Database : MEDLINE
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[PMID]: 27796940
[Au] Autor:Solanke D; Rathi C; Pandey V; Patil M; Phadke A; Sawant P
[Ad] Address:Department of Gastroenterology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, 400 022, India. dattatraybs@gmail.com.
[Ti] Title:Etiology, clinical profile, and outcome of liver disease in pregnancy with predictors of maternal mortality: A prospective study from Western India.
[So] Source:Indian J Gastroenterol;, 2016 Oct 31.
[Is] ISSN:0975-0711
[Cp] Country of publication:India
[La] Language:ENG
[Ab] Abstract:BACKGROUND: The aim of this study is to study the etiology, clinical profile, and prognostic factors related to maternal and fetal health in pregnant patients with liver disease in Western India. METHODS: This study included 103 consecutive pregnant patients with liver dysfunction from August 2013 to July 2015, who underwent regular biochemical tests, viral markers, ultrasound of abdomen, etc. and were followed up for 6 weeks postpartum or until death. RESULTS: Pregnancy-specific causes of liver dysfunction were found in 39 % (40/103) patients. Liver diseases were most frequent in third trimester 69.9 % (72/103). Etiologies in third trimester were viral hepatitis 36.1 % (26/72), pregnancy induced hypertension (PIH) 30.5 % (22/72), intrahepatic cholestasis of pregnancy 11.1 % (8/72), acute fatty liver of pregnancy (2/72), etc. Hepatitis E was the commonest agent among viral hepatitis 71.8 % (28/39). Causes of maternal mortality (n = 25) were hepatitis E 40 % (10/25), PIH 32 % (8/25), and tropical diseases 20 % (5/25). Fetal mortality (n = 31) was 38.7 % (12/31) in hepatitis E. Maternal mortality was significantly associated with presence of jaundice, fever, abdominal pain, oliguria, anemia, leukocytosis, and coagulopathy. Model for end-stage liver disease (MELD) score >21 predicted maternal mortality with 80 % sensitivity and 91 % specificity (area under the receiver operating characteristic curve = 0.878 and p < 0.001). CONCLUSIONS: Liver disease was most common in the third trimester of pregnancy. Hepatitis E was the most common cause of liver disease in pregnant women in western India with significant maternal mortality, predicted by high MELD score.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:Publisher

  2 / 264825 MEDLINE  
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[PMID]: 27796818
[Au] Autor:Kumar P; Kumar R
[Ad] Address:Department of Pediatrics, Lady Hardinge Medical College & Associated Kalawati Saran Children's Hospital, New Delhi, 110001, India. pkpaed@gmail.com.
[Ti] Title:Enteric Fever.
[So] Source:Indian J Pediatr;, 2016 Oct 29.
[Is] ISSN:0973-7693
[Cp] Country of publication:India
[La] Language:ENG
[Ab] Abstract:Enteric fever is an important public-health problem in India. The clinical presentation of typhoid fever is very variable, ranging from fever with little other morbidities to marked toxemia and associated multisystem complications. Fever is present in majority of patients (>90 %) irrespective of their age group. Mortality is higher in younger children. Blood culture remains gold standard for diagnosis. Widal test has low sensitivity and specificity but may be used in second week to support the diagnosis. Emerging resistance to several antibiotics should be kept in mind when selecting antibiotics or revising the treatment. The key preventive strategies are safe water, safe food, personal hygiene, and appropriate sanitation. Vaccination is an additional effective tool for prevention.
[Pt] Publication type:REVIEW; JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:Publisher

