Database : MEDLINE
Search on : Ergotism [Words]
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[PMID]: 29164358
[Au] Autor:de Assis Aquino Gondim F; Bastante P; Gondim WC; Filha JGH; Thomas FP
[Ad] Address:Department of Internal Medicine, Neurology Division, Universidade Federal do Ceará, Rua Professor Costa Mendes, 1608, CEP: 60.430-140, Fortaleza, CE, Brazil. gondimfranc@gmail.com.
[Ti] Title:Medical and neuropsychiatric phenomena depicted in two Spanish medieval texts of Marian miracles.
[So] Source:Neurol Sci;, 2017 Nov 21.
[Is] ISSN:1590-3478
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:In the history of Christianity, veneration of the Virgin Mary reached its greatest intensity in the XIII century. Her perceived impact on daily life was tremendous and not surprisingly this extended to the spheres of disease and healing. The purpose of this study is to compare the medical and neuropsychiatric findings in two XIII century Spanish texts of Marian miracles, both examples of the popular Catholicism (vs. official catholic doctrine). We analyzed the medical and neuropsychiatric events in the Cantigas de Santa Maria (Canticles of St. Mary, CSM), composed at the court of Alfonso X and the Milagros de Nuestra Señora (The Miracles of Our Lady, MNS), written by Gonzalo de Berceo. Among the 25 miracles reported in the MNS, medically relevant facts were addressed in 19 miracles with a total of 23 recorded events (including resurrection or escape from death in five) and demonic possession in three (one with witchcraft/deicide). The most common medical subjects were ergotism, obstetric-gynecological, sudden death, intellectual disability/illiteracy, encephalopathy/alcohol intoxication, suicide (with self-mutilation/castration), infanticide, infections, and absence of body decomposition after death. The 427 canticles in the CSM contain 270 medically relevant facts. Neuropsychiatric conditions were alluded to in 98 songs. Blindness and dystonia/weakness/deformities were the most common phenomena. Illuminations detailed many of the medical facts in the CSM, but not in the MNS. Medically relevant facts were described in both texts, but with more details in the CSM. Neurological conditions were more often described in the CSM, psychiatric conditions in the MNS.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171122
[Lr] Last revision date:171122
[St] Status:Publisher
[do] DOI:10.1007/s10072-017-3183-3

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[PMID]: 28674820
[Au] Autor:Bauer JI; Gross M; Cramer B; Wegner S; Hausmann H; Hamscher G; Usleber E
[Ad] Address:Dairy Sciences, Institute of Veterinary Food Science, Justus Liebig University Giessen, Ludwigstr. 21, 35390, Giessen, Germany. julia.bauer@vetmed.uni-giessen.de.
[Ti] Title:Detection of the tremorgenic mycotoxin paxilline and its desoxy analog in ergot of rye and barley: a new class of mycotoxins added to an old problem.
[So] Source:Anal Bioanal Chem;409(21):5101-5112, 2017 Aug.
[Is] ISSN:1618-2650
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:A newly developed enzyme immunoassay (EIA) for the detection of the tremorgenic indole-diterpene alkaloid paxilline (PAX) and closely related analogs was used to analyze ergot sclerotia collected from rye and barley fields. The mean EIA standard curve detection limit was 0.47 ± 0.14 ng/mL; relative cross-reactivity of toxin standard solutions was found for 11-hydroxy-paspaline (terpendole E, 1.1%) but not for lolitrem B or ergot alkaloids. Sclerotia from all fields were positive in the PAX-EIA at concentration levels of 620 ± 200 and 160 ± 37 µg/kg in ergot of rye and 130 ± 47 µg/kg in ergot of barley. Confirmatory analyses of sclerotia by liquid chromatography-tandem mass spectrometric detection identified PAX and its analog 13-desoxypaxilline. To the best of our knowledge, this is the first report on the natural occurrence of tremorgenic indole-diterpene alkaloid mycotoxins in ergot sclerotia from rye and barley. Along with details on the analytical methodology developed in this study, particularly PAX-antibody production, the relevance and implications of these findings for food and feed safety are discussed. Presence or absence of elevated levels of tremorgenic mycotoxins, along with the ergot alkaloids, would help in explaining the difference between the two distinct manifestations of historic ergotism, the convulsive and the gangrenous form. Further method development for paxilline and other tremorgenic mycotoxins in cereals used for food and feed is a prerequisite for a comprehensive risk assessment, which seems to be necessary in light of the findings reported here. Paxilline in ergot of rye.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170730
[Lr] Last revision date:170730
[St] Status:In-Data-Review
[do] DOI:10.1007/s00216-017-0455-y

