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[PMID]: 25645253
[Au] Autor:Jaafar J; Boehlen F; Philippe J; Nendaz M
[Ad] Address:Department of Internal Medicine, Geneva University Hospitals and Faculty of Medicine, Gabrielle-Perret-Gentil 4, Geneva, 1211, Switzerland. jaafar.jaafar@hcuge.ch....
[Ti] Title:Restoration of adrenal function after bilateral adrenal damage due to heparin-induced thrombocytopenia (HIT): a case report.
[So] Source:J Med Case Rep;9(1):18, 2015.
[Is] ISSN:1752-1947
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Patients with bilateral adrenal damage due to heparin-induced thrombocytopenia usually need lifelong steroid substitution. So far, no data exists about the natural evolution of such a condition, especially about adrenal function recovery and the real need for lifelong steroids. CASE PRESENTATION: An 81-year-old Caucasian woman with bilateral adrenal damage due to heparin-induced thrombocytopenia presented with fever and severe hypotension. Adrenal failure was confirmed biologically and radiologically. She eventually recovered her adrenal function, allowing for steroid withdrawal. CONCLUSIONS: This case report addresses the different mechanisms of adrenal damage due to heparin-induced thrombocytopenia and its natural evolution with potential recovery. This should encourage clinicians to evaluate the real necessity for lifelong corticosteroid substitution in such a condition.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1507
[Cu] Class update date: 150718
[Lr] Last revision date:150718
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1186/1752-1947-9-18

  2 / 246867 MEDLINE  
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[PMID]: 26011728
[Au] Autor:Pitisuttithum P; Rerks-Ngarm S; Stablein D; Dawson P; Nitayaphan S; Kaewkungwal J; Michael NL; Kim JH; Robb ML; O'Connell RJ; Yoon IK; Fernandez S; Excler JL
[Ad] Address:Vaccine Trial Center, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand....
[Ti] Title:Accuracy of Clinical Diagnosis of Dengue Episodes in the RV144 HIV Vaccine Efficacy Trial in Thailand.
[So] Source:PLoS One;10(5):e0127998, 2015.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RV144 was a community-based HIV vaccine efficacy trial conducted in HIV-uninfected adults in Thailand, where dengue virus continues to cause a large number of infections every year. We attempted to document the accuracy of clinically diagnosed dengue episodes reported as serious adverse events (SAEs) and adverse events (AEs) and examine whether dengue serology would support the clinical diagnosis. Subjects without a clinical dengue diagnosis but with an infection or idiopathic fever were selected as a control population. Dengue serology was performed by hemagglutination inhibition on plasma samples. A total of 124 clinical dengue episodes were reported (103 SAEs and 21 AEs). Overall 82.6% of the clinically diagnosed dengue episodes were supported by a positive dengue serology: 71.4% of the AEs and 85.0% of the SAEs. Of the 100 subjects with both clinical dengue and positive serology, all presented with fever, 83% with leucopenia, 54% with thrombocytopenia, and 27% with hemorrhagic symptoms. All episodes resolved spontaneously without sequellae. Only two of 15 subjects with a negative serology presented with fever. The sensitivity and specificity of clinical dengue diagnosis were 90.9% and 74.4%, respectively, when compared to the control population, and with a positive predictive value of 82.6% and negative predictive value of 84.7% when compared to dengue serology. Clinical diagnosis of dengue is an accurate method of dengue diagnosis in adults in Thailand. Large-scale clinical trials offer the opportunity to systematically study infectious diseases such as dengue and other infections that may occur during the trial.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Entry month:1505
[Cu] Class update date: 150617
[Lr] Last revision date:150617
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1371/journal.pone.0127998

