Database : MEDLINE
Search on : Hypopharyngeal and Neoplasms [Words]
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[PMID]: 29365378
[Au] Autor:Zhang HD; Gong SC; Liu YQ; Liang LJ; He SB; Zhang QX; Si MY; Yu ZK
[Ad] Address:Department of Otorhinolaryngology and Head and Neck Surgery, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing 211100, China.
[Ti] Title:[The significance of circulating tumor cells in head and neck squamous cell carcinoma: a preliminary study].
[So] Source:Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;53(1):39-44, 2018 Jan 07.
[Is] ISSN:1673-0860
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:To investigate the significance of circulating tumor cells (CTC) in squamous cell carcinoma of the head and neck (HNSCC). Twenty-four patients with HNSCC treated between October 2016 and July 2017 in our department were selected (experimental group), including 23 males and 1 females, aged 47-81 years. There were 14 cases of squamous cell carcinoma of larynx and 10 cases of hypopharynx, including I-Ⅱ stage (5 cases) and Ⅲ- Ⅳ stage (19 cases). All patients were primary and/or relapsed after treatment. Nine healthy volunteers were selected as control group. A novel capture technique (CellCellector system) was used to detect CTC. SPSS23.0 was used for statistical analysis. The total capture rate of CTC in patients with HNSCC before treatment was 70.8% (17/24), with 40% (2/5) for patients at I-Ⅱ stage, and 78.9% (15/19) for patients at Ⅲ- Ⅳ stage, and was 0 in patients of control group. The total capture rate of CTC in patients with HNSCC after treatment was 50% (8/16). There was no significant correlation between CTC and age, sex, location of tumor or lymph node metastasis ( >0.05). CTC was related to tumor staging and tumor differentiation ( <0.05). The positive rate of EGFRVⅢ in CTC was 26.3% (5/19). The CellCollector system is a very efficient way of detecting CTC, and CTC plays an important role in the occurrence, progression and metastasis of HNSCC.
[Mh] MeSH terms primary: Carcinoma, Squamous Cell/secondary
Hypopharyngeal Neoplasms/pathology
Laryngeal Neoplasms/pathology
Neoplastic Cells, Circulating
[Mh] MeSH terms secundary: Aged
Aged, 80 and over
Carcinoma, Squamous Cell/chemistry
Carcinoma, Squamous Cell/pathology
Case-Control Studies
Cell Count
Female
Humans
Hypopharyngeal Neoplasms/chemistry
Laryngeal Neoplasms/chemistry
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Staging
Neoplastic Cells, Circulating/chemistry
Neoplastic Cells, Circulating/pathology
Receptor, Epidermal Growth Factor/analysis
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (epidermal growth factor receptor VIII); EC 2.7.10.1 (Receptor, Epidermal Growth Factor)
[Em] Entry month:1802
[Cu] Class update date: 180215
[Lr] Last revision date:180215
[Js] Journal subset:IM
[Da] Date of entry for processing:180125
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1673-0860.2018.01.008

  2 / 3647 MEDLINE  
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[PMID]: 29365374
[Au] Autor:Wen YH; Wen WP; Wang ZF; Zhu XL; Jiang AY; Chai LP; Lei WB
[Ad] Address:Otorhinolaryngology Hospital, the First Affliated Hospital of Sun Yatsen University, Guangzhou Key Laboratory of Otorhinolaryngology, Guangzhou 510080, China.
[Ti] Title:[Clinical application of supraclavicular flap for oncologic reconstruction of hypopharynx and upper esophagus].
[So] Source:Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;53(1):16-20, 2018 Jan 07.
