Database : MEDLINE
Search on : Iris and Neoplasms [Words]
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[PMID]: 29258990
[Au] Autor:Dyer O
[Ad] Address:Montreal.
[Ti] Title:Police in Xinjiang province gather biometric data under guise of health programme.
[So] Source:BMJ;359:j5865, 2017 12 19.
[Is] ISSN:1756-1833
[Cp] Country of publication:England
[La] Language:eng
[Mh] MeSH terms primary: Biometric Identification/methods
Blood Grouping and Crossmatching/methods
National Health Programs/ethics
Population Surveillance/methods
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Blood Grouping and Crossmatching/statistics & numerical data
Child
China/epidemiology
DNA/genetics
DNA/standards
Humans
Iris
Middle Aged
Young Adult
[Pt] Publication type:NEWS
[Nm] Name of substance:9007-49-2 (DNA)
[Em] Entry month:1802
[Cu] Class update date: 180223
[Lr] Last revision date:180223
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:171221
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j5865

  2 / 2284 MEDLINE  
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[PMID]: 29318350
[Au] Autor:Kupczyk PA; Kukuk GM
[Ad] Address:FE MRT, Radiologische Universitätsklinik Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Deutschland.
[Ti] Title:Benigne mesenchymale Tumoren des Abdomens. [Benign mesenchymal tumors of the abdomen].
[So] Source:Radiologe;58(1):25-35, 2018 Jan.
[Is] ISSN:1432-2102
[Cp] Country of publication:Germany
[La] Language:ger
[Ab] Abstract:BACKGROUND: Benign mesenchymal tumors of the abdomen are-except for hemangiomas-rare neoplasms that are associated with potentially life-threatening complications. Thus, awareness of the most important entities and knowledge of their imaging characteristics is fundamental for the radiologist. OBJECTIVES: An overview of the most frequent benign abdominal soft tissue tumors and their common imaging features is given. Furthermore, other facts concerning the individual entities that are relevant to radiologic practice are outlined. MATERIALS AND METHODS: A literature search and evaluation of the institutional image database were performed. RESULTS: Hemangiomas, desmoid tumors, lipomas and lipoma variants are presented. Typical characteristics and radiological signs (e. g., iris diaphragm sign, band sign, India ink artifact) are elucidated and illustrated by image examples. CONCLUSION: Despite the lack of distinctive imaging features, there are a few radiological characteristics suggestive for each of the entities that in many cases allow for correct diagnosis. In cases of doubt, biopsy or surgery is necessary to distinguish them from malignancies.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1801
[Cu] Class update date: 180121
[Lr] Last revision date:180121
[St] Status:In-Data-Review
[do] DOI:10.1007/s00117-017-0338-4

  3 / 2284 MEDLINE  
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[PMID]: 28453367
[Au] Autor:Abdolrahimzadeh S; Parisi F; Mantelli F; Perdicchi A; Scuderi G
[Ad] Address:a Ophthalmology Unit, DAI Testa/Collo, Azienda Ospedaliera Universitaria Policlinico Umberto I, University of Rome "Sapienza" , Rome , Italy.
[Ti] Title:Retinal pigment epithelium-photoreceptor layer alterations in a patient with Sturge-Weber syndrome with diffuse choroidal hemangioma.
[So] Source:Ophthalmic Genet;38(6):567-569, 2017 Dec.
[Is] ISSN:1744-5094
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:PURPOSE: To describe an 8-year-old girl with diagnosis of Sturge-Weber syndrome (SWS) presenting with glaucoma, abnormal iris vessels, diffuse choroidal hemangioma, and small white dot-shaped "microdrusen-like" alterations of the retina in the right eye. PATIENT AND METHODS: Complete ophthalmological examination was performed with slit-lamp anterior segment assessment and fundus ophthalmoscopy. Near infrared reflectance (NIR) and enhanced depth imaging (EDI) spectral domain optical coherence tomography (SD-OCT) were carried out. RESULTS: Microdrusen-like retinal alterations observed with fundus ophthalmoscopy appeared as multiple hyperreflective dots surrounded by a hyporeflective ring on NIR. EDI SD-OCT showed increased choroidal thickness exceeding 1000 µm. B-scan cross-sectional examination on the hyperreflective dots revealed focal alterations of the retinal pigment epithelial (RPE)-photoreceptor layer. CONCLUSIONS: The increase of the choroidal thickness due to the diffuse choroidal hemangioma caused alterations of the RPE-photoreceptor layer similar to reticular pseudodrusen or pachychoroid pigment epitheliopathy.