  3 / 246867 MEDLINE  
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[PMID]: 25927681
[Au] Autor:Rodriguez BF; Mascaraque LR; Fraile LR; Perez IC; Kuder K
[Ad] Address:Medical Doctor (M.D.) Pediatrics/Neonatology, Department of Neonatology, Santa Elena Medical Center , Madrid , Spain.
[Ti] Title:Streptococcus pneumoniae: the forgotten microorganism in neonatal sepsis.
[So] Source:Fetal Pediatr Pathol;34(3):202-5, 2015 Jun.
[Is] ISSN:1551-3823
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:UNLABELLED: Streptococcus pneumoniae is a rarely cause of neonatal sepsis. Its prevalence is low but with a mortality of 50%. Measures to prevent Streptococcus agalactiae transmission could help to increase Invasive Pneumococcal Disease (IPD) in newborns. Transmission could be from mother intrapartum; or in those cases of late onset sepsis, the community carriers. Systematic vaccination with PCV-7 and PCV-13 has reduced IPD rates. We present a case of a newborn with no perinatal risk factors for infection. In the first 24 hours after surgery of an ovarian cyst, the patient started with bad general condition with fever and regular perfusion. Empiric antibiotic treatment was started. Streptococcus pneumoniae was isolated in blood culture. CONCLUSION: In neonatal sepsis, we always think in Streptococcus agalactiae. Streptococcus pneumoniae is rare but with a high morbidity and mortality. Systematic vaccination is a measure that has demonstrated a reduction in the incidence of Invasive pneumococcal disease.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.3109/15513815.2015.1033073

  4 / 246867 MEDLINE  
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[PMID]: 25875109
[Au] Autor:Maciel M; Cruz Fda S; Cordeiro MT; da Motta MA; Cassemiro KM; Maia Rde C; de Figueiredo RC; Galler R; Freire Mda S; August JT; Marques ET; Dhalia R
[Ad] Address:Johns Hopkins University, School of Medicine, Department of Pharmacology & Molecular Sciences, Baltimore, Maryland, United States of America....
[Ti] Title:A DNA vaccine against yellow fever virus: development and evaluation.
[So] Source:PLoS Negl Trop Dis;9(4):e0003693, 2015 Apr.
[Is] ISSN:1935-2735
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Attenuated yellow fever (YF) virus 17D/17DD vaccines are the only available protection from YF infection, which remains a significant source of morbidity and mortality in the tropical areas of the world. The attenuated YF virus vaccine, which is used worldwide, generates both long-lasting neutralizing antibodies and strong T-cell responses. However, on rare occasions, this vaccine has toxic side effects that can be fatal. This study presents the design of two non-viral DNA-based antigen formulations and the characterization of their expression and immunological properties. The two antigen formulations consist of DNA encoding the full-length envelope protein (p/YFE) or the full-length envelope protein fused to the lysosomal-associated membrane protein signal, LAMP-1 (pL/YFE), aimed at diverting antigen processing/presentation through the major histocompatibility complex II precursor compartments. The immune responses triggered by these formulations were evaluated in H2b and H2d backgrounds, corresponding to the C57Bl/6 and BALB/c mice strains, respectively. Both DNA constructs were able to induce very strong T-cell responses of similar magnitude against almost all epitopes that are also generated by the YF 17DD vaccine. The pL/YFE formulation performed best overall. In addition to the T-cell response, it was also able to stimulate high titers of anti-YF neutralizing antibodies comparable to the levels elicited by the 17DD vaccine. More importantly, the pL/YFE vaccine conferred 100% protection against the YF virus in intracerebrally challenged mice. These results indicate that pL/YFE DNA is an excellent vaccine candidate and should be considered for further developmental studies.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1504
[Cu] Class update date: 150718
[Lr] Last revision date:150718
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1371/journal.pntd.0003693

  5 / 246867 MEDLINE  
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SciELO Brazil full text

