Database : MEDLINE
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[PMID]: 29520810
[Au] Autor:Underbjerg L; Sikjaer T; Rejnmark L
[Ad] Address:Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Tage-Hansens Gade, Denmark.
[Ti] Title:Health-Related Quality of Life in patients with Non-Surgical Hypoparathyroidism and Pseudohypoparathyroidism.
[So] Source:Clin Endocrinol (Oxf);, 2018 Mar 09.
[Is] ISSN:1365-2265
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Non-surgical hypoparathyroidism (NS-HypoPT) and pseudohypoparathyroidism (PHP) are rare diseases, with a prevalence of 2/100.000 and 1/100.000, respectively. Only few studies on Quality of Life (QoL) among patients with Ns-HypoPT and PHP are available. We aimed to investigate the QoL among patients with Ns-HypoPT and PHP including information about education. DESIGN: A cohort study with patients identified from a previously epidemiological study. PATIENTS: 57 patients with Ns-HypoPT and 30 patients with PHP. MEASUREMENTS: The well-validated questionnaires SF-36v2 and WHO-5 Well Being Index. Results compared to norm-based material, disease specific norm-based material and patients with post-surgical HypoPT RESULTS: SF36v2 showed a significantly reduced score in all eight subdomains in patients with NS-HypoPT compared to a norm-based population. PHP patients scored lower in five subdomains. Females were more affected than males. Compared with post-surgical HypoPT, Ns-HypoPT and PHP are compatible at most domains. At the domains Physical Function, Social Function and Mental Health, Ns-HypoPT and PHP patients scored significantly lower (p <0.05). At the Mental Component Score, patients with Ns-HypoPT, had a lower score compared with post-surgical HypoPT (p<0.01). The overall WHO-5 Well Being Index score was comparable between groups (p=0.45). No differences were seen comparing patients with post-surgical HypoPT and Ns-HypoPT (p=0.68) or post-surgical HypoPT and PHP (p=0.67). A WHO-5 score below 28 indicates depression (NS-HypoPT=7; PHP=3, p=0.71), whereas a score between 28-50 suggesting poor emotional well-being (NS-HypoPT=19; PHP=5, p=0.13). The remaining patients scored above 50 suggesting well-being. CONCLUSION: QoL is impaired equally among patients with Ns-HypoPT and PHP. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1111/cen.13593

  2 / 5981 MEDLINE  
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[PMID]: 29516386
[Au] Autor:Meola A; Vignali E; Matrone A; Cetani F; Marcocci C
[Ad] Address:Department of Clinical and Internal Medicine, University of Pisa, Via Paradisa 2, 56127, Pisa, Italy.
[Ti] Title:Efficacy and safety of long-term management of patients with chronic post-surgical hypoparathyroidism.
[So] Source:J Endocrinol Invest;, 2018 Mar 07.
[Is] ISSN:1720-8386
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:PURPOSE: To evaluate adherence to European Society of Endocrinology guidelines and risk of renal complications in patients with chronic post-operative hypoparathyroidism (PO-HypoPT) treated with calcium and activated vitamin D metabolites. METHODS: We evaluated 90 adult patients (68 females and 22 males) with chronic (3 years) PO-HypoPT. Total albumin-corrected (Alb-Ca) and ionized serum calcium, phosphate, creatinine, PTH, and 24-h urinary calcium were measured; renal ultrasound was also performed. Healthy hospital employers (n = 142) were used as control. RESULTS: Complete data were available in 82 patients. Twenty-eight (34.1%) met four targets (Alb-Ca, phosphate, calcium phosphate product and 24-h urinary calcium), 36 (43.9%) three, 17 (20.7%) two, and 1 (1.2%) one. Thirteen (14.4%) had Alb-Ca value below and 18 (20.0%) above the target range and 54.9% 24-h urinary calcium above the upper normal limit. Seven (7.7%) has increased serum phosphate and none an increased calcium phosphate product. Eleven (12.2%) patients had eGFR < 60 mL/min × 1.73 m . Nephrolithiasis was present in 27 (30%) patients. Compared with the controls, patients had lower Alb-Ca (8.9 ± 0.5 vs. 9.5 ± 0.3 mg/dL, P 0.0001) and a higher rate of kidney stones, mostly asymptomatic [27/90 (30%) vs 7/142 (5%), P < 0.0001, odd ratio 8.2 (3.4-19.9)]. Fifty-seven patients had ≥ four serum Ca determinations during follow-up. Forty (70.2) patients had values within the target range in > 50% of cases, 18 in > 75%, and only 2 in 100%. Two patients never had values in the target range. CONCLUSIONS: Treatment of chronic PO-HypoPT with calcium and activated vitamin D metabolites is suboptimal and associated with an increased risk of renal complications.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1007/s40618-018-0857-5

