Database : MEDLINE
Search on : Euphorbiaceae [Words]
References found : 2054 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 206 go to page                         

  1 / 2054 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 29524564
[Au] Autor:Benabdelaziz I; Gómez-Ruiz S; Benkhaled M; Carralero S; Schenker P; Salm A; Gertsch J; Haba H
[Ad] Address:Laboratoire de Chimie et Chimie de l'Environnement (L.C.C.E.), Département de Chimie, Faculté des Sciences de la matière, Université de Batna-1, Batna 05000, Algeria; Departamento de Biología y Geología, Física y Química Inorgánica, E.S.C.E.T., Universidad Rey Juan Carlos, 28933 Móstoles, Madrid, Sp
[Ti] Title:New cycloartane-type ester triterpenes from Euphorbia pterococca and biological evaluation.
[So] Source:Fitoterapia;, 2018 Mar 07.
[Is] ISSN:1873-6971
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:From acetonic extract of the whole plant Euphorbia pterococca Brot. (Euphorbiaceae), four new cycloartane-type ester triterpenes named cycloartenyl-2'E,4'E-decadienoate (1), cycloartenyl-2'E,4'Z-decadienoate (2), 24-methylenecycloartanyl-2'E,4'Z-tetradecadienoate (3), and 24-oxo-29-norcycloartanyl-2'E,4'Z-hexadecadienoate (4) were obtained along with nine known tetracyclic triterpenes (5-13). Their structures were established mainly by extensive use of spectroscopic techniques, including 1D ( H and C) and 2D homo- and heteronuclear NMR experiments (COSY, HSQC, HMBC and NOESY), and mass spectrometry (HRESIMS), and by comparison with data reported in the literature. In addition, the new compounds 1-3 have been tested for cytotoxicity, trypanocidal effects and on enzymes involved in endocannabinoid degradation. While inactive in all assays up to 100 µM, 1 showed selective inhibition of α/ß-hydrolase 12 with an IC of 11.6 ±â€¯1.9 µM.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  2 / 2054 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29519324
[Au] Autor:Oliveira-Tintino CDM; Pessoa RT; Fernandes MNM; Alcântara IS; da Silva BAF; de Oliveira MRC; Martins AOBPB; da Silva MDS; Tintino SR; Rodrigues FFG; da Costa JGM; de Lima SG; Kerntopf MR; da Silva TG; de Menezes IRA
[Ad] Address:Federal University of Pernambuco (UFPE), Pernambuco, Brazil; Regional University of Cariri (URCA), Ceará, Brazil. Electronic address: datianemorais@hotmail.com.
[Ti] Title:Anti-inflammatory and anti-edematogenic action of the Croton campestris A. St.-Hil (Euphorbiaceae) essential oil and the compound ß-caryophyllene in in vivo models.
[So] Source:Phytomedicine;41:82-95, 2018 Mar 01.
[Is] ISSN:1618-095X
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:BACKGROUND: Inflammation makes up a set of vascularized tissue reactions acting in the defense of the body against harmful stimuli. Natural products are a lower cost alternative with better benefit, often used in popular medicine in the treatment of inflammatory processes. Several species from the genus Croton have scientifically proven anti-inflammatory action. PURPOSE: This study aims to analyze the chemical composition of the Croton campestris A. St.-Hil essential oil (EOCC), derived from fresh leaves, as well as to evaluate the anti-inflammatory potential and the possible mechanisms of action of the EOCC and its constituent ß-caryophyllene. METHODS: The assays were performed in in vivo models of acute and chronic inflammation. Initially, the chemical composition of the EOCC was determined and its oral toxicity was evaluated, followed by the evaluation of its topical antiedematogenic effect through acute and chronic ear edema induced by Croton oil. For the systemic verification of an anti-inflammatory action, the abdominal contortions, formalin test, paw edema induced by carrageenan, dextran, histamine and arachidonic acid models, as well as a peritonitis test, vascular permeability and granuloma assays were performed. RESULTS: The evaluation of the essential oil chemical composition revealed the presence of ß-caryophyllene (15.91%), 1,8-cineol (16.98%) and germacrene-D (14.51%) as its main constituents. The EOCC had no relevant clinical toxicity on oral administration, with an LD of more than 5000 mg/kg. The tested substances showed anti-inflammatory action in the abdominal contortions, paw edema induced by carrageenan, dextran, histamine and arachidonic acid models, the formalin test, peritonitis test and vascular permeability; however, ß-caryophyllene had no significant effect on the granuloma assay. This suggests as a hypothesis that both substances tested showed significant influence on the arachidonic acid and histamine pathway reducing edema in these models. CONCLUSION: The tested substances have a clinically safe profile, additionally the EOCC and ß-caryophyllene presented relevant anti-inflammatory activity. This study supports the hypothesis that ß-caryophyllene, in association with other constituents present in the EOCC such as 1,8-cineole, contributed to the anti-inflammatory effect observed, in addition to suggesting that one of the mechanisms of action probably involves the inhibition of cytokines with the involvement of the arachidonic acid and histamine pathways.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process

