Database : MEDLINE
Search on : Gynatresia [Words]
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[PMID]: 29072881
[Au] Autor:Sunday-Adeoye I; Eni UE; Ekwedigwe KC; Daniyan BAC; Abodunrin ON; Isikhuemen ME; Eliboh MO; Uguru SM
[Ad] Address:National Obstetric Fistula Centre, Abakaliki, Nigeria.
[Ti] Title:Case report of treatment with a sigmoid neovagina for a patient with vesicovaginal fistula and gynatresia.
[So] Source:Int J Gynaecol Obstet;, 2017 Oct 26.
[Is] ISSN:1879-3479
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171121
[Lr] Last revision date:171121
[St] Status:Publisher
[do] DOI:10.1002/ijgo.12364

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[PMID]: 28239797
[Au] Autor:Savilova AM; Farkhat KN; Yushina MN; Rudimova YV; Makiyan ZN; Adamyan LV
[Ad] Address:V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia. bushueva@gmail.com.
[Ti] Title:Characteristics of Multipotent Mesenchymal Stromal Cells Isolated from the Endometrium and Endometriosis Lesions of Women with Malformations of the Internal Reproductive Organs.
[So] Source:Bull Exp Biol Med;162(4):539-544, 2017 Feb.
[Is] ISSN:1573-8221
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We isolated and characterized cell cultures from eutopic endometrium and endometriotic lesions of women with malformations of the internal reproductive organs. The cells had fibroblast-like shape and intensively expressed CD90, CD73, CD105, CD44, CD146, and CD117 and were capable of induced adipogenic and osteogenic differentiation in vitro. The obtained cultures exhibited properties of multipotent mesenchymal stromal cells; at the same time, they demonstrated in vitro immunophenotypic differences from cell cultures of eutopic and ectopic endometrium of women without developmental abnormalities, which suggests their functional difference. The cells from eutopic endometrium and from ectopic endometriotic lesions can be used as the model for studying of the etiology and pathogenesis of endometriosis and for testing new drugs for this specific group of patients. Markers CD90 and CD117 were identified as promising molecules for the development of minimally invasive diagnostics of endometriosis based on cell cultures from eutopic endometrium.
[Mh] MeSH terms primary: Adipocytes/cytology
Endometriosis/pathology
Endometrium/abnormalities
Gynatresia/pathology
Mesenchymal Stromal Cells/cytology
Osteoblasts/cytology
[Mh] MeSH terms secundary: Adipocytes/metabolism
Adolescent
Adult
Biomarkers/metabolism
Cell Differentiation
Cell Shape
Endometriosis/diagnosis
Endometriosis/metabolism
Endometrium/metabolism
Female
Gene Expression
Gynatresia/diagnosis
Gynatresia/metabolism
Humans
Immunophenotyping
Mesenchymal Stromal Cells/metabolism
Osteoblasts/metabolism
Proto-Oncogene Proteins c-kit/genetics
Proto-Oncogene Proteins c-kit/metabolism
Thy-1 Antigens/genetics
Thy-1 Antigens/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Biomarkers); 0 (Thy-1 Antigens); EC 2.7.10.1 (Proto-Oncogene Proteins c-kit)
[Em] Entry month:1703
[Cu] Class update date: 171116
[Lr] Last revision date:171116
[Js] Journal subset:IM
[Da] Date of entry for processing:170228
[St] Status:MEDLINE
[do] DOI:10.1007/s10517-017-3656-7