[Is] ISSN:1673-0860
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:To assess the efficacy of supraclavicular artery island flap (SCAIF) for the reconstruction of hypopharynx and upper esophagus. The SCAIF procedure on was used in 10 patients, including 8 with hypopharygeal carcinomas, 1 with esophageal carcinoma and neck skin invasion and 1 with hypopharyngeal leiomyosarcoma, at the Otorhinolaryngology Hospital, the First Affiliated Hospital, Sun Yatsen University between December 2015 and June 2017. The sizes of the flaps were measured in (4-8) cm(5-12) cm. Clinical indexes such as harvesting time and survival were recorded. Harvesting time for SCAIF ranged from 20 to 30 minutes, averaging 26 minutes. Nine flaps survived, one flap had partially necrosis. Functional outcomes were excellent and the donor sites were direct closed without complications. SCAIF is a versatile, reliable, and easily harvested flap, with good cosmetic and functional outcomes for reconstructing the defects of hypopharynx and upper esophagus.
[Mh] MeSH terms primary: Carcinoma/surgery
Esophageal Neoplasms/surgery
Esophagus/surgery
Hypopharyngeal Neoplasms/surgery
Hypopharynx/surgery
Reconstructive Surgical Procedures/methods
Surgical Flaps/transplantation
[Mh] MeSH terms secundary: Arteries
Humans
Leiomyosarcoma/surgery
Neck
Necrosis
Skin Neoplasms/surgery
Surgical Flaps/blood supply
Time Factors
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180215
[Lr] Last revision date:180215
[Js] Journal subset:IM
[Da] Date of entry for processing:180125
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1673-0860.2018.01.004

  3 / 3647 MEDLINE  
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[PMID]: 29443638
[Au] Autor:Chen W; Shimane T; Kawano S; Alshaikh A; Kim SY; Chung SH; Kim RH; Shin KH; Walentin K; Park NH; Schmidt-Ott KM; Kang MK
[Ad] Address:1 The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, USA.
[Ti] Title:Human Papillomavirus 16 E6 Induces FoxM1B in Oral Keratinocytes through GRHL2.
[So] Source:J Dent Res;:22034518756071, 2018 Feb 01.
[Is] ISSN:1544-0591
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:High-risk human papillomavirus (HPV) is a major risk factor for oral and pharyngeal cancers (OPCs), yet the detailed mechanisms by which HPV promotes OPCs are not understood. Forkhead box M1B (FoxM1B) is an oncogene essential for cell cycle progression and tumorigenesis, and it is aberrantly overexpressed in many tumors. We previously showed that FoxM1B was the putative target of an epithelial-specific transcription factor, Grainyhead-like 2 (GRHL2). In the current study, we demonstrate that HPV type 16 (HPV-16) E6 induces FoxM1B in human oral keratinocytes (HOKs) and tonsillar epithelial cells (TECs) in part through GRHL2. FoxM1B was barely detectable in cultured normal human oral keratinocytes (NHOKs) and progressively increased in immortalized HOKs harboring HPV-16 genome (HOK-16B) and tumorigenic HOK-16B/BaP-T cells. Retroviral expression of HPV-16 E6 and/or E7 in NHOKs, TECs, and hypopharyngeal carcinoma cells (FaDu) revealed induction of FoxM1B and GRHL2 by the E6 protein but not E7. Both GRHL2 and FoxM1B were strongly induced in the epidermis of HPV-16 E6 transgenic mice and HPV oral squamous cell carcinomas. Ectopic expression of FoxM1B led to acquisition of transformed phenotype in HOK-16B cells. Loss of FoxM1B by lentiviral short hairpin RNA vector or chemical inhibitor led to elimination of tumorigenic characteristics of HOK-16B/BaP-T cells. Luciferase reporter assay revealed that GRHL2 directly bound and regulated the FoxM1B gene promoter activity. Using epithelial-specific Grhl2 conditional knockout mice, we exposed wild-type (WT) and Grhl2 KO mice to 4-nitroquinolin 1-oxide (4-NQO), which led to induction of FoxM1B in the tongue tissues and rampant oral tumor development in the WT mice. However, 4-NQO exposure failed to induce tongue tumors or induction of FoxM1B expression in Grhl2 KO mice. Collectively, these results indicate that HPV-16 induces FoxM1B in part through GRHL2 transcriptional activity and that elevated FoxM1B level is required for oropharyngeal cancer development.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180214
[Lr] Last revision date:180214
[St] Status:Publisher
[do] DOI:10.1177/0022034518756071

  4 / 3647 MEDLINE  
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[PMID]: 29374693
[Au] Autor:Ernst BP; Mikstas C; Stver T; Stauber R; Strieth S
[Ad] Address:Department of Otorhinolaryngology, University Hospital Frankfurt, Frankfurt, Germany benjamin.ernst@unimedizin-mainz.de.