  3 / 2054 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29496170
[Au] Autor:Chinnadurai GS; Krishnan S; Perumal P
[Ad] Address:Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai 600025, India.
[Ti] Title:Studies on detection and analysis of proteases in leaf extract of medicinally important plants.
[So] Source:Phytomedicine;40:176-188, 2018 Feb 01.
[Is] ISSN:1618-095X
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:ETHNO-PHARMACOLOGICAL RELEVANCE: The whole plant or the extracts obtained from them have long been used as medicine to treat various human diseases and disorders. Notably, those plants endowed with protease activity have been traditionally used as the agents for treating tumors, digestion disorders, swelling, blood coagulation, fibrinolysis and also for immune-modulation. AIM OF THE STUDY: Proteases occupy a pivotal position in enzyme based industries. Plant proteases have been increasingly exploited for pharmaceutical, food, leather and textile processing industries. Earlier investigations have focused on the occurrence of proteases in medicinally unimportant plants. Therefore it has been aimed to study the occurrence of proteolytic enzymes from medicinally important plants establish any correlation exists between protease activity and medicinal use of individual plants. METHODS: Crude extract were obtained from the leaves of 80 different medicinal plants. Tris-HCl buffer was used as the extraction buffer and the supernatants obtained were used for determination of total protein and protease activity using spectrophotometric methods. Qualitative screening for the presence of protease was carried out with agar diffusion method by incorporating the substrate. SDS-PAGE was used to analyse the isoforms of protease and for determination of relative molecular mass. RESULTS: Relatively higher protease activities were observed in the extracts of leaves of Pongamia pinnata (Fabaceae), Wrightia tinctoria (Apocyanaceae) Acalypha indica (Euphorbiaceae), Adhatoda vasica (Acanthaceae) and Curcuma longa (Zingiberaceae). No correlation was found between the total protein content and protease activity in individual plant species. SDS-PAGE analysis indicated the presence of multiple forms of protease of higher molecular weight range in several plant species. We found a strong correlation between the protease activity and medicinal application of the plant CONCLUSION: The present study has unequivocally revealed that the leaves of medicinal plants could serve as excellent sources of proteases which could be exploited for various industrial, food and pharmaceutical applications.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:In-Process

  4 / 2054 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29421506
[Au] Autor:Krstic G; Jadranin M; Todorovic NM; Pesic M; Stankovic T; Aljancic IS; Tesevic VV
[Ad] Address:Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11158, Belgrade, Serbia.
[Ti] Title:Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis.
[So] Source:Phytochemistry;148:104-112, 2018 Apr.
[Is] ISSN:1873-3700
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Seven previously undescribed jatrophane diterpenoids, nicaeenin A-G, with eight known jatrophane diterpenoids, namely euphodendrophanes A-C, F, N, O, Q, S, were isolated from latex of Euphorbia nicaeensis collected in Serbia. The chemical structures of the compounds were determined by spectroscopic analysis including 1D and 2D NMR and HRESIMS experiments. All but one of the previously undescribed jatrophanes, showed significant potential to inhibit P-glycoprotein (P-gp) activity in two MDR cancer cells (NCI-H460/R and DLD1-TxR). The most powerful were nicaeenin F and nicaeenin G. Moreover nicaeenin G significantly stronger sensitized NCI-H460/R cells to DOX than Dex-VER.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:In-Process

