Database : MEDLINE
Search on : Hemiplegia [Words]
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[PMID]: 24100174
[Au] Autor:Hoei-Hansen CE; Dali CÍ; Lyngbye TJ; Duno M; Uldall P
[Ad] Address:Department of Paediatrics, University Hospital Hilleroed, Denmark. Electronic address: chh@dadlnet.dk....
[Ti] Title:Alternating hemiplegia of childhood in Denmark: clinical manifestations and ATP1A3 mutation status.
[So] Source:Eur J Paediatr Neurol;18(1):50-4, 2014 Jan.
[Is] ISSN:1532-2130
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Alternating hemiplegia of childhood (AHC) is a rare neurodevelopmental disorder characterized by early-onset recurrent distinctive hemiplegic episodes commonly accompanied by other paroxysmal features and developmental impairment. De novo mutations in ATP1A3 were recently identified as a genetic cause of AHC. To describe the entire Danish cohort of paediatric AHC patients we approached neuropaediatricians nationwide. All currently acknowledged Danish patients ≤16 years with AHC were genetically tested and seen by the same child neurologist (PU). Ten patients; seven girls and three boys were identified. Mean present age was 10.0 years (range 1-16). Mean age at presentation was 7.4 months (range 1-18 months). Sequencing of ATP1A3 in all ten patients revealed a pathogenic mutation in seven. Two females with moderate psychomotor impairment were heterozygous for the known p.G947R mutation, whereas one severely retarded boy was heterozygous for the common p.E815K mutation. The prevalent p.D801N mutation was identified in two moderate to severely retarded children. Interestingly, in a set of monochorionic male twins a novel p.D801E mutation was identified, underscoring that the asparagine at position 801 is a mutation hotspot. Three girls aged 5-13 years did not reveal any ATP1A3 mutations. They were rather mildly clinically affected and displayed a normal or near-normal psychomotor development. This is the first study of AHC in the Danish paediatric population. The patients harboured a wide range of psychomotor difficulties. Patients with no mutation detected tended to be less severely affected. Prevalence was approximately 1 per 100,000 children.
[Mh] MeSH terms primary: Hemiplegia/genetics
Sodium-Potassium-Exchanging ATPase/genetics
[Mh] MeSH terms secundary: Adolescent
Child
Child, Preschool
Comorbidity
Denmark
Electroencephalography
Female
Genetic Testing
Hemiplegia/epidemiology
Hemiplegia/physiopathology
Humans
Infant
Intellectual Disability/epidemiology
Intellectual Disability/genetics
Intellectual Disability/physiopathology
Male
Mutation/genetics
Prevalence
Severity of Illness Index
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:EC 3.6.3.9 (ATP1A3 protein, human); EC 3.6.3.9 (Sodium-Potassium-Exchanging ATPase)
[Em] Entry month:1410
[Js] Journal subset:IM
[Da] Date of entry for processing:140120
[St] Status:MEDLINE

  2 / 11750 MEDLINE  
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[PMID]: 25295154
[Au] Autor:Baharvahdat H; Etemadrezaie H; Zabyhian S; Valipour Z; Ganjeifar B; Mousavi Mirzaye SM; Sasannejad P; Ghandehari K
[Ad] Address:Department of Neurosurgical, School of Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran....
[Ti] Title:Decompressive craniectomy after unsuccessful intravenous thrombolysis of malignant cerebral infarction.
[So] Source:Iran J Neurol;13(2):101-4, 2014 Apr 3.
[Is] ISSN:2008-384X
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:BACKGROUND: Intravenous recombinant tissue plasminogen activator (rt-PA) is an approved treatment for acute ischemic stroke within 4.5 h of symptoms onset. Decompressive craniectomy (DC) has been shown as an effective therapeutic modality in malignant middle cerebral artery (MCA) infarction. As rt-PA could result in hemorrhagic complication during or after any surgery DC may be associated with severe bleeding after intravenous thrombolysis. CASE DESCRIPTION: A 57-year-old woman was presented 90 min after the sudden onset of left hemiplegia. Despite intravenous thrombolytic therapy, she lost consciousness within 48 h and brain CT scan showed a right malignant MCA infarction associated with a small bleeding. DC was performed without any complication. The patient improved dramatically. CONCLUSION: DC could be done safety for malignant MCA infarction after unsuccessful intravenous thrombolytic therapy even the later was complicated with intra-infarction hemorrhage.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1410
[Cu] Class update date: 141010
[Lr] Last revision date:141010
[Da] Date of entry for processing:141008
[St] Status:PubMed-not-MEDLINE