  3 / 5981 MEDLINE  
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[PMID]: 29516129
[Au] Autor:Cianferotti L; Parri S; Gronchi G; Marcucci G; Cipriani C; Pepe J; Raglianti M; Minisola S; Brandi ML
[Ad] Address:Metabolic Bone Diseases Unit, Department of Surgery and Translational Medicine, University of Florence, Viale Pieraccini, 6, 50139, Florence, Italy.
[Ti] Title:Prevalence of Chronic Hypoparathyroidism in a Mediterranean Region as Estimated by the Analysis of Anonymous Healthcare Database.
[So] Source:Calcif Tissue Int;, 2018 Mar 08.
[Is] ISSN:1432-0827
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Epidemiological data on prevalence and incidence of chronic hypoparathyroidism are still scarce. This study aimed to establish prevalence of chronic hypoparathyroidism and incidence of surgical hypoparathyroidism using the analysis of electronic anonymous public health care database. Data referred to a 5-year period (2009-2013, Region of Tuscany, Italy, as a sample representative of the whole Mediterranean/European population, estimated mean population: 3,750,000 inhabitants) were retrieved by the analysis of pharmaceutical distribution dataset, containing data related to drugs reimbursed by public health system, hospital discharge and procedures codes, and ICD9 exemption codes for chronic diseases. The application of a specific algorithm was applied to indirectly identify people with chronic hypoparathyroidism as assuming chronic therapy with active vitamin D metabolites (AVDM). The number of people taking AVDM for a period equal to or longer than 6 months till the end of the study period, with ICD9 exemption code for hypoparathyroidism, and with a disease-related discharge code were identified. Within this restricted group, patients with chronic kidney disease and osteoporosis were excluded. The indirect estimate of chronic hypoparathyroidism in a European Mediterranean subpopulation by means of the analysis of chronic therapy with AVDM was 27/100,000 inhabitants (female:male ratio = 2.2:1), with a mean age of 63.5 ± 16.7 years. The risk of developing hypoparathyroidism after neck surgery was 1.5%. While the epidemiological approaches based on disease code and hospital discharge code greatly underestimates the prevalence of hypoparathyroidism, the indirect estimate of this disease through the analysis of prescriptions of AVDM in a European region is in line with the results of studies performed in other regions of the world.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1007/s00223-018-0405-5