[Ti] Title:Association of eIF4E and SPARC Expression with Lymphangiogenesis and Lymph Node Metastasis in Hypopharyngeal Cancer.
[So] Source:Anticancer Res;38(2):699-706, 2018 02.
[Is] ISSN:1791-7530
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:BACKGROUND/AIM: Head and neck squamous cell carcinomas (HNSCC) are characterized by aggressiveness, early recurrence and lymph node metastasis. Therefore, there is an urgent need to identify new biomarkers and drug targets. MATERIALS AND METHODS: Neck dissection specimens from 11 patients diagnosed with hypopharyngeal cancer were analyzed for their lymphatic vessel density (LVD) by lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) immunostaining, expression of eukaryotic initiation factor 4E (eIF4E) and levels of secreted protein acidic and rich in cysteine (SPARC) using immunoblot analysis. RESULTS: Compared to lymph node biopsies of healthy controIs, LVD was significantly increased in metastatic lymph nodes as well as in advanced primary tumors. Overexpression of eIF4E and SPARC was demonstrated in all hypopharyngeal cancer specimens. Notably, we observed that increased LVD significantly correlated with the expression of eIF4E as well as SPARC levels. CONCLUSION: eIF4E- and SPARC-associated signaling pathways may be associated with lymphangiogenesis and could be exploited to counteract the spread of hypopharyngeal cancer cells.
[Mh] MeSH terms primary: Hypopharyngeal Neoplasms/metabolism
Hypopharyngeal Neoplasms/pathology
Lymphangiogenesis/physiology
Nucleocytoplasmic Transport Proteins/metabolism
Osteonectin/metabolism
[Mh] MeSH terms secundary: Biomarkers, Tumor/metabolism
Carcinoma, Squamous Cell/metabolism
Carcinoma, Squamous Cell/pathology
Female
Head and Neck Neoplasms/metabolism
Head and Neck Neoplasms/pathology
Humans
Lymph Nodes/metabolism
Lymph Nodes/pathology
Lymphatic Metastasis/pathology
Male
Middle Aged
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Biomarkers, Tumor); 0 (EIF4ENIF1 protein, human); 0 (Nucleocytoplasmic Transport Proteins); 0 (Osteonectin); 0 (SPARC protein, human)
[Em] Entry month:1802
[Cu] Class update date: 180208
[Lr] Last revision date:180208
[Js] Journal subset:IM
[Da] Date of entry for processing:180129
[St] Status:MEDLINE

  5 / 3647 MEDLINE  
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[PMID]: 29262511
[Au] Autor:Wang Q; Liu YH; Hu GQ; Wu KL; Tong BS; Gao CB; Zhao Y
[Ad] Address:Department of Otalaryngology and head surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
[Ti] Title:[Surgical management of elderly patients with medial wall pyriform sinus cancer].
[So] Source:Zhonghua Zhong Liu Za Zhi;39(12):931-936, 2017 Dec 23.
