Database : MEDLINE
Search on : Granuloma and Annulare [Words]
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[PMID]: 29221649
[Au] Autor:Charollais R; Aubin F; Roche-Kubler B; Puzenat E
[Ad] Address:EA3181, service de dermatologie, université de Bourgogne-Franche-Comté, CHU, 3, boulevard Fleming, 25030 Besançon, France.
[Ti] Title:Deux observations de granulome annulaire sous anti-PD1. [Two cases of granuloma annulare under anti-PD1 therapy].
[So] Source:Ann Dermatol Venereol;145(2):116-119, 2018 Feb.
[Is] ISSN:0151-9638
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:BACKGROUND: Granuloma annulare as a granulomatous cutaneous reaction may be drug-induced. Immune checkpoint inhibitors including programmed death-1 (PD-1) inhibitors show remarkable antitumor activity and are approved for melanoma and other cancers. Different immune-related adverse effects have been described. We report herein a rare adverse effect of anti-PD1 therapy given for metastatic melanoma : granuloma annulare. PATIENTS AND METHODS: Two women receiving pembrolizumab metastatic melanoma presented with granuloma annulare. The therapy was continued in both cases. In the first patient, granuloma annulare appeared and then subsided; in the second patient, the lesion resolved completely with topical corticosteroids. DISCUSSION: While there have been reported cases of sarcoidosis induced by immunotherapies, immunotherapy-induced granuloma annulare has not been described. The pathogenesis of drug-induced granulomatous reactions is thought to involve autoimmune dysregulation affecting T cells, especially Th1 cells, which lead to granuloma formation. Granuloma annulare should thus be considered a cutaneous adverse effect of anti-PD1 immunotherapy.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:In-Process

  2 / 1247 MEDLINE  
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[PMID]: 29488435
[Au] Autor:Naka F; Strober BE
[Ad] Address:a University of Connecticut School of Medicine , 263 Farmington Avenue Farmington , CT 06030 USA.
[Ti] Title:Methotrexate treatment of generalized granuloma annulare: A retrospective case series.
[So] Source:J Dermatolog Treat;:1-19, 2018 Feb 28.
[Is] ISSN:1471-1753
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Management of generalized granuloma annulare (GGA) poses challenges for both patients and dermatologists. Currently, there are no established first-line therapies for GGA and the available therapeutic modalities are based on individual case reports and a few small case series. Further, there are limited publications assessing the efficacy of methotrexate in treating GGA. OBJECTIVE: Evaluate the efficacy and adverse effects associated with methotrexate treatment of GGA. METHODS: Descriptive retrospective case series of 11 patients with GGA receiving methotrexate. RESULTS: 64% of patients receiving methotrexate noted improvement of their skin disease, of which 43% achieved complete clearance and 57% partial clearance. Initial dose of methotrexate ranged from 12.5-15mg weekly, administered either orally or subcutaneously. The majority of patients tolerated the treatment well. However, 18% of patients experienced the adverse effects of either GI upset or hair loss. LIMITATIONS: This case series lacks a control group and therefore has low internal validity. The lack of a disease severity and therapy responsiveness measurement tool made quantifying disease improvement inexact. CONCLUSION: Methotrexate can be a successful and well-tolerated treatment option for patients with generalized GA.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:Publisher
[do] DOI:10.1080/09546634.2018.1447075

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[PMID]: 29423961
[Au] Autor:Lewis DJ; Miranda RN; Oh CW; Hinojosa T; Medeiros LJ; Curry JL; Tetzlaff MT; Torres-Cabala CA; Nagarajan P; Ravandi-Kashani F; Duvic M
[Ad] Address:Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
[Ti] Title:Pruritic arthropod bite-like papules in T-cell large granular lymphocytic leukaemia and chronic myelomonocytic leukaemia.
[So] Source:Clin Exp Dermatol;, 2018 Feb 09.
[Is] ISSN:1365-2230
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:T-cell large granular lymphocytic leukaemia (T-LGLL) is a clinically indolent mature T-cell neoplasm characterized by a monoclonal population of CD3+ CD8+ cytotoxic T cells, which usually presents as neutropenia, anaemia and thrombocytopenia. Chronic myelomonocytic leukaemia (CMML) is a clonal haematopoietic disorder with features of both a myeloproliferative neoplasm and myelodysplastic syndrome (MDS). Patients with CMML exhibit a persistent peripheral blood monocytosis in addition to myelodysplastic features. Because of the rarity of T-LGLL, its cutaneous manifestations are poorly documented, but include vasculitis, vasculopathy, persistent ulcerations, generalized pruritus and disseminated granuloma annulare. Various types of skin lesions have been observed in patients with CMML and reportedly occur in approximately 10% of cases. We report the extraordinary case of a patient with MDS who developed T-LGLL, and subsequently the MDS progressed to CMML. The patient then developed diffuse arthropod bite-like papules and intractable pruritus.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180209
[Lr] Last revision date:180209
[St] Status:Publisher
[do] DOI:10.1111/ced.13401