  3 / 264825 MEDLINE  
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[PMID]: 27796503
[Au] Autor:Vlaovic J; Voga G
[Ad] Address:Department of Intensive Internal Medicine, General Hospital Celje, Oblakova ulica 5, 3000, Celje, Slovenia. janko.vlaovic@gmail.com.
[Ti] Title:Spontaneous pulmonary hematoma in a patient with sepsis treated with dual antiplatelet therapy.
[So] Source:Wien Klin Wochenschr;, 2016 Oct 28.
[Is] ISSN:1613-7671
[Cp] Country of publication:Austria
[La] Language:ENG
[Ab] Abstract:A 72-year-old patient was admitted to the medical intensive care unit due to a right-sided, hospital-acquired pneumonia and septic shock with respiratory failure and deterioration of chronic renal failure. During hospitalization the patient required hemodynamic support with norepinephrine and dobutamine, mechanical ventilation and hemodialysis. The patient suffered a non-ST segment elevation myocardial infarction (NSTEMI) and received dual antiplatelet therapy. After 14 days an acute intrapulmonary infiltrate of unknown origin developed, accompanied by fever and a significant increase of the C­reactive protein (CRP) level. Chest radiography and a computed tomography (CT) scan showed a well-defined, round, high-attenuation lesion in the lungs and a suspected infected pulmonary hematoma, which was confirmed by percutaneous aspiration biopsy. There was no evidence of trauma and it is believed that the hematoma occurred spontaneously, probably because of the dual antiplatelet therapy. Double antibiotic treatment was started but no surgery was performed after consultation with a thoracic surgeon. The antiplatelet drugs were temporarily withdrawn until the size of the hematoma showed no further increase and then antiplatelet therapy was continued. After stabilization the patient was discharged from hospital and 6 months later a follow-up chest X­ray showed almost complete resolution of the hematoma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:Publisher

  4 / 264825 MEDLINE  
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[PMID]: 27796430
[Au] Autor:Gürlich K; Herr C; Hendrowarsito L; Weber A; Nennstiel-Ratzel U; Wildner M; Liebl B; Bolte G; Jörres RA; Kolb S; GME-Studiengruppe
[Ad] Address:Sachbereich Arbeits- und Umweltepidemiologie, Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit, Pfarrstraße 3, 80538, München, Deutschland. kathrin.guerlich@gmail.com.
[Ti] Title:Atemwegs- und Allergieerkrankungen bei Kindern : Zeitliche Trends, Stadt-Land-Unterschiede und Assoziationen mit einer Tabakrauchexposition. [Respiratory and allergic diseases of children : Temporal trends, urban-rural differences, and in association with environmental tobacco smoke exposure].
[So] Source:Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz;, 2016 Oct 28.
[Is] ISSN:1437-1588
[Cp] Country of publication:Germany
[La] Language:GER
[Ab] Abstract:BACKGROUND/OBJECTIVES: Ten years after the establishment of health monitoring units (GME) in Bavaria, temporal trends and urban-rural differences in parent-reported respiratory and allergic diseases as well as environmental tobacco smoke (ETS) exposure in preschoolers were analyzed in an explorative manner. Furthermore, associations between diseases and ETS exposure were studied. METHODS: Parent questionnaires were used as part of the school entrance examination in two cross sectional studies (S1:2004/2005, n 1 = 6350; S2:2012/2013, n 2 = 5052). Temporal trends and urban-rural-differences were tested by X(2) tests. Associations between diseases and exposures were studied using multiple logistic regression analysis. RESULTS: The lifetime prevalence of atopic dermatitis declined from S1-S2 from 12.4 to 11.1 %, whereas those for hay fever, asthma, bronchitis and pseudocroup remained stable. In S1 and S2, bronchitis was less often reported in cities. The other diseases showed no urban-rural differences. The prevalence of children's ETS exposure at home declined from S1-S2 from 14.3 to 7.2 % and was generally higher in cities than in rural regions. There was no positive association between diseases and children's ETS exposure at home. In S2 an association was found between asthma and current parental smoking (OR = 1.60; 95 % CI = (1.10-2.32)). CONCLUSION: The GME provide important data for regional distribution of respiratory and allergic diseases and ETS exposure of preschoolers in Bavaria. The results of the study are important for further development of questionnaires, which will be used in future GME.
[Pt] Publication type:JOURNAL ARTICLE; ENGLISH ABSTRACT
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:Publisher

