Database : MEDLINE
Search on : Jaw and Cysts [Words]
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[PMID]: 29524025
[Au] Autor:Meschi N; Fieuws S; Vanhoenacker A; Strijbos O; Van der Veken D; Politis C; Lambrechts P
[Ad] Address:Department of Oral Health Sciences, Endodontology, KU Leuven & Dentistry, University Hospitals Leuven, Kapucijnenvoer 7 blok a- box 7001, 3000 Leuven, Belgium. nastaran.meschi@kuleuven.be.
[Ti] Title:Root-end surgery with leucocyte- and platelet-rich fibrin and an occlusive membrane: a randomized controlled clinical trial on patients' quality of life.
[So] Source:Clin Oral Investig;, 2018 Mar 09.
[Is] ISSN:1436-3771
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:OBJECTIVES: The aim of this study was to investigate the impact of the adjunct of leukocyte- and platelet-rich fibrin (LPRF) to root-end surgery (RES) on the patients' quality of life during the first week post RES. MATERIALS AND METHODS: Patients in need of RES were recruited for an open randomized controlled clinical trial (RCT) with a 2 × 2 factorial design. They were randomly allocated to the test (+LPRF) and control (-LPRF) group. Each group was subsequently divided into two strata: with or without an occlusive membrane (Bio-Gide®, Geistlich Biomaterials, Switzerland; BG). After RES, the patients completed daily for 1 week a visual analog pain scale (VAS) and a 5-point Likert-type scale questionnaire concerning activity impairment, occurrence of symptoms, and medication use. RESULTS: Fifty patients were included, equally divided between the test and control group. Only one patient in the "-LPRF+BG-group" had to take additional antibiotics due to a persistent jaw swelling. There was no evidence (p ≤ 0.05) for a difference between the test and control group in VAS, occurrence of pain symptoms, impairment of daily activities, and medication use, over the 7 days and daily during the 7 days post RES. CONCLUSIONS: There was no statistical significant evidence for improvement of patients' quality of life during the first week post RES with LPRF in comparison with RES without LPRF. CLINICAL RELEVANCE: Although LPRF seems to be an inexpensive and autologous agent to reduce pain and swelling post RES, this RCT does not provide a statistical significant evidence for that.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1007/s00784-018-2343-z

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[PMID]: 29510866
[Au] Autor:Brito LNS; de Lemos Almeida MMR; de Souza LB; Alves PM; Nonaka CFW; Godoy GP
[Ad] Address:State University of Paraíba, Campina Grande, Paraíba, Brazil; Federal University of Pernambuco, Recife, Pernambuco, Brazil.
[Ti] Title:Immunohistochemical Analysis of Galectins-1, -3, and -7 in Periapical Granulomas, Radicular Cysts, and Residual Radicular Cysts.
[So] Source:J Endod;, 2018 Mar 03.
[Is] ISSN:1878-3554
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Galectins play important roles in immunoinflammatory responses, but their participation in the development of periapical lesions remains unclear. This study aimed to evaluate the expressions of galectins-1, -3, and -7 in periapical lesions, correlating them with the intensity of the inflammatory infiltrate and the pattern of the cystic epithelium. METHODS: Twenty periapical granulomas (PGs), 20 radicular cysts (RCs), and 20 residual radicular cysts (RRCs) were submitted to immunohistochemistry using anti-galectin-1, -3, and -7 antibodies. The percentage of immunopositive cells in epithelial and connective tissues was determined. RESULTS: In connective tissue, PGs exhibited higher cytoplasmic/membrane expression of galectins-1 and -7 than RCs and RRCs (P < .05). There was higher nuclear expression of galectin-1 in PGs compared with RCs and RRCs (P < .05). The expression of galectins-1 and -7 in connective tissue was higher in lesions with grade III inflammation (P < .05). No significant differences in galectin-3 immunoexpression were observed for any of the parameters evaluated (P > .05). In the epithelial component, a higher nuclear expression of galectin-7 was detected in RRCs (P < .05), and a higher cytoplasmic/membrane expression of this protein was found in cysts with hyperplastic epithelium (P < .05). Positive correlations were observed between the nuclear and cytoplasmic/membrane expression of galectin-1 in connective tissue (P < .05) as well as between the nuclear and cytoplasmic/membrane expression of galectin-7 in epithelial tissue of cysts (P < .05). CONCLUSIONS: Galectins-1 and -7 may play important roles in the pathogenesis of PGs, RCs, and RRCs. On the other hand, the present results suggest only a minor involvement of galectin-3 in the development of these lesions.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:Publisher

