Database : MEDLINE
Search on : Hemiplegia [Words]
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[PMID]: 25937387
[Au] Autor:Patel R; Luat AF; Rajamani K
[Ad] Address:Pediatric Neurology Department, Children's Hospital of Michigan, Detroit, Michigan. Electronic address: drriddhu1734@gmail.com.
[Ti] Title:"Wrong Side" Tongue Deviation in Hemiplegia From Stroke.
[So] Source:Pediatr Neurol;53(1):95-6, 2015 Jul.
[Is] ISSN:1873-5150
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1506
[Js] Journal subset:IM
[St] Status:In-Data-Review

  2 / 11987 MEDLINE  
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[PMID]: 25476246
[Au] Autor:Shimakawa S; Nomura S; Ogino M; Fukui M; Kashiwagi M; Tanabe T; Tamai H
[Ad] Address:Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan. Electronic address: ZVQ10523@nifty.com....
[Ti] Title:ACTH therapy on intractable epilepsy in Hemiconvulsion-Hemiplegia-Epilepsy syndrome.
[So] Source:Brain Dev;37(7):733-7, 2015 Aug.
[Is] ISSN:1872-7131
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:INTRODUCTION: In the chronic phase of Hemiconvulsion-Hemiplegia-Epilepsy (HHE) syndrome, developing epilepsy may be intractable. Herein, we report a case where adrenocorticotropic hormone (ACTH) ceased an intractable habitual partial seizure in a patient with HHE syndrome. CASE REPORT: A developmentally normal one-year-old girl presented with left focal motor status epilepticus in the clinical course of rotavirus infection. She was diagnosed with HH syndrome. At 4 months after status epilepticus, she developed partial seizures that occurred daily, and which resulted in a stooped posture, head rotation to the right, and contraction of both upper limbs predominantly in the left arm. At this time, she was diagnosed with idiopathic HHE syndrome. Her seizures were not reduced by sodium valproate, clonazepam, clobazam, zonisamide, phenytoin, phenobarbital, topiramate, lamotrigine, or liposteroid. At the age of 7, ACTH therapy was performed. On the 10th day of ACTH therapy, the habitual seizure was ceased. However, partial seizures characterized by left arm contraction then developed. Treatment with 350mg/day lamotrigine prevented this emerging seizure. She has been free of both seizure types for more than one year, with no serious adverse effects of ACTH therapy. CONCLUSION: We suggest that ACTH therapy may be useful for patients with HHE, although further studies are required.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1506
[Js] Journal subset:IM
[St] Status:In-Data-Review

  3 / 11987 MEDLINE  
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[PMID]: 25754789
[Au] Autor:Tomhave WA; Van Heest AE; Bagley A; James MA
[Ad] Address:Shriners Hospital for Children-Twin Cities, Minneapolis, MN; Department of Orthopaedic Surgery, University of Minnesota, Minneapolis, MN; Motion Analysis Laboratory, Shriners Hospital for Children-Northern California, Sacramento, CA; Department of Orthopaedic Surgery, University of California, Davis...
[Ti] Title:Affected and contralateral hand strength and dexterity measures in children with hemiplegic cerebral palsy.
[So] Source:J Hand Surg Am;40(5):900-7, 2015 May.
[Is] ISSN:1531-6564
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To determine how the affected hemiplegic hand and contralateral dominant hand in children with hemiplegic cerebral palsy compare with age-matched norms for grip strength, pinch strength, and dexterity. METHODS: We enrolled 37 children with hemiplegic cerebral palsy (26 boys; average age, 9.8 y). Grip and pinch strength and Box and Blocks Test for dexterity were measured in both hands. Affected and contralateral hands results were analyzed and compared with each other and with norms for age and sex. RESULTS: Affected hands had significantly less grip and pinch strength than the contralateral hands. Subjects transported significantly fewer blocks in one minute with the Box and Blocks Test (mean, 10.8 blocks) with the affected hand than the contralateral hand. Compared with normative values, affected-side grip and pinch strengths were significantly less, whereas contralateral hand grip and pinch strengths were similar. Dexterity in both affected and contralateral hands was significantly less than normative values. Decreased dexterity in the contralateral hand was correlated with decreased nonverbal intelligence quotient. CONCLUSIONS: Dexterity of the contralateral hand is diminished in children with hemiplegia. Assessment of the contralateral hand may reveal opportunities for therapeutic intervention that improve fine motor function. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1504
[Js] Journal subset:IM
[St] Status:In-Process

