Database : MEDLINE
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[PMID]: 27252036
[Au] Autor:Beinvogl BC; Rosman NP; Baumer FM; Rodan LH; Forster CS; Kwon AH; Berry GT
[Ad] Address:Division of General Pediatrics, Department of Pediatrics, beate.beinvogl@childrens.harvard.edu....
[Ti] Title:A 10-Month-Old With Intermittent Hypotonia and Paralysis.
[So] Source:Pediatrics;138(1), 2016 Jul.
[Is] ISSN:1098-4275
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:A 10-month-old boy presented with a 1-day history of flaccid quadriplegia and dysconjugate gaze. His history was remarkable for stereotyped episodes of flaccid quadriplegia or hemiplegia, oculomotor abnormalities, and limb or neck posturing, beginning in the first days of life and becoming more frequent and more prolonged over time. The patient was healthy and developmentally normal between episodes. Results of extensive laboratory evaluations, including EEG and brain imaging studies, were negative. The patient's history, diagnostic evaluation, and final diagnosis are reviewed. This case illustrates the importance of a fundamental understanding of neurologic localization in pediatric care and a focused diagnostic approach to an infant with paroxysmal neurologic signs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1607
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review

  2 / 12444 MEDLINE  
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[PMID]: 26089043
[Au] Autor:O'Neil ME; Fragala-Pinkham M; Lennon N; George A; Forman J; Trost SG
[Ad] Address:M.E. O'Neil, PT, PhD, MPH, Department of Physical Therapy and Rehabilitation Sciences, Drexel University, 1601 Cherry St, Mail Stop 7502, Philadelphia, PA 19102 (USA). moneil@drexel.edu....
[Ti] Title:Reliability and Validity of Objective Measures of Physical Activity in Youth With Cerebral Palsy Who Are Ambulatory.
[So] Source:Phys Ther;96(1):37-45, 2016 Jan.
[Is] ISSN:1538-6724
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Physical therapy for youth with cerebral palsy (CP) who are ambulatory includes interventions to increase functional mobility and participation in physical activity (PA). Thus, reliable and valid measures are needed to document PA in youth with CP. OBJECTIVE: The purpose of this study was to evaluate the inter-instrument reliability and concurrent validity of 3 accelerometer-based motion sensors with indirect calorimetry as the criterion for measuring PA intensity in youth with CP. METHODS: Fifty-seven youth with CP (mean age=12.5 years, SD=3.3; 51% female; 49.1% with spastic hemiplegia) participated. Inclusion criteria were: aged 6 to 20 years, ambulatory, Gross Motor Function Classification System (GMFCS) levels I through III, able to follow directions, and able to complete the full PA protocol. Protocol activities included standardized activity trials with increasing PA intensity (resting, writing, household chores, active video games, and walking at 3 self-selected speeds), as measured by weight-relative oxygen uptake (in mL/kg/min). During each trial, participants wore bilateral accelerometers on the upper arms, waist/hip, and ankle and a portable indirect calorimeter. Intraclass coefficient correlations (ICCs) were calculated to evaluate inter-instrument reliability (left-to-right accelerometer placement). Spearman correlations were used to examine concurrent validity between accelerometer output (activity and step counts) and indirect calorimetry. Friedman analyses of variance with post hoc pair-wise analyses were conducted to examine the validity of accelerometers to discriminate PA intensity across activity trials. RESULTS: All accelerometers exhibited excellent inter-instrument reliability (ICC=.94-.99) and good concurrent validity (rho=.70-.85). All accelerometers discriminated PA intensity across most activity trials. LIMITATIONS: This PA protocol consisted of controlled activity trials. CONCLUSIONS: Accelerometers provide valid and reliable measures of PA intensity among youth with CP.
[Mh] MeSH terms primary: Accelerometry/instrumentation
Cerebral Palsy/physiopathology
Cerebral Palsy/therapy
Motor Activity
Physical Therapy Modalities
[Mh] MeSH terms secundary: Activities of Daily Living
Adolescent
Child
Female
Humans
Male
Reproducibility of Results
Young Adult
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; VALIDATION STUDIES
[Em] Entry month:1605
[Cu] Class update date: 160701
[Lr] Last revision date:160701
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:160102
[St] Status:MEDLINE
[do] DOI:10.2522/ptj.20140201