  3 / 2865 MEDLINE  
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[PMID]: 29287708
[Au] Autor:Wolkow N; Jakobiec FA; Yoon MK
[Ad] Address:David Cogan Ophthalmic Pathology Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.
[Ti] Title:Intratarsal keratinous eyelid cysts in Gorlin syndrome: A review and reappraisal.
[So] Source:Surv Ophthalmol;, 2017 Dec 27.
[Is] ISSN:1879-3304
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:A 38-year-old woman presented with multiple bilateral recurrent eyelid cysts. Her medical history was notable for Gorlin (nevoid basal cell carcinoma) syndrome. Histopathologic and immunohistochemical examinations revealed that the lesions were intratarsal keratinous cysts. They were similar in appearance to sporadic intratarsal keratinous cysts and closely resembled odontogenic keratocysts of the jaw. Eyelid cysts occur in up to 40% of patients with Gorlin syndrome; however, their description has been cursory and, for the most part, outside of the ophthalmic literature. Although ophthalmologists are familiar with the periocular basal cell carcinomas that occur in patients with Gorlin syndrome, up to 10% of patients never develop a basal cell carcinoma, but they may manifest other ophthalmic findings. Awareness of these other features may contribute to the earlier diagnosis of the syndrome. We discuss the clinical and histopathologic features of intratarsal keratinous cysts in Gorlin syndrome, comparing them to sporadic intratarsal keratinous cysts, other eyelid cysts, and jaw cysts that also characterize this syndrome. We briefly review the ocular and systemic manifestations of Gorlin syndrome and recent genetic and therapeutic developments so that the eyelid cysts may be appreciated within the appropriate context of Gorlin syndrome as a whole.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1712
[Cu] Class update date: 180211
[Lr] Last revision date:180211
[St] Status:Publisher

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[PMID]: 29414392
[Au] Autor:Kechik KA; Siar CH
[Ad] Address:Dental Specialist Clinic, Hospital Raja Permaisuri Bainun, Jalan Raja Ashman, 30450 Ipoh, Perak, Malaysia. Electronic address: dr.khamisah@moh.gov.my.
[Ti] Title:Spatial distribution of osteopontin, CD44v6 and podoplanin in the lining epithelium of odontogenic keratocyst, and their biological relevance.
[So] Source:Ann Diagn Pathol;32:17-22, 2018 Feb.
[Is] ISSN:1532-8198
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND AND AIMS: The odontogenic keratocyst (OKC) remains the most challenging jaw cyst to treat because of its locally-aggressive behaviour and high recurrence potential. Emerging evidence suggests that osteopontin, its receptors CD44v6 and integrin α , and podoplanin, have a role in the local invasiveness of this cyst. However the spatial distribution characteristics of these pro-invasive markers in the lining epithelium of OKC, and their association with the clinicopathologic parameters of OKC are largely unexplored. This study sought to address these issues in comparison with dentigerous cysts (DCs) and radicular cysts (RCs) and to evaluate their biological relevance. METHODS: A sample consisting of 20 OKC cases, 10 DCs and 10 RCs was subjected to immunohistochemical staining for osteopontin, CD44v6 and integrin α , and podoplanin, and semiquantitative analysis was performed. RESULTS: All factors (except integrin α ) were detected heterogeneously in the constitutive layers of the lining epithelium in all three cyst types. Key observations were significant upregulation of CD44v6 and podoplanin in OKC compared to DCs and RCs, suggesting that these protein molecules may play crucial roles in promoting local invasiveness in OKC (P<0.05). Osteopontin underexpression and distribution patterns were indistinctive among all three cysts indicating its limited role as pro-invasive factor. Clinical parameters showed no significant correlations with all protein factors investigated. CONCLUSIONS: Present findings suggest that an osteopontin CD44v6 and podoplanin immunoprofile most probably represent epithelial signatures of OKC and are markers of local invasiveness in this cyst.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180207
[Lr] Last revision date:180207
[St] Status:In-Process

