Database : MEDLINE
Search on : Furazolidone [Words]
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[PMID]: 29480532
[Au] Autor:Zhuge L; Wang Y; Wu S; Zhao RL; Li Z; Xie Y
[Ad] Address:Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
[Ti] Title:Furazolidone treatment for Helicobacter Pylori infection: A systematic review and meta-analysis.
[So] Source:Helicobacter;, 2018 Feb 26.
[Is] ISSN:1523-5378
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Antibiotic resistance is a major cause of Helicobacter pylori (H. pylori) treatment failures. Because the resistance rate of H. pylori to furazolidone is low, we aimed to assess the efficacy and safety of furazolidone. We searched the PubMed, Web of Science, Cochrane Library, and Embase databases and included randomized controlled trials (RCT) that either compared furazolidone to other antibiotics or changed the administered dose of furazolidone. A total of 18 articles were included in the meta-analysis. According to the intention-to-treat (ITT) analysis, the total eradication rates of furazolidone-containing therapy were superior to those of other antibiotic-containing therapies (relative risk [RR] 1.07, 95% confidence interval [CI] 1.01-1.14) (13 RCTs). Specifically, the eradication rates of furazolidone-containing therapy were better than those for metronidazole-containing therapy (RR 1.10, 95% CI: 1.01-1.21 for ITT). The eradication rate of furazolidone-containing bismuth-containing quadruple therapy was 92.9% (95% CI: 90.7%-95.1%) (PP). In addition, a higher daily dose of furazolidone increased the eradication rate (RR 1.17, 95% CI: 1.05-1.31). And the incidence of some adverse effects, such as fever and anorexia, was higher in the furazolidone group than in the control group, the overall incidences of total side effects and severe side effects showed no significant differences between the groups. Furazolidone-containing treatments could achieve satisfactory eradication rates and did not increase the incidence of total or severe adverse effects, but the incidence of milder side effects, such as fever and anorexia, should be considered when prescribing furazolidone-containing treatments to patients.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[St] Status:Publisher
[do] DOI:10.1111/hel.12468

  2 / 1613 MEDLINE  
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[PMID]: 29437629
[Au] Autor:Otta DA; de Araújo FF; de Rezende VB; Souza-Fagundes EM; Elói-Santos SM; Costa-Silva MF; Santos RA; Costa HA; Siqueira Neto JL; Martins-Filho OA; Teixeira-Carvalho A
[Ad] Address:Grupo Integrado de Pesquisas em Biomarcadores, Instituto René Rachou, Fundação Oswaldo Cruz-FIOCRUZ, Belo Horizonte, Minas Gerais, Brazil.
[Ti] Title:Identification of Anti- Lead Compounds with Putative Immunomodulatory Activity.
[So] Source:Antimicrob Agents Chemother;, 2018 Feb 05.
[Is] ISSN:1098-6596
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:In substitution for the current Chagas disease treatment with several relevant side effects, new therapeutic candidates have been extensively investigated. In this context, the balanced interaction between mediators of the host immune response seems to be a key element for therapeutic success, where a pro-inflammatory microenvironment modulated by IL-10 is shown to be relevant to potentiate anti- drug activity. This study aimed to identify the potential immunomodulatory activity of the anti- K777, Pyronaridine (PYR) and Furazolidone (FUR) compounds in peripheral blood mononuclear cells (PBMC) from noninfected subjects (NI) and chronic Chagas disease patients (CD). Our results showed low cytotoxicity to PBMC populations, with CC = 13.1µM (K777); 9.0µM (PYR) and greater than 20µM (FUR). In addition, K777 showed no impact on the exposure index (EI) of phytohemagglutinin-stimulated leukocytes (PHA), while PYR and FUR treatments induced increased EI of monocytes and T lymphocytes at late stages of apoptosis in NI subjects. Moreover, K777 induced a more prominent pro-inflammatory response (TNF-α CD8 /CD4 , IFN-γ CD4 /CD8 modulated by IL-10 (IL-10 CD4 T/CD8 T) in comparison with PYR (TNF-α CD8 , IL-10 CD8 ) and FUR (TNF-α CD8 , IL-10 CD8 ). Signature analysis of intracytoplasmic cytokines corroborated with the proinflammatory/modulated (K777) and pro-inflammatory (PYR and FUR) profiles previously found. In conclusion, K777 lead compound may induce beneficial changes in the immunological profile of patients presenting the chronic phase of Chagas disease and may contribute to a more effective therapy against the disease.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[St] Status:Publisher

