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[PMID]: 29520188
[Au] Autor:Lee GY; Lee JW; Yeom JS; Kim KJ; Shin HI; Kang HS
[Ad] Address:Department of Radiology, Seoul National University Bundang Hospital, Seongnam 13620, Korea.
[Ti] Title:The Incidence of Various Types of Systemic Reactions Related to Epidural Steroid Injections: A Prospective Observational Study.
[So] Source:Korean J Radiol;19(2):301-310, 2018 Mar-Apr.
[Is] ISSN:2005-8330
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:Objective: To evaluate the incidence, types and association of systemic reactions after an epidural steroid injection (ESI) with patient demographics, ESI factors and repeated occurrence of an ESI. Materials and Methods: This prospective observational study was approved by the Institutional Review Board of our hospital, and written informed consent was obtained from all the participants. From October to December 2011, systemic reactions at 2 weeks after 960 ESIs among 885 patients were measured. Patients were evaluated by phone interviews to obtain the patients' demographics, history of previous ESI, ESI factors, and ESI reoccurrence. Statistical analyses were performed using the chi-square tests, Fisher's exact tests and a binary logistic regression analysis. Results: Overall, 557 types of systemic reactions occurred after 292 injections (30.4%) of a total of 960 ESIs in which facial flushing was most common (131/557, 23.5%) and 144 ESIs were followed by a mixed form of systemic reactions (49.3%). Age of 62 years or younger (odds ratio [OR], 2.361), female sex (OR, 1.674), and history of diabetes mellitus (OR, 1.681) were significant risk factors in the occurrence of systemic reactions after an ESI. In 73 patients with repeated ESI, 14 patients re-experienced systemic reactions (19.2%), of which twelve re-experienced the same systemic reaction as the previous one. Conclusion: Systemic reactions followed about 30% of ESIs, and more commonly occurred in patients 62 years of age or younger, women, and diabetic patients. Half of the patients experienced a mixed form of systemic reactions. Patients with recurring systemic reactions tend to re-experience the same systemic reaction as the prior one after an ESI.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Data-Review
[do] DOI:10.3348/kjr.2018.19.2.301

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[PMID]: 29524232
[Au] Autor:Ko H; Song YM; Lee SC; Park SW; Sung J; Lee K; Lee E
[Ad] Address:Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
[Ti] Title:Association between excessive alcohol consumption and echocardiographic parameters according to the presence of flushing reaction in Korean men: A community based study.
[So] Source:Alcohol Clin Exp Res;, 2018 Mar 10.
[Is] ISSN:1530-0277
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: The objective of this study was to investigate the effect of excessive alcohol consumption on heart reflected by various echocardiographic parameters according to the presence or absence of flushing reaction that might reflect acetaldehyde metabolism. METHODS: A total of 854 Korean men without significant cardiovascular diseases who underwent echocardiography and participated in the Korean Healthy Twin Study were used as subjects of this study. These subjects were classified into three categories: non-drinker, moderate drinker (≤ 196 g/week), and heavy drinker (> 196 g/week) within two strata of flushing reaction to alcohol drinking. Association between echocardiographic measurements and categories of the amount of alcohol consumption considering flushing reaction were evaluated using mixed linear regression model. RESULTS: The proportion of flushers among drinkers was 39.5% (278 of 703). In stratified analysis by flushing reaction, non-flushers showed significantly higher left ventricular mass index (ß: 4.605; 95% CI: 0.966, 8.243) and significantly lower ratio of peak early diastolic velocities (E peak) over peak late diastolic velocities of mitral inflow (ß: -0.103; 95% CI: -0.198, -0.008) in heavy drinkers compared to non-drinkers. Flushers showed significantly higher left atrial volume index (ß: 2.712; 95% CI: 0.456, 4.968) in heavy drinkers and significantly lower ratio of E peak over the peak early diastolic mitral annular velocities (ß: -0.493; 95% CI: -0.902, -0.085) in moderate drinkers compared to non-drinkers. However, the interaction according to flushing reaction was only statistically significant for the association between alcohol consumption and left atrial volume index (p for interaction = 0.004). CONCLUSION: Alcohol consumption is associated with changes in cardiac structure and function. Such association might be influenced by acetaldehyde metabolism. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1111/acer.13622