[PMID]: 25590713
[Au] Autor:Santos JJ; Cordeiro MT; Bertani GR; Marques ET; Gil LH
[Ad] Address:Departamento de Virologia e Terapia Experimental, Centro de Pesquisas Aggeu Magalhães, FIOCRUZ, Recife, PE, Brasil....
[Ti] Title:A two-plasmid strategy for engineering a dengue virus type 3 infectious clone from primary Brazilian isolate.
[So] Source:An Acad Bras Cienc;86(4):1749-59, 2014 Dec.
[Is] ISSN:1678-2690
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:Dengue infections represent one of the most prevalent arthropod-borne diseases worldwide, causing a wide spectrum of clinical outcomes. Engineered infectious clone is an important tool to study Dengue virus (DENV) biology. Functional full-length cDNA clones have been constructed for many positive-strand RNA viruses and have provided valuable tools for studying the molecular mechanisms involved in viral genome replication, virion assembly, virus pathogenesis and vaccine development. We report herein the successful development of an infectious clone from a primary Brazilian isolate of dengue virus 3 (DENV3) of the genotype III. Using a two-plasmid strategy, DENV3 genome was divided in two parts and cloned separately into a yeast-bacteria shuttle vector. All plasmids were assembled in yeast by homologous recombination technique and a full-length template for transcription was obtained by in vitro ligation of the two parts of the genome. Transcript-derived DENV3 is infectious upon transfection into BHK-21 cells and in vitro characterization confirmed its identity. Growth kinetics of transcript-derived DENV3 was indistinguishable from wild type DENV3. This system is a powerful tool that will help shed light on molecular features of DENV biology, as the relationship of specific mutations and DENV pathogenesis.
[Mh] MeSH terms primary: Dengue Virus/genetics
Plasmids/genetics
Transcription, Genetic/genetics
Virus Replication
[Mh] MeSH terms secundary: Brazil
Clone Cells
DNA, Complementary/genetics
Dengue Virus/classification
RNA, Viral/genetics
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (DNA, Complementary); 0 (RNA, Viral)
[Em] Entry month:1506
[Cu] Class update date: 150718
[Lr] Last revision date:150718
[Js] Journal subset:IM
[Da] Date of entry for processing:150116
[St] Status:MEDLINE

  6 / 246867 MEDLINE  
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[PMID]: 26186517
[Au] Autor:Fuchs I; Tarabin S; Kafka M
[Ad] Address:1 Clalit Health Services , Southern district, Beer Sheva, Israel ....
[Ti] Title:Relapsing Fever: Diagnosis Thanks to a Vigilant Hematology Laboratory.
[So] Source:Vector Borne Zoonotic Dis;15(7):446-8, 2015 Jul.
[Is] ISSN:1557-7759
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Three cases of relapsing fever from southern Israel were diagnosed promptly thanks to vigilance of the hematology laboratory technicians. In this region of Israel, patients presenting with prolonged fever and leukopenia without localizing symptoms are generally suspected of having brucellosis or a rickettsial disease. Pediatric patients with prolonged fever, cytopenias, and negative aforementioned serologies are often hospitalized for further work-up. Because of the policy of performing a manual blood smear when results of the automated blood count demonstrate severe anemia and abnormal platelet and/or white blood cell counts, a diagnosis of tick-borne relapsing fever was confirmed and promptly relayed to the physician. This routine prevented unnecessary examinations and hospitalization days and provided important information to regional epidemiology and public health authorities.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1507
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1089/vbz.2014.1764

  7 / 246867 MEDLINE  
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[PMID]: 26186513
[Au] Autor:Yin MY; Qin SY; Tan QD; Feng SY; Liu GX; Zhou DH; Zhu XQ
[Ad] Address:1 State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute , Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province, P.R. China ....
[Ti] Title:First Report of Coxiella burnetii Seroprevalence in Tibetan Sheep in China.
[So] Source:Vector Borne Zoonotic Dis;15(7):419-22, 2015 Jul.
[Is] ISSN:1557-7759
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Query (Q) fever is a vector-borne zoonosis caused by the obligate intracellular pathogen Coxiella burnetii. Animals, including dogs, cats, cattle, and sheep, can be infected by C. burnetii. However, little information is available about C. burnetii infection in Tibetan sheep in China. Antibodies against C. burnetii in Tibetan sheep serums, which were collected from Maqu County, Tianzhu County and Nyingchi Prefecture, China, between 2011 and 2013, were examined by enzyme-linked immunosorbent assay (ELISA). Overall, 14.39% (304/2112, 95% confidence interval [CI] 12.90-15.89) of the examined Tibetan sheep were positive for C. burnetii infection. The C. burnetii seroprevalence in male and female Tibetan sheep was 12.94% (95% CI 10.26-15.61) and 14.98% (95% CI 13.18-16.78), respectively. The seroprevalence varied from 13.19% (95% CI 10.08-16.30) to 14.96% (95% CI 12.31-17.62) in Tibetan sheep in different areas. In addition, the seroprevalence ranged from 13.16% (95% CI 9.83-16.50) to 15.10% (95% CI 13.15-17.04) in different age groups. The results of the present survey indicate that C. burnetii infection is highly prevalent in Tibetan sheep in China. This is the first report of C. burnetii infection in Tibetan sheep in China, extending the host range for C. burnetii. Further studies are warranted to understand better the epidemiological situation of C. burnetii transmission in these areas and elsewhere.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1507
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1089/vbz.2014.1749

