Database : MEDLINE
Search on : Focal and Epithelial and Hyperplasia [Words]
References found : 1097 [refine]
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[PMID]: 29516939
[Au] Autor:Mattoo A; Bhatia M
[Ad] Address:Department of ENT, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India.
[Ti] Title:Verruca vulgaris of the buccal mucosa: A case report.
[So] Source:J Cancer Res Ther;14(2):454-456, 2018 Jan-Mar.
[Is] ISSN:1998-4138
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Oral verruca vulgaris is caused by human papillomavirus (HPV) infection. Verruca vulgaris most frequently occurs on the fingers, toes, soles, and dorsal surfaces of hands and is mostly asymptomatic. Varieties of verrucous and papillary lesions affect the skin as well as oral mucosa which may be either benign or reactive. Common wart is one of the most commonly observed skin growths and a lesion of childhood. Intraoral warts can occur at any age with equal incidence in both genders but are most commonly seen in the third to fifth decade. It is found commonly on the palate followed by lip, tongue, buccal mucosa, and rarely seen on gingiva. Surgical excision with adequate margins is the treatment of choice.
[Pt] Publication type:LETTER
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Process
[do] DOI:10.4103/jcrt.JCRT_47_17

  2 / 1097 MEDLINE  
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[PMID]: 29513235
[Au] Autor:Carmona Lorduy M; Harris Ricardo J; Hernández Arenas Y; Medina Carmona W
[Ti] Title:Use of trichloroacetic acid for management of oral lesions caused by human papillomavirus.
[So] Source:Gen Dent;66(2):47-49, 2018 Mar-Apr.
[Is] ISSN:0363-6771
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The human papillomavirus (HPV) has an affinity for squamous cells of stratified keratinized epithelium, thus affecting the lower genital, nasal, and oral tracts. In the oral cavity, HPV is associated with pathoses such as the verruca vulgaris (common wart), squamous cell papilloma, condyloma acuminatum (venereal wart), and focal epithelial hyperplasia (Heck disease). Among the treatments available for these lesions are cryotherapy, electrosurgery, surgical removal, laser therapy, and trichloroacetic acid (TCA). The objective of this research was to determine the behavior of HPV-associated oral pathoses treated with TCA. A prospective cohort study was performed in 20 patients who attended a dental consultation at 2 universities in Cartagena, Colombia. Among the patients, 65% were diagnosed as having focal epithelial hyperplasia, 20% as having verrucae vulgares, and 15% as having condylomata acuminata. Application of TCA to HPV-associated oral lesions proved to be a useful nonsurgical alternative treatment, as the resolution of the lesions was achieved atraumatically in a span of 45 days with 3 applications of 30-60 seconds each.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Data-Review

  3 / 1097 MEDLINE  
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[PMID]: 29349786
[Au] Autor:Powell MD; Åtland Å; Dale T
[Ad] Address:Norwegian Institute for Water Research, Bergen, Norway.
[Ti] Title:Acute lion's mane jellyfish, Cyanea capillata (Cnideria: Scyphozoa), exposure to Atlantic salmon (Salmo salar L.).
[So] Source:J Fish Dis;, 2018 Jan 18.
[Is] ISSN:1365-2761
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Jellyfish-induced gill pathology relies upon occasional diagnostic observations yet the extent and impact of jellyfish blooms on aquaculture may be significant. Idiopathic gill lesions are often observed in apparently healthy fish. This study exposed Atlantic salmon (Salmo salar L.) smolts to macerated Cyanea capillata at 2.5 and 5 g/L for 2 hr under controlled laboratory conditions. Blood chemistry and gill histopathology were examined over a subsequent 4-week period. Fish showed an acute response to the presence of jellyfish, including characteristic external "whiplash" discoloration of the skin and acute increases in blood electrolytes and CO concentration; however, these were resolved within 4 days after exposure. Histopathologically, gills showed first an acute oedema with epithelial separation followed by focal haemorrhage and thrombus formation, and then progressive inflammatory epithelial hyperplasia that progressively resolved over the 4 weeks post-exposure. Results were consistent with the envenomation of gills with cytotoxic neurotoxins and haemolysins known to be produced by C. capillata. This study suggests that many focal hyperplastic lesions on gills, especially those involving focal thrombi, may be the result of jellyfish stings. Thus, the presence of jellyfish and their impact may be severe and understated in terms of marine fish aquaculture and fish welfare.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180119
[Lr] Last revision date:180119
[St] Status:Publisher
[do] DOI:10.1111/jfd.12771

