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[PMID]: 28247977
[Au] Autor:Liu YF; Kim Y; Yoo T; Han P; Inman JC
[Ad] Address:Department of Otolaryngology - Head and Neck Surgery, Loma Linda University Medical Center, Loma Linda, CA, USA.
[Ti] Title:Burning mouth syndrome: a systematic review of treatments.
[So] Source:Oral Dis;, 2017 Mar 01.
[Is] ISSN:1601-0825
[Cp] Country of publication:Denmark
[La] Language:eng
[Ab] Abstract:Burning mouth syndrome (BMS) is a chronic oral pain syndrome that primarily affects peri- and postmenopausal women. It is characterized by oral mucosal burning and may be associated with dysgeusia, paresthesia, dysesthesia, and xerostomia. The etiology of the disease process is unknown, but is thought to be neuropathic in origin. The goal of this systematic review was to assess the efficacy of the various treatments for BMS. Literature searches were conducted through PubMed, Web of Science, and Cochrane Library databases, which identified 22 randomized controlled trials. Eight studies examined alpha-lipoic acid (ALA), three clonazepam, three psychotherapy, and two capsaicin, which all showed modest evidence of potentially decreasing pain/burning. Gabapentin was seen in one study to work alone and synergistically with ALA. Other treatments included vitamins, benzydamine hydrochloride, bupivacaine, Catuama, olive oil, trazodone, urea, and Hypericum perforatum. Of these other treatments, Catuama and bupivacaine were the only ones with significant positive results in symptom improvement. ALA, topical clonazepam, gabapentin, and psychotherapy may provide modest relief of pain in BMS. Gabapentin may also boost the effect of ALA. Capsaicin is limited by its side effects. Catuama showed potential for benefit. Future studies with standardized methodology and outcomes containing more patients are needed.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1703
[Cu] Class update date: 170403
[Lr] Last revision date:170403
[St] Status:Publisher
[do] DOI:10.1111/odi.12660

  2 / 260 MEDLINE  
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[PMID]: 28437054
[Au] Autor:Rathore S; Svirsky J; Desai B
[Ti] Title:Tonsillar Squamous Cell Carcinoma: An Additional Consideration for Atypical Glossodynia.
[So] Source:Dent Today;35(7):140-1, 2016 Jul.
[Is] ISSN:8750-2186
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Carcinoma, Squamous Cell/complications
Glossalgia/etiology
Tonsillar Neoplasms/complications
[Mh] MeSH terms secundary: Female
Humans
Middle Aged
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170803
[Lr] Last revision date:170803
[Js] Journal subset:D
[Da] Date of entry for processing:170425
[St] Status:MEDLINE

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[PMID]: 27207008
[Au] Autor:Vellappally S
[Ad] Address:Assistant Professor, Dental Health Department, Dental Biomaterials Research Chair, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia, Phone: +966537274240, e-mail: drsajithvn@gmail.com.
[Ti] Title:Burning Mouth Syndrome: A Review of the Etiopathologic Factors and Management.
[So] Source:J Contemp Dent Pract;17(2):171-6, 2016 Feb 01.
[Is] ISSN:1526-3711
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Burning mouth syndrome (BMS) is characterized by pain in the mouth with or with no inflammatory signs and no specific lesions. Synonyms found in literature include glossodynia, oral dysesthesia, glossopyrosis, glossalgia, stomatopyrosis, and stomatodynia. Burning mouth syndrome generally presents as a triad: Mouth pain, alteration in taste, and altered salivation, in the absence of visible mucosal lesions in the mouth. The syndrome generally manifests spontaneously, and the discomfort is typically of a continuous nature but increases in intensity during evening and at night. The etiopathogenesis seems to be complex and in a large number of patients probably involves interactions among local, systemic, and/or psychogenic factors. The differential diagnosis requires the exclusion of oral mucosal lesions or blood test alterations that can produce burning mouth sensation. Management is always based on the etiological agents involved. If burning persists after local or systemic conditions are treated, then treatment is aimed at controlling neuropathic symptoms. Treatment of BMS is still unsatisfactory, and there is no definitive cure. As a result, a multidisciplinary approach is required to bring the condition under better control. The aim of this review was to discuss several aspects of BMS, update current knowledge, and provide guidelines for patient management.
[Mh] MeSH terms primary: Burning Mouth Syndrome
[Mh] MeSH terms secundary: Burning Mouth Syndrome/drug therapy
Burning Mouth Syndrome/etiology
Burning Mouth Syndrome/therapy
Cognitive Therapy
Humans
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1710
[Cu] Class update date: 171030
[Lr] Last revision date:171030
[Js] Journal subset:D; IM
[Da] Date of entry for processing:160522
[St] Status:MEDLINE