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[PMID]: 29460428
[Au] Autor:Gelernter J; Zhou H; Nuñez YZ; Mutirangura A; Malison RT; Kalayasiri R
[Ad] Address:Yale University School of Medicine, Department of Psychiatry, New Haven, CT.
[Ti] Title:Genomewide association study of alcohol dependence and related traits in a Thai population.
[So] Source:Alcohol Clin Exp Res;, 2018 Feb 20.
[Is] ISSN:1530-0277
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Alcohol use (both quantity and dependence) is moderately heritable, and genomewide association studies (GWAS) have identified risk genes in European, African, and Asian populations. The most reproducibly identified risk genes affect alcohol metabolism. Well-known functional variants at the gene encoding alcohol dehydrogenase B (ADH1B) and other alcohol dehydrogenases affect risk in European and African-ancestry populations. Similarly, variants mapped to these same genes and a well-known null variant that maps to the gene that encodes aldehyde dehydrogenase 2 (ALDH2) also affect risk in various Asian populations. In this study we completed the first GWAS for three traits related to alcohol use in a Thai population recruited initially for studies of methamphetamine dependence. METHODS: All subjects were evaluated with the Thai version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA). A total of 1045 subjects were available for analysis. Three traits were analyzed: flushing, maximum number of alcoholic beverages consumed in any lifetime 24-hour period ("MAXDRINKS"), and DSM-IV alcohol dependence criterion count. We also conducted a pleiotropy analysis with major depression, the only other psychiatric trait where summary statistics from a large-scale Asian-population GWAS are available. RESULTS: All three traits showed genomewide-significant association with variants near ALDH2, with significance ranging from 2.01×10 (for flushing; lead SNP PTPN11* rs143894582) to p = 5.80 × 10 (for alcohol dependence criterion count; lead SNP rs149212747). These lead SNPs flank rs671 and span a region of over a megabase, illustrating the need for prior biological information in identifying the actual effect SNP, rs671. We also identified significant pleiotropy between major depression and flushing. CONCLUSIONS: These results are consistent with prior findings in Asian populations and add new information regarding alcohol use-depression pleiotropy. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1111/acer.13614

  4 / 8474 MEDLINE  
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[PMID]: 29446654
[Au] Autor:Yamanaka H; Taniguchi A; Tsuboi H; Kano H; Asami Y
[Ad] Address:a Institute of Rheumatology , Tokyo Women's Medical University , Tokyo , Japan.
[Ti] Title:Hypouricaemic effects of yoghurt containing Lactobacillus gasseri PA-3 in patients with hyperuricaemia and/or gout: A randomised, double-blind, placebo-controlled study.
[So] Source:Mod Rheumatol;:1-5, 2018 Mar 09.
[Is] ISSN:1439-7609
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: Lactobacillus gasseri PA-3 (PA-3) has been previously shown to decrease serum uric acid (SUA) levels in subjects with increased SUA. In this study, we investigated whether PA-3 is also capable of decreasing SUA levels in patients with hyperuricaemia and/or gout. METHODS: Twenty-five patients with hyperuricaemia and/or gout completed this study. Urate-lowering drugs were discontinued for 12 weeks (week -4 to week 8). After flushing of urate-lowering drugs for 4 weeks (week 0), patients were randomised equally to receive diets containing yoghurt beverages with PA-3 or without PA-3 for a duration of 8 weeks (week 8). The intention to treat (ITT) population included all subjects who were randomised, and the per-protocol (PP) population included subjects who completed the experiment with compliance. We evaluated SUA levels at the end of the study as well as changes in SUA levels in comparison to week 0. RESULTS: In both ITT and PP analyses, there were no significant differences in SUA levels or in the changes in SUA levels compared to week 0 between the two groups. However, in a sub-population whose SUA levels at week 0 were within one SD of the mean of the whole PP population, changes in SUA levels in the group consuming PA-3-containing yoghurt were significantly lower than those of the control group (p = .0378). CONCLUSION: PA-3-containing yoghurt improves SUA levels, even in patients with hyperuricaemia and/or gout.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1080/14397595.2018.1442183