  4 / 1097 MEDLINE  
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[PMID]: 29072637
[Au] Autor:Ivina AA; Syomkin VA; Babichenko II
[Ad] Address:Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia; Peoples' Friendship University of Russia, Moscow, Russia.
[Ti] Title:Morfologicheskie osnovy épitelial'no-mezenkhimal'noi transformatsii épiteliia slizistoi obolochki rta pri neoplazii. [Morphology of epithelial-mesenchymal transformation in neoplasias of oral mucosa].
[So] Source:Stomatologiia (Mosk);96(5):11-13, 2017.
[Is] ISSN:0039-1735
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:The aim of the study was to assess correlation of E-cadherin and N-cadherin expression with proliferative activity and neoplasia grade in oral mucosa. Oral biopsies of 48 patients were studied with focal hyperplasia, squamous intraepithelial neoplasia and oral squamous cell carcinoma. Tissue antigens were determined using a mouse monoclonal antibody to Ki-67 and E-cadherin and rabbit polyclonal antibodies to N-cadherin. The study revealed correlation between the proliferative activity of epithelial cells and N-cadherin synthesis associated with decline of E-cadherin expression. Intercellular junction proteins E- and N-cadherins may be used for early diagnosis of malignant transformation of oral squamous epithelium.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171026
[Lr] Last revision date:171026
[St] Status:In-Data-Review
[do] DOI:10.17116/stomat201796511-13

  5 / 1097 MEDLINE  
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[PMID]: 29032114
[Au] Autor:Tepedelen BE; Soya E; Korkmaz M
[Ad] Address:Department of Molecular Biology and Genetic, Faculty of Arts and Science, Uludag University, Bursa 16059, Turkey.
[Ti] Title:Epigallocatechin-3-gallate reduces the proliferation of benign prostatic hyperplasia cells via regulation of focal adhesions.
[So] Source:Life Sci;191:74-81, 2017 Dec 15.
[Is] ISSN:1879-0631
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:AIMS: Benign prostatic hyperplasia (BPH) is the most common urological disease that is characterized by the excessive growth of prostatic epithelial and stromal cells. Pharmacological therapy for BPH has limited use due to the many side effects so there is a need for new agents including natural compounds such as epigallocatechin-3-gallate (EGCG). This study was undertaken to assess the role of EGCG, suppressing the formation of BPH by reducing inflammation and oxidative stress, in cytoskeleton organization and ECM interactions via focal adhesions. MAIN METHODS: We performed MTT assay to investigate cell viability of BPH-1 cells, wound healing assay to examine cell migration, immunofluorescence assay for F-actin organization and paxillin distribution and finally immunoblotting to investigate focal adhesion protein levels in the presence and absence of EGCG. KEY FINDINGS: We found that EGCG inhibits cell proliferation at the concentration of 89.12µM, 21.2µM and 2.39µM for 24, 48 and 72h, respectively as well as inhibitory effects of EGCG on BPH-1 cell migration were observed in a wound healing assay. Furthermore, it was determined by immunofluorescence labeling that EGCG disrupts F-actin organization and reduces paxillin distribution. Additionally, EGCG decreases the activation of FAK (Focal Adhesion Kinase) and the levels of paxillin, RhoA (Ras homolog gene family, member A), Cdc42 (cell division cycle 42) and PAK1 (p21 protein-activated kinase 1) in a dose-dependent manner. SIGNIFICANCE: For the first time, by this study, we found evidence that BPH-1 cell proliferation could be inhibited with EGCG through the disruption of cytoskeleton organization and ECM interactions. Consequently, EGCG might be useful in the prevention and treatment of diseases characterized by excessive cell proliferation such as BPH.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171104
[Lr] Last revision date:171104
[St] Status:In-Process