  5 / 264825 MEDLINE  
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[PMID]: 27796214
[Au] Autor:Almuneef M; Alshaalan M; Memish Z; Alalola S
[Ad] Address:a Departments of Pediatrics , King Fahad National Guard Hospital , Riyadh , Saudi Arabia.
[Ti] Title:Bacterial meningitis in Saudi Arabia: The Impact of Haemophilus influenzae Type b Vaccination.
[So] Source:J Chemother;13(sup1):34-39, 2001 Apr.
[Is] ISSN:1973-9478
[Cp] Country of publication:England
[La] Language:ENG
[Ab] Abstract:Bacterial meningitis is one of the major causes of morbidity and mortality in children. A retrospective chart review of all cases of culture-proven bacterial meningitis in children was conducted in a tertiary care facility in the King Fahad National Guard Hospital (KFNGH), Riyadh. Sixty-seven patients with culture- proven meningitis were reviewed. Bacterial meningitis is more common in children under 2 years of age (85%). Haemophilus influenzae type b (Hib) was the most common organism causing meningitis in children (57%). Streptococcus pneumoniae was the second most common organism (31%) followed by group B streptococcus in (7.5%). Fever, lethargy and vomiting were the most common presenting symptoms, occurring in 95%, 72%, and 66% respectively. The calculated incidence of Hib in KFNGH is 40/100,000. This incidence decreased dramatically after the initiation of routine infant vaccination in KFNGH with the conjugate Hib vaccine in April 1998. Outcome of Hib meningitis was good in 85% while outcome of Streptococcus pneumoniae was good in (53%). 43% of S. pneumoniae were resistant to penicillin. There was no cephalosporin-resistant isolate identified during the study period. Mortality due to meningitis was 4 (6%), 3 patients died due to S. pneumoniae and one due to Hib. Since Hib is the most common organism causing meningitis in Saudi Arabian children, mass vaccination of all Saudi children should be mandatory.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:In-Data-Review

  6 / 264825 MEDLINE  
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[PMID]: 27796181
[Au] Autor:Finch RG
[Ad] Address:a Division of Microbiology and Infectious Diseases , Clinical Sciences Bldg, Nottingham City Hospital , Nottingham , NG5 1PB , UK . Fax.
[Ti] Title:Ciprofloxacin: Efficacy and Indications.
[So] Source:J Chemother;12(sup1):5-7, 2000 Jan.
[Is] ISSN:1973-9478
[Cp] Country of publication:England
[La] Language:ENG
[Ab] Abstract:Ciprofloxacin's strength is in 'below-the-diaphragm' indications. Information about the efficacy of the new fluoroquinolones in this indication is currently limited. Ciprofloxacin is effective in both uncomplicated and complicated urinary tract infections, but is probably best reserved for complicated, hospitalacquired or recurrent infections. Ciprofloxacin is effective in complicated and severe lower respiratory tract infections, including those in patients with infective exacerbations of chronic bronchitis and cystic fibrosis, and pseudomonal infections. Ciprofloxacin is effective in the treatment of serious, non-self-limiting intraabdominal infections, peritonitis in CAPD, pelvic inflammatory disease, endometritis and gall-bladder infections. Ciprofloxacin is effective in the treatment of a range of serious, non-selflimiting gastrointestinal infections (e.g. Salmonella and typhoid fever). Ciprofloxacin is effective in the empirical treatment of febrile neutropenic episodes, and prophylaxis of Gram-negative bacteraemia in neutropenia and bone marrow transplantation. Ciprofloxacin is also effective in a range of other indications (e.g. eye infections, skin and soft tissue infections, bone and joint infections, and gonorrhoea).
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:In-Data-Review

