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[PMID]: 25596581
[Au] Autor:Valadas E; Badura R; Marques T; Neno M; Boura M; Sutre AF; Beato S; Grácio MA; Neves JC
[Ad] Address:Clínica Universitária de Doenças Infecciosas e Parasitárias, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal. evaladas@medicina.ulisboa.pt.
[Ti] Title:A case of imported neurocysticercosis in Portugal.
[So] Source:J Infect Dev Ctries;9(1):114-7, 2015.
[Is] ISSN:1972-2680
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:Neurocysticercosis (NCC) is the most common cause of acquired epilepsy in resource-poor countries. We report the case of a 24-year-old woman born and residing in Guinea-Bissau, who was transferred to Portugal two months after the onset of a possible meningitis (fever, headache, seizures, and coma) that did not respond to antibiotic treatment. The diagnosis of NCC was confirmed by MR imaging, which showed multiple lesions compatible with cysticercus, and by polymerase chain reaction (PCR) of the cerebrospinal fluid. After 28 days on albendazole and dexamethasone without improvement, she was started on praziquantel, which she completed in six weeks with progressive recovery.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.3855/jidc.5032

  2 / 240712 MEDLINE  
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[PMID]: 25589878
[Au] Autor:Mangione JN; Huy NT; Lan NT; Mbanefo EC; Ha TT; Bao LQ; Nga CT; Tuong VV; Dat TV; Thuy TT; Tuan HM; Huong VT; Hirayama K
[Ad] Address:Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University , 1-12-4 Sakamoto, Nagasaki 852-8523, Japan ; Leiden University Medical Center , C-2-R, P.O. Box 9600, 2300 RC Leiden, the Netherlands....
[Ti] Title:The association of cytokines with severe dengue in children.
[So] Source:Trop Med Health;42(4):137-44, 2014 Dec.
[Is] ISSN:1348-8945
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:BACKGROUND: Dengue virus infection is a major public health problem. A hypothesis put forward for severe dengue is the cytokine storm, a sudden increase in cytokines that induces vascular permeability. Previous studies and our recent meta-analysis showed that IL-6, IL-8, IFNγ, TNFα, VEGF-A and VCAM-1 are associated with dengue shock syndrome. Therefore, in this study we aim to validate the association of these cytokines with severe dengue. METHODS & FINDINGS: In a hospital based-case control study in Vietnam, children with dengue fever, other febrile illness and healthy controls were recruited. Dengue virus infection was confirmed by several diagnostic tests. Multiplex immunoassay using Luminex technology was used to measure cytokines simultaneously. A positive association with dengue shock syndrome was found for VCAM-1, whereas a negative association was found for IFNγ. Furthermore, multivariate logistic analysis also showed that VCAM-1 and IFNγ were independently correlated with dengue shock syndrome. CONCLUSION: IFNγ and VCAM-1 were associated with dengue shock syndrome, although their role in the severe dengue pathogenesis remains unclear. Additional studies are required to shed further light on the function of these cytokines in severe dengue.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150117
[Lr] Last revision date:150117
[Da] Date of entry for processing:150115
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.2149/tmh.2014-09

  3 / 240712 MEDLINE  
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[PMID]: 25590009
[Au] Autor:Zhang J; Xu J; Du X; Yu Y; Lv F
[Ad] Address:1 Department of Infectious Disease, 2 Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China....
[Ti] Title:Rare and persistent Rhodococcus equi infection in a diffuse large B cell lymphoma patient: case report and review of the literature.
[So] Source:J Thorac Dis;6(12):E281-8, 2014 Dec.
[Is] ISSN:2072-1439
[Cp] Country of publication:China
[La] Language:eng
[Ab] Abstract:Rhodococcus equi (R. equi) is an uncommon gram positive organism. It is a rare but recognized pathogen in humans and has emerged as an important cause of morbidity and mortality among immunocompromised patients. Generally, R. equi infection needs combined treatment with effective antibiotics, and often requires the immune adjuvant therapy. Here we reported a 49-year-old man presented dyspnea with fever, skin ulcer for 5 months, and the final diagnosis was diffuse large B cell lymphoma with R. equi septicemia and pneumonia, the treatment was failure, the blood culture was always positive during the course of disease, though he was given combined treatment with effective antibiotics, perhaps the immune reconstitution or immune supportive treatment was more important.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150117
[Lr] Last revision date:150117
[Da] Date of entry for processing:150115
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.3978/j.issn.2072-1439.2014.12.17

