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[PMID]: 27032620
[Au] Autor:Guleryuz K; Doerfler A; Codas R; Coffin G; Hubert J; Lechevallier E; Tillou X; Renal Transplantation Committee of the French Urological Association (CTAFU)
[Ad] Address:Urology Department, CHU de Caen, Caen, France; Normandie University, Normandie, France; UNICAEN, Caen, France....
[Ti] Title:A national study of kidney graft tumor treatments: Toward ablative therapy.
[So] Source:Surgery;160(1):237-44, 2016 Jul.
[Is] ISSN:1532-7361
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Results of the conservative treatment of renal cell carcinomas arising in functional renal transplants are unknown compared to transplant nephrectomy. Only small series or case reports have been reported. METHODS: Data were collected from 32 transplantation centers nationwide on cases of de novo tumors in functional renal transplants presumed to be malignant between January 1988 and December 2013. RESULTS: Among 116 de novo transplant tumors, 62 were treated conservatively including: 48 by partial nephrectomy (PN) and 14 by thermal ablation (TA). These patients were compared to 30 other patients who were treated by transplant nephrectomy. The median age of the transplanted kidneys at the time of diagnosis was 43.5 years old as calculated from the donor's age. Tumors treated by transplant nephrectomy presented more often with symptoms (pain, fever, impaired condition, hematuria) than tumors treated conservatively (P = .019). After PN, final histology showed 27 (47.5%) papillary carcinomas, 19 (32.2%) clear cell carcinomas, 1 mixed carcinoma, and 2 oncocytomas. The median tumor size treated by PN was 24 mm with no difference in comparison to the TA group. Nine patients treated by PN had postoperative complications (21%), including 4 requiring operative intervention (Clavien IIIb). None of the patients treated by TA had complications. Specific survival was 100% at the time of last follow-up (median time after treatment 37 months) for patients treated by PN or TA. CONCLUSION: PN proved to be efficient in the treatment of small tumors of transplanted kidneys with good long-term functional and oncologic outcomes, including avoiding return to dialysis. TA seems to be an alternative therapy with good results in selected patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review

  2 / 258787 MEDLINE  
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[PMID]: 26346417
[Au] Autor:M'Saad S; Kammoun K; Yangui I; Fourati H; Feki W; Marouen F; Daoud E; Kammoun S
[Ad] Address:Service de pneumo-allergologie, CHU Hédi-Chaker, faculté de médecine de Sfax, route al Ain, Km 0,5, 3029 Sfax, Tunisie. Electronic address: msaadsameh@yahoo.fr....
[Ti] Title:Micropolyangéite, syndrome d'emphysème des sommets et fibrose pulmonaire des bases. [Combined pulmonary fibrosis and emphysema associated with microscopic polyangiitis].
[So] Source:Rev Mal Respir;33(5):391-6, 2016 May.
[Is] ISSN:1776-2588
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:BACKGROUND: Combined pulmonary fibrosis and emphysema (CPFE) is a rare entity of unknown etiology. It usually occurs in the context of smoking and, less commonly, connective tissue disease. However, it has been rarely previously described in the context of vasculitis. OBSERVATION: We report a case of CPFE occurring in a 44-year-old man, who was a light smoker without any previous medical history. He presented with fever, chronic cough and breathlessness that progressively evolved to acute respiratory failure. At the initial evaluation, CT scan showed emphysema and patchy bilateral areas of ground-glass opacity. Three years later, the patient simultaneously developed a honeycomb fibrosis and a microscopic polyangiitis with renal involvement justifying the introduction of an immunosuppressive treatment in combination with high dose of systemic corticosteroids. After a stabilization period of 6years, the patient gradually developed chronic respiratory failure with moderate pulmonary hypertension requiring long-term oxygen therapy and nocturnal non-invasive ventilation. CONCLUSION: The association of microscopic polyangiitis to CFPE suggests that autoimmune diseases may have a common pathogenic role in the development of emphysematous and fibrotic lesions in CPFE.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[St] Status:In-Data-Review

