Database : MEDLINE
Search on : Furunculosis [Words]
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[PMID]: 29498111
[Au] Autor:Mosca M; Vabret M; Randleff-Rasmussen P; Pin D
[Ad] Address:UP Interactions Cellules Environnement, VetAgro Sup, Université de Lyon, 1 Avenue Bourgelat, 69280, Marcy l'Etoile, France.
[Ti] Title:Skin lesions in Aubrac cows strongly associated with fly bites (Haematobia irritans).
[So] Source:Vet Dermatol;, 2018 Mar 01.
[Is] ISSN:1365-3164
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: The horn fly Haematobia irritans is known to cause problems in cattle including weight loss and decreased milk production; cutaneous lesions have not been widely reported and descriptions of the clinical manifestations are quite variable. HYPOTHESIS/OBJECTIVES: This study describes the clinical and histopathological lesions of several Aubrac cows that presented with focal to confluent areas of alopecia, skin scaling and thickening, suspected to be induced by H. irritans bites. ANIMALS: Twenty seven, three- to six-year-old Aubrac cows, kept in mountain pastures in France, that presented with an apparently asymptomatic alopecic dermatosis. METHODS: Samples for skin cytological evaluation, skin scrapings and trichograms were examined; also, skin biopsy specimens from affected animals were used for histopathological examination. RESULTS: Clinical lesions consisted of focal to coalescing, symmetrical areas of hair loss and scaling, located on the back, flanks, and lateral and caudal aspects of the thighs. Histopathological examination revealed perivascular, oedematous, eosinophilic dermatitis with eosinophilic folliculitis and furunculosis. Species identification of several flies captured on the cows revealed H. irritans. The final clinicopathological diagnosis was eosinophilic dermatitis and folliculitis and furunculosis, suspected to be due to H. irritans fly-bite. CONCLUSION AND CLINICAL IMPORTANCE: Fly-bite (H. irritans) dermatitis should be included in the differential diagnosis of alopecic dermatoses in cows.
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:Publisher
[do] DOI:10.1111/vde.12530

  2 / 1150 MEDLINE  
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[PMID]: 29236652
[Au] Autor:Bakshi SS
[Ad] Address:Associate Professor of Otolaryngology in the Department of Ear, Nose, and Throat and Head and Neck Surgery at Mahatma Gandhi Medical College and Research Institute in Pillaiyarkuppam, Pondicherry, India. saty.bakshi@gmail.com.
[Ti] Title:Image Diagnosis: Nasal Furunculosis-A Dangerous Nose Infection.
[So] Source:Perm J;22, 2017.
[Is] ISSN:1552-5775
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180103
[Lr] Last revision date:180103
[St] Status:In-Process
[do] DOI:10.7812/TPP/17-076

  3 / 1150 MEDLINE  
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[PMID]: 29236128
[Au] Autor:Nowicka D; Grywalska E; Fitas E; Mielnik M; Rolinski J
[Ad] Address:Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Chalubinskiego 1, 50-368, Wroclaw, Poland. danuta.nowicka@umed.wroc.pl.
[Ti] Title:NK and NKT-Like Cells in Patients with Recurrent Furunculosis.
[So] Source:Arch Immunol Ther Exp (Warsz);, 2017 Dec 13.
[Is] ISSN:1661-4917
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:To analyze changes in the number and percentage of NK and NKT-like cells in relation to other immune cells as well as to examine associations between increased susceptibility to infections and NK and NKT-like status in patients with recurrent furunculosis (RF) and healthy controls. Thirty patients with RF and 20 healthy age- and sex-matched volunteers were recruited. Blood samples were examined. Lymphocyte count and cytometric analyses were conducted. For statistical analysis, the Student's t test, F test, and Brown-Forsythe test were used for comparison between groups of variables. Associations were assessed with Pearson coefficient. Patients with RF had lower lymphocyte count than controls. Additionally, they presented with the following changes in the blood picture: a significant increase in the number of NK cells with a CD3 CD16 CD56 phenotype; a proportional increase in the number and percentage of NKT-like cells with a CD3 CD16 CD56 phenotype; a significant decrease in the number and percentage of T CD3 cells. The number of NK cells was strongly positively correlated with the number of CD3 cells (r = 0.6162). The number of NKT cells was strongly positively correlated with CD3 cells (r = 0.6885) and CD3CD8 cells (r = 0.5465). Periodic exacerbations in RF are associated with the development of furuncles, which are a result of many already discovered as well as just being examined mechanisms. One of them is a significant increase in the number and most likely activation of NK and NKT-like cells during the formation of the inflammatory process and furuncles.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171213
[Lr] Last revision date:171213
[St] Status:Publisher
[do] DOI:10.1007/s00005-017-0500-8