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[PMID]: 29358022
[Au] Autor:Lavagnolo MC; Grossule V; Raga R
[Ad] Address:DICEA, Department of Civil, Architectural and Environmental Engineering, University of Padova, Via Marzolo 9, 35131 Padova, Italy.
[Ti] Title:Innovative dual-step management of semi-aerobic landfill in a tropical climate.
[So] Source:Waste Manag;74:302-311, 2018 Apr.
[Is] ISSN:1879-2456
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Despite concerted efforts to innovate the solid waste management (SWM) system, land disposal continues to represent the most widely used technology in the treatment of urban solid waste worldwide. On the other hand, landfilling is an unavoidable step in closing the material cycle, since final residues, although minimized, need to be safely disposed of and confined. In recent years, the implementation of more sustainable landfilling aims to achieve the Final Storage Quality conditions as fast as possible. In particular, semi-aerobic landfill appears to represent an effective solution for use in the poorest economies due to lower management costs and shorter aftercare resulting from aerobic stabilisation of the waste. Nevertheless, the implementation of a semi-aerobic landfill in a tropical climate may affect the correct functioning of the plant: a lack of moisture during the dry season and heavy rainfalls during the wet season could negatively affect performance of both the degradation process, and of leachate and biogas management. This paper illustrates the results obtained through the experimentation of a potential dual-step management of semi-aerobic landfilling in a tropical climate in which composting process was reproduced during the dry season and subsequently flushing (high rainfall rate) during the wet period. Eight bioreactors specifically designed: four operated under anaerobic conditions and four under semi-aerobic conditions; half of the reactors were filled with high organic content waste, half with residual waste obtained following enhanced source segregation. The synergic effect of the subsequent phases (composting and flushing) in the semi-aerobic landfill was evaluated on the basis of both types of waste. Biogas production, leachate composition and waste stabilization were analysed during the trial and at the end of each step, and compared in view of the performance of anaerobic reactors. The results obtained underlined the effectiveness of the dual-step management evidencing how wastes reached a higher degree of stabilization and reference FSQ values for leachate were achieved over a one-year simulation period.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process

  6 / 8474 MEDLINE  
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[PMID]: 29299838
[Au] Autor:Hamuro Y; Coales SJ
[Ad] Address:ExSAR Corporation (scientifically co-founded by Professor Virgil Woods and now dissolved), Monmouth Junction, NJ, USA. yoshitomo.hamuro@sgs.com.
[Ti] Title:Optimization of Feasibility Stage for Hydrogen/Deuterium Exchange Mass Spectrometry.
[So] Source:J Am Soc Mass Spectrom;29(3):623-629, 2018 Mar.
[Is] ISSN:1879-1123
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The practice of HDX-MS remains somewhat difficult, not only for newcomers but also for veterans, despite its increasing popularity. While a typical HDX-MS project starts with a feasibility stage where the experimental conditions are optimized and the peptide map is generated prior to the HDX study stage, the literature usually reports only the HDX study stage. In this protocol, we describe a few considerations for the initial feasibility stage, more specifically, how to optimize quench conditions, how to tackle the carryover issue, and how to apply the pepsin specificity rule. Two sets of quench conditions are described depending on the presence of disulfide bonds to facilitate the quench condition optimization process. Four protocols are outlined to minimize carryover during the feasibility stage: (1) addition of a detergent to the quench buffer, (2) injection of a detergent or chaotrope to the protease column after each sample injection, (3) back-flushing of the trap column and the analytical column with a new plumbing configuration, and (4) use of PEEK (or PEEK coated) frits instead of stainless steel frits for the columns. The application of the pepsin specificity rule after peptide map generation and not before peptide map generation is suggested. The rule can be used not only to remove falsely identified peptides, but also to check the sample purity. A well-optimized HDX-MS feasibility stage makes subsequent HDX study stage smoother and the resulting HDX data more reliable. Graphical Abstract á…Ÿ.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review
[do] DOI:10.1007/s13361-017-1860-3

