Database : MEDLINE
Search on : Hemiplegia [Words]
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[PMID]: 25049388
[Au] Autor:Stangenberg L; Burzyn D; Binstadt BA; Weissleder R; Mahmood U; Benoist C; Mathis D
[Ad] Address:Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114; and....
[Ti] Title:Denervation protects limbs from inflammatory arthritis via an impact on the microvasculature.
[So] Source:Proc Natl Acad Sci U S A;111(31):11419-24, 2014 Aug 5.
[Is] ISSN:1091-6490
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Two-way communication between the mammalian nervous and immune systems is increasingly recognized and appreciated. An intriguing example of such crosstalk comes from clinical observations dating from the 1930s: Patients who suffer a stroke and then develop rheumatoid arthritis atypically present with arthritis on only one side, the one not afflicted with paralysis. Here we successfully modeled hemiplegia-induced protection from arthritis using the K/BxN serum-transfer system, focused on the effector phase of inflammatory arthritis. Experiments entailing pharmacological inhibitors, genetically deficient mouse strains, and global transcriptome analyses failed to associate the protective effect with a single nerve quality (i.e., with the sympathetic, parasympathetic, or sensory nerves). Instead, there was clear evidence that denervation had a long-term effect on the limb microvasculature: The rapid and joint-localized vascular leak that typically accompanies and promotes serum-transferred arthritis was compromised in denervated limbs. This defect was reflected in the transcriptome of endothelial cells, the expression of several genes impacting vascular leakage or transendothelial cell transmigration being altered in denervated limbs. These findings highlight a previously unappreciated pathway to dissect and eventually target in inflammatory arthritis.
[Mh] MeSH terms primary: Arthritis, Experimental/complications
Arthritis, Experimental/prevention & control
Denervation
Hindlimb/blood supply
Hindlimb/innervation
Inflammation/complications
Microvessels/pathology
[Mh] MeSH terms secundary: Animals
Ankle/blood supply
Ankle/pathology
Arthritis, Experimental/pathology
Disease Models, Animal
Hindlimb/pathology
Inflammation/pathology
Male
Mice
Mice, Inbred C57BL
Paralysis/complications
Paralysis/pathology
Serum/metabolism
Transcriptome/genetics
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1410
[Js] Journal subset:IM
[Da] Date of entry for processing:140806
[St] Status:MEDLINE
[do] DOI:10.1073/pnas.1410854111

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[PMID]: 24448876
[Au] Autor:Vincent-Onabajo GO; Hamzat TK; Owolabi MO
[Ad] Address:Department of Medical Rehabilitation (Physiotherapy), University of Maiduguri, Maiduguri, Borno State, Nigeria.
[Ti] Title:Are there gender differences in longitudinal patterns of functioning in Nigerian stroke survivors during the first year after stroke?
[So] Source:NeuroRehabilitation;34(2):297-304, 2014.
[Is] ISSN:1878-6448
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: Several studies have examined gender differences in various stroke outcomes. There is however little information on the influence of gender on post-stroke functioning in the context of the International Classification of Functioning, Disability and Health (ICF). OBJECTIVE: Gender differences in selected components of functioning, namely motor performance (body function), activity and participation, were examined in a sample of Nigerian stroke survivors. METHODS: This longitudinal study involved consenting first-incidence stroke survivors who were consecutively recruited from in-patient wards of a University teaching hospital in northern Nigeria. Demographic and clinical data were obtained at recruitment while motor performance, activity and participation were assessed at the 1st, 3rd, 6th, 9th and 12th months using the Simplified Fugl Meyer scale, the Functional Independence Measure Motor Sub-scale and the London Handicap Scale respectively. RESULTS: Participants were thirty-three male (60%) and 22 female (40%) stroke survivors who did not significantly differ in age, stroke sub-type, laterality and initial severity (P > 0.05). There were also no significant differences in motor performance, activity and participation between the male and female stroke survivors across the time points. CONCLUSION: Gender differences were not observed in the components of functioning over the first 12 months post-stroke.
[Mh] MeSH terms primary: Motor Activity/physiology
Sex Factors
Stroke/rehabilitation
[Mh] MeSH terms secundary: Activities of Daily Living
Adult
Aged
Cultural Characteristics
Female
Hemiplegia/physiopathology
Hemiplegia/rehabilitation
Humans
Longitudinal Studies
Male
Middle Aged
Nigeria
Quality of Life
Recovery of Function
Stroke/physiopathology
Survivors
Time Factors
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1410
[Js] Journal subset:IM
[Da] Date of entry for processing:140425
[St] Status:MEDLINE
[do] DOI:10.3233/NRE-141047

