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Lemos, Marcílio Figueiredo
Moreira, Regina Celia
SciELO Brazil full text

[PMID]: 29236927
[Au] Autor:Caterino-de-Araujo A; Alves FA; Campos KR; Lemos MF; Moreira RC
[Ad] Address:Centro de Imunologia, Laboratório de Pesquisa em HTLV, Instituto Adolfo Lutz, Secretaria de Estado da Saúde de São Paulo, São Paulo, SP, Brasil.
[Ti] Title:Making the invisible visible: searching for human T-cell lymphotropic virus types 1 and 2 (HTLV-1 and HTLV-2) in Brazilian patients with viral hepatitis B and C.
[So] Source:Mem Inst Oswaldo Cruz;113(2):130-134, 2018 Feb.
[Is] ISSN:1678-8060
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:With this study, the authors hope to alert clinicians regarding the presence of human T-cell lymphotropic virus type 1 and 2 (HTLV-1/-2) infections in patients with viral hepatitis B and C in Brazil. HTLV-1/-2 were detected in 1.3% of hepatitis B virus (HBV)- and 5.3% of hepatitis C virus (HCV)-infected blood samples sent for laboratory viral load measurements. A partial association of human immunodeficiency virus (HIV)-1 and HTLV-1/-2 infection was detected in patients with HCV (HIV+, 27.3%), whereas this association was almost 100% in HBV-infected patients (HIV+, all except one). The high prevalence of HTLV-1/-2 infection among patients with hepatitis C was of concern, as HTLV-1/-2 could change the natural course of subsequent liver disease. The authors suggest including HTLV-1/-2 serology in the battery of tests used when following patients with viral hepatitis in Brazil, regardless of the HIV status.
[Mh] MeSH terms primary: HTLV-I Infections/diagnosis
HTLV-II Infections/diagnosis
Hepatitis B/complications
Hepatitis C/complications
[Mh] MeSH terms secundary: Brazil/epidemiology
HTLV-I Infections/complications
HTLV-I Infections/epidemiology
HTLV-II Infections/complications
HTLV-II Infections/epidemiology
Hepatitis B/epidemiology
Hepatitis C/epidemiology
Human T-lymphotropic virus 1/isolation & purification
Human T-lymphotropic virus 2/isolation & purification
Humans
Mandatory Reporting
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180215
[Lr] Last revision date:180215
[Js] Journal subset:IM
[Da] Date of entry for processing:171214
[St] Status:MEDLINE