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[PMID]: 28170094
[Au] Autor:Gan L; Duan H; Sun FQ; Xu Q; Tang YQ; Wang S
[Ad] Address:Department of Minimally Invasive Gynecologic Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
[Ti] Title:Efficacy of freeze-dried amnion graft following hysteroscopic adhesiolysis of severe intrauterine adhesions.
[So] Source:Int J Gynaecol Obstet;137(2):116-122, 2017 May.
[Is] ISSN:1879-3479
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To evaluate the efficacy of freeze-dried amnion graft for prevention of intrauterine adhesion (IUA) reformation after hysteroscopic adhesiolysis. METHODS: A prospective randomized controlled trial was conducted among 88 women with severe IUAs who underwent hysteroscopic adhesiolysis at Beijing Obstetrics and Gynecology Hospital between July 15, 2015, and July 1, 2016. All participants had a balloon inserted into the uterine cavity for 1 week. Sterilized freeze-dried amnion graft covered the balloon portion of the Foley catheter among patients allocated to the amnion group (n=44), whereas patients in the control group (n=44) did not receive the graft. Follow-up hysteroscopy was performed 3 months after surgery. Preoperative and postoperative IUA scores, menstruation scores, and pregnancy rates were assessed. RESULTS: Both groups exhibited reductions in IUA scores and improvements in menstruation scores following treatment (P<0.001 for each measure). Compared with the control group, the amnion group had a lower IUA score (P=0.032) and a higher menstruation score (P<0.001) at follow-up. By contrast, the rates of IUA reformation and pregnancy were not significantly different between the two groups. CONCLUSION: Use of freeze-dried amnion graft was effective in reducing IUA reformation and improving menstruation (according to pictorial blood-loss assessment chart) following hysteroscopic adhesiolysis of severe IUAs. ClinicalTrials.gov: (NCT02496052).
[Mh] MeSH terms primary: Amnion/transplantation
Gynatresia/surgery
Intrauterine Devices
Tissue Adhesions/surgery
[Mh] MeSH terms secundary: Adult
Female
Freeze Drying
Gynatresia/prevention & control
Humans
Hysteroscopy
Postoperative Complications
Prospective Studies
Tissue Adhesions/prevention & control
Transplants
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Entry month:1709
[Cu] Class update date: 170918
[Lr] Last revision date:170918
[Js] Journal subset:IM
[Da] Date of entry for processing:170208
[St] Status:MEDLINE
[do] DOI:10.1002/ijgo.12112

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[PMID]: 28148903
[Au] Autor:Wang X; Ma N; Sun Q; Huang C; Liu Y; Luo X
[Ad] Address:The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China, 510630.
[Ti] Title:Elevated NF-κB signaling in Asherman syndrome patients and animal models.
[So] Source:Oncotarget;8(9):15399-15406, 2017 Feb 28.
[Is] ISSN:1949-2553
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Asherman syndrome (intrauterine adhesion) is often associated with menstrual abnormalities, infertility and recurrent miscarriage in female. Currently the molecular mechanism regulating the pathogenesis of Asherman syndrome is not known. Here we revealed that the inflammatory factor NF-κB expression is significantly elevated in the endometrial samples of Asherman syndrome patients. To further study the molecular mechanisms, we established an Asherman syndrome rat model and confirmed the important role of NF-κB in the pathogenesis of Asherman syndrome. In addition, our rat model provided direct evidence that intrauterine adhesion results in impaired pregnancy, supporting the clinical association between intrauterine adhesion and mis-regulated pregnancy. Our result identified NF-κB as a novel pathogenesis factor of Asherman syndrome and provided new insights for the prevention and treatment of intrauterine adhesions in Asherman syndrome patients.
[Mh] MeSH terms primary: Disease Models, Animal
Endometrium/metabolism
Gynatresia/genetics
NF-kappa B/genetics
Signal Transduction/genetics
[Mh] MeSH terms secundary: Animals
Blotting, Western
Female
Gene Expression
Gynatresia/metabolism
Gynatresia/pathology
Humans
Immunohistochemistry
NF-kappa B/metabolism
Pregnancy
Rats
Reverse Transcriptase Polymerase Chain Reaction
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (NF-kappa B)
[Em] Entry month:1708
[Cu] Class update date: 170828
[Lr] Last revision date:170828
[Js] Journal subset:IM
[Da] Date of entry for processing:170203
[St] Status:MEDLINE
[do] DOI:10.18632/oncotarget.14853

