Database : MEDLINE
Search on : Gastric and Antral and Vascular and Ectasia [Words]
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[PMID]: 29450749
[Au] Autor:Thomas A; Koch D; Marsteller W; Lewin D; Reuben A
[Ad] Address:MedStar Georgetown Transplant Institute, MedStar Georgetown University Hospital, Washington, DC, 20007, USA.
[Ti] Title:An Analysis of the Clinical, Laboratory, and Histological Features of Striped, Punctate, and Nodular Gastric Antral Vascular Ectasia.
[So] Source:Dig Dis Sci;, 2018 Feb 15.
[Is] ISSN:1573-2568
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Gastric antral vascular ectasia (GAVE) commonly presents as linear striped ("watermelon stomach") or punctate phenotypes, to which a newly discovered nodular form was recently added. AIMS: We performed a retrospective cohort study to detail and compare the clinical and histological characteristics of major GAVE phenotypes. METHODS: In 136 GAVE patients (tertiary care ambulatory and inpatient, median age 61.3 years, 73 men, and 63 women), clinical and laboratory results were recorded, with comorbidities, endoscopy indications, and complications of cirrhosis. In 74 patients, GAVE histopathology was cataloged by a pathologist masked to endoscopy results. RESULTS: Median age 61.3 years, 73 men, and 63 women. GAVE phenotypes were: linear striped-62 (46%), punctate-32 (24%), and nodular-41 (30%). Endoscopy was commonly performed for variceal screening in linear striped (45%) and nodular (34%) GAVE and for gastrointestinal bleeding in punctate (41%) and nodular (29%) GAVE, respectively. Of 89 cirrhotic patients, 37.5% each had linear striped or nodular GAVE, 24.7% had punctate forms (p = 0.03). Child-Turcotte-Pugh and Model for End-Stage Liver Disease scores were similar among phenotypes. Histologically, reactive epithelial hyperplasia and vascular ectasia were universal; smooth muscle proliferation was more common and consistent (78-86%) than microvascular thrombi (27-59%) and fibrohyalinosis (18-53%), which each varied with phenotype. CONCLUSIONS: Nodular GAVE is a gastric mucosal abnormality that is similar to the linear striped and punctate phenotypes, yet has distinct clinical and histological features. Increased awareness of nodular GAVE by endoscopists is needed to avoid its misdiagnosis as nonspecific antral nodules.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[St] Status:Publisher
[do] DOI:10.1007/s10620-018-4965-z

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[PMID]: 29081376
[Au] Autor:McCarty TR; Rustagi T
[Ad] Address:Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
[Ti] Title:New Indications for Endoscopic Radiofrequency Ablation.
[So] Source:Clin Gastroenterol Hepatol;, 2017 Oct 25.
[Is] ISSN:1542-7714
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Radiofrequency ablation (RFA) is a well-established treatment for several benign, pre-malignant, and malignant disorders. Although the role of RFA has been clearly defined, new indications for luminal and extra-luminal applications of endoscopic RFA-directed therapies have emerged. RFA has recently produced promising results in patients with a variety of gastrointestinal and hepatopancreatobiliary pathologies. For example, endoscopic RFA has been used to treat patients with gastric antral vascular ectasia, chronic radiation proctitis, malignant biliary strictures, and ampullary adenomas with intraductal extension. Furthermore, endoscopic ultrasound-guided RFA appears to be an effective, minimally invasive treatment for ablation of solid and cystic lesions-particularly in the pancreas. We review the newer indications for RFA and discuss potential limitations of endoscopic RFA.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171030
[Lr] Last revision date:171030
[St] Status:Publisher

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[PMID]: 29073974
[Au] Autor:Shoreibah M; Peter S
[Ad] Address:Gastroenterology and Hepatology, The University of Alabama at Birmingham.
[Ti] Title:Gastric Antral Vascular Ectasia and Metabolic Syndrome: Is There a Case for an Association?
[So] Source:Am J Med;130(11):e511, 2017 Nov.
[Is] ISSN:1555-7162
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1710
[Cu] Class update date: 171027
[Lr] Last revision date:171027
[St] Status:In-Data-Review