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[PMID]: 29233700
[Au] Autor:Kauke M; Safi AF; Grandoch A; Nickenig HJ; Zöller J; Kreppel M
[Ad] Address:Department for Oral and Craniomaxillofacial Plastic Surgery, University of Cologne, Cologne, Germany.
[Ti] Title:Volumetric analysis of keratocystic odontogenic tumors and non-neoplastic jaw cysts - Comparison and its clinical relevance.
[So] Source:J Craniomaxillofac Surg;46(2):257-263, 2018 Feb.
[Is] ISSN:1878-4119
[Cp] Country of publication:Scotland
[La] Language:eng
[Ab] Abstract:The keratocystic odontogenic tumor (KCOT) is capable of causing vast osseous destruction. Histopathological examination is pivotal for diagnosis. The diagnostic process can sometimes be hindered by tissue inflammation of KCOTs with loss of defining criteria, resulting in misdiagnosis as an odontogenic jaw cyst. We discuss the possible merits of volumetric analysis when facing this particular diagnostic dilemma and for pathophysiological characterization of KCOTs. We included 114 patients, of whom 27 were histopathologically diagnosed with a KCOT and 87 with dentigerous (n = 41) and periapical cyst (n = 46). Semiautomatic segmentation and radiological analysis of preoperative cone beam computed tomography (CBCT) image data was carried out using ITK-SNAP. The mean volumetric extent of KCOTs is significantly higher compared to non-neoplastic odontogenic jaw cysts (p = 0.001). The mean volume and standard deviation for KCOTs and non-neoplastic odontogenic jaw cysts was 10381 mm ± 6410 and 5813 mm ± 4425, respectively. Volumetric analysis reveals that KCOTs significantly exceed the mean size of non-neoplastic odontogenic jaw cysts, adding an argument in favor of the neoplastic nature of KCOTs. In the case of difficult histopathological examination, lesions with a size exceeding a value of about 3000 mm could be considered for close clinico-radiologic follow-up.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180207
[Lr] Last revision date:180207
[St] Status:In-Process

  6 / 2865 MEDLINE  
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[PMID]: 29396318
[Au] Autor:Buchbender M; Neukam FW; Lutz R; Schmitt CM
[Ad] Address:Department of Oral and Maxillofacial Surgery, University of Erlangen-Nuremberg, Erlangen, Germany. Electronic address: Mayte.buchbender@uk-erlangen.de.
[Ti] Title:Treatment of enucleated odontogenic jaw cysts: a systematic review.
[So] Source:Oral Surg Oral Med Oral Pathol Oral Radiol;, 2017 Dec 29.
[Is] ISSN:2212-4411
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVES: In this systematic review, we aimed to assess the impact of filling or not filling enucleated odontogenic jaw cysts on bony defect consolidation. In terms of filling, we aimed to assess which is the best filling material based on current evidence. STUDY DESIGN: An electronic search was performed using PubMed, Embase, and MEDLINE databases with the logical operators: "odontogenic cysts" AND "jaw cysts" AND "treatment AND therapy." RESULTS: Thirteen studies with primary enucleation (6 with filling and 7 without filling) were included. In terms of filling, either synthetic bone substitutes or autologous bone were used. The primary outcome was bony regeneration judged by radiographic follow-up measurements. Two-dimensional (2-D) radiographic follow-up measurements (densitometry) revealed a bone density increase and comparable bone regeneration in both groups. CONCLUSIONS: Because of the low number of studies and the heterogeneity of the included data, evidence-based treatment recommendations cannot be given at this time. Also, outcomes based on 2-D measurements should be interpreted with caution. However, the following factors are suggested as having an impact on bony defect consolidation: defect size, defect configuration, the preservation of the periosteum, and localization (upper or lower jaw). Prospective comparable clinical studies with a 3-dimensional follow-up are needed.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180203
[Lr] Last revision date:180203
[St] Status:Publisher