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SciELO Brazil full text

[PMID]: 28343818
[Au] Autor:Campos KR; Gonçalves MG; Costa NA; Caterino-de-Araujo A
[Ad] Address:Secretaria de Estado da Saúde de São Paulo, Instituto Adolfo Lutz, Centro de Imunologia, São Paulo, SP, Brazil.
[Ti] Title:Comparative performances of serologic and molecular assays for detecting human T lymphotropic virus type 1 and type 2 (HTLV-1 and HTLV-2) in patients infected with human immunodeficiency virus type 1 (HIV-1).
[So] Source:Braz J Infect Dis;21(3):297-305, 2017 May - Jun.
[Is] ISSN:1678-4391
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:The present study evaluated several techniques currently available (commercial kits and in-house assays) for diagnosing human T lymphotropic viruses types 1 and 2 in two groups of patients enrolled at HIV/AIDS specialized care services in São Paulo: Group 1 (G1), n=1608, 1237 male/371 female, median age 44.3 years old, majority using highly active antiretroviral therapy (HAART); G2, n=1383, 930 male/453 female, median age of 35.6 years old, majority HAART naïve. Enzyme immunoassays [(EIA) Murex and Gold ELISA] were employed for human T lymphotropic viruses types 1 and 2 screening; Western blotting (WB), INNO-LIA (LIA), real-time PCR pol (qPCR), and nested-PCR-RFLP (tax) were used to confirm infection. Samples were considered human T lymphotropic viruses types 1 and 2 positive when there was reactivity using at least one of the four confirmatory assays. By serological screening, 127/2991 samples were positive or borderline, and human T lymphotropic virus infection was confirmed in 108 samples (three EIA-borderline): 56 human T lymphotropic virus type 1 [G1 (27)+G2 (29)]; 45 human T lymphotropic virus type 2 [G1 (21)+G2 (24)]; one human T lymphotropic virus type 1+human T lymphotropic virus type 2 (G2); six human T lymphotropic virus [G1 (2)+G2 (4)]. Although there were differences in group characteristics, human T lymphotropic viruses types 1 and 2 prevalence was similar [3.1% (G1) and 4.2% (G2), p=0.113]. The overall sensitivities of LIA, WB, qPCR, and PCR-RFLP were 97.2%, 82.4%, 68.9%, and 68.4%, respectively, with some differences among groups, likely due to the stage of human T lymphotropic virus infection and/or HAART duration. Indeterminate immunoblotting results were detected in G2, possibly due to the seroconversion period. Negative results in molecular assays could be explained by the use of HAART, the occurrence of defective provirus and/or the low circulating proviral load. In conclusion, when determining the human T lymphotropic virus infection, the findings highlight that there is a need to consider the blood samples with borderline results in screening assays. Of all the tested assays, LIA was the assay of choice for detecting human T lymphotropic virus type 1 and human T lymphotropic virus type 2 in human immunodeficiency virus type 1-infected patients.
[Mh] MeSH terms primary: HIV Infections/complications
HTLV-I Infections/diagnosis
HTLV-II Infections/diagnosis
[Mh] MeSH terms secundary: Adult
Blotting, Western
DNA, Viral/genetics
Enzyme-Linked Immunosorbent Assay
Female
HTLV-I Antibodies/blood
HTLV-I Infections/complications
HTLV-II Antibodies/blood
HTLV-II Infections/complications
Humans
Male
Real-Time Polymerase Chain Reaction
Sensitivity and Specificity
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Name of substance:0 (DNA, Viral); 0 (HTLV-I Antibodies); 0 (HTLV-II Antibodies)
[Em] Entry month:1710
[Cu] Class update date: 171003
[Lr] Last revision date:171003
[Js] Journal subset:IM
[Da] Date of entry for processing:170328
[St] Status:MEDLINE

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[PMID]: 28193549
[Au] Autor:Rodgers MA; Vallari AS; Harris B; Yamaguchi J; Holzmayer V; Forberg K; Berg MG; Kenmenge J; Ngansop C; Awazi B; Mbanya D; Kaptue L; Brennan C; Cloherty G; Ndembi N
[Ad] Address:Abbott Laboratories, Abbott Park, IL, USA. Electronic address: mary.rodgers@abbott.com.
[Ti] Title:Identification of rare HIV-1 Group N, HBV AE, and HTLV-3 strains in rural South Cameroon.
[So] Source:Virology;504:141-151, 2017 Apr.
[Is] ISSN:1096-0341
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Surveillance of emerging viral variants is critical to ensuring that blood screening and diagnostic tests detect all infections regardless of strain or geographic location. In this study, we conducted serological and molecular surveillance to monitor the prevalence and diversity of HIV, HBV, and HTLV in South Cameroon. The prevalence of HIV was 8.53%, HBV was 10.45%, and HTLV was 1.04% amongst study participants. Molecular characterization of 555 HIV-1 specimens identified incredible diversity, including 7 subtypes, 12 CRFs, 6 unclassified, 24 Group O and 2 Group N infections. Amongst 401 HBV sequences were found a rare HBV AE recombinant and two emerging sub-genotype A strains. In addition to HTLV-1 and HTLV-2 strains, sequencing confirmed the fifth known HTLV-3 infection to date. Continued HIV/HBV/HTLV surveillance and vigilance for newly emerging strains in South Cameroon will be essential to ensure diagnostic tests and research stay a step ahead of these rapidly evolving viruses.
[Mh] MeSH terms primary: HIV Infections/epidemiology
HIV-1/classification
HTLV-I Infections/epidemiology
Hepatitis B virus/genetics
Hepatitis B, Chronic/epidemiology
Human T-lymphotropic virus 1/genetics
Human T-lymphotropic virus 2/genetics
Human T-lymphotropic virus 3/genetics
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Viral/blood
Antigens, Viral/blood
Base Sequence
Cameroon/epidemiology
Child
Child, Preschool
DNA, Viral/genetics
Female
Genome, Viral/genetics
HIV Infections/virology
HIV-1/genetics
HTLV-I Infections/virology
Hepatitis B virus/classification
Hepatitis B virus/isolation & purification
Hepatitis B, Chronic/virology
Human T-lymphotropic virus 1/classification
Human T-lymphotropic virus 1/isolation & purification
Human T-lymphotropic virus 2/classification
Human T-lymphotropic virus 2/isolation & purification
Human T-lymphotropic virus 3/classification
Human T-lymphotropic virus 3/isolation & purification
Humans
Infant
Male
Middle Aged
Sequence Analysis, DNA
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antibodies, Viral); 0 (Antigens, Viral); 0 (DNA, Viral)
[Em] Entry month:1705
[Cu] Class update date: 170523
[Lr] Last revision date:170523
[Js] Journal subset:IM
[Da] Date of entry for processing:170215
[St] Status:MEDLINE