  3 / 258787 MEDLINE  
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[PMID]: 27288776
[Au] Autor:Storz C; Schutz C; Tluway A; Matuja W; Schmutzhard E; Winkler AS
[Ad] Address:Department of Neurology, Klinikum Rechts der Isar, Technical University of Munich, Ismaninger Strasse 22, 81675 Munich, Germany. Electronic address: corinna.storz@gmx.de....
[Ti] Title:Clinical findings and management of patients with meningitis with an emphasis on Haemophilus influenzae meningitis in rural Tanzania.
[So] Source:J Neurol Sci;366:52-8, 2016 Jul 15.
[Is] ISSN:1878-5883
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:INTRODUCTION: The spectrum of meningitis pathogens differs depending on the age of patients and the geographic region, amongst other. Although meningitis vaccination programs have led to the reduction of incidence rates, an imbalance between low- and high-income countries still exists. METHODS: In a hospital-based study in rural northern Tanzania, we consecutively recruited patients with confirmed meningitis and described their clinical and laboratory characteristics. RESULTS: A total of 136 patients with meningitis were included. Fever (85%), meningism (63%) and impairment of consciousness (33%) were the most frequent clinical symptoms/signs. Nearly 10% of all patients tested were positive for malaria. The majority of the patients with bacterial meningitis (39%), especially those under 5years of age, were confirmed to be infected with Haemophilus influenzae (26%), Streptococcus pneumoniae (19%) and Neisseria meningitidis (15%). Haemophilus influenzae represented the dominant causative organism in children under 2years of age. CONCLUSION: Our study emphasizes the importance of recognizing warning symptoms like fever, meningism and impairment of consciousness, implementing laboratory tests to determine responsible pathogens and evaluating differential diagnoses in patients with meningitis in sub-Saharan Africa. It also shows that Haemophilus influenza meningitis is still an important cause for meningitis in the young, most probabaly due to lack of appropriate vaccination coverage.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[St] Status:In-Data-Review

  4 / 258787 MEDLINE  
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[PMID]: 25052153
[Au] Autor:Shaw LB; Shaw RA
[Ti] Title:The Pre-Anschluss Vienna School of Medicine--The surgeons: Ignaz Semmelweis (1818-1865), Theodor Billroth (1829-1894) and Robert Bárány (1876-1936).
[So] Source:J Med Biogr;24(1):11-22, 2016 Feb.
[Is] ISSN:1758-1087
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A brief history of the Vienna School of Medicine is sketched out from its founding in the mid-18th century by Gerard van Swieten until the Anschluss in March 1938. The pioneering work of Ignaz Semmelweis on the causes and the prevention of puerperal fever is discussed. This is followed by ground-breaking innovations, particularly in abdominal surgery, by Theodor Billroth and by Robert Bárány's Nobel Prize winning work inter alia on defining the pathology and physiology of the human vestibular apparatus. The lives and work of these three outstanding medical practitioners are described, together with their successes and failures. Only Billroth's achievements were appreciated in Vienna during their lifetimes. Semmelweis' work was belittled during his lifetime and he died obscurely in a mental institution. Bárány had to immigrate to Sweden to achieve recognition.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1602
[Js] Journal subset:IM; QIS
[St] Status:In-Process
[do] DOI:10.1177/0967772014532889

  5 / 258787 MEDLINE  
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[PMID]: 26453091
[Au] Autor:Rob D; Kuchynka P; Palecek T; Cerny V; Masek M; Vitkova I; Rucklova Z; Nemecek E; Zogala D; Linhart A
[Ad] Address:2nd Department of Medicine-Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic....
[Ti] Title:A rare case of regressively changed lipomatous hypertrophy of the interatrial septum presenting with anemia and recurrent fever.
[So] Source:Cardiovasc Pathol;25(2):161-4, 2016 Mar-Apr.
[Is] ISSN:1879-1336
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Lipomatous hypertrophy of the interatrial septum (LHIS) is characterized by excessive accumulation of adipose tissue within some segments of the interatrial septum. Only one published case so far describes fever as a presenting feature of LHIS. On the other hand, systemic symptoms including anemia and fever are well-known clinical presentations of cardiac myxomas. We report an unusual case of a 79-year-old woman who was thoroughly but unsuccessfully investigated for recurrent fever and anemia in several specialized departments over the course of 4 years. Computed tomography scan showed a pathological mass localized in the interatrial septum and spreading to ascending aorta. Histological analysis of the biopsy samples from surgery revealed the unexpected diagnosis of regressively changed LHIS. We discuss the clinical and pathologic features of this lesion suggesting that its regressive changes may be associated with inflammation and can cause systemic symptoms such as fever and anemia.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1602
[Js] Journal subset:IM
[St] Status:In-Process

