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[PMID]: 25152113
[Au] Autor:Ji Y; Xu L; Huang X
[Ad] Address:Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Lab of HSCT, Beijing 100044, China.
[Ti] Title:[Efficacy and safety of intravenous itraconazole in different antifungal strategies for patients undergoing intensive chemotherapy or hematopoietic stem cell transplantation].
[So] Source:Zhonghua Xue Ye Xue Za Zhi;35(8):689-93, 2014 Aug 14.
[Is] ISSN:0253-2727
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To explore the efficacy and safety of intravenous itraconazole for patients undergoing intensive chemotherapy or hematopoietic stem cell transplantation in different strategies. METHODS: Based on multicenter, observational data, the efficacies of antifungal therapy for patients with persistent fever and suspected IFD in different strategies were calculated retrospectively, and the factors associated with the response of antifungal therapy were explored by logistic analysis. RESULTS: In accordance with the latest published diagnostic criteria and treatment consensus in China, there were 2 patients who were diagnosed as proven IFD ultimately, 20 probable IFD, 19 possible IFD and 133 undefined IFD, respectively. Accordingly, the response rates in targeted therapy for proven/probable IFD patients, diagnostic-driven therapy for possible and undefined IFD patients with clinical or microbiological evidence of IFD, and empirical therapy for undefined patients without any evidence of IFD were 50.0%, 57.4% and 13.5%, respectively (P<0.01). And the multivariable analysis indicated that the presence of radiological or microbiological evidence of IFD before or after the initiation of antifungal therapy was markedly associated with the response to antifungal therapy (P<0.01). The incidence of itraconazolerelated adverse effect was only 2.9%. CONCLUSION: Itraconazole injection was an effective and safe agent in targeted and diagnostic- driven antifungal therapy for immunocompromised or neutropenic febrile patients with hematological malignancies.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.3760/cma.j.issn.0253-2727.2014.08.004

  2 / 236273 MEDLINE  
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[PMID]: 25066737
[Au] Autor:Oreshkova N; Cornelissen LA; de Haan CA; Moormann RJ; Kortekaas J
[Ad] Address:Department of Virology, Central Veterinary Institute of Wageningen University and Research Centre, Lelystad, The Netherlands; Department of Infectious Diseases & Immunology, Virology Division, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. Electronic address: nadia...
[Ti] Title:Evaluation of nonspreading Rift Valley fever virus as a vaccine vector using influenza virus hemagglutinin as a model antigen.
[So] Source:Vaccine;32(41):5323-9, 2014 Sep 15.
[Is] ISSN:1873-2518
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Virus replicon particles are capable of infection, genome replication and gene expression, but are unable to produce progeny virions, rendering their use inherently safe. By virtue of this unique combination of features, replicon particles hold great promise for vaccine applications. We previously developed replicon particles of Rift Valley fever virus (RVFV) and demonstrated their high efficacy as a RVFV vaccine in the natural target species. We have now investigated the feasibility of using this nonspreading RVFV (NSR) as a vaccine vector using influenza virus hemagglutinin as a model antigen. NSR particles were designed to express either the full-length hemagglutinin of influenza A virus H1N1 (NSR-HA) or the respective soluble ectodomain (NSR-sHA). The efficacies of the two NSR vector vaccines, applied via either the intramuscular or the intranasal route, were evaluated. A single vaccination with NSR-HA protected all mice from a lethal challenge dose, while vaccination with NSR-sHA was not protective. Interestingly, whereas intramuscular vaccination elicited superior systemic immune responses, intranasal vaccination provided optimal clinical protection.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review

  3 / 236273 MEDLINE  
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[PMID]: 25012778
[Au] Autor:Purssell E
[Ad] Address:King's College London, James Clerk Maxwell Building, 57 Waterloo Road, London SE1 8WA, United Kingdom. Electronic address: edward.purssell@kcl.ac.uk.
[Ti] Title:Cyclooxygenase inhibitors inhibit antibody response through interference with MAPK/ERK pathways and BLIMP-1 inhibition.
[So] Source:Med Hypotheses;83(3):372-7, 2014 Sep.
[Is] ISSN:1532-2777
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Fever is a common symptom of illness in children, and although not harmful in itself, fever and its associated symptoms are often treated with antipyretic drugs. A number of national and other guidelines now recommend against their routine use; a conclusion that was initially supported by a study showing that the prophylactic use of paracetamol might reduce antibody response to some vaccine antigens, although data from booster vaccinations are more equivocal. Although in vivo data on the cause of this inhibition are scarce, in vitro data suggests that the cause may be due to inhibition of the mitogen activated protein kinase/extracellular regulated protein kinase pathways, and a subsequent reduction in the process of plasma cell differentiation at the beginning of the antibody response. This suggests that in high-risk patients these drugs could be avoided in the early part of an infection when plasma-cell differentiation is occurring. More data are needed to define this period; until then existing data support the recommendation against the routine use of these drugs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review