  8 / 246867 MEDLINE  
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[PMID]: 26134933
[Au] Autor:Pascucci I; Di Domenico M; Dall'Acqua F; Sozio G; Cammà C
[Ad] Address:Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise "G. Caporale" , Teramo, Italy ....
[Ti] Title:Detection of Lyme Disease and Q Fever Agents in Wild Rodents in Central Italy.
[So] Source:Vector Borne Zoonotic Dis;15(7):404-11, 2015 Jul.
[Is] ISSN:1557-7759
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The maintenance of tick-borne disease agents in the environment strictly depends on the relationship between tick vectors and their hosts, which act as reservoirs for these pathogens. A pilot study aimed to investigate wild rodents as reservoirs for zoonotic tick-borne pathogens (Borrelia burgdorferi sensu lato (s.l.), Coxiella burnetii, Francisella tularensis, and Anaplasma phagocytophilum) was carried out in an area of Gran Sasso e Monti della Laga National Park (Abruzzi Region, central Italy), a wide protected area where, despite sporadic reports of infection in humans and animals, eco-epidemiological data on these diseases are still not available. Rodents were trapped and released at the capture site after the collection of feeding ticks and blood samples. In all, 172 ticks were collected; the most frequent species was Ixodes acuminatus (53%). Out of 88 tick pools, 11 resulted positive for C. burnetii and 13 for B. burgdorferi s.l.; the Borrelia afzelii genospecies was identified in one Ixodes ricinus tick collected from one Apodemus sp. rodent. Out of 143 blood samples, seven Apodemus spp. and five Myodes glareolus were positive for B. burgdorferi s.l. and two Apodemus spp. were positive for C. burnetii. All samples (ticks and blood) were negative for F. tularensis and A. phagocytophilum. This is the first report of B. burgdorferi s.l. in the environment for Abruzzi Region. Data on the presence of B. burgdorferi s.l. are similar to that observed in other Mediterranean countries. The present work is also the first report of C. burnetii in wild rodents in Italy. C. burnetii infection has been largely investigated in Italy in ruminant farms by serology and molecular methods, but information on ecology and on the wild cycle are still lacking. Further studies including genotyping should be performed and species-specific differences between wild rodent reservoirs of Q fever and Lyme disease agents should be investigated.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1507
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1089/vbz.2015.1807

