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[PMID]: 29499817
[Au] Autor:Bogdan Y; Helfet DL
[Ad] Address:Department of Orthopaedic Trauma, Geisinger Holy Spirit Orthopaedic Surgery, 550 North 12th Street, Suite 140, Lemoyne, PA 17043, USA. Electronic address: ybogdan@geisinger.edu.
[Ti] Title:Use of Tourniquets in Limb Trauma Surgery.
[So] Source:Orthop Clin North Am;49(2):157-165, 2018 Apr.
[Is] ISSN:1558-1373
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Although tourniquets are commonly used in patients with limb trauma patients, both in the acute and elective settings, no set protocols exist for their indications, contraindications, or proper use. This article addresses the current literature on optimal pressure, timing, cuff design, and complications of tourniquets in trauma patients. General issues are discussed, followed by those specific to upper and lower extremities. Lastly, serious complications, such as pulmonary embolism, are described.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180303
[Lr] Last revision date:180303
[St] Status:In-Process

  2 / 1861 MEDLINE  
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[PMID]: 29325712
[Au] Autor:Li Y; Jia Z; Yi Q; Song X; Liu Y; Jia Y; Wang L; Song L
[Ad] Address:Liaoning Key Laboratory of Marine Animal Immunology and Disease Control, Dalian Ocean University, Dalian 116023, China; Laboratory of Marine Fisheries Science and Food Production Process, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China.
[Ti] Title:A novel GATA-like zinc finger transcription factor involving in hematopoiesis of Eriocheir sinensis.
[So] Source:Fish Shellfish Immunol;74:363-371, 2018 Mar.
[Is] ISSN:1095-9947
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:GATA transcription factor is a family of DNA-binding proteins that can recognize and bind to sequence of (A/T) GATA (A/G). In the present study, a GATA-like protein (named as EsGLP) was characterized from Eriocheir sinensis, including an 834 bp full length open reading frame of EsGLP, encoding a polypeptide of 277 amino acids. The deduced amino acid sequence of EsGLP contained one conserved GATA-type zinc finger of the form Cys-X2-Cys-X17-Cys-X2-Cys, with four cysteine sites. The EsGLP mRNA transcripts were mainly detected in the hematopoietic tissue, hepatopancreas and gonad. The recombinant EsGLP protein was prepared for the antibody production. The EsGLP protein was mainly distributed in the edge of lobules in the HPT and the cytoplasm of hemocytes. The mRNA transcripts of EsGLP in hemocytes were significantly decreased at 24 h (0.39-fold and 0.27-fold, p < .05) and 48 h (0.35-fold and 0.16-fold, p < .05) after LPS and Aeromonas hydrophila stimulation, respectively. However, one peak of EsGLP mRNA transcripts were recorded at 24 h (8.71-fold, p < .05) in HPT after A. hydrophila stimulation. The expression level of EsGLP mRNA in HPT was significantly up-regulated at 2 h, 2.5 h and 9 h (41.74-fold, 45.38-fold and 26.07-fold, p < .05) after exsanguination stimulation. When EsGLP gene expression was inhibited by the injection of double-stranded RNA, both the total hemocytes counts and the rate of EdU-positive hemocytes were significantly decreased (0.32-fold and 0.56-fold compared to that in control group, p < .05). All these results suggested that EsGLP was an important regulatory factor in E. sinensis which involved in the hemocytes generation and the immune response against invading pathogens.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:In-Process

  3 / 1861 MEDLINE  
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[PMID]: 29469960
[Au] Autor:Jouvne C; Fourmaux B; Glon A; Balas L; Durand T; Lagarde M; Ltisse M; Guichardant M
[Ad] Address:Univ-Lyon, CarMeN laboratory, (Inserm UMR 1060, Inra UMR 1397), Universit Claude Bernard Lyon 1, INSA-Lyon, IMBL, 20 Av A. Einstein, F-69100, Villeurbanne, France.
[Ti] Title:Ultra-Performance Liquid Chromatography-Mass Spectrometry Analysis of Free and Esterified Oxygenated Derivatives from Docosahexaenoic Acid in Rat Brain.
[So] Source:Lipids;53(1):103-116, 2018 Jan.
[Is] ISSN:1558-9307
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Docosahexaenoic acid (DHA), a prominent long-chain fatty acid of the omega-3 family, is present at high amount in brain tissues, especially in membrane phospholipids. This polyunsaturated fatty acid is the precursor of various oxygenated lipid mediators involved in diverse physiological and pathophysiological processes. Characterization of DHA-oxygenated metabolites is therefore crucial for better understanding the biological roles of DHA. In this study, we identified and measured, by ultrahigh-performance liquid chromatography coupled with tandem mass spectrometry, a number of oxygenated products derived from DHA in exsanguinated and nonexsanguinated brains. These metabolites were found both in free form and esterified in phospholipids. Interestingly, both (R)- and (S)-monohydroxylated fatty acid stereoisomers were observed free and esterified in phospholipids. Monohydroxylated metabolites were the main derivatives; however, measurable amounts of dihydroxylated products such as protectin DX were detected. Moreover, exsanguination allowed discriminating brain oxygenated metabolites from those generated in blood. These results obtained in healthy rats allowed an overview on the brain oxygenated metabolism of DHA, which deserves further research in pathophysiological conditions, especially in neurodegenerative diseases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:In-Data-Review
[do] DOI:10.1002/lipd.12006