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[PMID]: 28983161
[Au] Autor:Mahajan P; Chandail VS
[Ad] Address:Department of Medicine, Government Medical College, Jammu, Jammu and Kashmir, India.
[Ti] Title:Etiological and Endoscopic Profile of Middle Aged and Elderly Patients with Upper Gastrointestinal Bleeding in a Tertiary Care Hospital in North India: A Retrospective Analysis.
[So] Source:J Midlife Health;8(3):137-141, 2017 Jul-Sep.
[Is] ISSN:0976-7800
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:BACKGROUND: Upper gastrointestinal (GI) bleeding is a common medical emergency associated with significant morbidity and mortality. The clinical presentation depends on the amount and location of hemorrhage and the endoscopic profile varies according to different etiology. At present, there are limited epidemiological data on upper GI bleed and associated mortality from India, especially in the middle and elderly age group, which has a higher incidence and mortality from this disease. AIM: This study aims to study the clinical and endoscopic profile of middle aged and elderly patients suffering from upper GI bleed to know the etiology of the disease and outcome of the intervention. MATERIALS AND METHODS: Out of a total of 1790 patients who presented to the hospital from May 2015 to August 2017 with upper GI bleed, and underwent upper GI endoscopy, data of 1270 patients, aged 40 years and above, was compiled and analyzed retrospectively. RESULTS: All the patients included in the study were above 40 years of age. Majority of the patients were males, with a male to female ratio of 1.6:1. The most common causes of upper GI bleed in these patients were portal hypertension-related (esophageal, gastric and duodenal varices, portal hypertensive gastropathy, and gastric antral vascular ectasia GAVE), seen in 53.62% of patients, followed by peptic ulcer disease (gastric and duodenal ulcers) seen in 17.56% of patients. Gastric erosions/gastritis accounted for 15.20%, and duodenal erosions were seen in 5.8% of upper GI bleeds. The in-hospital mortality rate in our study population was 5.83%. CONCLUSION: The present study reported portal hypertension as the most common cause of upper GI bleeding, while the most common endoscopic lesions reported were esophageal varices, followed by gastric erosion/gastritis, and duodenal ulcer.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171008
[Lr] Last revision date:171008
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/jmh.JMH_86_17

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[PMID]: 28835751
[Au] Autor:Maida M; Camilleri S; Manganaro M; Garufi S; Scarpulla G
[Ad] Address:Section of Gastroenterology, S. Elia-M. Raimondi Hospital, Caltanissetta, Italy.
[Ti] Title:Radiofrequency Ablation for Treatment of Refractory Gastric Antral Vascular Ectasia: A Systematic Review of the Literature.
[So] Source:Gastroenterol Res Pract;2017:5609647, 2017.
[Is] ISSN:1687-6121
[Cp] Country of publication:Egypt
[La] Language:eng
[Ab] Abstract:BACKGROUND AND STUDY AIMS: GAVE is an uncommon cause of upper nonvariceal bleeding and often manifests itself as occult bleeding with chronic anemia. To date, the standard of care for GAVE is endoscopic treatment with thermoablative techniques. Despite good technical results, approximately two thirds of patients remain dependent on transfusions after the therapy. One of the emerging and more promising endoscopic treatments for GAVE is radiofrequency ablation (RFA). The aim of this study is to perform a systematic review of literature in order to assess current evidence supporting the effectiveness of this technique for treatment of refractory GAVE. MATERIALS AND METHODS: Through electronic search, we identified 14 records, and after removal of duplicates and irrelevant studies, we selected 10 studies on radiofrequency ablation of GAVE: 4 prospective open-label single-center studies, 1 retrospective multicentric study, and 5 case reports. RESULTS: Among all 72 treated patients reported in literature, 74.3% achieved a clinical response, while nonfatal AEs have been reported in 4.2% of cases. CONCLUSIONS: Despite some qualitative limitations, all literature data support effectiveness of RFA for treatment of refractory GAVE. In the future, large prospective controlled trials with adequate follow-up are needed to better assess the effectiveness and safety of this procedure.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1708
[Cu] Class update date: 170828
[Lr] Last revision date:170828
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1155/2017/5609647