[Is] ISSN:0253-3766
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:To investigate the clinical efficacy of preoperative-, postoperative-radiotherapy and surgery for preserving laryngeal function in patient over 70 years of age with medial wall pyriform sinus cancer. Clinical data of 48 patients over 70 years of age with medial wall pyriform sinus cancer who received surgical treatment from January 2001 to December 2010 were retrospectively analyzed. Among them, 21 cases were given preoperative radiotherapy and surgery (R+ S). The radiation therapy dose was 45 Gy. And 14 cases' larynx is preserved. In addition, 27 cases were given postoperative radiotherapy and surgery (S+ R). The radiation therapy dose was 65 Gy. And 10 cases had preserved laryngeal function. Survival rates were analyzed by the Kaplan-Meier method. Chi-square test was used to compare complications between two groups. The larynx preservation rate in R+ S group [66.7% (14/21)] was significantly higher than that in S+ R group [37.0% (10/27), <0.05]. The complication rate and decannulation rate in R+ S group were 42.9% (9/21) and 64.3% (9/14), respectively, showing no difference compared with those in S+ R group [37.0% (10/27) and 50.0% (5/10), respectively] (all >0.05). The complication rates of patients with and without larynx preservation were 41.7% (10/24) and 37.5% (9/24), respectively, showing no difference between two groups ( >0.05). The overall 3-years and 5-years survival rates for all patients were 54.2% (26/48) and 35.4% (17/48), respectively. There was no significant difference in survival rates between R+ S [38.1% (8/21)] group and S+ R group [33.3% (9/27), >0.05)]. In the R+ S group, the survival rates in patients with and without larynx preservation were 40.0% (4/10) and 29.4% (5/17), respectively, showing no significant difference between two groups ( >0.05). It is secure and effective to choose the operation with laryngeal preservation for patient over 70 years of age with medial wall pyriform sinus cancer based on their physical conditions and the tumor extension. The preoperative- and postoperative-radiotherapy have the similar effect. Preoperative radiotherapy and surgery increases the laryngeal preservation rate.
[Mh] MeSH terms primary: Carcinoma, Squamous Cell/radiotherapy
Carcinoma, Squamous Cell/surgery
Hypopharyngeal Neoplasms/radiotherapy
Hypopharyngeal Neoplasms/surgery
Larynx
Organ Sparing Treatments
Pyriform Sinus/radiation effects
Pyriform Sinus/surgery
[Mh] MeSH terms secundary: Aged
Carcinoma, Squamous Cell/mortality
Humans
Laryngectomy
Radiotherapy Dosage
Retrospective Studies
Survival Rate
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180205
[Lr] Last revision date:180205
[Js] Journal subset:IM
[Da] Date of entry for processing:171221
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0253-3766.2017.12.010

  6 / 3647 MEDLINE  
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[PMID]: 29262512
[Au] Autor:Liu WZ; Li ZD; Li SC; Liu HW; Fang FQ; Xu CJ; Li YG
[Ad] Address:Department of Head and Neck Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, China.
[Ti] Title:[Study on the metastatic sequence of cervix lymph node in hypopharyngeal carcinoma].
[So] Source:Zhonghua Zhong Liu Za Zhi;39(12):937-941, 2017 Dec 23.
[Is] ISSN:0253-3766
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:To investigate the metastatic sequence of cervical lymph node in hypopharyngeal carcinoma aimed at guiding neck exploration. Seventy-five serial sections of integrally dissected lateral neck specimens from 67 patients of hypophayryngeal carcinoma were histopathologically observed, and the metastatic sequence of cervical lymph node of hypophayryngeal carcinoma were analysed. In 75 integrally dissected lateral neck specimens, 63 laterals were found to occur cervical lymph node metastases, the metastatic ratio was 84.0%. The analytic result of 63 dissected lateral neck specimens with positive lymph nodes showed that the metastatic lymph node ratio in descending order was level Ⅱ (90.5%), level Ⅲ (76.2%), level Ⅳ (41.3%), level Ⅴ (15.9%), level Ⅰ (7.9%) and level Ⅵ (3.2%). The metastatic ratio of lymph node between level Ⅰ~Ⅵ were significantly different from each other ( <0.01). When the tumor metastasized to one cervical lymph node, this could be found in levels Ⅱ or Ⅲ, when metastasized to two cervical lymph nodes, these could be found in levels Ⅱ, Ⅲ, Ⅳ, and when metastasized to more than 5 of cervical lymph nodes, these could be found in levels Ⅱ, Ⅲ, Ⅳ, Ⅴ, Ⅰand Ⅵ. According to the occurring sequence, metastatic ratio and number of cervical lymph node metastasis (LNM), levels Ⅱ and Ⅲ were identified as the first station, level Ⅳ was the second station and levels Ⅴ, Ⅰ and Ⅵ were the third station of cervical LNM in hypopharyngeal carcinoma. The confirmation of metastatic sequence of cervical lymph node in hypophayryngeal carcinoma provides a reliable evidence for neck lymph node dissection and reference value for clinic therapy.
