Database : MEDLINE
Search on : Gelsemium [Words]
References found : 142 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 15 go to page                         

  1 / 142 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 29079733
[Au] Autor:Xiong BJ; Xu Y; Jin GL; Liu M; Yang J; Yu CX
[Ad] Address:Department of Pharmacology and College of Pharmacy, Fujian Medical University, Fuzhou, 350122, Fujian, People's Republic of China.
[Ti] Title:Analgesic effects and pharmacologic mechanisms of the Gelsemium alkaloid koumine on a rat model of postoperative pain.
[So] Source:Sci Rep;7(1):14269, 2017 Oct 27.
[Is] ISSN:2045-2322
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Postoperative pain (POP) of various durations is a common complication of surgical procedures. POP is caused by nerve damage and inflammatory responses that are difficult to treat. The neuroinflammation-glia-steroid network is known to be important in POP. It has been reported that the Gelsemium alkaloid koumine possesses analgesic, anti-inflammatory and neurosteroid modulating activities. This study was undertaken to test the analgesic effects of koumine against POP and explore the underlying pharmacologic mechanisms. Our results showed that microglia and astroglia were activated in the spinal dorsal horn post-incision, along with an increase of proinflammatory cytokines (interleukin 1ß, interleukin 6, and tumor necrosis factor α). Both subcutaneous and intrathecal (i.t.) koumine treatment after incision significantly prevented mechanical allodynia and thermal hyperalgesia, inhibited microglial and astroglial activation, and suppressed expression of proinflammatory cytokines. Moreover, the analgesic effects of koumine were antagonized by i.t. administration of translocator protein (18 kDa) (TSPO) antagonist PK11195 and GABA receptor antagonist bicuculline. Together, koumine prevented mechanical allodynia and thermal hyperalgesia caused by POP. The pharmacologic mechanism of koumine-mediated analgesia might involve inhibition of spinal neuroinflammation and activation of TSPO. These data suggested that koumine might be a potential pharmacotherapy for the management of POP.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171102
[Lr] Last revision date:171102
[St] Status:In-Data-Review
[do] DOI:10.1038/s41598-017-14714-0

  2 / 142 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29035525
[Au] Autor:Liu Y; Li Y; Liu Z; Li L; Qu J; Ma S; Chen R; Dai J; Yu S
[Ad] Address:State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, China.
[Ti] Title:Sesquiterpenes from the Endophyte Glomerella cingulata.
[So] Source:J Nat Prod;80(10):2609-2614, 2017 Oct 27.
[Is] ISSN:1520-6025
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:From the cultured endophytic fungus Glomerella cingulata isolated from a toxic plant, Gelsemium elegans, one new phenanthrene (1), four new sesquiterpenes (2-5), and three known sesquiterpenes (6-8) were isolated. Their structures were elucidated using spectroscopic methods. Based on the ECD calculations, the absolute configurations of the new compounds were determined. Compounds 2, 4, and 5 inhibited lipopolysaccharide (LPS)-induced NO production in BV2 cells by 50.6, 36.1, and 29.4%, respectively, at 1 µM (positive control curcumin, IC = 4.0 µM).
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171027
[Lr] Last revision date:171027
[St] Status:In-Process
[do] DOI:10.1021/acs.jnatprod.7b00054

  3 / 142 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 28705508
[Au] Autor:Liu YC; Lin L; Cheng P; Sun ZL; Wu Y; Liu ZY
[Ad] Address:Hunan Engineering Research Center of Veterinary Drug, College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan 410128, China.
[Ti] Title:Fingerprint analysis of Gelsemium elegans by HPLC followed by the targeted identification of chemical constituents using HPLC coupled with quadrupole-time-of-flight mass spectrometry.
[So] Source:Fitoterapia;121:94-105, 2017 Sep.
[Is] ISSN:1873-6971
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Gelsemium elegans, which is a genus of the family Loganiaease, is commonly used as a traditional medicine for promoting animal growth and treating rheumatoid arthritis pain and neuropathic pain, among others. In this study, we first established a valid high-performance liquid chromatography (HPLC) method for the fingerprint analysis of Gelsemium elegans samples. Then, the comprehensive detection of chemical constituents from the samples was performed using HPLC coupled with quadrupole-time-of-flight mass spectrometry. The similarity evaluation results showed that location and area differences influenced the quality of the samples. An efficient strategy for the rapid targeted identification of chemical components was matching with a developed Gelsemium database. As a result, the accurate elemental compositions and known structures of compounds are found as hits. This process facilitated the structural identification of compounds combined with the accurate mass measurement of product ions and fragmentation behaviors. Consequently, 41 components including six alkaloids and non-alkaloids were systematically identified from Gelsemium elegans. The results showed that at least seven relatively major components existing in Gelsemium elegans may be useful for its quality control. The present analytical method combined with the developed Gelsemium database was shown to be a useful tool for investigating the chemical components of Gelsemium products.
[Mh] MeSH terms primary: Alkaloids/isolation & purification
Gelsemium/chemistry
Phytochemicals/isolation & purification
[Mh] MeSH terms secundary: Alkaloids/chemistry
Chromatography, High Pressure Liquid
Mass Spectrometry
Phytochemicals/chemistry
Plant Extracts/chemistry
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Alkaloids); 0 (Phytochemicals); 0 (Plant Extracts)
[Em] Entry month:1710
[Cu] Class update date: 171010
[Lr] Last revision date:171010
[Js] Journal subset:IM
[Da] Date of entry for processing:170714
[St] Status:MEDLINE