  3 / 12444 MEDLINE  
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[PMID]: 26410208
[Au] Autor:Gálvez J; Estrada-Reyes R; Benítez-King G; Araujo G; Orozco S; Fernández-Mas R; Almazán S; Calixto E
[Ad] Address:Department of Neurobiology, National Institute of Psichiatry, D.F., México....
[Ti] Title:Involvement of the GABAergic system in the neuroprotective and sedative effects of acacetin 7-O-glucoside in rodents.
[So] Source:Restor Neurol Neurosci;33(5):683-700, 2015.
[Is] ISSN:1878-3627
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:PURPOSE: Characterization of sedative, possible anticonvulsant, and protective effects of Acacetin-7-O-glucoside (7-ACAG). METHODS: 7-ACAG was separated and its purity was analyzed. Its sedative and anti-seizure effects (1, 10, 20, and 40 mg/kg) were evaluated in male mice. Synaptic responses were acquired from area CA1 of hippocampal slices obtained from male Wistar rats. Rats were subjected to stereotaxic surgeries to allow Electroencephalographic (EEG) recordings. Functional recovery was evaluated by measuring the time rats spent in completing the motor task. Then the rats were subjected to right hemiplegia and administered 7-ACAG (40 mg/kg) 1 h or 24 h after surgery. Brains of each group of rats were prepared for histological analysis. RESULTS: Effective sedative doses of 7-ACAG comprised those between 20 and 40 mg/kg. Latency and duration of the epileptiform crisis were delayed by this flavonoid. 7-ACAG decreased the synaptic response in vitro, similar to Gamma-aminobutyric acid (GABA) effects. The flavonoid facilitated functional recovery. This data was associated with preserved cytoarchitecture in brain cortex and hippocampus. CONCLUSIONS: 7-ACAG possesses anticonvulsive and sedative effects. Results suggest that GABAergic activity and neuroprotection are involved in the mechanism of action of 7-ACAG and support this compound's being a potential drug for treatment of anxiety or post-operative conditions caused by neurosurgeries.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1510
[Cu] Class update date: 160630
[Lr] Last revision date:160630
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.3233/RNN-140486

  4 / 12444 MEDLINE  
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[PMID]: 27346996
[Au] Autor:Machado S; Lattari E; Paes F; Rocha NB; Nardi AE; Arias-Carrión O; Mura G; Yuan TF; Carta MG; Campos C
[Ad] Address:Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro (IPUB/UFRJ), Rio de Janeiro, Brazil; Physical Activity Neuroscience Laboratory, Physical Activity Sciences Postgraduate Program, Salgado de Oliveira University, Niterói, Brazil....
[Ti] Title:Mental Practice Combined with Motor Rehabilitation to Treat Upper Limb Hemiparesis of Post-Stroke Patients: Clinical and Experimental Evidence.
[So] Source:Clin Pract Epidemiol Ment Health;12:9-13, 2016.
[Is] ISSN:1745-0179
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Stroke is one of the major causes of disability in the world. Due to the extended lifetime of the world's population, the number of people affected by stroke has increased substantially over the last years. Stroke may lead to sensorimotor deficits, usually causing hemiplegia or hemiparesia. In order to reduce motor deficits and accelerate functional recovery, MP combined with motor rehabilitation was introduced to the rehabilitation process of post-stroke patients. Evidence has shown that MP combining with motor rehabilitation based on activities of daily living was more effective than conventional motor rehabilitation used per se. This combination proved very useful and effective, with significant results in improvement of motor deficits in post-stroke patients. However, further studies must be conducted to determine specific parameters, such as type of imagery, frequency or duration.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Cu] Class update date: 160629
[Lr] Last revision date:160629
[Da] Date of entry for processing:160627
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.2174/1745017901612010009