  3 / 1613 MEDLINE  
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[PMID]: 29279443
[Au] Autor:Pal BB; Nayak SR; Khuntia HK
[Ad] Address:Microbiology Division, Regional Medical Research Centre (ICMR).
[Ti] Title:Epidemiology and antibiogram profile of Vibrio cholerae isolates between 2004-2013 from Odisha, India.
[So] Source:Jpn J Infect Dis;, 2017 Dec 26.
[Is] ISSN:1884-2836
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:Cholera is an acute diarrhoeal disease caused by Vibrio cholerae O1 and O139 serogroups which are known to cause epidemics of cholera in Odisha. The present study has been envisaged to document the antibiotic resistance pattern among clinical isolates of both serogroups of V.cholerae O1 and O139 isolated during 2004-2013. Nine hundred nine isolates of V.cholerae were included in this study which were identified by standard procedures. Antibiotic sensitivity test was performed by disc diffusion method. The seasonality of cholera in this region indicated that there was one peak observed in the rainy season only. The cholera cases started increasing from the month of July and declined from the month of October onwards. The adult age group of patients were worst affected among all age group of patients. The two different serogroups of V.cholerae O1 and O139 showed different percentage of resistance to all the antibiotics in each year. The serogroup O1 showed uniform high resistance to co-trimoxazole, furazolidone, nalidixic acid throughout the study. Chloramphenicol showed resistance only during 2009, whereas it was sensitive for rest of the years. The emergence of multiple drug resistant V.cholerae may significantly influence the control of future outbreaks and epidemics of cholera in this region.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171227
[Lr] Last revision date:171227
[St] Status:Publisher
[do] DOI:10.7883/yoken.JJID.2017.193

  4 / 1613 MEDLINE  
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[PMID]: 29178873
[Au] Autor:Zhou Z; Zhang M; Li H; Yang H; Li X; Song X; Wang Z
[Ad] Address:College of Animal Science, Rongchang Campus of Southwest University, No. 160 Xueyuan Road, Rongchang District, Chongqing, 402460, China. zzyxnny@163.com.
[Ti] Title:Prevalence and molecular characterization of Staphylococcus aureus isolated from goats in Chongqing, China.
[So] Source:BMC Vet Res;13(1):352, 2017 Nov 25.
[Is] ISSN:1746-6148
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Staphylococcus aureus is an important zoonotic pathogen which not only causes significant economic loss in livestock production but also poses a potential threat to public health. Compared with bovine and swine, the information on the colonization of S. aureus in goats is very limited. To understand the prevalence and characteristics of S. aureus in goats, we used the nasal swabs collected from apparently healthy goats to isolate S. aureus, and tested their antimicrobial susceptibility, virulence gene carrying levels, and multilocus sequence typing (MLST). RESULTS: In 74 nasal swabs of apparently healthy goats, 32 (43.24%) S. aureus strains were isolated and identified, most of which were susceptible to many antibiotics, except for trimethoprim, furazolidone, amoxicillin, lincomycin and roxithromycin, and the resistance incidence of which were 50%, 40.63%, 37.5%, 28.13%, and 21.88% respectively. All the isolates were methicillin-susceptible S. aureus (MSSA) and mecA-negative. Enterotoxin genes were found in 53.13% of the strains. Of which, sej was the most prevalent (21.88%), followed by seb, sec, and see with the same level (18.75%). The most prevalent combination were seb + see and seb + tst. None of the S. aureus isolates harbored sea, sed, seh, eta and etb. Multilocus sequence typing (MLST) revealed 6 new alleles (aroe-552, aroe-553, glpf-500, pta-440, yqil-482 and yqil-496) and 5 new sequence types (STs) (3431,3440,3444,3445 and 3461). Using eBURST, the 5 STs were assigned to clonal complex 522 (CC522) and a further CC with no predicted ancestor. Phylogenetic analysis of seven concatenated MLST alleles revealed that the 5 STs were grouped into cluster I composed of S. aureus mainly from goats and sheep. CONCLUSION: We provide the data for prevalence of S. aureus in goats in Chongqing municipality and their characterization which will help in tracking evolution of epidemic strains and their control methods.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171219
[Lr] Last revision date:171219
[St] Status:In-Process
[do] DOI:10.1186/s12917-017-1272-4