  4 / 240712 MEDLINE  
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[PMID]: 25590008
[Au] Autor:Zhou J; Li X; Zeng Q
[Ad] Address:Department of Radiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
[Ti] Title:IgG4-related lung disease with atypical CT imaging: a case report.
[So] Source:J Thorac Dis;6(12):E276-80, 2014 Dec.
[Is] ISSN:2072-1439
[Cp] Country of publication:China
[La] Language:eng
[Ab] Abstract:IgG4-related lung disease is a rare disease, diagnosed when typical pathologic features are seen in the context of increased serum levels of IgG4 and the elevated tissue's IgG4-positive plasma cells. Here we reported the case of a 24-year-old woman with IgG4-related lung disease. This patient presented with fever, cough and shortness of breath. Thoracic computed tomography (CT) images demonstrated multiple nodules or masses with high density in both lungs, and thickened interlobular septa. The 'halo sign' was observed around the high-density lesions of the upper lobes. This range of CT images' characteristics is atypical, which differs from previous reports of this condition.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150117
[Lr] Last revision date:150117
[Da] Date of entry for processing:150115
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.3978/j.issn.2072-1439.2014.12.11

  5 / 240712 MEDLINE  
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[PMID]: 25590000
[Au] Autor:Patris V; Whiteley J; Argiriou O; Lama N; Georgiou H; Constantinou C; Argiriou M; Charitos C
[Ad] Address:1 Department of Cardiac Surgery, Heart and Chest Hospital, Liverpool, UK ; 2 Medical School, University of Ioannina, Ioannina, Greece ; 3 Department of Radiology, Agia Olga General Hospital, Athens, Greece ; 4 Department of Cardiac Surgery, "Evangelismos" General Hospital of Athens, Athens, Greece....
[Ti] Title:Pyrexia in patients with uncontrolled systemic hypertension: could they have an aortic dissection?
[So] Source:J Thorac Dis;6(12):E246-8, 2014 Dec.
[Is] ISSN:2072-1439
[Cp] Country of publication:China
[La] Language:eng
[Ab] Abstract:Aortic dissection can present in a variety of ways and one of the most documented risk factors includes systemic hypertension. Occasionally aortic dissection can be diagnosed late due to an insidious presentation. Fever has been described in people with aortic dissection but rarely as the main presenting feature. We present the cases of two patients with type B aortic dissections who shared three pertinent features which could have alerted the clinicians of the potential diagnosis; systemic hypertension, small left sided pleural effusion and a fever of unknown origin.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150117
[Lr] Last revision date:150117
[Da] Date of entry for processing:150115
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.3978/j.issn.2072-1439.2014.11.13

  6 / 240712 MEDLINE  
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[PMID]: 25589894
[Au] Autor:Sam SS; Teoh BT; Chinna K; AbuBakar S
[Ad] Address:1. Tropical Infectious Diseases Research and Education Center (TIDREC), Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia....
[Ti] Title:High Producing Tumor Necrosis Factor Alpha Gene Alleles in Protection against Severe Manifestations of Dengue.
[So] Source:Int J Med Sci;12(2):177-86, 2015.
[Is] ISSN:1449-1907
[Cp] Country of publication:Australia
[La] Language:eng
[Ab] Abstract:UNLABELLED: Dengue virus (DENV) infection usually presents with mild self-limiting dengue fever (DF). Few however, would present with the more severe form of the disease, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). In the present study, the association between IL-12B, IL-10 and TNF-α gene polymorphisms and dengue severity was investigated. METHODS: A case-control study was performed on a total of 120 unrelated controls, 86 DF patients and 196 DHF/DSS patients. The polymorphisms in IL-12B, IL-10 and TNF-α genes were genotyped using PCR-RFLP and PCR-sequencing methods. RESULTS: A protective association of TNF-α -308A allele and -308GA genotype against DHF/DSS was observed, while TNF-α -238A allele and -238GA genotype were associated with DHF/DSS. A combination of TNF-α -308GA+AA genotype and IL-10 non-GCC haplotypes, IL-12B pro homozygotes (pro1/pro1, pro2/pro2) and IL-12B 3'UTR AC were significantly correlated with protective effects against DHF/DSS. An association between the cytokine gene polymorphisms and protection against the clinical features of severe dengue including thrombocytopenia and increased liver enzymes was observed in this study. CONCLUSION: The overall findings of the study support the correlation of high-producer TNF-α genotypes combined with low-producer IL-10 haplotypes and IL-12B genotypes in reduced risk of DHF/DSS.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150117
[Lr] Last revision date:150117
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.7150/ijms.8988

  7 / 240712 MEDLINE  
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[PMID]: 25487659
[Au] Autor:Bagnall EM; Ho MJ; McCormick IA
[Ad] Address:Department of Medicine, University of British Columbia, Vancouver, BC.
[Ti] Title:A 39-year-old man with recurrent rheumatic fever.
[So] Source:CMAJ;187(1):50-4, 2015 Jan 6.
[Is] ISSN:1488-2329
[Cp] Country of publication:Canada
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150117
[Lr] Last revision date:150117
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.1503/cmaj.140155