  4 / 1247 MEDLINE  
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[PMID]: 29352388
[Au] Autor:Terziroli Beretta-Piccoli B; Mainetti C; Peeters MA; Laffitte E
[Ad] Address:Epatocentro Ticino, Lugano, Switzerland.
[Ti] Title:Cutaneous Granulomatosis: a Comprehensive Review.
[So] Source:Clin Rev Allergy Immunol;54(1):131-146, 2018 Feb.
[Is] ISSN:1559-0267
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Cutaneous granulomatosis is a heterogeneous group of diseases, characterized by a skin inflammatory reaction triggered by a wide variety of stimuli, including infections, foreign bodies, malignancy, metabolites, and chemicals. From a pathogenic point of view, they are divided into non-infectious and infectious granulomas. Pathophysiological mechanisms are still poorly understood. Non-infectious granulomatous skin diseases include granuloma annulare, necrobiosis lipoidica, rheumatic nodules, foreign body granulomas, cutaneous sarcoidosis, and interstitial granulomatous dermatitis. Necrobiosis lipoidica is more frequent in diabetic patients. Infectious granulomas of the skin are caused by mycobacteria, in particular Mycobacterium tuberculosis or atypical mycobacteria; parasites, such as Leishmania; or fungi. Pathogenic mechanisms of M. tuberculosis-related granuloma are discussed. From a clinical point of view, it is useful to divide cutaneous granulomatosis into localized and more disseminated forms, although this distinction can be sometimes artificial. Three types of localized granulomatous lesions can be distinguished: palisaded granulomas (granuloma annulare, necrobiosis lipoidica, and rheumatoid nodules), foreign body granulomas, and infectious granulomas, which are generally associated with localized infections. Disseminated cutaneous granulomas can be divided into infectious, in particular tuberculosis, and non-infectious forms, among which sarcoidosis and interstitial granulomatous dermatitis. From a histological point of view, the common denominator is the presence of a granulomatous inflammatory infiltrate in the dermis and/or hypodermis; this infiltrate is mainly composed of macrophages grouped into nodules having a nodular, palisaded or interstitial architecture. Finally, we propose which diagnostic procedure should be performed when facing a patient with a suspected cutaneous granulomatosis.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1801
[Cu] Class update date: 180209
[Lr] Last revision date:180209
[St] Status:In-Process
[do] DOI:10.1007/s12016-017-8666-8

  5 / 1247 MEDLINE  
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[PMID]: 29328553
[Au] Autor:Liersch J; Rohdenburg C; Duckheim C; Schaller J
[Ad] Address:Dermatopathology Laboratory, Duisburg, Germany.
[Ti] Title:Skin-colored papules on the elbows with a granuloma-annulare-like histological pattern.
[So] Source:J Dtsch Dermatol Ges;16(2):230-232, 2018 Feb.
[Is] ISSN:1610-0387
[Cp] Country of publication:Germany
[La] Language:eng
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1801
[Cu] Class update date: 180208
[Lr] Last revision date:180208
[St] Status:In-Data-Review
[do] DOI:10.1111/ddg.13424

  6 / 1247 MEDLINE  
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[PMID]: 29318643
[Au] Autor:Satta R; Biondi G; Puggioni GM; Montesu MA; Rongioletti F
[Ad] Address:Department of Surgical, Microsurgical and Medical Sciences, Unit of Dermatology, University of Sassari, Sassari, Italy.
[Ti] Title:Malignancy-associated generalized perforating granuloma annulare.
[So] Source:Clin Exp Dermatol;43(2):219-221, 2018 Mar.
[Is] ISSN:1365-2230
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180202
[Lr] Last revision date:180202
[St] Status:In-Data-Review
[do] DOI:10.1111/ced.13373

  7 / 1247 MEDLINE  
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SciELO Brazil full text