  4 / 236273 MEDLINE  
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[PMID]: 24961788
[Au] Autor:Kainth MK; Gigliotti F
[Ad] Address:Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY. Electronic address: mkainth@health.nyc.gov.
[Ti] Title:Simultaneous Testing of Erythrocyte Sedimentation Rate and C-Reactive Protein: Increased Expenditure without Demonstrable Benefit.
[So] Source:J Pediatr;165(3):625-7, 2014 Sep.
[Is] ISSN:1097-6833
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We analyzed the practice of paired erythrocyte sedimentation rate and C-reactive protein testing when evaluating fever or inflammation. In our hospital, this resulted in additional charges of $250 000-$400 000/year without demonstrable added benefit to patient care. Extrapolating our results, we estimate reducing this practice could save up to $300 000 000 nationally.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review

  5 / 236273 MEDLINE  
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[PMID]: 24452074
[Au] Autor:Rubartelli A
[Ad] Address:Cell Biology Unit, IRCCS AOU San Martino IST, 16132 Genova, Italy. Electronic address: anna.rubartelli@hsanmartino.it.
[Ti] Title:Autoinflammatory diseases.
[So] Source:Immunol Lett;161(2):226-30, 2014 Oct.
[Is] ISSN:1879-0542
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Autoinflammatory diseases represent an expanding spectrum of genetic and non-genetic inflammatory diseases characterized by recurrent episodes of fever and systemic inflammation affecting the eyes, joints, skin, and serosal surfaces. Thus, these syndromes are recognized as disorders of innate immunity. Confirming this view, most autoinflammatory diseases are uniquely responsive to IL-1 blockade. Although many autoinflammatory diseases have a genetic cause, increasing evidence indicates that the degree of cell stress concurs to the severity of the disease phenotype. In this mini-review, I will discuss the recent advances on pathogenesis, pathophysiology and therapeutic approaches in autoinflammatory syndromes.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review

  6 / 236273 MEDLINE  
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[PMID]: 25150551
[Au] Autor:Tsalis K; Antoniou N; Koukouritaki Z; Patridas D; Sakkas L; Kyziridis D; Lazaridis C
[Ad] Address:4th Department of Surgery, Aristotle University of Thessaloniki, G.Papanikolaou Ho, Thessaloniki, Greece....
[Ti] Title:Successful treatment of recurrent cholangitis by constructing a hepaticojejunostomy with long Roux-en-Y limb in a long-term surviving patient after a Whipple procedure for pancreatic adenocarcinoma.
[So] Source:Am J Case Rep;15:348-51, 2014.
[Is] ISSN:1941-5923
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Background Cholangitis may result from biliary obstruction (e.g., biliary or anastomotic stenosis, or foreign bodies) or occur in the presence of normal biliary drainage. Although reflux of intestinal contents into the biliary tree after hepaticojejunostomy appears to be a rare complication, it is important to emphasize that there are few available surgical therapeutic techniques. Case Report A 74-year-old woman presented to our hospital after 17 years of episodes of cholangitis. The patient had undergone a pancreatoduodenectomy (Whipple procedure) 18 years earlier due to pancreatic adenocarcinoma. The reconstruction was achieved through the sequential placement of pancreatic, biliary, and retrocolic gastric anastomosis into the same jejunal loop. The postoperative course was uneventful and the patient received adjuvant chemotherapy. Approximately 6 months after the initial operation, the patient started having episodes of cholangitis. Over the next 17 years she experienced several febrile episodes presumed to be secondary to cholangitis. A computing tomography (CT) scan of the abdomen revealed intrahepatic bile ducts partially filled with orally administered contrast material (Gastrografin). Magnetic resonance cholangiopancreatography (MRCP) showed dilatation of the left intrahepatic bile ducts. A percutaneous transhepatic cholangiography showed that the bilioenteric anastomosis was normal, without stenosis. Based on these findings, a diagnosis of a short loop between the hepaticojejunostomy and the gastrojejunostomy permitting the reflux of intestinal juice into the biliary tree was made. During the re-operation, a new hepaticojejunal anastomosis in a 100-cm long Roux-en-Y loop was performed to prevent the reflux of the intestinal fluid into the biliary tree. The patient was discharged on postoperative day 10. One year after the second procedure, the patient enjoys good health and has been free of fever and abdominal pain and has not received any antibiotic therapy. Conclusions Lengthening the efferent Roux-en-Y limb should be considered as a therapeutic option when treating a patient with recurrent episodes of cholangitis after hepaticojejunostomy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.12659/AJCR.890436

