Database : MEDLINE
Search on : Hemiplegia [Words]
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[PMID]: 25229023
[Au] Autor:Nam HU; Huh JS; Yoo JN; Hwang JM; Lee BJ; Min YS; Kim CH; Jung TD
[Ad] Address:Department of Rehabilitation Medicine, Kyungpook National University College of Medicine, Daegu, Korea....
[Ti] Title:Effect of dominant hand paralysis on quality of life in patients with subacute stroke.
[So] Source:Ann Rehabil Med;38(4):450-7, 2014 Aug.
[Is] ISSN:2234-0645
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To evaluate the degree to which the paralysis of a dominant hand affects quality of life (QOL) in patients with subacute stroke. METHODS: We recruited 75 patients with subacute hemiplegic stroke. Patients were divided into two groups according to the location of the lesion and the side of the dominant hand. Group 1 consisted of patients whose strokes affected the dominant hand (i.e., right hemiplegia and right dominant hand or left hemiplegia and left dominant hand). Group 2 consisted of patients whose strokes affected the non-dominant hand (i.e., left hemiplegia and right dominant hand or right hemiplegia and left dominant hand). The primary outcome measure was the Short-Form 36-Item Health Survey (SF-36), which was used to evaluate health-related QOL. Secondary outcomes were scores on the Modified Barthel Index (MBI) and Beck Depression Inventory (BDI). RESULTS: We did not find any statistically significant differences between the groups in any SF-36 domain including the summaries of physical and mental component. Similarly, the MBI and BDI scores were not significantly different between the groups. CONCLUSION: The effect of paralysis on the dominant hand and QOL in patients with subacute stroke was not significantly different from the effect of paralysis on the non-dominant hand.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Cu] Class update date: 140919
[Lr] Last revision date:140919
[Da] Date of entry for processing:140917
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.5535/arm.2014.38.4.450

  2 / 11730 MEDLINE  
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[PMID]: 25098330
[Au] Autor:Ge W; Kuang H; Wei B; Bo L; Xu Z; Xu X; Geng D; Sun M
[Ad] Address:Institute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou City, Jiangsu, China; Department of Neurology, the Affiliated Hospital of Xuzhou Medical College, Xuzhou City, Jiangsu, China; Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou Cit...
[Ti] Title:A novel cysteine-sparing NOTCH3 mutation in a Chinese family with CADASIL.
[So] Source:PLoS One;9(8):e104533, 2014.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an adult onset cerebral small vessel disorder caused by the mutations of the neurogenic locus notch homolog protein 3 (NOTCH3) gene. The extracellular part of NOTCH3 is composed of 34 epidermal growth factor-like (EGF-like) repeat domains. Each EGF-like domain is rich of cysteine and glycine to produce three loops that are essential for high-affinity binding to its ligand. Nearly all reported CADASIL-associated mutations result in gain or loss of a cysteine residue within the EGF-like domains. Only a few cysteine-sparing NOTCH3 mutations have been documented in the patients with CADASIL to date. Here, we reported a Chinese CADASIL family with a cysteine-sparing NOTCH3 mutation. In this family, affected patients had dizziness, memory loss, gait instability, or hemiplegia. Brain magnetic resonance imaging (MRI) showed diffuse leukoencephalopathy with confluent signal abnormalities in the periventricular white matter, basal ganglia, and centrum semiovale bilaterally. By screening the entire coding region of NOTCH3, a novel missense mutation p.G149V (c.446G>T) was found. This mutation was not detected in 400 normal controls. Considering the critical position of glycine within the C-loop of EGF-like domain and its high conservation through evolution, p.G149V mutation could be a potential pathogenic cause for CADASIL.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1371/journal.pone.0104533