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[PMID]: 28661928
[Au] Autor:Jatuworapruk K; Kattipathanapong T; Kasitanon N; Louthrenoo W
[Ad] Address:From the *Division of Rheumatology, Department of Internal Medicine, and †Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
[Ti] Title:Ergotism Masquerading Systemic Vasculitis.
[So] Source:J Clin Rheumatol;23(5):287-288, 2017 Aug.
[Is] ISSN:1536-7355
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1706
[Cu] Class update date: 170725
[Lr] Last revision date:170725
[St] Status:In-Data-Review
[do] DOI:10.1097/RHU.0000000000000523

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[PMID]: 28380578
[Au] Autor:Harlow BE; Goodman JP; Lynn BC; Flythe MD; Ji H; Aiken GE
[Ti] Title:Ruminal tryptophan-utilizing bacteria degrade ergovaline from tall fescue seed extract.
[So] Source:J Anim Sci;95(2):980-988, 2017 Feb.
[Is] ISSN:1525-3163
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The objectives of this study were to evaluate degradation of ergovaline in a tall fescue [ (Schreb.) Darbysh.] seed extract by rumen microbiota ex vivo and to identify specific bacteria capable of ergovaline degradation in vitro. Rumen cell suspensions were prepared by harvesting rumen fluid from fistulated wether goats ( = 3), straining, and differential centrifugation. Suspensions were dispensed into anaerobic tubes with added Trypticase with or without extract (∼10 µg kg ergovaline). Suspensions were incubated for 48 h at 39°C. Samples were collected at 0, 24, and 48 h for ergovaline analysis and enumeration of hyper-ammonia producing (HAB) and tryptophan-utilizing bacteria. Ergovaline values were analyzed by repeated measures using the mixed procedure of SAS. Enumeration data were log transformed for statistical analysis. When suspensions were incubated with extract, 11 to 15% of ergovaline disappearance was observed over 48 h ( = 0.02). After 24 h, suspensions with added extract had 10-fold less HAB than controls ( = 0.04), but treatments were similar by 48 h ( = 1.00). However, after 24 h and 48 h, suspensions with extract had 10-fold more tryptophan-utilizing bacteria ( < 0.01) that were later isolated and identified by their 16S RNA gene sequence as . The isolates and other known rumen pure cultures ( JB1, B159, HD4, B, F, MD1, SR) were evaluated for the ability to degrade ergovaline in vitro. Pure culture cell suspensions were incubated as described above and samples were taken at 0 and 48 h for ergovaline analysis. Data were analyzed using the ANOVA procedure of SAS. All HAB, including the isolates, tested degraded ergovaline (54 to 75%; < 0.05). B14 was also able to degrade ergovaline but to a lesser capacity (12%; < 0.05), but all other bacteria tested did not degrade ergovaline. The results of this study indicate which rumen bacteria may play an important role in ergovaline degradation and that microbiological strategies for controlling their activity could have ramifications for fescue toxicosis and other forms of ergotism in ruminants.
[Mh] MeSH terms primary: Bacteria/metabolism
Ergotamines/metabolism
Festuca/microbiology
Plant Extracts/chemistry
Seeds/chemistry
Tryptophan/metabolism
[Mh] MeSH terms secundary: Animals
Body Fluids/microbiology
Ergotamines/chemistry
Ergotism
Goats
Male
Rumen/microbiology
Seeds/microbiology
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Ergotamines); 0 (Plant Extracts); 059E2O9IV4 (ergovaline); 8DUH1N11BX (Tryptophan)
[Em] Entry month:1707
[Cu] Class update date: 171116
[Lr] Last revision date:171116
[Js] Journal subset:IM
[Da] Date of entry for processing:170406
[St] Status:MEDLINE
[do] DOI:10.2527/jas.2016.1128

