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[PMID]: 25598317
[Au] Autor:Angel-Ambrocio AH; Soto-Acosta R; Tammineni ER; Carrillo ED; Bautista-Carbajal P; Hernández A; Sánchez JA; Del Angel RM
[Ad] Address:Departamento de Infectómica y Patogénesis Molecular, México, D.F., Mexico....
[Ti] Title:An embryonic heart cell line is susceptible to dengue virus infection.
[So] Source:Virus Res;198:53-8, 2015 Feb 16.
[Is] ISSN:1872-7492
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Dengue virus (DENV) is the causative agent of dengue fever. In recent years, patients with more severe form of the disease with acute heart failure or progression to cardiogenic shock and death have been reported. However, the pathogenesis of myocardial lesions and susceptibility of cardiomyocytes to DENV infection have not been evaluated. Under this perspective, the susceptibility of the myoblast cell line H9c2, obtained from embryonic rat heart, to DENV infection was analyzed. Our findings indicate that H9c2 cells are susceptible to the infection with the four DENV serotypes. Moreover, virus translation/replication and viral production in this cell line is as efficient as in other susceptible cell lines, supporting the idea that DENV may target heart cells as evidenced by infection of H9c2 cells. This cell line may thus represent an excellent model for the study and characterization of cardiac physiopathology in DENV infection.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1502
[Js] Journal subset:IM
[St] Status:In-Data-Review

  2 / 241798 MEDLINE  
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[PMID]: 25698823
[Au] Autor:Gavier-Widén D; Ståhl K; Neimanis AS; Segerstad CH; Gortázar C; Rossi S; Kuiken T
[Ad] Address:National Veterinary Institute (SVA), SE-75189 Uppsala, Sweden....
[Ti] Title:African swine fever in wild boar in Europe: a notable challenge.
[So] Source:Vet Rec;176(8):199-200, 2015 Feb 21.
[Is] ISSN:2042-7670
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1502
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1136/vr.h699

  3 / 241798 MEDLINE  
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[PMID]: 25504961
[Au] Autor:Yilmaz S; Cinar M; Simsek I; Erdem H; Pay S
[Ad] Address:Division of Rheumatology, Gulhane School of Medicine, Ankara, Turkey. drsy75@gmail.com....
[Ti] Title:Tocilizumab in the treatment of patients with AA amyloidosis secondary to familial Mediterranean fever.
[So] Source:Rheumatology (Oxford);54(3):564-5, 2015 Mar.
[Is] ISSN:1462-0332
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1502
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.1093/rheumatology/keu474

  4 / 241798 MEDLINE  
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[PMID]: 25697205
[Au] Autor:Lara H B; Aguilera F P; Garrido V M; Hirsch B T; Swadron S; Saldías P F
[Ti] Title:Consultas ambulatorias pediátricas atendidas en el Servicio de Urgencia de un hospital universitario. [Pediatric outpatient consultation at the Emergency Department of a University Hospital].
[So] Source:Rev Chil Pediatr;85(2):174-82, 2014 Apr.
[Is] ISSN:0717-6228
[Cp] Country of publication:Chile
[La] Language:spa
[Ab] Abstract:INTRODUCTION: To determine the epidemiological profile of pediatric consultations treated at the emergency department (ED) is essential for planning processes of medical care and to guide education programs and research. OBJECTIVES: To describe the characteristics of the child population and the main reasons for consultation (RFC) seen in a pediatric emergency service. PATIENTS AND METHOD: A retrospective, descriptive clinical study was conducted regarding the visits to the Children's Emergency Service of an academic hospital in Santiago, for a period of twelve months. RFC were analyzed by age group, severity, seasonality, disposition and frequency of recurrent visits. RESULTS: 24,531 pediatric consultations were evaluated, 51.9% were male (n = 12,720). The age of the patients ranged between one day old and 15 years, with a median age of 36.5 months. 1.5% of patients were newborns (NB), 17.6% were infants (n = 4,326), 51.9% were preschoolers (n = 12,725) and 29% were school children (n = 7,118). Major RFC were fever (n = 6,643, 28.2%), gastrointestinal symptoms (n = 5,606, 23.8%) and respiratory symptoms (n = 5,018, 21.3%), which did not differ significantly according to gender. Most patients (95.5%) were sent to their homes. The risk of hospitalization was more elevated in NB and in those with jaundice (OR = 7.20, 95% CI 3.12 to 16.6), neurological symptoms (OR = 6.90, 95% CI 4.60 -10.4) and poisoning (OR = 6.45, 95% CI 2.82 to 14.7). About 4% were repeat visits, especially in the NB group. CONCLUSIONS: The epidemiological profile of pediatric consultations seen at the ED was similar to that described in previous studies. However, a lower rate of hospitalization was found even though the patients had similar risk profile.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1502
[Js] Journal subset:IM
[St] Status:In-Data-Review