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[PMID]: 24419019
[Au] Autor:Kojima K; Ikuno K; Morii Y; Tokuhisa K; Morimoto S; Shomoto K
[Ad] Address:Department of Rehabilitation Medicine, Nishiyamato Rehabilitation Hospital, Nara, Japan Graduate School of Health Science, Kio University, Nara, Japan....
[Ti] Title:Feasibility study of a combined treatment of electromyography-triggered neuromuscular stimulation and mirror therapy in stroke patients: a randomized crossover trial.
[So] Source:NeuroRehabilitation;34(2):235-44, 2014.
[Is] ISSN:1878-6448
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: Mirror therapy (MT) and electromyography-triggered neuromuscular stimulation (ETMS) are both effective treatments for impaired upper limbs following stroke. A combination of these two treatments (ETMS-MT) may result in greater gain than either treatment alone. OBJECTIVES: The feasibility and possible effects of ETMS-MT upon upper extremity function were investigated in stroke patients. METHODS: Thirteen post-acute stroke patients were randomly assigned to an immediate ETMS-MT group or a delayed ETMS-MT group and then underwent an 8-week training program. The immediate ETMS-MT group received ETMS-MT in addition to physical and occupational therapy (PT+OT) for 4 weeks. They then received only PT+OT for the next 4 weeks. In the delayed ETMS-MT group, interventions were provided in the reverse order. The main outcome measure was the Fugl-Meyer Assessment (FMA). RESULTS: The immediate ETMS-MT group showed significantly greater gain in FMA in the first 4 weeks. The delayed ETMS-MT group showed significantly greater gain in active range of motion during the latter 4 weeks. No adverse effects were reported following ETMS-MT. CONCLUSION: ETMS-MT might be as effective as independent MT or ETMS without causing any side effects. Future research should focus upon the direct comparisons between independent and combined interventions.
[Mh] MeSH terms primary: Electric Stimulation Therapy/methods
Electromyography/methods
Functional Laterality/physiology
Hemiplegia/rehabilitation
Stroke/rehabilitation
Upper Extremity
[Mh] MeSH terms secundary: Adult
Aged
Combined Modality Therapy/methods
Cross-Over Studies
Feasibility Studies
Female
Hemiplegia/etiology
Humans
Male
Middle Aged
Outcome Assessment (Health Care)
Physical Therapy Modalities
Pilot Projects
Range of Motion, Articular/physiology
Recovery of Function
Stroke/complications
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Entry month:1410
[Js] Journal subset:IM
[Da] Date of entry for processing:140425
[St] Status:MEDLINE
[do] DOI:10.3233/NRE-131038

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[PMID]: 24419017
[Au] Autor:Manigandan JB; Ganesh GS; Pattnaik M; Mohanty P
[Ad] Address:Swami Vivekanand National Institute of Rehabilitation Training & Research, Cuttack Dt, Odisha, India....
[Ti] Title:Effect of electrical stimulation to long head of biceps in reducing gleno humeral subluxation after stroke.
[So] Source:NeuroRehabilitation;34(2):245-52, 2014.
[Is] ISSN:1878-6448
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: Glenohumeral subluxation is the most frequent complication in post stroke hemiplegia and its reduction has been considered an important goal. Though it has been demonstrated that cyclical electrical stimulation of posterior deltoid and supraspinatus muscles can reduce subluxation, the role of biceps has not been given due consideration. OBJECTIVE: The purpose of this study was to determine whether electrical stimulation to the long head of biceps could more effectively reduce gleno humeral subluxation. METHODS: 24 patients were selected and consecutively assigned to group 1 (electrical stimulation to supraspinatus & posterior deltoid) and group II (electrical stimulation to supraspinatus, posterior deltoid & long head of the biceps) along with routine physiotherapy and occupational therapy for a period of 5 weeks. All patients were assessed for shoulder subluxation, pain and shoulder active abduction range of motion at the time of recruitment to study and after 5 weeks of therapy. RESULTS: Both the groups showed significant improvement in parameters measured. Tukey's post hoc analysis showed the results were more significant in Group II. CONCLUSIONS: Electrical stimulation to biceps along with the supraspinatus and posterior deltoid can more effectively reduce shoulder subluxation.
[Mh] MeSH terms primary: Electric Stimulation Therapy/methods
Muscle, Skeletal/physiology
Shoulder Dislocation/prevention & control
Stroke/complications
[Mh] MeSH terms secundary: Adult
Aged
Female
Hemiplegia/etiology
Humans
Humerus
Male
Middle Aged
Range of Motion, Articular
Shoulder Dislocation/etiology
Shoulder Pain/etiology
Shoulder Pain/prevention & control
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Entry month:1410
[Js] Journal subset:IM
[Da] Date of entry for processing:140425
[St] Status:MEDLINE
[do] DOI:10.3233/NRE-131041