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[PMID]: 29489687
[Au] Autor:Li L; Yang H; Li J; Yu Y; Wang F; Zhu X; Liu G
[Ad] Address:Department of Neurology, PLA 44 Hospital.
[Ti] Title:Misdiagnosis of idiopathic hypoparathyroidism: A case report and literature review.
[So] Source:Medicine (Baltimore);97(9):e9884, 2018 Mar.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Idiopathic hypoparathyroidism (IHP) is a rare endocrine condition, which is frequently represented by neuropsychiatric disorders. Hence, the misdiagnosis rate of the disease is rather high, especially for neurologists. PATIENT CONCERNS: We reported a case of misdiagnosed, atypical IHP. In addition, the literature on IHP and the misdiagnosis published in China in the past 2 decades has been reviewed and summarized. DIAGNOSES: Blood testing confirmed that parathyroid hormone (PTH) = 0 pg/mL and the final diagnosis was IHP. INTERVENTIONS AND OUTCOMES: With calcium and vitamin D supplementation, the patient's myasthenia improved significantly, and muscle enzymes returned to normal gradually. One-year follow-up demonstrated that the patient's myasthenia disappeared, and the blood calcium and PTH levels were normal. In addition, the literature on IHP and the misdiagnosis published in China in the past 2 decades has been reviewed and summarized. LESSONS: The misdiagnosis rate of IHP in China was high in the past 2 decades, which might be attributed to the misdiagnosis as epilepsy or mental diseases. A clinician should be able to understand the disease and emphasize the screening of high-risk population, especially for those patients with hypocalcemia, hyperphosphatemia, and increased blood creatine kinase with unknown causes or nontypical clinical symptoms.
[Mh] MeSH terms primary: Diagnostic Errors/adverse effects
Hypoparathyroidism/diagnosis
[Mh] MeSH terms secundary: Adult
Female
Humans
Hypoparathyroidism/drug therapy
Parathyroid Hormone/blood
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Parathyroid Hormone)
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180301
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009884

  5 / 5981 MEDLINE  
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[PMID]: 29512348
[Au] Autor:Serpell JW
[Ad] Address:Specialist Centre, Melbourne, Victoria, Australia.
[Ti] Title:Preventing hypoparathyroidism after total thyroidectomy.
[So] Source:ANZ J Surg;88(3):127-128, 2018 Mar.
[Is] ISSN:1445-2197
[Cp] Country of publication:Australia
[La] Language:eng
[Pt] Publication type:EDITORIAL
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Data-Review
[do] DOI:10.1111/ans.14235

  6 / 5981 MEDLINE  
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[PMID]: 29511787
[Au] Autor:Marcucci G; Cianferotti L; Parri S; Altieri P; Arvat E; Benvenga S; Betterle C; Bondanelli M; Boscaro M; Camozzi V; Centaro GM; Cetani F; Chiodini I; Ciampolillo A; Colao A; Corbetta S; De Feo ML; Uberti ED; Faggiano A; Fornari R; Gaspari AL; Giorgino F; Giuliani V; Iacobone M; Innaro N; Lamacchia O; Lenzi A; Mantovani G; Marcocci C; Masi L; Migliaccio S; Palmieri S; Pasquali R; Perigli G; Piccini V; Romagnoli E; Ruggeri RM; Rulli F; Samà MT; Tomaino G; Trimarchi F; Zatelli MC; Brandi ML
[Ad] Address:Bone Metabolic Diseases Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.
[Ti] Title:HypoparaNet: A Database of Chronic Hypoparathyroidism Based on Expert Medical-Surgical Centers in Italy.
[So] Source:Calcif Tissue Int;, 2018 Mar 06.
[Is] ISSN:1432-0827
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Hypoparathyroidism is a rare disease characterized by low serum calcium levels and absent or deficient parathyroid hormone level. Regarding the epidemiology of chronic hypoparathyroidism, there are limited data in Italy and worldwide. Therefore, the purpose of this study was to build a unique database of patients with chronic hypoparathyroidism, derived from the databases of 16 referral centers for endocrinological diseases, affiliated with the Italian Society of Endocrinology, and four centers for endocrine surgery with expertise in hypoparathyroidism, to conduct an epidemiological analysis of chronic hypoparathyroidism in Italy. The study was approved by the Institutional Review Board. A total of 537 patients with chronic hypoparathyroidism were identified. The leading etiology was represented by postsurgical hypoparathyroidism (67.6%), followed by idiopathic hypoparathyroidism (14.6%), syndromic forms of genetic hypoparathyroidism (11%), forms of defective PTH action (5.2%), non-syndromic forms of genetic hypoparathyroidism (0.9%), and, finally, other forms of acquired hypoparathyroidism, due to infiltrative diseases, copper or iron overload, or ionizing radiation exposure (0.7%). This study represents one of the first large-scale epidemiological assessments of chronic hypoparathyroidism based on data collected at medical and/or surgical centers with expertise in hypoparathyroidism in Italy. Although the study presents some limitations, it introduces the possibility of a large-scale national survey, with the final aim of defining not only the prevalence of chronic hypoparathyroidism in Italy, but also standards for clinical and therapeutic approaches.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:Publisher
[do] DOI:10.1007/s00223-018-0411-7