  3 / 11750 MEDLINE  
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[PMID]: 25084148
[Au] Autor:Nishijima T; Gatanaga H; Teruya K; Tajima T; Kikuchi Y; Hasuo K; Oka S
[Ad] Address:1 AIDS Clinical Center, National Center for Global Health and Medicine , Tokyo, Japan .
[Ti] Title:Brain Magnetic Resonance Imaging Screening Is Not Useful for HIV-1-Infected Patients Without Neurological Symptoms.
[So] Source:AIDS Res Hum Retroviruses;30(10):970-4, 2014 Oct.
[Is] ISSN:1931-8405
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Abstract We investigated the diagnostic usefulness of brain magnetic resonance imaging (MRI) screening in HIV-1-infected patients without neurological symptoms in detecting intracranial diseases at early stages. In this retrospective analysis, the study patients were HIV-1-infected patients who underwent brain MRI scan in clinical practice between 2001 and 2013. We excluded patients with MRI for (1) follow-up examination for prediagnosed intracranial diseases, (2) cancer staging, (3) screening mycobacterium/bacteria/fungi disease proliferation in the brain, and (4) evaluation for meningitis/encephalitis. The study patients (n=485) were classified into two groups: those who underwent brain MRI scan without any neurological symptoms/signs (asymptomatic patients, n=158) and those who underwent MRI due to such symptoms (symptomatic patients, n=327). Asymptomatic patients had lower CD4 counts than symptomatic patients (median 78 versus 241/µl). Intracranial diseases were detected in three (2%) of the asymptomatic patients [two toxoplasmosis and one progressive multifocal leukoencephalopathy (PML)] compared to 58 (19%) of the symptomatic patients (the χ(2) test, p<0.01). The latter included toxoplasmosis (n=10), PML (n=7), cytomegalovirus encephalitis (n=3), primary central nervous system lymphoma (n=3), cryptococcoma/meningitis (n=3), and HIV-associated dementia (n=17). Among symptomatic patients, intracranial diseases were common in those with slurred speech (3/6, 50%), seizure (4/10, 40%), eyesight/vision abnormality (5/16, 31%), altered mental status (8/31, 26%), and hemiplegia/numbness (13/50, 26%). For patients with CD4 count <200/µl, intracranial diseases were detected in only 3 (3%) of 144 asymptomatic patients, compared with 46 (32%) of 113 symptomatic patients (p<0.01). Brain MRI screening for HIV-1-infected patients without neurological symptoms is of little value.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1410
[Js] Journal subset:IM; X
[St] Status:In-Data-Review
[do] DOI:10.1089/AID.2014.0123

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[PMID]: 25172450
[Au] Autor:Wu KZ; Jiang YG; Zuo Y; Li AX
[Ad] Address:The Pharmacy of General Unit of Armed Police Hospital in Jiangxi, Nanchang, 330001, China.
[Ti] Title:Establishment of the method for screening the potential targets and effective components of huatuo reconstruction pill.
[So] Source:Interdiscip Sci;6(2):125-32, 2014 Jun.
[Is] ISSN:1867-1462
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Huatuo reconstruction pill (HTRP) is a traditional Chinese medicine prescription that mainly treats for hemiplegia and postoperation of brain stroke. Existing pharmacological studies have previously shown that HTRP could inhibit in vitro thrombosis, delay platelet adhesion, dilate blood vessels, and improve the microcirculation disturbances. In this paper, we chiefly concerned about the potential targets of HTRP and tried to figure out the active components of it. Computer-aided drug design method was emploied to search for the active components and explain the mechanism between the targets and the small molecules at molecular lever. The potential targets of this compound pharmaceutics were searched through relevant pharmacological studies and three pharmacophore models which involved the platelet activating factor (PAF) receptor, the angiotensin converting enzyme (ACE) and the 5-hydroxytryptamine receptor (5-HT2A) were constructed by Discotech method of Sybyl. Thus, the candidate compounds which agreed with the pharmacophore models were obtained by the virtual screening to the known ingredients of HTRP. Based on that, sequence and structure prediction of the unknown targets were realized by homology modeling which were used for molecular docking with those candidate compounds. Results showed that three compounds, which may prove to be valid to these targets, got higher scores than the existing corresponding inhibitors after molecular docking, including ferulic acid, onjixanthone I and albiflorin. And the three molecules may refer to the singificant substances to the total compounds of HTRP which were effective to the disease.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1007/s12539-013-0056-1