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[PMID]: 24401828
[Au] Autor:Yaliman A; Kesiktas N; Ozkaya M; Eskiyurt N; Erkan O; Yilmaz E
[Ad] Address:Physical Medicine and Rehabilitation Department, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey....
[Ti] Title:Evaluation of intrarater and interrater reliability of the Wisconsin Gait Scale with using the video taped stroke patients in a Turkish sample.
[So] Source:NeuroRehabilitation;34(2):253-8, 2014.
[Is] ISSN:1878-6448
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To establish the intrarater and interrater reliability of Wisconsin Gait Scale (WGS) in hemiplegic patients. DESIGN: Repeated-measures reliability study using video data of stroke patients. SETTING: Rehabilitation department of the university hospital. PARTICIPITANTS: Nineteen hemiplegic patients with 3-9 months stroke history and two physiatrists and two physical therapists. INTERVENTIONS: Video recordings were assessed twice, at an interval of 2 days, by the two physiatrists and two physical therapists. MAIN OUTCOME MEASURE: Wisconsin Gait Scale. RESULTS: Internal consistency coefficients for the WGS were excellent; Cronbach scores were 0.91 and 0.94 for the first and third days. Coefficient of Repeatability (CR) for observers' WGS assessments were ranged between 4.23-5.76 and intraclass correlation coefficients for total WGS score were indicated very high interrater reliability at the begining and end, respectively 0.91 and 0.96. Intraclass correlation coefficients for fourteen items of WGS ranged from 0.81 to 1. "Hip hiking at mid-swing", "Circumduction at mid-swing" and "Hip extension of the affected leg" were the items with lowest correlation coefficients. Intrarater reliability for total WGS scores ranged from 0.75 to 0.90. CONCLUSION: WGS was found excellent in reliability and may provide an objective means to document the findings from observational gait analysis, which is frequently used in clinical practice by rehabilitation teams.
[Mh] MeSH terms primary: Gait Disorders, Neurologic/rehabilitation
Hemiplegia/rehabilitation
Stroke/rehabilitation
Videotape Recording
[Mh] MeSH terms secundary: Adult
Aged
Female
Humans
Male
Middle Aged
Observer Variation
Outcome Assessment (Health Care)
Postural Balance
Reproducibility of Results
Time Factors
Turkey
Young Adult
[Pt] Publication type:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Entry month:1410
[Js] Journal subset:IM
[Da] Date of entry for processing:140425
[St] Status:MEDLINE
[do] DOI:10.3233/NRE-131033

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[PMID]: 25269055
[Au] Autor:Zhang C; Feng F; Zhu Y; Wang R; Xing B
[Ad] Address:Peking Union Medical College Hospital, Departments of Neurosurgery, Beijing, China.
[Ti] Title:Cerebral infarction caused by pituitary apoplexy: case report and review of literature.
[So] Source:Turk Neurosurg;24(5):782-7, 2014.
[Is] ISSN:1019-5149
[Cp] Country of publication:Turkey
[La] Language:eng
[Ab] Abstract:Pituitary apoplexy followed by cerebral infarction is rare. In this report, we present a 42-year-old man who had been diagnosed of pituitary adenoma presented with a sudden onset of unconsciousness, left hemiplegia and right ptosis. Investigations revealed the development of pituitary apoplexy. The extension of tumor mass compressed the supraclinoid portion of the right internal carotid artery, resulting in the cerebral infarction in the right anterior and middle cerebral artery territory. Left anterior cerebral artery territory infarction was also found, which could be caused by vasospasm provoked by pituitary apoplexy. The patient underwent decompression surgery via transsphenoidal approach after four weeks' conservative treatment, and pathological examination revealed hemorrhage and necrosis of the pituitary adenoma. His symptoms improved within five months' follow-up. Since pituitary apoplexy producing cerebral infarction is rare, clinicians should be alert to that possibility, and delayed transsphenoidal surgery following conservative management with steroids is the appropriate management of such an occurrence.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1410
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.5137/1019-5149.JTN.9237-13.0