  4 / 1237 MEDLINE  
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Covas, Dimas Tadeu
Full text

[PMID]: 27589576
[Au] Autor:Slavov SN; Otaguiri KK; Smid J; de Oliveira AC; Casseb J; Martinez EZ; Covas DT; Eis-Hübinger AM; Kashima S
[Ad] Address:Faculty of Medicine of Ribeirão Preto, Blood Center of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
[Ti] Title:Human parvovirus 4 prevalence among HTLV-1/2 infected individuals in Brazil.
[So] Source:J Med Virol;89(4):748-752, 2017 Apr.
[Is] ISSN:1096-9071
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Human parvovirus 4 (PARV4), a Tetraparvovirus, has been largely found in HIV, HBV, or HCV infected individuals. However, there is no data for the PARV4 occurrence in Human T-lymphotropic virus (HTLV-1/2) infected individuals, despite similar transmission routes. Here, PARV4 viremia was evaluated in 130 HTLV infected patients under care of a Brazilian HTLV outpatient clinic. PARV4 viremia was detected in 6.2% of the HTLV-1 infected patients. Most PARV4 positives showed no evidence for parenterally transmitted infections. It is suggested that in Brazil, transmission routes of PARV4 are more complex than in Europe and North America and resemble those in Africa. J. Med. Virol. 89:748-752, 2017. © 2016 Wiley Periodicals, Inc.
[Mh] MeSH terms primary: HTLV-I Infections/complications
HTLV-II Infections/complications
Parvoviridae Infections/epidemiology
Parvovirus/isolation & purification
[Mh] MeSH terms secundary: Adult
Aged
Brazil/epidemiology
Female
Humans
Male
Middle Aged
Prevalence
Viremia/epidemiology
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170907
[Lr] Last revision date:170907
[Js] Journal subset:IM
[Da] Date of entry for processing:160903
[St] Status:MEDLINE
[do] DOI:10.1002/jmv.24673

