Database : MEDLINE
Search on : Heart and Block [Words]
References found : 46514 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 4652 go to page                         

  1 / 46514 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 29524475
[Au] Autor:Vijayaraman P; Ellenbogen KA
[Ad] Address:Geisinger Heart Institute, Wilkes Barre, PA. Electronic address: pvijayaraman1@geisinger.edu.
[Ti] Title:Approach To Permanent His Bundle Pacing In Challenging Implants.
[So] Source:Heart Rhythm;, 2018 Mar 07.
[Is] ISSN:1556-3871
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  2 / 46514 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29522557
[Au] Autor:Li M; Chadda KR; Matthews GDK; Marr CM; Huang CL; Jeevaratnam K
[Ad] Address:Physiological Laboratory, University of Cambridge, Cambridge, United Kingdom.
[Ti] Title:Cardiac electrophysiological adaptations in the equine athlete-Restitution analysis of electrocardiographic features.
[So] Source:PLoS One;13(3):e0194008, 2018.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Exercising horses uniquely accommodate 7-8-fold increases in heart rate (HR). The present experiments for the first time analysed the related adaptations in action potential (AP) restitution properties recorded by in vivo telemetric electrocardiography from Thoroughbred horses. The horses were subjected to a period of acceleration from walk to canter. The QRS durations, and QT and TQ intervals yielded AP conduction velocities, AP durations (APDs) and diastolic intervals respectively. From these, indices of active, λ = QT/(QRS duration), and resting, λ0 = TQ/(QRS duration), AP wavelengths were calculated. Critical values of QT and TQ intervals, and of λ and λ0 at which plots of these respective pairs of functions showed unity slope, were obtained. These were reduced by 38.9±2.7% and 86.2±1.8%, and 34.1±3.3% and 85.9±1.2%, relative to their resting values respectively. The changes in λ were attributable to falls in QT interval rather than QRS duration. These findings both suggested large differences between the corresponding critical (129.1±10.8 or 117.4±5.6 bpm respectively) and baseline HRs (32.9±2.1 (n = 7) bpm). These restitution analyses thus separately identified concordant parameters whose adaptations ensure the wide range of HRs over which electrophysiological activation takes place in an absence of heart block or arrhythmias in equine hearts. Since the horse is amenable to this in vivo electrophysiological analysis and displays a unique wide range of heart rates, it could be a novel cardiac electrophysiology animal model for the study of sudden cardiac death in human athletes.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review
[do] DOI:10.1371/journal.pone.0194008

  3 / 46514 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29287886
[Au] Autor:Samdani S; Jain A; Meena V; Meena CB
[Ad] Address:Department of Otorhinolaryngology (ENT), Sawai Man Singh Medical College and Attached Group of Hospitals, Jaipur, Rajasthan, India.
[Ti] Title:Cardiac complications in diphtheria and predictors of outcomes.
[So] Source:Int J Pediatr Otorhinolaryngol;104:76-78, 2018 Jan.
[Is] ISSN:1872-8464
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To study the cardiac complications in diphtheria patients and to study the predictors of outcomes. STUDY DESIGN: Single centre prospective analysis of cardiac complications in diphtheria patients. RESULTS: In this study, there were 60 patients diagnosed with diphtheria with ECG changes. The ECG changes seen were sinus tachycardia (68.3%), T wave inversion (20%), ST segment depression (13.3%), right bundle branch block (5%), multiple atrial ectopics (3.3%). The case fatality rate in our study was 25% (15 patients). High CPK-MB, myoglobulin and cardiac troponin levels were associated with cardiac mortality. In our study, cardiac troponin T had the highest sensitivity (80%) and CK-MB had the highest specificity (95.56%). CONCLUSION: Cardiac involvement is a common complication of infection with C. diphtheria and is associated with high mortality. As diphtheria can be prevented by adequate vaccination, efforts should be maximized for high vaccine coverage with booster doses.
[Mh] MeSH terms primary: Diphtheria/complications
Heart Diseases/etiology
[Mh] MeSH terms secundary: Adolescent
Biomarkers
Child
Child, Preschool
Creatine Kinase
Electrocardiography
Female
Heart Diseases/epidemiology
Humans
Infant
Male
Prospective Studies
Sensitivity and Specificity
Troponin T
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Biomarkers); 0 (Troponin T); EC 2.7.3.2 (Creatine Kinase)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:171231
[St] Status:MEDLINE