  7 / 11744 MEDLINE  
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[PMID]: 25084148
[Au] Autor:Nishijima T; Gatanaga H; Teruya K; Tajima T; Kikuchi Y; Hasuo K; Oka S
[Ad] Address:1 AIDS Clinical Center, National Center for Global Health and Medicine , Tokyo, Japan .
[Ti] Title:Brain Magnetic Resonance Imaging Screening Is Not Useful for HIV-1-Infected Patients Without Neurological Symptoms.
[So] Source:AIDS Res Hum Retroviruses;30(10):970-4, 2014 Oct.
[Is] ISSN:1931-8405
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Abstract We investigated the diagnostic usefulness of brain magnetic resonance imaging (MRI) screening in HIV-1-infected patients without neurological symptoms in detecting intracranial diseases at early stages. In this retrospective analysis, the study patients were HIV-1-infected patients who underwent brain MRI scan in clinical practice between 2001 and 2013. We excluded patients with MRI for (1) follow-up examination for prediagnosed intracranial diseases, (2) cancer staging, (3) screening mycobacterium/bacteria/fungi disease proliferation in the brain, and (4) evaluation for meningitis/encephalitis. The study patients (n=485) were classified into two groups: those who underwent brain MRI scan without any neurological symptoms/signs (asymptomatic patients, n=158) and those who underwent MRI due to such symptoms (symptomatic patients, n=327). Asymptomatic patients had lower CD4 counts than symptomatic patients (median 78 versus 241/µl). Intracranial diseases were detected in three (2%) of the asymptomatic patients [two toxoplasmosis and one progressive multifocal leukoencephalopathy (PML)] compared to 58 (19%) of the symptomatic patients (the χ(2) test, p<0.01). The latter included toxoplasmosis (n=10), PML (n=7), cytomegalovirus encephalitis (n=3), primary central nervous system lymphoma (n=3), cryptococcoma/meningitis (n=3), and HIV-associated dementia (n=17). Among symptomatic patients, intracranial diseases were common in those with slurred speech (3/6, 50%), seizure (4/10, 40%), eyesight/vision abnormality (5/16, 31%), altered mental status (8/31, 26%), and hemiplegia/numbness (13/50, 26%). For patients with CD4 count <200/µl, intracranial diseases were detected in only 3 (3%) of 144 asymptomatic patients, compared with 46 (32%) of 113 symptomatic patients (p<0.01). Brain MRI screening for HIV-1-infected patients without neurological symptoms is of little value.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1410
[Js] Journal subset:IM; X
[St] Status:In-Data-Review
[do] DOI:10.1089/AID.2014.0123

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[PMID]: 25266619
[Au] Autor:García-Baró-Huarte M; Iglesias-Mohedano AM; Slöcker-Barrio M; Vázquez-López M; García-Morín M; Miranda-Herrero MC; Castro-Castro P
[Ad] Address:Department of Paediatrics, Hospital General Universitario Gregorio Marañón, Madrid, Spain. Electronic address: mariagbaro@gmail.com....
[Ti] Title:Phenotypic Variability in a Four Generation Family With a p.Thr666Met CACNA1A Gene Mutation.
[So] Source:Pediatr Neurol;51(4):557-9, 2014 Oct.
[Is] ISSN:1873-5150
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Familial hemiplegic migraine type 1, episodic ataxia type 2, and spinocerebellar ataxia type 6 are distinct neurological disorders associated with mutations in the CACNA1A gene. Phenotypic variability and clinical overlap are recognized. PATIENTS: We describe a 2-year-old child with transiently decreased consciousness and clinical and radiological signs of early-onset cerebellar atrophy. The family history was significant, and 11 affected members across four generations indicated an unusually wide clinical spectrum including migraine, hemiplegia, coma, and progressive cerebellar ataxia. RESULTS: The p.Thr666Met mutation of the CACNA1A gene was identified in the index patient and in five of his affected relatives who were analyzed. Our patient is the youngest one of this entity diagnosed to date. CONCLUSIONS: Taking into account such a wide clinical expression of these gene mutations, it could be more accurate to speak about "channel-related diseases" to characterize the clinical expression according to the genetic analysis and to the phenotypes associated with each CACNA1A gene mutation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