  7 / 264825 MEDLINE  
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[PMID]: 27796129
[Au] Autor:Marton I; Simon Z; Borbényi Z
[Ad] Address:II. Belgyógyászati Klinika és Kardiológiai Központ, Haematológiai Osztály, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged, Semmelweis u. 8., 6725.
[Ti] Title:Újdonságok, aktualitások a polycythaemia vera diagnosztikájában és kezelésében. [Diagnosis and treatment of polycythaemia vera: state of the art].
[So] Source:Orv Hetil;157(44):1743-1751, 2016 Oct.
[Is] ISSN:0030-6002
[Cp] Country of publication:Hungary
[La] Language:HUN
[Ab] Abstract:Polycythaemia vera (PV), a condition characterized by blood hyperviscosity due to the expansion of the erythrocyte mass is the most common entity among all Philadelphia chromosome-negative myeloproliferative neoplasms. Arterial and venous thrombotic events are leading determinants of morbidity and mortality but impairment of quality of life due to vasomotor symptoms (erythromelalgia, pruritus) and disease-associated symptoms (tiredness, fatigue, pruritus, night sweats, vision problems, headache, concentration loss, abdominal discomfort, early satiety, fever, weight loss) are also present. The review of polycythaemia vera is actual as the updated WHO 2016 classification of myeloid neoplasms has changed the diagnostic criteria and a new second-line treatment option - JAK1/JAK2 inhibitor ruxolitinib - has been approved for patients who had an inadequate response to or are intolerant of hydroxyurea, which represents a breakthrough in the treatment of this patient population. Orv. Hetil., 2016, 157(44), 1743-1751.
[Pt] Publication type:JOURNAL ARTICLE; ENGLISH ABSTRACT
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:In-Data-Review

  8 / 264825 MEDLINE  
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[PMID]: 27795930
[Au] Autor:Paredes A; Leyton Y; Riquelme C; Morales G
[Ad] Address:Laboratorio Química Biológica, Instituto Antofagasta (IA), Universidad de Antofagasta, Av. Universidad de Antofagasta, 02800 Antofagasta, Chile.
[Ti] Title:A plant from the altiplano of Northern Chile Senecio nutans, inhibits the Vibrio cholerae pathogen.
[So] Source:Springerplus;5(1):1788, 2016.
[Cp] Country of publication:Switzerland
[La] Language:ENG
[Ab] Abstract:BACKGROUND: In the altiplano of Northern Chile the plant Senecio nutans is habitually used as an infusion to relieve the effects of altitude sickness (locally known as "puna"). It is also used to alleviate the bronchitis, whooping cough, asthma, stomachache, tiredness and fever. The extreme conditions under which these plant grow and scientific data that shows the inhibiting potential of the essential oils of plants of the genus Senecio represents great potential in the study of their application to control pathogens like Vibrio Cholera. METHODS: The essential oil from aerial parts of S. nutans was isolated by hydrodistillation and the chemical composition characterized by GC-MS analyses. The antibacterial potential and determination of MIC value, was estimated in both micro and macro dilution method. RESULTS: The GC-MS analysis of essential oil of S. nutans showed the presence of methyl cinnamate (44.9 %), p-cymenol (27.2 %), and terpinen-4-ol (6.8 %), α-terpineol (4.1 %), t-cadinol (3.5 %), methyl hydrocinnamate (2.1 %), δ-cadinene (2.0 %), p-cymene (1.9 %), γ-terpinene (1.8 %), α-cadinol (1.6 %), cis-sabinene hydrate (1.1 %), caryophyllene (0.9 %), ß-pinene (0.8 %), and α-terpinene (0.6 %) as major components. Moreover, the oil of S. nutans exhibited an important antibacterial activity with a diameter of inhibition zone growth of 22 mm and the MIC value of 0.4 mg/mL against pathogenic bacteria V. cholerae. CONCLUSIONS: The results show for the first time the antibacterial activity of the essential oils of S. nutans against the V. cholerae pathogen, an activity that can be applied as a preventive treatment against the action of pathogen.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:In-Data-Review