  5 / 12444 MEDLINE  
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[PMID]: 27276195
[Au] Autor:Kirshenbaum GS; Idris NF; Dachtler J; Roder JC; Clapcote SJ
[Ad] Address:a Lunenfeld-Tanenbaum Research Institute , Mount Sinai Hospital , University Avenue , Toronto , Canada ;...
[Ti] Title:Deficits in social behavioral tests in a mouse model of alternating hemiplegia of childhood.
[So] Source:J Neurogenet;30(1):42-9, 2016 Mar.
[Is] ISSN:1563-5260
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Social behavioral deficits have been observed in patients diagnosed with alternating hemiplegia of childhood (AHC), rapid-onset dystonia-parkinsonism and CAPOS syndrome, in which specific missense mutations in ATP1A3, encoding the Na(+), K(+)-ATPase α3 subunit, have been identified. To test the hypothesis that social behavioral deficits represent part of the phenotype of Na(+), K(+)-ATPase α3 mutations, we assessed the social behavior of the Myshkin mouse model of AHC, which has an I810N mutation identical to that found in an AHC patient with co-morbid autism. Myshkin mice displayed deficits in three tests of social behavior: nest building, pup retrieval and the three-chamber social approach test. Chronic treatment with the mood stabilizer lithium enhanced nest building in wild-type but not Myshkin mice. In light of previous studies revealing a broad profile of neurobehavioral deficits in the Myshkin model - consistent with the complex clinical profile of AHC - our results suggest that Na(+), K(+)-ATPase α3 dysfunction has a deleterious, but nonspecific, effect on social behavior. By better defining the behavioral profile of Myshkin mice, we identify additional ATP1A3-related symptoms for which the Myshkin model could be used as a tool to advance understanding of the underlying neural mechanisms and develop novel therapeutic strategies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Cu] Class update date: 160629
[Lr] Last revision date:160629
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1080/01677063.2016.1182525

  6 / 12444 MEDLINE  
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[PMID]: 26932935
[Au] Autor:Brunet K; Minoza A; Portet S; Beraud G; Rodier MH; Cateau E
[Ti] Title:A 55-Year-Old French Man With Sudden Hemiparesis and Hemiplegia.
[So] Source:Clin Infect Dis;62(6):777, 807-8, 2016 Mar 15.
[Is] ISSN:1537-6591
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1603
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1093/cid/civ1192

  7 / 12444 MEDLINE  
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[PMID]: 26811254
[Au] Autor:Besharati S; Forkel SJ; Kopelman M; Solms M; Jenkinson PM; Fotopoulou A
[Ad] Address:1 Department of Psychology, King's College London, Institute of Psychiatry, Psychology, and Neuroscience, UK 2 Department of Psychology, University of Cape Town, South Africa 3 Clinical, Educational and Health Psychology, Division of Psychology and Language Sciences, University College London, UK....
[Ti] Title:Mentalizing the body: spatial and social cognition in anosognosia for hemiplegia.
[So] Source:Brain;139(Pt 3):971-85, 2016 Mar.
[Is] ISSN:1460-2156
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Following right-hemisphere damage, a specific disorder of motor awareness can occur called anosognosia for hemiplegia, i.e. the denial of motor deficits contralateral to a brain lesion. The study of anosognosia can offer unique insights into the neurocognitive basis of awareness. Typically, however, awareness is assessed as a first person judgement and the ability of patients to think about their bodies in more 'objective' (third person) terms is not directly assessed. This may be important as right-hemisphere spatial abilities may underlie our ability to take third person perspectives. This possibility was assessed for the first time in the present study. We investigated third person perspective taking using both visuospatial and verbal tasks in right-hemisphere stroke patients with anosognosia (n = 15) and without anosognosia (n = 15), as well as neurologically healthy control subjects (n = 15). The anosognosic group performed worse than both control groups when having to perform the tasks from a third versus a first person perspective. Individual analysis further revealed a classical dissociation between most anosognosic patients and control subjects in mental (but not visuospatial) third person perspective taking abilities. Finally, the severity of unawareness in anosognosia patients was correlated to greater impairments in such third person, mental perspective taking abilities (but not visuospatial perspective taking). In voxel-based lesion mapping we also identified the lesion sites linked with such deficits, including some brain areas previously associated with inhibition, perspective taking and mentalizing, such as the inferior and middle frontal gyri, as well as the supramarginal and superior temporal gyri. These results suggest that neurocognitive deficits in mental perspective taking may contribute to anosognosia and provide novel insights regarding the relation between self-awareness and social cognition.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1602
[Cu] Class update date: 160227
[Lr] Last revision date:160227
[Js] Journal subset:AIM; IM
[St] Status:In-Process
[do] DOI:10.1093/brain/awv390