  4 / 11987 MEDLINE  
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[PMID]: 26000382
[Au] Autor:Chen L; Qiu R; Li L; He D; Lv H; Wu X; Gu N
[Ti] Title:The role of exogenous neural stem cells transplantation in cerebral ischemic stroke.
[So] Source:J Biomed Nanotechnol;10(11):3219-30, 2014 Nov.
[Is] ISSN:1550-7033
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:To observe the effects of neural stem cells (NSCs) transplantation in rats' striatum and subventricular zone (SVZ) in rat models of focal cerebral ischemia and reperfusion. Hippocampus was extracted from fetal rats with 14 days of gestation. Suspension culture was used to isolate and culture the rat's NSCs. A cerebral ischemia and reperfusion rat's model was made on the left side of the brain through occlusion of the left middle cerebral artery. Neurological signs were assessed by Zea Longa's five-grade scale, with scores 1, 2, and 3 used to determine the successful establishment of the rat's model. The NSCs were stereotaxically injected into the left striatum 24 hours after the successful rat's model was built. Rats were then randomly divided into 5 groups, namely, normal group, sham operation group, ischemia group, PBS transplantation group, and NSCs transplantation group, each of which was observed on day 3, day 7, and day 14. The ischemia-related neurological deficits were assessed by using a 7-point evaluation criterion. Forelimb injuries were evaluated in all rats using the foot-fault approach. Infarct size changes were observed through TTC staining and cell morphology and structure in the infarct region were investigated by Nissl staining. Apoptosis and apoptosis-positive cell counts were studied by Tunel assay. Expressions of double-labeling positive cells in the striatum and subventricular zone (SVZ) were observed by BrdU/NeuN and BrdU/GFAP fluorescent double-labeling method and the number of positive cells in the striatum and SVZ was counted. Results from the differently treated groups showed that right hemiplegia occurred in the ischemia group, PBS transplantation group, and NSCs transplantation group in varying degrees. Compared with the former two groups, there was least hemiplegia in the NSCs transplantation group. The TTC staining assay showed that rats in the NSCs transplantation group had smaller infarct volume than those from the PBS transplantation group. The Nissl dyeing showed that there was a large area of neuronal necrosis and apoptosis in the ischemia and PBS transplantation groups, and damage was mainly focused in the striatum. Degeneration and damage of nerve cells were significantly reduced in the NSCs transplantation group. The Tunel assay showed that the number of apoptosis-positive cells in the NSCs transplantation group was less than that in the PBS transplantation group at each time point. Double immunofluorescent labeling showed that the proliferation of endogenous neural stem cells began at the third day, reaching the peak at the 7th day, and was significantly reduced at the 14th day in the SVZ. The number of BrdU/NeuN increased significantly in the NSCs transplantation group compared to that in the PBS transplantation group (P < 0.05). The number of BrdU/GFAP decreased significantly in the NSCs transplantation group compared to that of PBS transplantation group (P < 0.05). The number of BrdU/GFAP-positive cells in the striatum was observed to be much more in the PBS transplantation group than in the NSCs transplantation group. Both neurological deficits and coordination capacity of rats with cerebral ischemia were significantly improved via transplantation of the neural stem cells. In conclusion, transplantation of neural stem cells can therefore possibly promote the differentiation of endogenous NSCs into neurons and reduce their differentiation towards glial cells. Transplantation of the neural stem cells may also change the ischemic microenvironment of striatum, possibly inhibiting the proliferation of glial cells.
[Mh] MeSH terms primary: Brain Ischemia/pathology
Brain Ischemia/therapy
Neural Stem Cells/transplantation
Stroke/pathology
Stroke/therapy
[Mh] MeSH terms secundary: Animals
Brain Ischemia/complications
Rats
Rats, Sprague-Dawley
Stroke/etiology
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1506
[Js] Journal subset:IM
[Da] Date of entry for processing:150522
[St] Status:MEDLINE