[Mh] MeSH terms primary: Carcinoma/secondary
Hypopharyngeal Neoplasms/pathology
Lymph Nodes/pathology
Neck Dissection
[Mh] MeSH terms secundary: Carcinoma/surgery
Humans
Hypopharyngeal Neoplasms/surgery
Lymph Nodes/surgery
Lymphatic Metastasis
Neck
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180205
[Lr] Last revision date:180205
[Js] Journal subset:IM
[Da] Date of entry for processing:171221
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0253-3766.2017.12.011

  7 / 3647 MEDLINE  
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[PMID]: 27775879
[Au] Autor:Wang L; Mou Y; Meng D; Sun Y; Chen X; Yang X; Jia C; Song X; Li X
[Ad] Address:Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
[Ti] Title:MicroRNA-203 inhibits tumour growth and metastasis through PDPN.
[So] Source:Clin Otolaryngol;42(3):620-628, 2017 Jun.
[Is] ISSN:1749-4486
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: MicroRNAs play an important role in regulating hypopharyngeal cancer development. miR-203 has been previously shown to possess antitumour capabilities in many cancers, but not in hypopharyngeal cancer. DESIGN: Using human normal and hypopharyngeal cancer specimens, we explored the expression levels of miR-203 in the two groups and further correlated them with different stages of cancer and lymph node metastasis. SETTING AND PARTICIPANTS: Applying human pharynx FaDu cancer cells and lentiviral transduction technique, we investigated the effects of miR-203 on cancer cell viability, migration and invasion. Moreover, we studied the novel relationship between miR-203 and podoplanin (PDPN) in hypopharyngeal cancer. RESULTS: The downregulated levels of miR-203 in human hypopharyngeal cancer tissues were associated with advanced cancer stages and lymph node metastasis. High levels of miR-203 inhibited cell viability, migration and invasion of hypopharyngeal cancer cells. Further studies suggested miR-203 directly targeted and inhibited PDPN expression. PDPN silencing suppresses hypopharyngeal cancer cell abilities. In addition, PDPN overexpression was able to reverse miR-203 inhibitory effects on cell viability, migration and invasion. CONCLUSION: PDPN acts as an oncogene to promote hypopharyngeal cancer cell viability, migration and invasion. miR-203 directly targets PDPN to suppress its expression, thus exerting inhibitory effects on cancer metastasis.