  7 / 8474 MEDLINE  
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[PMID]: 29514296
[Au] Autor:Olojede OC; Ford MJ; Jacob JP; Ao T; Pescatore AJ; Adedokun SA
[Ad] Address:Department of Animal and Food Sciences, University of Kentucky, Lexington, KY 40546.
[Ti] Title:The effect of drying method temperature, collection method, and marker type on apparent ileal amino acid digestibility in 21-day-old broilers fed corn-soybean meal-barley based diet1.
[So] Source:Poult Sci;, 2018 Mar 05.
[Is] ISSN:1525-3171
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:For accurate estimation of nutrient digestibility, an ideal drying and sampling method is required to preserve the quality of the digesta. A standard corn-soybean meal (corn-SBM) broiler starter diet was fed from d 0 to 10 before birds were placed on the experimental diets until d 21. One hundred and sixty-eight male Cobb 500 broiler chicks were used to evaluate the effect of two drying methods (freeze-dryer vs. forced air-oven) and two drying temperatures (40 vs. 55°C) (Exp 1), while ninety-six chicks were used to evaluate the effect of flushing and squeezing as well as marker types (titanium vs. chromium) on apparent ileal DM, N, Ca, P, and AA digestibility (Exp 2). There were seven (Exp 1) or eight (Exp 2) replicate cages per treatment with 6 birds/cage. Digesta from the distal two thirds of the ileum was obtained from birds following euthanasia on d 21 by squeezing (Exp 1) and squeezing or flushing (Exp 2). Samples collected were stored in the freezer at -20°C until they were either freeze-dried (FD) or oven-dried (OD) at 40 or 55°C. There were no interactions between the drying methods and drying temperatures (Exp 1) on apparent ileal DM, N, and AA digestibility. Met had the highest (92.3%) while Cys had the lowest (73.8%) digestibility value. In Exp 2, no interaction between sampling methods and marker types was observed. The effect of sampling methods was not significant except for Arg and Met where squeezing resulted in higher (P < 0.05) digestibility values. Furthermore, apparent ileal His, Ile, Cys, Ser, and Tyr digestibility tended to be higher (P < 0.1) in squeezed digesta compared to the flushed digesta. Results from these studies showed that OD ileal digesta at 40 or 55°C had no negative effect on apparent ileal AA digestibility. Likewise, marker type did not influence apparent ileal AA digestibility values.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:Publisher
[do] DOI:10.3382/ps/pey049

  8 / 8474 MEDLINE  
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[PMID]: 29513832
[Au] Autor:Pereira JCC; Szpilman D; Haddad Junior V
[Ad] Address:Faculdade de Medicina, Faculdades Pequeno Príncipe, Curitiba, PR, Brasil.
[Ti] Title:Anaphylactic reaction/angioedema associated with jellyfish sting.
[So] Source:Rev Soc Bras Med Trop;51(1):115-117, 2018 Jan-Feb.
[Is] ISSN:1678-9849
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:The most frequent jellyfish in Southern Brazil causes mainly local pain and skin plaques. A 3-year-old female bather presented an erythematous, irregular plaque on the left forearm after contact with a jellyfish and intense facial angioedema with facial flushing. The lungs had vesicular murmur, wheezes, and snorts, and pink and spumous secretion in the airways with intercostal retraction. She was administered subcutaneous adrenaline (0.1mg/kg) and hydrocortisone intravenous (10mg/kg) with total recovery in a few minutes. The manifestations of anaphylactic reactions are distinct from those of envenomations, and prompt and adequate care is fundamental in these situations.
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process