  5 / 1613 MEDLINE  
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[PMID]: 29227738
[Au] Autor:Yousefi-Avarvand A; Vaez H; Tafaghodi M; Sahebkar AH; Arzanlou M; Khademi F
[Ad] Address:1 Department of Medical Bacteriology and Virology, School of Medicine, Mashhad University of Medical Sciences , Mashhad, Iran .
[Ti] Title:Antibiotic Resistance of Helicobacter pylori in Iranian Children: A Systematic Review and Meta-Analysis.
[So] Source:Microb Drug Resist;, 2017 Dec 11.
[Is] ISSN:1931-8448
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Antibiotic therapy for children infected with Helicobacter pylori is important. However, resistance to antibiotics is one of the main causes of treatment failure. This study was designed to evaluate the prevalence pattern of antibiotic resistance of H. pylori in Iranian children using a systematic review and meta-analysis of literature. A computerized search (until June 10, 2017) using related keywords in the national and international databases was performed. A total of 261 original articles on antibiotic resistance of H. pylori in Iranian children were collected. After screening for inclusion and exclusion criteria, six eligible articles were included in the meta-analysis. Resistance rates of H. pylori to different antibiotics were as follows: metronidazole: 71%, clarithromycin: 12.2%, amoxicillin: 20.4%, tetracycline: 8.4%, ampicillin: 21.4%, rifampin: 28.6%, furazolidone: 8.4%, ciprofloxacin: 16.2%, azithromycin: 19%, erythromycin: 15.3%, and nitrofurantoin: 0%. The prevalence of H. pylori resistance to metronidazole, amoxicillin, ampicillin, and rifampin among Iranian children was high. Therefore, a careful monitoring of antibiotic resistance to select the best treatment options and prevent treatment failure is required. Although resistance to some antibiotics such as clarithromycin, tetracycline, furazolidone, and ciprofloxacin was less prevalent, frequent consumption of these drugs in children should be controlled owing to their known adverse events.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171211
[Lr] Last revision date:171211
[St] Status:Publisher
[do] DOI:10.1089/mdr.2017.0292

  6 / 1613 MEDLINE  
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[PMID]: 29138101
[Au] Autor:Liu DS; Wang YH; Zeng ZR; Zhang ZY; Lu H; Xu JM; Du YQ; Li Y; Wang JB; Xu SP; Chen Y; Lan CH; Cheng H; Jiang MD; Zhang LX; Huo LJ; Chen SY; Zhang GX; Wu KC; Zhu X; Chen YX; Zhu Y; Shu X; Xie Y; Lu NH
[Ad] Address:Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
[Ti] Title:Primary antibiotic resistance of Helicobacter pylori in Chinese patients: A multi-region prospective 7-year study.
[So] Source:Clin Microbiol Infect;, 2017 Nov 11.
[Is] ISSN:1469-0691
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVES: To explore the characteristics of H. pylori resistance in China and the association between antibiotic resistance and several clinical factors. METHODS: H. pylori strains were collected from patients in 13 provinces/cities in China between 2010 and 2016. Demographic data including type of disease, geographic area, age, gender and isolation year were collected to analyse their association with antibiotic resistance. Antibiotic resistance was detected using the Epsilometer test and the Kirby-Bauer disk diffusion method. RESULTS: H. pylori were successfully cultured from 1117 patients. The prevalence of metronidazole, clarithromycin, azithromycin, levofloxacin, moxifloxacin, amoxicillin, tetracycline and rifampicin resistance was 78.2, 22.1, 23.3, 19.2, 17.2, 3.4, 1.9 and 1.5%, respectively. No resistance to furazolidone was observed. The resistance rates to levofloxacin and moxifloxacin were higher in strains isolated from patients with gastritis compared to those with duodenal ulcer and among women. Compared with patients ≥40 years old, younger patients exhibited lower resistance rates to clarithromycin, azithromycin, levofloxacin and moxifloxacin. The resistance rates to clarithromycin and amoxicillin were higher in strains isolated more recently, and we also found that the prevalence of resistance to metronidazole, clarithromycin, azithromycin and amoxicillin were significantly different among different regions of China. CONCLUSIONS: The resistance rates to metronidazole, clarithromycin, levofloxacin were high in China. Patient age, gender, disease and location were associated with the resistance of H. pylori to some antibiotics. Furazolidone, amoxicillin and tetracycline are better choices for H. pylori treatment in China.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171115
[Lr] Last revision date:171115
[St] Status:Publisher