  4 / 142 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 28898085
[Au] Autor:Zhang W; Xu W; Wang GY; Gong XY; Li NP; Wang L; Ye WC
[Ad] Address:Institute of Traditional Chinese Medicine & Natural Products, and JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, College of Pharmacy, Jinan University , Guangzhou 510632, People's Republic of China.
[Ti] Title:Gelsekoumidines A and B: Two Pairs of Atropisomeric Bisindole Alkaloids from the Roots of Gelsemium elegans.
[So] Source:Org Lett;19(19):5194-5197, 2017 Oct 06.
[Is] ISSN:1523-7052
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Two pairs of atropisomeric bisindole alkaloids, gelsekoumidines A (1) and B (2), with a new carbon skeleton, were isolated from the roots of Gelsemium elegans. Compounds 1 and 2 represent the first examples of seco-koumine-gelsedine type alkaloids, which feature an unprecedented 20,21-seco-koumine scaffold fused with a gelsedine framework via a double bond. Their structures including absolute stereochemistry were elucidated by spectroscopic data, single-crystal X-ray diffraction, and electronic circular dichroism (ECD) calculation. A plausible biogenetic pathway for the new compounds is also proposed. Compound 2 exhibited a moderate inhibitory effect against nitric oxide (NO) production.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171007
[Lr] Last revision date:171007
[St] Status:In-Data-Review
[do] DOI:10.1021/acs.orglett.7b02463

  5 / 142 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 28596027
[Au] Autor:Wang L; Wang JF; Mao X; Jiao L; Wang XJ
[Ad] Address:Periodontal Department, Stomatology Hospital of Jilin University, Changchun 130021, China.
[Ti] Title:Gelsedine-type oxindole alkaloids from Gelsemium elegans and the evaluation of their cytotoxic activity.
[So] Source:Fitoterapia;120:131-135, 2017 Jul.
[Is] ISSN:1873-6971
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Phytochemical investigation on the 70% EtOH extract of the leaves and branches of Gelsemium elegans resulted into the isolation of five new gelsedine-type oxindole alkaloids, gelseleganins A-E (1-5). The structures of the isolated compounds were established based on 1D and 2D ( H- H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated alkaloids were tested in vitro for cytotoxic potential against seven tumor cell lines. As a result, alkaloids 3 exhibited significant cytotoxic activities against all the tested tumor cell lines with IC values <10µM.
[Mh] MeSH terms primary: Alkaloids/pharmacology
Antineoplastic Agents, Phytogenic/pharmacology
Gelsemium/chemistry
Indoles/pharmacology
Plant Leaves/chemistry
[Mh] MeSH terms secundary: Alkaloids/isolation & purification
Antineoplastic Agents, Phytogenic/isolation & purification
Cell Line, Tumor
Humans
Indoles/isolation & purification
Molecular Structure
Plant Extracts/chemistry
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Alkaloids); 0 (Antineoplastic Agents, Phytogenic); 0 (Indoles); 0 (Plant Extracts); 0 (gelsedine); 0S9338U62H (2-oxindole)
[Em] Entry month:1707
[Cu] Class update date: 170731
[Lr] Last revision date:170731
[Js] Journal subset:IM
[Da] Date of entry for processing:170609
[St] Status:MEDLINE