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[PMID]: 25697143
[Au] Autor:Zeng L; Wang L; Ye F; Chen J; Lei T; Chen J
[Ad] Address:Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
[Ti] Title:Clinical characteristics of patients with asymptomatic intracranial meningiomas and results of their surgical management.
[So] Source:Neurosurg Rev;38(3):481-8, 2015 Jul.
[Is] ISSN:1437-2320
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Surgery performed during the asymptomatic phase of meningioma remains controversial. The effects of surgery and the factors associated with postsurgical complications and patient prognosis were studied to optimize surgical decisions for clinicians who treat asymptomatic patients. The medical records of 513 patients with meningiomas (112 patients were asymptomatic) treated at our hospital from May 2007 to April 2012 were retrospectively reviewed. The results were analyzed with univariate and multivariate analyses. Asymptomatic meningiomas were characterized by a more common cerebral hemispheric location, a smaller size, and a lack of peritumoral edema. A significantly higher Simpson I resection rate of 95.2 % was achieved in tumors located in the cerebral hemisphere; in contrast, a rate of 66.7 % was obtained in tumors located at the skull base (P = 0.003). The overall postsurgical complication rate was 13.6 %, which was lower than the rate of 21.7 % in the symptomatic patients. Hemiplegia was the most common complication, which occurred most often in the patients with tumors in parietal locations (P = 0.015). Ninety-two percent of the asymptomatic patients achieved a Glasgow Outcome Scale (GOS) score of 5 1 year after the operation, and significantly more patients younger than 60 years of age obtained a GOS score of 5 compared with patients older than 60 years of age (P = 0.006). To achieve maximal tumor resection and good patient recovery, tumor location and patient age should be carefully considered prior to choosing to perform surgery in asymptomatic patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1506
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s10143-015-0619-1

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[PMID]: 26082417
[Au] Autor:Li CH; Hsu YC; Hsu YC
[Ad] Address:Division of Neurology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, Taiwan.
[Ti] Title:Left Mandibular Pain in a Patient of Aortic Dissection Presenting with Acute Ischemic Stroke: a Case Report.
[So] Source:Acta Neurol Taiwan;23(4):129-33, 2014 Dec.
[Is] ISSN:1028-768X
[Cp] Country of publication:China (Republic : 1949- )
[La] Language:eng
[Ab] Abstract:PURPOSE: If a patient with aortic dissection (AoD) is inadvertently treated with thrombolytic agents, severe complications and poor outcomes are likely to ensue. We reported a case and postulated mandibular pain as warning sign for diagnosing AoD related stroke. CASE REPORT: We report an 81-year-old woman presenting with left mandibular pain followed by left hemiplegia. Extracranial carotid duplex showed dissection of the right common carotid artery and chest CT angiography proved AoD. She did not have any typical chest or back pain. CONCLUSION: AoD should be carefully considered in patients with acute ischemic stroke presenting with mandibular pain. A high clinical alert and urgent CT angiography may help identify AoD.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1506
[Js] Journal subset:IM
[St] Status:In-Data-Review