[Mh] MeSH terms primary: Choroid Neoplasms/complications
Hemangioma/complications
Photoreceptor Cells, Vertebrate/pathology
Retinal Diseases/etiology
Retinal Pigment Epithelium/pathology
Sturge-Weber Syndrome/complications
[Mh] MeSH terms secundary: Child
Choroid Neoplasms/pathology
Cross-Sectional Studies
Female
Hemangioma/pathology
Humans
Ophthalmoscopy
Retinal Diseases/diagnosis
Slit Lamp
Sturge-Weber Syndrome/diagnosis
Tomography, Optical Coherence
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171201
[Lr] Last revision date:171201
[Js] Journal subset:IM
[Da] Date of entry for processing:170429
[St] Status:MEDLINE
[do] DOI:10.1080/13816810.2017.1313995

  4 / 2284 MEDLINE  
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[PMID]: 28224806
[Au] Autor:Griscíková L; Autrata R; Pramuková K; Mlcák P; Maresová K
[Ti] Title:Melanom duhovky u detského pacienta. [Iris melanoma in a child].
[So] Source:Cesk Slov Oftalmol;72(5):191-194, 2016.
[Is] ISSN:1211-9059
[Cp] Country of publication:Czech Republic
[La] Language:cze
[Ab] Abstract:Iris melanomas are very rare in children. The paper presents the case of a 12-year-old boy with iris melanoma of spindle-cell type A and pre-operatively associated with uncontrolled secondary glaucoma. Tumour resection was complicated by lens extraction and consecutive PC IOL implantation. Antiglaucomatous surgery was performed due to the persistently elevated intraocular pressure. Currently, the intraocular pressure is within the normal range and the patient has no signs of the presence of tumour cells or metastases.Key words: iris melanoma, spindle-cell type, secondary glaucoma.
[Mh] MeSH terms primary: Iris Neoplasms/pathology
Melanoma/pathology
[Mh] MeSH terms secundary: Child
Glaucoma/surgery
Humans
Intraocular Pressure/physiology
Iris Neoplasms/surgery
Lens Implantation, Intraocular
Lens, Crystalline/surgery
Male
Melanoma/surgery
Retrospective Studies
Tonometry, Ocular
Visual Acuity/physiology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171128
[Lr] Last revision date:171128
[Js] Journal subset:IM
[Da] Date of entry for processing:170223
[St] Status:MEDLINE

  5 / 2284 MEDLINE  
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[PMID]: 28993861
[Au] Autor:Westerwick D; Driever F; Le Guin CHD; Schmid KW; Metz KA
[Ad] Address:Institut für Pathologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstraße 55, 45147, Essen, Deutschland.
[Ti] Title:Intraokulare Metastasen. [Intraocular metastases].
[So] Source:Pathologe;38(6):500-506, 2017 Nov.
[Is] ISSN:1432-1963
[Cp] Country of publication:Germany
[La] Language:ger
[Ab] Abstract:Metastatic cancer represents the most common form of intraocular malignancy. Due to its abundant vascular supply the choroid is the most common ocular site for intraocular metastatic disease (approximately 90%). Less than 10% of intraocular metastases are located in the iris and/or ciliary body, whereas the retina and vitreous are rarely affected. Most intraocular metastases are carcinomas; the majority of metastases originate from breast cancer in females and lung cancer in males. However, virtually every primary malignancy has been described to metastasize to intraocular structures. In this review we address the pathology and clinical features of intraocular metastases, noninvasive and invasive diagnostic procedures, as well as the pathological work-up of cytological and histological specimens obtained either by fine needle aspiration biopsy or special biopsy forceps.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1710
[Cu] Class update date: 171031
[Lr] Last revision date:171031
[St] Status:In-Process
[do] DOI:10.1007/s00292-017-0373-y

  6 / 2284 MEDLINE  
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[PMID]: 28942285
[Au] Autor:Liu H; Yue Q; He S
[Ad] Address:Department of Gynaecology, Luoyang Central Hospital, Zhengzhou University, China.