[Mh] MeSH terms primary: Carcinoma, Squamous Cell/genetics
Down-Regulation
Gene Expression Regulation, Neoplastic
Hypopharyngeal Neoplasms/genetics
Membrane Glycoproteins/genetics
MicroRNAs/genetics
RNA, Neoplasm/genetics
[Mh] MeSH terms secundary: Blotting, Western
Carcinoma, Squamous Cell/metabolism
Carcinoma, Squamous Cell/secondary
Cell Movement
Cell Survival
Humans
Hypopharyngeal Neoplasms/metabolism
Hypopharyngeal Neoplasms/pathology
Lymphatic Metastasis
Membrane Glycoproteins/biosynthesis
MicroRNAs/biosynthesis
Neoplasm Invasiveness/genetics
Neoplasm Invasiveness/pathology
Real-Time Polymerase Chain Reaction
Tumor Cells, Cultured
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (MIRN203 microRNA, human); 0 (Membrane Glycoproteins); 0 (MicroRNAs); 0 (PDPN protein, human); 0 (RNA, Neoplasm)
[Em] Entry month:1801
[Cu] Class update date: 180126
[Lr] Last revision date:180126
[Js] Journal subset:IM
[Da] Date of entry for processing:161025
[St] Status:MEDLINE
[do] DOI:10.1111/coa.12785

  8 / 3647 MEDLINE  
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[PMID]: 29245340
[Au] Autor:Su CL; Chang GH; Fang KH; Chang CC
[Ad] Address:aDepartment of Surgery, Chang Gung Memorial Hospital, Linkou, TaoyuanbDepartment of Otolaryngology-Head and Neck SurgerycCenter of Excellence for Chang Gung Research Datalink, Chang Gung Memorial Hospital, ChiayidDepartment of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou, TaoyuaneDivision of Plastic and Reconstructive Surgery, Department of Surgery, China Medical University HospitalfSchool of medicine, College of Medicine, China Medical University, TaichunggInstitute of Imaging and Biomedical Photonics, National Chiao Tung University, Tainan, Taiwan.
[Ti] Title:Successful salvage for the intractable massive chylous leakage in a cirrhotic patient: A case report and literature review.
[So] Source:Medicine (Baltimore);96(49):e9103, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Iatrogenic chylous leakage (CL) is a rare but potentially life-threatening complication after neck surgery. In cirrhotic patient, the massive CL is even more intractable and extremely dangerous due to portal hypertension. PATIENTS CONCERNS: A 54-year-old liver cirrhotic patient had milky fluid leakage from left neck drainage tube after neck dissection surgery and hypopharyngeal cancer ablation. Electrolyte imbalance and shock status were reported when conservative managements and exploratory surgical repair failed to terminate the leakage. DIAGNOSIS: Massive CL up to >5 L/day was recorded on the post-operative day (POD) 9. INTERVENTIONS: A triangular-shaped pectoralis major (PM) muscle was designed to repair the lymph nodes dissected defect over left neck. OUTCOMES: After surgery, CL dramatically reduced to less than 300 mL/day in the coming day without relapses and terminated on the 8th days. After 3 months, the wound completely healed and the food conduit passage was patent without fistula. LESSONS: This report demonstrated the superiority of pectoralis major myocutaneous flap (PMMF) than the conservative treatment, local muscle flap, and radiologic or thoracoscopic duct ligation in cirrhotic patient with massive CL.
[Mh] MeSH terms primary: Chyle
Liver Cirrhosis/complications
Neck Dissection/adverse effects
Postoperative Complications/surgery
[Mh] MeSH terms secundary: Catheter Ablation
Humans
Hypopharyngeal Neoplasms/surgery
Male
Middle Aged
Pectoralis Muscles/transplantation
Shock/complications
Surgical Flaps
Water-Electrolyte Balance
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180105
[Lr] Last revision date:180105
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009103

  9 / 3647 MEDLINE  
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[PMID]: 29284434
[Au] Autor:Kim SY; Rho YS; Choi EC; Kim MS; Woo JH; Lee DH; Chung EJ; Park MW; Kim DH; Joo YH
[Ad] Address:Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
[Ti] Title:Clinicopathological factors influencing the outcomes of surgical treatment in patients with T4a hypopharyngeal cancer.
[So] Source:BMC Cancer;17(1):904, 2017 12 29.
