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| [PMID]: | 21351300 | | [Au] Autor: | Ko RK; Kim GO; Hyun CG; Jung DS; Lee NH |
| [Ad] Address: | Jeju Bio-Industry Development Center, Jeju Technopark, Ara-1, Jeju, Korea. | | [Ti] Title: | Compounds with tyrosinase inhibition, elastase inhibition and DPPH radical scavenging activities from the branches of Distylium racemosum Sieb. et Zucc. | | [So] Source: | Phytother Res;25(10):1451-6, 2011 Oct. | | [Is] ISSN: | 1099-1573 | | [Cp] Country of publication: | England | | [La] Language: | eng | | [Ab] Abstract: | Twenty compounds were isolated from the ethanol extract of Distylium racemosum branches and their inhibitory activities on tyrosinase, elastase and free radicals evaluated. The isolated compounds were identified as dibenzofurans (1-4), abscisic acid (5), 6'-O-galloylsalidroside (6), catechin derivatives (7-11), gallic acid derivatives (12-14), tyrosol (15), flavonoids (16-18), lupeol (19) and 1,2,3,6-tetragalloylglucose (20). For study of tyrosinase inhibition activities, when compared with arbutin (IC(50) 48.8 µg/mL), four compounds (8, 11, 13, 17) showed higher activities, with IC(50) values of 4.8, 30.2, 40.5 and 37.7 µg/mL, respectively. For the elastase inhibition test, dibenzofuran 1 showed greater activity than the positive control, oleanolic acid (IC(50) 9.7 µg/mL), with an IC(50) of 7.7 µg/mL. In the studies on DPPH radical scavenging activities, five compounds (11, 12, 13, 14, 15) showed higher activities than ascorbic acid (IC(50) 5.0 µg/mL), with IC(50) values of 4.6, 3.9, 2.9, 3.8 and 4.7 µg/mL, respectively. |
| [Mh] MeSH terms primary: |
Antioxidants/pharmacology Enzyme Inhibitors/pharmacology Free Radical Scavengers/pharmacology Hamamelidaceae/chemistry Monophenol Monooxygenase/antagonists & inhibitors Pancreatic Elastase/antagonists & inhibitors Plant Extracts/pharmacology
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| [Mh] MeSH terms secundary: |
Animals Antioxidants/isolation & purification Biphenyl Compounds/metabolism Enzyme Inhibitors/isolation & purification Free Radical Scavengers/isolation & purification Inhibitory Concentration 50 Picrates/metabolism Plant Extracts/isolation & purification Plant Stems Skin/enzymology Swine
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| [Pt] Publication type: | JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T | | [Nm] Name of substance: | 0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Enzyme Inhibitors); 0 (Free Radical Scavengers); 0 (Picrates); 0 (Plant Extracts); 1898-66-4 (2,2-diphenyl-1-picrylhydrazyl); EC 1.14.18.1 (Monophenol Monooxygenase); EC 3.4.21.36 (Pancreatic Elastase) | | [Em] Entry month: | 1203 | | [Js] Journal subset: | IM | | [Da] Date of entry for processing: | 110928 | | [St] Status: | MEDLINE |
| [do] DOI: | 10.1002/ptr.3439 |
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