  4 / 1150 MEDLINE  
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[PMID]: 29149266
[Au] Autor:Malik U; Armstrong D; Ashworth M; Dregan A; L'Esperance V; McDonnell L; Molokhia M; White P
[Ad] Address:Department of Primary Care and Public Health Sciences, King's College London, Addison House, Guy's Campus, London SE1 1UL, UK.
[Ti] Title:Association between prior antibiotic therapy and subsequent risk of community-acquired infections: a systematic review.
[So] Source:J Antimicrob Chemother;, 2017 Nov 14.
[Is] ISSN:1460-2091
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Background: Antibiotic use can have negative unintended consequences including disruption of the human microbiota, which is thought to protect against pathogen overgrowth. We conducted a systematic review to assess whether there is an association between exposure to antibiotics and subsequent risk of community-acquired infections. Methods: We searched MEDLINE, EMBASE and Web of Science for studies published before 30 June 2017, examining the association between antibiotic use and subsequent community-acquired infection. Infections caused by Clostridium difficile and fungal organisms were excluded. Studies focusing exclusively on resistant organism infections were also excluded. Results: Eighteen of 22 588 retrieved studies met the inclusion criteria. From these, 16 studies reported a statistically significant association between antibiotic exposure and subsequent risk of community-acquired infection. Infections associated with prior antibiotic use included Campylobacter jejuni infection (one study), recurrent furunculosis (one study), invasive Haemophilus influenzae type b infection (one study), infectious mastitis (one study), meningitis (one study), invasive pneumococcal disease (one study), Staphylococcus aureus skin infection (one study), typhoid fever (two studies), recurrent boils and abscesses (one study), upper respiratory tract infection and urinary tract infection (one study) and Salmonella infection (five studies), although in three studies on Salmonella infection the effect was of marginal statistical significance. Conclusions: We found an association between prior antibiotic use and subsequent risk of a diverse range of community-acquired infections. Gastrointestinal and skin and soft tissue infections were most frequently found to be associated with prior antibiotic exposure. Our findings support the hypothesis that antibiotic use may predispose to future infection risk, including infections caused by both antibiotic-resistant and non-resistant organisms.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171117
[Lr] Last revision date:171117
[St] Status:Publisher
[do] DOI:10.1093/jac/dkx374

  5 / 1150 MEDLINE  
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[PMID]: 28765570
[Au] Autor:Vincent AT; Paquet VE; Bernatchez A; Tremblay DM; Moineau S; Charette SJ
[Ad] Address:Institut de Biologie Intégrative et des Systèmes (IBIS), Université Laval, Quebec City, QC, G1V 0A6, Canada.
[Ti] Title:Characterization and diversity of phages infecting Aeromonas salmonicida subsp. salmonicida.
[So] Source:Sci Rep;7(1):7054, 2017 Aug 01.
[Is] ISSN:2045-2322
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Phages infecting Aeromonas salmonicida subsp. salmonicida, the causative agent of the fish disease furunculosis, have been isolated for decades but very few of them have been characterized. Here, the host range of 12 virulent phages, including three isolated in the present study, was evaluated against a panel of 65 A. salmonicida isolates, including representatives of the psychrophilic subspecies salmonicida, smithia, masoucida, and the mesophilic subspecies pectinolytica. This bacterial set also included three isolates from India suspected of being members of a new subspecies. Our results allowed to elucidate a lytic dichotomy based on the lifestyle of A. salmonicida (mesophilic or psychrophilic) and more generally, on phage types (lysotypes) for the subspecies salmonicida. The genomic analyses of the 12 phages from this study with those available in GenBank led us to propose an A. salmonicida phage pan-virome. Our comparative genomic analyses also suggest that some phage genes were under positive selection and A. salmonicida phage genomes having a discrepancy in GC% compared to the host genome encode tRNA genes to likely overpass the bias in codon usage. Finally, we propose a new classification scheme for A. salmonicida phages.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170927
[Lr] Last revision date:170927
[St] Status:In-Data-Review
[do] DOI:10.1038/s41598-017-07401-7