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[PMID]: 28803743
[Au] Autor:Hudson C; Fontenot E; Landreneau S
[Ad] Address:Department of Medicine, Louisiana State University School of Medicine, New Orleans, Louisiana, USA.
[Ti] Title:Gastric antral vascular ectasia presenting as a polypoid mass in a patient with cirrhosis.
[So] Source:Gastrointest Endosc;, 2017 Aug 10.
[Is] ISSN:1097-6779
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170929
[Lr] Last revision date:170929
[St] Status:Publisher

  7 / 439 MEDLINE  
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[PMID]: 28730919
[Au] Autor:Matsushita T; Takehara K
[Ad] Address:a Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences , Kanazawa University , Kanazawa , Japan.
[Ti] Title:An update on biomarker discovery and use in systemic sclerosis.
[So] Source:Expert Rev Mol Diagn;17(9):823-833, 2017 Sep.
[Is] ISSN:1744-8352
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Systemic sclerosis (SSc) is an autoimmune disease characterized by excessive extracellular matrix deposition in the skin and internal organs. Three major abnormalities, autoimmunity, vasculopathy, and fibrosis, are considered to play important roles in the pathophysiology of SSc. SSc is a heterogeneous disease with clinical features, disease progress, therapeutic response, and prognosis. Therefore, identification of biomarkers, which can predict the course of the disease, is required for the progress of clinical practice. Areas covered: This review focuses on various SSc biomarkers for diagnosis, disease severity, and activity, as well as newly emerging and promising SSc biomarkers. Search was through PubMed and we focus on the papers in the last 5 years. Expert commentary: Biomarkers for SSc can be categorized into several groups: activity biomarker, severity biomarker, predictive biomarker, and biomarkers for specific clinical features (skin fibrosis, lung fibrosis, pulmonary arterial hypertension, peripheral vasculopathy, gastrointestinal, and malignancy). Some chemokines, such as CCL2 and CXCL4, have been identified as biomarkers of skin and lung fibrosis in SSc. In addition, anti-RNA polymerase III antibody has been noted to be a predictive biomarker of gastric antral vascular ectasia and malignancy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170811
[Lr] Last revision date:170811
[St] Status:In-Process
[do] DOI:10.1080/14737159.2017.1356722

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[PMID]: 28726433
[Au] Autor:Kunovský L; Dastych M; Kroupa R; Hemmelova B; Muckova K; Chovancova M; Kucerova L; Dolina J
[Ti] Title:Cévní ektázie zaludecního antra a syndrom solitárního rektálního vredu - dve vzácné diagnózy jako prícina anémie u téhoz pacienta: kazuistika. Gastric antral vascular ectasia and solitary rectal ulcer syndrome - two rare diagnoses as the cause of anemia in a single patient: case report.
[So] Source:Vnitr Lek;63(5):339-342, 2017.
[Is] ISSN:0042-773X
[Cp] Country of publication:Czech Republic
[La] Language:eng
[Ab] Abstract:Gastric antral vascular ectasia (GAVE) and solitary rectal ulcer syndrome (SRUS) are both mentioned in the literature as rare causes of iron deficiency anemia and gastrointestinal (GI) bleeding. GAVE accounts for up to 4 % of upper non-variceal GI bleeding; SRUS is a rare benign disorder that presents with rectal bleeding. We present the case of a 75-year-old patient who was admitted to our facility with anemia. In the same patient, we encountered chronic bleeding from GAVE and SRUS. Both diagnoses were treated endoscopically: GAVE by argon plasma coagulation and a subsequent treatment with proton pump inhibitors and SRUS by adrenaline injection and clipping, consecutively treated with mesalazine enemas. The patient was successfully cured, resulting in a stable level of hemoglobin and no recurrent GI bleeding. We report a unique case of chronic GI bleeding caused by two uncommon diagnoses. The co-occurrence of GAVE and SRUS has not been previously described or published.Key words: anemia - endoscopy - gastric antral vascular ectasia (GAVE) - gastrointestinal bleeding - solitary rectal ulcer syndrome (SRUS).
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170720
[Lr] Last revision date:170720
[St] Status:In-Data-Review

