Database : MEDLINE
Search on : HIV and Seropositivity [Words]
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[PMID]: 29476708
[Au] Autor:Pina AF; Matos VTG; Bonin CM; Dal Fabbro MMFJ; Tozetti IA
[Ad] Address:Universidade Federal do Mato Grosso do Sul, Faculdade de Medicina, Campo Grande, MS, Brazil.
[Ti] Title:Non-polarized cytokine profile of a long-term non-progressor HIV infected patient.
[So] Source:Braz J Infect Dis;, 2018 Feb 21.
[Is] ISSN:1678-4391
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:The HIV-1 initial viral infection may present diverse clinical and laboratory course and lead to rapid, intermediate, or long-term progression. Among the group of non-progressors, the elite controllers are those who control the infection most effectively, in the absence of antiretroviral therapy (ART). In this paper, the TH1, TH2 and TH17 cytokines profiles are described, as well as clinical and laboratory aspects of an HIV-infected patient with undetectable viral load without antiretroviral therapy. Production of IL-6, IL-10, TNF-α, IFN-γ, and IL-17 was detected; in contrast IL-4 was identified. Host-related factors could help explain such a level of infection control, namely the differentiated modulation of the cellular immune response and a non-polarized cytokine response of the TH1 and TH2 profiles.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher

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[PMID]: 29157611
[Au] Autor:Simpson D
[Ad] Address:North Shore Hospital, Private Bag 93-503, Takapuna, Auckland 0740, New Zealand. Electronic address: david.simpson@waitematadhb.govt.nz.
[Ti] Title:Epidemiology of Castleman Disease.
[So] Source:Hematol Oncol Clin North Am;32(1):1-10, 2018 02.
[Is] ISSN:1558-1977
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Castleman disease is a rare entity, including unicentric Castleman disease (UCD), human herpesvirus-8 plus Castleman disease (HHV-8+MCD), and idiopathic multicentric Castleman disease (iMCD). UCD is the most common at 16 per million person years and occurs at every age. HHV-8+MCD incidence varies widely, mostly affecting human immunodeficiency virus-positive men. iMCD is likely a more heterogeneous disease with an estimated incidence of 5 per million person years. Improved definitions should improve understanding of the epidemiology of Castleman disease and its subtypes.
[Mh] MeSH terms primary: Castleman Disease/classification
Castleman Disease/epidemiology
[Mh] MeSH terms secundary: Female
HIV Seropositivity/complications
HIV Seropositivity/epidemiology
Herpesviridae Infections/classification
Herpesviridae Infections/epidemiology
Herpesvirus 8, Human
Humans
Incidence
Male
Sex Factors
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1801
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[Js] Journal subset:IM
[Da] Date of entry for processing:171122
[St] Status:MEDLINE

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[PMID]: 29408860
[Au] Autor:Stockdale L; Nash S; Nalwoga A; Painter H; Asiki G; Fletcher H; Newton R
[Ad] Address:London School of Hygiene and Tropical Medicine, Faculty of Infectious and Tropical Diseases, London, United Kingdom.
[Ti] Title:Human cytomegalovirus epidemiology and relationship to tuberculosis and cardiovascular disease risk factors in a rural Ugandan cohort.
[So] Source:PLoS One;13(2):e0192086, 2018.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Human cytomegalovirus (HCMV) infection has been associated with increased mortality, specifically cardiovascular disease (CVD), in high-income countries (HICs). There is a paucity of data in low- and middle-income countries (LMICs) where HCMV seropositivity is higher. Serum samples from 2,174 Ugandan individuals were investigated for HCMV antibodies and data linked to demographic information, co-infections and a variety of CVD measurements. HCMV seropositivity was 83% by one year of age, increasing to 95% by five years. Female sex, HIV positivity and active pulmonary tuberculosis (TB) were associated with an increase in HCMV IgG levels in adjusted analyses. There was no evidence of any associations with risk factors for CVD after adjusting for age and sex. HCMV infection is ubiquitous in this rural Ugandan cohort from a young age. The association between TB disease and high HCMV IgG levels merits further research. Known CVD risk factors do not appear to be associated with higher HCMV antibody levels in this Ugandan cohort.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1802
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:In-Process
[do] DOI:10.1371/journal.pone.0192086