  5 / 1237 MEDLINE  
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[PMID]: 26899860
[Au] Autor:Salehi M; Shokouhi Mostafavi SK; Ghasemian A; Gholami M; Kazemi-Vardanjani A; Rahimi MK
[Ad] Address:Medical Diagnostic Laboratory of Neyshabour, Center of Medical, Pathological and Genetic Diagnostic Services, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad Branch, Mashhad, Iran.
[Ti] Title:Seroepidemiology of HTLV-1 and HTLV-2 Infection in Neyshabur City, North-Eastern Iran, during 2010-2014.
[So] Source:Iran Biomed J;21(1):57-60, 2017 Jan.
[Is] ISSN:2008-823X
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:BACKGROUND: Retroviruses of human T-lymphotropic viruses (HTLV-1 and HTLV-2) have been demonstrated to be endemic in the north-eastern region of Iran. This study was aimed to determine the HTLV-1 and HTLV-2 prevalence among healthy individuals in Neyshabur City during 2010-2014. METHODS: A total of 8054 blood samples were collected from healthy participants in Neyshabur, North-Eastern Iran. The blood samples were screened for the presence of specific antibodies against HTLV-1 and HTLV-2 by using ELISA according to the manufacturer's instructions. RESULTS: The overall seropositivity rate for HTLV-1 and HTLV-2 was found to be 6.55% (528 out of 8054) among participants. CONCLUSION: Both HTLV-1 and HTLV-2 were demonstrated to be at a high rate in healthy individuals. However, a smaller number of asymptomatic carriers were found in this study, as compared to those identified in previous investigations in the city.
[Mh] MeSH terms primary: HTLV-I Antibodies/blood
HTLV-I Infections/epidemiology
HTLV-II Antibodies/blood
HTLV-II Infections/epidemiology
Human T-lymphotropic virus 1/isolation & purification
Human T-lymphotropic virus 2/isolation & purification
[Mh] MeSH terms secundary: Adolescent
Adult
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
HTLV-I Infections/virology
HTLV-II Infections/virology
Humans
Infant
Iran/epidemiology
Male
Prevalence
Seroepidemiologic Studies
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (HTLV-I Antibodies); 0 (HTLV-II Antibodies)
[Em] Entry month:1704
[Cu] Class update date: 170407
[Lr] Last revision date:170407
[Js] Journal subset:IM
[Da] Date of entry for processing:160223
[St] Status:MEDLINE

  6 / 1237 MEDLINE  
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[PMID]: 27980301
[Au] Autor:Kawano R; Niino D; Ohshima K
[Ad] Address:Second Department of Pathology, Kurume University School of Medicine.
[Ti] Title:Six Cases of CD20-Positive Adult T-Cell Leukemia.
[So] Source:J Clin Exp Hematop;56(2):119-125, 2016.
[Is] ISSN:1880-9952
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:Adult T-cell leukaemia/lymphoma (ATLL) is a neoplasm originating in mature CD4 peripheral T cells. However, rare cases of CD20 ATLL have been reported. Here, we describe six cases of CD20 ATLL diagnosed in our department. The median age was 79 years (range, 54-90 years); two patients were men, and four were women. Elevated lactate dehydrogenase was observed in four cases. All cases were lymphoma type and positive for human T-lymphotropic virus-1 (HTLV-1). HTLV-1 proviral DNA was detected in four cases. The Ann Arbor stage was I, II, or IV in one patient each and III in three patients. The clinical course was poor in almost all cases. Tumour cells were large in all cases, and flow cytometry revealed CD20 lymphoma cells in five of six cases. Immunohistochemistry revealed lymphoma cells positive for CD20, CD3, CD4, and CCR4 and negative for CD8, CD79a, and PAX5 in all cases. CD20 expression was lower than that in normal B cells. One case was initially misdiagnosed as diffuse large B-cell lymphoma. Thus, combined use of an antibody panel and molecular genetic studies is important to avoid misdiagnosing ATLL as B-cell lymphoma.
[Mh] MeSH terms primary: CD28 Antigens/biosynthesis
Gene Expression Regulation, Leukemic
HTLV-I Infections
HTLV-II Infections
Human T-lymphotropic virus 1
Human T-lymphotropic virus 2
Leukemia-Lymphoma, Adult T-Cell
Neoplasm Proteins/biosynthesis
[Mh] MeSH terms secundary: Aged
Aged, 80 and over
Female
HTLV-I Infections/diagnosis
HTLV-I Infections/metabolism
HTLV-II Infections/diagnosis
HTLV-II Infections/metabolism
Humans
Leukemia-Lymphoma, Adult T-Cell/diagnosis
Leukemia-Lymphoma, Adult T-Cell/metabolism
Male
Middle Aged
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (CD28 Antigens); 0 (Neoplasm Proteins)
[Em] Entry month:1703
[Cu] Class update date: 171116
[Lr] Last revision date:171116
[Js] Journal subset:IM
[Da] Date of entry for processing:161217
[St] Status:MEDLINE