  9 / 439 MEDLINE  
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[PMID]: 28690769
[Au] Autor:Garg S; Aslam B; Nickl N
[Ad] Address:Shashank Garg, Nicholas Nickl, Division of Digestive Diseases and Nutrition, Department of Medicine, University of Kentucky, Lexington, KY 40536, United States.
[Ti] Title:Endoscopic resolution and recurrence of gastric antral vascular ectasia after serial treatment with argon plasma coagulation.
[So] Source:World J Gastrointest Endosc;9(6):263-266, 2017 Jun 16.
[Is] ISSN:1948-5190
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:AIM: To evaluate long-term endoscopic resolution and recurrence rate of gastric antral vascular ectasia (GAVE) after argon plasma coagulation (APC) treatment. METHODS: This was an IRB-approved retrospective single center study that included patients endoscopically treated for GAVE between 1/1/2008 to 12/31/2014. The primary and secondary end points of the study were rate of endoscopic resolution of GAVE after APC treatment and recurrence rate of GAVE after endoscopic resolution, respectively. Endoscopic resolution of GAVE was defined as no endoscopic evidence of GAVE after treatment with APC. Recurrence of GAVE was defined as endoscopic reappearance of GAVE after prior resolution. RESULTS: Twenty patients met the study criteria. Median age (range) of the patients was 59.5 years (42-74 years). GAVE was associated with underlying cirrhosis in 16 (80%) patients. Indications for initial esophagogastroduodenoscopy (EGD) included hematemesis and/or melena (9/20, 45%), iron deficiency anemia (6/20, 30%), screening or surveillance of varices (4/20, 20%), and occult gastrointestinal bleeding (1/20, 5%). The patients were treated with a total of 55 APC sessions (range 1-7 sessions). Successful endoscopic resolution of GAVE was achieved in 8 out of 20 patients (40%). There was no correlation between number of treatment sessions and GAVE treatment success ( = NS). Recurrence of GAVE was noted on a subsequent EGD in 2 out of 8 patients (25%) with prior endoscopic resolution of GAVE. Median follow-up period for the study population was 627 d (range 63-1953 d). CONCLUSION: Endoscopic resolution rate of GAVE was low (40%) with a 25% recurrence rate after treatment with APC. These rates suggest that APC treatment of GAVE may not be optimal in many circumstances.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170816
[Lr] Last revision date:170816
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4253/wjge.v9.i6.263

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[PMID]: 28679138
[Au] Autor:Trindade AJ; Inamdar S; Sejpal DV
[Ad] Address:Hofstra Northwell School of Medicine, Northwell Health System, Division of Gastroenterology, Long Island Jewish Medical Center, New Hyde Park, New York, United States.
[Ti] Title:Nitrous oxide CryoBalloon therapy of refractory gastric antral vascular ectasia.
[So] Source:Endoscopy;49(9):923-924, 2017 Sep.
[Is] ISSN:1438-8812
[Cp] Country of publication:Germany
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170829
[Lr] Last revision date:170829
[St] Status:In-Data-Review
[do] DOI:10.1055/s-0043-111009


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