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[PMID]: 27773665
[Au] Autor:Kunisaki KM; Niewoehner DE; Collins G; Aagaard B; Atako NB; Bakowska E; Clarke A; Corbelli GM; Ekong E; Emery S; Finley EB; Florence E; Infante RM; Kityo CM; Madero JS; Nixon DE; Tedaldi E; Vestbo J; Wood R; Connett JE; INSIGHT START Pulmonary Substudy Group
[Ad] Address:Minneapolis Veterans Affairs Health Care System, Minneapolis, MN, USA; University of Minnesota, Minneapolis, MN, USA. Electronic address: kunis001@umn.edu.
[Ti] Title:Pulmonary effects of immediate versus deferred antiretroviral therapy in HIV-positive individuals: a nested substudy within the multicentre, international, randomised, controlled Strategic Timing of Antiretroviral Treatment (START) trial.
[So] Source:Lancet Respir Med;4(12):980-989, 2016 12.
[Is] ISSN:2213-2619
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Observational data have been conflicted regarding the potential role of HIV antiretroviral therapy (ART) as a causative factor for, or protective factor against, COPD. We therefore aimed to investigate the effect of immediate versus deferred ART on decline in lung function in HIV-positive individuals. METHODS: We did a nested substudy within the randomised, controlled Strategic Timing of Antiretroviral Treatment (START) trial at 80 sites in multiple settings in 20 high-income and low-to-middle-income countries. Participants were HIV-1 infected individuals aged at least 25 years, naive to ART, with CD4 T-cell counts of more than 500 per µL, not receiving treatment for asthma, and without recent respiratory infections (baseline COPD was not an exclusion criterion). Participants were randomly assigned to receive ART (an approved drug combination derived from US Department of Health and Human Services guidelines) either immediately, or deferred until CD4 T-cell counts decreased to 350 per µL or AIDS developed. The randomisation was determined by participation in the parent START study, and was not specific to the substudy. Because of the nature of our study, site investigators and participants were not masked to the treatment group assignment; however, the assessors who reviewed the outcomes were masked to the treatment group. The primary outcome was the annual rate of decline in lung function, expressed as the FEV slope in mL/year; spirometry was done annually during follow-up for up to 5 years. We analysed data on an intention-to-treat basis, and planned separate analyses in smokers and non-smokers because of the known effects of smoking on FEV decline. The substudy was registered at ClinicalTrials.gov number NCT01797367. FINDINGS: Between March 11, 2010, and Aug 23, 2013, we enrolled 1026 participants to our substudy, who were then randomly assigned to either immediate (n=518) or deferred (n=508) ART. Median baseline characteristics included age 36 years (IQR 30-44), CD4 T-cell count 648 per µL (583-767), and HIV plasma viral load 4·2 log copies per mL (3·5-4·7). 29% were female and 28% were current smokers. Median follow-up time was 2·0 years (IQR 1·9-3·0). We noted no differences in FEV slopes between the immediate and deferred ART groups either in smokers (difference of -3·3 mL/year, 95% CI -38·8 to 32·2; p=0·86) or in non-smokers (difference of -5·6 mL/year, -29·4 to 18·3; p=0·65) or in pooled analyses adjusted for smoking status at each study visit (difference of -5·2 mL/year, -25·1 to 14·6; p=0·61). INTERPRETATION: The timing of ART initiation has no major short-term effect on rate of lung function decline in HIV-positive individuals who are naive to ART, with CD4 T-cell counts of more than 500 per µL. In light of updated WHO recommendations that all HIV-positive individuals should be treated with ART, regardless of their CD4 T-cell count, our results suggest an absence of significant pulmonary harm with such an approach. FUNDING: US National Heart Lung and Blood Institute, US National Institute of Allergy and Infectious Diseases, Division of AIDS, Agence Nationale de Recherches sur le SIDA et les Hipatites Virales (France), Australian National Health and Medical Research Council, Danish National Research Foundation, European AIDS Treatment Network, German Ministry of Education and Research, UK Medical Research Council and National Institute for Health Research, and US Veterans Health Administration Office of Research and Development.
[Mh] MeSH terms primary: Anti-HIV Agents/administration & dosage
HIV Seropositivity/drug therapy
Time-to-Treatment
[Mh] MeSH terms secundary: Adult
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes/virology
Drug Administration Schedule
Female
Follow-Up Studies
HIV Seropositivity/physiopathology
Humans
Lung/physiopathology
Lung/virology
Male
Respiratory Function Tests
Viral Load/drug effects
[Pt] Publication type:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Name of substance:0 (Anti-HIV Agents)
[Em] Entry month:1712
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[Js] Journal subset:IM
[Da] Date of entry for processing:161025
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE

