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[PMID]: 29524720
[Au] Autor:Florian B; Lemée JM; Faguer R; Fournier HD
[Ti] Title:Lessons To be remembered from A Dural Arteriovenous Fistula Mimicking Medulla and High Cervical Cord Glioma.
[So] Source:World Neurosurg;, 2018 Mar 07.
[Is] ISSN:1878-8769
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: The radiological signs of intracranial dural arteriovenous fistulas (ICDAVFs) are heterogenous. While it is commonly accepted that hyper intense T2 Wedge MRI of the brainstem and cervical cord mainly concern gliomas, it is so far uncommon and probably unknown that ICDAVFs can imitate similar radiological pattern, especially with gadolinium contrast enhancement and cord enlargement. Thus the angiography is poorly documented in the diagnostic work-up. CASE: We report the unusual history of ICDAVFs, revealed by clinical and radiological features that mimicked a medulla or cervical spinal cord glioma. CONCLUSION: This observation provides information on the management of atypical lesions mimicking medulla or cervical cord glioma and arguments for a careful radiological study. Looking for dilated veins around the brainstem and the cord is mandatory in the workup of a supposed infiltrating brainstem or spinal cord lesion, in order to rule out an ICDAVF. Even if the hyperintense T2 images associated with contrast enhancement is in favor of a brainstem or spinal cord glioma, additional cerebral angiography should be mandatory. Moreover, this clinical case highlights the need for a multidisciplinary approach including neuroradiologist, oncologist and neurosurgeon.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  2 / 110097 MEDLINE  
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[PMID]: 29524717
[Au] Autor:Wang T; Gao T; Niu X; Xing X; Yang Y; Liu Y; Mao Q
[Ad] Address:Department of Neurosurgery, West China Hospital, Sichuan University, Guoxue Alley 37, Chengdu, 610041, China; Department of Neurosurgery, Xi'an Central Hospital, Xi'an, China.
[Ti] Title:Clinical Characteristics and Prognostic Analysis of Glioma with HIV Patients.
[So] Source:World Neurosurg;, 2018 Mar 07.
[Is] ISSN:1878-8769
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The aim of this study was to perform an survival analysis of HIV patients with glioma and to assess the relationship between various prognostic factors and overall survival. METHODS: We reported in detail the management and prognosis of two patients in our hospital and performed a quantitative and comprehensive systematic literature review of patients with HIV-associated glioma. We combined our treatment experience with retrospectively obtained treatment information and studied the resultant survival time to statistically analyze and discuss whether age, surgery, gender, WHO grade, radiotherapy, chemotherapy and RT combined CTh could predict patients' survival. RESULT: We included 34 cases in our study, including two of our cases. The median survival was 9 months. On survival analysis, among the aforementioned parameters, WHO grade(LGG/HGG), surgery(SR/SB) and radiotherapy showed significant association with overall survival by univariate analysis. Multivariable analysis showed WHO grade and surgery were a significant predictor of OS. CONCLUSION: Most patients had astrocytoma or high-grade glioma. The median survival of all of glioma in HIV patients was shorter than that of GBM patients. Surgery and WHO grade were independent prognostic factors for overall survival.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  3 / 110097 MEDLINE  
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[PMID]: 29524715
[Au] Autor:Ramakrishna R; Hsu WC; Mao J; Sedrakyan A
[Ad] Address:- Department Of Neurological Surgery, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York USA.
[Ti] Title:Surgeon Annual and Cumulative Volumes Predict Early Postoperative Outcomes After Brain Tumor Resection.
[So] Source:World Neurosurg;, 2018 Mar 07.