  5 / 241798 MEDLINE  
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[PMID]: 25250972
[Au] Autor:Bansal AK; Vishnubhatla S; Bakhshi S
[Ad] Address:Department of Medical Oncology, All India Institute of Medical Sciences , New Delhi , India.
[Ti] Title:Correlation of serum immunoglobulins with infection-related parameters during induction chemotherapy of pediatric acute myeloid leukemia: a prospective study.
[So] Source:Pediatr Hematol Oncol;32(2):129-37, 2015 Mar.
[Is] ISSN:1521-0669
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Immune dysfunction may be a contributing factor for infections during induction chemotherapy of pediatric acute myeloid leukemia (AML); but this has not been evaluated as yet. PROCEDURE: From April 2010 to May 2011, 45 consecutive de novo pediatric AML patients were prospectively evaluated along with nine healthy controls. Immunoglobulins (Ig) (n = 45) were measured at diagnosis and day 15. RESULTS: There were 25 male and 20 female patients with a median age of 9 years (range 1-18 years). Baseline Ig did not correlate with any of the infection-related parameters during induction. At day 15, Ig levels reduced from baseline (IgG p = 0.46, IgA p = 0.027, IgM p < 0.001). Day 15 IgG levels were lower in patients with persistent fever >7 days (p = 0.029) and fungal infection (p = 0.035). CONCLUSION: This is the first study which has evaluated derangement in Ig with infection-related parameters in pediatric AML. At day 15, immunoglobulins decrease and reduced IgG levels correlate with infection-related parameters. Use of intravenous immunoglobulins in pediatric AML cases needs to be further evaluated to assess whether it can reduce infection-related morbidity.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1502
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.3109/08880018.2014.955620

  6 / 241798 MEDLINE  
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[PMID]: 25293428
[Au] Autor:Heching HJ; Bacha EA; Liberman L
[Ad] Address:Department of Pediatric Cardiology, Morgan Stanley Children's Hospital, 3959 Broadway, 2 North, New York, NY, 10032, USA, hheching@nshs.edu.
[Ti] Title:Post-pericardiotomy syndrome in pediatric patients following surgical closure of secundum atrial septal defects: incidence and risk factors.
[So] Source:Pediatr Cardiol;36(3):498-502, 2015 Mar.
[Is] ISSN:1432-1971
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Surgical repair for atrial septal defects (ASD) generally occurs during childhood. Post-pericardiotomy syndrome (PPS) after cardiac surgery has a reported incidence of 1-40 %. We focused exclusively on secundum ASD repair to evaluate the incidence of PPS. The purpose of this study is to determine the incidence of PPS after surgical repair of secundum ASD and investigate what risk factors may be predictive of its development. A retrospective study was performed, and 97 patients who underwent surgical closure of a secundum ASD were identified. 27 (28 %) were diagnosed with PPS within the first postoperative year. Diagnosis was made if they had evidence of new or worsening pericardial effusion and the presence of ≥2 of the following criteria: fever >72 h postoperatively, irritability, pleuritic chest pain, or pericardial friction rub. Closure of secundum ASDs was performed at a median age of 3.8 years (Interquartile Range (IQR): 2.2-6.0 years) and a median weight of 14.3 kilograms (IQR: 10.9-19.3 kilograms). The median time for development of PPS was 8 days post-op (IQR: 5-14). Significantly, 19 (27 %) of 70 patients in the non-PPS group had a small pericardial effusion on their discharge echocardiogram, while of the 27 patients who developed PPS, 17 (63 %) had a small pericardial effusion on their discharge echocardiogram (p = 0.001). PPS is relatively common following surgical closure of secundum ASDs. A small pericardial effusion on discharge echocardiogram is predictive of development of PPS postoperatively. In patients who develop PPS, there is a good response to therapy with a benign course.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1502
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00246-014-1039-7