  4 / 46514 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29203081
[Au] Autor:Reitan C; Chaudhry U; Atwater B; Jacobsson J; Couderc JP; Xia X; Carlson J; Platonov PG; Borgquist R
[Ad] Address:Department of Cardiology, Clinical Sciences, Lund University, Sweden. Electronic address: christian.reitan@med.lu.se.
[Ti] Title:Semi-automated QRS score as a predictor of survival in CRT treated patients with strict left bundle branch block.
[So] Source:J Electrocardiol;51(2):282-287, 2018 Mar - Apr.
[Is] ISSN:1532-8430
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Cardiac Resynchronization Therapy (CRT) is widely used for treating selected heart failure patients, but patients with myocardial scar respond worse to treatment. The Selvester QRS scoring system estimates myocardial scar burden using 12-lead ECG. This study's objective was to investigate the scores correlation to mortality in a CRT population. METHODS AND RESULTS: Data on consecutive CRT patients was collected. 401 patients with LBBB and available ECG data were included in the study. QuAReSS software was used to perform Selvester scoring. Mean Selvester score was 6.4, corresponding to 19% scar burden. The endpoint was death or heart transplant; outcome was analyzed using Cox proportional hazards models. A Selvester score >8 was significantly associated with higher risk of the combined endpoint (HR 1.59, p=.014, CI 1.09-2.3). CONCLUSION: Higher Selvester scores correlate to mortality in CRT patients with strict LBBB and might be of value in prognosticating survival.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Data-Review

  5 / 46514 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29174022
[Au] Autor:Sciarra L; Golia P; Palamà Z; Scarà A; De Ruvo E; Borrelli A; Martino AM; Minati M; Fagagnini A; Tota C; De Luca L; Grieco D; Delise P; Calò L
[Ad] Address:Cardiology Department, Policlinico Casilino, Rome, Italy.
[Ti] Title:Patients with left bundle branch block and left axis deviation show a specific left ventricular asynchrony pattern: Implications for left ventricular lead placement during CRT implantation.
[So] Source:J Electrocardiol;51(2):175-181, 2018 Mar - Apr.
[Is] ISSN:1532-8430
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Left bundle branch block (LBBB) and left axis deviation (LAD) patients may have poor response to resynchronization therapy (CRT). We sought to assess if LBBB and LAD patients show a specific pattern of mechanical asynchrony. METHODS: CRT candidates with non-ischemic cardiomyopathy and LBBB were categorized as having normal QRS axis (within -30° and +90°) or LAD (within -30° and -90°). Patients underwent tissue Doppler imaging (TDI) to measure time interval between onset of QRS complex and peak systolic velocity in ejection period (Q-peak) at basal segments of septal, inferior, lateral and anterior walls, as expression of local timing of mechanical activation. RESULTS: Thirty patients (mean age 70.6years; 19 males) were included. Mean left ventricular ejection fraction was 0.28±0.06. Mean QRS duration was 172.5±13.9ms. Fifteen patients showed LBBB with LAD (QRS duration 173±14; EF 0.27±0.06). The other 15 patients had LBBB with a normal QRS axis (QRS duration 172±14; EF 0.29±0.05). Among patients with LAD, Q-peak interval was significantly longer at the anterior wall in comparison to each other walls (septal 201±46ms, inferior 242±58ms, lateral 267±45ms, anterior 302±50ms; p<0.0001). Conversely, in patients without LAD Q-peak interval was longer at lateral wall, when compared to each other (septal 228±65ms, inferior 250±64ms, lateral 328±98ms, anterior 291±86ms; p<0.0001). CONCLUSIONS: Patients with heart failure, presenting LBBB and LAD, show a specific pattern of ventricular asynchrony, with latest activation at anterior wall. This finding could affect target vessel selection during CRT procedures in these patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Data-Review