  4 / 260 MEDLINE  
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[PMID]: 27163925
[Au] Autor:Connolly D; Pavlis M; Moghaddam S
[Ad] Address:Department of Dermatology and Cutaneous Biology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
[Ti] Title:Painful lesions on the tongue.
[So] Source:Cutis;97(4):E4-5, 2016 Apr.
[Is] ISSN:2326-6929
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Herpes Simplex/diagnosis
Tongue Diseases/diagnosis
[Mh] MeSH terms secundary: Aged
Diagnosis, Differential
Glossalgia/etiology
Herpes Simplex/complications
Herpes Simplex/pathology
Humans
Male
Tongue Diseases/complications
Tongue Diseases/pathology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1704
[Cu] Class update date: 170410
[Lr] Last revision date:170410
[Js] Journal subset:IM
[Da] Date of entry for processing:160511
[St] Status:MEDLINE

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[PMID]: 28509498
[Au] Autor:Libih DA; Iordanishvili AK; Ryzhak GA
[Ad] Address:Saint-Petersburg Institute of Bioregulation and Gerontology, Saint-Petersburg, 197110, Russian Federation; vladimirpiter@mail.ru.
[Ti] Title:[Prevalence of stomalgy and its causes in people of different age].
[So] Source:Adv Gerontol;28(3):567-570, 2015.
[Is] ISSN:1561-9125
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:On the basis of analysis of primary medical records of 9 158 (3 329 males and 5 829 females) patients of average, elderly and old age of outpatient clinics the prevalence of pain and paresthesys of the oral mucosa and tongue was studied. Profile of outpatient medical institutions, where people suffering from painful phenomena and paresthesys of the oral mucosa pass examination and treatment was defined. The causal factors that play a role in the origin and development of this disease in patients of older age groups were established.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1705
[Cu] Class update date: 170516
[Lr] Last revision date:170516
[St] Status:PubMed-not-MEDLINE

  6 / 260 MEDLINE  
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[PMID]: 26817112
[Au] Autor:Ostrovskaya LY; Bulkina NV; Osipova UL
[Ti] Title:[GLOSSALGIA SYNDROME AS SUPRAESOPHAGEAL MANIFESTATION OF GASTROESOPHAGEAL REFLUX DISEASE].
[So] Source:Eksp Klin Gastroenterol;(6):95-8, 2015.
[Is] ISSN:1682-8658
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:The case of clinical supervision of the patient having polimorbid pathology is presented. One of extraesophageal manifestations of a gastroesophageal reflux disease is the glossalgia. Glossalgia is the polyetiological disease. Treatment needs to be carried out taking into account the factors causing emergence of a glossalgia. In this regard normalization of functions of organs and systems of an organism is provided.
[Mh] MeSH terms primary: Esophagus/pathology
Gastroesophageal Reflux
Glossalgia
[Mh] MeSH terms secundary: Aged
Gastroesophageal Reflux/complications
Gastroesophageal Reflux/pathology
Gastroesophageal Reflux/therapy
Glossalgia/etiology
Glossalgia/pathology
Glossalgia/therapy
Humans
Male
Syndrome
[Pt] Publication type:CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1602
[Cu] Class update date: 160127
[Lr] Last revision date:160127
[Js] Journal subset:IM
[Da] Date of entry for processing:160129
[St] Status:MEDLINE