  9 / 264825 MEDLINE  
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[PMID]: 27795884
[Au] Autor:Atici S; Ünkar ZA; Erdem K; Kadayifci EK; Karaaslan A; Memisoglu AÇ; Soysal A; Toprak NÜ; Söyletir G; Özek E; Bakir M
[Ad] Address:Department of Pediatrics and Division of Pediatric Infectious Diseases Medical School, Marmara University, Istanbul, Turkey ; T.C. Saglik Bakanligi-Marmara Üniversitesi Pendik Egitim ve Arastirma Hastanesi, Fevzi Çakmak Mah. Mimar Sinan Cad. Üstkaynarca, Pendik, Istanbul, Turkey.
[Ti] Title:Ventilator-associated pneumonia caused by Chryseobacterium indologenes: a rare infant case and review of the literature.
[So] Source:Springerplus;5(1):1741, 2016.
[Cp] Country of publication:Switzerland
[La] Language:ENG
[Ab] Abstract:BACKGROUND: Chryseobacterium indologenes is an uncommon organism that has been documented to cause a variety of invasive infections mostly in hospitalized patients with severe underlying diseases. CASE PRESENTATION: A three-month-old female infant born at term by caesarean section with meningomyelocele and congenital diaphragmatic hernia had two surgeries for the repair of meningomyelocele and diaphragmatic hernia on her 3rd and 14th day, respectively. On the 3rd month of her life, she deteriorated clinically with fever, leukocytosis and increase of acute-phase reactants. Gas exchange condition became worse than it was before. Respiratory secretions, oxygen requirements and ventilator demand increased. Chest X-ray showed bilateral pulmonary infiltrates. Bacteriological blood, urine and cerebrospinal fluid culture test results were negative. C. indologenes was isolated from tracheobronchial secretion sample obtained by endotracheal aspiration. Although susceptible to ciprofloxacin (MIC:0.5 gr/L), levofloxacin and piperacillin-tazobactam, the isolate was resistant to meropenem, imipenem and colistin. She was treated with ciprofloxacin successfully. Her fever resolved and gas exchange condition improved after 72 h of the treatment. The antibiotic treatment was given for a course of 14 days. CONCLUSION: Chryseobacterium indologenes may emerge as a potential pathogen in infants with the factors such as invasive equipment, having underlying diseases and prolonged hospitalization.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:In-Data-Review

  10 / 264825 MEDLINE  
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[PMID]: 27795839
[Au] Autor:Mohamed Al Dabal L; Rahimi Shahmirzadi MR; Baderldin S; Abro A; Zaki A; Dessi Z; Al Eassa E; Khan G; Shuri H; Alwan AM
[Ad] Address:Infectious Diseases and Microbiology Units, Rashid Hospital, Dubai Health Authority, Dubai, United Arab Emirates.
[Ti] Title:Crimean-Congo Hemorrhagic Fever in Dubai, United Arab Emirates, 2010: Case Report.
[So] Source:Iran Red Crescent Med J;18(8):e38374, 2016 Aug.
[Is] ISSN:2074-1804
[Cp] Country of publication:United Arab Emirates
[La] Language:ENG
[Ab] Abstract:INTRODUCTION: Crimean-Congo hemorrhagic fever (CCHF) is a severe infectious disease that is not endemic in the United Arab Emirates (UAE). CASE PRESENTATION: We report two cases of confirmed CCHF diagnosed in Dubai, UAE, during Hajj season 2010. Both patients presented with an acute history of high-grade fever, skin rash, and hematemesis. CONCLUSIONS: In spite of maximal supportive measures and intravenous ribavirin therapy, both patients died within a few days from start of illness. More than 250 health care workers came into variable degrees of contact with the index cases, and none of them developed signs or symptoms suggestive of acquiring the illness. Health care workers from nonendemic regions should be aware of zoonotic hemorrhagic fevers imported via infected cattle and ticks and be able to diagnose and properly manage suspected cases in a timely manner. In addition, proper infection-control measures should be undertaken to prevent nosocomial spread of infection.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:In-Data-Review


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