  6 / 142 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 28557019
[Au] Autor:Hu Y; Chen M; Wang Z; Lan Y; Tang L; Liu M; Zhao J; Hu M; Zhang L; Ye L
[Ad] Address:State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of New Drug Screening, Department of Biopharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
[Ti] Title:Development of a validated UPLC-MS/MS method for determination of humantenmine in rat plasma and its application in pharmacokinetics and bioavailability studies.
[So] Source:Biomed Chromatogr;, 2017 May 30.
[Is] ISSN:1099-0801
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Humantenmine (HMT), the most toxic compound isolated from Gelsemium elegans Benth, is a well-known active herbal compound. A rapid and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated to estimate the absolute oral bioavailability of HMT in rats. Quantification was performed by multiple reaction monitoring using electrospray ionization operated in positive ion mode with transitions of m/z 327.14 → m/z 296.19 for HMT and m/z 323.20 → m/z 236.23 for gelsemine (internal standard, IS). The linear range of the calibration curve was 1-256 nmol/L, with a lower limit of quantification at 1 nmol/L. The accuracy of HMT ranged from 89.39 to 107.5%, and the precision was within 12.24% (RSD). Excellent recovery and negligible matrix effect were observed. HMT remained stable during storage, preparation and analytical procedures. The pharmacokinetics of HMT in rats showed that HMT reached the concentration peak at 12.50 ± 2.74 min with a peak concentration of 28.49 ± 6.65 nmol/L, and the corresponding area under the concentration-time curve (AUC ) was 1142.42 ± 202.92 nmol/L min after 200 µg/kg HMT was orally administered to rats. The AUC of HMT given at 20 µg/kg by tail vein administration was 1518.46 ± 192.24 nmol/L min. The calculated absolute bioavailability of HMT was 7.66%.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1705
[Cu] Class update date: 170728
[Lr] Last revision date:170728
[St] Status:Publisher
[do] DOI:10.1002/bmc.4017

  7 / 142 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 28679292
[Au] Autor:Wang HT; Yang YC; Mao X; Wang Y; Huang R
[Ad] Address:a Department of E.N.T. , Second Hospital of Jilin University , Changchun 130041 , China.
[Ti] Title:Cytotoxic gelsedine-type indole alkaloids from Gelsemium elegans.
[So] Source:J Asian Nat Prod Res;:1-7, 2017 Jul 06.
[Is] ISSN:1477-2213
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The ethanol extract of the leaves and branches of Gelsemium elegans afforded three new gelsedine-type indole alkaloids, 11-methoxy-14,15-dihydroxyhumantenmine (1), 11-methoxy-14,15-dihydroxy-19-oxogelsenicine (2), and 11-methoxy-14-hydroxygelsedilam (3), along with one known alkaloid 11-methoxy-14-hydroxyhumantenmine (4). The structures of isolated compounds were established based on 1D and 2D ( H- H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high-resolution mass spectrometry. The isolated alkaloids were tested in vitro for cytotoxic potential against four laryngeal tumor cell lines including Hep-2, LSC-1, TR-LCC-1, and FD-LSC-1. As a result, compounds 1 and 4 exhibited some cytotoxic activities against all tested tumor cell lines with IC values of 10.9-12.1 µM and 9.2-10.8 µM, respectively.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170706
[Lr] Last revision date:170706
[St] Status:Publisher
[do] DOI:10.1080/10286020.2017.1342637

  8 / 142 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 28444801
[Au] Autor:Liu YC; Xiao S; Yang K; Ling L; Sun ZL; Liu ZY
[Ad] Address:Hunan Engineering Research Center of Veterinary Drug, College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, 410128, China.
[Ti] Title:Comprehensive identification and structural characterization of target components from Gelsemium elegans by high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry based on accurate mass databases combined with MS/MS spectra.
[So] Source:J Mass Spectrom;52(6):378-396, 2017 Jun.
[Is] ISSN:1096-9888
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:This study reports an applicable analytical strategy of comprehensive identification and structure characterization of target components from Gelsemium elegans by using high-performance liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QqTOF MS) based on the use of accurate mass databases combined with MS/MS spectra. The databases created included accurate masses and elemental compositions of 204 components from Gelsemium and their structural data. The accurate MS and MS/MS spectra were acquired through data-dependent auto MS/MS mode followed by an extraction of the potential compounds from the LC-QqTOF MS raw data of the sample. The same was matched using the databases to search for targeted components in the sample. The structures for detected components were tentatively characterized by manually interpreting the accurate MS/MS spectra for the first time. A total of 57 components have been successfully detected and structurally characterized from the crude extracts of G. elegans, but has failed to differentiate some isomers. This analytical strategy is generic and efficient, avoids isolation and purification procedures, enables a comprehensive structure characterization of target components of Gelsemium and would be widely applicable for complicated mixtures that are derived from Gelsemium preparations. Copyright © 2017 John Wiley & Sons, Ltd.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1704
[Cu] Class update date: 170621
[Lr] Last revision date:170621
[St] Status:In-Data-Review
[do] DOI:10.1002/jms.3937