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[PMID]: 27856386
[Au] Autor:Chen L; Zhang H; Wang Q; Xie F; Gao S; Song Y; Dong J; Feng H; Xie K; Sui L
[Ad] Address:Medical Center of Diagnosis and Treatment for Cervical Diseases, Obstetrics and Gynecology Hospital, Fudan University, and Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China.
[Ti] Title:Reproductive Outcomes in Patients With Intrauterine Adhesions Following Hysteroscopic Adhesiolysis: Experience From the Largest Women's Hospital in China.
[So] Source:J Minim Invasive Gynecol;24(2):299-304, 2017 Feb.
[Is] ISSN:1553-4669
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:STUDY OBJECTIVE: To analyze the reproductive outcome of hysteroscopic adhesiolysis and assess the diagnostic accuracy of transvaginal ultrasonography (TVS) in infertile women resulting from intrauterine adhesions (IUAs). DESIGN: Retrospective, cross-sectional study (Canadian Task Force classification II-2). SETTING: University tertiary referral center. PATIENTS: Three hundred and fifty-seven patients with mild, moderate, and severe IUAs who underwent hysteroscopic adhesiolysis between January 2012 and December 2015. INTERVENTIONS: Hysteroscopic adhesiolysis in the outpatient analgesic setting for infertility and IUAs. MEASUREMENTS AND MAIN RESULTS: Among the 357 patients (135 with mild IUAs, 116 with moderate IUAs, and 106 with severe IUAs) who underwent hysteroscopic adhesiolysis, 334 (93.6%) experienced a completely restored uterine cavity. The reproductive outcomes of 332 women (93%) were followed for an average duration of 27 ± 9 months, and the overall conception rate after hysteroscopic adhesiolysis was 48.2%, which decreased with increased IUA severity (mild, 60.7%; moderate, 53.4%; severe, 25%). The mean time to conception following hysteroscopic adhesiolysis was 9.7 ± 3.7 months. The miscarriage rate was 9.4%, and the live birth rate was no lower than 85.6%. Eleven patients (7.9%) had postpartum hemorrhage, including 6 (4.3%) due to adherent placenta and 3 (2.1%) due to placenta accreta. CONCLUSION: Hysteroscopic adhesiolysis is a feasible and effective way to improve fertility in patients with Asherman's syndrome.
[Mh] MeSH terms primary: Gynatresia
Hysteroscopy
Infertility, Female
Reproductive Health/statistics & numerical data
[Mh] MeSH terms secundary: Adult
China/epidemiology
Cross-Sectional Studies
Dissection/adverse effects
Dissection/methods
Female
Fertilization/physiology
Gynatresia/diagnosis
Gynatresia/epidemiology
Gynatresia/etiology
Gynatresia/surgery
Humans
Hysteroscopy/adverse effects
Hysteroscopy/methods
Infertility, Female/diagnosis
Infertility, Female/epidemiology
Infertility, Female/etiology
Outcome and Process Assessment (Health Care)
Retrospective Studies
Severity of Illness Index
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170717
[Lr] Last revision date:170717
[Js] Journal subset:IM
[Da] Date of entry for processing:161119
[St] Status:MEDLINE

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[PMID]: 27751746
[Au] Autor:Yazbeck C
[Ad] Address:Collège de Médecine, 3, avenue Victoria, 75004 Paris, France; Hôpital Foch, 40, rue Worth, 92150 Suresnes, France; Clinique Pierre-Cherest, 5, rue P.-Cherest, 92200 Neuilly-Sur-Seine, France. Electronic address: chadiyazbeck@yahoo.fr.
[Ti] Title:Cellules souches autologues en thérapie endométriale : espoir ou illusion ? [Autologus stem cells and endometrial therapy: Hope or illusion?]
[So] Source:Gynecol Obstet Fertil;44(11):616-617, 2016 Nov.
[Is] ISSN:1769-6682
[Cp] Country of publication:France
[La] Language:fre
[Mh] MeSH terms primary: Endometrium
Genital Diseases, Female/surgery
Stem Cell Transplantation
[Mh] MeSH terms secundary: Female
Gynatresia/surgery
Humans
Transplantation, Autologous
[Pt] Publication type:EDITORIAL
[Em] Entry month:1708
[Cu] Class update date: 170830
[Lr] Last revision date:170830
[Js] Journal subset:IM
[Da] Date of entry for processing:161019
[St] Status:MEDLINE

  7 / 150 MEDLINE  
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[PMID]: 27437311
[Au] Autor:Kaur G; Sinha M; Gupta R
[Ad] Address:Head of Department, Department of Obstetrics and Gynecology, Kasturba Hospital , Darya Ganj, New Delhi, India .
[Ti] Title:Postpartum Vaginal Stenosis Due to Chemical Vaginitis.
[So] Source:J Clin Diagn Res;10(5):QD03-4, 2016 May.
[Is] ISSN:2249-782X
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Acquired vaginal stenosis is a rare obstructing anomaly, which can be caused by use of chemicals in the vagina. A 21-year-old gravida 1 para 1, presented with secondary amenorrhea and inability to have sexual intercourse, after normal spontaneous vaginal delivery complicated by post partum bleeding. The delivery was conducted by untrained traditional birth attendant at home. The wash cloth soaked with caustic soda was packed in the patient's vagina and was left in situ for 10 days, which ultimately led to the severe scarring and stenosis of the vagina. Patient underwent surgical management and the extensive vaginal adhesions were excised and a patent vagina was reconstructed. Patient then reported successful vaginal intercourse without dyspareunia. Post partum vaginal stenosis due to chemical vaginitis is rare. These cases can be prevented by adequate training of untrained health care workers.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1607
[Cu] Class update date: 170220
[Lr] Last revision date:170220
[Da] Date of entry for processing:160721
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.7860/JCDR/2016/18373.7796