[Is] ISSN:1878-8769
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Surgeon volume has been previously shown to impact patient outcomes. However, data related to neuro-oncologic surgery is limited and does not include neurologic morbidities as an outcomes measure. In this study, we aimed to determine if 5-year surgeon cumulative and annual volumes predict early postoperative outcomes in patients following brain tumor surgery. METHODS: A population-based cohort of patients (n=10, 258) undergoing brain tumor resection between 2005 and 2014 were included for study utilizing the New York Statewide Planning and Research Cooperation System. Surgeons were categorized by their cumulative and annual surgical volume. RESULTS: Patients treated by high cumulative/high annual (HC/HA) volume surgeons had shorter length of stay (median 5 days vs 8 days vs 8 days vs 6 days respectively, p<0.01), lower charges (median 70,025 vs $77,043 vs $93,715 vs $77,018 respectively, p<0.01) and less non-routine discharge (41% vs 48% vs 50.9% vs 43.9% respectively, p<0.01) compared with patients treated by surgeons from the LC/LA, LC/HA, HC/LA groups. Similarly, HC/HA volume surgeons also had lower rate of hydrocephalus (9.9% vs 10.4% vs 13.7% respectively, p=0.02), medical complications (6.9% vs 11.2% vs 11.5% respectively, p<0.01), neurologic complications (44.1% vs 46.8% vs 48.1% respectively, p=0.03), 30-day reoperation (5.1% vs 6.9% vs 7.1% respectively, p<0.01) and 30-day death (3.3% vs 5.4% vs 5.2%, p<0.01) compared with LC/LA and LC/HA volume surgeons. CONCLUSION: There is some evidence for improved postoperative outcomes when surgery is performed by high cumulative and high annual volume surgeons. This suggests that subspecialization in surgical neurooncology should be considered.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  4 / 110097 MEDLINE  
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[PMID]: 29524710
[Au] Autor:Roessler K; Kasper BS; Coras R; Arinrad S; Scholz M; Hamer HH; Blümcke I; Buchfelder M
[Ad] Address:Neurosurgical Clinic. Electronic address: Karl.Roessler@uk-erlangen.de.
[Ti] Title:Technical modification of amygdalo-hippocampectomy (AHE) in temporal lobe epilepsy surgery to further reduce severe neurological complications. A clinical- anatomical study.
[So] Source:World Neurosurg;, 2018 Mar 07.
[Is] ISSN:1878-8769
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Temporal lobe resection (TLR) including amygdalo-hippocampectomy (AHE) is the most frequent performed procedure in epilepsy surgery. Due to close anatomical relationship of the mesial temporal structures and the midbrain and choroidal fissure, the risk of severe complications like postoperative stroke is up to 2.5%. METHODS: We developed a modification of the classical technique for AHE by early entering the choroidal fissure for identification of crus cerebri, posterior cerebri artery and oculomotor nerve via the anterior part of the fronto- mesial temporal horn cleft. Uncus and amygdala were removed second step after visualization of the cleavage plane between midbrain and middle cerebral artery. RESULTS: Altogether, 81 patients (47 females, 34 males, mean age 40 years at surgery) had temporal lobe epilepsy surgery including AHE for heterogeneous pathologies using this surgical modification (45 hippocampal sclerosis, 11 ganglioglioma, 2 dysembryoplastic neuroepithelioma (DNET), 2 diffuse glioma 21 other pathologies like cavernoma, scar tissue or mild cortical dysplasia). All patients had anterior temporal resection including AHE by using our modified technique. Seizure outcome was favorable after a mean follow up of 27 (from 3 to 56) months: 64% were completely seizure free (Engel Class 1A) and 75% had Engel Class 1 outcome. There was no mortality, 0% permanent severe neurological and 3.7% surgical complications. CONCLUSION: The newly described modification for AHE demonstrated low complication rates in surgery of medically refractory temporal lobe epilepsy. Its attention especially contributes to avoid permanent severe complications.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  5 / 110097 MEDLINE  
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[PMID]: 29524606
[Au] Autor:Zhuang H; Li Q; Zhang X; Ma X; Wang Z; Liu Y; Yi X; Chen R; Han F; Zhang N; Li Y
[Ad] Address:Key Laboratory of Breast Cancer Prevention and Therapy, Laboratory of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital; Research Center of Basic Medical Sciences; Department of Pathogen Biology & Department of Genetics, School of Basic Medical Sciences; Tianjin Medic
[Ti] Title:Downregulation of Glycine Decarboxylase Enhanced Cofilin-mediated Migration in Hepatocellular Carcinoma Cells.