  6 / 46514 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29520466
[Au] Autor:Tejman-Yarden S; Nof E; Beinart R; Ovadia N; Goldshmit Y; Buber J; Yonath H; Keizman E; Glikson M
[Ad] Address:The Edmond J. Safra International Congenital Heart Center, Sheba Medical Center, Ramat Gan, Israel. tegmanya@gmail.com.
[Ti] Title:Leadless Pacemaker Implantation in a Pediatric Patient with Prolonged Sinus Pauses.
[So] Source:Pediatr Cardiol;, 2018 Mar 08.
[Is] ISSN:1432-1971
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Permanent cardiac pacing is the only effective solution for patients with symptomatic bradycardia and heart block. About 10% of patients undergoing implantation of the conventional pacing system develop complications related to the subcutaneous pocket or the leads and in pediatric patients lead problems may rise in up to 30% of the patients. The leadless pacemaker devices were developed in order to minimize some of those complications. We present a case of an 11-year-old patient who presented after the sudden death of his older brother, with recurrent episodes of syncope and documented prolonged sinus pauses. The patient underwent percutaneous implantation of a leadless Micra™ pacemaker device with optimal results.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1007/s00246-018-1832-9

  7 / 46514 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29507883
[Au] Autor:Butera D; Passam F; Ju L; Cook KM; Woon H; Aponte-Santamaría C; Gardiner E; Davis AK; Murphy DA; Bronowska A; Luken BM; Baldauf C; Jackson S; Andrews R; Gräter F; Hogg PJ
[Ad] Address:The Centenary Institute, Newtown, New South Wales, Australia.
[Ti] Title:Autoregulation of von Willebrand factor function by a disulfide bond switch.
[So] Source:Sci Adv;4(2):eaaq1477, 2018 Feb.
[Is] ISSN:2375-2548
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Force-dependent binding of platelet glycoprotein Ib (GPIb) receptors to plasma von Willebrand factor (VWF) plays a key role in hemostasis and thrombosis. Previous studies have suggested that VWF activation requires force-induced exposure of the GPIb binding site in the A1 domain that is autoinhibited by the neighboring A2 domain. However, the biochemical basis of this "mechanopresentation" remains elusive. From a combination of protein chemical, biophysical, and functional studies, we find that the autoinhibition is controlled by the redox state of an unusual disulfide bond near the carboxyl terminus of the A2 domain that links adjacent cysteine residues to form an eight-membered ring. Only when the bond is cleaved does the A2 domain bind to the A1 domain and block platelet GPIb binding. Molecular dynamics simulations indicate that cleavage of the disulfide bond modifies the structure and molecular stresses of the A2 domain in a long-range allosteric manner, which provides a structural explanation for redox control of the autoinhibition. Significantly, the A2 disulfide bond is cleaved in ~75% of VWF subunits in healthy human donor plasma but in just ~25% of plasma VWF subunits from heart failure patients who have received extracorporeal membrane oxygenation support. This suggests that the majority of plasma VWF binding sites for platelet GPIb are autoinhibited in healthy donors but are mostly available in heart failure patients. These findings demonstrate that a disulfide bond switch regulates mechanopresentation of VWF.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review
[do] DOI:10.1126/sciadv.aaq1477

  8 / 46514 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29467248
[Au] Autor:Vite A; Zhang C; Yi R; Emms S; Radice GL
[Ad] Address:Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
[Ti] Title:α-Catenin-dependent cytoskeletal tension controls Yap activity in the heart.
[So] Source:Development;145(5), 2018 Mar 08.
[Is] ISSN:1477-9129
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Shortly after birth, muscle cells of the mammalian heart lose their ability to divide. At the same time, the N-cadherin/catenin cell adhesion complex accumulates at the cell termini, creating a specialized type of cell-cell contact called the intercalated disc (ICD). To investigate the relationship between ICD maturation and proliferation, αE-catenin ( ) and αT-catenin ( ) genes were deleted to generate cardiac-specific α-catenin double knockout (DKO) mice. DKO mice exhibited aberrant N-cadherin expression, mislocalized actomyosin activity and increased cardiomyocyte proliferation that was dependent on Yap activity. To assess effects on tension, cardiomyocytes were cultured on deformable polyacrylamide hydrogels of varying stiffness. When grown on a stiff substrate, DKO cardiomyocytes exhibited increased cell spreading, nuclear Yap and proliferation. A low dose of either a myosin or RhoA inhibitor was sufficient to block Yap accumulation in the nucleus. Finally, activation of RhoA was sufficient to increase nuclear Yap in wild-type cardiomyocytes. These data demonstrate that α-catenins regulate ICD maturation and actomyosin contractility, which, in turn, control Yap subcellular localization, thus providing an explanation for the loss of proliferative capacity in the newborn mammalian heart.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review