  9 / 8474 MEDLINE  
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[PMID]: 29463464
[Au] Autor:Silva AM; Praxedes ECG; Campos LB; Bezerra LGP; Moreira SSJ; Maia KM; Souza ALP; Silva AR
[Ad] Address:Laboratory of Animal Germplasm Conservation (LCGA), Universidade Federal Rural do Semi-Árido (UFERSA), Mossoró, RN, Brazil.
[Ti] Title:Epididymal sperm from Spix's yellow-toothed cavies sperm successfully cryopreserved in Tris extender with 6% glycerol and 20% egg yolk.
[So] Source:Anim Reprod Sci;191:64-69, 2018 Apr.
[Is] ISSN:1873-2232
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:As a non-threatened hystricognath rodent species, Spix's yellow-toothed cavies can be used as a model for the development of assisted reproductive techniques for the conservation of closely related species. The objective was to establish a functional protocol for cryopreservation of epididymal sperm from these cavies. Twelve sexually mature males, ∼2 y old and weighing ∼300 g, were euthanized. Sperm were recovered by retrograde flushing of the vas deferens and cauda epididymis with Tris extender. Thereafter, sperm were extended in Tris plus 20% egg yolk, with 3%, 6% or 9% glycerol or dimethyl sulfoxide (DMSO), placed in 0.25 mL straws and cryopreserved in liquid nitrogen. Sperm concentration, motility (using computer-assisted sperm analysis; CASA), plasma membrane integrity, osmotic response, morphology and sperm binding-ability were determined in fresh and frozen-thawed sperm. For most sperm endpoints, glycerol was a more desirable cryoprotectant than DMSO. Data (mean ±â€¯SEM) were similar with use of 3%, 6%, and 9% glycerol (P > 0.05) in osmotic response (40.66 ±â€¯6.3%, 42.5 ±â€¯7.1%, and 39.5 ±â€¯5.0% respectably), and membrane integrity (55.17 ±â€¯5.5%, 68.4 ±â€¯4.1%, and 59.1 ±â€¯4.9% respectably). Among concentrations assessed, the use of 6% glycerol resulted in the greatest (P < 0.05) post-thaw values for total motility (60.9 ±â€¯4.4%), rapid subpopulation motility (27.7 ±â€¯3.1%) and sperm-binding capability (227.0 ±â€¯20.2). In conclusion, epididymal sperm from the Spix's yellow-toothed cavies (G. spixii) are optimally cryopreserved in Tris extender with 6% glycerol and 20% egg yolk.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process

  10 / 8474 MEDLINE  
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[PMID]: 29444564
[Au] Autor:Li Y; Bi J; Wang S; Zhang T; Xu X; Wang H; Cheng S; Zhu BW; Tan M
[Ad] Address:School of Food Science and Technology , Dalian Polytechnic University , 1 Qinggongyuan , Ganjingzi District, Dalian , Liaoning 116034 , People's Republic of China.
[Ti] Title:Bio-inspired Edible Superhydrophobic Interface for Reducing Residual Liquid Food.
[So] Source:J Agric Food Chem;66(9):2143-2150, 2018 Mar 07.
[Is] ISSN:1520-5118
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Significant wastage of residual liquid food, such as milk, yogurt, and honey, in food containers has attracted great attention. In this work, a bio-inspired edible superhydrophobic interface was fabricated using U.S. Food and Drug Administration-approved and edible honeycomb wax, arabic gum, and gelatin by a simple and low-cost method. The bio-inspired edible superhydrophobic interface showed multiscale structures, which were similar to that of a lotus leaf surface. This bio-inspired edible superhydrophobic interface displayed high contact angles for a variety of liquid foods, and the residue of liquid foods could be effectively reduced using the bio-inspired interface. To improve the adhesive force of the superhydrophobic interface, a flexible edible elastic film was fabricated between the interface and substrate material. After repeated folding and flushing for a long time, the interface still maintained excellent superhydrophobic property. The bio-inspired edible superhydrophobic interface showed good biocompatibility, which may have potential applications as a functional packaging interface material.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process
[do] DOI:10.1021/acs.jafc.7b05915


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