  6 / 1097 MEDLINE  
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[PMID]: 29026958
[Au] Autor:Özsoy M; Kyriazis I; Vrettos T; Kotsiris D; Ntasiotis P; Seitz C; Evangelos L; Panagiotis K
[Ad] Address:Department of Urology, Medical University of Vienna, Vienna, Austria.
[Ti] Title:Histological changes caused by the prolonged placement of ureteral access sheaths: an experimental study in porcine model.
[So] Source:Urolithiasis;, 2017 Oct 12.
[Is] ISSN:2194-7236
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:The objective is to evaluate the histological damage to the ureteral wall caused by the prolonged placement of an access sheath in porcine model. Six ureters from three female pigs were randomized into three groups. In each group, an UAS with different indwelling time was inserted. 9.5/11.5 Fr Flexor ureteral access sheaths were inserted in both ureters with left indwelling for 30 min and right for 60 min. The ureteral access sheath was advanced up to the proximal ureter. No resistance was observed during the insertion. Ureters were harvested in immediately after the sheath placement process in one pig. The ureters of the remaining two pigs were removed at 1 and 2 weeks after the procedure, respectively. Histological examination took place also in these specimens. Ureters with an indwelling time of 30 min: histological examination of the ureter after immediate dissection revealed signs of acute inflammation at the distal ureter. The ureter dissected at 1 week showed minimal focal transmural inflammation along its length with minimal epithelial hyperplasia. The ureter dissected at 2 weeks, no signs of inflammation. Ureters with an indwelling time of 60 min: histological examination of the immediately dissected ureter revealed signs of acute inflammation at the distal ureter. At 1 week, chronic transmural inflammation was predominantly observed in the distal ureter. At 2 weeks, minimal transmural inflammation was observed. The use of UAS did not cause any severe histological damage on porcine ureters. Acute signs of inflammation gradually recovered within 2 weeks.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171013
[Lr] Last revision date:171013
[St] Status:Publisher
[do] DOI:10.1007/s00240-017-1007-9

  7 / 1097 MEDLINE  
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[PMID]: 28981549
[Au] Autor:Shen AL; Moran SM; Glover EA; Teixeira LB; Bradfield CA
[Ad] Address:The McArdle Laboratory for Cancer Research, Department of Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
[Ti] Title:Retinal pathology in the PPCD1 mouse.
[So] Source:PLoS One;12(10):e0185094, 2017.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Retinal phenotypes of the PPCD1 mouse, a mouse model of posterior polymorphous corneal dystrophy, have been characterized. PPCD1 mice on the DBA/2J background (D2.Ppcd1) have previously been reported to develop an enlarged anterior chamber due to epithelialization and proliferation of the corneal endothelium and subsequent blockage of the iridocorneal angle. Results presented here show that D2.Ppcd1 mice develop increased intraocular pressure (IOP), with measurements at three months of age revealing significant increases in IOP. Significant retinal ganglion cell layer cell loss is observed at five months of age. D2.Ppcd1 animals also exhibit marked degeneration of the outer nuclear layer in association with hyperplasia of the retinal pigment epithelium. Evidence of retinal detachment is present as early as three weeks of age. By 3.5 months of age, focal areas of outer nuclear layer loss are observed. Although the GpnmbR150X mutation leads to increased IOP and glaucoma in DBA/2J mice, development of anterior segment and retinal defects in D2.Ppcd1 animals does not depend upon presence of the GpnmbR150X mutation.
[Mh] MeSH terms primary: Corneal Dystrophies, Hereditary/physiopathology
Retina/pathology
[Mh] MeSH terms secundary: Animals
Corneal Dystrophies, Hereditary/genetics
Intraocular Pressure
Mice
Mice, Inbred DBA
Retinal Detachment/pathology
Retinal Ganglion Cells/pathology
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171026
[Lr] Last revision date:171026
[Js] Journal subset:IM
[Da] Date of entry for processing:171006
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185094