[So] Source:Free Radic Biol Med;, 2018 Mar 07.
[Is] ISSN:1873-4596
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Metabolic reprogramming is a hallmark of cancer. Glycine decarboxylase (GLDC), an oxidoreductase, plays an important role in amino acid metabolism. While GLDC promotes tumor initiation and proliferation in non-small cell lung cancer and glioma and it was reported as a putative tumor suppressor gene in gastric cancer, the role of GLDC in hepatocellular carcinoma (HCC) is unknown. In the current study, microarray-based analysis suggested that GLDC expression was low in highly malignant HCC cell lines, and clinicopathological analysis revealed a decrease in GLDC in HCC tumor samples. While the knockdown of GLDC enhanced cancer cell migration and invasion, GLDC overexpression inhibited them. Mechanistic studies revealed that GLDC knockdown increased the levels of reactive oxygen species (ROS) and decreased the ratio of glutathione/oxidized glutathione (GSH/GSSG), which in turn dampened the ubiquitination of cofilin, a key regulator of actin polymerization. Consequently, the protein level of cofilin was elevated, which accounted for the increase in cell migration. The overexpression of GLDC reversed the phenotype. Treatment with N-acetyl-L-cysteine decreased the protein level of cofilin while treatment with H O increased it, further confirming the role of ROS in regulating cofilin degradation. In a tumor xenographic transplant nude mouse model, the knockdown of GLDC promoted intrahepatic metastasis of HCC while GLDC overexpression inhibited it. Our data indicate that GLDC downregulation decreases ROS-mediated ubiquitination of cofilin to enhance HCC progression and intrahepatic metastasis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  6 / 110097 MEDLINE  
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[PMID]: 29524580
[Au] Autor:Lin Y; Wu Z
[Ad] Address:Department of Neurosurgery, Zhejiang Tongde Hospital, Hangzhou, Zhejiang 310012, PR China.
[Ti] Title:MicroRNA-128 inhibits proliferation and invasion of glioma cells by targeting COX-2.
[So] Source:Gene;, 2018 Mar 07.
[Is] ISSN:1879-0038
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:MicroRNAs (miRNA), a class of small noncoding RNAs, regulates message RNA (mRNA) by targeting the 3'-untranslated region (3'-UTR) resulting in suppression of gene expression. In this study, we identified the expression and function of miR-128, which was found to be downregulated in glioma tissues and glioma cells by real time PCR. Overexpression of miR-128 mimics into LN229 and U251 cells could inhibit proliferation and invasion of glioma cells. However, the inhibitory effects of miR-128 mimics on the invasion and proliferation of glioma cells were reversed by overexpression of cyclooxygenase-2 (COX-2). Our data showed that COX-2 was a candidate target of miR-128. Luciferase activity of 3'-UTR of COX-2 was reduced in the presence of miR-128. Additionally, miR-128 obviously decreased COX-2 mRNA stability determined by real time PCR. Contrarily, we found that miR-128 inhibitor significantly increased the COX-2 mRNA expression, and elevated the protein expression of MMP9 and ki67, and promoted the proliferation of glioma cells. Furthermore, luciferase activity of the 3'-UTR was upregulated by miR-128 inhibitor. All of these results supported that miR-128 was a direct regulator of COX-2. Further studies proved that COX-2 was elevated in glioma tissues and its expression was negatively correlated with the levels of miR-128. These findings may establish miR-128 as a new potential target for the treatment of patients with gliomas.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  7 / 110097 MEDLINE  
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[PMID]: 29471095
[Au] Autor:Medeiros GKVV; Queiroga RCRE; Costa WKA; Gadelha CAA; E Lacerda RR; Lacerda JTJG; Pinto LS; Braganhol E; Teixeira FC; de S Barbosa PP; Campos MIF; Gonçalves GF; Pessôa HLF; Gadelha TS
[Ad] Address:Programa de Pós-Graduação em Ciências da Nutrição, Universidade Federal da Paraíba, João Pessoa, Paraíba, Brazil.