  7 / 11987 MEDLINE  
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[PMID]: 25566688
[Au] Autor:Wesemann T; Nüllmann H; Pflug MA; Heppner HJ; Pientka L; Thiem U
[Ad] Address:Department of Geriatrics, Marienhospital Herne, University of Bochum, Widumer Str. 8, D-44627, Herne, Germany. thomas.wesemann@rub.de....
[Ti] Title:Pneumonia severity, comorbidity and 1-year mortality in predominantly older adults with community-acquired pneumonia: a cohort study.
[So] Source:BMC Infect Dis;15:2, 2015.
[Is] ISSN:1471-2334
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: In patients with community-acquired pneumonia (CAP), short-term mortality is largely dependent on pneumonia severity, whereas long-term mortality is considered to depend on comorbidity. However, evidence indicates that severity scores used to assist management decisions at disease onset may also be associated with long-term mortality. Therefore, the objective of the study was to investigate the performance of the pneumonia severity scores CURB-65 and CRB-65 compared to the Charlson Comorbidity Index (CCI) for predicting 1-year mortality in adults discharged from hospital after inpatient treatment for CAP. METHODS: From a single centre, all cases of patients with CAP treated consecutively as inpatients between 2005 and 2009 and surviving at least 30 days after admission were analysed. The patients' vital status was obtained from the relevant local register office. CURB-65, CRB-65 and CCI were compared using receiver operating characteristics (ROC) analysis. RESULTS: Of 498 cases analysed, 106 (21.3%) patients died within 1 year. In univariate analysis, age ≥65 years, nursing home residency, hemiplegia, dementia and congestive heart failure were significantly associated with mortality. CURB-65, CRB-65 and CCI were also all associated with mortality at 1 year. ROC analysis yielded a weak, yet comparable test performance for CURB-65 (AUC and corresponding 95% confidence interval [CI] for risk categories: 0.652 [0.598-0.706]) and CCI (AUC [CI]: 0.631 [0.575-0.688]; for CRB-65 0.621 [0.565-0.677] and 0.590 [0.533-0.646]). CONCLUSIONS: Neither CURB-65 or CRB-65 nor CCI allow excellent discrimination in terms of predicting longer term mortality. However, CURB-65 is significantly associated with long-term mortality and performed equally to the CCI in this respect. This fact may help to identify CAP survivors at higher risk after discharge from hospital.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Cu] Class update date: 150423
[Lr] Last revision date:150423
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1186/s12879-014-0730-x

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[PMID]: 25142215
[Au] Autor:Moro V; Scandola M; Bulgarelli C; Avesani R; Fotopoulou A
[Ad] Address:a Department of Philosophy, Education and Psychology , University of Verona , Verona , Italy.
[Ti] Title:Error-based training and emergent awareness in anosognosia for hemiplegia.
[So] Source:Neuropsychol Rehabil;25(4):593-616, 2015 Aug.
[Is] ISSN:1464-0694
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Residual forms of awareness have recently been demonstrated in subjects affected by anosognosia for hemiplegia, but their potential effects in recovery of awareness remain to date unexplored. Emergent awareness refers to a specific facet of motor unawareness in which anosognosic subjects recognise their motor deficits only when they have been requested to perform an action and they realise their errors. Four participants in the chronic phase after a stroke with anosognosia for hemiplegia were recruited. They took part in an "error-full" or "analysis of error-based" rehabilitative training programme. They were asked to attempt to execute specific actions, analyse their own strategies and errors and discuss the reasons for their failures. Pre- and post-training and follow-up assessments showed that motor unawareness improved in all four patients. These results indicate that unsuccessful action attempts with concomitant error analysis may facilitate the recovery of emergent awareness and, sometimes, of more general aspects of awareness.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1506
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1080/09602011.2014.951659