  7 / 1613 MEDLINE  
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[PMID]: 29093585
[Au] Autor:Barreda Costa CS; Barriga Briceño JA; Piccini Larco JR
[Ad] Address:Servicio de Gastroenterología, Clínica Ricardo Palma. Lima, Perú.
[Ti] Title:Efectividad de un nuevo régimen simplificado en la erradicación de Helicobacter pylori. Estudio prospectivo realizado en una clínica privada de Lima Metropolitana. [New simplified regimen for Helicobacter pylori eradication achieves high effectiveness. Prospective study in a private clinic in Lima, Peru].
[So] Source:Rev Gastroenterol Peru;37(3):225-230, 2017 Jul-Sep.
[Is] ISSN:1609-722X
[Cp] Country of publication:Peru
[La] Language:spa
[Ab] Abstract:OBJECTIVE: To determine the effectiveness of two new therapeutic regimes for Helicobacter pylori versus triple therapy that includes a proton pump inhibitor, amoxicillin and clarithromycin. MATERIALS AND METHODS: prospective study, non-randomized, in a private Hospital in Lima, Peru. Patients with biopsy and/or rapid ureasa test proven Helicobacter pylori infection received one of the three therapeutic regimens and were followed with a urea breath test 1 to 6 months upon completion of therapy. RESULTS: Triple therapy achieved eradication in 49/68 of cases (71.2%); quadruple therapy (doxycycline + metronidazole + bismuth + esomeprazole) in 52/62 (83.9%), and the simplified regimen with doxycycline + furazolidone + bismuth, obtained success in 79/83 of cases (95.2%). Statistically significant difference with p<0.005 and p<0.05 respectively. CONCLUSION: Triple therapy against Hp does not achieve acceptable effectiveness in our institution. This highlights the need to look for new therapeutic options, being the simplified regime (doxycycline, furazolidone and bismuth) used in the current study a good option, requiring further studies for validation.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171102
[Lr] Last revision date:171102
[St] Status:In-Process

  8 / 1613 MEDLINE  
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[PMID]: 29085236
[Au] Autor:Zamani M; Rahbar A; Shokri-Shirvani J
[Ad] Address:Student Research Committee, Babol University of Medical Sciences, Babol 47176-47745, Iran.
[Ti] Title:Resistance of to furazolidone and levofloxacin: A viewpoint.
[So] Source:World J Gastroenterol;23(37):6920-6922, 2017 Oct 07.
[Is] ISSN:2219-2840
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:In their review, Arslan et al did not describe the status of ( ) treatment with furazolidone and the resistance to this antibiotic. We have presented different surveys showing the resistance of to furazolidone from Asia and South America. The resistance rates varied but were mostly low (< 5%). There are not enough data on its efficacy and resistance in the United States and Europe. mutations occurring in the gene, including A041G, A122G, C349A(G), A78G, A112G, A335G, C156T and C165T, and in the gene, including G353A, A356G, C357T, C347T, C347G and C346A, have been indicated to be possibly related to the observed resistance. Additionally, to complete Arslan et al's statement regarding levofloxacin resistance, it should be noted that compound mutations of N87A, A88N and V65I at codon Asn-87 were recently observed in the gene for the first time. However, the results on these topics are not sufficient, and more worldwide studies are suggested.
[Mh] MeSH terms primary: Furazolidone
Levofloxacin
[Mh] MeSH terms secundary: Asia
Drug Resistance, Bacterial/genetics
Europe
Helicobacter Infections
Helicobacter pylori/genetics
Microbial Sensitivity Tests
[Pt] Publication type:JOURNAL ARTICLE; COMMENT
[Nm] Name of substance:5J9CPU3RE0 (Furazolidone); 6GNT3Y5LMF (Levofloxacin)
[Em] Entry month:1711
[Cu] Class update date: 171102
[Lr] Last revision date:171102
[Js] Journal subset:IM
[Da] Date of entry for processing:171101
[St] Status:MEDLINE
[do] DOI:10.3748/wjg.v23.i37.6920