  6 / 258787 MEDLINE  
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[PMID]: 24363283
[Au] Autor:Schad F; Atxner J; Buchwald D; Happe A; Popp S; Kröz M; Matthes H
[Ad] Address:Hospital Havelhoehe, Berlin, Germany Research Institute Havelhoehe, Berlin, Germany fschad@havelhoehe.de....
[Ti] Title:Intratumoral Mistletoe (Viscum album L) Therapy in Patients With Unresectable Pancreas Carcinoma: A Retrospective Analysis.
[So] Source:Integr Cancer Ther;13(4):332-40, 2014 Jul.
[Is] ISSN:1552-695X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Pancreatic carcinoma remains one of the main causes for cancer-related death. Intratumoral application of anticancer agents is discussed as a promising method for solid tumors such as pancreatic cancer. Endoscopic ultrasound provides a good tool to examine and treat the pancreas. European mistletoe (Viscum album L) is a phytotherapeutic commonly used in integrative oncology in Central Europe. Its complementary use seeks to induce immunostimulation and antitumoral effects as well as alleviate chemotherapeutic side effects. Intratumoral mistletoe application has induced local tumor response in various cancer entities. This off-label use needs to be validated carefully in terms of safety and benefits. Here we report on 39 patients with advanced, inoperable pancreatic cancer, who received in total 223 intratumoral applications of mistletoe, endoscopic ultrasound guided or under transabdominal ultrasound control. No severe procedure-related events were reported. Adverse drug reactions were mainly increased body temperature or fever in 14% and 11% of the applications, respectively. Other adverse drug reactions, such as pain or nausea, occurred in less than 7% of the procedures. No severe adverse drug reaction was recorded. Patients received standard first- and second-line chemotherapy and underwent adequate palliative surgical interventions as well as additive subcutaneous and partly intravenous mistletoe application. A median survival of 11 months was observed for all patients, or 11.8 and 8.3 months for stages III and IV, respectively. Due to the multimodal therapeutic setting and the lack of a control group, the effect of intratumoral mistletoe administration alone remains unclear. This retrospective analysis suggests that intratumoral-applicated mistletoe might contribute to improve survival of patients with pancreatic cancer. In conclusion, the application is feasible and safe, and its efficacy should be evaluated in a randomized controlled trial.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1602
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1177/1534735413513637

  7 / 258787 MEDLINE  
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[PMID]: 26531251
[Au] Autor:Yeap HL; Rasic G; Endersby-Harshman NM; Lee SF; Arguni E; Le Nguyen H; Hoffmann AA
[Ad] Address:Pest and Environmental Adaptation Research Group (PEARG), School of BioSciences, Bio21 Institute, The University of Melbourne, Parkville, Victoria, Australia....
[Ti] Title:Mitochondrial DNA variants help monitor the dynamics of Wolbachia invasion into host populations.
[So] Source:Heredity (Edinb);116(3):265-76, 2016 Mar.
[Is] ISSN:1365-2540
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Wolbachia is the most widespread endosymbiotic bacterium of insects and other arthropods that can rapidly invade host populations. Deliberate releases of Wolbachia into natural populations of the dengue fever mosquito, Aedes aegypti, are used as a novel biocontrol strategy for dengue suppression. Invasion of Wolbachia through the host population relies on factors such as high fidelity of the endosymbiont transmission and limited immigration of uninfected individuals, but these factors can be difficult to measure. One way of acquiring relevant information is to consider mitochondrial DNA (mtDNA) variation alongside Wolbachia in field-caught mosquitoes. Here we used diagnostic mtDNA markers to differentiate infection-associated mtDNA haplotypes from those of the uninfected mosquitoes at release sites. Unique haplotypes associated with Wolbachia were found at locations outside Australia. We also performed mathematical and qualitative analyses including modelling the expected dynamics of the Wolbachia and mtDNA variants during and after a release. Our analyses identified key features in haplotype frequency patterns to infer the presence of imperfect maternal transmission of Wolbachia, presence of immigration and possibly incomplete cytoplasmic incompatibility. We demonstrate that ongoing screening of the mtDNA variants should provide information on maternal leakage and immigration, particularly in releases outside Australia. As we demonstrate in a case study, our models to track the Wolbachia dynamics can be successfully applied to temporal studies in natural populations or Wolbachia release programs, as long as there is co-occurring mtDNA variation that differentiates infected and uninfected populations.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1602
[Cu] Class update date: 160326
[Lr] Last revision date:160326
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1038/hdy.2015.97