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[PMID]: 27960261
[Au] Autor:Pitt JI; Miller JD
[Ad] Address:CSIRO Agriculture and Food , P.O. Box 52, North Ryde, New South Wales 1670, Australia.
[Ti] Title:A Concise History of Mycotoxin Research.
[So] Source:J Agric Food Chem;65(33):7021-7033, 2017 Aug 23.
[Is] ISSN:1520-5118
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Toxigenic fungi and mycotoxins entered human food supplies about the time when mankind first began to cultivate crops and to store them from one season to the next, perhaps 10,000 years ago. The storage of cereals probably initiated the transition by mankind from hunter-gatherer to cultivator, at the same time providing a vast new ecological niche for fungi pathogenic on grain crops or saprophytic on harvested grain, many of which produced mycotoxins. Grains have always been the major source of mycotoxins in the diet of man and his domestic animals. In the historical context, ergotism from Claviceps purpurea in rye has been known probably for more than 2000 years and caused the deaths of many thousands of people in Europe in the last millennium. Known in Japan since the 17th century, acute cardiac beriberi associated with the consumption of moldy rice was found to be due to citreoviridin produced by Penicillium citreonigrum. This toxin was believed to be only of historic importance until its reemergence in Brazil a few years ago. Other Penicillium toxins, including ochratoxin A, once considered to be a possible cause of Balkan endemic nephropathy, are treated in a historical context. The role of Fusarium toxins in human and animal health, especially T-2 toxin in alimentary toxic aleukia in Russia in the 1940s and fumonisins in equine leucoencephalomalasia, is set out in some detail. Finally, this paper documents the story of the research that led to our current understanding of the formation of aflatoxins in grains and nuts, due to the growth of Aspergillus flavus and its role, in synergy with the hepatitis B virus, in human liver cancer. During a period of climate change and greatly reduced crop diversity on a global basis, researchers tasked with monitoring the food system need to be aware of fungal toxins that might have been rare in their working careers that can reappear.
[Mh] MeSH terms primary: Crops, Agricultural/microbiology
Food Contamination/analysis
Mycotoxins/chemistry
Mycotoxins/metabolism
[Mh] MeSH terms secundary: Animals
Crops, Agricultural/chemistry
Crops, Agricultural/history
Fungi/genetics
Fungi/metabolism
History, 15th Century
History, 16th Century
History, 17th Century
History, 18th Century
History, 19th Century
History, 20th Century
History, 21st Century
History, Ancient
History, Medieval
Humans
Mycotoxins/history
[Pt] Publication type:HISTORICAL ARTICLE; JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Mycotoxins)
[Em] Entry month:1709
[Cu] Class update date: 170914
[Lr] Last revision date:170914
[Js] Journal subset:IM
[Da] Date of entry for processing:161215
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b04494

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[PMID]: 27546463
[Au] Autor:Navarro J; Curran A; Burgos J; Torrella A; Ocaña I; Falcó V; Crespo M; Ribera E
[Ad] Address:Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
[Ti] Title:Acute leg ischaemia in an HIV-infected patient receiving antiretroviral treatment.
[So] Source:Antivir Ther;22(1):89-90, 2017.
[Is] ISSN:2040-2058
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:An HIV-infected patient treated with tenofovir disoproxil fumarate/emtricitabine/elvitegravir/cobicistat developed severe acute ischaemia of both legs during a migraine episode. After being interrogated he admitted taking an ergotamine-containing preparation. Ergotism due to interaction between ergotics and cobicistat was diagnosed. We describe the first reported case of this interaction.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1608
[Cu] Class update date: 170310
[Lr] Last revision date:170310
[St] Status:In-Process
[do] DOI:10.3851/IMP3075