[Ti] Title:Amentoflavone suppresses tumor growth in ovarian cancer by modulating Skp2.
[So] Source:Life Sci;189:96-105, 2017 Nov 15.
[Is] ISSN:1879-0631
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:AIM: Ovarian cancer is one of most common malignancies in women and is associated with high reoccurrence rate and poor prognosis. This study is designed to investigate the anti-tumor effects of amentoflavone (AF), one of the major active ingredients of S. tamariscina, against ovarian cancer. MATERIALS AND METHODS: Human ovarian cancer cell lines SKOV3 and OVCAR-3 were used in this study. The effect of AF on cell viability was examined by CCK-8 assay. Cell apoptosis and cell cycle distribution was determined by flow cytometry. ROS generation was detected using fluorescent staining. Expression of signaling molecules was determined by western blots. Xenograft model was established to evaluate the therapeutic efficacy of AF in vivo. KEY FINDINGS: Our results showed that AF could significantly suppress cell proliferation, induce apoptosis and block cell cycle progression. Mechanistically, downregulation of S-phase kinase protein 2 (Skp2) by AF contributed to its anti-tumor effect against ovarian cancer. Furthermore, our results showed that AF repressed the expression of Skp2 through ROS/AMPK/mTOR signaling. The anti-tumor effect of AF against ovarian cancer was also confirmed in a xenograft animal model. SIGNIFICANCE: Overall, our present findings highlighted the potential of AF in the treatment of ovarian cancer. Moreover, our study also provided a new elucidation regarding the anti-tumor mechanisms of AF.
[Mh] MeSH terms primary: Antineoplastic Agents, Phytogenic/pharmacology
Biflavonoids/pharmacology
Ovarian Neoplasms/drug therapy
S-Phase Kinase-Associated Proteins/genetics
[Mh] MeSH terms secundary: Animals
Antineoplastic Agents, Phytogenic/isolation & purification
Apoptosis/drug effects
Biflavonoids/isolation & purification
Cell Line, Tumor
Cell Proliferation/drug effects
Cell Survival/drug effects
Down-Regulation/drug effects
Female
Humans
Male
Mice
Mice, Inbred BALB C
Mice, Nude
Ovarian Neoplasms/genetics
Ovarian Neoplasms/pathology
Selaginellaceae/chemistry
Xenograft Model Antitumor Assays
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antineoplastic Agents, Phytogenic); 0 (Biflavonoids); 0 (S-Phase Kinase-Associated Proteins); 9I1VC79L77 (amentoflavone)
[Em] Entry month:1710
[Cu] Class update date: 171023
[Lr] Last revision date:171023
[Js] Journal subset:IM
[Da] Date of entry for processing:170925
[St] Status:MEDLINE

  7 / 2284 MEDLINE  
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[PMID]: 28910426
[Au] Autor:Chien JL; Sioufi K; Ferenczy S; Say EAT; Shields CL
[Ad] Address:Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
[Ti] Title:Optical Coherence Tomography Angiography Features of Iris Racemose Hemangioma in 4 Cases.
[So] Source:JAMA Ophthalmol;135(10):1106-1110, 2017 Oct 01.