  5 / 2054 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 28587572
[Au] Autor:Maffo T; Melong R; Nganteng DND; Wafo P; Ali MS; Ngadjui BT
[Ad] Address:a Faculty of Science, Department of Organic Chemistry , University of Yaounde I , Yaoundé , Cameroon.
[Ti] Title:Neomacrodione: a new degraded diterpenoid from the roots of Neoboutonia macrocalyx Beng (Euphorbiaceae).
[So] Source:Nat Prod Res;32(1):85-90, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:One new degraded diterpenoid 3,6-dihydroxy-1,7-dimethyl-9,10-phenantroquinone (neomacrodione) (1) together seven known compounds were isolated from the roots of Neoboutonia macrocalyx (Euphorbiaceae). The structures of the compounds were established based on their NMR and mass spectrometric data in conjunction with those previously reported in the literature. Compound (1) displayed moderate antibacterial activities.
[Mh] MeSH terms primary: Anti-Bacterial Agents/chemistry
Diterpenes/chemistry
Euphorbiaceae/chemistry
Phenanthrenes/chemistry
[Mh] MeSH terms secundary: Anti-Bacterial Agents/pharmacology
Diterpenes/pharmacology
Drug Evaluation, Preclinical/methods
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Structure
Phenanthrenes/pharmacology
Plant Roots/chemistry
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Bacterial Agents); 0 (Diterpenes); 0 (Phenanthrenes)
[Em] Entry month:1803
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:IM
[Da] Date of entry for processing:170608
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1335729

  6 / 2054 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29315331
[Au] Autor:Invernizzi C; Nogueira E; Juri P; Santos E; Arredondo D; Branchiccela B; Mendoza Y; Antúnez K
[Ad] Address:Sección Etología, Instituto de Biología, Facultad de Ciencias, Montevideo, Uruguay.
[Ti] Title:Epormenis cestri secretions in Sebastiania schottiana trees cause mass death of honey bee Apis mellifera larvae in Uruguay.
[So] Source:PLoS One;13(1):e0190697, 2018.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:For more than 60 years, sporadic cases of massive summer honey bee larvae mortality in colonies located near freshwater systems with abundant riparian vegetation have been reported in Uruguay. This odd phenomenon, known as "River disease" by beekeepers, can lead to colony death by depopulation. The aim of this study was to detect the causes of larvae death. Different experiments and analyses were performed using affected apiaries located between two important water courses. 1 day old larvae were the most susceptible and substances that killed the larvae were present in the nectar but not in the pollen. A palynological analysis of nectar samples showed that bees collect this resource from commonly pollinated floral species in the country. However, abundant fungi spores and conidia were found, which indicates that the bees also collected honeydews. In the riparian vegetation, bees were observed collecting the secretions of the planthopper Epormenis cestri on Sebastiania schottiana trees. It was found that the mortality period of larvae overlaps with the presence of E. cestri. Larvae maintained in the laboratory were fed (i) nectar from healthy colonies, (ii) nectar from affected colonies, and (iii) secretions of E. cestri. The mortality of the larvae that received nectar from colonies affected with River disease and secretions of E. cestri was higher than the mortality of those receiving nectar from healthy colonies. This represents the first report of planthopper honeydew causing mass larval mortality in honey bees.
[Mh] MeSH terms primary: Colony Collapse
Euphorbiaceae/chemistry
Insecta/metabolism
Larva
[Mh] MeSH terms secundary: Animals
Uruguay
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1802
[Cu] Class update date: 180221
[Lr] Last revision date:180221
[Js] Journal subset:IM
[Da] Date of entry for processing:180110
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190697