  3 / 11730 MEDLINE  
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[PMID]: 24769123
[Au] Autor:Suriya-amarit D; Gaogasigam C; Siriphorn A; Boonyong S
[Ad] Address:Department of Physical Therapy, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand....
[Ti] Title:Effect of interferential current stimulation in management of hemiplegic shoulder pain.
[So] Source:Arch Phys Med Rehabil;95(8):1441-6, 2014 Aug.
[Is] ISSN:1532-821X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To study the immediate effects of interferential current stimulation (IFC) on shoulder pain and pain-free passive range of motion (PROM) of the shoulder in people with hemiplegic shoulder pain (HSP). DESIGN: Double-blind, placebo-controlled clinical trial. SETTING: Institutional physical therapy clinic, neurologic rehabilitation center. PARTICIPANTS: A population-based sample of people with HSP (N=30) was recruited. INTERVENTION: Participants were divided into 2 groups--an IFC group and a placebo group--by using a match-paired method (age, sex, and Brunnstrom motor recovery stage). In the IFC group, participants received IFC for 20 minutes with an amplitude-modulated frequency at 100 Hz in vector mode. The current intensity was increased until the participants felt a strong tingling sensation. MAIN OUTCOME MEASURES: Pain intensity and pain-free PROM of the shoulder until the onset of pain were measured at baseline and immediately after treatment. RESULTS: Participants reported a greater reduction in pain during the most painful movement after treatment with IFC than with placebo (P<.05). The IFC group showed a greater improvement in posttreatment pain-free PROM than the placebo group in shoulder flexion (P<.01), abduction (P<.01), internal rotation (P<.01), and external rotation (P<.01). CONCLUSIONS: This study provides evidence that IFC is effective for the relief of pain during movement and also increases the pain-free PROM of the shoulder in people with HSP.
[Mh] MeSH terms primary: Electric Stimulation Therapy
Hemiplegia/complications
Shoulder Pain/therapy
[Mh] MeSH terms secundary: Aged
Double-Blind Method
Female
Humans
Male
Matched-Pair Analysis
Middle Aged
Range of Motion, Articular
Rotation
Shoulder Joint/physiopathology
Shoulder Pain/etiology
Shoulder Pain/physiopathology
[Pt] Publication type:CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1409
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:140728
[St] Status:MEDLINE

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[PMID]: 24742939
[Au] Autor:Chen HC; Chen CL; Kang LJ; Wu CY; Chen FC; Hong WH
[Ad] Address:Department of Industrial Engineering and Management, National Taipei University of Technology, Taipei....
[Ti] Title:Improvement of upper extremity motor control and function after home-based constraint induced therapy in children with unilateral cerebral palsy: immediate and long-term effects.
[So] Source:Arch Phys Med Rehabil;95(8):1423-32, 2014 Aug.
[Is] ISSN:1532-821X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To investigate the long-term effects of home-based constraint induced therapy (CIT) on motor control underlying functional change in children with unilateral cerebral palsy (CP). DESIGN: Randomized controlled trial. SETTING: Home based. PARTICIPANTS: Children with unilateral CP (N=45; aged 6-12 y) were randomly assigned to receive home-based CIT (n=23) or traditional rehabilitation (TR) (n=22). INTERVENTIONS: Both groups received a 4-week therapist-based intervention at home. The home-based CIT involved intensive functional training of the more affected upper extremity during which the less affected one was restrained. The TR involved functional unimanual and bimanual training. MAIN OUTCOME MEASURES: All children underwent kinematic and clinical assessments at baseline, 4 weeks (posttreatment), and 3 and 6 months (follow-up). The reach-to-grasp kinematics were reaction time (RT), normalized movement time, normalized movement unit, peak velocity (PV), maximum grip aperture (MGA), and percentage of movement where MGA occurs. The clinical measures were the Peabody Developmental Motor Scales, Second Edition (PDMS-2), Bruininks-Oseretsky Test of Motor Proficiency (BOTMP), and Functional Independence Measure for children (WeeFIM). RESULTS: The home-based CIT group showed a shorter RT (P<.05) and normalized movement time (P<.01), smaller MGA (P=.006), and fewer normalized movement units (P=.014) in the reach-to-grasp movements at posttreatment and follow-up than the TR group. The home-based CIT group improved more on the PDMS-2 (P<.001) and WeeFIM (P<.01) in all posttreatment tests and on the BOTMP (P<.01) at follow-up than the TR group. CONCLUSIONS: The home-based CIT induced better spatial and temporal efficiency (smoother movement, more efficient grasping, better movement preplanning and execution) for functional improvement up to 6 months after treatment than TR.
[Mh] MeSH terms primary: Cerebral Palsy/physiopathology
Cerebral Palsy/rehabilitation
Hemiplegia/physiopathology
Hemiplegia/rehabilitation
Home Care Services
Psychomotor Performance
Restraint, Physical
Upper Extremity/physiopathology
[Mh] MeSH terms secundary: Biomechanical Phenomena
Child
Female
Humans
Male
Movement
Reaction Time
Single-Blind Method
Time Factors
[Pt] Publication type:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1409
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:140728
[St] Status:MEDLINE

