Database : MEDLINE
Search on : Kaposi and Varicelliform and Eruption [Words]
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[PMID]: 29446473
[Au] Autor:Okamoto M; Takahagi S; Tanaka A; Ogawa A; Nobuki H; Hide M
[Ad] Address:Department of Dermatology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
[Ti] Title:A case of Kaposi varicelliform eruption progressing to herpes simplex virus hepatitis in an immunocompetent patient.
[So] Source:Clin Exp Dermatol;, 2018 Feb 15.
[Is] ISSN:1365-2230
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180215
[Lr] Last revision date:180215
[St] Status:Publisher
[do] DOI:10.1111/ced.13405

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[PMID]: 28468973
[Au] Autor:Tian T; Jin MQ; Dubin K; King SL; Hoetzenecker W; Murphy GF; Chen CA; Kupper TS; Fuhlbrigge RC
[Ad] Address:Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; ttian@partners.org Robert.Fuhlbrigge@childrenscolorado.org.
[Ti] Title:IL-1R Type 1-Deficient Mice Demonstrate an Impaired Host Immune Response against Cutaneous Vaccinia Virus Infection.
[So] Source:J Immunol;198(11):4341-4351, 2017 06 01.
[Is] ISSN:1550-6606
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The IL-1 superfamily of cytokines and receptors has been studied extensively. However, the specific roles of IL-1 elements in host immunity to cutaneous viral infection remain elusive. In this study, we applied vaccinia virus (VACV) by scarification to IL-1R1 knockout mice (IL-1R1 ) and found that these mice developed markedly larger lesions with higher viral genome copies in skin than did wild-type mice. The phenotype of infected IL-1R1 mice was similar to eczema vaccinatum, a severe side effect of VACV vaccination that may develop in humans with atopic dermatitis. Interestingly, the impaired cutaneous response of IL-1R1 mice did not reflect a systemic immune deficiency, because immunized IL-1R1 mice survived subsequent lethal VACV intranasal challenge, or defects of T cell activation or T cell homing to the site of inoculation. Histologic evaluation revealed that VACV infection and replication after scarification were limited to the epidermal layer of wild-type mice, whereas lack of IL-1R1 permitted extension of VACV infection into dermal layers of the skin. We explored the etiology of this discrepancy and determined that IL-1R1 mice contained significantly more macrophages and monocyte-derived dendritic cells in the dermis after VACV scarification. These cells were vulnerable to VACV infection and may augment the transmission of virus to adjacent skin, thus leading to larger skin lesions and satellite lesions in IL-1R1 mice. These results suggest new therapeutic strategies for treatment of eczema vaccinatum and inform assessment of risks in patients receiving IL-1 blocking Abs for treatment of chronic inflammatory disorders.
[Mh] MeSH terms primary: Interleukin 1 Receptor Antagonist Protein/deficiency
Interleukin 1 Receptor Antagonist Protein/immunology
Skin Diseases, Infectious/immunology
Skin/pathology
Vaccinia virus/immunology
Vaccinia/immunology
[Mh] MeSH terms secundary: Administration, Cutaneous
Animals
CD8-Positive T-Lymphocytes/immunology
Interleukin 1 Receptor Antagonist Protein/genetics
Kaposi Varicelliform Eruption/immunology
Kaposi Varicelliform Eruption/physiopathology
Kaposi Varicelliform Eruption/therapy
Mice
Mice, Inbred C57BL
Mice, Knockout
Skin/anatomy & histology
Skin/immunology
Skin/virology
Vaccination
Vaccinia virus/physiology
Virus Replication
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Interleukin 1 Receptor Antagonist Protein)
[Em] Entry month:1709
[Cu] Class update date: 180131
[Lr] Last revision date:180131
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:170505
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1500106

  3 / 398 MEDLINE  
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[PMID]: 28927889
[Au] Autor:Hsu DY; Shinkai K; Silverberg JI
[Ad] Address:Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA.
[Ti] Title:Epidemiology of eczema herpeticum in hospitalized US children: Analysis of a nationwide cohort.
[So] Source:J Invest Dermatol;, 2017 Sep 16.
[Is] ISSN:1523-1747
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Eczema herpeticum (EH) is characterized by viral infection of a preexisting inflammatory dermatosis and is associated with considerable morbidity. In this cross-sectional study, we sought to determine the incidence, risk factors, comorbidities, costs of care, length of stay, and mortality in hospitalized US children with EH. The Nationwide Inpatient Sample 2002-2012, containing a 20% sample of all US hospitalizations, was analyzed. We used a validated approach involving ICD-9-CM codes to identify patients primarily admitted for EH (n=4655 weighted). The mean annual incidence of hospitalization for EH per million children ranged from 4.03-7.30, increasing significantly in 2008 to 2012. EH was associated with younger age (odds ratio [95% confidence interval] for 3-4 years: 1.29 [1.02-1.64]), non-white race/ethnicity (black: 2.93 [2.35-3.66]; Asian: 4.41 [3.34-5.83]; Native American: 2.96 [1.51-5.78]), but less likely to occur in areas with lower income quartiles (quartile-1: 0.66 [0.53-0.84]; quartile-2: 0.68 [0.54-0.87]; quartile-3: 0.70 [0.56-0.88]). EH was associated with atopic dermatitis (11.72 [9.48-14.49]). Increased LOS and costs of care were associated with Asian race. Mean length of stay (LOS) was 3.86±0.09 days and cost of care was $5,237.6±160.6. Overall mortality was 0.1%. EH in hospitalized children pose a substantial burden to the health care system.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170920
[Lr] Last revision date:170920
[St] Status:Publisher