[Is] ISSN:2168-6173
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Importance: Optical coherence tomography angiography (OCTA) allows visualization of iris racemose hemangioma course and its relation to the normal iris microvasculature. Objective: To describe OCTA features of iris racemose hemangioma. Design, Setting, and Participants: Descriptive, noncomparative case series at a tertiary referral center (Ocular Oncology Service of Wills Eye Hospital). Patients diagnosed with unilateral iris racemose hemangioma were included in the study. Main Outcomes and Measures: Features of iris racemose hemangioma on OCTA. Results: Four eyes of 4 patients with unilateral iris racemose hemangioma were included in the study. Mean patient age was 50 years, all patients were white, and Snellen visual acuity was 20/20 in each case. All eyes had sectoral iris racemose hemangioma without associated iris or ciliary body solid tumor on clinical examination and ultrasound biomicroscopy. By anterior segment OCT, the racemose hemangioma was partially visualized in all cases. By OCTA, the hemangioma was clearly visualized as a uniform large-caliber vascular tortuous loop with intense flow characteristics superimposed over small-caliber radial iris vessels against a background of low-signal iris stroma. The vascular course on OCTA resembled a light bulb filament (filament sign), arising from the peripheral iris (base of light bulb) and forming a tortuous loop on reaching its peak (midfilament) near the pupil (n = 3) or midzonal iris (n = 1), before returning to the peripheral iris (base of light bulb). Intravenous fluorescein angiography performed in 1 eye depicted the iris hemangioma; however, small-caliber radial iris vessels were more distinct on OCTA than intravenous fluorescein angiography. Conclusions and Relevance: Optical coherence tomography angiography is a noninvasive vascular imaging modality that clearly depicts the looping course of iris racemose hemangioma. Optical coherence tomography angiography depicted fine details of radial iris vessels, not distinct on intravenous fluorescein angiography.
[Mh] MeSH terms primary: Hemangioma/diagnosis
Iris Neoplasms/diagnosis
[Mh] MeSH terms secundary: Adult
Aged
Ciliary Arteries/pathology
Computed Tomography Angiography
Female
Hemangioma/physiopathology
Humans
Iris/blood supply
Iris Neoplasms/physiopathology
Male
Microscopy, Acoustic
Middle Aged
Retrospective Studies
Tomography, Optical Coherence/methods
Visual Acuity/physiology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Entry month:1710
[Cu] Class update date: 171023
[Lr] Last revision date:171023
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:170915
[St] Status:MEDLINE
[do] DOI:10.1001/jamaophthalmol.2017.3390

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[PMID]: 28715582
[Au] Autor:Schwab C; Mayer C; Zalaudek I; Riedl R; Richtig M; Wackernagel W; Hofmann-Wellenhof R; Richtig G; Langmann G; Tarmann L; Wedrich A; Richtig E
[Ad] Address:Department of Ophthalmology, Medical University of Graz, Graz, Austria.
[Ti] Title:Iris Freckles a Potential Biomarker for Chronic Sun Damage.
[So] Source:Invest Ophthalmol Vis Sci;58(6):BIO174-BIO179, 2017 May 01.
[Is] ISSN:1552-5783
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Purpose: To investigate the role of sunlight exposure in iris freckles formation. Methods: We prospectively examined volunteers attending a skin cancer screening program conducted by ophthalmologists and dermatologists. Frequency and topographical variability of iris freckles were noted and associated with behavioral and dermatologic characteristics indicating high sun exposure. Results: Six hundred thirty-two participants (n = 360; 57% female) were examined. Mean age of all participants was 38.4 ± 18.4 years (range, 4-84 years). Of all individuals, 76.1% (n = 481) exhibited at least one iris freckle. Most freckles were observed in the inferior temporal quadrant. The presence of iris freckles was associated with higher age (participants with iris freckles: 41.8 ± 16.8 years versus participants without iris freckles: 27.6 ± 19.2 years), a high number of sunburns during lifetime (>10: 31% vs. 19%), sunlight-damaged skin (26% vs. 11%), presence of actinic lentigines (72% vs. 45%), and a high total nevus body count (>10; 78% vs. 67%). Conclusions: The association of iris freckles, behavioral factors, and dermatologic findings, as well as the topographical distribution, indicate that sunlight exposure may trigger the formation of iris freckles. The evaluation of iris freckles offers an easily accessible potential biomarker, which might be helpful in indicating sun damage on the skin associated with cutaneous malignancies. Furthermore, the evaluation of iris freckles could also be helpful in understanding the role of sunlight in several ophthalmologic diseases.