  5 / 11750 MEDLINE  
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[PMID]: 25189111
[Au] Autor:Jia CX; Wang LL; Xu AQ; Dai AY; Qin P
[Ad] Address:School of Public Health, Shandong University, Jinan, China Center for Suicide Prevention and Research, Shandong University, Jinan, China...
[Ti] Title:Physical illness and suicide risk in rural residents of contemporary china.
[So] Source:Crisis;35(5):330-7, 2014 Jan 1.
[Is] ISSN:0227-5910
[Cp] Country of publication:Canada
[La] Language:eng
[Ab] Abstract:BACKGROUND: Physical illness is linked with an increased risk of suicide; however, evidence from China is limited. AIMS: To assess the influence of physical illness on risk of suicide among rural residents of China, and to examine the differences in the characteristics of people completing suicide with physical illness from those without physical illness. METHOD: In all, 200 suicide cases and 200 control subjects, 1:1 pair-matched on sex and age, were included from 25 townships of three randomly selected counties in Shandong Province, China. One informant for each suicide or control subject was interviewed to collect data on the physical health condition and psychological and sociodemographic status. RESULTS: The prevalence of physical illness in suicide cases (63.0%) was significantly higher than that in paired controls (41.0%; χ2 = 19.39, p < .001). Compared with suicide cases without physical illness, people who were physically ill and completed suicide were generally older, less educated, had lower family income, and reported a mental disorder less often. Physical illness denoted a significant risk factor for suicide with an associated odds ratio of 3.23 (95% CI: 1.85-5.62) after adjusted for important covariates. The elevated risk of suicide increased progressively with the number of comorbid illnesses. Cancer, stroke, and a group of illnesses comprising dementia, hemiplegia, and encephalatrophy had a particularly strong effect among the commonly reported diagnoses in this study population. CONCLUSION: Physical illness is an important risk factor for suicide in rural residents of China. Efforts for suicide prevention are needed and should be integrated with national strategies of health care in rural China.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1410
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1027/0227-5910/a000271

  6 / 11750 MEDLINE  
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[PMID]: 25027011
[Au] Autor:Breitenfeld T; Jurasic MJ; Breitenfeld D
[Ad] Address:Sestre milosrdnice (Sisters of Charity) Clinical Hospital Centre, University Department of Neurology, Vinogradska c. 29, 10 000, Zagreb, Croatia, tomislav.breitenfeld@zg.t-com.hr.
[Ti] Title:Hippocrates: the forefather of neurology.
[So] Source:Neurol Sci;35(9):1349-52, 2014 Sep.
[Is] ISSN:1590-3478
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:Hippocrates is one of the most influential medical doctors of all times. He started observing and experimenting in times of mysticism and magic. He carried a holistic and humanitarian approach to the patient with examination as the principal approach-inspection, palpation and auscultation are still the most important tools in diagnosing algorithms of today. He had immense experience with the human body most likely due to numerous wound treatments he had performed; some even believe he performed autopsies despite the negative trend at the time. Hippocrates identified the brain as the analyst of the outside world, the interpreter of consciousness and the center of intelligence and willpower. Interestingly, Hippocrates was aware of many valid concepts in neurology; his treatise On the Sacred Disease was the most important for understanding neurology and epilepsy. His other ideas pioneered modern day neurology mentioning neurological diseases like apoplexy, spondylitis, hemiplegia, and paraplegia. Today, 10 % of neurological Pubmed and 7 % of neuroscience Scopus reviews mention Corpus Hippocraticum as one of the sources. Therefore, Hippocrates may be considered as the forefather of neurology.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1007/s10072-014-1869-3