  5 / 11730 MEDLINE  
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[PMID]: 24123283
[Au] Autor:Sasaki M; Ishii A; Saito Y; Hirose S
[Ad] Address:Department of Child Neurology, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
[Ti] Title:Intermediate form between alternating hemiplegia of childhood and rapid-onset dystonia-parkinsonism.
[So] Source:Mov Disord;29(1):153-4, 2014 Jan.
[Is] ISSN:1531-8257
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Dystonic Disorders/diagnosis
Hemiplegia/diagnosis
[Mh] MeSH terms secundary: Child
Dystonic Disorders/physiopathology
Hemiplegia/physiopathology
Humans
Male
[Pt] Publication type:CASE REPORTS; LETTER; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1409
[Js] Journal subset:IM
[Da] Date of entry for processing:140124
[St] Status:MEDLINE
[do] DOI:10.1002/mds.25659

  6 / 11730 MEDLINE  
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[PMID]: 24917491
[Au] Autor:Patiroglu T; Isik B; Unal E; Canoz O; Deniz K; Kosemehmetoglu K; Karakukcu M; Ozdemir MA
[Ad] Address:Division of Pediatric Hematology and Oncology, Department of Pediatrics, Faculty of Medicine, Erciyes University, 38039, Talas, Kayseri, Turkey, turkanp@erciyes.edu.tr.
[Ti] Title:Cranial metastatic alveolar rhabdomyosarcoma mimicking hematological malignancy in an adolescent boy.
[So] Source:Childs Nerv Syst;30(10):1737-41, 2014 Oct.
[Is] ISSN:1433-0350
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:BACKGROUND: Widespread alveolar rhabdomyosarcoma (ARMS) with bone marrow involvement and with an unknown primary tumor, especially presenting with acute tumor lysis syndrome can be easily misdiagnosed as a hematological malignancy. Furthermore, brain metastasis of ARMS is rare seen in children. CASE REPORT: Herein, we report a 14-year-old boy presenting with acute tumor lysis syndrome due to bone marrow invasion of ARMS, who was diagnosed after abdominal paraaortic lymph node biopsy. Despite radiological and nuclear medicine imaging, the primary tumor site could not be found. He was treated with vincristine, topotecan, and cyclophosphamide for 42 weeks. Six months after the completion of treatment, he suffered from severe headache, blurred vision, right hemiplegia, and severe bone pain. Cranial magnetic resonance imaging showed multiple hemorrhagic infarctions. Brain biopsy showed brain metastasis with PAX3-FKHR fusion transcript. CONCLUSION: The clinicians must be vigilant about solely brain metastasis in ARMS without additional metastasis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00381-014-2443-2

  7 / 11730 MEDLINE  
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[PMID]: 25049388
[Au] Autor:Stangenberg L; Burzyn D; Binstadt BA; Weissleder R; Mahmood U; Benoist C; Mathis D
[Ad] Address:Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114; and....
[Ti] Title:Denervation protects limbs from inflammatory arthritis via an impact on the microvasculature.
[So] Source:Proc Natl Acad Sci U S A;111(31):11419-24, 2014 Aug 5.
[Is] ISSN:1091-6490
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Two-way communication between the mammalian nervous and immune systems is increasingly recognized and appreciated. An intriguing example of such crosstalk comes from clinical observations dating from the 1930s: Patients who suffer a stroke and then develop rheumatoid arthritis atypically present with arthritis on only one side, the one not afflicted with paralysis. Here we successfully modeled hemiplegia-induced protection from arthritis using the K/BxN serum-transfer system, focused on the effector phase of inflammatory arthritis. Experiments entailing pharmacological inhibitors, genetically deficient mouse strains, and global transcriptome analyses failed to associate the protective effect with a single nerve quality (i.e., with the sympathetic, parasympathetic, or sensory nerves). Instead, there was clear evidence that denervation had a long-term effect on the limb microvasculature: The rapid and joint-localized vascular leak that typically accompanies and promotes serum-transferred arthritis was compromised in denervated limbs. This defect was reflected in the transcriptome of endothelial cells, the expression of several genes impacting vascular leakage or transendothelial cell transmigration being altered in denervated limbs. These findings highlight a previously unappreciated pathway to dissect and eventually target in inflammatory arthritis.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1073/pnas.1410854111