  8 / 1097 MEDLINE  
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[PMID]: 28954044
[Au] Autor:Carrasco AEAB; Machado RS; Patrício FRDS; Kawakami E
[Ad] Address:Disciplina de Gastroenterologia Pediátrica, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
[Ti] Title:HISTOLOGICAL FEATURES OF EOSINOPHILIC ESOPHAGITIS IN CHILDREN AND ADOLESCENTS.
[So] Source:Arq Gastroenterol;54(4):281-285, 2017 Dec.
[Is] ISSN:1678-4219
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:BACKGROUND: Eosinophilic esophagitis is an emerging disease featured by eosinophilic esophageal infiltrate not responsive to proton pump inhibitors. OBJECTIVE: To characterize histological features of children and adolescents with eosinophilic esophagitis. METHODS: Cross-sectional study in a tertiary hospital. Biopsies from each esophageal third from 14 patients (median age 7 years) with eosinophilic esophagitis were evaluated. Histological features evaluated included morphometry of esophageal epithelium, esophageal density (per high power field), extracellular eosinophilic granules, eosinophilic microabscesses, surface disposition of eosinophils, epithelial desquamation, peripapillary eosinophilia, basal layer hyperplasia and papillary elongation. RESULTS: Several patients presented a normal esophageal macroscopy in the upper digestive endoscopy (6, 42.8%), and the most common abnormality were vertical lines (7, 50%) and whitish spots over esophageal mucosa (7, 50%). Basal layer hyperplasia was observed in 88.8%, 100% e 80% of biopsies from proximal, middle and lower esophagus, respectively (P=0.22). Esophageal density ranges from 0 to more than 50 per hpf. Extracellular eosinophilic granules (70%-100%), surface disposition of eosinophils (60%-93%), epithelial desquamation (60%-100%), peripapillary eosinophilia (70%-80%) were common, but evenly distributed among each esophageal third. Just one patient did not present eosinophils in the lower third, four in the middle third and four in the upper esophageal third. CONCLUSION: In the absence of hypereosinophilia, other histological features are present in eosinophilic esophagitis and may contribute to diagnosis. Eosinophilic infiltrate is focal, therefore multiple biopsies are needed for diagnosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171121
[Lr] Last revision date:171121
[St] Status:In-Process

  9 / 1097 MEDLINE  
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[PMID]: 28431210
[Au] Autor:Ruiz CF; Rash JM; Besler DA; Roberts JR; Warren MB; Arias CR; Bullard SA
[Ad] Address:Aquatic Parasitology Laboratory, School of Fisheries, Aquaculture, and Aquatic Sciences and Southeastern Cooperative Fish Parasite and Disease Project (SCFPDL), Auburn University, 203 Swingle Hall, Auburn, Alabama 36849.
[Ti] Title:Exotic "Gill Lice" Species (Copepoda: Lernaeopodidae: Salmincola SPP.) Infect Rainbow Trout (Oncorhynchus mykiss) and Brook Trout (Salvelinus fontinalis) in the Southeastern United States.
[So] Source:J Parasitol;103(4):377-389, 2017 Aug.
[Is] ISSN:1937-2345
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Salmincola californiensis infected 25 of 31 (prevalence 0.8; intensity 2-35 [mean 6.6 ± standard deviation 7.7; n = 25]) rainbow trout, Oncorhynchus mykiss, from a private trout farm connected to the Watauga River, North Carolina. Salmincola edwardsii infected all of 9 (1.0; 2-43 [9.3 ± 13.0; 9]) brook trout, Salvelinus fontinalis, from Big Norton Prong, a tributary of the Little Tennessee River, North Carolina. Both lernaeopodids are well-known salmonid pathogens, but neither is native to, nor has been previously taxonomically confirmed from, the southeastern United States. Herein, we (1) use light and scanning electron microscopy to identify and provide supplemental morphological observations of these lernaeopodids, (2) furnish complementary molecular sequence data from the 28S rDNA (28S), and (3) document the pathological effects of gill infections. We identified and differentiated these lernaeopodids by the second antenna (exopod tip with large [S. californiensis] vs. slender [S. edwardsii] spines; endopod terminal segment with subequal ventral processes shorter than [S. californiensis] vs. longer than or equal to [S. edwardsii] dorsal hook), maxilliped palp (length typically ≤1/3 [S. californiensis] vs. 1/3-1/2 [S. edwardsii] subchela length exclusive of claw), and bulla (sub-circular and concave on manubrium's side [S. californiensis] vs. non-stellate [S. edwardsii]). Analysis of the 28S rDNA sequences confirmed our taxonomic assignments as demonstrated by 100% sequence similarity among the sympatric, morphologically-conspecific isolates. Histopathology revealed focal gill epithelial hyperplasia, obstruction of interlamellar water channels, lamellar fusion, and crypting of gill filaments. High intensity infections by either lernaeopodid are surveillance-worthy because they are potentially pathogenic to trout in the southeastern United States.
[Mh] MeSH terms primary: Copepoda/classification
Ectoparasitic Infestations/veterinary
Fish Diseases/parasitology
Gills/parasitology
Oncorhynchus mykiss/parasitology
Trout/parasitology
[Mh] MeSH terms secundary: Animals
Copepoda/genetics
Copepoda/ultrastructure
DNA, Ribosomal/chemistry
DNA, Ribosomal/isolation & purification
Ectoparasitic Infestations/epidemiology
Ectoparasitic Infestations/parasitology
Ectoparasitic Infestations/pathology
Female
Fish Diseases/epidemiology
Fish Diseases/pathology
Fisheries
Gills/pathology
Gills/ultrastructure
Microscopy, Electron, Scanning
Prevalence
RNA, Ribosomal, 28S/genetics
Rivers
Southeastern United States/epidemiology
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (DNA, Ribosomal); 0 (RNA, Ribosomal, 28S)
[Em] Entry month:1708
[Cu] Class update date: 170818
[Lr] Last revision date:170818
[Js] Journal subset:IM
[Da] Date of entry for processing:170422
[St] Status:MEDLINE
[do] DOI:10.1645/16-165

