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Search on : Epiretinal and Membrane [Words]
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[PMID]: 29524030
[Au] Autor:Yenihayat F; Özkan B; Kasap M; Karabas VL; Güzel N; Akpinar G; Pirhan D
[Ad] Address:Department of Ophthalmology, Kocaeli State Hospital, 41100, Kocaeli, Turkey. fthynhyt@hotmail.com.
[Ti] Title:Vitreous IL-8 and VEGF levels in diabetic macular edema with or without subretinal fluid.
[So] Source:Int Ophthalmol;, 2018 Mar 09.
[Is] ISSN:1573-2630
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:PURPOSE: To determine the cytokine levels in vitreous samples of diabetic macular edema (DME) patients in comparison with nondiabetic patients, and to evaluate the effect of subretinal fluid on the cytokine levels of vitreous samples. METHODS: In this prospective case-control study, 11 eyes of 11 patients with DME and subretinal fluid, 11 eyes of 11 patients with DME without subretinal fluid, and 14 eyes of 14 patients who had undergone vitreoretinal surgery for the epiretinal membrane or a macular hole (control group) were evaluated. The blood glycated hemoglobin (HbA1c) level, vitreous vascular endothelial growth factor (VEGF), and interleukin-8 (IL-8) levels were determined. RESULTS: The vitreous VEGF level of patients in DME groups was significantly higher than the control group (p < 0.001) without significant difference between DME patients with and without subretinal fluid (p = 0.796). The vitreous IL-8 level of DME patients with subretinal fluid was significantly higher than both control (p = 0.002) and DME without subretinal fluid groups (p = 0.019). The blood HbA1c level was significantly higher in DME group with subretinal fluid than those without subretinal fluid (8.7 ± 1.32 and 7.1 ± 1.13%, respectively, p = 0.010). The only significant correlation was between vitreous VEGF level and blood HbA1c level in DME patients without subretinal fluid (r = 0.813, p = 0.002). CONCLUSIONS: IL-8 level in vitreous samples was higher in DME patients with subretinal fluid than those without subretinal fluid, suggesting that inflammation is an important factor in the progression of DME leading to the subretinal fluid formation in diabetic patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1007/s10792-018-0874-6

  2 / 3162 MEDLINE  
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[PMID]: 29393272
[Au] Autor:Tognetto D; De Giacinto C; D'Aloisio R; Papagno C; Pastore M; Zweyer M
[Ad] Address:Eye Clinic, University of Trieste, Trieste, Italy.
[Ti] Title:The Combination of Trypan Blue and Brilliant Blue G-Assisted Vitrectomy for Macular Pucker: Histopathological Findings.
[So] Source:Ophthalmologica;239(2-3):167-175, 2018.
[Is] ISSN:1423-0267
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:PURPOSE: To report on the combined use of trypan blue (TB) and brilliant blue G (BBG) for staining the epiretinal membrane (ERM) and internal limiting membrane (ILM) during vitrectomy and to describe the histopathological findings. METHODS: 10 surgical specimens were removed from 10 eyes with macular pucker during vitrectomy using a commercially available combination of TB and BBG for ERM and ILM staining and peeling. Specimens were evaluated using light and transmission electron microscopy. RESULTS: In all cases the combination of TB and BBG was useful for identifying and delineating ERM and ILM. No complications related to the use of the dye were observed during or after surgery. Glial cells were present in all specimens. Hyalocytes were observed in 6 cases and myofibroblasts in 3 of them. In 7 cases native vitreous collagen fibrils were found on the ILM, while in 5 specimens newly formed collagen was present. No clinical evidence of toxicity was observed during the 3-month follow-up. CONCLUSION: The combined use of TB and BBG appeared to be very useful intraoperatively to improve the visualization of ERM and ILM, thus facilitating their complete removal. Anatomical and histopathological findings demonstrated the safety and the efficacy of this vital dye.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Process
[do] DOI:10.1159/000485986