  7 / 241798 MEDLINE  
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[PMID]: 25532074
[Au] Autor:Raccichini R; Varzi A; Passerini S; Scrosati B
[Ad] Address:1] Institute of Physical Chemistry, University of Muenster, Corrensstrasse 28/30, D-48149 Muenster, Germany [2] Helmholtz Institute Ulm, Helmholtzstrasse 11, D-89081 Ulm, Germany [3] Karlsruhe Institute of Technology, PO Box 3640, D-76021 Karlsruhe, Germany....
[Ti] Title:The role of graphene for electrochemical energy storage.
[So] Source:Nat Mater;14(3):271-9, 2015 Mar.
[Is] ISSN:1476-1122
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Since its first isolation in 2004, graphene has become one of the hottest topics in the field of materials science, and its highly appealing properties have led to a plethora of scientific papers. Among the many affected areas of materials science, this 'graphene fever' has influenced particularly the world of electrochemical energy-storage devices. Despite widespread enthusiasm, it is not yet clear whether graphene could really lead to progress in the field. Here we discuss the most recent applications of graphene - both as an active material and as an inactive component - from lithium-ion batteries and electrochemical capacitors to emerging technologies such as metal-air and magnesium-ion batteries. By critically analysing state-of-the-art technologies, we aim to address the benefits and issues of graphene-based materials, as well as outline the most promising results and applications so far.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1502
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1038/nmat4170

  8 / 241798 MEDLINE  
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[PMID]: 25699179
[Au] Autor:Cho SJ; Kim SW; Chang JW
[Ad] Address:Department of Anesthesiology and Pain Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Korea.
[Ti] Title:Acute pneumonitis consequent on pleurodesis with Viscum album extract: severe chest images but benign clinical course.
[So] Source:Multidiscip Respir Med;9(1):61, 2014.
[Is] ISSN:1828-695X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Chemical pleurodesis is widely recommended in the treatment of pulmonary air leak of different etiologies as well as malignant pleural effusions and chylothorax. Conventional chemical pleurodesis using erythromycin, tetracycline, hydrophilic fumed silica, autologous blood and talc slurry has been standardized, and its complications, including high fever, intractable chest pain, and acute lung injury, seem to be frequent. Viscum album extract is a new chemical agent for pleurodesis, and only a few studies have reported outcomes of such chemical pleurodesis in the treatment of malignant pleural effusion. Moreover, the complications resulting from pleurodesis using Viscum album extract are very rare, and acute pneumonitis has not been reported. in this paper we report the first case of acute pneumonitis after pleurodesis using Viscum album extract in a 58-year-old man who had prolonged air leaks after a left upper lingularsegmentectomy for metastatic lung cancer. We performed repeated pleurodesis four times with 2 to 4 days intervals. While the patient had no symptoms of pneumonia, such as cough, sputum, chilling, and fatigue, a follow-up chest X-ray revealed increasing peribronchial consolidations and infiltrations in the left upper lobe. A chest tomography showed extensive parenchymal consolidations and ground-glass appearances in the left lungs, representing pneumonia with acute lung injury. The acute pneumonitis was spontaneously resolved with supportive care, and the patient was discharged ten days after the development of pneumonitis. We think that pleurodesis with Viscum album extract is effective, but repeated pleurodesis should be avoided for possible onset of acute pneumonitis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1502
[Da] Date of entry for processing:150220
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1186/2049-6958-9-61