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[PMID]: 29504505
[Au] Autor:Dias SS; Mbofana F; Cassy SR; Dias S; Augusto GF; Agadjanian V; Martins MRO
[Ad] Address:a EpiDoC Unit, Centro de Estudos de Doenças Crónicas da NOVA Medical School , Universidade Nova de Lisboa , Lisboa , Portugal.
[Ti] Title:Estimating risk factors for HIV infection among women in Mozambique using population-based survey data.
[So] Source:Afr J AIDS Res;17(1):62-71, 2018 Mar.
[Is] ISSN:1727-9445
[Cp] Country of publication:South Africa
[La] Language:eng
[Ab] Abstract:The use of population-based survey data together with sound statistical methods can enhance better estimation of HIV risk factors and explain variations across subgroups of the population. The distribution and determinants of HIV infection in populations must be taken into consideration. We analysed data from the HIV Prevalence and Behaviour Survey in Mozambique aiming to find risk factors associated with HIV infection among Mozambican women. The paper provides a complex survey logistic regression model to explain the variation in HIV seropositivity using demographic, socio-economic and behavioural factors. Results show that women aged 25-29 years, living in female-headed households, living in richer households and those widowed, divorced or not living with a partner have higher odds of being HIV-positive. Findings from our study provide a unique and integrated perspective on risk factors for being HIV-positive among Mozambican women and could support the implementation of programmes aiming to reduce HIV infection in Mozambique.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:In-Process
[do] DOI:10.2989/16085906.2017.1405824

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[PMID]: 29425918
[Au] Autor:Egbert AR; Biswal B; Karunakaran K; Gohel S; Pluta A; Wolak T; Szymanska B; Firlag-Burkacka E; Sobanska M; Gawron N; Bienkowski P; Sienkiewicz-Jarosz H; Scinska-Bienkowska A; Bornstein R; Rao S; Lojek E
[Ad] Address:The Faculty of Psychology, University of Warsaw, Stawki 5/7, 00-183 Warsaw, Poland; The Department of Biomedical Engineering, New Jersey Institute of Technology, University Heights Newark, NJ 07102, USA. Electronic address: anna.egbert@hiphealth.ca.
[Ti] Title:Age and HIV effects on resting state of the brain in relationship to neurocognitive functioning.
[So] Source:Behav Brain Res;344:20-27, 2018 Feb 06.
[Is] ISSN:1872-7549
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:This study examined the effects of age and HIV infection on the resting state (RS) functional connectivity (FC) of the brain and cognitive functioning. The objective was to evaluate the moderating role of age and HIV on the relationship between RS-FC and cognition. To examine RS-FC we implemented the Independent Component Analysis (ICA) and Regional Homogeneity (ReHo). Neurocognition was evaluated with comprehensive battery of standardized neuropsychological tests. Age and HIV were entered as the independent variables. The independent effects of age, HIV, and interaction effects of age-HIV on RS-fMRI measures (ICA, ReHo) were tested in 108 participants (age M = 42). RS-FC indices that exhibited age-HIV interactions were entered into further analysis. Bivariate correlation analysis was performed between the retained RS-FC indices and T-scores of neurocognitive domains (Attention, Executive, Memory, Psychomotor, Semantic Skills). Multivariate regression modeling determined the impact of age and HIV on these relationships. We found that in the ICA measures, HIV-seropositivity was decreasing RS-FC in the left middle occipital gyrus (p < .001). Age-HIV interaction was observed in the left superior frontal gyrus (LSupFrontG), where FC was decreasing with age in HIV+ (p < .001) and increasing in HIV- (p = .031). ReHo indices did not reveal significant effects. HIV strengthened the relationship between RS-FC in LSupFrontG, Memory and Psychomotor Factor scores. Aging weakened those relationships only in control group. In sum, age-HIV interaction effects are prominent rather in remote than local RS-FC. Seroconversion strengthens relationships between intrinsic brain activity and neurocognition, but no acceleration with years of age was noted in HIV+ individuals.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180303
[Lr] Last revision date:180303
[St] Status:Publisher