  9 / 46514 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29454139
[Au] Autor:Miller MA; Bhatt HV; Weiner M; Brouwer TF; Mittnacht AJ; Shariat A; Jeng C; Eden C; Lin HM; Salter B; Dukkipati SR; Reddy VY
[Ad] Address:Helmsley Electrophysiology Center in the Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, New York.
[Ti] Title:Implantation of the subcutaneous implantable cardioverter-defibrillator with truncal plane blocks.
[So] Source:Heart Rhythm;, 2018 Feb 14.
[Is] ISSN:1556-3871
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher

  10 / 46514 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 29215340
[Au] Autor:Yakut K; Erdogan I; Varan B; Atar I
[Ad] Address:Department of Pediatric Cardiology, Baskent University Ankara Hospital, Ankara, Turkey.
[Ti] Title:A Report of Brugada Syndrome Presenting with Cardiac Arrest Triggered by Verapamil Intoxication.
[So] Source:Balkan Med J;34(6):576-579, 2017 12 01.
[Is] ISSN:2146-3131
[Cp] Country of publication:Turkey
[La] Language:eng
[Ab] Abstract:BACKGROUND: Brugada syndrome is a disease characterized by a specific electrocardiographic pattern and an increased risk of sudden cardiac death. We present this case with the updated literature to emphasise the need to consider the diagnosis of Brugada syndrome in patients admitted to the emergency ward with sudden cardiac arrest. CASE REPORT: A 16-year-old female patient was admitted to the emergency ward with complaints of weakness and abdominal pain, and she had four cardiac arrests during her evaluation period. She was referred to our clinic for permanent pacemaker implantation. She was on a temporary pace maker after having had C-reactive protein. Her physical exam was normal except for bilaterally decreased lung sounds. Lung x-ray and computed tomography, which were performed by another institution, revealed minimal pleural effusion and nothing else of significance. Blood and peritoneal fluid samples were sterile. Echocardiographic exam and cardiac enzymes were also in the normal ranges. Electrocardiographic showed incomplete right branch block in leads V1 and V2. An ajmaline test revealed specific electrocardiographic findings of the type I Brugada pattern. We proposed implanting an implantable cardioverter defibrillator to the patient as there were positive findings on the ajmaline test as well as a history of sudden cardiac arrest. After this treatment proposal, the patient's family admitted that she had taken a high dose of verapamil and thus, the encountered bradycardia was associated with verapamil overuse. The ajmaline test was repeated as it was contemplated that the previous positive ajmaline test had been associated with verapamil overuse. Implantable cardioverter defibrillator implantation was proposed again as there was a history of sudden cardiac arrest; however, the family did not consent to implantable cardioverter defibrillator, and the patient was discharged and followed up. CONCLUSION: Brugada syndrome should be considered for patients who are admitted to the emergency ward with sudden cardiac arrest though surface electrocardiographic is normal. If there is a suspicion of Brugada syndrome, repeated electrocardiographic should be performed on different occasions. Diagnosis can be clarified by upper costal electrocardiographic or by administering Na channel blockers during electrocardiographic performance.
[Mh] MeSH terms primary: Anti-Arrhythmia Agents/poisoning
Brugada Syndrome/chemically induced
Heart Arrest/chemically induced
Verapamil/poisoning
[Mh] MeSH terms secundary: Adolescent
Ajmaline/pharmacology
Brugada Syndrome/diagnosis
Brugada Syndrome/physiopathology
Diagnosis, Differential
Electrocardiography
Female
Genetic Testing
Heart Arrest/physiopathology
Humans
Precipitating Factors
Sodium Channel Blockers/administration & dosage
Suicide, Attempted
Treatment Outcome
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Arrhythmia Agents); 0 (Sodium Channel Blockers); 1PON08459R (Ajmaline); CJ0O37KU29 (Verapamil)
[Em] Entry month:1801
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:171208
[St] Status:MEDLINE
[do] DOI:10.4274/balkanmedj.2016.1301


page 1 of 4652 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information