  9 / 11987 MEDLINE  
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[PMID]: 25809299
[Au] Autor:Scharf M; Miske R; Heidenreich F; Giess R; Landwehr P; Blöcker IM; Begemann N; Denno Y; Tiede S; Dähnrich C; Schlumberger W; Unger M; Teegen B; Stöcker W; Probst C; Komorowski L
[Ad] Address:From the Institute of Experimental Immunology (M.S., R.M., I.-M.B., N.B., Y.D., S.T., C.D., W. Schlumberger, M.U., B.T., W. Stöcker, C.P., L.K.), EUROIMMUN AG, Lübeck; and Departments of Neurology and Clinical Neurophysiology (F.H., R.G.) and Diagnostic and Interventional Radiology (P.L.), Hospital ...
[Ti] Title:Neuronal Na+/K+ ATPase is an autoantibody target in paraneoplastic neurologic syndrome.
[So] Source:Neurology;84(16):1673-9, 2015 Apr 21.
[Is] ISSN:1526-632X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVES: To identify an autoreactivity in a 66-year-old woman who presented with combined brainstem and cerebellar syndrome including vertical gaze palsy, severe progressive ataxia, and spastic tetraparesis, an acute deterioration of vision, dysarthria, and dysphagia with concurrent diagnosis of a colon adenocarcinoma. METHODS: Patient's serum and CSF underwent comprehensive autoantibody screening by indirect immunofluorescence assay and immunoblot. For autoantigen purification, a histo-immunoprecipitation technique was developed followed by mass spectrometrical analysis. Recombinant candidate antigens were expressed in HEK293 and used to verify the identification. RESULTS: Indirect immunofluorescence assay screening revealed strong immunoglobulin G reactivity with neural tissues in serum and CSF, but not with a panel of 28 recombinantly expressed established neural autoantigens. The hitherto unknown target antigen was identified as the neuronal Na(+)/K(+) ATPase. Epitope mapping and competitive inhibition experiments showed that the autoantibodies were directed against the membrane-spanning alpha 3 subunit (ATP1A3) of the enzyme but did not bind to extracellular epitopes. Immunohistochemical analysis revealed overexpression of this subunit in the patient's tumor. CONCLUSIONS: We describe a case of an anti-ATP1A3-associated neurologic disorder. Mutations in the gene encoding this neuronal surface protein have already been recognized as the cause of infantile alternating hemiplegia, rapid-onset dystonia parkinsonism, and CAPOS syndrome. Although the autoantibodies are unlikely to be pathogenic, they are likely to be rare biomarkers for the apparently paraneoplastic neurologic syndrome or for the tumor itself.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1504
[Js] Journal subset:AIM; IM
[St] Status:In-Process
[do] DOI:10.1212/WNL.0000000000001493

  10 / 11987 MEDLINE  
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[PMID]: 25770065
[Au] Autor:McCarrel TM; Woodie JB
[Ad] Address:Large Animal Clinical Sciences, University of Florida College of Veterinary Medicine, PO Box 100136, Gainesville, Florida 32610, USA.
[Ti] Title:Update on laryngeal disorders and treatment.
[So] Source:Vet Clin North Am Equine Pract;31(1):13-26, 2015 Apr.
[Is] ISSN:1558-4224
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Laryngeal disorders are relatively common in the horse, and thorough diagnostic evaluation is essential to make an accurate definitive diagnosis and selection of appropriate treatment. The value of exercising endoscopy must not be overlooked, and the recent development of dynamic (overground) endoscopy is providing new insights into dynamic laryngeal lesions. The focus of this article will be on recently described disorders and treatments or modifications to existing treatments. It summarizes the numerous investigations attempting to perfect the laryngoplasty procedure for treatment of laryngeal hemiplegia. The newly described conditions, bilateral dynamic laryngeal collapse, and dynamically flaccid epiglottis will also be discussed.
[Mh] MeSH terms primary: Horse Diseases/diagnosis
Horse Diseases/therapy
Laryngeal Diseases/veterinary
[Mh] MeSH terms secundary: Animals
Endoscopy/veterinary
Horse Diseases/surgery
Horses
Laryngeal Diseases/diagnosis
Laryngeal Diseases/surgery
Laryngeal Diseases/therapy
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1506
[Js] Journal subset:IM
[Da] Date of entry for processing:150315
[St] Status:MEDLINE


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