[Mh] MeSH terms primary: Biomarkers
Iris Diseases/etiology
Iris/radiation effects
Melanosis/etiology
Radiation Injuries/etiology
Sunlight/adverse effects
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Aged, 80 and over
Aging/physiology
Child
Child, Preschool
Chronic Disease
Eye Color
Female
Humans
Iris Diseases/diagnosis
Male
Melanosis/diagnosis
Middle Aged
Nevus, Pigmented/diagnosis
Nevus, Pigmented/etiology
Prospective Studies
Radiation Injuries/diagnosis
Skin/radiation effects
Skin Neoplasms/diagnosis
Skin Neoplasms/etiology
Sunburn/complications
Surveys and Questionnaires
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Biomarkers)
[Em] Entry month:1707
[Cu] Class update date: 170728
[Lr] Last revision date:170728
[Js] Journal subset:IM
[Da] Date of entry for processing:170718
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21751

  9 / 2284 MEDLINE  
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[PMID]: 28700778
[Au] Autor:Scholz SL; Möller I; Reis H; Süßkind D; van de Nes JAP; Leonardelli S; Schilling B; Livingstone E; Schimming T; Paschen A; Sucker A; Murali R; Steuhl KP; Schadendorf D; Westekemper H; Griewank KG
[Ad] Address:Department of Ophthalmology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium (DKTK), Essen, Germany.
[Ti] Title:Frequent GNAQ, GNA11, and EIF1AX Mutations in Iris Melanoma.
[So] Source:Invest Ophthalmol Vis Sci;58(9):3464-3470, 2017 Jul 01.
[Is] ISSN:1552-5783
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Purpose: The most common malignant intraocular tumors with a high mortality in adults are uveal melanomas. Uveal melanomas arise most frequently in the choroid or ciliary body (97%) and rarely in the iris (3%). Whereas conjunctival and posterior uveal (ciliary body and choroidal) melanomas have been studied in more detail genetically, little data exist regarding iris melanomas. Methods: In our study, we genetically analyzed 19 iris melanomas, 8 ciliary body melanomas, 3 ring melanomas, and 4 iris nevi. A targeted next-generation sequencing approach was applied, covering the mutational hotspot regions of nine genes known to be mutated in conjunctival and uveal melanoma (BRAF, NRAS, KIT, GNAQ, GNA11, CYSLTR2, SF3B1, EIF1AX, and BAP1). Results: Activating GNAQ or GNA11 hotspot mutations were detected in a mutually exclusive fashion in 84% (16/19) of iris melanomas. EIF1AX gene mutations also were frequent, detected in 42% (8/19) of iris melanomas. In 4 iris nevi, one GNAQ mutation was identified. GNAQ, GNA11, EIF1AX, and BAP1 mutations were identified at varying frequencies in ciliary body and ring melanomas. Conclusions: In this most comprehensive genetic analysis of iris melanomas published to date, we find iris melanomas to be related genetically to choroidal and ciliary body melanomas, frequently harboring GNAQ, GNA11, and EIF1AX mutations. Future studies will need to assess if screening mutation profiles in iris melanomas may be of diagnostic or prognostic value.
[Mh] MeSH terms primary: DNA, Neoplasm/genetics
Eukaryotic Initiation Factor-1/genetics
GTP-Binding Protein alpha Subunits, Gq-G11/genetics
GTP-Binding Protein alpha Subunits/genetics
Iris Neoplasms/genetics
Melanoma/genetics
Mutation
[Mh] MeSH terms secundary: Aged
DNA Mutational Analysis
Eukaryotic Initiation Factor-1/metabolism
Female
GTP-Binding Protein alpha Subunits/metabolism
GTP-Binding Protein alpha Subunits, Gq-G11/metabolism
Humans
Iris Neoplasms/metabolism
Iris Neoplasms/pathology
Male
Melanoma/metabolism
Melanoma/pathology
Middle Aged
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (DNA, Neoplasm); 0 (Eukaryotic Initiation Factor-1); 0 (GNA11 protein, human); 0 (GNAQ protein, human); 0 (GTP-Binding Protein alpha Subunits); 0 (eukaryotic peptide initiation factor-1A); EC 3.6.5.1 (GTP-Binding Protein alpha Subunits, Gq-G11)
[Em] Entry month:1708
[Cu] Class update date: 170809
[Lr] Last revision date:170809
[Js] Journal subset:IM
[Da] Date of entry for processing:170713
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21838

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[PMID]: 28673748
[Au] Autor:Fabian ID; Thaung C; AlHarby L; Sisley K; Mudhar HS; Doherty RE; Stacey AW; Arora AK; Cohen VML; Sagoo MS
[Ad] Address:Ocular Oncology Service, Moorfields Eye Hospital, London, United Kingdom; Ocular Oncology Service, Goldschleger Eye Institute, Sheba Medical Center, Tel-Aviv University, Tel Aviv, Israel. Electronic address: didifabian@gmail.com.