  4 / 1861 MEDLINE  
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[PMID]: 29233761
[Au] Autor:Hidalgo Daz JJ; Muresan L; Touchal S; Bahlouli N; Liverneaux P; Facca S
[Ad] Address:CCOM, FMTS, service de chirurgie de la main, hpitaux universitaires de Strasbourg, 10, avenue Baumann, 67400 Illkirch, France; UMR7357, CNRS, quipe MMB, laboratoire Icube, universit de Strasbourg, 2-4, rue Boussingault, 67000 Strasbourg, France.
[Ti] Title:The new digit tourniquet ForgetMeNot .
[So] Source:Orthop Traumatol Surg Res;104(1):133-136, 2018 Feb.
[Is] ISSN:1877-0568
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:BACKGROUND: Digit tourniquets are widely used in the operating room and even more often in the emergency department to allow the exploration of injuries. A rolled surgical glove finger or silicone catheter placed at the base of the digit is a common method. However, rolled glove tourniquets are easily forgotten under the dressing and may then cause ischemia, which may require amputation. Silicone catheters are expensive single-use devices that may fail to provide effective exsanguination and must be removed by cutting, which may result in skin lesions. The ForgetMeNot digit tourniquet (Arex, Palaiseau, France) was designed to overcome these drawbacks. The objective of this study was to assess the use of ForgetMeNot in our clinical practice. HYPOTHESIS: The ForgetMeNot digit tourniquet is easy to position and remove, effective, and difficult to accidentally leave in place. MATERIAL AND METHODS: ForgetMeNot is composed of two solid cylindrical silicone strands emerging from a central crosspiece bearing two holes through which the ends of the strands can be threaded until stopped by beads on each strand. The device can be sterilised and re-used. It is easy to put in place and to remove. Threading the ends through the holes in the crosspiece forms two loops, which are passed around the tip of the finger. The device is then rolled down to the base of the digit, wrapping around itself and thus tightening gradually. At the end of the surgical procedure, pulling on the flat central crosspiece releases the device. ForgetMeNot was tested by junior and senior surgeons in 86 patients. The following were assessed: pain, tourniquet time, effectiveness of exsanguination, complications, and the learning curve. RESULTS: Positioning the device caused no pain. No patient reported paraesthesia. Remembering to remove the device was made easy by its bright blue or yellow colour. The pressure applied ensured effective exsanguination of the digit. In no case was cutting the device required for removal. Each device was sterilised and re-used several times. DISCUSSION: The new digit tourniquet ForgetMeNot is unlikely to be forgotten, effective, easy to use, re-usable, and associated with a low risk of skin lesions upon removal. LEVEL OF EVIDENCE: III, retrospective uncontrolled study.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180225
[Lr] Last revision date:180225
[St] Status:In-Data-Review

  5 / 1861 MEDLINE  
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[PMID]: 29459299
[Au] Autor:Lu X; Zhang Y; Qin L; Ma W; Zhu L; Luo X
[Ad] Address:Lab of Beef Processing and Quality Control, College of Food Science and Engineering, Shandong Agricultural University, Taian, Shandong 271018, PR China.
[Ti] Title:Association of ultimate pH and stress-related blood variables in cattle.
[So] Source:Meat Sci;139:228-230, 2018 Feb 07.
[Is] ISSN:1873-4138
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The objective of this study was to investigate the relationship between ultimate pH (pHu) and stress-related blood variables. Of 50 cattle in total, blood samples from 6 cattle which exhibited high (≥6.10) pHu (dark-cutting) were collected, along with the same number of low pHu and intermediate pHu cattle (5.40-5.80; 5.80-6.10, respectively) to determine the concentration of plasma cortisol, glucose, lactate, creatine kinase, lactate dehydrogenase, haptoglobin and serum amyloid A protein. Compared to cattle with low pHu, high pHu cattle showed higher plasma cortisol, glucose, lactate, creatine kinase and lactate dehydrogenase levels at exsanguination. But the concentration of haptoglobin and serum amyloid A protein showed no significant differences among three pH groups. These results imply that measuring plasma cortisol, glucose, lactate, creatine kinase, or lactate dehydrogenase levels at exsanguination may be useful to identify the dark-cutting beef condition.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[St] Status:Publisher