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[PMID]: 27448231
[Au] Autor:Hu D; Li M
[Ad] Address:College of Resource and Environment, Yuxi Normal University, Yuxi, 653100, P. R. China.
[Ti] Title:Three New Ergot Alkaloids from the Fruiting Bodies of Xylaria nigripes (Kl.) Sacc.
[So] Source:Chem Biodivers;14(1), 2017 Jan.
[Is] ISSN:1612-1880
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Three new ergot alkaloids, xylanigripones A - C (1 - 3) together with three known compounds, agroclavine (4), 8,9-didehydro-10-hydroxy-6,8-dimethylergolin (5), and (6S)-agroclavine N-oxide (6) were isolated from the fungus Xylaria nigripes (Kl.) Sacc. Their structures were elucidated by comprehensive spectroscopic analyses and high-resolution mass spectrometry as well as by comparison with the literature. The absolute configuration was determined by Density Functional Theory (DFT) calculation methods. In addition, all of the compounds were evaluated for bioactivity via a cytotoxicity assay, an acetylcholinesterase inhibition assay and a cholesterol ester transfer protein inhibition assay.
[Mh] MeSH terms primary: Ergot Alkaloids/isolation & purification
Fruiting Bodies, Fungal/chemistry
Xylariales/chemistry
[Mh] MeSH terms secundary: Ergot Alkaloids/pharmacology
Ergot Alkaloids/toxicity
Ergotism
Molecular Structure
Structure-Activity Relationship
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Ergot Alkaloids)
[Em] Entry month:1701
[Cu] Class update date: 170127
[Lr] Last revision date:170127
[Js] Journal subset:IM
[Da] Date of entry for processing:160723
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600173

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[PMID]: 28031641
[Au] Autor:Liegl CA; McGrath MA
[Ad] Address:Vascular Laboratory, St Vincent's Clinic, Darlinghurst, Sydney, New South Wales, Australia.
[Ti] Title:Ergotism: Case Report and Review of the Literature.
[So] Source:Int J Angiol;25(5):e8-e11, 2016 Dec.
[Is] ISSN:1061-1711
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:A case of ergotism is presented to illustrate the role of duplex ultrasonography in the diagnosis and management of this nonatherosclerotic cause of peripheral arterial disease. Historical aspects of ergotism are discussed together with reference to the relative vulnerability of different segments of the arterial circulation. Our case emphasizes the potential for complete reversibility of the vascular changes if recognized early.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1612
[Cu] Class update date: 170220
[Lr] Last revision date:170220
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1055/s-0034-1376397

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[PMID]: 27598502
[Au] Autor:Cifuentes M D; Blanco L S; Ramírez F C
[Ad] Address:Unidad de Urgencias, Hospital San Juan de Dios, Los Andes, Chile, dapacimu@gmail.com.
[Ti] Title:Ergotismo por uso simultáneo de ergotamínico y terapia antirretroviral: Report of one case. [Ergotism due to simultaneous use of ergot alkaloids and high activity antiretroviral therapy].
[So] Source:Rev Med Chil;144(6):807-12, 2016 Jun.
[Is] ISSN:0717-6163
[Cp] Country of publication:Chile
[La] Language:spa
[Ab] Abstract:High activity antiretroviral therapy may exacerbate the activity of ergot alkaloids due to an inhibition of cytochrome P450. We report a 57 years old female with AIDS treated with lamivudine, zidovudine, atazanavir, ritonavir and cotrimoxazole presenting with ischemic signs in the four limbs. There was acrocyanosis and weak radial and ulnar pulses. A family member referred that the patient used ergot alkaloids for headaches. An ergotism due to the simultaneous use of ergot alkaloids and antiretroviral therapy was suspected. The latter was discontinued and intravenous nitroglycerin, nifedipine and pentoxifyline were started with good results.
[Mh] MeSH terms primary: Antiretroviral Therapy, Highly Active
Ergot Alkaloids/adverse effects
Ergotism/etiology
[Mh] MeSH terms secundary: Ergotism/diagnosis
Ergotism/therapy
Female
HIV Infections/drug therapy
Humans
Middle Aged
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Ergot Alkaloids)
[Em] Entry month:1706
[Cu] Class update date: 170630
[Lr] Last revision date:170630
[Js] Journal subset:IM
[Da] Date of entry for processing:160907
[St] Status:MEDLINE

  10 / 566 MEDLINE  
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[PMID]: 27168210
[Au] Autor:Mundra LS; Maranda EL; Cortizo J; Augustynowicz A; Shareef S; Jimenez JJ
[Ad] Address:University of Miami, Miller School of Medicine, Department of Dermatology and Cutaneous Surgery, Miami, Florida.
[Ti] Title:The Salem Witch Trials-Bewitchment or Ergotism.
[So] Source:JAMA Dermatol;152(5):540, 2016 May 01.
[Is] ISSN:2168-6084
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1605
[Cu] Class update date: 160512
[Lr] Last revision date:160512
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.1001/jamadermatol.2015.4863


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