  7 / 1237 MEDLINE  
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Lopes, Carmen Luci Rodrigues
Martins, Regina Maria Bringel
SciELO Brazil full text

[PMID]: 27828621
[Au] Autor:Kozlowski AG; Matos MA; Carneiro MA; Lopes CL; Teles SA; Vicente CP; Martins RM
[Ad] Address:Universidade Federal de Goiás (UFG), Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.
[Ti] Title:SEROPREVALENCE OF HTLV IN A POPULATION OF HIV1-INFECTED PATIENTS IN MIDWESTERN BRAZIL.
[So] Source:Rev Inst Med Trop Sao Paulo;58:80, 2016 Nov 03.
[Is] ISSN:1678-9946
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:Human T-cell lymphotropic virus (HTLV) may affect the clinical course of human immunodeficiency virus 1 (HIV1). Both infections are common in endemic areas because these viruses share similar routes of transmission. The aim of this study was to estimate the seroprevalence of HTLV1/2 in a population of HIV1-infected patients in the state of Goiás, Midwestern Brazil. Of the 505 studied patients, four (0.79%) were positive for anti-HTLV1/2 by enzyme-linked immunosorbent assay (ELISA), with HTLV1 infection confirmed by line immunoassay (LIA) and polymerase chain reaction (PCR) in all of the ELISA-positive samples. No cases of HTLV2 infection were observed. The prevalence of HTLV1/HIV1 coinfection was 0.79% (4/505; 95% CI: 0.25-2.16). All the coinfected patients reported sexual risk behaviors and only one reported intravenous drug use. Sequencing of the viral long terminal repeat (LTR) region and phylogenetic analysis revealed that the four HTLV1 isolates belonged to the Transcontinental a subgroup of the Cosmopolitan (1a) subtype, the most frequent subgroup detected in Brazil. This study shows a low prevalence of HTLV1/2 in HIV1-infected patients in Midwestern Brazil.
[Mh] MeSH terms primary: Coinfection/epidemiology
HIV Infections/epidemiology
HTLV-I Infections/epidemiology
[Mh] MeSH terms secundary: Adult
Brazil/epidemiology
Enzyme-Linked Immunosorbent Assay
Female
Human T-lymphotropic virus 1/genetics
Human T-lymphotropic virus 1/immunology
Human T-lymphotropic virus 2/genetics
Human T-lymphotropic virus 2/immunology
Humans
Male
Middle Aged
Polymerase Chain Reaction
Prevalence
Seroepidemiologic Studies
Socioeconomic Factors
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1703
[Cu] Class update date: 170302
[Lr] Last revision date:170302
[Js] Journal subset:IM
[Da] Date of entry for processing:161110
[St] Status:MEDLINE