  7 / 260 MEDLINE  
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[PMID]: 26597294
[Au] Autor:Tooyama H; Matsumoto T; Hayashi K; Kurashina K; Kurita H; Uchida M; Kasuga E; Honda T
[Ad] Address:Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, Shinshu University Hospital, 3-1-1 Asahi, Matsumoto, 390-8621, Japan. shu5mai@yahoo.co.jp.
[Ti] Title:Candida concentrations determined following concentrated oral rinse culture reflect clinical oral signs.
[So] Source:BMC Oral Health;15:150, 2015 Nov 24.
[Is] ISSN:1472-6831
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Oral candidiasis is an infection caused by a yeast-like fungus called Candida. Various methods can be used to isolate Candida from the oral cavity. However, it is difficult to correctly and satisfactorily diagnose oral candidiasis because currently no microbiological or laboratory standards based on samples from the oral cavity are available. The aim of this study is to establish a reliable laboratory test for diagnosing oral candidiasis. METHODS: Oral swab, rinse and concentrated rinse samples were obtained from 200 consecutive outpatients (103 male patients and 97 female patients; mean age, 47.2 years; age range, 9-89 years). Candida colonies from cultured samples were enumerated to compare the sensitivities and specificities of the above sampling methods, and the associations between Candida detection or concentration and the clinical oral signs were examined. RESULTS: The mean colony numbers were 263 ± 590 CFU/swab for the swab method, 2894 ± 6705 CFU/100 µL for the rinse method, and 9245 ± 19,030 CFU/100 µL for the concentrated rinse method. The median numbers were 23 CFU/swab for the swab method, 56 CFU/100 µL for the rinse method, and 485 CFU/100 µL for the concentrated rinse method. Candida was detected in the oral cavity of 33.5 % and 52.0 % of the outpatients by the swab method and concentrated rinse, respectively. Candida concentrations determined by the concentrated rinse were closely related to the severity of the clinical oral signs. The positive predictive values of residual root, redness of the oral mucosa, denture, glossalgia, dry mouth, and taste disorder were useful predictors of oral candidiasis. CONCLUSIONS: Concentrated rinse sampling is suitable for evaluating oral candidiasis, and Candida concentrations examined using this method strongly associated with the oral signs associated with Candida infection.
[Mh] MeSH terms primary: Candida/isolation & purification
Candidiasis, Oral/diagnosis
Mouthwashes
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Aged, 80 and over
Child
Colony Count, Microbial
Female
Humans
Male
Middle Aged
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Mouthwashes)
[Em] Entry month:1709
[Cu] Class update date: 170913
[Lr] Last revision date:170913
[Js] Journal subset:D; IM
[Da] Date of entry for processing:151125
[St] Status:MEDLINE
[do] DOI:10.1186/s12903-015-0138-z