[Ti] Title:Late Solitary Extraocular Recurrence From Previously Resected Iris Melanoma.
[So] Source:Am J Ophthalmol;181:97-105, 2017 Sep.
[Is] ISSN:1879-1891
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To report on cases of late extraocular relapse of previously resected iris melanoma, without concurrent intraocular recurrence. DESIGN: Retrospective case series. METHODS: A retrospective chart review of 4 patients diagnosed with late subconjunctival relapse of previously resected iris melanoma. RESULTS: Three female patients and 1 male patient underwent iris tumor resection and presented to our service with suspicious conjunctival lesions at a median of 22 years later (mean: 21 years). None showed intraocular relapse. Treatment of the conjunctival tumors included excisional biopsy (n = 4), followed by cryotherapy (n = 3) and/or brachytherapy (n = 3). In all cases, histopathology confirmed malignant melanoma, with no intraepithelial component or associated melanosis. Genetic sequencing (n = 3) showed wild-type BRAF and NRAS in all. GNA11 mutation was found in 1 case. On array-based comparative genomic hybridization (n = 3), gain of 6p was found in 2 cases and gain of 8 in 2. Overall, findings were strongly suggestive of a diagnosis of late extraocular relapse from previously resected iris melanoma. In a median of 2.5 years (mean: 7.7 years) from the subconjunctival relapse, no further episodes of intraocular/extraocular recurrence were recorded, and all patients were free from distant metastasis. CONCLUSIONS: Patients undergoing iris melanoma resection are at risk of developing late solitary extraocular relapse even more than 30 years after surgery. In the absence of an intraocular component, diagnosis may be challenging, as tumors mimic a primary conjunctival lesion. Management by excisional biopsy followed by adjuvant therapy was successful, and histopathology and genetic analysis supported a diagnosis of extraocular uveal tumor spread rather than a primary conjunctival tumor.
[Mh] MeSH terms primary: Conjunctival Neoplasms/pathology
Iris Neoplasms/surgery
Melanoma/pathology
Melanoma/surgery
Ophthalmologic Surgical Procedures
[Mh] MeSH terms secundary: Adult
Aged, 80 and over
Brachytherapy
Comparative Genomic Hybridization
Conjunctival Neoplasms/genetics
Conjunctival Neoplasms/therapy
Cryotherapy
Female
GTP Phosphohydrolases/genetics
GTP-Binding Protein alpha Subunits/genetics
Humans
Iris Neoplasms/pathology
Male
Melanoma/genetics
Melanoma/therapy
Membrane Proteins/genetics
Middle Aged
Neoplasm Invasiveness
Proto-Oncogene Proteins B-raf/genetics
Retrospective Studies
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (GNA11 protein, human); 0 (GTP-Binding Protein alpha Subunits); 0 (Membrane Proteins); EC 2.7.11.1 (BRAF protein, human); EC 2.7.11.1 (Proto-Oncogene Proteins B-raf); EC 3.6.1.- (GTP Phosphohydrolases); EC 3.6.1.- (NRAS protein, human)
[Em] Entry month:1709
[Cu] Class update date: 170911
[Lr] Last revision date:170911
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:170705
[St] Status:MEDLINE


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