  6 / 1150 MEDLINE  
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[PMID]: 28730424
[Au] Autor:Nowicka D; Grywalska E; Hymos A; Mielnik M; Rolinski J
[Ad] Address:Department of Dermatology, Venereology and Allergology, Medical University of Wroclaw, Chalubinskiego 1, 50-368, Wroclaw, Poland. Danuta.Nowicka@Umed.Wroc.Pl.
[Ti] Title:Possible Immunomodulating Effect of Retinol on Cytokines Secretion in Patients with Recurrent Furunculosis.
[So] Source:Arch Immunol Ther Exp (Warsz);, 2017 Jul 20.
[Is] ISSN:1661-4917
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Recurrent furunculosis is an infection of hair follicles which results in formation of abscesses. Previous studies showed that the pathogenesis of the disease may include an immune-mediated component as the proliferative response of peripheral blood lymphocytes to staphylococcal antigen is depressed. The aim of our study was to evaluate cytokines concentration in the plasma of patients with recurrent furunculosis and to determine whether retinol affects the secretion of those cytokines in patients with recurrent furunculosis and healthy subjects. Blood samples were taken from 15 patients with recurrent furunculosis and 15 age-matched healthy subjects. A quantitative determination of selected cytokines (IL-17, 13, 2, 10, 4, IFN-γ, TNF-α) was performed in the plasma at baseline and after 72-h culture of peripheral blood mononuclear cells with and without retinol in both groups. In the plasma of patients with recurrent furunculosis, concentration of IL-10, 2, and TNF-α was significantly higher, whereas IL-13 significantly lower when compared with healthy subjects. After retinol stimulation, the concentration of IL-17 and IFN-γ increased significantly in both groups. Secretion of anti-inflammatory cytokines, especially IL-10 (p < 0.002) and 13 (p < 0.01), achieved lower levels in recurrent furunculosis samples than in those of healthy controls. Network of cytokines differs in patients with recurrent furunculosis from healthy subjects. Retinol stimulation affects secretion of both pro-inflammatory and anti-inflammatory cytokines. Further studies are recommended for better understanding the pathomechanism of recurrent furunculosis and potential clinical use of retinol in patients affected by recurrent furunculosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170721
[Lr] Last revision date:170721
[St] Status:Publisher
[do] DOI:10.1007/s00005-017-0483-5

  7 / 1150 MEDLINE  
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[PMID]: 28718925
[Au] Autor:Wallace IS; McKay P; Murray AG
[Ad] Address:Marine Scotland Science, Marine Laboratory, Aberdeen, UK.
[Ti] Title:A historical review of the key bacterial and viral pathogens of Scottish wild fish.
[So] Source:J Fish Dis;40(12):1741-1756, 2017 Dec.
[Is] ISSN:1365-2761
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Thousands of Scottish wild fish were screened for pathogens by Marine Scotland Science. A systematic review of published and unpublished data on six key pathogens (Renibacterium salmoninarum, Aeromonas salmonicida, IPNV, ISAV, SAV and VHSV) found in Scottish wild and farmed fish was undertaken. Despite many reported cases in farmed fish, there was a limited number of positive samples from Scottish wild fish, however, there was evidence for interactions between wild and farmed fish. A slightly elevated IPNV prevalence was reported in wild marine fish caught close to Atlantic salmon, Salmo salar L., farms that had undergone clinical IPN. Salmonid alphavirus was isolated from wild marine fish caught near Atlantic salmon farms with a SAV infection history. Isolations of VHSV were made from cleaner wrasse (Labridae) used on Scottish Atlantic salmon farms and VHSV was detected in local wild marine fish. However, these pathogens have been detected in wild marine fish caught remotely from aquaculture sites. These data suggest that despite the large number of samples taken, there is limited evidence for clinical disease in wild fish due to these pathogens (although BKD and furunculosis historically occurred) and they are likely to have had a minimal impact on Scottish wild fish.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1707
[Cu] Class update date: 171108
[Lr] Last revision date:171108
[St] Status:In-Process
[do] DOI:10.1111/jfd.12654

  8 / 1150 MEDLINE  
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[PMID]: 28703675
[Au] Autor:Tan RM; Ploog CL
[Ti] Title:Pathology in Practice. Trichofolliculoma (ruptured) and secondary pyogranulomatous furunculosis in a rock hyrax.
[So] Source:J Am Vet Med Assoc;251(3):299-301, 2017 08 01.
[Is] ISSN:1943-569X
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 171002
[Lr] Last revision date:171002
[St] Status:In-Process
[do] DOI:10.2460/javma.251.3.299