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[PMID]: 28813215
[Au] Autor:Micali G; Lacarrubba F
[Ad] Address:University of Catania, Catania, Italy cldermct@gmail.com.
[Ti] Title:Eczema Herpeticum.
[So] Source:N Engl J Med;377(7):e9, 2017 Aug 17.
[Is] ISSN:1533-4406
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Dermatitis, Atopic/complications
Herpesvirus 1, Human/isolation & purification
Kaposi Varicelliform Eruption/pathology
[Mh] MeSH terms secundary: Child
Female
Humans
Kaposi Varicelliform Eruption/etiology
Kaposi Varicelliform Eruption/virology
Leg/pathology
Superinfection
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170830
[Lr] Last revision date:170830
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:170817
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMicm1701668

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[PMID]: 28584772
[Au] Autor:Naveen KN; Bhandary DJ; Chandan MD; Athaniker SB
[Ad] Address:Department of Dermatology, SDM College of Medical Sciences and Hospital, Sattur, Dharwad, Karnataka, India.
[Ti] Title:Kaposi's Varicelliform Eruption in Phenytoin-Induced Erythroderma.
[So] Source:Indian Dermatol Online J;8(3):231-232, 2017 May-Jun.
[Is] ISSN:2229-5178
[Cp] Country of publication:India
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1706
[Cu] Class update date: 170816
[Lr] Last revision date:170816
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/idoj.IDOJ_220_16

  6 / 398 MEDLINE  
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[PMID]: 28514819
[Au] Autor:Kalampalikis A; Antonov D; Tittelbach J; Elsner P
[Ti] Title:39-jährige Frau mit eruptiven Hautveränderungen im Gesicht. [39-year-old Woman with Eruptive Skin Lesions on the Face].
[So] Source:Dtsch Med Wochenschr;142(10):721-722, 2017 May.
[Is] ISSN:1439-4413
[Cp] Country of publication:Germany
[La] Language:ger
[Mh] MeSH terms primary: Breast/pathology
Face/pathology
Kaposi Varicelliform Eruption
Psoriasis
Skin/pathology
[Mh] MeSH terms secundary: Adult
Exanthema/pathology
Female
Humans
Kaposi Varicelliform Eruption/diagnosis
Kaposi Varicelliform Eruption/pathology
Psoriasis/diagnosis
Psoriasis/pathology
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170911
[Lr] Last revision date:170911
[Js] Journal subset:IM
[Da] Date of entry for processing:170518
[St] Status:MEDLINE
[do] DOI:10.1055/s-0043-101211

  7 / 398 MEDLINE  
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[PMID]: 28385896
[Au] Autor:Kim EL; Hohmuth B
[Ad] Address:Department of Internal Medicine (Kim), Englewood Hospital and Medical Center, Englewood, NJ; Department of Hospital Medicine (Hohmuth), Geisinger Medical Center, Danville, Penn. maylilith@gmail.com.
[Ti] Title:Eczema herpeticum in early pregnancy.
[So] Source:CMAJ;189(13):E505, 2017 04 03.
[Is] ISSN:1488-2329
[Cp] Country of publication:Canada
[La] Language:eng
[Mh] MeSH terms primary: Kaposi Varicelliform Eruption/diagnosis
Pregnancy Complications, Infectious/diagnosis
[Mh] MeSH terms secundary: Acyclovir/therapeutic use
Adult
Antiviral Agents/therapeutic use
Dermatitis, Atopic
Female
Humans
Kaposi Varicelliform Eruption/drug therapy
Pregnancy
Pregnancy Complications, Infectious/drug therapy
Pregnancy Trimester, First
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Antiviral Agents); X4HES1O11F (Acyclovir)
[Em] Entry month:1710
[Cu] Class update date: 171016
[Lr] Last revision date:171016
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:170408
[St] Status:MEDLINE
[do] DOI:10.1503/cmaj.151544