  9 / 1613 MEDLINE  
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[PMID]: 28984385
[Au] Autor:Shao Y; Lu R; Yang Y; Xu Q; Wang B; Ye G
[Ad] Address:Department of Gastroenterology, the Affiliated Hospital of Ningbo University School of Medicine, Ningbo, China.
[Ti] Title:Antibiotic resistance of Helicobacter pylori to 16 antibiotics in clinical patients.
[So] Source:J Clin Lab Anal;, 2017 Oct 06.
[Is] ISSN:1098-2825
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Resistance of Helicobacter pylori (H. pylori) to antibiotics is increasing worldwide. To determine the status of H. pylori resistance and its patterns in clinical patients, an investigation utilizing susceptibility testing for commonly used antibiotics was needed. METHODS: Total of 2283 H. pylori strains were collected from 2013 to 2016. The resistance and its patterns of these strains were tested by agar dilution method. The resistance rate and minimal inhibition concentration (MIC) in different gender groups were also analyzed. RESULTS: The overall resistance rates were as following: amoxicillin (1.58%), clarithromycin (22.73%), levofloxacin (24.75%), furazolidone (1.49%), doxycycline (9.20%), cefetamet (97.20%), ceftriaxone (49.60%), cefuroxime (25.20%), gentamicin (3.73%), azithromycin (85.60%), rifampicin (2.80%), metronidazole (92.53%), ornidazole (94.27%), tinidazole (87.20%), ciprofloxacin (43.20%), and moxifloxacin (38.53%). There were only 64.08% strains pan-susceptible to amoxicillin, clarithromycin, levofloxacin, and furazolidone, followed by mono resistance (23.17%), double resistance (11.13%), triple resistance (1.36%), and quadruple resistance (0.26%). Significant differences in the resistance rate and MIC were also observed in different gender groups. CONCLUSION: Antibiotic resistance trends of H. pylori is increasing in clinical patients. With the increasing resistance, it is imperative to individualized therapy based on the results of drug susceptibility testing.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171006
[Lr] Last revision date:171006
[St] Status:Publisher
[do] DOI:10.1002/jcla.22339

  10 / 1613 MEDLINE  
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[PMID]: 28910741
[Au] Autor:Leitsch D
[Ad] Address:Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Kinderspitalgasse 15, A-1095 Vienna, Austria. Electronic address: david.leitsch@meduniwien.ac.at.
[Ti] Title:Drug susceptibility testing in microaerophilic parasites: Cysteine strongly affects the effectivities of metronidazole and auranofin, a novel and promising antimicrobial.
[So] Source:Int J Parasitol Drugs Drug Resist;7(3):321-327, 2017 Sep 05.
[Is] ISSN:2211-3207
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The microaerophilic parasites Entamoeba histolytica, Trichomonas vaginalis, and Giardia lamblia annually cause hundreds of millions of human infections which are treated with antiparasitic drugs. Metronidazole is the most often prescribed drug but also other drugs are in use, and novel drugs with improved characteristics are constantly being developed. One of these novel drugs is auranofin, originally an antirheumatic which has been relabelled for the treatment of parasitic infections. Drug effectivity is arguably the most important criterion for its applicability and is commonly assessed in susceptibility assays using in vitro cultures of a given pathogen. However, drug susceptibility assays can be strongly affected by certain compounds in the growth media. In the case of microaerophilic parasites, cysteine which is added in large amounts as an antioxidant is an obvious candidate because it is highly reactive and known to modulate the toxicity of metronidazole in several microaerophilic parasites. In this study, it was attempted to reduce cysteine concentrations as far as possible without affecting parasite viability by performing drug susceptibility assays under strictly anaerobic conditions in an anaerobic cabinet. Indeed, T. vaginalis and E. histolytica could be grown without any cysteine added and the cysteine concentration necessary to maintain G. lamblia could be reduced to 20%. Susceptibilities to metronidazole were found to be clearly reduced in the presence of cysteine. With auranofin the protective effect of cysteine was extreme, providing protection to concentrations up to 100-fold higher as observed in the absence of cysteine. With three other drugs tested, albendazole, furazolidone and nitazoxanide, all in use against G. lamblia, the effect of cysteine was less pronounced. Oxygen was found to have a less marked impact on metronidazole and auranofin than cysteine but bovine bile which is standardly used in growth media for G. lamblia, displayed a marked synergistic effect with metronidazole.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170922
[Lr] Last revision date:170922
[St] Status:Publisher


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