  10 / 1097 MEDLINE  
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[PMID]: 28375585
[Au] Autor:Chen P; Lei L; Wang J; Zou X; Zhang D; Deng L; Wu D
[Ad] Address:Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
[Ti] Title:Downregulation of Talin1 promotes hepatocellular carcinoma progression through activation of the ERK1/2 pathway.
[So] Source:Cancer Sci;108(6):1157-1168, 2017 Jun.
[Is] ISSN:1349-7006
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Talin1 is an adaptor protein that conjugates integrins to the cytoskeleton and regulates integrins and focal adhesion signaling. Several studies have found that Talin1 is overexpressed in several tumor types and promotes tumor progression. However, the explicit role of Talin1 in hepatocellular carcinoma (HCC) progression is still unclear and its functional mechanism remains largely unknown. In this study, we showed a trend of gradually decreasing expression of Talin1 from normal liver tissues to hepatocirrhosis, liver hyperplasia, the corresponding adjacent non-tumor, primary HCC, and eventually metastatic foci, indicating that Talin1 may correlate with HCC initiation to progression. Talin1 was significantly downregulated in HCC tissues compared with adjacent non-tumor tissues and low Talin1 expression was associated with HCC progression and poor prognosis. Furthermore, Talin1 knockdown induced epithelial-mesenchymal transition and promoted migration and invasion in SK-Hep-1 cells and HepG2 cells. Mechanistically, we found that the ERK pathway was responsible for these promoting effects of Talin1 knockdown in HCC cells. The promoting effects of Talin1 knockdown on epithelial-mesenchymal transition, migration, and invasion were reversed by U0126, a specific ERK1/2 inhibitor. Taken together, our results suggested that Talin1 might serve as a tumor suppressor in HCC and a potential prognostic biomarker for HCC patients.
[Mh] MeSH terms primary: Carcinoma, Hepatocellular/genetics
Carcinoma, Hepatocellular/pathology
Down-Regulation/genetics
Liver Neoplasms/genetics
Liver Neoplasms/pathology
MAP Kinase Signaling System/genetics
Talin/genetics
[Mh] MeSH terms secundary: Cell Line
Cell Line, Tumor
Cell Movement/genetics
Disease Progression
Epithelial-Mesenchymal Transition/genetics
Female
Gene Expression Regulation, Neoplastic/genetics
Hep G2 Cells
Humans
Male
Middle Aged
Signal Transduction/genetics
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (TLN1 protein, human); 0 (Talin)
[Em] Entry month:1709
[Cu] Class update date: 170915
[Lr] Last revision date:170915
[Js] Journal subset:IM
[Da] Date of entry for processing:170405
[St] Status:MEDLINE
[do] DOI:10.1111/cas.13247


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