  6 / 1861 MEDLINE  
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[PMID]: 29455415
[Au] Autor:O'Donovan S; Langlois NEI; Byard RW
[Ad] Address:Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
[Ti] Title:"Defense" type wounds in suicide.
[So] Source:Forensic Sci Med Pathol;, 2018 Feb 17.
[Is] ISSN:1556-2891
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:"Defense" type wounds are sustained when a victim is attempting to ward off an attacker, or a weapon. A 39-year-old woman is reported who was found deceased with incised wounds to the dorsa of both hands that resembled defense wounds. Examination of the flexor surfaces of both wrists, however, revealed horizontal incised wounds typical of self-infliction. Perfusion of the subclavian arteries produced leakage of water from peripheral veins within wounds on both hands and the right wrist. Death was due to exsanguination from incised wounds of the hands and right wrist; manner suicide. This case demonstrates the difficulties that may arise in differentiating self-inflicted from assaultive wounds. On occasion suicidal sharp force injuries may be multiple and in atypical locations. In these circumstances a high index of suspicion for homicide must be maintained.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180218
[Lr] Last revision date:180218
[St] Status:Publisher
[do] DOI:10.1007/s12024-018-9957-y

  7 / 1861 MEDLINE  
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[PMID]: 29452205
[Au] Autor:Bjerring PN; Bjerrum EJ; Larsen FS
[Ad] Address:Department of Hepatology, Rigshospitalet, Copenhagen, Denmark; The Gastro Unit, Medical Section, Hvidovre Hospital, Hvidovre, Denmark. Electronic address: peter.nissen.bjerring@regionh.dk.
[Ti] Title:Impaired cerebral microcirculation induced by ammonium chloride in rats is due to cortical adenosine release.
[So] Source:J Hepatol;, 2018 Feb 13.
[Is] ISSN:1600-0641
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: Liver failure results in hyperammonaemia, impaired regulation of cerebral microcirculation, encephalopathy and death. However, the key mediator that alters cerebral microcirculation remains unidentified. In this study we show that topical ammonium significantly increases periarteriolar adenosine tone on the brain surface of healthy rats and is associated with a disturbed microcirculation. METHODS: Cranial windows were prepared in anaesthetized Wistar rats. The flow velocities were measured with speckle contrast imaging and compared before and after 30 min of exposure to 10 mM ammonium chloride applied on the brain surface and compared to control groups exposed to artificial cerebrospinal fluid or ammonium + an adenosine receptor antagonist. A flow preservation curve was obtained by analysis of flow responses to a haemorrhagic hypotensive challenge and during stepwise exsanguination. The periarteriolar adenosine concentration was measured with enzymatic biosensors inserted in cortex. RESULTS: After ammonium exposure the arteriolar flow velocity increased by 21.7 (23.4)% vs. controls 7.2 (10.2)% (median (IQR), N=10 and 6, respectively p<0.05) and the arteriolar surface area increased. A profound rise in the periarteriolar adenosine concentration was observed. During the hypotensive challenge the flow decreased by 27.8 (14.9)% vs. 9.2 (14.9)% (p<0.05). The lower limit of flow preservation remained unaffected: 27.7 (3.9) mmHg vs. 27.6 (6.4) mmHg whereas the autoregulatory index increased: 0.29 (0.33) flow units/mmHg vs. 0.03 (0.21) flow units/mmHg (p<0.05). When ammonium exposure was combined with a topical adenosine receptor antagonist the autoregulatory index was normalized. CONCLUSION: Vasodilatation of the cerebral microcirculation during exposure to ammonium chloride is associated with an increase in the adenosine tone. Application of a specific adenosine receptor antagonist restores the regulation of the microcirculation. This indicates that adenosine could be a key mediator in the brain dysfunction seen during hyperammonemia and represents a potential therapeutic target. LAY SUMMARY: In patients with liver failure disturbances in the brain function is caused in part by ammonia toxicity. In our project we have studied how ammonia, through adenosine release, affects the blood flow in the brain of rats. In our experimental model we demonstrated that the detrimental effect of ammonia on blood flow regulation was counteracted by blocking the adenosine receptors in the brain. With this observation we have identified a novel potential treatment target. If we can confirm our findings in a future clinical study it might help patients suffering from liver failure and the severe condition called hepatic encephalopathy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[St] Status:Publisher