  8 / 260 MEDLINE  
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[PMID]: 26379550
[Au] Autor:Yamaguchi K
[Ad] Address:Oral and Maxillofacial Surgery, Kagoshima University Hospital Kagoshima, Japan.
[Ti] Title:Traditional Japanese herbal medicines for treatment of odontopathy.
[So] Source:Front Pharmacol;6:176, 2015.
[Is] ISSN:1663-9812
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:This article highlights several refractory oral diseases, such as stomatitis, burning mouth syndrome (BMS), glossalgia, atypical facial pain (AFP), oral cancer, dry mouth, and Sjögren's syndrome (SJS), in which use of Japanese herbal medicines, Kampo medicines (KM), on the basis of Kampo theory could exert the maximum effects on human body. (1) In acute stomatitis, heat because of agitated vital energy may affect the head, chest, and middle abdominal region. Stomatitis is also related to the generation of reactive oxygen species (ROS). There are many antioxidants in the crude extracts of KM. Thus, we can control environmental factors (cold, heat, dampness, dryness) and vital energy, blood, and fluid of the organ systemically using KM to treat stomatitis and eliminate local ROS accumulation. (2) BMS, glossalgia, and AFP are multifactorial syndromes involving the interaction of biological and psychological factors. Local temperature decrease and edema often occur in chronic pain. These are local circulatory disturbances that can be resolved by improving the flow of blood and fluid. Several KM, such as Tokishakuyakusan and Kamishoyosan (KSS), are effective for enhancing peripheral circulation. Those such as Saikokaryukotuboreito, Yokukansan, KSS, and Saibokutou can reduce stress and associated pain by altering glutamatergic and monoaminergic transmission in the brain. The clinical efficacy of KM for BMS and AFP may depend on the regulation of the mesolimbic dopaminergic and descending glutamatergic pain modulation systems. (3) Regarding oral cancer treatment, I introduce four possible applications of KM, inhibition of the proliferation of cancer cells, complementation of the main cancer therapy, reduction of side effect caused by the main anti-cancer therapy and improvement of quality of life such as the overall status and/or oral discomfort. This review explains in more details Hozai such as Hochuekkito (HET), Juzendaihoto, and Ninjinyoeito (NYT) that are frequently used to improve both immunosuppression and deficiencies of Ki, Ketsu, and Sui in oral cancer patients. (4) Heat- and cold-dryness stages exist in dry mouth and SJS. Byakkokaninjinto is useful for heat-dryness, while NYT, Bakumondoto, and HET have moisturizing effects in the cold-dryness stage. Thus, Kampo therapy is useful for many oral diseases that cannot be cured by western medicine.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1509
[Cu] Class update date: 170220
[Lr] Last revision date:170220
[Da] Date of entry for processing:150918
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.3389/fphar.2015.00176

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[PMID]: 26270588
[Au] Autor:Shinoda M; Takeda M; Honda K; Maruno M; Katagiri A; Satoh-Kuriwada S; Shoji N; Tsuchiya M; Iwata K
[Ad] Address:aDepartment of Physiology, Nihon University School of Dentistry, Tokyo, Japan bLaboratory of Food and Physiological Sciences, Department of Food and Life Sciences, School of Life and Environmental Sciences, Azabu University, Sagamihara, Japan cDepartment of Complete Denture Prosthodontics, Nihon University School of Dentistry, Tokyo, Japan dDivision of Oral Diagnosis, Tohoku University Graduate School of Dentistry, Sendai, Japan eTohoku Fukushi University, Sendai, Japan.
[Ti] Title:Involvement of peripheral artemin signaling in tongue pain: possible mechanism in burning mouth syndrome.
[So] Source:Pain;156(12):2528-37, 2015 Dec.
[Is] ISSN:1872-6623
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Burning mouth syndrome is characterized by altered sensory qualities, namely tongue pain hypersensitivity. We found that the mRNA expression of Artemin (Artn) in the tongue mucosa of patients with burning mouth syndrome was significantly higher than that of control subjects, and we developed a mouse model of burning mouth syndrome by application of 2,4,6-trinitrobenzene sulfonic acid (TNBS) diluted with 50% ethanol to the dorsum of the tongue. TNBS treatment to the tongue induced persistent, week-long, noninflammatory tongue pain and a significant increase in Artn expression in the tongue mucosa and marked tongue heat hyperalgesia. Following TNBS treatment, the successive administration of the transient receptor potential vanilloid 1 (TRPV1) antagonist SB366791 or neutralizing anti-Artn antibody completely inhibited the heat hyperalgesia. The number of glial cell line-derived neurotrophic factor family receptor α3 (GFRα3)-positive and TRPV1-positive trigeminal ganglion (TG) neurons innervating the tongue significantly increased following TNBS treatment and was significantly reduced by successive administration of neutralizing anti-Artn antibody. The capsaicin-induced current in TG neurons innervating the tongue was enhanced following TNBS treatment and was inhibited by local administration of neutralizing anti-Artn antibody to the tongue. These results suggest that the overexpression of Artn in the TNBS-treated tongue increases the membrane excitability of TG neurons innervating the tongue by increasing TRPV1 sensitivity, which causes heat hyperalgesia. This model may be useful for the study of tongue pain hypersensitivity associated with burning mouth syndrome.
[Mh] MeSH terms primary: Burning Mouth Syndrome/genetics
Glossalgia/metabolism
Hyperalgesia/metabolism
Nerve Tissue Proteins/genetics
Nerve Tissue Proteins/metabolism
Neurons/metabolism
RNA, Messenger/metabolism
Tongue/metabolism
Trigeminal Ganglion/metabolism
[Mh] MeSH terms secundary: Aged
Aged, 80 and over
Anilides/pharmacology
Animals
Antibodies, Neutralizing/pharmacology
Blotting, Western
Burning Mouth Syndrome/chemically induced
Burning Mouth Syndrome/metabolism
Cinnamates/pharmacology
Disease Models, Animal
Female
Glial Cell Line-Derived Neurotrophic Factor Receptors/metabolism
Glossalgia/chemically induced
Hot Temperature
Humans
Hyperalgesia/chemically induced
Male
Mice
Middle Aged
Nerve Tissue Proteins/pharmacology
Patch-Clamp Techniques
Real-Time Polymerase Chain Reaction
Signal Transduction
TRPV Cation Channels/antagonists & inhibitors
TRPV Cation Channels/metabolism
Tongue/drug effects
Trigeminal Ganglion/cytology
Trinitrobenzenesulfonic Acid/toxicity
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (ARTN protein, human); 0 (Anilides); 0 (Antibodies, Neutralizing); 0 (Artn protein, mouse); 0 (Cinnamates); 0 (Gfra3 protein, mouse); 0 (Glial Cell Line-Derived Neurotrophic Factor Receptors); 0 (N-(3-methoxyphenyl)-4-chlorocinnamanilide); 0 (Nerve Tissue Proteins); 0 (RNA, Messenger); 0 (TRPV Cation Channels); 0 (TRPV1 protein, mouse); 8T3HQG2ZC4 (Trinitrobenzenesulfonic Acid)
[Em] Entry month:1609
[Cu] Class update date: 151120
[Lr] Last revision date:151120
[Js] Journal subset:IM
[Da] Date of entry for processing:150814
[St] Status:MEDLINE
[do] DOI:10.1097/j.pain.0000000000000322