  9 / 241798 MEDLINE  
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[PMID]: 25154820
[Au] Autor:Kochenderfer JN; Dudley ME; Kassim SH; Somerville RP; Carpenter RO; Stetler-Stevenson M; Yang JC; Phan GQ; Hughes MS; Sherry RM; Raffeld M; Feldman S; Lu L; Li YF; Ngo LT; Goy A; Feldman T; Spaner DE; Wang ML; Chen CC; Kranick SM; Nath A; Nathan DA; Morton KE; Toomey MA; Rosenberg SA
[Ad] Address:James N. Kochenderfer, Mark E. Dudley, Sadik H. Kassim, Robert P.T. Somerville, Robert O. Carpenter, Maryalice Stetler-Stevenson, James C. Yang, Q. Phan, Marybeth S. Hughes, Richard M. Sherry, Mark Raffeld, Steven Feldman, Lily Lu, Yong F. Li, Lien T. Ngo, Debbie-Ann N. Nathan, Kathleen E. Morton, M...
[Ti] Title:Chemotherapy-Refractory Diffuse Large B-Cell Lymphoma and Indolent B-Cell Malignancies Can Be Effectively Treated With Autologous T Cells Expressing an Anti-CD19 Chimeric Antigen Receptor.
[So] Source:J Clin Oncol;33(6):540-9, 2015 Feb 20.
[Is] ISSN:1527-7755
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: T cells can be genetically modified to express an anti-CD19 chimeric antigen receptor (CAR). We assessed the safety and efficacy of administering autologous anti-CD19 CAR T cells to patients with advanced CD19(+) B-cell malignancies. PATIENTS AND METHODS: We treated 15 patients with advanced B-cell malignancies. Nine patients had diffuse large B-cell lymphoma (DLBCL), two had indolent lymphomas, and four had chronic lymphocytic leukemia. Patients received a conditioning chemotherapy regimen of cyclophosphamide and fludarabine followed by a single infusion of anti-CD19 CAR T cells. RESULTS: Of 15 patients, eight achieved complete remissions (CRs), four achieved partial remissions, one had stable lymphoma, and two were not evaluable for response. CRs were obtained by four of seven evaluable patients with chemotherapy-refractory DLBCL; three of these four CRs are ongoing, with durations ranging from 9 to 22 months. Acute toxicities including fever, hypotension, delirium, and other neurologic toxicities occurred in some patients after infusion of anti-CD19 CAR T cells; these toxicities resolved within 3 weeks after cell infusion. One patient died suddenly as a result of an unknown cause 16 days after cell infusion. CAR T cells were detected in the blood of patients at peak levels, ranging from nine to 777 CAR-positive T cells/µL. CONCLUSION: This is the first report to our knowledge of successful treatment of DLBCL with anti-CD19 CAR T cells. These results demonstrate the feasibility and effectiveness of treating chemotherapy-refractory B-cell malignancies with anti-CD19 CAR T cells. The numerous remissions obtained provide strong support for further development of this approach.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1502
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1200/JCO.2014.56.2025

  10 / 241798 MEDLINE  
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[PMID]: 25699183
[Au] Autor:Lai KY; Ng WY; Cheng FF
[Ad] Address:Department of Intensive Care, Queen Elizabeth Hospital, HKSAR, B6, 30 Gascoigne Rd, Kowloon, Hong Kong SAR, China.
[Ti] Title:Human Ebola virus infection in West Africa: a review of available therapeutic agents that target different steps of the life cycle of Ebola virus.
[So] Source:Infect Dis Poverty;3:43, 2014.
[Is] ISSN:2049-9957
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The recent outbreak of the human Zaire ebolavirus (EBOV) epidemic is spiraling out of control in West Africa. Human EBOV hemorrhagic fever has a case fatality rate of up to 90%. The EBOV is classified as a biosafety level 4 pathogen and is considered a category A agent of bioterrorism by Centers for Disease Control and Prevention, with no approved therapies and vaccines available for its treatment apart from supportive care. Although several promising therapeutic agents and vaccines against EBOV are undergoing the Phase I human trial, the current epidemic might be outpacing the speed at which drugs and vaccines can be produced. Like all viruses, the EBOV largely relies on host cell factors and physiological processes for its entry, replication, and egress. We have reviewed currently available therapeutic agents that have been shown to be effective in suppressing the proliferation of the EBOV in cell cultures or animal studies. Most of the therapeutic agents in this review are directed against non-mutable targets of the host, which is independent of viral mutation. These medications are approved by the Food and Drug Administration (FDA) for the treatment of other diseases. They are available and stockpileable for immediate use. They may also have a complementary role to those therapeutic agents under development that are directed against the mutable targets of the EBOV.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1502
[Da] Date of entry for processing:150220
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1186/2049-9957-3-43


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