  7 / 11750 MEDLINE  
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[PMID]: 24582515
[Au] Autor:Zissimopoulos A; Stine R; Fatone S; Gard S
[Ad] Address:Northwestern University Prosthetics-Orthotics Center, Department of Physical Medicine & Rehabilitation, Feinberg School of Medicine, Chicago, IL, USA; Northwestern University, Department of Biomedical Engineering, Evanston, IL, USA. Electronic address: kikiz@u.northwestern.edu....
[Ti] Title:Mediolateral foot placement ability during ambulation in individuals with chronic post-stroke hemiplegia.
[So] Source:Gait Posture;39(4):1097-102, 2014 Apr.
[Is] ISSN:1879-2219
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Mediolateral (ML) foot placement is an effective way to redirect the lateral trajectory of the body center of mass (BCoM) during ambulation, but has only been partly characterized in the chronic post-stroke population despite their increased risk for falling [1]. During able-bodied gait, the locomotor system coordinates lower limb swing phase kinematics such that an appropriate ML foot placement occurs upon foot contact. Muscle weakness and abnormal motor patterns may impair foot placement ability post-stroke. The purpose of this study was to characterize ML foot placement ability during post-stroke ambulation by quantifying ML foot placement accuracy and precision, for the both sound and affected feet. Age matched able-bodied individuals were recruited for comparison. All participants were instructed to target step widths ranging from 0 to 45% leg length, as marked on the laboratory floor. Results of this study confirmed that ML foot placement accuracy and precision were significantly lower for the post-stroke group as compared to the control group (p=0.0). However, ML foot placement accuracy and precision were not significantly different between the affected and sound limbs in the post-stroke group. The lowest accuracy for post-stroke subjects was observed at both extreme step width targets (0 and 45%). Future work should explore potential mechanisms underlying these findings such as abnormal motor coordination, lower limb muscle strength, and abnormal swing phase movement patterns.
[Mh] MeSH terms primary: Foot/physiopathology
Gait Disorders, Neurologic/physiopathology
Hemiplegia/physiopathology
Postural Balance/physiology
Stroke/physiopathology
[Mh] MeSH terms secundary: Adult
Analysis of Variance
Case-Control Studies
Female
Humans
Male
Middle Aged
Walking/physiology
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Entry month:1410
[Js] Journal subset:IM
[Da] Date of entry for processing:140401
[St] Status:MEDLINE

  8 / 11750 MEDLINE  
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[PMID]: 24373786
[Au] Autor:Artilheiro MC; Corrêa JC; Cimolin V; Lima MO; Galli M; de Godoy W; Lucareli PR
[Ad] Address:Department of Rehabilitation Science, Human Motion Analysis Laboratory, Universidade Nove de Julho, São Paulo, Brazil. Electronic address: artilheiro.m@gmail.com....
[Ti] Title:Three-dimensional analysis of performance of an upper limb functional task among adults with dyskinetic cerebral palsy.
[So] Source:Gait Posture;39(3):875-81, 2014 Mar.
[Is] ISSN:1879-2219
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Patients with dyskinetic cerebral palsy (DCP) experience considerable variability in their purposeful movements due to involuntary movements that contribute to functional impairment. Movement analyses can demonstrate how the movements involved in bringing a mug to the mouth are performed by patients with DCP. Sixteen adults with DCP (29.63±4.42 years) and eleven healthy adults (24.09±3.73 years) performed six consecutive movements of bringing a mug to the mouth using their dominant arm. The mug was placed at 75% of each subject's maximum reach. Kinematic data were captured by 10 cameras and processed using biomechanical software. Fifteen reflexive markers were placed on predetermined bony landmarks on the head, trunk and upper limbs. DCP adults required more time to perform the going (bringing the mug to the mouth), adjusting (simulating taking a drink) and returning (lowering the mug back to the table) phases, and their movements were less smooth than the controls, as indicated by the index of curvature, average jerk and number of movement units. The DCP adults took a longer time to complete the task than controls as indicated by the peak velocities, mean velocities and times to peak velocity. With respect to the angular parameters, DCP adults had a smaller range of motion for shoulder and elbow flexion and forearm pronation compared with the controls. The analysis of functional tasks represents an important measure for the evaluation of dyskinetic movements and permits the quantitative characterization of upper limb impairment in adults with DCP.
[Mh] MeSH terms primary: Cerebral Palsy/physiopathology
Movement/physiology
Psychomotor Performance/physiology
Upper Extremity/physiopathology
[Mh] MeSH terms secundary: Activities of Daily Living
Adult
Biomechanical Phenomena/physiology
Female
Hemiplegia/physiopathology
Humans
Male
Middle Aged
Range of Motion, Articular/physiology
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1410
[Js] Journal subset:IM
[Da] Date of entry for processing:140318
[St] Status:MEDLINE