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[PMID]: 27267872
[Au] Autor:Korkmazer E; Tekin B; Solak N
[Ad] Address:Bursa Sevket Yilmaz Research and Training Hospital, Department of Gynecology and Obstetrics, Bursa, Turkey. Electronic address: ekorkmazer@yahoo.com.
[Ti] Title:Ultrasound guidance during hysteroscopic myomectomy in G1 and G2 Submucous Myomas: for a safer one step surgery.
[So] Source:Eur J Obstet Gynecol Reprod Biol;203:108-11, 2016 Aug.
[Is] ISSN:1872-7654
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Hysteroscopic myomectomy is the gold standard method for treatment of submucous fibroids. Hysteroscopic myomectomy techniques for removal of submucous fibroids still have controversies. In this study we aimed to describe usefulness of ultrasound guidance in hysteroscopic myomectomy for a safe and effective removal of submucous G1 and G2 fibroids. STUDY DESIGN: This is a multicentre study. 64 symptomatic patients with submucous fibroid underwent ultrasound guided hysteroscopic myomectomy. First we excised intrauterine dome of fibroid until reaching the level of cavity wall by the method of resectoscopic (electrosurgical resection using a loop electrode) slicing. Next remnant intramural node was squeezed by uterine contractions induced. After we had excised the intrauterine dome of fibroid by slicing method, we formed cavitation for the intramural part (newly raised myoma dome). The cavity was filled with distension solution and we evaluated the margins of the uterus and the margins of the myoma by sonographically. Then the myoma was excised under ultrasonographic guidance by transabdominal probe. We obtained a regular uterine cavity. RESULTS: Mean operation time was 42±7min. Mean Mannitol volume was 4.3±1.7l and the mean intraoperational fluid deficit was 500ml. Not in any case uterine perforation was occurred. All fibroids removed totally. In 8 (19%) cases intrauterine synechiae detected and all these synechiaes were incised by a scissor during hysteroscopy. CONCLUSION: There is still no single technique proven to be unequivocally superior to the others for treating fibroids with intramural development (G1-G2). Ultrasound guided hysteroscopy seems to be an effective and safe method for resection of G1 and G2 fibroids.
[Mh] MeSH terms primary: Endosonography/adverse effects
Intraoperative Complications/prevention & control
Leiomyomatosis/diagnostic imaging
Myometrium/diagnostic imaging
Uterine Myomectomy/adverse effects
Uterine Neoplasms/diagnostic imaging
Uterine Perforation/prevention & control
[Mh] MeSH terms secundary: Adult
Ambulatory Surgical Procedures/adverse effects
Female
Follow-Up Studies
Gynatresia/epidemiology
Gynatresia/etiology
Gynatresia/surgery
Humans
Intraoperative Complications/epidemiology
Intraoperative Complications/etiology
Leiomyomatosis/surgery
Middle Aged
Myometrium/surgery
Operative Time
Pilot Projects
Postoperative Complications/epidemiology
Postoperative Complications/etiology
Postoperative Complications/surgery
Prospective Studies
Risk
Turkey/epidemiology
Uterine Neoplasms/surgery
Uterine Perforation/epidemiology
Uterine Perforation/etiology
[Pt] Publication type:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Entry month:1704
[Cu] Class update date: 170413
[Lr] Last revision date:170413
[Js] Journal subset:IM
[Da] Date of entry for processing:160609
[St] Status:MEDLINE