  7 / 5981 MEDLINE  
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[PMID]: 29369600
[Au] Autor:Marcinkowska M; Sniecikowska B; Zygmunt A; Brzezinski J; Dedecjus M; Lewinski A
[Ad] Address:Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland.
[Ti] Title:Postoperative hypoparathyroidism in patients after total thyroidectomy - retrospective analysis.
[So] Source:Neuro Endocrinol Lett;38(7):488-494, 2017 Dec.
[Is] ISSN:0172-780X
[Cp] Country of publication:Sweden
[La] Language:eng
[Ab] Abstract:OBJECTIVES: Hypoparathyroidism is the most frequent complication of thyroidectomy. The incidence rates of temporary and permanent postoperative hypoparathyroidism vary from 7 to more than 60% and from 0 to 9%, respectively. DESIGN: The aim of the study has been to evaluate the incidence of hypoparathyroidism and clinical manifestations of hypocalcaemia after total thyroidectomy, as well as assess factors that affect the frequency of the symptomatic hypocalcaemia, and benefits resulting from the measurement of parathyroid hormone (PTH) concentration on the first day after thyroidectomy. SETTING: The studied group consisted of 330 patients after total thyroidectomy, while the control group consisted of 86 patients who underwent total resection of one lobe only or subtotal thyroidectomy. RESULTS: Based on the measurements of serum PTH concentration on the first day after total thyroidectomy, postoperative hypoparathyroidism was diagnosed in 48% of patients. After total thyroidectomy, the frequency of clinical symptoms of hypocalcaemia was twice less than the incidence of hypoparathyroidism confirmed by biochemical testing. Total thyroidectomy occurred to be an independent factor of the increased risk of postoperative hypoparathyroidism. This risk was even higher in the cases widened by lymphadenectomy, and among patients with Graves' disease. In the group of patients with decreased serum PTH concentration the occurrence of clinical symptoms of hypocalcaemia significantly depended on serum PTH concentration - patients with lower PTH levels reported paresthesias more frequently. CONCLUSIONS: Serum PTH levels below 5 pg/ml seems to be a good prognostic factor of the occurrence of hypocalcaemia symptoms. The information about low PTH concentration allows to start the pharmacotherapy faster and avoid clinical manifestation of hypocalcaemia.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:In-Data-Review

  8 / 5981 MEDLINE  
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[PMID]: 29398643
[Au] Autor:Gogorza MS; Mena E; Serra G; Jiménez A; Noval M; Pereg V
[Ad] Address:Servicio de Endocrinología y Nutrición, Hospital Universitari Son Espases, Palma, Illes Balears, España. Electronic address: msgogorza@gmail.com.
[Ti] Title:Síndrome hypoparathyroidism-deafness-renal dysplasia: descripción de un caso. The hypoparathyroidism-deafness-renal dysplasia syndrome: A case report.
[So] Source:Endocrinol Diabetes Nutr;65(3):187-188, 2018 Mar.
[Is] ISSN:2530-0172
[Cp] Country of publication:Spain
[La] Language:eng; spa
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180304
[Lr] Last revision date:180304
[St] Status:In-Data-Review