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[PMID]: 26252275
[Au] Autor:Seccia TM; Rossitto G; Calò LA; Rossi GP
[Ad] Address:From the Internal Medicine (TMS, GR, GPR) and Nephrology (LC), Department of Medicine - DIMED, University of Padua, Italy.
[Ti] Title:Oral Burning With Dysphagia and Weight Loss.
[So] Source:Medicine (Baltimore);94(31):e1163, 2015 Aug.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Fibromyalgia is a disorder characterized by an abnormal pain regulation. Widespread pain, fatigue, and sleep disturbance are the prevalent symptoms. When unusual symptoms are overbearingly predominant at clinical presentation, the diagnosis becomes challenging.We report on the case of a patient with fibromyalgia, who presented with dysphagia, odynophagia, and glossodynia as prevalent symptoms. Difficulty in swallowing gradually developed over a month prior hospitalization, and worsened progressively so that nourishment and fluid intake were impeded.Because anemia with mild iron deficiency was found, esophagogastroduodenoscopy was performed, but no lesions were seen in the upper digestive tract. Levels of zinc and vitamin B12 were normal. Intense pain at pelvis and the inferior limbs, which was at a first glance referred to as osteoarthrosis, associated with oral symptoms and feeling of being in the clouds allowed us to diagnose fibromyalgia. Amitriptyline was used, with relief of symptoms.Although oropharyngeal symptoms were occasionally reported in fibromyalgia, they are often overlooked. The present case, therefore, testifies the need to consider the diagnosis of fibromyalgia when the patient presents with such symptoms that cannot be readily explained on other grounds.
[Mh] MeSH terms primary: Deglutition Disorders/etiology
Fibromyalgia/diagnosis
Glossalgia/etiology
Weight Loss
[Mh] MeSH terms secundary: Aged, 80 and over
Female
Fibromyalgia/complications
Humans
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1510
[Cu] Class update date: 151109
[Lr] Last revision date:151109
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:150808
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000001163


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