  9 / 1150 MEDLINE  
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[PMID]: 28622574
[Au] Autor:Veenstra KA; Wang T; Alnabulsi A; Douglas A; Russell KS; Tubbs L; Arous JB; Secombes CJ
[Ad] Address:Scottish Fish Immunology Research Centre, Institute of Biological and Environmental Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen, AB24 2TZ, UK. Electronic address: k.veenstra@abdn.ac.uk.
[Ti] Title:Analysis of adipose tissue immune gene expression after vaccination of rainbow trout with adjuvanted bacterins reveals an association with side effects.
[So] Source:Mol Immunol;88:89-98, 2017 Aug.
[Is] ISSN:1872-9142
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Most existing fish vaccines are presented in the form of oil-based emulsions delivered by intraperitoneal injection. Whilst very effective they are frequently associated with inflammatory responses that can result in clinically significant side-effects often involving the adipose tissue that is in direct contact with the vaccine. To explore the potential of immune gene expression changes in the adipose tissue of fish to be markers of vaccination efficacy or development of side-effects we have studied the response to a bacterial (Aeromonas salmonicida) vaccine administered with two different adjuvants. The first adjuvant was Montanide™ ISA 763A VG, thought to induce a mostly humoral response, and the second was Montanide™ ISA 761 VG that gives a more balanced humoral and cell mediated response. Following vaccination tissue samples were collected at days 3, 14 and 28 for RTqPCR analysis. Fifty immune genes were studied with a focus on a) pro-inflammatory associated molecules and b) adaptive immune response related molecules linked with possible Th1, Th2, Th17 and T-regulatory pathways, with the expression data analysed for associations with Speilberg post-vaccination side effect scores. The results showed that the adipose tissue is a particularly sensitive and discriminatory tissue for studying adjuvant effects. A clear upregulation of many immune genes occurred in response to both vaccine groups, which persisted over time and overlapped with the appearance of visible adhesions. Our analysis revealed a relationship between adipose tissue immune function and the development of vaccine-induced adhesions giving the potential to use immune gene expression profiling in this tissue to predict the side-effects seen.
[Mh] MeSH terms primary: Adipose Tissue/immunology
Adjuvants, Immunologic/pharmacology
Oncorhynchus mykiss/immunology
Vaccination/adverse effects
[Mh] MeSH terms secundary: Aeromonas salmonicida/immunology
Animals
Bacterial Vaccines/immunology
Fish Diseases/immunology
Fish Diseases/microbiology
Fish Diseases/prevention & control
Furunculosis/immunology
Furunculosis/microbiology
Furunculosis/prevention & control
Inflammation/immunology
Mannitol/analogs & derivatives
Mannitol/pharmacology
Oleic Acids/immunology
Oleic Acids/pharmacology
T-Lymphocytes, Regulatory/immunology
Th1 Cells/immunology
Th17 Cells/immunology
Th2 Cells/immunology
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Adjuvants, Immunologic); 0 (Bacterial Vaccines); 0 (Oleic Acids); 3OWL53L36A (Mannitol)
[Em] Entry month:1710
[Cu] Class update date: 171009
[Lr] Last revision date:171009
[Js] Journal subset:IM
[Da] Date of entry for processing:170617
[St] Status:MEDLINE

  10 / 1150 MEDLINE  
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[PMID]: 28548689
[Au] Autor:Valderrama K; Saravia M; Santander J
[Ad] Address:Marine Microbial Pathogenesis and Vaccinology Laboratory, Department of Ocean Sciences, Memorial University of Newfoundland, St. John's, NL, Canada.
[Ti] Title:Phenotype of Aeromonas salmonicida sp. salmonicida cyclic adenosine 3',5'-monophosphate receptor protein (Crp) mutants and its virulence in rainbow trout (Oncorhynchus mykiss).
[So] Source:J Fish Dis;40(12):1849-1856, 2017 Dec.
[Is] ISSN:1365-2761
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Precise deletion of genes related to virulence can be used as a strategy to produce attenuated bacterial vaccines. Here, we study the deletion of the cyclic-3',5'-adenosine monophosphate (cAMP) receptor protein (Crp) in Aeromonas salmonicida, the aetiologic agent of furunculosis in marine and freshwater fish. The Crp protein is a conserved global regulator, controlling physiology processes, like sugar utilization. Deletion of the crp gene has been utilized in live attenuated vaccines for mammals, birds and warm water fish. Here, we characterized the crp gene and reported the effect of a crp deletion in A. salmonicida virulent and non-virulent isolates. We found that A. salmonicida Δcrp was not able to utilize maltose and other sugars, and its generation time was similar to the wild type. A. salmonicida ∆crp showed a higher ability of cell invasion compared to the wild type. Fish challenges showed that A. salmonicida ∆crp is ~6 times attenuated in Oncorhynchus mykiss and conferred protective immunity against the intraperitoneal challenge with A. salmonicida wild type. We concluded that deletion of A. salmonicida crp influences sugar utilization, cell invasion and virulence. Deletion of crp in A. salmonicida could be considered as part of an effective strategy to develop immersion live attenuated vaccines against furunculosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1705
[Cu] Class update date: 171108
[Lr] Last revision date:171108
[St] Status:In-Process
[do] DOI:10.1111/jfd.12658


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