[PMID]: 29186265
[Au] Autor:Magalhães GM; Guimarães CF; Paula MC
[Ad] Address:Dermatology Clinic, Santa Casa de Misericórdia de Belo Horizonte - Belo Horizonte, MG, Brazil.
[Ti] Title:Case for diagnosis. Patch granuloma annulare.
[So] Source:An Bras Dermatol;92(3):419-420, 2017 May-Jun.
[Is] ISSN:1806-4841
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:A 59-year-old woman reported a 20-day history of slightly scaly erythematous infiltrated patches on her palms and soles with a histopathological result which was consistent with interstitial-pattern granuloma annulare, clinically classified as patch granuloma annulare. This is a rare clinical variant of granuloma annulare, with an unknown incidence and characteristic clinical and histopathological features. The patient evolved with a complete remission of the lesions after biopsy and the use of high-potency topical corticosteroid.
[Mh] MeSH terms primary: Granuloma Annulare/pathology
[Mh] MeSH terms secundary: Administration, Topical
Adrenal Cortex Hormones/administration & dosage
Female
Granuloma Annulare/drug therapy
Humans
Middle Aged
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Adrenal Cortex Hormones)
[Em] Entry month:1801
[Cu] Class update date: 180131
[Lr] Last revision date:180131
[Js] Journal subset:IM
[Da] Date of entry for processing:171130
[St] Status:MEDLINE

  8 / 1247 MEDLINE  
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[PMID]: 29205476
[Au] Autor:Thomas C; Morley K; Schmidt B; Hussain S
[Ad] Address:Harvard Combined Medicine and Dermatology Residency Program, Boston Children's Hospital, Boston, MA, USA.
[Ti] Title:Subcutaneous granuloma annulare involving the scalp.
[So] Source:Pediatr Dermatol;35(1):e72-e73, 2018 Jan.
[Is] ISSN:1525-1470
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Subcutaneous granuloma annulare (SGA) is an uncommon subtype of granuloma annulare. There are few reports of this entity solely affecting the scalp. We report a case of biopsy-proven SGA in a 21-month-old boy with six asymptomatic, rock-hard scalp nodules.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180122
[Lr] Last revision date:180122
[St] Status:In-Process
[do] DOI:10.1111/pde.13321

  9 / 1247 MEDLINE  
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SciELO Brazil full text

[PMID]: 29267455
[Au] Autor:Muylaert BPB; Almada R; Vasconcelos RCF
[Ad] Address:Department of Dermatology of the Universidade de Santo Amaro (UNISA) - Santo Amaro (SP), Brazil.
[Ti] Title:Granuloma annulare treated with narrowband UVB phototherapy.
[So] Source:An Bras Dermatol;92(5 Suppl 1):82-84, 2017.
[Is] ISSN:1806-4841
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:Granuloma annulare is a benign cutaneous inflammatory disease, whose lesions have spontaneous improvement in two years in 50% of cases, but there is recurrence in 40% of patients. Treatment may be topical, intralesional or systemic. The use of phototherapy with narrowband UVB is highlighted, whose mechanism of action in this disease is still unclear, probably related to the inhibition of T lymphocytes. Herein, a case of a disseminated granuloma annulare of difficult therapeutic management is described. It was treated with narrowband UVB phototherapy twice a week for six months, with good clinical improvement, being a good low-risk therapeutic option and that, in this case, provided quick and satisfactory response.
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1712
[Cu] Class update date: 171224
[Lr] Last revision date:171224
[St] Status:In-Process

  10 / 1247 MEDLINE  
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[PMID]: 29241760
[Au] Autor:Seremet S; Gurel MS
[Ad] Address:Department of Dermatology, Ataturk Training and Research Hospital, Izmir, Turkey.
[Ti] Title:Miscellaneous skin disease and the metabolic syndrome.
[So] Source:Clin Dermatol;36(1):94-100, 2018 Jan - Feb.
[Is] ISSN:1879-1131
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The link between the metabolic syndrome (MetS) and skin diseases is increasingly important, with new associations being discovered. The association between MetS and psoriasis or MetS and hidradenitis suppurativa is well known, although the relationship between MetS and various autoimmune or inflammatory diseases has only recently attracted interest. Some inflammatory skin diseases, such as vitiligo, scleredema, recurrent aphthous stomatitis, Behçet disease, rosacea, necrobiosis lipoidica, granuloma annulare, skin tags, knuckle pads, and eruptive xanthomas, have possible associations with MetS. In this review, we examine the state of knowledge involving the relationship between MetS and these dermatologic diseases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171215
[Lr] Last revision date:171215
[St] Status:In-Process


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