  7 / 23831 MEDLINE  
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[PMID]: 29482448
[Au] Autor:Dolan G; Chauhan M; Foster K; Basta M; Bushby S; White C; Verlander NQ; Gorton R
[Ad] Address:1 EPIET Associate Programme, Public Health England, UK FETP, Newcastle-upon-Tyne, UK.
[Ti] Title:Factors associated with repeat diagnosis of syphilis in genitourinary medicine (GUM) clinic attendees in the North East of England, 2002-2014.
[So] Source:Int J STD AIDS;:956462418757554, 2018 Jan 01.
[Is] ISSN:1758-1052
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:This study aimed to identify factors associated with repeat syphilis infection in North East England, in order to inform local prevention and control opportunities. We undertook a case-case study comparing individuals diagnosed with single or multiple episodes of syphilis infection within genitourinary medicine (GUM) clinics in NE England (12 clinics serving a population of 2.5 million). Study cases were verified as having had true re-infection by a GUM clinician (using serological and/or clinical parameters) and control cases (3 per case) frequency matched to cases by age and year of presentation. The odds of exposure to sexual behavioural and clinical factors were compared for cases and control cases using stepwise multivariable logistic regression. We included 66 cases and 235 control cases. The majority of cases (62/66) and control cases (165/235) were men who had sex with men (MSM). Data were missing for 0-64% of cases across different variables. Following multivariable analysis HIV seropositivity (OR 23.3, 95% CI 4.32-125.9), failure to attend follow-up (OR 4.63, 95% CI 1.11-19.31), stage of infection and deprivation were associated with re-infection ( p < 0.001). In this study, HIV seropositivity and failure to attend follow-up were associated with re-infection with syphilis. Actions targeted at these groups may help to reduce ongoing transmission.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:Publisher
[do] DOI:10.1177/0956462418757554

  8 / 23831 MEDLINE  
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[PMID]: 28457201
[Au] Autor:Hoyos Miller J; Clarke E; Patel R; Kell P; Desai M; Nardone A
[Ad] Address:1 Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Spain.
[Ti] Title:How are sexual health clinics in England managing men who have sex with men who refuse to be tested for HIV?
[So] Source:Int J STD AIDS;28(13):1305-1310, 2017 11.
[Is] ISSN:1758-1052
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The aim of this study was to ascertain the existence of written policies and common clinical practices in sexual health clinics in England for the management of men who have sex with men who refuse to test for HIV. All sexual health clinics in England ( n = 223) were invited to complete an online questionnaire in August-September 2014. The questionnaire covered the four domains of clinic policies, management practices, training and monitoring. We assess differences by region. Overall, 92 clinics participated. Only three clinics reported having a written policy. In contrast, most reported having a common agreed practice (94% in London vs. 71.6% elsewhere). When encountering a refusal, 72.2% of the London clinics and 53.4% of the clinics from elsewhere offered a less invasive option. Few clinics (17.4%) provided information on home sampling kits and 74.4% informed about other testing options. Eighty-seven per cent of the clinics recorded the occurrence of refusals, but only 37.8% reviewed the collected data. Providing staff with training was more common in London (94.1% vs. 73.8%). Clear policies should be developed to guide professionals when encountering men who have sex with men who refuse an HIV test. Offering less invasive testing options and information on alternative testing options could be easily introduced into routine practice. Efforts should be made to review monitoring data in order to identify implications of test refusals and introduce improvements in management of refusals.
[Mh] MeSH terms primary: HIV Infections/diagnosis
Health Policy
Homosexuality, Male/statistics & numerical data
Mass Screening/utilization
Treatment Refusal/statistics & numerical data
[Mh] MeSH terms secundary: Ambulatory Care Facilities
England
HIV Infections/epidemiology
HIV Infections/prevention & control
HIV Infections/psychology
HIV Seropositivity
Humans
Male
Mass Screening/psychology
Practice Guidelines as Topic
Sexual Partners
Surveys and Questionnaires
Treatment Refusal/psychology
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[Js] Journal subset:IM; X
[Da] Date of entry for processing:170502
[St] Status:MEDLINE
[do] DOI:10.1177/0956462417704343