  3 / 3162 MEDLINE  
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[PMID]: 29298439
[Au] Autor:Anastasilakis K; Mourgela A; Kaniouras D; Moschou K
[Ti] Title:Tips, Tricks, and Advantages of 27-G Vitrectomy.
[So] Source:Ophthalmologica;239(2-3):176-177, 2018.
[Is] ISSN:1423-0267
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:PURPOSE: We present the advantages and technique variations of 27-G vitrectomy in a variety of surgical retina cases. METHODS: Patients with epiretinal membrane, retinal detachment, and proliferative diabetic retinopathy with vitreous hemorrhage and tractional detachments underwent 27-G vitrectomy. We present technique tricks, solutions to various problems and pitfalls, and the advantages of 27-G vitrectomy. RESULTS: Postoperative visual acuity improved significantly in all patients. Anatomical restoration was achieved in all cases. CONCLUSIONS: 27-G vitrectomy offers satisfactory outcomes in a wide variety of surgical retina cases and shows significant advantages in the postoperative course.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Process
[do] DOI:10.1159/000485519

  4 / 3162 MEDLINE  
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[PMID]: 29210008
[Au] Autor:Dell'Osso LF; Huang SS
[Ad] Address:Daroff-Dell'Osso Ocular Motility Laboratory, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, CASE Medical School, 10701, East Boulevard, Cleveland, OH, 44106, USA. lfd@case.edu.
[Ti] Title:Development and surgical removal of an epiretinal membrane in infantile nystagmus syndrome: a new type of oscillopsia.
[So] Source:Jpn J Ophthalmol;62(2):249-255, 2018 Mar.
[Is] ISSN:1613-2246
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:PURPOSE: To report and discuss a focal oscillopsia in a small area of the visual field produced by, and after the removal of, an epiretinal membrane (ERM) in an individual with infantile nystagmus syndrome (INS) since birth with no associated afferent visual deficits. STUDY DESIGN: A retrospective case report. METHODS: A chart review, including clinical and electrophysiological data. A 74 y/o man with INS and an epiretinal membrane was studied. Detailed studies of the retina post-removal of an epiretinal membrane, with consequent changes in best-corrected visual acuity (BCVA), and subjective oscillopsia compared to INS waveforms. OCT measurements and eye-movement data from digital video and scleral search-coil systems were used. RESULTS: The monocular ERM produced an unexpected focal area of torsional/vertical oscillopsia (noted 1 year prior to the ERM surgery) in the portion of the visual field that corresponded with distortions from the ERM. The remainder of the visual field, corresponding with normal healthy retina was unaffected and stable in all planes. Post-removal, BCVA improved with redevelopment of the foveal pit and focal oscillopsia became less noticeable but remained due to the retinal distortion. CONCLUSIONS: In patients with INS, complete oscillopsia suppression across the visual field requires undistorted vision. If a retinal area of visual distortion develops or results from retinal surgery, a symptomatic island of oscillopsia in one or more planes may result.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Process
[do] DOI:10.1007/s10384-017-0550-9

  5 / 3162 MEDLINE  
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[PMID]: 28745657
[Au] Autor:Akhundova LA; Kasimov EM
[Ad] Address:National Centre of Ophthalmology named after acad. Zarifa Aliyeva, 32/15 Javadkhan St., Baku, Azerbaijan, AZ 1114.
[Ti] Title:Khirurgicheskoe lechenie regmatogennykh otsloek setchatki s vysokim riskom razvitiia proliferativnoi vitreoretinopatii. [Surgical treatment of rhegmatogenous retinal detachments with high risk of proliferative vitreoretinopathy].
[So] Source:Vestn Oftalmol;133(3):51-57, 2017.
[Is] ISSN:0042-465X
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:AIM: to analyze the effect of internal limiting membrane (ILM) peeling in patients undergoing 23-gauge pars plana vitrectomy for the treatment of rhegmatogenous retinal detachment (RRD) with a high risk of proliferative vitreoretinopathy (PVR). MATERIAL AND METHODS: This was a prospective consecutive study of 231 eyes of 227 patients. All eyes underwent vitrectomy with silicone oil/gas tamponade for RRD with a high risk of PVR: in 42 eyes the ILM was peeled (group 1) and in the remaining 189 eyes - was not (group 2). The follow-up period was at least 3 months. RESULTS: In group 1, single-surgery anatomic success was achieved in 85.4% and definitive reattachment - in 95.2% of patients. In group 2, single-surgery anatomic success was achieved in 67.2% and definitive reattachment - in 89.4% of patients. None of the patients from group 1, who had their ILM peeled, developed epiretinal membrane. Final BCVA in groups 1 and 2 was 1.2±0.5 logMAR and 1.34±0.82 logMAR respectively (p=0.297). CONCLUSION: ILM peeling during vitrectomy in RRD patients at high risk of PVR provides high primary anatomic success rate.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process
[do] DOI:10.17116/oftalma2017133351-57