  9 / 5981 MEDLINE  
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[PMID]: 29494340
[Au] Autor:Ajarmeh SA; Al Tamimi EM
[Ad] Address:Department of Pediatrics, Faculty of Medicine, Mutah University, 61710 Karak, Jordan.
[Ti] Title:Sanjad-Sakati syndrome with macrocytic anemia and failure to thrive: a case from South Jordan.
[So] Source:J Pediatr Endocrinol Metab;, 2018 Mar 01.
[Is] ISSN:2191-0251
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Backgorund: Sanjad-Sakati syndrome (SSS) is a rare autosomal recessive disease caused by a deletion mutation (155-166del) in exon 3 of the TBCE gene on chromosome 1q42-43. The syndrome is characterized by primary hypoparathyroidism, typical dysmorphic features and severe growth retardation. CASE PRESENTATION: We encountered a 2-year-old boy with hypocalcemia, failure to thrive and macrocytic anemia. The patient had the characteristic features of SSS and genetic testing confirmed that he was homozygous for the TBCE mutation. Although malabsorption was initially considered the cause of his symptoms, the results did not confirm that diagnosis. Our patient had cow milk protein allergy and folic acid deficiency, which has not been described in previous SSS cases. It was difficult to treat the patient's hyperphosphatemia and we ultimately selected sevelamer treatment, which was tolerated well and improved his hypocalcemia. CONCLUSIONS: SSS should be considered in the differential diagnosis of any infant with hypocalcemia, dysmorphism and failure to thrive.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[St] Status:Publisher

  10 / 5981 MEDLINE  
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[PMID]: 29405252
[Au] Autor:Vidal Fortuny J; Sadowski SM; Belfontali V; Guigard S; Poncet A; Ris F; Karenovics W; Triponez F
[Ad] Address:Department of Thoracic and Endocrine Surgery and Faculty of Medicine, University Hospitals of Geneva, Geneva, Switzerland.
[Ti] Title:Randomized clinical trial of intraoperative parathyroid gland angiography with indocyanine green fluorescence predicting parathyroid function after thyroid surgery.
[So] Source:Br J Surg;105(4):350-357, 2018 Mar.
[Is] ISSN:1365-2168
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Hypoparathyroidism, the most common complication after thyroid surgery, leads to hypocalcaemia and significant medical problems. An RCT was undertaken to determine whether intraoperative parathyroid gland angiography with indocyanine green (ICG) could predict postoperative hypoparathyroidism, and obviate the need for systematic blood tests and oral calcium supplementation. METHODS: Between September 2014 and February 2016, patients who had at least one well perfused parathyroid gland on ICG angiography were randomized to receive standard follow-up (measurement of calcium and parathyroid hormone (PTH) on postoperative day (POD) 1 and systematic supplementation with calcium and vitamin D; control group) or no supplementation and no blood test on POD 1 (intervention group). In all patients, calcium and PTH levels were measured 10-15 days after thyroidectomy. The primary endpoint was hypocalcaemia on POD 10-15. RESULTS: A total of 196 patients underwent ICG angiography during thyroid surgery, of whom 146 had at least one well perfused parathyroid gland on ICG angiography and were randomized. None of these patients presented with hypoparathyroidism, including those who did not receive calcium supplementation. The intervention group was statistically non-inferior to the control group (exact 95 per cent c.i. of the difference in proportion of patients with hypocalcaemia -0·053 to 0·053; P = 0·012). Eleven of the 50 excluded patients, in whom no well perfused parathyroid gland could be identified by angiography, presented with hypoparathyroidism on POD 1, and six on POD 10-15, which was significantly different from the findings in randomized patients (P = 0·007). CONCLUSION: ICG angiography reliably predicts the vascularization of the parathyroid glands and obviates the need for postoperative measurement of calcium and PTH, and supplementation with calcium in patients with at least one well perfused parathyroid gland. Registration number: NCT02249780 (http://www.clinicaltrials.gov).
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[Cl] Clinical Trial:ClinicalTrial
[St] Status:In-Data-Review
[do] DOI:10.1002/bjs.10783


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