  9 / 23831 MEDLINE  
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[PMID]: 29480249
[Au] Autor:Rewri P; Sharma M; Vats DP; Singhal A
[Ad] Address:Department of Ophthalmology, Maharaja Agrasen Medical College, Agroha, Hisar, Haryana, India.
[Ti] Title:Seroprevalence, risk associations, and cost analysis of screening for viral infections among patients of cataract surgery.
[So] Source:Indian J Ophthalmol;66(3):394-399, 2018 Mar.
[Is] ISSN:1998-3689
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Purpose: The purpose of this study was to estimate the prevalence of blood-borne viral infections (triple H: HBV-hepatitis B virus, HCV-hepatitis C virus, and HIV-human immunodeficiency virus) among cataract patients, sought possible risk associations and discuss feasibility of universal preoperative screening. Methods: This prospective, cross-sectional study enrolled consecutive patients of senile cataract. They were screened by immunoassay-based rapid diagnostic card tests for blood-borne viral infections. Positive cases were confirmed with confirmatory ELISA tests. Seropositive patients were enquired about the exposure to possible risk associations for acquiring these infections. Cost of card test per patient was calculated. Results: The prevalence of seropositivity for triple H viral infections (HBV, HCV, and HIV) among patients of senile cataract was 5.9% (95% confidence interval [CI]: 5.3-6.6), and HCV was most common viral infection. The dental extraction was most common (54%; 95% CI:48-60) possible risk association. The total cost of primary screening per patient for triple H infections(HBV, HCV, and HIV) was $0.93. Conclusion: The prevalence of blood-borne viral infection among cataract patients is high in this area. Awareness of the prevalence of blood-borne viral infections in service area, along with knowledge of rate of accidental exposure and risk of transmission would help to understand cost-effectiveness of universal preoperative screening before cataract surgery.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[St] Status:In-Data-Review
[do] DOI:10.4103/ijo.IJO_726_17

  10 / 23831 MEDLINE  
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[PMID]: 28346077
[Au] Autor:Herbst JH; Mansergh G; Pitts N; Denson D; Mimiaga MJ; Holman J
[Ad] Address:a Division of HIV/AIDS Prevention , National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention , Atlanta , Georgia , USA.
[Ti] Title:Effects of Brief Messages About Antiretroviral Therapy and Condom Use Benefits Among Black and Latino MSM in Three U.S. Cities.
[So] Source:J Homosex;65(2):154-166, 2018.
[Is] ISSN:1540-3602
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:This pilot study examined effects of HIV prevention messages about self and partner benefits of antiretroviral therapy (ART) and condom effectiveness on increased intentions for behavior change. Data were from Messages4Men, a study examining prevention messages among 320 HIV-positive and 605 HIV-negative Black and Latino MSM. Men completed a computer-based assessment after message exposure, and multivariable models controlled for risky sex and demographics. A majority of HIV-positive men reported increased intentions for ART use; 22% reported partner benefit information was new. HIV-positive men with a detectable viral load had significantly greater adjusted odds of reporting intentions for ART use. Over half of HIV-negative MSM reported ART benefit information was new, and 88% reported increased intentions to discuss ART use with infected partners. Black MSM anticipated they would increase condom use in response to the self and partner benefit messages. Tailored messages on benefits of ART are needed for MSM.
[Mh] MeSH terms primary: Advertising as Topic
Anti-HIV Agents/therapeutic use
Condoms
HIV Infections/prevention & control
Homosexuality, Male
Mass Media
[Mh] MeSH terms secundary: Adult
African Americans
Cities
Condoms/utilization
HIV Seropositivity
Health Promotion
Hispanic Americans
Humans
Male
Pilot Projects
Safe Sex
Sexual Partners
Young Adult
[Pt] Publication type:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-HIV Agents)
[Em] Entry month:1802
[Cu] Class update date: 180221
[Lr] Last revision date:180221
[Js] Journal subset:IM
[Da] Date of entry for processing:170328
[St] Status:MEDLINE
[do] DOI:10.1080/00918369.2017.1311554


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