  8 / 1861 MEDLINE  
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[PMID]: 29448990
[Au] Autor:Chan T; Bleszynski MS; Youssef DS; Segedi M; Chung S; Scudamore CH; Buczkowski AK
[Ad] Address:Division of General Surgery, Department of General Surgery, University of British Columbia (UBC), Vancouver, BC, Canada.
[Ti] Title:Open abdomen in liver transplantation.
[So] Source:Am J Surg;, 2018 Jan 31.
[Is] ISSN:1879-1883
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Damage control laparotomy with vacuum assisted closure (VAC) is used for selective cases in trauma. In liver transplantation, VAC has also been applied for management of intra-operative hemorrhage. The primary objective was to evaluate peri-operative blood loss and blood product utilization in VAC compared to primary abdominal closure (PAC) at the index transplant operation. METHODS: Retrospective review of all adults undergoing deceased donor liver transplantation (2007-2011) at a single center tertiary care institution. RESULTS: 201 deceased donor liver transplantations were performed, with 167 PAC and 34 VAC cases. Intra-operative blood loss (4.4L vs 10.7L), cell saver return (1399 ml vs 3998 ml), FFP (7.6U vs 15.9U) and PLT requirements (8.5U vs 18.3U), were all significantly elevated in VAC compared to PAC. VAC patients had significantly increased RBC, FFP, PLT, and total volume requirements during initial ICU admission. 30 PAC cases required on demand laparotomy and most commonly for post-operative bleeding. CONCLUSION: In liver transplantation, application of VAC secondary to massive intra-operative exsanguination was safely utilized. Further evaluation is required to identify long-term morbidity and mortality.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[St] Status:Publisher

  9 / 1861 MEDLINE  
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[PMID]: 29425519
[Au] Autor:Robertson A; Hsia TY
[Ad] Address:Department of Perfusion, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. Electronic address: alex.robertson.@gosh.nhs.uk.
[Ti] Title:An Adverse Event Analysis: Inadvertent Exsanguination Following Left Ventricular Assist Device Implantation in a Child.
[So] Source:Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu;21:15-18, 2018 Mar.
[Is] ISSN:1092-9126
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Neurologic deficit subsequent to cardiac surgery remains a cause of postoperative morbidity and mortality. Although myriad risk factors for postoperative cognitive decline have been identified, their individual influence remains undefined. Although less emphasis is now placed on the heart lung machine as the major source of postoperative cognitive decline, the conduct of cardiopulmonary bypass and, in particular, the management of the bypass circuit remain key to patient safety. We present a case of inadvertent intraoperative exsanguination of a patient following open heart surgery for implantation of a left ventricular assist device. The patient suffered significant neurologic damage. However, the nature of the patient's cerebral injury indicated thromboembolism as the likely cause, rather than hypoxic-ischemic injury caused by hypoperfusion. Subsequent investigation of the incident identified several possible sources and potential causes of embolization to the brain that could not rule out the exsanguination event as a contributing factor.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180209
[Lr] Last revision date:180209
[St] Status:In-Process

  10 / 1861 MEDLINE  
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[PMID]: 29197762
[Au] Autor:Stewart SM; McGilchrist P; Gardner GE; Pethick DW
[Ad] Address:Murdoch University, School of Veterinary & Life Sciences, Western Australia 6150, Australia. Electronic address: S.Stewart@murdoch.edu.au.
[Ti] Title:Lamb loin tenderness is not associated with plasma indicators of pre-slaughter stress.
[So] Source:Meat Sci;137:147-152, 2018 Mar.
[Is] ISSN:1873-4138
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The purpose of this study was to test if associations exist between plasma indicators of acute and chronic stress and lamb loin Warner Bratzler Shear Force (WBSF). Blood was collected at exsanguination from 2877 lambs from the Meat and Livestock Genetic Research flock with a suite of indicators analysed. Loin (M. longissimus lumborum) WBSF was measured after 5days aging. Plasma indicators of stress did not relate to WBSF, however a positive association was found between WBSF and kill order, indicating that immediate pre-slaughter factors may be causing reduced tenderness in lamb. In addition, selection for decreased fat depth (PFAT) was associated with increased loin WSBF, indicating that genetic selection for increased carcass leanness is negatively affecting lamb loin tenderness.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180208
[Lr] Last revision date:180208
[St] Status:In-Process


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