  9 / 142 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 28567028
[Au] Autor:Zhou Z; Wu L; Zhong Y; Fang X; Liu Y; Chen H; Zhang W
[Ad] Address:Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
[Ti] Title: Poisoning: A Case with 8 Months of Follow-up and Review of the Literature.
[So] Source:Front Neurol;8:204, 2017.
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:BACKGROUND: ( ) is a toxic plant indigenous to Southeast Asia. It is highly poisonous due to its strong respiratory depressive effect. However, poisoning cases have not been summarized comprehensively and are rarely reported in English journals. Furthermore, none of the present reports present prognosis in detail. CASE PRESENTATION: A 26-year-old female was found comatose at home and brought to the hospital with deep coma, hypoxia, and acidosis. After mechanical ventilation for hours, the patient recovered from coma with sequelae of impaired short-term memory, disorientation, and childish behaviors. Brain magnetic resonance imaging (MRI) showed bilateral hippocampus and basal ganglia damage due to hypoxia. During 8 months of follow-up, both her symptoms and brain MRI scan improved significantly. CONCLUSION: is highly toxic. Although patients may die within 30 min due to its strong respiratory depressive effect, they can survive with timely respiratory support and enjoy gradual improvement without delayed postanoxic encephalopathy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1706
[Cu] Class update date: 170604
[Lr] Last revision date:170604
[St] Status:In-Data-Review
[do] DOI:10.3389/fneur.2017.00204

  10 / 142 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 28105568
[Au] Autor:Chen CJ; Zhong ZF; Xin ZM; Hong LH; Su YP; Yu CX
[Ad] Address:Fujian Center for Safety Evaluation of New Drug, Fujian Medical University, Fuzhou, 350004, Fujian, People's Republic of China.
[Ti] Title:Koumine exhibits anxiolytic properties without inducing adverse neurological effects on functional observation battery, open-field and Vogel conflict tests in rodents.
[So] Source:J Nat Med;71(2):397-408, 2017 Apr.
[Is] ISSN:1861-0293
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:Koumine, an active alkaloid of neurotoxic plant Gelsemium, has been focused on its therapeutic uses, especially in central nervous system. Nevertheless, less is known about the neurological effects of koumine, which hampers its potential therapeutic exploitation. Moreover, as the anxiolytic potential of Gelsemium has raised many critical issues, its active principles on the anxiolytic and other neurological effects need to be further investigated. Here, we used functional observation battery (FOB) of mice to systematically measure the neurological effects of koumine at the effective doses, and then further confirmed its anxiolytic properties in open-field test (OFT) of mice and Vogel conflict test (VCT) of rats. Koumine exhibited anxiolytic-like activities but did not affect other autonomic, neurological and physical functions in FOB. Furthermore, koumine released anxiolytic responses and anti-punishment action in a manner similar to diazepam in OFT and VCT, respectively. The results constitutes solid set of fundamental data further demonstrating anxiolytic properties of koumine at the therapeutic doses without inducing adverse neurological effects, which supports the perspectives for the development of safe and effective koumine medicine against pathological anxiety.
[Mh] MeSH terms primary: Anti-Anxiety Agents/pharmacology
Anxiety/drug therapy
Gelsemium/chemistry
Indole Alkaloids/therapeutic use
Plants/chemistry
[Mh] MeSH terms secundary: Animals
Indole Alkaloids/pharmacology
Male
Mice
Rats
Rats, Wistar
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Anxiety Agents); 0 (Indole Alkaloids); 0 (koumine)
[Em] Entry month:1704
[Cu] Class update date: 170426
[Lr] Last revision date:170426
[Js] Journal subset:IM
[Da] Date of entry for processing:170120
[St] Status:MEDLINE
[do] DOI:10.1007/s11418-017-1070-0


page 1 of 15 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information