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[PMID]: 28242091
[Au] Autor:Seta V; Fichel F; Méritet JF; Bouam S; Franck N; Avril MF; Dupin N
[Ad] Address:Service de dermatologie, hôpital Cochin, université Paris Descartes, Assistance publique-Hôpitaux de Paris (AP-HP), pavillon Tarnier, 89, rue d'Assas, 75006 Paris, France.
[Ti] Title:Dermatoses et surinfection herpétique : étude rétrospective de 34 cas. [Dermatoses and herpes superinfection: A retrospective study of 34 cases].
[So] Source:Ann Dermatol Venereol;144(3):176-181, 2017 Mar.
[Is] ISSN:0151-9638
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:BACKGROUND: Although varicelliform Kaposi eruption is a well-known complication of dermatoses, it has not been widely investigated. AIM: To investigate features of dermatoses and herpes superinfection in patients hospitalized in a dermatology department. PATIENTS AND METHODS: We performed a single-centre, retrospective study between 2008 and 2014 that included cases of Kaposi varicelliform eruptions defined by positive PCR of an unconventional site of herpetic recurrence in a setting of active dermatitis. A record was compiled of each case giving details of the history, clinical and laboratory findings, therapeutic data and outcome. RESULTS: Thirty-four cases of Kaposi varicelliform eruptions in 30 subjects were studied. Mean age at diagnosis was 63.3±24.2 years. The underlying dermatoses were as follows: 7 pemphigus, 6 bullous pemphigoid, 3 cicatricial pemphigoid, 3 atopic dermatitis, 1 Darier disease, and 14 other dermatoses. Patients presented with skin (94.1 %) or mucous membrane lesions (62 %), mostly erosive (79 %), vesicular (27 %) or bullous (41 %), often painful (56 %) or pruritic (29 %). At diagnosis, 41.2 % were undergoing systemic immunotherapy and 24 % were on topical corticosteroids. PCR was positive for HSV1 in 20 cases and for HSV2 in 4 cases, and indeterminate in 10 cases. Lymphocytopenia was seen in 59 % of cases. The majority of patients received treatment. Nine patients experienced at least one relapse. CONCLUSION: Our study confirms the over-representation not only of the expected dermatoses (pemphigus and atopic dermatitis), but also of others such as pemphigoid and acute dermatoses; these results should be investigated in a more systematic prospective study.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1703
[Cu] Class update date: 170313
[Lr] Last revision date:170313
[St] Status:In-Process

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[PMID]: 27882598
[Au] Autor:Fujii M; Takahashi I; Honma M; Ishida-Yamamoto A
[Ad] Address:Department of Dermatology, Kitami Red Cross Hospital, Kitami, Japan.
[Ti] Title:Kaposi's varicelliform eruption presenting with extensive skin lesions and sepsis.
[So] Source:J Dermatol;44(10):1180-1181, 2017 Oct.
[Is] ISSN:1346-8138
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1611
[Cu] Class update date: 171004
[Lr] Last revision date:171004
[St] Status:In-Data-Review
[do] DOI:10.1111/1346-8138.13674

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[PMID]: 27476888
[Au] Autor:Kawakami Y; Ando T; Lee JR; Kim G; Kawakami Y; Nakasaki T; Nakasaki M; Matsumoto K; Choi YS; Kawakami T
[Ad] Address:Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, Calif.
[Ti] Title:Defective natural killer cell activity in a mouse model of eczema herpeticum.
[So] Source:J Allergy Clin Immunol;139(3):997-1006.e10, 2017 Mar.
[Is] ISSN:1097-6825
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Patients with atopic dermatitis (AD) are susceptible to several viruses, including herpes simplex virus (HSV). Some patients experience 1 or more episodes of a severe skin infection caused by HSV termed eczema herpeticum (EH). There are numerous mouse models of AD, but no established model exists for EH. OBJECTIVE: We sought to establish and characterize a mouse model of EH. METHODS: We infected AD-like skin lesions with HSV1 to induce severe skin lesions in a dermatitis-prone mouse strain of NC/Nga. Gene expression was investigated by using a microarray and quantitative PCR; antibody titers were measured by means of ELISA; and natural killer (NK) cell, cytotoxic T-cell, regulatory T-cell, and follicular helper T-cell populations were evaluated by using flow cytometry. The role of NK cells in HSV1-induced development of severe skin lesions was examined by means of depletion and adoptive transfer. RESULTS: Inoculation of HSV1 induced severe erosive skin lesions in eczematous mice, which had an impaired skin barrier, but milder lesions in small numbers of normal mice. Eczematous mice exhibited lower NK cell activity but similar cytotoxic T-cell activity and humoral immune responses compared with normal mice. The role of NK cells in controlling HSV1-induced skin lesions was demonstrated by experiments depleting or transferring NK cells. CONCLUSION: A murine model of EH with an impaired skin barrier was established in this study. We demonstrated a critical role of defective NK activities in the development of HSV1-induced severe skin lesions in eczematous mice.
[Mh] MeSH terms primary: Kaposi Varicelliform Eruption/immunology
Killer Cells, Natural/immunology
Simplexvirus
[Mh] MeSH terms secundary: Animals
Cytokines/genetics
Disease Models, Animal
Female
Gene Expression
Immunoglobulin G/immunology
Kaposi Varicelliform Eruption/genetics
Kaposi Varicelliform Eruption/pathology
Male
Mice
Simplexvirus/immunology
Skin/metabolism
Skin/pathology
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Cytokines); 0 (Immunoglobulin G)
[Em] Entry month:1707
[Cu] Class update date: 170721
[Lr] Last revision date:170721
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:160802
[St] Status:MEDLINE


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