[Is] ISSN:1471-2407
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: The purpose of this study was to determine prognostic factors influencing outcomes of surgical treatment in patients with T4a hypopharyngeal cancer. METHODS: The present study enrolled 93 patients diagnosed with T4a hypopharyngeal cancer who underwent primary surgery between January 2005 and December 2015 at six medical centers in Korea. Primary tumor sites included pyriform sinus in 71 patients, posterior pharyngeal wall in 14 patients, and postcricoid region in 8 patients. Seventy-two patients received postoperative radio(chemo)therapy. RESULTS: Five-year disease-free survival (DFS) and disease-specific survival (DSS) rates were 38% and 45%, respectively. In univariate analysis, 5-year DFS was found to have significant and positive correlations with margin involvement (p < 0.001) and extracapsular spread (p = 0.025). Multivariate analysis confirmed that margin involvement (hazard ratio (HR): 2.81; 95% confidence interval (CI): 1.49-5.30; p = 0.001) and extracapsular spread (HR: 2.08; 95% CI: 1.08-3.99; p = 0.028) were significant factors associated with 5-year DFS. In univariate analysis, cervical lymph node metastasis (p = 0.048), lymphovascular invasion (p = 0.041), extracapsular spread (p = 0.015), and esophageal invasion (p = 0.033) were significant factors associated with 5-year DSS. In multivariate analysis, extracapsular spread (HR: 2.98; 95% CI: 1.39-6.42; p = 0.005) and esophageal invasion (HR: 2.87; 95% CI: 1.38-5.98; p = 0.005) remained significant factors associated with 5-year DSS. CONCLUSION: Margin involvement and extracapsular spread are factors influencing recurrence while extracapsular spread and esophageal invasion are factors affecting survival in patients with T4a hypopharyngeal cancer treated by primary surgery.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1712
[Cu] Class update date: 180104
[Lr] Last revision date:180104
[St] Status:In-Process
[do] DOI:10.1186/s12885-017-3880-6

  10 / 3647 MEDLINE  
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[PMID]: 29277812
[Au] Autor:Eguchi K; Suzuki M; Ida S; Mori K; Imai H; Kudo S; Ando K; Higuchi K; Ebara T
[Ad] Address:Division of Head and Neck Surgery, Gunma Prefectural Cancer Center, Gunma, Japan kohtaro.eguchi@gmail.com.
[Ti] Title:Association Between Laryngopharyngeal Reflux and Radiation-induced Mucositis in Head and Neck Cancer.
[So] Source:Anticancer Res;38(1):477-480, 2018 01.
[Is] ISSN:1791-7530
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:BACKGROUND/AIM: We investigated whether laryngopharyngeal reflux (LPR) is a risk factor for radiation-induced mucositis. PATIENTS AND METHODS: This was a retrospective cohort study using our departmental database. The study included patients with stage I or II laryngeal and hypopharyngeal cancers treated with radiation therapy alone between April 2009 and March 2014. Based on endoscopic findings, baseline laryngeal signs were evaluated using the reflux finding score (RFS), and the severity of mucositis was assessed during and after radiation therapy. RESULTS: Fifty-eight patients were enrolled. Thirty-one patients were categorized as high RFS (LPR-likely), while 27 patients were categorized as low RFS (LPR-unlikely). Grade 3 mucositis occurred more frequently in the high RFS group (p<0.042). Furthermore, grade 3 mucositis developed earlier in the high RFS group (p<0.001). CONCLUSION: High RFS (i.e., increased likelihood of LPR) appears to be a potential risk factor for developing severe radiation-induced mucositis.
[Mh] MeSH terms primary: Head and Neck Neoplasms/radiotherapy
Intestinal Mucosa/radiation effects
Laryngopharyngeal Reflux/pathology
Mouth Mucosa/radiation effects
Mucositis/pathology
Radiation Injuries/pathology
[Mh] MeSH terms secundary: Adult
Aged
Aged, 80 and over
Female
Humans
Intestinal Mucosa/pathology
Male
Middle Aged
Mouth Mucosa/pathology
Retrospective Studies
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180104
[Lr] Last revision date:180104
[Js] Journal subset:IM
[Da] Date of entry for processing:171227
[St] Status:MEDLINE


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BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information