  9 / 11750 MEDLINE  
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[PMID]: 25056583
[Au] Autor:Rosewich H; Weise D; Ohlenbusch A; Gärtner J; Brockmann K
[Ad] Address:From the Interdisciplinary Pediatric Center for Children with Developmental Disabilities and Severe Chronic Disorders and the Division of Pediatric Neurology, Department of Pediatrics and Adolescent Medicine, University Medical Center Göttingen, Georg August University, Germany....
[Ti] Title:Phenotypic overlap of alternating hemiplegia of childhood and CAPOS syndrome.
[So] Source:Neurology;83(9):861-3, 2014 Aug 26.
[Is] ISSN:1526-632X
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:AIM; IM
[St] Status:In-Process
[do] DOI:10.1212/WNL.0000000000000735

  10 / 11750 MEDLINE  
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[PMID]: 24984692
[Au] Autor:Carty CP; Walsh HP; Gillett JG; Phillips T; Edwards JM; deLacy M; Boyd RN
[Ad] Address:Queensland Children's Gait Laboratory, Royal Children's Hospital, Brisbane, Australia; Centre for Musculoskeletal Research, Griffith Health Institute and School of Allied Health Sciences, Griffith University, Gold Coast, Australia. Electronic address: Christopher_carty@health.qld.gov.au....
[Ti] Title:The effect of femoral derotation osteotomy on transverse plane hip and pelvic kinematics in children with cerebral palsy: a systematic review and meta-analysis.
[So] Source:Gait Posture;40(3):333-40, 2014 Jul.
[Is] ISSN:1879-2219
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The purpose of this study was to systematically review the current literature to determine the effect of a femoral derotation osteotomy (FDRO) on hip and pelvic rotation kinematics during gait compared to no intervention in children with spastic cerebral palsy (CP). We performed a systematic search for prospective and retrospective cohort studies of children with CP, who were treated with a FDRO, and were assessed with pre and post surgery three-dimensional gait analysis. Medline, CINAHL, EMBASE, the Cochrane Library and Web of Science were searched up to December 2013. Data sources were prospective and retrospective studies. Mean differences were calculated on pooled data for both pelvic and hip rotation kinematics. Thirteen of 196 articles met the inclusion criteria (5 prospective, 8 retrospective). All included studies were of sufficient quality for meta-analysis as assessed using a customised version of the STROBE checklist. Meta-analysis showed that FDRO significantly reduced pelvic retraction by 9.0 degrees and hip internal rotation by 17.6 degrees in participants with unilateral CP involvement and hip internal rotation by 14.3 degrees in participants with bilateral CP involvement. Pelvic symmetry in children with unilateral spastic CP is significantly improved by FDRO. Patients with bilateral involvement do not improve their transverse plane pelvic rotation profiles during gait as a result to FDRO, although this result should be interpreted with caution due to the heterogeneous nature of these participants and of the methods used in the studies assessed.
[Mh] MeSH terms primary: Cerebral Palsy/surgery
Femur/surgery
Gait/physiology
Hemiplegia/surgery
Hip/surgery
Osteotomy/methods
[Mh] MeSH terms secundary: Biomechanical Phenomena
Cerebral Palsy/physiopathology
Child
Femur/physiopathology
Hemiplegia/physiopathology
Hip/physiopathology
Hip Joint/physiopathology
Hip Joint/surgery
Humans
Rotation
[Pt] Publication type:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Entry month:1410
[Js] Journal subset:IM
[Da] Date of entry for processing:140714
[St] Status:MEDLINE


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