  9 / 246867 MEDLINE  
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[PMID]: 26093678
[Au] Autor:Chen J; Chen W; Zhang L; Li K; Peng S; He M; Hu L
[Ad] Address:The Institute of Ultrasound Engineering in Medicine, Chongqing Medical University, 1 Yixueyuan Road, Box 153, Chongqing 400016, China....
[Ti] Title:Safety of ultrasound-guided ultrasound ablation for uterine fibroids and adenomyosis: A review of 9988 cases.
[So] Source:Ultrason Sonochem;27:671-6, 2015 Nov.
[Is] ISSN:1873-2828
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To evaluate the incidence and severity of adverse reactions to ultrasound-guided ultrasound ablation of uterine fibroids through a multicenter, large-scale retrospective study. METHODS: Between July 2006 and June 2007, 9988 patients with uterine fibroids or adenomyosis were enrolled and received ultrasound ablation treatment under conscious sedation. Forty-two doctors administrated the treatment following a standardized clinical protocol. In-treatment and post-treatment side effects and complications were monitored and each patient was followed up for at least 6months after the treatment. Complications were classified and graded according to the SIR classification system. The technical success and safety of the treatment were evaluated. RESULTS: The mean age of the 9988 patients was 40.4±5.8years (range, 20-56years). Among them, 7438 had uterine fibroids and 2549 had adenomyosis. Specifically, 6545 patients had solitary uterine fibroid, 818 had multiple uterine fibroids, and 76 had fibroids complicated with adenomyosis. There were mainly three types of fibroids: submucous myoma in 89 patients (12.0%), intramural myoma in 5059 patients (68.0%) and subserosal myoma in 1478 patients (20.0%). In terms of fibroid location, 3496 fibroids were found in the anterior wall (47.0%), 2306 in the posterior wall (31.0%), 447 in the lateral wall (6.0%), and 1190 in fundus (16.0%). The length of treatment for uterine fibroids and adenomyosis averaged 84.2±38.8min (range, 30.0-240.0min) and 93.3±55.4min (range, 15.0-240.0min), respectively; and the lengths of sonication were 1243.8±725.2s (range, 506.0-2658.0s) and 1169.7±707.7s (range, 185.0-3600.0s), respectively. Of the uterine fibroids patients, 98.38% (7319/7439) underwent successful ablation with a mean volume ablation rate of 83.1%±15.6% (range, 25-100%). Of the adenomyosis patients, 94.59% (2411/2549) underwent successful ablation with a mean volume ablation rate of 73.2%±23.6% (range, 21-100%). A total of 1062 patients (10.6%) presented with 1305 events of adverse reactions. According to the SIR classification system, 1228 (94.1%) of these reactions fell under Class A; 45 (3.4%) fell under Class B; 24 (1.8%) fell under Class C; and the rest 8 (0.6%) fell under Class D. Adverse reactions included 874 cases (8.67%) of vaginal secretion, 225 cases (2.23%) of lower abdominal pain 24h after the treatment but requiring no painkillers, 76 cases (0.76%) of melosalgia or buttock pain, 52 cases (0.52%) of odynuria, 20 cases (0.20%) of menstruation-like vaginal bleeding, 2 cases (0.2%) of temporary blurred vision, 26 cases (0.26%) of blisters or tangerine pericarp-like burns in the abdominal skin, 16 cases (0.16%) of urinary retention, 4 cases (0.4%) of fever of 38.5°C, 3 cases (0.3%) of acute renal insufficiency, 2 cases (0.2%) of intestinal perforation, and 1 case (0.01%) of long-term lateral ventral syndrome. No permanent injury or fatal complication occurred. CONCLUSIONS: Based on our observations from 9988 cases, ultrasound ablation treatment for uterine fibroid and adenomyosis is highly effective and safe. Adverse reactions to ultrasound ablation under conscious sedation are slight and temporary for both conditions. Hence, this clinically effective and safe treatment is an alternative treatment for women with uterine fibroids and adenomyosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1507
[Js] Journal subset:IM
[St] Status:In-Data-Review

  10 / 246867 MEDLINE  
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[PMID]: 26185916
[Au] Autor:Dotters-Katz SK; Grace MR; Strauss RA; Chescheir N; Kuller JA
[Ad] Address:Clinical Fellow, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC....
[Ti] Title:Chikungunya Fever: Obstetric Considerations on an Emerging Virus.
[So] Source:Obstet Gynecol Surv;70(7):453-7, 2015 Jul.
[Is] ISSN:1533-9866
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Chikungunya fever is an increasingly common viral infection transmitted to humans by species of the Aedes mosquitoes. Characterized by fevers, myalgias, arthralgias, headache, and rash, the infection is endemic to tropical areas. However, identification of disease vectors to Europe and the Americas has raised concern for possible spread of chikungunya to these areas. More recently, these concerns have become a reality; with more than 500,000 new cases in the Western hemisphere in the last 2 years, questions have arisen about the implications of infection during pregnancy and delivery. A literature review was performed using MEDLINE in order to gather information regarding the obstetric implications of this infection. It appears that although this virus can cross the placenta in the first and second trimester leading to fetal infection and miscarriage, this is a very rare occurrence. In contrast, active maternal infection within 4 days of delivery conveys a high risk of vertical transmission. Maternal infection during pregnancy does not appear to be more severe than infection on the nonpregnant female. Given the increasing incidence of chikungunya, obstetric providers should be aware of the disease and its implication for the gravid female.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1507
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1097/OGX.0000000000000184


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