  8 / 258787 MEDLINE  
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[PMID]: 26700814
[Au] Autor:Tan J; Pieper K; Piccoli L; Abdi A; Foglierini M; Geiger R; Tully CM; Jarrossay D; Ndungu FM; Wambua J; Bejon P; Fregni CS; Fernandez-Rodriguez B; Barbieri S; Bianchi S; Marsh K; Thathy V; Corti D; Sallusto F; Bull P; Lanzavecchia A
[Ad] Address:Institute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland....
[Ti] Title:A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens.
[So] Source:Nature;529(7584):105-9, 2016 Jan 7.
[Is] ISSN:1476-4687
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Plasmodium falciparum antigens expressed on the surface of infected erythrocytes are important targets of naturally acquired immunity against malaria, but their high number and variability provide the pathogen with a powerful means of escape from host antibodies. Although broadly reactive antibodies against these antigens could be useful as therapeutics and in vaccine design, their identification has proven elusive. Here we report the isolation of human monoclonal antibodies that recognize erythrocytes infected by different P. falciparum isolates and opsonize these cells by binding to members of the RIFIN family. These antibodies acquired broad reactivity through a novel mechanism of insertion of a large DNA fragment between the V and DJ segments. The insert, which is both necessary and sufficient for binding to RIFINs, encodes the entire 98 amino acid collagen-binding domain of LAIR1, an immunoglobulin superfamily inhibitory receptor encoded on chromosome 19. In each of the two donors studied, the antibodies are produced by a single expanded B-cell clone and carry distinct somatic mutations in the LAIR1 domain that abolish binding to collagen and increase binding to infected erythrocytes. These findings illustrate, with a biologically relevant example, a novel mechanism of antibody diversification by interchromosomal DNA transposition and demonstrate the existence of conserved epitopes that may be suitable candidates for the development of a malaria vaccine.
[Mh] MeSH terms primary: Antibodies, Monoclonal/immunology
Antibody Specificity
Antigenic Variation/immunology
Antigens, Protozoan/immunology
Malaria/immunology
Mutagenesis, Insertional/genetics
Plasmodium falciparum/immunology
Receptors, Immunologic/immunology
[Mh] MeSH terms secundary: Amino Acid Sequence
Antibodies, Monoclonal/chemistry
Antibodies, Monoclonal/genetics
Antibodies, Monoclonal/therapeutic use
B-Lymphocytes/cytology
B-Lymphocytes/immunology
Clone Cells/cytology
Clone Cells/immunology
Collagen/immunology
Collagen/metabolism
Conserved Sequence/immunology
DNA Transposable Elements/genetics
DNA Transposable Elements/immunology
Epitopes, B-Lymphocyte/chemistry
Epitopes, B-Lymphocyte/immunology
Erythrocytes/immunology
Erythrocytes/metabolism
Erythrocytes/parasitology
Humans
Kenya
Malaria/parasitology
Malaria Vaccines/chemistry
Malaria Vaccines/immunology
Membrane Proteins/chemistry
Membrane Proteins/immunology
Molecular Sequence Data
Protein Structure, Tertiary/genetics
Protozoan Proteins/chemistry
Protozoan Proteins/immunology
Receptors, Immunologic/chemistry
Receptors, Immunologic/genetics
Receptors, Immunologic/metabolism
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Antibodies, Monoclonal); 0 (Antigens, Protozoan); 0 (DNA Transposable Elements); 0 (Epitopes, B-Lymphocyte); 0 (Malaria Vaccines); 0 (Membrane Proteins); 0 (Protozoan Proteins); 0 (RIFIN protein, Plasmodium falciparum); 0 (Receptors, Immunologic); 0 (leukocyte-associated immunoglobulin-like receptor 1); 9007-34-5 (Collagen)
[Em] Entry month:1601
[Cu] Class update date: 160612
[Lr] Last revision date:160612
[Js] Journal subset:IM
[Da] Date of entry for processing:160107
[St] Status:MEDLINE
[do] DOI:10.1038/nature16450

