology
Animals
Bronchoalveolar Lavage Fluid/cytology
Disease Models, Animal
Eosinophils/pathology
Female
Immunization
Immunoglobulin E/immunology
Inflammation/immunology
Lung/cytology
Lung/immunology
Lung/pathology
Mice
Mice, Inbred C57BL
Mice, Knockout
Neutrophil Infiltration/immunology
Neutrophils/pathology
Signal Transduction/immunology
Toll-Like Receptor 4/genetics
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Allergens); 0 (Antigens, Dermatophagoides); 0 (Tlr4 protein, mouse); 0 (Toll-Like Receptor 4); 37341-29-0 (Immunoglobulin E)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180117
[St] Status:MEDLINE
[do] DOI:10.1111/sji.12641

  9 / 34821 MEDLINE  
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[PMID]: 29320813
[Au] Autor:Muoz-Carrillo JL; Muoz-Lpez JL; Muoz-Escobedo JJ; Maldonado-Tapia C; Gutirrez-Coronado O; Contreras-Cordero JF; Moreno-Garca MA
[Ad] Address:Laboratory of Cell Biology and Microbiology, Academic Unit of Biological Sciences, Autonomous University of Zacatecas, Zacatecas, Zacatecas, Mxico.
[Ti] Title:Therapeutic Effects of Resiniferatoxin Related with Immunological Responses for Intestinal Inflammation in Trichinellosis.
[So] Source:Korean J Parasitol;55(6):587-599, 2017 Dec.
[Is] ISSN:1738-0006
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:The immune response against Trichinella spiralis at the intestinal level depends on the CD4+ T cells, which can both suppress or promote the inflammatory response through the synthesis of diverse cytokines. During the intestinal phase, the immune response is mixed (Th1/Th2) with the initial predominance of the Th1 response and the subsequent domination of Th2 response, which favor the development of intestinal pathology. In this context, the glucocorticoids (GC) are the pharmacotherapy for the intestinal inflammatory response in trichinellosis. However, its therapeutic use is limited, since studies have shown that treatment with GC suppresses the host immune system, favoring T. spiralis infection. In the search for novel pharmacological strategies that inhibit the Th1 immune response (proinflammatory) and assist the host against T. spiralis infection, recent studies showed that resiniferatoxin (RTX) had anti-inflammatory activity, which decreased the serum levels of IL-12, INF-γ, IL-1, TNF-α, NO, and PGE2, as well the number of eosinophils in the blood, associated with decreased intestinal pathology and muscle parasite burden. These researches demonstrate that RTX is capable to inhibit the production of Th1 cytokines, contributing to the defense against T. spiralis infection, which places it as a new potential drug modulator of the immune response.
[Mh] MeSH terms primary: Diterpenes/pharmacology
Diterpenes/therapeutic use
Intestinal Diseases, Parasitic/drug therapy
Intestinal Diseases, Parasitic/immunology
Intestines/immunology
Trichinellosis/drug therapy
Trichinellosis/immunology
[Mh] MeSH terms secundary: Animals
CD4-Positive T-Lymphocytes/immunology
Cytokines/metabolism
Eosinophils/immunology
Humans
Inflammation Mediators/metabolism
Leukocyte Count
Th1 Cells/immunology
Th2 Cells/immunology
Trichinella spiralis/immunology
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Cytokines); 0 (Diterpenes); 0 (Inflammation Mediators); A5O6P1UL4I (resiniferatoxin)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180112
[St] Status:MEDLINE
[do] DOI:10.3347/kjp.2017.55.6.587

  10 / 34821 MEDLINE  
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[PMID]: 29522237
[Au] Autor:Figueiredo RT; Neves JS
[Ad] Address:Institute of Biomedical Sciences/Unit of Xerem, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
[Ti] Title:Eosinophils in fungal diseases: An overview.
[So] Source:J Leukoc Biol;, 2018 Mar 09.
[Is] ISSN:1938-3673
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Eosinophils are the prominent cells in asthma, allergic bronchopulmonary mycosis (ABPMs), and fungal-sensitization-associated asthma, but their roles in the immunopathology of these disorders are not well understood. Moreover, the immunological mechanisms underlying the molecular direct effector interactions between fungi and eosinophils are rare and not fully known. Here, we provide an overview of eosinophil contributions to allergic asthma and ABPMs. We also revise the major general mechanisms of fungal recognition by eosinophils and consider past and recent advances in our understanding of the molecular mechanisms associated with eosinophil innate effector responses to different fungal species relevant to ABPMs (Alternaria alternata, Candida albicans, and Aspergillus fumigatus). We further examine and speculate about the therapeutic relevance of these findings in fungus-associated allergic pulmonary diseases.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1002/JLB.4MR1117-473R


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