  7 / 2054 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29357846
[Au] Autor:Endougou Effa AM; Gantier E; Hennebelle T; Roumy V; Rivière C; Dimo T; Kamtchouing P; Desreumaux P; Dubuquoy L
[Ad] Address:Université Lille Nord de France, F-59000, Lille, France. effanmary@gmail.com.
[Ti] Title:Neoboutonia melleri var velutina Prain: in vitro and in vivo hepatoprotective effects of the aqueous stem bark extract on acute hepatitis models.
[So] Source:BMC Complement Altern Med;18(1):24, 2018 Jan 22.
[Is] ISSN:1472-6882
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Hepatitis is a liver inflammation caused by different agents and remains a public health problem worldwide. Medicinal plants are an important source of new molecules being considered for treatment of this disease. Our work aims at evaluating the hepatoprotective properties of Neoboutonia velutina, a Cameroonian medicinal plant. METHODS: The aqueous extract has been prepared using phytochemical methods. HepG2 cells were used to assess anti-inflammatory properties of the extract at different concentrations. Acute hepatitis models (Carbon tetrachloride and Concanavalin A) were performed in mice receiving or not receiving, different extract doses by gavage. Liver injury was assessed using histology, transaminases and pro-inflammatory markers. Extract antioxidant and radical scavenging capacities were evaluated. RESULTS: The extract led to a significant decrease in pro-inflammatory cytokine expression in vitro and to a remarkable protection of mice from carbon tetrachloride-induced liver injury, as shown by a significant decrease in dose-dependent transaminases level. Upon extract treatment, inflammatory markers were significantly decreased and liver injuries were limited as well. In the Concanavalin A model, the extract displayed weak effects. CONCLUSIONS: Taking into account underlying mechanisms in both hepatitis models, we demonstrate the extract's radical scavenging capacity. Neoboutonia velutina displays a potent hepatoprotective effect mediated through radical scavenging properties.
[Mh] MeSH terms primary: Euphorbiaceae/chemistry
Liver/drug effects
Plant Bark/chemistry
Plant Extracts/pharmacology
Protective Agents/pharmacology
[Mh] MeSH terms secundary: Animals
Carbon Tetrachloride/toxicity
Chemical and Drug Induced Liver Injury/metabolism
Cytokines/analysis
Cytokines/metabolism
Hep G2 Cells
Humans
Male
Mice
Mice, Inbred C57BL
Plant Extracts/chemistry
Protective Agents/chemistry
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Cytokines); 0 (Plant Extracts); 0 (Protective Agents); CL2T97X0V0 (Carbon Tetrachloride)
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[Js] Journal subset:IM
[Da] Date of entry for processing:180124
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-018-2091-2

  8 / 2054 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29438356
[Au] Autor:Guetchueng ST; Nahar L; Ritchie KJ; Ismail FMD; Evans AR; Sarker SD
[Ad] Address:Medicinal Chemistry and Natural Products Research Group, School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, Liverpool L3 3AF, UK. stevnyg@yahoo.fr.
[Ti] Title:Ent-Clerodane Diterpenes from the Bark of Croton oligandrus Pierre ex Hutch. and Assessment of Their Cytotoxicity against Human Cancer Cell Lines.
[So] Source:Molecules;23(2), 2018 Feb 13.
[Is] ISSN:1420-3049
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:New clerodane diterpenes, 12- -megalocarpodolide D ( ) and an epimeric mixture of crotonolins A ( ) and B ( ), were isolated from the bark of following a bioassay-guided isolation protocol. Known compounds, megalocarpodolide D ( ), 12- -crotocorylifuran ( ), cluytyl-ferulate ( ), hexacosanoyl- ferulate ( ), vanillin ( ), acetyl-aleuritolic acid ( ) and lupeol ( ), were also isolated. The structures of the isolated compounds ( - ) were elucidated by spectroscopic means. The cytotoxicity of compounds - was assessed against A549, MCF7, PC3 and PNT2 cell lines using the MTT assay. Compounds and showed moderate levels of activity against both A549 and MCF7 cells with being the most active with IC values of 63.8 ± 13.8 and 136.2 ± 22.7 µM against A549 and MCF7 cells, respectively. The epimeric mixture of and was moderately active against A549 and PC3 cells (IC = 128.6 ± 31.0 and 111.2 ± 2.9 µM, respectively).
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[St] Status:In-Process