[Ti] Title:Proteomic of goat milk whey and its bacteriostatic and antitumour potential.
[So] Source:Int J Biol Macromol;113:116-123, 2018 Feb 19.
[Is] ISSN:1879-0003
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Goat whey is normally discarded in the milk processing industry. However, several studies have addressed its biological properties and possible use in human or animal diet. The present study aimed to analysis the protein profile of goat whey to evaluate its possible oxidant, antioxidant, antibacterial, antitumour, and cytotoxic activities in vitro against human erythrocytes. Goat whey was skimmed, and crude protein extract (CPE) was obtained. Next, protein fractions (F) were obtained using ammonium sulphate precipitation method. The proteins were characterized by SDS-PAGE, two-dimensional electrophoresis and soluble protein measurements. No significant differences were observed in protein profile of CPE, F 30-60% and F 60-90%. The highest protein content was found in F 60-90% (0.41mgP/mL). All samples, except F 0-30% showed bacteriostatic activity against different bacterial strains. Only CPE at a concentration of 1000µg/mL was haemolytic against human erythrocytes. Oxidant activity against erythrocytes was not observed. Antioxidant activity was observed only for CPE. Cytotoxicity against C6 rat glioma cell line that was performed with CPE revealed tumour cell death>70% at concentrations of 0.05 and 0.1µg/mL. These results demonstrate at first time that CPE may be used as an antioxidant, bacteriostatic and cytotoxic compound against tumour cells.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  8 / 110097 MEDLINE  
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[PMID]: 29424334
[Au] Autor:Kearney H; Cryan J; Beausang A; Looby S; Brett FM
[Ti] Title:Reactive gliosis mimicking tumor recurrence - a case series documenting MRI abnormalities and neuropathological correlates.
[So] Source:Clin Neuropathol;, 2018 02 09.
[Is] ISSN:0722-5091
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:The aim of this study is to identify, in our center, all cases of foreign-body reactions to hemostatic agents or other prostheses resulting in a radiological suspicion of tumor recurrence. We interrogated our internal database to identify all such cases and systematically evaluated the MRI brain scans of patients: (i) at the time of initial tumor diagnosis, (ii) postoperatively, (iii) and at the time of suspected tumor recurrence. In addition, we reviewed each patient's operative notes and reviewed the histology of all cases following a second surgical intervention. In total, we identified 8 patients, 7 of whom had a WHO grade II glioma at initial surgery. We did not identify any distinguishing radiological abnormalities from the initial diagnostic brain scan to the suspected recurrence, and histologically all cases were characterized by extensive gliosis; with both macrophages and reactive astrocytes present throughout. The cause of gliosis was identified as being relating to hemostatic agents in 4 cases; in the other 4 cases, the foreign-body reaction was presumed to be caused be materials used in a craniotomy or cranioplasty. This study highlights the difficulty in radiologically diagnosing a foreign-body reaction and also identifies that such a gliotic reaction may occur as a consequence of exogenous materials used in a craniotomy or cranioplasty.
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[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:Publisher
[do] DOI:10.5414/NP301084

  9 / 110097 MEDLINE  
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[PMID]: 29272336
[Au] Autor:Thompson J; Bi M; Murchison AG; Makuch M; Bien CG; Chu K; Farooque P; Gelfand JM; Geschwind MD; Hirsch LJ; Somerville E; Lang B; Vincent A; Leite MI; Waters P; Irani SR; Faciobrachial Dystonic Seizures Study Group
[Ad] Address:Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DS, UK.
[Ti] Title:The importance of early immunotherapy in patients with faciobrachial dystonic seizures.
[So] Source:Brain;141(2):348-356, 2018 Feb 01.