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[PMID]: 25062271
[Au] Autor:Spitz MA; Dubois-Teklali F; Vercueil L; Sabourdy C; Nugues F; Vincent A; Oliver V; Bulteau C
[Ad] Address:Service de Pédiatrie 1, CHRU Hautepierre, Strasbourg, France....
[Ti] Title:Voltage-gated potassium channels autoantibodies in a child with rasmussen encephalitis.
[So] Source:Neuropediatrics;45(5):336-40, 2014 Oct.
[Is] ISSN:1439-1899
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Rasmussen encephalitis (RE) is a severe epileptic and inflammatory encephalopathy of unknown etiology, responsible for focal neurological signs and cognitive decline. The current leading hypothesis suggests a sequence of immune reactions induced by an indeterminate factor. This sequence is thought to be responsible for the production of autoantibody-mediated central nervous system degeneration. However, these autoantibodies are not specific to the disease and not all patients present with them. We report the case of a 4-year-old girl suffering from RE displaying some atypical features such as fast evolution and seizures of left parietal onset refractory to several antiepileptics, intravenous immunoglobulins, and corticosteroids. Serum autoantibodies directed against voltage-gated potassium channels (VGKC) were evidenced at 739 pM, a finding never previously reported in children. This screening was performed because of an increased signal in the temporolimbic areas on brain magnetic resonance imaging, which was similar to what is observed during limbic encephalitis. The patient experienced epilepsia partialis continua with progressive right hemiplegia and aphasia. She underwent left hemispherotomy at the age of 5.5 years after which she became seizure free with great cognitive improvement. First described in adults, VGKC autoantibodies have been recently described in children with various neurological manifestations. The implication of VGKC autoantibodies in RE is a new observation and opens up new physiopathological and therapeutic avenues of investigation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1055/s-0034-1383822

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[PMID]: 25150668
[Au] Autor:Li S; Chang SH; Francisco GE; Verduzco-Gutierrez M
[Ad] Address:Department of Physical Medicine and Rehabilitation, The University of Texas Health Science Center at Houston, Houston, Texas Neurorehabilitation Research Laboratory, Neurorecovery Research Center, TIRR Memorial Hermann Research Center, Houston, Texas....
[Ti] Title:Acoustic startle reflex in patients with chronic stroke at different stages of motor recovery: a pilot study.
[So] Source:Top Stroke Rehabil;21(4):358-70, 2014 Jul-Aug.
[Is] ISSN:1074-9357
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Acoustic startle reflex (ASR) can be used as a tool to examine reticulospinal excitability. The potential role of reticulospinal mechanisms in the development of spasticity has been suggested but not tested. OBJECTIVE: To examine reticulospinal excitability at different stages of motor recovery in patients with chronic stroke using the ASR. METHODS: Sixteen subjects with hemiplegic stroke participated in the study. We examined ASR responses at rest and contralateral motor overflow during voluntary elbow flexion. RESULTS: ASR responses in impaired biceps muscles showed different patterns at different stages. In subjects without spasticity, ASR responses were less frequent (10% on impaired side) and had normal duration (<200 ms). In subjects with spasticity, the responses were more frequent (58.3% on impaired side) and longer lasting (up to 1 minute). However, no correlation between exaggerated reflex responses and Modified Ashworth Scale (MAS) scores was observed. During voluntary elbow flexion on the impaired side, similar positive linear force-electromyogram (EMG) relationships were found in subjects with and without spasticity. Electromyographic activity of the resting nonimpaired limb increased proportionally in subjects with spasticity (r = 0.6313, P = .0004), but no such correlation was found in subjects without spasticity (r = 0.0191, P = .9612). CONCLUSIONS: Preliminary findings of exaggerated ASR responses and associated contralateral overflow only in spastic biceps muscles in patients with chronic stroke suggest the important role of reticulospinal mechanisms in the development of spasticity.
[Mh] MeSH terms primary: Recovery of Function
Startle Reaction/physiology
Stroke/psychology
Stroke/rehabilitation
[Mh] MeSH terms secundary: Acoustic Stimulation
Adult
Aged
Chronic Disease
Data Interpretation, Statistical
Electromyography
Female
Hemiplegia/etiology
Hemiplegia/rehabilitation
Humans
Male
Middle Aged
Muscle Contraction/physiology
Neurologic Examination
Pilot Projects
Reflex/physiology
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Entry month:1409
[Js] Journal subset:IM
[Da] Date of entry for processing:140825
[St] Status:MEDLINE
[do] DOI:10.1310/tsr2104-358


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