  9 / 258787 MEDLINE  
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[PMID]: 26982342
[Au] Autor:Samudra N; Figueroa S
[Ad] Address:Department of Neurology, University of Texas Southwestern Medical Center , Dallas, Texas.
[Ti] Title:Intractable Central Hyperthermia in the Setting of Brainstem Hemorrhage.
[So] Source:Ther Hypothermia Temp Manag;6(2):98-101, 2016 Jun.
[Is] ISSN:2153-7933
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Hyperthermia from a central cause is associated with increased morbidity and mortality. Dysfunction of brainstem thermoregulatory pathways may explain the intractable rise in temperature. Antipyretics, dantrolene, bromocriptine, and surface and intravascular cooling devices have been attempted for temperature control. We report the case of a 54-year-old woman with history of hypertension who presented with pontine hemorrhage with extension into the midbrain and medulla. On days 8-9 of her hospital admission, she developed intractable fever and expired the same day despite aggressive treatment of hypothermia, including antipyretics, ice lavage, cold fluid boluses, surface cooling, dantrolene, and bromocriptine. Hyperthermia from brainstem hemorrhage can be difficult to manage with current treatment options. Early recognition of those patients who may develop hyperthermia could lead to early intervention and possibly better outcomes. More evidence from prospective randomized controlled trials will elucidate the risk-benefit profile of achieving normothermia with aggressive fever control in these patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1089/ther.2016.0004

  10 / 258787 MEDLINE  
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[PMID]: 27285991
[Au] Autor:Jain R; Trehan A; Mishra B; Singh R; Saud B; Bansal D
[Ad] Address:a Division of Pediatric Hematology and Oncology, Department of Pediatrics , Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research , Chandigarh , India....
[Ti] Title:Cytomegalovirus disease in children with acute lymphoblastic leukemia.
[So] Source:Pediatr Hematol Oncol;33(4):239-47, 2016 May.
[Is] ISSN:1521-0669
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Viral infections are an underrecognized problem in children on standard chemotherapy for acute lymphoblastic leukemia (ALL). In countries with high baseline seroprevalence of cytomegalovirus (CMV) such as India, it may be an important pathogen leading to fever, end-organ damage, and cytopenia. Data regarding the incidence and manifestations of CMV disease in pediatric ALL patients are scanty. The authors prospectively assessed all children on chemotherapy for ALL with prolonged febrile neutropenia (FN) for CMV disease over a 3-year period. Children with end-organ damage, including pneumonia, retinitis, and colitis, were also evaluated. Quantitative and qualitative polymerase chain reaction (PCR) from blood, body fluids, or tissue was done along with ophthalmologic evaluation. CMV disease was detected in 10% of the children with prolonged FN. In addition, other children were identified due to end-organ damage, lung and eye being the common organs of involvement. Time of CMV reactivation was essentially during nonintense phase of chemotherapy. Lymphopenia was present in most children, and prolonged lymphopenia was associated with relapse of CMV infection after therapy. The authors conclude that CMV is an important pathogen in children on standard chemotherapy for ALL. It has a good outcome with early detection and directed therapy. Parenteral ganciclovir is needed for a period of 14-21 days to prevent recurrence.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.3109/08880018.2016.1173147


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