  6 / 3162 MEDLINE  
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[PMID]: 29290462
[Au] Autor:Lefevre A; Mathis T; Denis P; Kodjikian L
[Ad] Address:Service d'ophtlamologie, hôpital de la Croix-Rousse, 103, Grande-Rue de la Croix-Rousse, 69004 Lyon, France; Université Lyon-1, 8, avenue Rockefeller, 69003 Lyon, France.
[Ti] Title:Hémangioblastomes rétiniens : stratégie thérapeutique et suivi à long terme dans une cohorte rétrospective. [Retinal hemangioblastoma: Treatment strategy and long-term follow-up in a retrospective cohort].
[So] Source:J Fr Ophtalmol;41(2):164-169, 2018 Feb.
[Is] ISSN:1773-0597
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:INTRODUCTION: Retinal hemangioblastoma (RH) is a benign vascular tumor frequently associated with Von Hippel-Lindau disease (VHL). Tumor growth of RH may lead to deterioration of visual acuity, which can be difficult to treat. Early diagnosis may reduce complication rate and side effects of treatment. The present retrospective study evaluates the long-term follow-up and complications of RH treatment as a function of the therapeutic strategy used. MATERIALS AND METHODS: The study included patients with RH, followed at Croix Rousse university hospital, Lyon between 2010 and 2017. The following clinical features were recorded : age at diagnosis, presenting symptom, presence of VHL disease, treatments used, post-therapeutic complications and visual outcomes. RESULTS: Seven eyes of five patients were included in our study. Eighty percent of the patients had a mutation in the VHL gene. Four eyes (57%) were treated with laser photocoagulation and three eyes (43%) were treated with cryotherapy. The mean duration of follow-up was 35 months. One of the eyes treated using laser photocoagulation was complicated by an early epiretinal membrane with no visual consequence. Of the eyes treated by cryoapplication, one was complicated by a vitreous hemorrhage, and another by a rhegmatogenous retinal detachment, both of which resulted in a decrease in visual acuity. CONCLUSION: The long-term outcome for patients treated for RH was relatively good. Complications were strongly correlated with the initial size of the vascular tumor. Early diagnosis seems to improve visual outcomes. Ophthalmologic monitoring should be part of the systemic, multidisciplinary management.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:In-Process