  8 / 12444 MEDLINE  
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[PMID]: 26559257
[Au] Autor:Kong Y; Li H; Wang J; Chai Y; Hou W; Zhang N
[Ad] Address:From the Department of Medicine Oncology, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei (YK); Postgraduate School, Tianjin Medical University, Heping, Tianjin (HL); Department of Orthopedics, The Fourth Affiliated Hospital of Hebei Medical University, (JW); Department of Respiration, The Second Affiliated Hospital of Hebei Medical University (YC); Department of Cardiac Surgery (WH); and Department of Cardiology, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China (NZ).
[Ti] Title:Left Ventricular Myxoma Leading to Stroke: A Rare Case Report.
[So] Source:Medicine (Baltimore);94(45):e1913, 2015 Nov.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Primary cardiac tumors are rare, and most are myxomas. Only approximately 5% of cardiac myxomas originate from the ventricles.We report the case of a 23-year-old man presenting with right hemiplegia and muscle strength degeneration under a diagnosis of stroke. Transthoracic echocardiography revealed a 29 × 26 mm mass arising from the anterior interventricular septum. The tumor was surgically removed, and histology confirmed the diagnosis of left ventricular myxoma.We report its clinical features and treatment to add to the current knowledge.
[Mh] MeSH terms primary: Heart Neoplasms/complications
Myxoma/complications
Stroke/etiology
[Mh] MeSH terms secundary: Heart Neoplasms/diagnosis
Heart Neoplasms/surgery
Heart Ventricles
Humans
Male
Myxoma/diagnosis
Myxoma/surgery
Young Adult
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1602
[Cu] Class update date: 160629
[Lr] Last revision date:160629
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:151112
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000001913

  9 / 12444 MEDLINE  
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[PMID]: 24376067
[Au] Autor:Brandão MB; Ferre C; Kuo HC; Rameckers EA; Bleyenheuft Y; Hung YC; Friel K; Gordon AM
[Ad] Address:Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, Brazil....
[Ti] Title:Comparison of Structured Skill and Unstructured Practice During Intensive Bimanual Training in Children With Unilateral Spastic Cerebral Palsy.
[So] Source:Neurorehabil Neural Repair;28(5):452-61, 2014 Jun.
[Is] ISSN:1552-6844
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:UNLABELLED: Background High-intensity training aims to improve hand function in children with unilateral spastic cerebral palsy (USCP). However, the extent to which skill training is required is not known. Objectives To compare the effects of intensive bimanual training with and without structured progression of skill difficulty, on manual dexterity, bimanual hand use, daily functioning, and functional goals in children with USCP. Method Twenty-two children were randomized to structured practice group (SPG) or unstructured practice group (UPG), and received 6 h/d training during 15 days. Children from the SPG were engaged in fine and gross motor bimanual activities, with skill progression and goal training. Children from UPG performed the same activities without skill progression or goal training. Participants were evaluated before, immediately and 6 months after training by a physical therapist blinded to group allocation. The primary outcomes were the Jebsen-Taylor Test of Hand Function (JTTHF) and Assisting Hand Assessment (AHA). Secondary outcomes included the Canadian Occupational Performance Measure (COPM), Pediatric Evaluation of Disability Inventory (PEDI), and ABILHAND-Kids. Results Both groups showed similar improvements in the JTTHF, AHA, ABILHAND-Kids, COPM-satisfaction, and PEDI (P < .05). A significant interaction in the COPM-performance scale (P = .03) showed superior improvements of the SPG immediately, but not 6 months, after the intervention. CONCLUSIONS: Children from both groups demonstrated improvements in dexterity and functional hand use. This suggests that for intensive bimanual approaches, intensive training at such high doses may not require structured practice to elicit improvements. However, there may be immediate added benefit of including goal training.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1177/1545968313516871

  10 / 12444 MEDLINE  
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[PMID]: 26882285
[Au] Autor:Borah S; McConnell B; Hughes R; Kluger B
[Ad] Address:a Department of Neurology , University of Colorado Denver , Aurora , CO , USA....
[Ti] Title:Potential relationship of self-injurious behavior to right temporo-parietal lesions.
[So] Source:Neurocase;22(3):269-72, 2016 Jun.
[Is] ISSN:1465-3656
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Self-injurious behavior (SIB) is associated with several neurologic and psychiatric syndromes but rarely with focal lesions. Two patients with lesions of the right temporo-parietal junction presented to psychiatric inpatient services with SIB in the absence of notable neurologic deficits or suicidal ideation. Right temporo-parietal lesions may be associated with disturbances of agency and body ownership, both of which may facilitate SIB. Misoplegia, or hatred of a limb, may be associated with SIB and has been reported without hemiplegia with a right temporo-parietal lesion. Further study is warranted to improve our understanding of the mechanisms underlying SIB.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1080/13554794.2016.1147586


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