  7 / 236273 MEDLINE  
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[PMID]: 25151812
[Au] Autor:Otsuka K; Tomii K
[Ti] Title:[How does the physician interpret the patient's narrative as it relates to the physical exam?; New onset symptoms of cough and low grade fever in a patient with chronic cough].
[So] Source:Nihon Naika Gakkai Zasshi;103(6):1429-32, 2014 Jun 10.
[Is] ISSN:0021-5384
[Cp] Country of publication:Japan
[La] Language:jpn
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Process

  8 / 236273 MEDLINE  
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[PMID]: 25151811
[Au] Autor:Kihara M; Wada N
[Ti] Title:[How does the physician interpret the patient's narrative as it relates to the physical exam?; Limb ataxia and a slight fever].
[So] Source:Nihon Naika Gakkai Zasshi;103(6):1423-8, 2014 Jun 10.
[Is] ISSN:0021-5384
[Cp] Country of publication:Japan
[La] Language:jpn
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Process

  9 / 236273 MEDLINE  
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[PMID]: 25148805
[Au] Autor:Chaabane A; Ben Fadhel N; Chadli Z; Ben Fredj N; Boughattas NA; Aouam K
[Ad] Address:Department of Pharmacology, University of Medicine, Monastir, Tunisia. chaabane_amel@yahoo.fr....
[Ti] Title:Phenobarbital-Induced DRESS: A Lichenod Picture.
[So] Source:Iran J Allergy Asthma Immunol;13(6):453-5, 2014 Dec.
[Is] ISSN:1735-1502
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:We describe, the first case of phenobarbital-induced DRESS syndrome presenting as a lichenod eruption. A 49-year-old man had received phenobarbital for a cerebral metastasis. Twenty-five days later, he developed a purplish skin eruption, odynophagia, oral mucosal erosion and fever. Physical examination revealed a cervical lymphadenopathy and facial edema associated to a diffuse violaceous maculo-papular itchy rash. Laboratory findings showed a 1200/mm3 eosinophil's cell count. Alanine aminotransferase was 169 IU/l. Lactate dehydrogenase and creatinine phosphokinase were at 768 and 90 IU/l, respectively. All symptoms resolved completely five weeks after phenobarbital withdrawal. Few days later, the patient died because of a cardio-respiratory arrest.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review

  10 / 236273 MEDLINE  
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[PMID]: 25148518
[Au] Autor:Gallardo C; Fernndez-Pinero J; Pelayo V; Gazaev I; Markowska-Daniel I; Pridotkas G; Nieto R; Fernndez-Pacheco P; Bokhan S; Nevolko O; Drozhzhe Z; Prez C; Soler A; Kolvasov D; Arias M
[Ti] Title:Genetic Variation among African Swine Fever Genotype II Viruses, Eastern and Central Europe.
[So] Source:Emerg Infect Dis;20(9):1544-7, 2014 Sep.
[Is] ISSN:1080-6059
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:African swine fever virus (ASFV) was first reported in eastern Europe/Eurasia in 2007. Continued spread of ASFV has placed central European countries at risk, and in 2014, ASFV was detected in Lithuania and Poland. Sequencing showed the isolates are identical to a 2013 ASFV from Belarus but differ from ASFV isolated in Georgia in 2007.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.3201/eid2009.140554


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