  7 / 3162 MEDLINE  
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[PMID]: 29493707
[Au] Autor:Ansah JP; Koh V; de Korne DF; Bayer S; Pan C; Thiyagarajan J; Matchar DB; Lamoureux E; Quek D
[Ad] Address:Health Services and Systems Research, Duke-NUS Medical School, Singapore.
[Ti] Title:Projection of Eye Disease Burden in Singapore.
[So] Source:Ann Acad Med Singapore;47(1):13-28, 2018 Jan.
[Is] ISSN:0304-4602
[Cp] Country of publication:Singapore
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Singapore's ageing population is likely to see an increase in chronic eye conditions in the future. This study aimed to estimate the burden of eye diseases among resident Singaporeans stratified for age and ethnicity by 2040. MATERIALS AND METHODS: Prevalence data on myopia, epiretinal membrane (ERM), retinal vein occlusion (RVO), age macular degeneration (AMD), diabetic retinopathy (DR), cataract, glaucoma and refractive error (RE) by age cohorts and educational attainment from the Singapore Epidemiology of Eye Diseases (SEED) study were applied to population estimates from the Singapore population model. RESULTS: All eye conditions are projected to increase by 2040. Myopia and RE will remain the most prevalent condition, at 2.393 million (2.32 to 2.41 million) cases, representing a 58% increase from 2015. It is followed by cataract and ERM, with 1.33 million (1.31 to 1.35 million), representing an 81% increase, and 0.54 million (0.53 to 0.549 million) cases representing a 97% increase, respectively. Eye conditions that will see the greatest increase from 2015 to 2040 in the Chinese are: DR (112%), glaucoma (100%) and ERM (91.4%). For Malays, DR (154%), ERM (136%), and cataract (122%) cases are expected to increase the most while for Indians, ERM (112%), AMD (101%), and cataract (87%) are estimated to increase the most in the same period. CONCLUSION: Results indicate that the burden for all eye diseases is expected to increase significantly into the future, but at different rates. These projections can facilitate the planning efforts of both policymakers and healthcare providers in the development and provision of infrastructure and resources to adequately meet the eye care needs of the population. By stratifying for age and ethnicity, high risk groups may be identified and targeted interventions may be implemented.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[St] Status:In-Process

  8 / 3162 MEDLINE  
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[PMID]: 28470646
[Au] Autor:Seppey C; Wolfensberger TJ
[Ad] Address:Jules Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland.
[Ti] Title:Vitrektomie mit foveaaussparendem Membrana-limitans-interna-Peeling für myope Foveoschisis. Vitrectomy with Fovea-Sparing Internal Limiting Membrane Peeling for Myopic Foveoschisis.
[So] Source:Klin Monbl Augenheilkd;234(4):497-500, 2017 Apr.
[Is] ISSN:1439-3999
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Myopic foveoschisis is a rare form of a tractional maculopathy, which occurs in patients with elevated axial length. The contraction of the posterior hyaloid exerts tangential traction on the retinal surface with a subsequent continuous splitting of the retinal layers. Internal limiting membrane (ILM) peeling has been advocated in foveoschisis, but it has been associated with post-operative macular hole formation. We report on a modified surgical technique, which spares the fovea and may reduce the risk for macular hole formation. Retrospective analysis of 6 patients with myopic foveoschisis. The mean age was 53.8 ± 12.9 years (4M, 2F) and mean myopia was - 18.3 ± 6.5 Dpt. After a 23 g pars plana vitrectomy, the ILM was peeled on the entire macular surface, except in the foveal region lest the thin foveal structures be damaged. All patients received a gas tamponnade with 23 % SF6 and maintained a face down position for 5 days. Mean best-corrected pre-operative visual acuity was 0.87 ± 0.56 logMAR, which increased to 0.60 ± 0.40 logMAR at the end of follow-up. The retinal thickness, as measured by optical coherence tomography, decreased from 799 ± 352 micrometers to 318 ± 60 micrometers at the end of follow-up 7.8 ± 5.7 months. No case developed a macular hole. Vitrectomy with fovea sparing ILM peeling is a promising surgical technique, which results in an improved foveal anatomy and retinal function. Due to the sparing of the fovea, this surgical technique may reduce the risk of macular hole formation in the post-operative period.
[Mh] MeSH terms primary: Endotamponade/methods
Epiretinal Membrane/surgery
Fovea Centralis/pathology
Myopia/surgery
Organ Sparing Treatments/methods
Retinoschisis/surgery
Vitrectomy/methods
[Mh] MeSH terms secundary: Adult
Combined Modality Therapy/methods
Epiretinal Membrane/pathology
Female
Follow-Up Studies
Fovea Centralis/injuries
Humans
Male
Middle Aged
Myopia/diagnosis
Retinoschisis/diagnosis
Treatment Outcome
Visual Acuity
Vitrectomy/adverse effects
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[Js] Journal subset:IM
[Da] Date of entry for processing:170505
[St] Status:MEDLINE
[do] DOI:10.1055/s-0043-104429