  8 / 1237 MEDLINE  
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[PMID]: 27650229
[Au] Autor:Rossheim AE; Cunningham TD; Troy SB
[Ad] Address:Center for Health Analytics and Discovery, Eastern Virginia Medical School, Norfolk, VA.
[Ti] Title:Human T-lymphotropic Virus Co-infections in Adults Infected With Human Immunodeficiency Virus.
[So] Source:Am J Med Sci;352(3):258-60, 2016 Sep.
[Is] ISSN:1538-2990
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Human T-lymphotropic virus type 1 or 2 (HTLV-1/2) co-infection in patients infected with the human immunodeficiency virus (HIV) can lead to increased morbidity. Because HTLV-1/2 shares a similar transmission route with HIV, HTLV-1/2 infection may be more prevalent in HIV-infected individuals. However, rates of HTLV-1/2 co-infection among HIV-infected individuals have not been studied recently in the United States. MATERIALS AND METHODS: We conducted a cross-sectional study using serum from 292 HIV-infected subjects from one clinic in Virginia. Serum samples were tested for co-infection with HTLV-1/2 by commercial ELISA; positive results were then confirmed via western blot, which also differentiated between HTLV-1 and -2. RESULTS: Seven (2.4%) of the subjects were co-infected with HTLV-2. One subject (among the seven co-infected with HTLV-2) was co-infected with HTLV-1 (0.3%). The only demographic factor significantly associated with HTLV-2 infection was history of intravenous drug abuse (p=0.002). CONCLUSIONS: While our results are limited to a single city, our low rates of co-infection do not support routine screening for HTLV-1/2 co-infection among HIV-infected individuals in the United States.
[Mh] MeSH terms primary: Coinfection/blood
HIV Infections/virology
HTLV-I Infections/virology
HTLV-II Infections/virology
[Mh] MeSH terms secundary: Coinfection/epidemiology
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Female
HIV Infections/complications
HIV Infections/epidemiology
HTLV-I Infections/complications
HTLV-I Infections/epidemiology
HTLV-II Infections/complications
HTLV-II Infections/epidemiology
Human T-lymphotropic virus 1/isolation & purification
Human T-lymphotropic virus 2/isolation & purification
Humans
Male
Middle Aged
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1705
[Cu] Class update date: 170515
[Lr] Last revision date:170515
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:160922
[St] Status:MEDLINE

  9 / 1237 MEDLINE  
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PubMed Central Full text
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[PMID]: 27529270
[Au] Autor:Usadi B; Bruhn R; Lin J; Lee TH; Blackburn E; Murphy EL
[Ad] Address:School of Public Health, University of California Berkeley, Berkeley, CA 94720-7360, USA. benusadi@gmail.com.
[Ti] Title:Telomere Length, Proviral Load and Neurologic Impairment in HTLV-1 and HTLV-2-Infected Subjects.
[So] Source:Viruses;8(8), 2016 Aug 11.
[Is] ISSN:1999-4915
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Short or damaged telomeres have been implicated in degenerative conditions. We hypothesized that analysis of telomere length (TL) in human T-cell lymphotropic virus (HTLV) infection and HTLV-associated neuropathy might provide clues to the etiology of HTLV-associated disease and viral dynamics. A subset of 45 human T-cell lymphotropic virus type 1 (HTLV-1), 45 human T-cell lymphotropic virus type 2 (HTLV-2), and 45 seronegative subjects was selected from the larger HTLV Outcomes Study (HOST) cohort, matched on age, sex and race/ethnicity. Telomere-to-single-copy gene (T/S) ratio (a measure of TL) and HTLV-1 and HTLV-2 proviral loads were measured in peripheral blood mononuclear cells (PBMCs) using quantitative PCR (qPCR). Vibration sensation measured by tuning fork during neurologic examinations performed as part of the HOST study allowed for an assessment of peripheral neuropathy. TL was compared between groups using t-tests, linear and logistic regression. Mean T/S ratio was 1.02 ± 0.16 in HTLV-1, 1.03 ± 0.17 in HTLV-2 and 0.99 ± 0.18 in HTLV seronegative subjects (p = 0.322). TL was not associated with HTLV-1 or -2 proviral load. Shorter TL was significantly associated with impaired vibration sense in the HTLV-2 positive group only. Overall, we found no evidence that telomere length was affected by chronic HTLV-1 and HTLV-2 infection. That TL was only associated with peripheral neuropathy in the HTLV-2-positive group is intriguing, but should be interpreted cautiously. Studies with larger sample size and telomere length measurement in lymphocyte subsets may clarify the relationship between TL and HTLV-infection.
[Mh] MeSH terms primary: HTLV-I Infections/pathology
HTLV-II Infections/pathology
Human T-lymphotropic virus 1/isolation & purification
Human T-lymphotropic virus 2/isolation & purification
Proviruses/isolation & purification
Telomere
Viral Load
[Mh] MeSH terms secundary: Adult
Aged
Aged, 80 and over
Female
HTLV-I Infections/virology
HTLV-II Infections/virology
Human T-lymphotropic virus 1/genetics
Human T-lymphotropic virus 2/genetics
Humans
Male
Middle Aged
Proviruses/genetics
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170926
[Lr] Last revision date:170926
[Js] Journal subset:IM
[Da] Date of entry for processing:160817
[St] Status:MEDLINE