[Is] ISSN:1460-2156
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Faciobrachial dystonic seizures and limbic encephalitis closely associate with antibodies to leucine-rich glioma-inactivated 1 (LGI1). Here, we describe 103 consecutive patients with faciobrachial dystonic seizures and LGI1 antibodies to understand clinical, therapeutic and serological differences between those with and without cognitive impairment, and to determine whether cessation of faciobrachial dystonic seizures can prevent cognitive impairment. The 22/103 patients without cognitive impairment typically had normal brain MRI, EEGs and serum sodium levels (P < 0.0001). Overall, cessation of faciobrachial dystonic seizures with antiepileptic drugs alone occurred in only 9/89 (10%) patients. By contrast, 51% showed cessation of faciobrachial dystonic seizures 30 days after addition of immunotherapy (P < 0.0001), with earlier cessation in cognitively normal patients (P = 0.038). Indeed, expedited immunotherapy (P = 0.031) and normal cognition (P = 0.0014) also predicted reduced disability at 24 months. Furthermore, of 80 patients with faciobrachial dystonic seizures as their initial feature, 56% developed cognitive impairment after 90 days of active faciobrachial dystonic seizures. Whereas only one patient developed cognitive impairment after cessation of faciobrachial dystonic seizures (P < 0.0001). All patients had IgG4-LGI1 antibodies, but those with cognitive impairment had higher proportions of complement-fixing IgG1 antibodies (P = 0.03). Both subclasses caused LGI1-ADAM22 complex internalization, a potential non-inflammatory epileptogenic mechanism. In summary, faciobrachial dystonic seizures show striking time-sensitive responses to immunotherapy, and their cessation can prevent the development of cognitive impairment.awx323media15681705685001.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Data-Review
[do] DOI:10.1093/brain/awx323

  10 / 110097 MEDLINE  
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[PMID]: 29524243
[Au] Autor:Elmghirbi R; Nagaraja TN; Brown SL; Keenan KA; Panda S; Cabral G; Bagher-Ebadian H; Divine GW; Lee IY; Ewing JR
[Ad] Address:Department of Physics, Oakland University, Rochester, Michigan.
[Ti] Title:Toward a noninvasive estimate of interstitial fluid pressure by dynamic contrast-enhanced MRI in a rat model of cerebral tumor.
[So] Source:Magn Reson Med;, 2018 Mar 09.
[Is] ISSN:1522-2594
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: This study demonstrates a DCE-MRI estimate of tumor interstitial fluid pressure (TIFP) and hydraulic conductivity in a rat model of glioblastoma, with validation against an invasive wick-in-needle (WIN) technique. An elevated TIFP is considered a mark of aggressiveness, and a decreased TIFP a predictor of response to therapy. METHODS: The DCE-MRI studies were conducted in 36 athymic rats (controls and posttreatment animals) with implanted U251 cerebral tumors, and with TIFP measured using a WIN method. Using a model selection paradigm and a novel application of Patlak and Logan plots to DCE-MRI data, the MRI parameters required for estimating TIFP noninvasively were estimated. Two models, a fluid-mechanical model and a multivariate empirical model, were used for estimating TIFP, as verified against WIN-TIFP. RESULTS: Using DCE-MRI, the mean estimated hydraulic conductivity (MRI-K) in U251 tumors was (2.3 ± 3.1) × 10 (mm /mmHg-s) in control studies. Significant positive correlations were found between WIN-TIFP and MRI-TIFP in both mechanical and empirical models. For instance, in the control group of the fluid-mechanical model, MRI-TIFP was a strong predictor of WIN-TIFP (R = 0.76, p < .0001). A similar result was found in the bevacizumab-treated group of the empirical model (R = 0.93, p = .014). CONCLUSION: This research suggests that MRI dynamic studies contain enough information to noninvasively estimate TIFP in this, and possibly other, tumor models, and thus might be used to assess tumor aggressiveness and response to therapy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1002/mrm.27163


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