  9 / 3162 MEDLINE  
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[PMID]: 28449695
[Au] Autor:Ness T; Boehringer D; Heinzelmann S
[Ad] Address:Eye Center, Medical Center, University of Freiburg, Faculty of Medicine, Killianstr. 5, 79106, Freiburg, Germany. thomas.ness@uniklinik-freiburg.de.
[Ti] Title:Intermediate uveitis: pattern of etiology, complications, treatment and outcome in a tertiary academic center.
[So] Source:Orphanet J Rare Dis;12(1):81, 2017 Apr 27.
[Is] ISSN:1750-1172
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Patients with intermediate uveitis (IU) represent a heterogenous group characterized by a wide spectrum of etiologies and regional differences. Aim of the study was to analyze the characteristics of patients with IU examined in an academic center in Germany. METHODS: We conducted a retrospective analysis of the clinical records of all patients with intermediate uveitis referred to the Eye Center, University of Freiburg from 2007 to 2014. Diagnosis followed the Standardization in Uveitis Nomenclature (SUN) criteria. Data analysis included: etiology of IU, demographics, complications, treatment and visual acuity. RESULTS: We identified 159 patients with intermediate uveitis during that period. Mean age at diagnosis was 35 years. Most are female (64%), and the mean duration of IU was 6.1 years (range 1 month - 35 years). Etiology of IU was idiopathic in 59%. Multiple sclerosis (MS) (20%) and sarcoidosis (10%) were frequent systemic causes of IU. Other etiologies including infectious diseases (tuberculosis, borreliosis) or immune-mediated conditions (eg, after vaccination) were present in 11%. The pattern of complications included macular edema (CME) (36%), cataract (24%), secondary glaucoma (7%), and epiretinal membrane formation (19%). Periphlebitis and optic neuritis were more frequent in conjunction with MS. Treatment comprised local and systemic steroids, immunosuppressive agents, biologics, and surgery. Best corrected visual acuity was better than 20/25 in 60% of the eyes after more than 10 years of follow-up. CONCLUSIONS: In our German academic center, most IU cases were idiopathic or associated with MS or sarcoidosis. In contrast to other countries, infectious cases were rare. Patients' overall visual prognosis is favorable even when the duration of IU has been long and and despite numerous complications.
[Mh] MeSH terms primary: Cataract/etiology
Glaucoma/etiology
Immunosuppressive Agents/therapeutic use
Multiple Sclerosis/complications
Sarcoidosis/complications
Uveitis, Intermediate
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Aged, 80 and over
Cataract/physiopathology
Child
Child, Preschool
Female
Glaucoma/physiopathology
Humans
Macular Edema/etiology
Macular Edema/physiopathology
Male
Middle Aged
Multiple Sclerosis/physiopathology
Retrospective Studies
Sarcoidosis/physiopathology
Steroids/therapeutic use
Treatment Outcome
Uveitis, Intermediate/complications
Uveitis, Intermediate/drug therapy
Uveitis, Intermediate/etiology
Uveitis, Intermediate/physiopathology
Visual Acuity/physiology
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Immunosuppressive Agents); 0 (Steroids)
[Em] Entry month:1802
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[Js] Journal subset:IM
[Da] Date of entry for processing:170429
[St] Status:MEDLINE
[do] DOI:10.1186/s13023-017-0638-9

  10 / 3162 MEDLINE  
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[PMID]: 29485834
[Au] Autor:Akaltun A; Eroz R; Dogan M; Bolu S; Onder HI; Onbas O; Kocabay K
[Ti] Title:Basal Cell Nevus (Gorlin) Syndrome with a Novel Heterozygous Deletion Frameshift Mutation (C.959delc, P.val322 Phe Fsx2) in the Ptch1 Gene Associated with Epiretinal Membrane, Odontogenic Keratocysts and without Skin Lesions and Falx Cerebri Calcification.
[So] Source:Genet Couns;27(2):259-62, 2016.
[Is] ISSN:1015-8146
[Cp] Country of publication:Switzerland
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:In-Process


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