  10 / 1237 MEDLINE  
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PubMed Central Full text
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[PMID]: 27519553
[Au] Autor:Enose-Akahata Y; Caruso B; Haner B; Charlip E; Nair G; Massoud R; Billioux BJ; Ohayon J; Switzer WM; Jacobson S
[Ad] Address:Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Building 10 Room 5C-103, Bethesda, MD, 20892, USA.
[Ti] Title:Development of neurologic diseases in a patient with primate T lymphotropic virus type 1 (PTLV-1).
[So] Source:Retrovirology;13(1):56, 2016 Aug 12.
[Is] ISSN:1742-4690
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Virus transmission from various wild and domestic animals contributes to an increased risk of emerging infectious diseases in human populations. HTLV-1 is a human retrovirus associated with acute T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 originated from ancient zoonotic transmission from nonhuman primates, although cases of zoonotic infections continue to occur. Similar to HTLV-1, the simian counterpart, STLV-1, causes chronic infection and leukemia and lymphoma in naturally infected monkeys, and combined are called primate T-lymphotropic viruses (PTLV-1). However, other clinical syndromes typically seen in humans such as a chronic progressive myelopathy have not been observed in nonhuman primates. Little is known about the development of neurologic and inflammatory diseases in human populations infected with STLV-1-like viruses following nonhuman primate exposure. RESULTS: We performed detailed laboratory analyses on an HTLV-1 seropositive patient with typical HAM/TSP who was born in Liberia and now resides in the United States. Using a novel droplet digital PCR for the detection of the HTLV-1 tax gene, the proviral load in PBMC and cerebrospinal fluid cells was 12.98 and 51.68 %, respectively; however, we observed a distinct difference in fluorescence amplitude of the positive droplet population suggesting possible mutations in proviral DNA. A complete PTLV-1 proviral genome was amplified from the patient's PBMC DNA using an overlapping PCR strategy. Phylogenetic analysis of the envelope and LTR sequences showed the virus was highly related to PTLV-1 from sooty mangabey monkeys (smm) and humans exposed via nonhuman primates in West Africa. CONCLUSIONS: These results demonstrate the patient is infected with a simian variant of PTLV-1, suggesting for the first time that PTLV-1smm infection in humans may be associated with a chronic progressive neurologic disease.
[Mh] MeSH terms primary: Deltaretrovirus Infections/complications
Deltaretrovirus Infections/virology
Paraparesis, Tropical Spastic/virology
Primate T-lymphotropic virus 1/isolation & purification
[Mh] MeSH terms secundary: Africa, Western
Aged
Animals
Deltaretrovirus Infections/transmission
Genes, pX
Haplorhini/virology
Humans
Leukocytes, Mononuclear/virology
Male
Phylogeny
Polymerase Chain Reaction
Primate T-lymphotropic virus 1/genetics
Primate T-lymphotropic virus 1/pathogenicity
Proviruses/genetics
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1705
[Cu] Class update date: 170512
[Lr] Last revision date:170512
[Js] Journal subset:IM
[Da] Date of entry for processing:160814
[St] Status:MEDLINE
[do] DOI:10.1186/s12977-016-0290-9


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