  7 / 2865 MEDLINE  
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[PMID]: 29336428
[Au] Autor:Manohar B; Baidya D; Bhuvaneswari S; Rai AB
[Ad] Address:Department of Periodontics, Pacific Dental College and Hospital, Debari. Udaipur, Rajasthan, Pin. - 313024.
[Ti] Title:Keratocystic Odontogenic Tumour Mimicking Lateral Periodontal Cyst: A Diagnostic Dilemma.
[So] Source:Kathmandu Univ Med J (KUMJ);14(56):370-372, 2016 Oct.-Dec..
[Is] ISSN:1812-2078
[Cp] Country of publication:Nepal
[La] Language:eng
[Ab] Abstract:The Keratocystic Odontogenic Tumor is a developmental cyst derived from the enamel organ or from the dental lamina. It is a benign, multicystic, intraosseous tumor of odontogenic origin, with a characteristic lining of parakeratinized stratified squamous epithelium and has a potential for aggressive, infiltrative behavior and recurrence. Keratocystic Odontogenic Tumors have a predilection for males and occurs mainly in the second and third decade of life, most commonly in the mandible, mostly in the posterior body, the angle and the ascending ramus. It extends in the intramedullary space making it difficult to diagnose at an early stage. It is regarded as a distinctive entity because of its characteristic histology, proliferation kinetics and behavior. Main in 1970 described, collateral variant of Keratocystic Odontogenic Tumor, which presents adjacent to the roots of the teeth usually in the mandibular premolar region and radiologically is indistinguishable from the lateral periodontal cyst and gingival cyst.
[Mh] MeSH terms primary: Jaw Abnormalities/diagnosis
Jaw Abnormalities/pathology
Odontogenic Cysts/diagnosis
Odontogenic Cysts/pathology
[Mh] MeSH terms secundary: Aged
Diagnosis, Differential
Humans
Male
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180129
[Lr] Last revision date:180129
[Js] Journal subset:IM
[Da] Date of entry for processing:180117
[St] Status:MEDLINE

  8 / 2865 MEDLINE  
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[PMID]: 29187222
[Au] Autor:Hadzisejdic I; Babarovic E; Vranic L; Duletic Nacinovic A; Lucin K; Krasevic M; Jonjic N
[Ad] Address:Department of Pathology, Faculty of Medicine, University of Rijeka, Brace Branchetta 20, 51000, Rijeka, Croatia. ita.hadzisejdic@medri.uniri.hr.
[Ti] Title:Unusual presentation of plasmablastic lymphoma involving ovarian mature cystic teratoma: a case report.
[So] Source:Diagn Pathol;12(1):83, 2017 Nov 29.
[Is] ISSN:1746-1596
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Plasmablastic lymphoma (PBL) is relatively new clinical entity described as a distinct subtype of diffuse large B-cell lymphoma (DLBCL). It is characterized by its aggressive nature and proliferation of large neoplastic cells resembling immunoblasts including cells with more obvious plasmacytic differentiation. In this case report, we describe an unexpected finding of PBL associated with a mature cystic teratoma of the ovary in a young immune competent woman. CASE PRESENTATION: A 19-year old woman was admitted to the hospital with generalized lymphadenopathy, a pelvic tumor mass measuring 35 × 30 cm and a 4 cm lump in her right breast. She underwent a right salpingo-oophorectomy, lymphadenectomy, splenectomy, omentectomy, and a right breast lumpectomy. On macroscopic examination the right ovary was replaced by a thick-walled multilocular cystic tumor. Upon incision, the cysts were filled with thick, greasy sebaceous material and hair and there were several solid nodules within the cyst walls. Histological examination revealed a mature cystic teratoma and malignant non-Hodgkin lymphoma (NHL) within the solid nodules. Tumor tissue from the right breast, spleen and lymph nodes, all had the same histological, NHL morphology. After extensive immunostaining, a diagnosis of PBL was made. Following surgery, the patient was treated with different chemotherapy regimens, without any significant regression of the disease, and died of multiple organ failure. CONCLUSIONS: Primary NHL of the ovary is relatively rare occurrence while secondary involvement by lymphoma is much more common. PBL is a rare lymphoma, primarily reported in the jaw and oral mucosa, but also documented in extra-oral sites. To the best of our knowledge, this is the first case described in a mature ovarian cystic teratoma. Although the patient was HIV-negative and immune competent, she had progressive disease and died despite aggressive chemotherapy 11 months after the initial diagnosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171219
[Lr] Last revision date:171219
[St] Status:In-Process
[do] DOI:10.1186/s13000-017-0672-x