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[PMID]: 27172642
[Au] Autor:Bae JY; Cha HH; Seong WJ
[Ti] Title:Fetal Spinal Deformity Caused by Uterine Synechiae Mimicking Severe Scoliosis: A Case Report.
[So] Source:J Reprod Med;61(3-4):171-4, 2016 Mar-Apr.
[Is] ISSN:0024-7758
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: A severely deformed vertebra is a matter of concern, particularly when it develops before 24 weeks of gestation, which may lead to compromised pulmonary function and neurological development. CASE: A 39-year-old, nulliparous woman presented at 19 weeks of gestation. Her uterus was snowman shaped due to uterine synechiae, and the fetus was confined in the upper section, where amniotic fluid was scanty. The fetal spine was flexed at the upper thoracic level at an angle greater than 90°, with the head flexed and touching the right shoulder throughout pregnancy. Cesarean section was performed at 29+3 weeks of gestation due to preterm labor. A radiograph acquired immediately postpartum showed only a mild degree of spinal flexion, and during the course of hospitalization for respiratory support the infant's spine straightened completely. The infant was discharged without any complications. CONCLUSION: Here, we report an unusual case of severe fetal spinal deformity observed in early fetal life, and the subsequent positive outcome. We therefore advise caution, following a careful evaluation and consultation, before arriving at a decision of termination.
[Mh] MeSH terms primary: Gynatresia/complications
Pregnancy Complications
Scoliosis
Spine/abnormalities
[Mh] MeSH terms secundary: Adult
Amniotic Fluid
Cesarean Section
Diagnosis, Differential
Female
Gestational Age
Humans
Infant, Newborn
Infant, Premature
Magnetic Resonance Imaging
Obstetric Labor, Premature
Pregnancy
Prenatal Diagnosis
Radiography
Spine/diagnostic imaging
Spine/embryology
Ultrasonography, Prenatal
Uterus
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1605
[Cu] Class update date: 161126
[Lr] Last revision date:161126
[Js] Journal subset:IM
[Da] Date of entry for processing:160514
[St] Status:MEDLINE

  10 / 150 MEDLINE  
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[PMID]: 27129970
[Au] Autor:Sanad AS; Aboulfotouh ME
[Ad] Address:Department of Obstetrics and Gynecology, Faculty of Medicine, Minia Maternity University Hospital, Minia University, Cournish El-Nile Street, Minia, Egypt. asasanad@hotmail.com.
[Ti] Title:Hysteroscopic adhesiolysis: efficacy and safety.
[So] Source:Arch Gynecol Obstet;294(2):411-6, 2016 Aug.
[Is] ISSN:1432-0711
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To evaluate the efficacy and safety of hysteroscopic adhesiolysis in patients with intrauterine adhesions (IUAs). SETTING: Minia Maternity University Hospital, Egypt. DESIGN: Prospective cohort study. PATIENTS: This study included 61 patients presented with infertility (primary or secondary) or recurrent pregnancy losses caused by IUAs. INTERVENTION(S): The adhesions were divided by semi-rigid scissors introduced under direct vision through hysteroscopy. Three months later, second-look hysteroscopy was performed. PRIMARY OUTCOME PARAMETERS: Primary outcome parameters were reproductive parameters (pregnancy rate, duration of pregnancies, life births rate, time lag between the intervention and diagnosis of pregnancy). SECONDARY OUTCOME PARAMETERS: Secondary outcome parameters were the changes in post-operative menstrual pattern, number and duration of intervention and type of intra- and post-operative complications. RESULT(S): Pregnancy rate changed from 18 to 65.5 %, while live birth rate improved from 14.7 to 36 %. The mean time until the first conception was 10.2 months (range 2-60 months) after the operation. There was significant negative correlation between the degree of IUAs and the improvement in reproductive performance. Hysteroscopic adhesiolysis significantly improved menstrual pattern in 60.7 % of patients complaining of hypomenorrhea or amenorrhea. (p = 0.0017). The average operative time was 29 ± 10.2 (10-52) min and the hospital stay was 12.5 ± 2.1 (9-24) h. Uterine perforation occurred on 3 (4.9 %), and cervical laceration occurred in one case (1.6 %). CONCLUSION(S): Hysteroscopic adhesiolysis of IUAs is safe and effective in terms of reproductive outcome. The outcome is significantly affected by degree of intrauterine adhesions rather than the main complaint before the procedure.
[Mh] MeSH terms primary: Gynatresia/surgery
Hysteroscopy/methods
Infertility, Female/surgery
Tissue Adhesions/surgery
Uterine Diseases/surgery
[Mh] MeSH terms secundary: Adult
Egypt
Female
Fertilization/physiology
Humans
Hysteroscopy/adverse effects
Infertility, Female/etiology
Menstruation
Outcome and Process Assessment (Health Care)
Pregnancy
Pregnancy Outcome
Pregnancy Rate
Prospective Studies
Tissue Adhesions/etiology
Uterine Diseases/complications
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170809
[Lr] Last revision date:170809
[Js] Journal subset:IM
[Da] Date of entry for processing:160501
[St] Status:MEDLINE
[do] DOI:10.1007/s00404-016-4107-9


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