  8 / 240712 MEDLINE  
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[PMID]: 25165087
[Au] Autor:Litvintseva AP; Marsden-Haug N; Hurst S; Hill H; Gade L; Driebe EM; Ralston C; Roe C; Barker BM; Goldoft M; Keim P; Wohrle R; Thompson GR; Engelthaler DM; Brandt ME; Chiller T
[Ad] Address:Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia....
[Ti] Title:Valley Fever: Finding New Places for an Old Disease: Coccidioides immitis Found in Washington State Soil Associated With Recent Human Infection.
[So] Source:Clin Infect Dis;60(1):e1-3, 2015 Jan 1.
[Is] ISSN:1537-6591
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We used real-time polymerase chain reaction and culture to demonstrate persistent colonization of soils by Coccidioides immitis, an agent of valley fever, in Washington State linked to recent human infections and located outside the endemic range. Whole-genome sequencing confirmed genetic identity between isolates from soil and one of the case-patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Cu] Class update date: 150117
[Lr] Last revision date:150117
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1093/cid/ciu681

  9 / 240712 MEDLINE  
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[PMID]: 25113611
[Au] Autor:Jackson TL; Paraskevopoulos T; Georgalas I
[Ad] Address:King's College London, London, United Kingdom. Electronic address: t.jackson1@nhs.net.
[Ti] Title:Systematic review of 342 cases of endogenous bacterial endophthalmitis.
[So] Source:Surv Ophthalmol;59(6):627-35, 2014 Nov-Dec.
[Is] ISSN:1879-3304
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We review a total of 342 cases of endogenous bacterial endophthalmitis reported between 1986 and 2012. Predisposing conditions were present in 60%, most commonly diabetes, intravenous drug use, and malignancy. The most common sources of infection were liver, lung, endocardium, urinary tract, and meninges. Systemic features such as fever were present in 74%, hypopyon in 35%, and an absent fundal view in 40%. Diagnostic delay occurred in 26%. Blood cultures were positive in 56%, and at least one intraocular sample was positive in 58% (comprising 26% anterior chamber samples, 59% vitreous taps, and 41% vitrectomy specimens). Worldwide, Gram negative infections (55%) were more frequent than Gram positive (45%) infections, particularly in Asia. Over the last decade, 11% of eyes were treated with systemic antibiotics alone, 10% intravitreal antibiotics alone, 36% systemic plus intravitreal antibiotics, and 20% systemic plus intravitreal antibiotics plus pars plana vitrectomy. The most commonly used intravitreal antibiotics were vancomycin (for Gram positive infection) and ceftazidime (Gram negative). The median final visual acuity was 20/100, with 44% worse than 20/200. Among all cases, 24% required evisceration or enucleation, and mortality was 4%. Both intravitreal dexamethasone and vitrectomy were each associated with a significantly greater chance of retaining 20/200 or better and significantly fewer eviscerations or enucleations-these warrant further study. For most patients, treatment should include a thorough systemic evaluation and prompt intravitreal and systemic antibiotics.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Process

  10 / 240712 MEDLINE  
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[PMID]: 25539816
[Au] Autor:Bassi MR; Kongsgaard M; Steffensen MA; Fenger C; Rasmussen M; Skjødt K; Finsen B; Stryhn A; Buus S; Christensen JP; Thomsen AR
[Ad] Address:Department of International Health, Immunology and Microbiology, University of Copenhagen, DK-2200 Copenhagen N, Denmark;...
[Ti] Title:CD8+ T Cells Complement Antibodies in Protecting against Yellow Fever Virus.
[So] Source:J Immunol;194(3):1141-53, 2015 Feb 1.
[Is] ISSN:1550-6606
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The attenuated yellow fever (YF) vaccine (YF-17D) was developed in the 1930s, yet little is known about the protective mechanisms underlying its efficiency. In this study, we analyzed the relative contribution of cell-mediated and humoral immunity to the vaccine-induced protection in a murine model of YF-17D infection. Using different strains of knockout mice, we found that CD4(+) T cells, B cells, and Abs are required for full clinical protection of vaccinated mice, whereas CD8(+) T cells are dispensable for long-term survival after intracerebral challenge. However, by analyzing the immune response inside the infected CNS, we observed an accelerated T cell influx into the brain after intracerebral challenge of vaccinated mice, and this T cell recruitment correlated with improved virus control in the brain. Using mice deficient in B cells we found that, in the absence of Abs, YF vaccination can still induce some antiviral protection, and in vivo depletion of CD8(+) T cells from these animals revealed a pivotal role for CD8(+) T cells in controlling virus replication in the absence of a humoral response. Finally, we demonstrated that effector CD8(+) T cells also contribute to viral control in the presence of circulating YF-specific Abs. To our knowledge, this is the first time that YF-specific CD8(+) T cells have been demonstrated to possess antiviral activity in vivo.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.4049/jimmunol.1402605


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