  8 / 11730 MEDLINE  
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[PMID]: 25221586
[Au] Autor:Zhang L; Li P; Mao Z; Qi X; Zou J; Yu Z
[Ad] Address:Shanghai University of Sport, Shanghai 200438, China....
[Ti] Title:Changes in motor function in the unaffected hand of stroke patients should not be ignored.
[So] Source:Neural Regen Res;9(13):1323-8, 2014 Jul 1.
[Is] ISSN:1673-5374
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Motor function changes in the unaffected hand of stroke patients with hemiplegia. These changes are often ignored by clinicians owing to the extent of motor disability of the affected hand. Finger tapping frequency and Lind-mark hand function score showed that the motor function of unaffected hands in stroke patients was poorer than that of a healthy control hand. After 2 weeks of rehabilitation treatment, motor function of the unaffected hand of stroke patients was obviously improved. Therefore, attention should also be paid to motor function in the unaffected hand of stroke patients with hemiplegia during rehabilitation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Cu] Class update date: 140917
[Lr] Last revision date:140917
[Da] Date of entry for processing:140915
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/1673-5374.137581

  9 / 11730 MEDLINE  
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[PMID]: 25228575
[Au] Autor:Haefeli M; Calcagni M
[Ad] Address:Klinik für Plastische Chirurgie und Handchirurgie, Universitätsspital Zürich.
[Ti] Title:Hemiplegie und Zerebralparese - multidisziplinäre Behandlung der spastischen oberen Extremität. [In Process Citation].
[So] Source:Praxis (Bern 1994);103(19):1133-9, 2014 Sep 1.
[Is] ISSN:1661-8157
[Cp] Country of publication:Switzerland
[La] Language:ger
[Ab] Abstract:Spastic hemiplegia and cerebral palsy often lead to typical deformities of the upper extremity. Muscle- and joint-contractures may be painful and aesthetically unappealing and may interfere with function and hygiene. Within the first weeks after the cerebral incidence the vital threat is dominating and the exact amount of neurologic impairment is not assessable. During this period, conservative treatment should counteract the development of contractures. After spontaneous neurologic recovery, surgical options should be taken into account. When choosing surgical procedures, factors as volitional motor control, sensibility and cognition must be taken into account besides the morphologic changes. This is best achieved in a multidisciplinary setting of neurologists, rehabilitation specialists, physiotherapists and surgeons.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1024/1661-8157/a001783

  10 / 11730 MEDLINE  
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[PMID]: 25089908
[Au] Autor:Domagalska-Szopa M; Szopa A
[Ad] Address:Institute of Medical Rehabilitation, Department of Physiotherapy, School of Health Sciences, Medical University of Silesia, Katowice, Poland.
[Ti] Title:Gait pattern differences between children with mild scoliosis and children with unilateral cerebral palsy.
[So] Source:PLoS One;9(8):e103095, 2014.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:This study was conducted to investigate the effects of asymmetrical body posture alone, i.e., the effects seen in children with mild scoliosis, vs. the effects of body posture control impairment, i.e., those seen in children with unilateral cerebral palsy on gait patterns. Three-dimensional instrumented gait analysis (3DGA) was conducted in 45 children with hemiplegia and 51 children with mild scoliosis. All the children were able to walk without assistance devices. A set of 35 selected spatiotemporal gait and kinematics parameters were evaluated when subjects walked on a treadmill. A cluster analysis revealed 3 different gait patterns: a scoliotic gait pattern and 2 different hemiplegic gait patterns. The results showed that the discrepancy in gait patterns was not simply a lower limb kinematic deviation in the sagittal plane, as expected. Additional altered kinematics, such as pelvic misorientation in the coronal plane in both the stance and swing phases and inadequate stance phase hip ad/abduction, which resulted from postural pattern features, were distinguished between the 3 gait patterns. Our study provides evidence for a strong correlation between postural and gait patterns in children with unilateral cerebral palsy. Information on differences in gait patterns may be used to improve the guidelines for early therapy for children with hemiplegia before abnormal gait patterns are fully established. The gait pathology characteristic of scoliotic children is a potential new direction for treating scoliosis that complements the standard posture and walking control therapy exercises with the use of biofeedback.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1371/journal.pone.0103095


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