  9 / 2865 MEDLINE  
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[PMID]: 29243681
[Au] Autor:Gendviliene I; Legrand P; Nicolielo LFP; Sinha D; Spaey Y; Politis C; Jacobs R
[Ad] Address:Institute of Odontology, Faculty of Medicine, Vilnius University, Zalgiris str. 115, LT-08217, Vilnius, Lithuania. ieva.gendviliene@gmail.com.
[Ti] Title:Conservative management of large mandibular dentigerous cysts with a novel approach for follow up: Two case reports.
[So] Source:Stomatologija;19(1):24-32, 2017.
[Is] ISSN:1822-301X
[Cp] Country of publication:Lithuania
[La] Language:eng
[Ab] Abstract:BACKGROUND: Dentigerous cysts are odontogenic cysts of the jaws accounting for approximately 24% of all epithelium-lined jaw cysts. Rarely, these cysts can become extremely large causing additional symptoms, while challenging treatment. This article represents a novel approach for radiological treatment follow up of large dentigerous cysts. MATERIAL AND METHODS: Dentigerous cysts were treated by marsupialization, using dedicated obturators and enucleation of the cyst afterwards. Teeth vitality in the lesion was regularly assessed by laser doppler flowmetry, follow-up of lesion regression was accomplished using semi-automatic radiographic analysis of bone healing quantification. RESULTS: Cystic marsupialization by means of the obturator resulted in a number of advantages compared to a conventional approach: lower risk of spontaneous fracture of the mandible, anatomical structure preservation, mandibular canal identification and preservation of tooth vitality as measured by intraoral laser doppler flowmetry. Notwithstanding that a 1-year follow-up panoramic image could not visualize a remnant bone defect nor cystic lesion recurrence, 3D-CBCT based semi-automated bone quantification could only demonstrate an increase of 46% of mineralized bone volume one year after surgery. Bone healing typically occurred starting from the periphery of the original lesion towards the inner core. CONCLUSIONS: The presently reported cystic marsupialization was useful as a preliminary treatment for subsequent enucleation. 3-D CBCT based objective quantification of the bone volume and healing can provide new insights in lesion healing in general and more particular in the outcome of specific diagnostic and therapeutic challenges.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171215
[Lr] Last revision date:171215
[St] Status:In-Process

  10 / 2865 MEDLINE  
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[PMID]: 29157551
[Au] Autor:Ahmad M; Gaalaas L
[Ad] Address:Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA. Electronic address: ahmad005@umn.edu.
[Ti] Title:Fibro-Osseous and Other Lesions of Bone in the Jaws.
[So] Source:Radiol Clin North Am;56(1):91-104, 2018 Jan.
[Is] ISSN:1557-8275
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Fibroosseous lesions in the jaws have similar histologic and radiographic features. Despite their similarity, management varies significantly. In this article, common fibroosseous lesions and key radiographic features are described. Many of the fibroosseous lesions are diagnosed radiographically, without performing histologic examinations. For some of the fibroosseous lesions, for example, periapical osseous dysplasia, histologic examination is contraindicated. Cherubism and fibrous dysplasia have specific radiographic findings; these conditions can be diagnosed radiographically. Accurate diagnosis conditions is essential; some conditions do not require any intervention, while others require surgical resection. Patient demographics, for example, age, gender, and race, play important roles in diagnosis.
[Mh] MeSH terms primary: Fibroma, Ossifying/diagnosis
Jaw Cysts/diagnosis
Jaw Diseases/diagnosis
Medical History Taking/methods
Periapical Diseases/diagnosis
Physical Examination/methods
Radiography, Dental/methods
[Mh] MeSH terms secundary: Diagnosis, Differential
Humans
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1711
[Cu] Class update date: 171128
[Lr] Last revision date:171128
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:171122
[St] Status:MEDLINE


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