  9 / 2054 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29437496
[Au] Autor:Serra DS; Gomes MDM; Cavalcante FSÁ; Leal-Cardoso JH
[Ad] Address:a Institute of Biomedical Sciences , State University of Ceará , Fortaleza , Ceará , Brazil.
[Ti] Title:Essential oil of Croton Zehntneri attenuates lung injury in the OVA-induced asthma model.
[So] Source:J Asthma;:1-10, 2018 Feb 13.
[Is] ISSN:1532-4303
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Croton zehntneri Pax et Hoffm. is a Euphorbiaceae species, popularly known as "canela de cunhã," a native plant of northeastern Brazil, whose essential oil (EOCZ) shows relatively specific myorelaxant action for the smooth muscle of the airways and in the respiratory tract. Based on this information, EOCZ figures as a candidate for testing in the treatment of asthma, and the present study investigated the benefits of using EOCZ in an ovalbumin-induced asthma model. METHODS: 48 male BALB/c mice were divided into six groups (n = 8). In the ST, SO100, and SO300 groups, mice were sensitized and challenged with saline, and then treated with 200 µL of 0.1% Tween 80, 100 mg/kg EOCZ and 300 mg/kg EOCZ, respectively. In the OT, OO100, and OO300 groups, mice were sensitized and challenged with OVA, and then treated with 200 µL of 0.1% Tween 80, 100 mg/kg EOCZ and 300 mg/kg EOCZ, respectively. RESULTS: Our results demonstrated significant changes in all respiratory mechanics variables analyzed between the OO300 and OT groups demonstrating the effectiveness of EOCZ to attenuate the OVA-induced lung injury. In addition, the use of EOCZ at a dose of 300 mg/kg showed an antioxidant effect and decreased inflammatory cells in the pulmonary parenchyma. In conclusion, our results demonstrated that EOCZ was able to improve the lesion in the respiratory system of mice subjected to OVA-induced asthma. CONCLUSIONS: The antioxidant action of EOCZ was likely the main mechanism of action in the reversal of this lesion, so more tests should be performed for its confirmation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[St] Status:Publisher
[do] DOI:10.1080/02770903.2018.1430828

  10 / 2054 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 29345910
[Au] Autor:Gamiotea-Turro D; Camaforte NAP; Valerino-Diaz AB; Ortiz Nuñez Y; Rinaldo D; Dokkedal AL; Bosqueiro JR; Santos LCD
[Ad] Address:UNESP-São Paulo State University, Chemistry Institute-Araraquara. Rua Prof. Francisco Degni , 55 Bairro: Quitandinha, 14800-060 Araraquara, São Paulo, Brazil.
[Ti] Title:Qualitative and Quantitative Analysis of Ethanolic Extract and Phenolic Fraction of Jatropha aethiopica (Euphorbiaceae) Leaves and Their Hypoglycemic Potential.
[So] Source:J Agric Food Chem;66(6):1419-1427, 2018 Feb 14.
[Is] ISSN:1520-5118
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Although Jatropha aethiopica, popularly known in Cuba as "mata diabetes", is used in salads and as a dietary supplement, its chemical composition and antidiabetic properties yet remains unclear. In this work, we evaluate the qualitative and quantitative composition of ethanolic extract (EE) and phenolic fraction (PF) of Jatropha aethiopica leaves and their hypoglycemic and hypolipidemic activity. Chemical fractionation of the ethanolic extract yielded nine compounds, which included protocatechuic acid (1), chlorogenic acid (2), caffeic acid (3), quercetin 3-O-α-l-rhamnopyranosyl-(1 → 2)-[α-l-rhamnopyranolsyl-(1 → 6)]-ß-d-galactopyranoside (4), a new kaempferol 3-O-α-l-rhamnopyranosyl-(1 → 4)-[α-l-rhamnopyranolsyl-(1 → 6)]-ß-d-galactopyranoside (5), kaempferol 3-O-α-l-rhamnopyranosyl-(1 → 2)-[α-l-rhamnopyranolsyl-(1 → 6)]-ß-d-glucopyranoside (6), rutin (7), kaempferol 3-O-α-l-rhamnopyranosyl-(1 → 6)-ß-d-glucopyranoside (8), and quercetin (9). The compounds (1, 4-7) were quantified by high-performance liquid chromatography photodiode array detection (HPLC-PDA) in both the ethanolic extract (62.65 ± 0.15 mg/g) and phenolic fraction (61.72 ± 0.23 mg/g). The results obtained show that both ethanolic extract and phenolic fraction contributed toward the improvement of glucose tolerance, which in turn led to a decline in the glucose levels. Remarkably, the ethanolic extract presented a relatively higher promising effect compared to metformin.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180214
[Lr] Last revision date:180214
[St] Status:In-Process
[do] DOI:10.1021/acs.jafc.7b05648


page 1 of 206 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information